ID   Q8KUF8_ACTPA            Unreviewed;       294 AA.
AC   Q8KUF8;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   19-JAN-2010, entry version 21.
DE   SubName: Full=Methyltransferase;
GN   Name=asm10;
OS   Actinosynnema pretiosum subsp. auranticum.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Pseudonocardineae; Actinosynnemataceae; Actinosynnema.
OX   NCBI_TaxID=42198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 31565;
RX   MEDLINE=22056096; PubMed=12060743; DOI=10.1073/pnas.092697199;
RA   Yu T.W., Bai L., Clade D., Hoffmann D., Toelzer S., Trinh K.Q., Xu J.,
RA   Moss S.J., Leistner E., Floss H.G.;
RT   "The biosynthetic gene cluster of the maytansinoid antitumor agent
RT   ansamitocin from Actinosynnema pretiosum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:7968-7973(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 31565;
RA   Yu T.-W., Bai L., Clade D., Hoffmann D., Toelzer S., Trinh K.Q.,
RA   Xu J., Moss S.J., Leistner E., Floss H.G.;
RL   Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent
CC       methyltransferase activity (By similarity).
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DR   EMBL; AF453501; AAM54088.1; -; Genomic_DNA.
DR   SMR; Q8KUF8; 19-282.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; LCM_MeTrfase.
DR   Pfam; PF04072; LCM; 1.
DR   TIGRFAMs; TIGR00027; CHP00027_methyltrans; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
SQ   SEQUENCE   294 AA;  30764 MW;  7AD7E3E5E6625AE6 CRC64;
     MSLPADSPPP GPVEMPDESW TSLGNAGARA QESARADRLF DDPLARAFLD AAGTGNPLLP
     DRGGGDPGLL GQITDVIVVK TVFFDAVLAR AAAAGVRQVV LLAAGLDARA FRLPWPEGVV
     VFEVDLPDVL GFKERVVREV GAEPSCDRRV VAADLRSDWV AALVAAGLDR EAPVAWLAEG
     ALGLLDEAGC EELMAAVLGA SAAGSRFALD HTHDGWKAGE ALGGYLEGTG VCLADLVKGG
     PREPGGAWLA RHGWRVAEYD VVAEAARHGR PAPTLFRVPE RRANATILFE AELG
//