ID   Q8KUF5_ACTPA            Unreviewed;      1589 AA.
AC   Q8KUF5;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   19-JAN-2010, entry version 43.
DE   SubName: Full=Polyketide synthase;
GN   Name=asmC;
OS   Actinosynnema pretiosum subsp. auranticum.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Pseudonocardineae; Actinosynnemataceae; Actinosynnema.
OX   NCBI_TaxID=42198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 31565;
RX   MEDLINE=22056096; PubMed=12060743; DOI=10.1073/pnas.092697199;
RA   Yu T.W., Bai L., Clade D., Hoffmann D., Toelzer S., Trinh K.Q., Xu J.,
RA   Moss S.J., Leistner E., Floss H.G.;
RT   "The biosynthetic gene cluster of the maytansinoid antitumor agent
RT   ansamitocin from Actinosynnema pretiosum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:7968-7973(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 31565;
RA   Yu T.-W., Bai L., Clade D., Hoffmann D., Toelzer S., Trinh K.Q.,
RA   Xu J., Moss S.J., Leistner E., Floss H.G.;
RL   Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AF453501; AAM54077.1; -; Genomic_DNA.
DR   HSSP; P43677; 1NQ4.
DR   SMR; Q8KUF5; 6-891, 950-1395, 1139-1503.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   InterPro; IPR001227; Ac_transferase_dom.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPlipase.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR006163; Phsphopanteth_bd.
DR   InterPro; IPR020842; PKS/FAS_KR.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_reg.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR006162; PPantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   Gene3D; G3DSA:3.40.366.10; Ac_transferase_reg; 1.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:3.40.47.10; Thiolase-like_subgr; 2.
DR   PANTHER; PTHR11712; Ketoacyl_synth; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 1.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine; Transferase.
SQ   SEQUENCE   1589 AA;  164713 MW;  5067CF9A772A525F CRC64;
     MTDGTHEKLV DYLRWVTADL HETRRKLADL ESAGHEPIAI TGLACRAPGG VRTPEALWEL
     VDGGVDAITG FPTDRGWDLA GLYDPDPTRP GTCYTREGGF LHDAAEFDAG FFGIGPREAV
     TIDPQHRMLL ETSWEAVERA GLDPLSLRGT GTGVFSGVVY QNYGNRRRVA EEFEGHLAIG
     SSGSVASGRV AYALGLHGPA ITVDTACSSS LVAIHLAAQS LRRGECAMAL AGGATVMPLS
     DVFVEFARQR GLSPDGRCKA FSADADGTAW GEGVGVVLLE RLSDARRAGR PVLAVIRGSA
     VNSDGASNGL TAPNGAAQQR VIEAALEDAG LRPSDVDLLE AHGTGTRLGD PIEAAALQAT
     YGRARPEGRP LLLGSLKSNI GHAQGAAGVL GLVKVVQALR HGVAPRTLHA DRLTPEVDWT
     SGALRVLTEP APWPRGERPR RAAVSAFGMS GTNAHLVVEE GDAPSAPGER RPAGALPLLL
     SARGGAALRA AAADLVELPG EPVDVCWSLL TGRARLVDRA VVVAADRAGF TAGLEALAAD
     RPSAAAVTGR ADVAGRTVLV FPGQGGQWVG MGARLLDESP VFAAAVARCA AAVEPLVDFR
     VVDALRGGDL GRVDVVQPVS FVLMVALARL WRSVGVEPDV VVGHSQGEIA AACVAGALSL
     EDAARVVVLR SRAIAAEAGG GGMASIPLPR AEVERLITGT GVSVAAVNGP GSVVVSGDVD
     PLVARVEGAR RLPVDYASHS PAVDVLRGRL LADLARVTPR PAAIPMLSTV TGKWLDGAEL
     DADYWFANLR EPVRFADAVT ELAGADCAAF VEVGAHPVLT AAIQDVLGER TAVVTGTLRR
     DDGGLDRFLR SAAALHVRGV PVDWAPVFEG LDARRADLPT YPFQRARHWL QEAEPDARQA
     GGDDPLWAAA RDADGLCAEL ELTEPDQRAA LRAVLPALTA WHERRSERAL LDSWRYRITW
     RTLPEPPESA PRGDWLVVGP HPDLLADLLP GAALDPGDAD RAALADLLRP HTAVAGVLAT
     PGADVLTLVQ ALGDAGATAP LWCATTGAVA ISPHDGPPDP AQAATWGLGR VVALEHPGRW
     GGLVDLADPA DPRQRRGLAA VLAGPGVDDG GEDQVAIRAQ GVFARRLVRA EPQAPAAPWT
     PRGTVLITGG TGGVAAHVAR RLAALGADHL VLTSRRGPSA PGAPALAADL EALGARVTTA
     ACDVADRAAL AALLTGLERA GEQVTAVVHA AGANAQTPVA DTTPEEHARV QAAKALGAEH
     LDELLGGRPL DAFVLFSSNA GVWGSGGQCA YAAANARLDA LAQRRRAHGR VATSVAWGAW
     DGGGMSSATP DIAAQLAQAG LRLMPPDLAV SALLDAVARD ESTTVVTDVR WEAFAARFTA
     LRRSPLLADL PEARPEPVAA TAEPDRGLAG ELAALPAPER LRRLTDLVRA HAAAALGHPG
     PESVPADVAF RDLGVDSLAA VELRNRACAA TGAKLTPTAV FDHPTPRALA EHLAEHLAAA
     RDSAAPDAAP DAEDPTSALR DLDALAAALP AAAGDDALRE RVTARLREVL GRWEELTGGP
     GGPDDLDLDH ISDDELFRLA DSRLGPTGA
//