ID   Q8KUG0_ACTPA            Unreviewed;       441 AA.
AC   Q8KUG0;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   19-JAN-2010, entry version 28.
DE   SubName: Full=Halogenase;
GN   Name=asm12;
OS   Actinosynnema pretiosum subsp. auranticum.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Pseudonocardineae; Actinosynnemataceae; Actinosynnema.
OX   NCBI_TaxID=42198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 31565;
RX   MEDLINE=22056096; PubMed=12060743; DOI=10.1073/pnas.092697199;
RA   Yu T.W., Bai L., Clade D., Hoffmann D., Toelzer S., Trinh K.Q., Xu J.,
RA   Moss S.J., Leistner E., Floss H.G.;
RT   "The biosynthetic gene cluster of the maytansinoid antitumor agent
RT   ansamitocin from Actinosynnema pretiosum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:7968-7973(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 31565;
RA   Yu T.-W., Bai L., Clade D., Hoffmann D., Toelzer S., Trinh K.Q.,
RA   Xu J., Moss S.J., Leistner E., Floss H.G.;
RL   Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AF453501; AAM54090.1; -; Genomic_DNA.
DR   SMR; Q8KUG0; 2-408.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR003042; Rng_hydrolase-like.
DR   InterPro; IPR006905; Trp_halogenase.
DR   Pfam; PF04820; Trp_halogenase; 2.
DR   PRINTS; PR00420; RNGMNOXGNASE.
PE   4: Predicted;
SQ   SEQUENCE   441 AA;  48155 MW;  0480F5FFA00A15DB CRC64;
     MLDAIVMGGG PAGSVCAAVL ARQGRSVLVL ERQEFPRFHI GESMLPYMVG LLERHGLLDA
     VREQGYVVKR GGEFIDPTGT KFFRAGVFRA DFAKTGDGRH HETFQVERSH FDRVNLDQAR
     AAGATVREGA QVVGLLEEGG RVVGVRYREG GVEREERARY VVDATGRAGV VANRFGLRRM
     IEDLRMVAVF HHRDGLDEAH NPGHEGDIQV GSHSDGWIWA IPLSADRISV GTVMHRDRLR
     GRTPAEAFAE HVERVPRINQ RLTGTSATSD FWVETDYSYH SDQVTGPGWV MVGDAGCFGD
     PMFSGGVLVG MATGAEAAEA LGRALDSPAD EEQALTGYSN FFKTGYDTYV RLIFSFYEGE
     LLPALAEAHS EAGNLSEADM EMYVVRLLGG DFWSARNPVA NALRANPAWS TFSPFEPVHR
     CPVYPELDVA ELGGLAGTVG R
//