ID Q6MZ72_MYCUA Unreviewed; 14130 AA.
AC Q6MZ72;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 19-JAN-2010, entry version 44.
DE SubName: Full=Type I modular polyketide synthase;
GN Name=mlsB; OrderedLocusNames=MUP032c;
OS Mycobacterium ulcerans (strain Agy99).
OG Plasmid pMUM001.
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX NCBI_TaxID=362242;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14736915; DOI=10.1073/pnas.0305877101;
RA Stinear T.P., Mve-Obiang A., Small P.L.C., Frigui W., Pryor M.J.,
RA Brosch R., Jenkin G.A., Johnson P.D.R., Davies J.K., Lee R.E.,
RA Adusumilli S., Garnier T., Haydock S.F., Leadlay P.F., Cole S.T.;
RT "Giant plasmid-encoded polyketide synthases produce the macrolide
RT toxin of Mycobacterium ulcerans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:1345-1349(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15758215; DOI=10.1099/mic.0.27674-0;
RA Stinear T.P., Pryor M.J., Porter J.L., Cole S.T.;
RT "Functional analysis and annotation of the virulence plasmid pMUM001
RT from Mycobacterium ulcerans.";
RL Microbiology 151:683-692(2005).
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DR EMBL; BX649209; CAE46843.1; -; Genomic_DNA.
DR RefSeq; YP_025554.1; -.
DR GeneID; 2846550; -.
DR GenomeReviews; BX649209_GR; MUP032c.
DR KEGG; mul:MUP032c; -.
DR BuruList; MUP032c; -.
DR GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR InterPro; IPR001227; Ac_transferase_dom.
DR InterPro; IPR009081; Acyl_carrier_prot-like.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPlipase.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR006163; Phsphopanteth_bd.
DR InterPro; IPR020842; PKS/FAS_KR.
DR InterPro; IPR020801; PKS_acyl_transferase.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_reg.
DR InterPro; IPR020807; PKS_dehydratase.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR006162; PPantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR016038; Thiolase-like_subgr.
DR Gene3D; G3DSA:3.40.366.10; Ac_transferase_reg; 8.
DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 8.
DR Gene3D; G3DSA:3.40.47.10; Thiolase-like_subgr; 16.
DR PANTHER; PTHR11712; Ketoacyl_synth; 1.
DR Pfam; PF00698; Acyl_transf_1; 8.
DR Pfam; PF00109; ketoacyl-synt; 8.
DR Pfam; PF02801; Ketoacyl-synt_C; 8.
DR Pfam; PF08659; KR; 8.
DR Pfam; PF00550; PP-binding; 8.
DR SMART; SM00827; PKS_AT; 8.
DR SMART; SM00826; PKS_DH; 6.
DR SMART; SM00822; PKS_KR; 8.
DR SMART; SM00825; PKS_KS; 8.
DR SMART; SM00823; PKS_PP; 8.
DR PROSITE; PS50075; ACP_DOMAIN; 8.
DR PROSITE; PS00606; B_KETOACYL_SYNTHASE; 7.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 8.
PE 4: Predicted;
KW Complete proteome; Phosphopantetheine; Plasmid; Transferase.
SQ SEQUENCE 14130 AA; 1497639 MW; A150D995F1815034 CRC64;
MIFGDAHQNC RGGRVLGDAV AVVGMSCRVP GASDPDALWA LLRDGISVVD EIPSARWNLD
GLVAHRLTDE QRSALRHGAF LDDVEGFDAA FFGINPSEAG SMDPQQRLML ELTWAALEDA
RIVPEHLSGS SSGVFTGAMS DDYTTAVTYR AAMTAHTFAG THRSLIANRV SYTLGLRGPS
LVIDTGQSSS LVAVHVAMES LRREETSLAI AGGIHLNLSL AAALSAAHFG ALSPDGRCYT
FDARANGYVR GEGGGVVVLK RLNDALADGN HIYCVIRGSS VNNDGATQDL TAPGVDGQRQ
ALLQAYERAE IDPSEVQYVE LHGTGTRLGD PTEAHSLHSV FGTSTVPRSP LLVGSIKTNI
GHLEGAAGIL GLIKTALAVH HRQLPPSLNY TVPNPKIPLE QLGLRVQTTL SEWPDLDKPL
TAGVSSFSMG GTNAHLILQQ PPTPDTTQTP NPTTGSDPAV GSDPAVGVLV WPLSARSAPG
LSAQAARLYQ HLSAHPDLDP IDVAHSLATT RSHHPHRATI TTSIEHHSEN NHDTTDALAA
LHALANNGTH PLLSRGLLTP QGPGKTVFVF PGQGSQYPGM GADLYRQFPV FAHALDEVAA
ALNPHLDVAL LEVMFSQQDT AMAQLLDQTF YAQPALFALG TALHRLFTHA GIHPDYLLGH
SIGELTAAYA AGVLSLQDAA TLVTSRGRLM QSCTPGGTML ALQASEAEVQ PLLEGLDHAV
SIAAINGATS IVLSGDHDSL EQIGEHFITQ DRRTTRLQVS HAFHSPHMDP ILEQFRQIAA
QLTFSAPTLP ILSNLTGQIA RHDQLASPDY WTQQLRNTVR FHDTVAALLG AGEQVFLELS
PHPVLTQAIT DTVEQAGGGG AAVPALRKDR PDAVAFAAAL GQLHCHGISP SWNVLYCQAR
PLTLPTYAFQ HQRYWLLPTA GDFSGANTHA MHPLLDTATE LAENRGWVFT GRISPRTQPW
LNEHAVESAV LFPNTGFVEL ALHVADRAGY SSVNELIVHT PLLLAGHDTA DLQITVTDTD
DMGRQSLNIH SHPHIGHDNT TTGDEQPEWV LHASAVLTAQ TTDHNHLPLT PVPWPPPGTA
AIEVDDFYDD LAAQGYNYGP TFQGVQRIWR DHATPDVIYA EVELPEDTDI DGYGIHPALF
DAALHPLLAL TQPPTNDTDD TNTADTGDQV RLPYAFTGIS LHATHATRLR VRLTRTGADA
ITVHTSDTTG APVAIIDSLI TRPLTTATGS APATTAAGLL HLSWPPHPDT TTDTDTDTDA
LRYQVIAEPT QQLPRYLHDL HTSTDLHTST TEADVVVWPV PVPSNEELQA HQASDTAVSS
RIHTLTRQTL TVVQDWLTHP DTTGTRLVIV TRHGVSTSAH DPVPDLAHAA VWGLIRSAQN
EHPGRFTLLD TDDNTNSDTL TTALTLPTRE NQLAIRRDTI HIPRLTRHSS DGALTAPVVV
DPEGTVLITG GTGTLGALFA EHLVSAHGVR HLLLTSRRGP QAHGATDLQQ RLTDLGAHVT
ITACDISDPE ALAALVNSVP TQHRLTAVVH TAAVLADTPV TELTGDQLDQ VLAPKIDAAW
QLHQLTYEHN LSAFIMFSSM AGMIGSPGQG NYAAANTALD ALADYRHRLG LPATSLAWGY
WQTHTGLTAH LTDVDLARMT RLGLMPIATS HGLALFDAAL ATGQPVSIPA PINTHTLARH
ARDNTLAPIL SALITTPRRR AASAATDLAA RLNGLSPQQQ QQTLATLVAA ATATVLGHHT
PESISPATAF KDLGIDSLTA LELRNTLTHN TGLNLSSTLI FDHPTPHAVA EHLLEQIPGI
GALVPAPVVI AAGRTEEPVA VVGMACRFPG GVASADQLWD LVIAGRDVVG NFPADRGWDV
EGLFDPDPDA VGKTYTRYGA FLDDAAGFDA GFFGISPREA RAMDPQQRLL LEVCWEALET
AGIPAHTLAG TSTGVFVGAW AQSYGATNSD DAEGYAMTGG ATSVMSGRIA YTLGLEGPAI
TVDTACSSSL VAIHLACQSL RNNESQLALA GGVTVMSTPA VFTEFSRQRG LAPDGRCKAF
AATADGTGWG EGAAVLVLER LSEARRNNHP VLAIVAGSAI NQDGASNGLT APHGPSQQRV
INQALANAGL THDQVDAVEA HGTGTTLGDP IEASALHATY GHHHTPDQPL WLGSIKSNIG
HTQAAAGAAG VVKMIQAITH ATLPATLHVD QPSPHIDWSS GTVRLLTEPI QWPNTDHPRT
AAVSSFGISG TNAHLILQQP PTPNPTQTPE DCSPAQSPCA TITDAGTGLS FVPWVISAKS
AEALSAQASR LLTRLDDDPV VDAIDLGWSL IATRSMFEHR AVVVGADRHQ LQRGLAELAS
GNLGADVVVG RARAAGETVM VFPGQGSQRL GMGAQLYEQF PVFAAAFDDV VDALDQYLRL
PLRQVMWGDD EGLLNSTEFA QPSLFAVEVA LFALLRFWGV VPDYVIGHSV GELAAAQVAG
VLSLQDAAKL VSARGRLMQA LPAGGAMVAV AASQHEVEPL LVEGVDIAAL NAPGSVVISG
DQAAVRLIAN RLADRGYRAH ELAVSHAFHS SLMEPMLEEF ARLASEIVVE QPQIPLISNV
TGQLANADYG SAGYWVDHIR RPVRFADSVA SLEAMGASCF IEVGPASGLG AAIEQSLKSA
EPTVSVSALS TDKPESVAVL RAAARLSTSG IPVDWQSVFD GRSTQTVNLP TYAFQRQRFW
LDANRIGQGD PASQPQAQNV ESRFWEAVER EDVDGLADSI GVTASAMQTV LPALSSWRRA
ERTQSELDSW RYQVTWLSSP ATPSSITLSG IWLLIVPSEL AKTDPVIGCA AALEAHGALV
TIITIFEPDF NRSLMGASLK DIGSHISGVI SFLGIHGSEF SDSGAVKTLN LVQAMGDVHL
DVPLWCLTQG AVSISADDLI RCSSAALVWG LGRVVALEHP GSWGGLVDLP ESPDDAAWER
LCALLAQPTD EDQFAIRPSG VFLRRLIHAP ATTTSKSSTA WAPRGTVLIT GGTGALGAHV
ARWLAHKYES VDLLLTSRRG MAADGATELV DDLRTAGASV TVHACDVTDR TSVEAAIAGK
SLDAVFHLAG RHQPTLLTEL EDESFSDELA PKVHGAQVLS DITSNLTLSA FVMFSSVAGI
WGGKSQGAYA AANAFLDSLA EKRRTLGLPA TSVAWGLWAG GGMGDRPSAS GLNLIGLKSM
SADLAVQALS DAIDRPQATL TVASVNWDRF YPTFALARPR PFLHEITEVM AYRESMRSSS
ASTATLLTSK LAGLTATEQR AVTRKLVLDQ AASVLGYAST ESLDTHESFK DLGFDSLTAL
ELRDHLQTAT GLNLSSTLIF DHPTPHAVAE HLLEQIPGIG ALVPAPVVIA AGRTEEPVAV
VGMACRFPGG VASADQLWDL VIAGRDVVGN FPADRGWDVE GLFDPDPDAV GKTYTRYGAF
LDDAAGFDAG FFGISPREAR AMDPQQRLLL EVCWEALETA GIPAHTLAGT STGVFVGAWA
QSYGATNSDD AEGYAMTGGA TSVMSGRIAY TLGLEGPAIT VDTACSSSLV AIHLACQSLR
NNESQLALAG GVTVMSTPAV FTEFSRQRGL APDGRCKAFA ATADGTGWGE GAAVLVLERL
SEARRNNHPV LAIVAGSAIN QDGASNGLTA PHGPSQQRVI NQALANAGLT HDQVDAVEAH
GTGTTLGDPI EASALHATYG HHHTPDQPLW LGSIKSNIGH TQAAAGAAGV VKMIQAITHA
TLPATLHVDQ PSPHIDWSSG TVRLLTEPIQ WPNTDHPRTA AVSSFGISGT NAHLILQQPP
TPNPTQTPED CSPAQSPCAT ITDAGTGLSF VPWVISAKSA EALSAQASRL LTRLDDDPVV
DAIDLGWSLI ATRSMFEHRA VVVGADRHQL QRGLAELASG NLGADVVVGR ARAAGETVMV
FPGQGSQRLG MGAQLYEQFP VFAAAFDDVV DALDQYLRLP LRQVMWGDDE GLLNSTEFAQ
PSLFAVEVAL FALLRFWGVV PDYVIGHSVG ELAAAQVAGV LSLQDAAKLV SARGRLMQAL
PAGGAMVAVA ASQHEVEPLL VEGVDIAALN APGSVVISGD QAAVRLIANR LADRGYRAHE
LAVSHAFHSS LMEPMLEEFA RLASEIVVEQ PQIPLISNVT GQLANADYGS AGYWVDHIRR
PVRFADSVAS LEAMGASCFI EVGPASGLGA AIEQSLKSAE PTVSVSALST DKPESVAVLR
AAARLSTSGI PVDWQSVFDG RSTQTVNLPT YAFQRQRFWL DANRIGQGDP ASQPQAQNVE
SRFWEAVERE DVDGLADSIG VTASAMQTVL PALSSWRRAE RTQSELDSWR YQVTWLSSPA
TPSSITLSGI WLLIVPSELA KTDPVIGCAA ALEAHGALVT IITIFEPDFN RSLMGASLKD
IGSHISGVIS FLGIHGSEFS DSGAVKTLNL VQAMGDVHLD VPLWCLTQGA VSISADDLIR
CSSAALVWGL GRVVALEHPG SWGGLVDLPE SPDDAAWERL CALLAQPTDE DQFAIRPSGV
FLRRLIHAPA TTTSKSSTAW APRGTVLITG GTGALGAHVA RWLAHKYESV DLLLTSRRGM
AADGATELVD DLRTAGASVT VHACDVTDRT SVEAAIAGKS LDAVFHLAGR HQPTLLTELE
DESFSDELAP KVHGAQVLSD ITSNLTLSAF VMFSSVAGIW GGKSQGAYAA ANAFLDSLAE
KRRTLGLPAT SVAWGLWAGG GMGDRPSASG LNLIGLKSMS ADLAVQALSD AIDRPQATLT
VASVNWDRFY PTFALARPRP FLHEITEVMA YRESMRSSSA STATLLTSKL AGLTATEQRA
VTRKLVLDQA ASVLGYASTE SLDTHESFKD LGFDSLTALE LRDHLQTATG LNLSSTLIFD
HPTPHAVAEH LLEQIPGIGA LVPAPVVIAA GRTEEPVAVV GMACRFPGGV ASADQLWDLV
IAGRDVVGNF PADRGWDVEG LFDPDPDAVG KTYTRYGAFL DDAAGFDAGF FGISPREARA
MDPQQRLLLE VCWEALETAG IPAHTLAGTS TGVFVGAWAQ SYGATNSDDA EGYAMTGGAI
SVMSGRIAYT LGLEGPAITV DTACSSSLVA IHLACQSLRN NESQLALTGG VTVMSTPAIF
TEFSRQRGLA PDGRCKAFAA TADGTGWGEG AAVLVLERLS EARRNNHPVL AIVAGSAINQ
DGASNGLTAP HGPSQQRVIN QALANAGLTH DQVDAVEAHG TGTTLGDPIE ASALHATYGH
HHTPDQPLWL GSIKSNIGHT QAAAGAAGVV KMIQAITHAT LPATLHVDQP SPHIDWSSGT
VRLLTEPIQW PNTDHPRTAA VSSFGISGTN AHLILQQPPT PDTTQTPNTT TGSDPAVGSD
PAVGVLVWPL SARSAPGLSA QAARLYQHLS AHPDLDPIDV AHSLATTRSH HPHRATITTS
IEHHSENNHD TTDALAALHA LANNGTHPLL SRGLLTPQGP GKTVFVFPGQ GSQYPGMGAD
LYRQFPVFAH ALDACDAALQ PFTGWSVLAV LHDEPEAPSL ERVDVVQPVL FSVMVSLAAL
WRWAGITPDA VIGHSQGEIA AAHVAGALTL PEAAAVVALR SRVLTDLAGA GAMASVLSPE
EPLTQLLARW DGKITVAAVN GPASAVVSGD TTAITELLIT CEHENIDARA IPVDYPSHSP
YMEHIRHQFL DELPELTPRP STIAMYSTVD GEPHDTAYDT TTMTADYWYR NIRNTVRFHD
TVAALLGAGE QVFLELSPHP VLTQAITDTV EQAGGGGAAV PALRKDRPDA VAFAAALGQL
HCHGISPSWN VLYCQARPLT LPTYAFQHQR YWLLPTAGDF SGANTHAMHP LLDTATELAE
NRGWVFTGRI SPRTQPWLNE HAVESAVLFP GTGFVELALH VADRAGYSSV NELIVHTPLL
LAGHDTADLQ ITVTDTDDMG RQSLNIHSRP HIGHDNTTTG DEQPEWVLHA SAVLTAQTTD
HNHLPLTPVP WPPPGTAAIE VDDFYDDLAA QGYNYGPTFQ GVQRIWRDHA TPDVIYAEVE
LPEDTDIDGY GIHPALFDAA LHPLLALTQP PTNDTDDTNT ADTGDQVRLP YAFTGISLHA
THATRLRVRL TRTGADAITV HTSDTTGAPV AIIDSLITRP LTTATGSAPA TTAAGLLHLS
WPPHPDTTTD TDTDTDALRY QVIAEPTQQL PRYLHDLHTS TDLHTSTTEA DVVVWPVPVP
SNEELQAHQA SDTAVSSRIH TLTRQTLTVV QDWLTHPDTT GTRLVIVTRH GVSTSAHDPV
PDLAHAAVWG LIRSAQNEHP GRFTLLDTDD NTNSDTLTTA LTLPTRENQL AIRRDTIHIP
RLTRHSSDGA LTAPVVVDPE GTVLITGGTG TLGALFAEHL VSAHGVRHLL LTSRRGPQAH
GATDLQQRLT DLGAHVTITA CDISDPEALA ALVNSVPTQH RLTAVVHTAA VLADTPVTEL
TGDQLDQVLA PKIDAAWQLH QLTYEHNLSA FIMFSSMAGM IGSPGQGNYA AANTALDALA
DYRHRLGLPA TSLAWGYWQT HTGLTAHLTD VDLARMTRLG LMPIATSHGL ALFDAALATG
QPVSIPAPIN THTLARHARD NTLAPILSAL ITTPRRRAAS AATDLAARLN GLSPQQQQQT
LATLVAAATA TVLGHHTPES ISPATAFKDL GIDSLTALEL RNTLTHNTGL DLPPTLIFDH
PTPHAVAEHL LEQIPGIGAL VPAPVVIAAG RTEEPVAVVG MACRFPGGVA SADQLWDLVI
AGRDVVGNFP ADRGWDVEGL FDPDPDAVGK TYTRYGAFLD DAAGFDAGFF GISPREARAM
DPQQRLLLEV CWEALETAGI PAHTLAGTST GVFAGAWAQS YGATNSDDAE GYAMTGGSTS
VMSGRIAYTL GLEGPAITVD TACSSSLVAI HLACQSLRNN ESQLALAGGV TVMSTPAVFT
EFSRQRGLAP DGRCKAFAAT ADGTGFGEGA AVLVLERLSE ARRNNHPVLA IVAGSAINQD
GASNGLTAPH GPSQQRVINQ ALANAGLTHD QVDAVEAHGT GTTLGDPIEA SALHATYGHH
HTPDQPLWLG SIKSNIGHTQ AAAGAAGVVK MIQAITHATL PATLHVDQPS PHIDWSSGTV
RLLTEPIQWP NTDHPRTAAV SSFGISGTNA HLILQQPPTP DTTQTPNPTT GSDPAVGSDP
AVGVLVWPLS ARSAPGLSAQ AARLYQHLSA HPDLDPIDVA HSLATTRSHH PHRATITTSI
EHHSENNHDT TDALAALHAL ANNGTHPLLS RGLLTPQGPG KTVFVFPGQG SQYPGMGADL
YRQFPVFAHA LDEVAAALNP HLDVALLEVM FSQQDTAMAQ LLDQTFYAQP ALFALGTALH
RLFTHAGIHP DYLLGHSIGE LTAAYAAGVL SLQDAATLVT SRGRLMQSCT PGGTMLALQA
SEAEVQPLLE GLDHAVSIAA INGATSIVLS GDHDSLEQIG EHFITQDRRT TRLQVSHAFH
SPHMDPILEQ FRQIAAQLTF SAPTLPILSN LTGQIARHDQ LASPDYWTQQ LRNTVRFHDT
VAALLGAGEQ VFLELSPHPV LTQAITDTVE QAGGGGAAVP ALRKDRPDAV AFAAALGQLH
CHGISPSWNV LYCQARPLTL PTYAFQHQRY WLLPTAGDFS GANTHAMHPL LDTATELAEN
RGWVFTGRIS PRTQPWLNEH AVESAVLFPG TGFVELALHV ADRAGYSSVN ELIVHTPLLL
AGHDTADLQI TVTDTDDMGR QSLNIHSRPH IGHDNTTTGD EQPEWVLHAS AVLTAQTTDH
NHLPLTPVPW PPPGTAAIEV DDFYDDLAAQ GYNYGPTFQG VQRIWRDHAT PDVIYAEVEL
PEDTDIDGYG IHPALFDAAL HPLLALTQPP TNDTDDTNTA DTGDQVRLPY AFTGISLHAT
HATRLRVRLT RTGADAITVH TSDTTGAPVA IIDSLITRPL TTATGSAPAT TAAGLLHLSW
PPHPDTTTDT DTDTDALRYQ VIAEPTQQLP RYLHDLHTST DLHTSTTEAD VVVWPVPVPS
NEELQAHQAS DTAVSSRIHT LTRQTLTVVQ DWLTHPDTTG TRLVIVTRHG VSTSAHDPVP
DLAHAAVWGL IRSAQNEHPG RFTLLDTDDN TNSDTLTTAL TLPTRENQLA IRRDTIHIPR
LTRHSSDGAL TAPVVVDPEG TVLITGGTGT LGALFAEHLV SAHGVRHLLL TSRRGPQAHG
ATDLQQRLTD LGAHVTITAC DISDPEALAA LVNSVPTQHR LTAVVHTAAV LADTPVTELT
GDQLDQVLAP KIDAAWQLHQ LTYEHNLSAF IMFSSMAGMI GSPGQGNYAA ANTALDALAD
YRHRLGLPAT SLAWGYWQTH TGLTAHLTDV DLARMTRLGL MPIATSHGLA LFDAALATGQ
PVSIPAPINT HTLARHARDN TLAPILSALI TTPRRRAASA ATDLAARLNG LSPQQQQQTL
ATLVAAATAT VLGHHTPESI SPATAFKDLG IDSLTALELR NTLTHNTGLD LPPTLIFDHP
TPHAVAEHLL EQIPGIGALV PAPVVIAAGR TEEPVAVVGM ACRFPGGVAS ADQLWDLVIA
GRDVVGNFPA DRGWDVEGLF DPDPDAVGKT YTRYGAFLDD AAGFDAGFFG ISPREARAMD
PQQRLLLEVC WEALETAGIP AHTLAGTSTG VFAGAWAQSY GATNSDDAEG YAMTGGATSV
MSGRIAYTLG LEGPAITVDT ACSSSLVAIH LACQSLRNNE SQLALAGGVT VMSTPAVFTE
FSRQRGLAPD GRCKAFAATA DGTGFGEGAA VLVLERLSEA RRNNHPVLAI VAGSAINQDG
ASNGLTAPHG PSQQRVINQA LANAGLTHDQ VDAVEAHGTG TTLGDPIEAS ALHATYGHHH
TPDQPLWLGS IKSNIGHTQA AAGAAGVVKM IQAITHATLP ATLHVDQPSP HIDWSSGTVR
LLTEPIQWPN TDHPRTAAVS SFGISGTNAH LILQQPPTPD TTQTPNTTTG SDPAVGSDPA
VGVLVWPLSA RSAPGLSAQA ARLYQHLSAH PDLDPIDVAH SLATTRSHHP HRATITTSIE
HHSENNHDTT DALAALHALA NNGTHPLLSR GLLTPQGPGK TVFVFPGQGS QYPGMGADLY
RQFPVFAHAL DACDAALQPF TGWSVLAVLH DEPEAPSLER VDVVQPVLFS VMVSLAALWR
WAGITPDAVI GHSQGEIAAA HVAGALTLPE AAAVVALRSR VLTDLAGAGA MASVLSPEEP
LTQLLARWDG KITVAAVNGP ASAVVSGDTT AITELLITCE HENIDARAIP VDYPSHSPYM
EHIRHQFLDE LPELTPRPST IAMYSTVDGE PHDTAYDTTT MTADYWYRNI RNTVRFHDTV
AALLGAGEQV FLELSPHPVL TQAITDTVEQ AGGGGAAVPA LRKDRPDAVA FAAALGQLHC
HGISPSWNVL YCQARPLTLP TYAFQHQRYW LLPTAGDFSG ANTHAMHPLL DTATELAENR
GWVFTGRISP RTQPWLNEHA VESAVLFPGT GFVELALHVA DRAGYSSVNE LIVHTPLLLA
GHDTADLQIT VTDTDDMGRQ SLNIHSHPHI GHDNTTTGDE QPEWVLHASA VLTAQTTDHN
HLPLTPVPWP PPGTAAIEVD DFYDDLAAQG YNYGPTFQGV QRIWRDHATP DVIYAEVELP
EDTDIDGYGI HPALFDAALH PLLALTQPPT NDTDDTNTAD TGDQVRLPYA FTGISLHATH
ATRLRVRLTR TGADAITVHT SDTTGAPVAI IDSLITRPLT TATGSAPATT AAGLLHLSWP
PHPDTTTDTD TDTDALRYRV IAEPTQQLPR YLHDLHTSTD LHTSTTEADV VVWPVPVPSN
EELQAHQASD TAVSSRIHTL TRQTLTVVQD WLTHPDTTGT RLVIVTRHGV STSAHDPVPD
LAHAAVWGLI RSAQNEHPGR FTLLDTDDNT NSDTLTTALT LPTRENQLAI RRDTIHIPRL
TRHSSDGALT APVVVDPEGT VLITGGTGTL GALFAEHLVS AHGVRHLLLT SRRGPQAHGA
TDLQQRLTDL GAHVTITACD ISDPEALAAL VNSVPTQHRL TAVVHTAAVL ADTPVTELTG
DQLDQVLAPK IDAAWQLHQL TYEHNLSAFI MFSSMAGMIG SPGQGNYAAA NTALDALADY
RHRLGLPATS LAWGYWQTHT GLTAHLTDVD LARMTRLGLM PIATSHGLAL FDAALATGQP
VSIPAPINTH TLARHARDNT LAPILSALIT TPRRRAASAA TDLAARLNGL SPQQQQQTLA
TLVAAATATV LGHHTPESIS PATAFKDLGI DSLTALELRN TLTHNTGLDL PPTLIFDHPT
PHAVAEHLLE QIPGIGALVP APVVIAAGRT EEPVAVVGMA CRFPGGVASA DQLWDLVIAG
RDVVGNFPAD RGWDVEGLFD PDPDAVGKTY TRYGAFLDDA AGFDAGFFGI SPREARAMDP
QQRLLLEVCW EALETAGIPA HTLAGTSTGV FAGAWAQSYG ATNSDDAEGY AMTGGATSVM
SGRIAYTLGL EGPAITVDTA CSSSLVAIHL ACQSLRNNES QLALAGGVTV MSTPAVFTEF
SRQRGLAPDG RCKAFAATAD GTGFGEGAAV LVLERLSEAR RNNHPVLAIV AGSAINQDGA
SNGLTAPHGP SQQRVINQAL ANAGLTHDQV DAVEAHGTGT TLGDPIEASA LHATYGHHHT
PDQPLWLGSI KSNIGHTQAA AGAAGVVKMI QAITHATLPA TLHVDQPSPH IDWSSGTVRL
LTEPIQWPNT DHPRTAAVSS FGISGTNAHL ILQQPPTPDT TQTPNTTTGS DPAVGSDPAV
GVLVWPLSAR SAPGLSAQAA RLYQHLSAHP DLDPIDVAHS LATTRSHHPH RATITTSIEH
HSENNHDTTD ALAALHALAN NGTHPLLSRG LLTPQGPGKT VFVFPGQGSQ YPGMGADLYR
QFPVFAHALD ACDAALQPFT GWSVLAVLHD EPEAPSLERV DVVQPVLFSV MVSLAALWRW
AGITPDAVIG HSQGEIAAAH VAGALTLPEA AAVVALRSRV LTDLAGAGAM ASVLSPEEPL
TQLLARWDGK ITVAAVNGPA SAVVSGDTTA ITELLITCEH ENIDARAIPV DYPSHSPYME
HIRHQFLDEL PELTPRPSTI AMYSTVDGEP HDTAYDTTTM TADYWYRNIR NTVRFHDTVA
ALLGAGEQVF LELSPHPVLT QAITDTVEQA GGGGAAVPAL RKDRPDAVAF AAALGQLHCH
GISPSWNVLY CQARPLTLPT YAFQHQRYWL LPTAGDFSGA NTHAMHPLLD TATELAENRG
WVFTGRISPR TQPWLNEHAV ESAVLFPGTG FVELALHVAD RAGYSSVNEL IVHTPLLLAG
HDTADLQITV TDTDDMGRQS LNIHSRPHIG HDNTTTGDEQ PEWVLHASAV LTAQTTDHNH
LPLTPVPWPP PGTAAIEVDD FYDDLAAQGY NYGPTFQGVQ RIWRDHATPD VIYAEVELPE
DTDIDGYGIH PALFDAALHP LLALTQPPTN DTDDTNTADT GDQVRLPYAF TGISLHATHA
TRLRVRLTRT GADAITVHTS DTTGAPVAII DSLITRPLTT ATGSAPATTA AGLLHLSWPP
HPDTTTDTDT DTDALRYQVI AEPTQQLPRY LHDLHTSTDL HTSTTEADVV VWPVPVPSNE
ELQAHQASDT AVSSRIHTLT RQTLTVVQDW LTHPDTTGTR LVIVTRHGVS TSAHDPVPDL
AHAAVWGLIR SAQNEHPGRF TLLDTDDNTN SDTLTTALTL PTRENQLAIR RDTIHIPRLT
RHSSDGALTA PVVVDPEGTV LITGGTGTLG ALFAEHLVSA HGVRHLLLTS RRGPQAHGAT
DLQQRLTDLG AHVTITACDI SDPEALAALV NSVPTQHRLT AVVHTAAVLA DTPVTELTGD
QLDQVLAPKI DAAWQLHQLT YEHNLSAFIM FSSMAGMIGS PGQGNYAAAN TALDALADYR
HRLGLPATSL AWGYWQTHTG LTAHLTDVDL ARMTRLGLMP IATSHGLALF DAALATGQPV
SIPAPINTHT LARHARDNTL APILSALITT PRRRAASAAT DLAARLNGLS PQQQQQTLAT
LVAAATATVL GHHTPESISP ATAFKDLGID SLTALELRNT LTHNTGLDLP PTLIFDHPTP
HAVAEHLLEQ IPGIGALVPA PVVIAAGRTE EPVAVVGMAC RFPGGVASAD QLWDLVIAGR
DVVGNFPADR GWDVEGLFDP DPDAVGKTYT RYGAFLDDAA GFDAGFFGIS PREARAMDPQ
QRLLLEVCWE ALETAGIPAH TLAGTSTGVF AGAWAQSYGA TNSDDAEGYA MTGGATSVMS
GRIAYTLGLE GPAITVDTAC SSSLVAIHLA CQSLRNNESQ LALAGGVTVM STPAVFTEFS
RQRGLAPDGR CKAFAATADG TGFGEGAAVL VLERLSEARR NNHPVLAIVA GSAINQDGAS
NGLTAPHGPS QQRVINQALA NAGLTHDQVD AVEAHGTGTT LGDPIEASAL HATYGHHHTP
DQPLWLGSIK SNIGHTQAAA GAAGVVKMIQ AITHATLPAT LHVDQPSPHI DWSSGTVRLL
TEPIQWPNTD HPRTAAVSSF GISGTNAHLI LQQPPTPDTT QTPNTTTGSD PAVGSDPAVG
VLVWPLSARS APGLSAQAAR LYQHLSAHPD LDPIDVAHSL ATTRSHHPHR ATITTSIEHH
SENNHDTTDA LAALHALANN GTHPLLSRGL LTPQGPGKTV FVFPGQGSQY PGMGADLYRQ
FPVFAHALDE VAAALNPHLD VALLEVMFSQ QDTAMAQLLD QTFYAQPALF ALGTALHRLF
THAGIHPDYL LGHSIGELTA AYAAGVLSLQ DAATLVTSRG RLMQSCTPGG TMLALQASEA
EVQPLLEGLD HAVSIAAING ATSIVLSGDH DSLEQIGEHF ITQDRRTTRL QVSHAFHSPH
MDPILEQFRQ IAAQLTFSAP TLPILSNLTG QIARHDQLAS PDYWTQQLRN TVRFHDTVAA
LLGAGEQVFL ELSPHPVLTQ AITDTVEQAG GGGAAVPALR KDRPDAVAFA AALGQLHCHG
ISPSWNVLYC QARPLTLPTY AFQHQRYWLL PTAGDFSGAN THAMHPLLDT ATELAENRGW
VFTGRISPRT QPWLNEHAVE SAVLFPGTGF VELALHVADR AGYSSVNELI VHTPLLLAGH
DTADLQITVT DTDDMGRQSL NIHSRPHIGH DNTTTGDEQP EWVLHASAVL TAQTTDHNHL
PLTPVPWPPP GTAAIEVDDF YDDLAAQGYN YGPTFQGVQR IWRDHATPDV IYAEVELPED
TDIDGYGIHP ALFDAALHPL LALTQPPTND TDDTNTADTG DQVRLPYAFT GISLHATHAT
RLRVRLTRTG ADAITVHTSD TTGAPVAIID SLITRPLTTA TGSAPATTAA GLLHLSWPPH
PDTTTDTDTD TDALRYQVIA EPTQQLPRYL HDLHTSTDLH TSTTEADVVV WPVPVPSNEE
LQAHQASDTA VSSRIHTLTR QTLTVVQDWL THPDTTGTRL VIVTRHGVST SAHDPVPDLA
HAAVWGLIRS AQNEHPGRFT LLDTDDNTNS DTLTTALTLP TRENQLAIRR DTIHIPRLTR
HSSDGALTAP VVVDPEGTVL ITGGTGTLGA LFAEHLVSAH GVRHLLLTSR RGPQAHGATD
LQQRLTDLGA HVTITACDIS DPEALAALVN SVPTQHRLTA VVHTAAVLAD TPVTELTGDQ
LDQVLAPKID AAWQLHQLTY EHNLSAFIMF SSMAGMIGSP GQGNYAAANT ALDALADYRH
RLGLPATSLA WGYWQTHTGL TAHLTDVDLA RMTRLGLMPI ATSHGLALFD AALATGQPVS
IPAPINTHTL ARHARDNTLA PILSALITTP RRRAASAATD LAARLNGLSP QQQQQTLATL
VAAATATVLG HHTPESISPA TAFKDLGIDS LTALELRNTL THNTGLDLPP TLIFDHPTPH
ALTQHLHTRL TQSHTPVGPI ASLLSHAIDE GKFRAGADLL MAASNLNQSF SNMAELNQLP
AVTDIADASP DGLLTLICIS TSENEYARLA AANIHSLTFA EIAAPGFYDA QLPNSIETSA
EALATAITGA YANTSIVLVA HSIVCELAQA TMTRLQDADI DLVGLVLLDP LEGTNSTEDY
VETVLTRIEH INAPRVGVDG YLAALGRYLQ FHEDRRIPIP ETRHMTLHSD TKIDRAQTPM
NLLQDEAALT ALKIGNWMND VGVALSVNLE
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