ID   Q54496_STRNO            Unreviewed;       409 AA.
AC   Q54496;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   19-JAN-2010, entry version 43.
DE   SubName: Full=Snoa2;
GN   Name=snoa2;
OS   Streptomyces nogalater.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=38314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 27451;
RX   MEDLINE=96242142; PubMed=8668120; DOI=10.1007/s004380050147;
RA   Ylihonko K., Tuikkanen J., Jussila S., Cong L., Mantsala P.;
RT   "A gene cluster involved in nogalamycin biosynthesis from Streptomyces
RT   nogalater: sequence analysis and complementation of early-block
RT   mutations in the anthracycline pathway.";
RL   Mol. Gen. Genet. 251:113-120(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 27451;
RX   MEDLINE=98007868; PubMed=9349712; DOI=10.1007/s004380050562;
RA   Torkkell S., Ylihonko K., Hakala J., Skurnik M., Mantsala P.;
RT   "Characterization of Streptomyces nogalater genes encoding enzymes
RT   involved in glycosylation steps in nogalamycin biosynthesis.";
RL   Mol. Gen. Genet. 256:203-209(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 27451;
RX   MEDLINE=96349102; PubMed=8760909;
RA   Ylihonko K., Hakala J., Kunnari T., Mantsala P.;
RT   "Production of hybrid anthracycline antibiotics by heterologous
RT   expression of Streptomyces nogalater nogalamycin biosynthesis genes.";
RL   Microbiology 142:1965-1972(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 27451;
RA   Palmu K., Hautala A., Kunnari T., Hakala J., Mantsala P., Ylihonko K.;
RT   "Identification and fuctional analysis of a glycosyltransferase gene
RT   (snogZ) and a resistance gene (snorO) from the nogalamycin producer,
RT   Streptomyces nogalater.";
RL   Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 27451;
RA   Ylihonko K.P.J.;
RL   Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the beta-ketoacyl-ACP synthases family.
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DR   EMBL; AJ224512; CAA12018.1; -; Genomic_DNA.
DR   PIR; S69229; S69229.
DR   HSSP; P73283; 1E5M.
DR   SMR; Q54496; 4-401.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   Gene3D; G3DSA:3.40.47.10; Thiolase-like_subgr; 2.
DR   PANTHER; PTHR11712; Ketoacyl_synth; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
PE   3: Inferred from homology;
KW   Transferase.
SQ   SEQUENCE   409 AA;  42583 MW;  93A8784508E15717 CRC64;
     MTAAVVVTGL GVVAPTGLGV REHWSSTVRG ASAIGPVTRF DAGRYPSKLA GEVPGFVPED
     HLPSRLMPQT DHMTRLALVA ADWAFQDAAV DPSKLPEYGV GVVTASSAGG FEFGHRELQN
     LWSLGPQYVS AYQSFAWFYA VNTGQVSIRH GLRGPGGVLV TEQAGGLDAL GQARRQLRRG
     LPMVVAGAVD GSPCPWGWVA QLSSGGLSTS DDPRRAYLPF DAAAGGHVPG EGGALLVLES
     DESARARGVT RWYGRIDGYA ATFDPPPGSG RPPNLLRAAQ AALDDAEVGP EAVDVVFADA
     SGTPDEDAAE ADAVRRLFGP YGVPVTAPKT MTGRLSAGGA ALDVATALLA LREGVVPPTV
     NVSRPRPEYE LDLVLAPRRT PLARALVLAR GRGGFNAAMV VAGPRAETR
//