ID   Q6W5P9_9ACTO            Unreviewed;      5541 AA.
AC   Q6W5P9;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   19-JAN-2010, entry version 39.
DE   SubName: Full=FscB;
GN   Name=fscB;
OS   Streptomyces sp. FR-008.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=206662;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=14652074; DOI=10.1016/j.chembiol.2003.10.007;
RA   Chen S., Huang X., Zhou X., Bai L., He J., Jeong K.J., Lee S.Y.,
RA   Deng Z.;
RT   "Organizational and Mutational Analysis of a Complete FR-
RT   008/Candicidin Gene Cluster Encoding a Structurally Related Polyene
RT   Complex.";
RL   Chem. Biol. 10:1065-1076(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RA   Chen S., Huang X., Zhou X., He J., Bai L., Jeong K.J., Lee S.Y.,
RA   Deng Z.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AY310323; AAQ82565.1; -; Genomic_DNA.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:InterPro.
DR   InterPro; IPR001227; Ac_transferase_dom.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPlipase.
DR   InterPro; IPR013154; ADH_GroES-like.
DR   InterPro; IPR013149; ADH_Zn-bd.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR011032; GroES-like.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR006163; Phsphopanteth_bd.
DR   InterPro; IPR020842; PKS/FAS_KR.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_reg.
DR   InterPro; IPR020807; PKS_dehydratase.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR006162; PPantetheine_attach_site.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   Gene3D; G3DSA:3.40.366.10; Ac_transferase_reg; 3.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 4.
DR   Gene3D; G3DSA:3.40.47.10; Thiolase-like_subgr; 6.
DR   PANTHER; PTHR11712; Ketoacyl_synth; 1.
DR   Pfam; PF00698; Acyl_transf_1; 3.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF00109; ketoacyl-synt; 3.
DR   Pfam; PF02801; Ketoacyl-synt_C; 3.
DR   Pfam; PF08659; KR; 3.
DR   Pfam; PF00550; PP-binding; 3.
DR   SMART; SM00827; PKS_AT; 3.
DR   SMART; SM00826; PKS_DH; 2.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00822; PKS_KR; 3.
DR   SMART; SM00825; PKS_KS; 3.
DR   SMART; SM00823; PKS_PP; 3.
DR   PROSITE; PS50075; ACP_DOMAIN; 3.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 3.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   4: Predicted;
KW   Phosphopantetheine; Transferase.
SQ   SEQUENCE   5541 AA;  576548 MW;  E901D0BE12B0E932 CRC64;
     MSNEDRLRAY LKRAVTDLQE ARQQLSDAEN RDREPVAVVA MACRYPGGVR TPQDLWELAR
     DGVDAISAFP ANRGWDLDHL FHPDPAHHGT TYTREGGFLH DAGEFDPAFF GISPREALAM
     DPQQRLLLET SWEALERAGI LPDTLAGSTT GVFVGTGHGD YDGASRGRQK EVAGHLLTGN
     TVAVASGRLS YTYGFEGPAV TVDTACSSSL VALHLAVRSL RQGECSLALA GGATVMSTPK
     MFTEFSRQQG LAADGRCKPF AAGADGTAWS EGVGLILLER LSDAQRNGHE ILAVIRGSAI
     NQDGASNGLT APNGPSQQRL IRQALIDAGL TSGEVDVVEA HGTGTTLGDP IEAQALLNTY
     GQDRGDAHPL LLGSLKSNTG HTQAASGVAG VIKMVQAMRH GTLPKSLHVD APTPHADWAT
     GGVELLTEST TWPETGRPRR AAVSSFGVSG TNAHLILEQA PEDQTPRAEE PGTEPSADDS
     ADTVRSWMVS GKSRAAVGEQ AARLAASVRA SDASVLDVAH ALVSSRVAMD RRAVVVGSDR
     EELLAGLDAL AAGEPSVRVV EGTAGEGAGD VAFVFPGQGS QWVGMAVELL GSSPVFAGRV
     AECAAALEPF TEWSLLDVLN GVEGAASLER VDVVQPVLWA VMVSLAEVWR AQGVEPGAVI
     GHSQGEIAAA VVAGGLSLED GARVVALRSR ALRALSGLGG MVSVARNVDE VRGLLAGWEG
     RISVAAVNGP SSVVVSGDAE ALDEFVAACD ASGVRARRVA VDYASHSAHV ERIEEELAGL
     LAPVAPRSCD VPFYSTLSGG VIDTAGLDAG YWYRNLRGTV EFEAGTRALL ADGFRVFVEV
     SAHPVVATGV QETIEDASVQ AGVVGTLRRD EGGLERFALS LGEAWALGAE VDWETHYAGT
     RPRHVDLPTY PFRRDWYWLT PAESAAAAAT GDPADGDFWS AVESGDLTRL SSVLEVTGDD
     VEAFGTLLPA LASWRRRRTL RSTLDTWRHR VTWTALTGAD DAVPAGRWPA LVPAGHADDP
     WVHAVLGALT GRGLRVERHD LTGDEDTAAL TALLTGTGDT EPDGAEGIAG VLSLLALDER
     PHPDHPAVPR GLATAKELLH ALSGTEASVW ALTRGAVAVD SRDRLTSPVQ AETWGFGRAV
     ALELPDAWGG LADLPADPDA RSLARLATLL GGPEDQIAVR SSGAYARRLA RMPLPEPARV
     TDVDAELAVR AADDDGIGGW GDHDTVLITG GTGALGAHVA RSLAASGARH LVLTSRRGPG
     SPGAVGLVAE LEELGARVTV ADCDVADRDQ LARLLDSLPA GLPLTGVVHA AGVLDDGVLD
     ALTLDRFEAV LRPKTLGTAH LHELTRDHDV TLFVLFSSIV GVLGNAGQAN YAAANAYLDA
     VAEQRRAEGL PVTSVAWGPW ADAGMATADV LADRMSHDGL APMDPVTAVA ALRAAVAEGV
     PHATVLDVDW RAYGTAMTAA RPSPLVGDLP EVRRALEAAA ATAPDTHALR DRLRGLAPAE
     QDRLLTDLVR AEVATALRHS SPEAVDVNRA FKDLGFDSLT AVEVRNRITA ATDVKLPTTL
     LFDYPNTTAV VAHLRTLLLG DERPVAAPVV VSAGVTDEPM AVVAMACRFP GGVTTPEELW
     HLMAAEVDAV STPPEDRGWD LDALYDPDPE RHGTTYSREG GFIQDVAGFD PVFFGISPRE
     ALAMDPQQRL LLETSWETFE RAGIDPGTLR NSATGVFVGS ITTDYQVRLG GAAAQEQLAG
     HLMTGNASSI ASGRLSYTYG FEGPAVTMDT GCSSSMVALH LALQSLRTGE CTMALAGGVT
     VMSTPEPYVE FSRQRGLAAD GRCKAFAEGA DGMGFAEGVG LVLLERLSDA RRNGHPVLAV
     VRGSALNQDG ASNGLTAPNG PSQQRVIRQA LANAGLAPGE VDVVEAHGTG TPLGDPIEAQ
     AILATYGQDR DPARPLLLGS LKSNIGHTQA AAGVAGMMKM ILAMRQGTLP KSLHITRPTS
     VVDWSSGAVR LVTESTPWPE TGRPRRAGVS SFGISGTNGH LILEEAPAPE PAEDEPADPF
     TEPSADDSAD TVRSWMVSGK SRAAVGEQAA RLAASVRTSD ASVLDVAHAL VSSRVAMDRR
     AVVVGRDGEE LLAGLDALAA GEPSPRLVEG SVGDGSGKVA FVFPGQGSQW VGMAVELLGS
     SPVFAGRVAE CAAALEPFTE WSLLDVLNGV EGAASLERVD VVQPVLWAVM VSLAEVWRAQ
     GVEPGAVIGH SQGEIAAAVV AGGLSLEDGA RVVALRSRAL RALSGLGGMV SVARNVDEVR
     GLLAGWEGRI SVAAVNGPSS VVVSGDAEAL DEFVAACDAS GVRARRVAVD YASHSAHVER
     IEEELAGLLA PVAPRSCDVP FYSTLSGGVI DTAGLDAGYW YRNLRGTVEF EAGTRALLAD
     GFRVFVEVSA HPVVATGVQE TIEDASVQAG VVGTLRRDEG GLERFALSLG EAWALGAEVD
     WETHYAGTRP RHVDLPTYAF QRQHYWPRFA ELGGDVSSAG LDSPDHPLLG ASVELAGGDG
     LVATARWSLR THPWLADHAV SGTVIVPGTA LVESVIRAGD VLGCGRIEEL ALQAPVVLQE
     RGEAQVQIGV GEPDASGRRP VTVHTRTTGP DGATEDLWTL RAQGTLTEPG APAVDRPEEF
     TSWPPPGATA VAAEGFYELL AGRGYEFGPV FQGVRATWSR GEDLYAEVVL PEQVRGDAGR
     FGIHPALLDA ALHAAHLAPG SAGRTVVPFT WSGVCLHAAG ATALRVRVSP AGQDAISVQL
     TDPTGAPVAT IDALAVREIA PDTLDPSARA ARDWLFRLDW TPVTPPAAVP AATGWAVLGT
     PADPVTAPDG SGTTLPAFAT PGALAEHTEA NGHRPDAVLL FAGAAASGTA AAPDAEPGVP
     DAVLDDVLAT VQSWLADETT EGVPLVVVTR GAVPTGPADP AHDLPGAAVW GLVRSAQSQH
     PGRLVLVDLD IHDDSWLALP AALAAGEPQL ALRQGAAYAP RLVRPRTSDA LTVPEGTGNW
     RLDIPEKGSV DRLDLVAAPG TAEEPAAGEV VIEVRAAGLN FRDVLNTLGM YPGPAVLLGA
     EAAGVVTAVG EGVTGFAPGD RVMGLVSGGF APRAVADARM LAPVPDGWTW AQAASVPVAF
     LTAYYGLRDL AHLDAGESVL VHAAAGGVGM AAAQLARHWG AEVYGTAGDH KRTLLRADGW
     DDAHLASSRT LAFEDRFRTT SGGRGVDVVL NSLAGDYIDA SLRLLAPGGR LVDMGKTDVR
     DPGQVLRDHP AAALYQAYEL REAGEDRIQE MFRDLSELFA SGALRPLPTV TWDVRHAREA
     FRHMAQAKHY GKIVLTLPRA WDPEGTVLVT GGAGVLGGIL ARHLVTRHGM RHLVLTGRRG
     PDTPGAGELA AELRELGAEV TLAACDAADA DALAAVLAAV PAEHPLTAVV HAAGVLDDGV
     LESLTPDRLR TVLAPKADAA RHLHRLTRDL DLTDLVLFSA GAGVFGNAGQ ANYAAANTYL
     DALAHRRRAD GLPTTSLSWG LWADTSALTG QLDDTDLARV RRSGVLPLSA ADGMVLFDAA
     LTEQRPHLVP VRLETGQLRA SGDEVPPLLR SLYRGPVRRT AEAGAATGTD GLRARLAGRS
     AEDRLSTLRD LVGAHAAAVL GHDDTEPFHA GRAFRDLGFD SLTAVELRNR LSAATGLRLP
     ATLVFDHPTV AALAAHLDGE LSDGTPAALP AAPAPAPAAP GDDDPFAIVG MACRLPGDIH
     SPEDLWRLLA DGADAVAPFP DDRGWDLARL YDSVPEGQGS SRTREGGFLH DAADFDADFF
     GISPREALAM DPQQRLLLET AWETFERAGI DPRSVRGSRT GVFAGLSSSD YLKRVTHVPD
     EIAGYVNNGN ANSIVSGRVS YTLGLEGPAV TVDTACSSSL VALHMALQAL RRGECTMALA
     GGVTVMSSPE IIVDFSRQRG LAADGRCKPF AEAADGTGFS EGVGLILVER LSDARRNGHQ
     VLAVVRGSAV NQDGASNGLS APNGPAQQRV IRQALADAGV GAAEVDVVEA HGTGTRLGDP
     IEAQALLATY GRDRDGGHPL FLGSVKSNLG HTQAAAGVAG VMKMVLALRH RLLPESLHID
     APTPHVDWAD SGVRLLTEAT AWPEAGASRP RRAAVSSFGI SGHQRPRHPG GGPPPPPART
     AASRSPPAPD AAETRPAPLP WVLSARSEAA LRGQAKALLT HLDAHPGTDP ADIAHTLVTR
     RAQLEKRAVV VGSATGDFRA GLAALAEGSP AAHVVTGGRG AGRDRRTVLV FPGQGSQWAG
     MGAELLDASP AFADRVAACE EALAPYVDWS LTAVLRQEEG APALDRVDVV QPVTWAVMVA
     LAEVWRAHGL RPAAVLGHSQ GEIAAAAVAG ALSLADAARI VAVRSRAIAR ELSGHGGMVA
     VTAPHDEVTA LLADLPGVCV AAVNGPSSVV VSGDTGGLDT LLAACEEQGV RARRVPVDYA
     SHSAHVDRLA ESLPAALDGI EPRDGDIPFF STVTADWHPG TGLGAAYWHR NLRGTVRLEE
     SLRALVEQGH DVFVECGPHP VLTVGIEDTV AALGADAVAL GSLRRDDGGP ARVLTALAAA
     HVEGVPVDWR PAVSHGTAVD LPTYAFQRRR YWLDAGTPQG DPAGLDSVVR LADGGAVLSG
     SLSLTTQPWL DAHRTHGAAV VPTTALLDWA VRAGDETGLP VVAALDEHSP LVVPEEGHVE
     IQLTVSAADT DSRPFSVHSR LHAADAGEPA TPWTRNATGD LTDRPTTTPQ ASGTWPPADA
     VAADPAPVRA LAEDRGLDLA APFDTVRSLW RAGTDVLAEV ALPDAAHADA ARFRLHPALL
     QTPLALAATT EEATAPVLPA AWRDVTVHAT GASRLRVRLT PGDDATWSVE ARDAAGDLVL
     TGTAVTRSAG PDRLPATAGP DAPHRVAWLP WTDTTSSATP EPHGPWAVIG APGRLTAALE
     RSGATVQLHP DLAALTTALD NDEAAPPALV VAFHGHDSGE DPTKAAHTSA ARALTLSTAW
     LREPRLADAR LLLVTEGAVA TGPDDTVPGL ADATAWGLLR SAQTEHPGRF LLADLDPAPG
     DTDEDSAADA LIAAAAAAAR TGEHQFAVRA GTVTVPRLVP AGHPEGAPAP AATAPWGEGT
     GAGTVLITGG TGTLGALVAR HLVTRHGVRH LLLTSRRGPG APGAAALREE LAALGAEAEI
     VACDVADREQ LAGVLDAVPA EHPLTAVVHT AGVLDDGTLD GLTADRVAHV LRPKADAAWH
     LHELTRDTKL TAFVMFSSYA GVAGGPGQAN YAAANAFLDA LAQHRRASGL PAHSLAWGLW
     EDRSDLTGAL DTTGLARLER SGIRPLTAGQ GLALLDASTA LDTAHLVPVR LDTRTLRADE
     VPPLLRALAR PAVRRAADSG PGAATGAPAD LRERLAGLSG PQQRALLHRT VLGHLAAVLG
     HASAASLDAD RGFLDLGMSS LTAVELRNRL NADTGLSLPT TLIFDHPDPA ALVRHLQTEL
     GTGAGEPDQA VFAELAALEA AVGGAALDDQ DRARLAQRLK ALGWKLDATS QDADEPDDDS
     DLDTTTDDEM FDLIDNELGL A
//