ID   Q6MZA5_MYCUA            Unreviewed;      2410 AA.
AC   Q6MZA5;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   19-JAN-2010, entry version 41.
DE   SubName: Full=Type I modular polyketide synthase;
GN   Name=mlsA2; OrderedLocusNames=MUP039c;
OS   Mycobacterium ulcerans (strain Agy99).
OG   Plasmid pMUM001.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=362242;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15758215; DOI=10.1099/mic.0.27674-0;
RA   Stinear T.P., Pryor M.J., Porter J.L., Cole S.T.;
RT   "Functional analysis and annotation of the virulence plasmid pMUM001
RT   from Mycobacterium ulcerans.";
RL   Microbiology 151:683-692(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14736915; DOI=10.1073/pnas.0305877101;
RA   Stinear T.P., Mve-Obiang A., Small P.L.C., Frigui W., Pryor M.J.,
RA   Brosch R., Jenkin G.A., Johnson P.D.R., Davies J.K., Lee R.E.,
RA   Adusumilli S., Garnier T., Haydock S.F., Leadlay P.F., Cole S.T.;
RT   "Giant plasmid-encoded polyketide synthases produce the macrolide
RT   toxin of Mycobacterium ulcerans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:1345-1349(2004).
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DR   EMBL; BX649209; CAE46850.1; -; Genomic_DNA.
DR   RefSeq; YP_025561.1; -.
DR   GeneID; 2846549; -.
DR   GenomeReviews; BX649209_GR; MUP039c.
DR   KEGG; mul:MUP039c; -.
DR   BuruList; MUP039c; -.
DR   HOGENOM; HBG669988; -.
DR   OMA; RRDIREA; -.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:InterPro.
DR   InterPro; IPR001227; Ac_transferase_dom.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPlipase.
DR   InterPro; IPR013154; ADH_GroES-like.
DR   InterPro; IPR013149; ADH_Zn-bd.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR011032; GroES-like.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR006163; Phsphopanteth_bd.
DR   InterPro; IPR020842; PKS/FAS_KR.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_reg.
DR   InterPro; IPR020807; PKS_dehydratase.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR006162; PPantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   Gene3D; G3DSA:3.40.366.10; Ac_transferase_reg; 1.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 2.
DR   Gene3D; G3DSA:3.40.47.10; Thiolase-like_subgr; 2.
DR   PANTHER; PTHR11712; Ketoacyl_synth; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 1.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Complete proteome; Phosphopantetheine; Plasmid; Transferase.
SQ   SEQUENCE   2410 AA;  256284 MW;  809EE15E0C6BFF14 CRC64;
     MVSTEENLRV YLKQVITDLH QMQARLRKIE KQRSERVAVV GMACRFPGGV ASADQLWDLV
     IAGRDVVGNF PADRGWDVEG LFDPDPDAVG KTYTRYGAFL DDAAGFDAGF FGISPREARA
     MDPQQRLLLE VCWEALETAG IPAHTLAGTS TGVFVGAWAQ SYGATNSDGA EGYAMTGGST
     SVMSGRIAYT LGLEGPAITV DTACSSSLVA IHLACQSLRN NESQLALAGG VTVMSTPAVF
     TEFSRQRGLA PDGRCKAFAA TADGTGWGEG AAVLVLERLS EARRNNHPVL AIVAGSAINQ
     DGASNGLTAP HGPSQQRVIN QALANAGLTH DQVDAVEAHG TGTTLGDPIE ASALHATYGH
     HHTPDQPLWL GSIKSNIGHT QAAAGAAGVV KMIQAITHAT LPATLHVDQP SPHIDWSSGT
     VRLLTEPIQW PNTDHPRTAA VSSFGISGTN AHLILQQPPT PDTTQTPNTT TGSDPAVGSD
     SAVGSDPAVG VLVWPLSARS APGLSAQAAR LYQHLSAHPD LDPIDVAHSL ATTRSHHPHR
     ATITTSIEHH SENNHDTTDA LAALHALANN GTHPLLSRGL LTPQGPGKTV FVFPGQGSQY
     PGMGADLYRQ FPVFAHALDE VAAALNPHLD VALLEVMFSQ QDTAMAQLLD QTFYAQPALF
     ALGTALHRLF THAGIHPDYL LGHSIGELTA AYAAGVLSLQ DAATLVTSRG RLMQSCTPGG
     TMLALQASEA EVQPLLEGLD HAVSIAAING ATSIVLSGDH DSLEQIGEHF ITQDRRTTRL
     QVSHAFHSPH MDPILEQFRQ IAAQLTFSAP TLPILSNLTG QIARHDQLAS PDYWTQQLRN
     TVRFHDTVAA LLGAGEQVFL ELSPHPVLTQ AITDTVEQAG GGGAAVPALR KDRPDAVAFA
     AALGQLHCHG ISPSWNVLYC QARPLTLPTY AFQHQRYWLL PTAGDFSGAN THAMHPLLDT
     ATELAENRGW VFTGRISPRT QPWLNEHAVE SAVLFPGTGF VELALHVADR AGYSSVNELI
     VHTPLLLAGH DTADLQITVT DTDDMGRQSL NIHSHPHIGH DNTTTGDEQP EWVLHASAVL
     TAQTTDHNHL PLTPVPWPPP GTAAIEVDDF YDDLAAQGYN YGPTFQGVQR IWRDHATPDV
     IYAEVELPED TDIDGYGIHP ALFDAALHPL LALTQPPTND TDDTNTADTG DQVRLPYAFT
     GISLHATHAT RLRVRLTRTG ADAITVHTSD TTGAPVAIID SLITRPLTTA TGSAPATTAA
     GLLHLSWPPH PDTTTDTDTD TDALRYQVIA EPTQQLPRYL HDLHTSTDLH TSTTEADVVV
     WPVPVPSNEE LQAHQASDTA VSSRIHTLTR QTLTVVQDWL THPDTTGTRL VIVTRHGVST
     SAHDPVPDLA HAAVWGLIRS AQNEHPGRFT LLDTDDNTNS DTLTTALTLP TRENQLAIRR
     DTIHIPRLTR TAVLTPPDSG PWRLDTTGKG DLANLALLPT AHTALASGQI RIDVRAAGLN
     FHDVVVALGL IPDDGFGGEA AGVISEIGPD VYGFAVGDAV TGMTVSGAFA PSTVADHRMV
     MTIPARWSFP QAASIPVVFL TAYIALAEIS GLSRGQRVLI HAGTGGVGMA AIQLAHHLGA
     EVFATASAAK WSTLEALGVP RDHIASSRTL DFSNAFLDAT NGAGVDVVLN CLSGEFVEAS
     LALLPRGGHF VEIGKTDIRD TEVIAATHPG VIYRALDLLS VSPDHIQRTL AQLSPLFATD
     TLKPLPTTNY SIYQAISALR DMSQARHTGK IVLTAPVVVD PEGTVLITGG TGTLGALFAE
     HLVSAHGVRH LLLTSRRGPQ AHGATDLQQR LTDLGAHVTI TACDISDPEA LAALVNSVPT
     QHRLTAVVHT AAVLADTPVT ELTGDQLDQV LAPKIDAAWQ LHQLTYEHNL SAFIMFSSMA
     GMIGSPGQGN YAAANTALDA LADYRHRLGL PATSLAWGYW QTRTGVTAHL TDVDLARMTR
     LGLMPIATSH GLALFDAALA TGQPVSIPAP INTHTLARHA RDNTLTPILS ALITTPRRRA
     ASAATDLAAR LNGLSPQQQQ QTLATLVAAA TATVLGHHTP ESISPATAFK DLGIDSLTAL
     ELRNTLTHNT GLDLPPTLIF DHPTPHALTQ HLHTRLTQSH TPVGPIASLL SHAIDEGKFR
     AGADLLMAAS NLNQSFSNMA ELNQLPAVTD IADASPDGLL TLICISTSEN EYARLAAANI
     HSLTFAEIAA PGFYDAQLPN SIETSAEALA TAITGAYANT SIVLVAHSIV CELAQATMTR
     LQDADIDLVG LVLLDPLEGT NSTEDYVETV LTRIEHINAP RVGVDGYLAA LGRYLQFHED
     RRIPIPETRH MTLHSDTKID RAQTPMNLLQ DEAALTALKI GNWMNDTGSI AVTLRDGPVF
     LGRARSVNMR
//