ID   Q93TW9_STIAU            Unreviewed;      5192 AA.
AC   Q93TW9;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   19-JAN-2010, entry version 47.
DE   SubName: Full=MxaC;
GN   Name=mxaC;
OS   Stigmatella aurantiaca.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Cystobacteraceae; Stigmatella.
OX   NCBI_TaxID=41;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=21110452; PubMed=11182319; DOI=10.1016/S1074-5521(00)00056-9;
RA   Silakowski B., Nordsiek G., Kunze B., Blocker H., Muller R.;
RT   "Novel features in a combined polyketide synthase/non-ribosomal
RT   peptide synthetase: the myxalamid biosynthetic gene cluster of the
RT   myxobacterium Stigmatella aurantiaca Sga15.";
RL   Chem. Biol. 8:59-69(2001).
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DR   EMBL; AF319998; AAK57187.1; -; Genomic_DNA.
DR   HSSP; P25715; 1MLA.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   InterPro; IPR001227; Ac_transferase_dom.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPlipase.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR006163; Phsphopanteth_bd.
DR   InterPro; IPR020842; PKS/FAS_KR.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_reg.
DR   InterPro; IPR020807; PKS_dehydratase.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR006162; PPantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   Gene3D; G3DSA:3.40.366.10; Ac_transferase_reg; 3.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 3.
DR   Gene3D; G3DSA:3.40.47.10; Thiolase-like_subgr; 6.
DR   PANTHER; PTHR11712; Ketoacyl_synth; 1.
DR   Pfam; PF00698; Acyl_transf_1; 3.
DR   Pfam; PF00106; adh_short; 2.
DR   Pfam; PF00109; ketoacyl-synt; 3.
DR   Pfam; PF02801; Ketoacyl-synt_C; 3.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF00550; PP-binding; 3.
DR   SMART; SM00827; PKS_AT; 3.
DR   SMART; SM00826; PKS_DH; 2.
DR   SMART; SM00822; PKS_KR; 3.
DR   SMART; SM00825; PKS_KS; 3.
DR   SMART; SM00823; PKS_PP; 3.
DR   PROSITE; PS50075; ACP_DOMAIN; 3.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 3.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE   4: Predicted;
KW   Phosphopantetheine; Transferase.
SQ   SEQUENCE   5192 AA;  558291 MW;  7C7C4AE414A31D4E CRC64;
     MANRNDESNE LSPAKRMLVA LEKMQTRLNA VEGAAKEPIA IVGMACRFPQ ADNVEAFWRL
     LQGGVDAVRE IPLERWPKDE VADIGDGAMR WGGFLDSVDS FDPGFFGISP REAVRMDPQQ
     RLLLEVAWEA LEDAGLDVDK LSGSRSGVFI GACNDDYHCM QVERPETGDA FSATGVAASV
     LSGRLSYLFN LQGPSLVVDT ACSSSLVSLH LACQSLRNRE CNMALAGGVN LILSPQSVLL
     VSKLQALSPD GRSKAFDASA NGFTRGEGCG IVVLKRLSDA LADGDHILAT IRGSAINQDG
     KSTGLTTPNV LSQQALIRQA LESSGLKAEQ VSYVEAHGTG TPLGDPIEAE ALRETYGVPR
     PDGSVCGIGS VKTNVGHLES AAGIAGIMKV VLAMRHQSIP PHLHLKQVNP RIQLEGSALT
     IPTRLTPWKA SGQPRRAGVS SFGISGTNAH VIIEEAPAPV AKDALPQRPE VLPLSARSRE
     ALVALAERYA ERLGREGGGS LSDVCYTASA HRTHHTHRLA VLADSREHTA ERLRAFARGE
     QPSGAWSGRK AFGGRRKIVF VYPGQGAQRA GMGRALMESE PVFRDALVKV DKALQPHLGW
     SVLDEIAADE QRSRLAEIDV NQPVLFAVEV ALTALWRSWG IEPDAVMGHS MGEVVAAHVA
     GALSLEDAVL IICHRSKLMR TLGGRGATMA MVELSVEEAE EAIRPWNGKI WLGGLNGPRS
     QVLSGEPEAV KEAVEALGKR GVFTRWVKMD VPSHTPLVEV ISRELEGRIA RITPRAADIP
     LCSTVTGEFL DGAKLDAAHW GNNLRNPVRF AAAAQHLLAS DHGTFVEVSP HPVLLPAVEQ
     TMSAGNTEGV VLASLRRNED ERHTMLSSLG ALYSSGHRVA WNRVYPGKGQ LVPLPTYPWQ
     RERFWMEPAV RGVRASRTSS GHPLIGERID LSAQGEVSRL WQVQLGPKHF PLLAEHRVQG
     VPALPAAAMA DMALSAAKQT LGEPVSLEDV SFSALLSFPE DEERVLQLWL STERPGASAF
     RLFSAPVMRE TPSDELTWAL HAEGSLRHGD ASVVEKAAPV ALDELRARCG EEASVEAHYQ
     TLKEIGLEYG PSFRVVRELY RAKGEALGRV QLEGELTAEE ERYSLHPALL DGCFQVLAAA
     LEGLDSEGGV YVPVALSRLR VLVRPEAALW SHVRIVSGAE AGSNTIECDV TLLNDQGRVV
     AEVRRLVCKK IAAASAPADE VDRWIYSAQW EPQQRQARAE TGSSRTAGRW LVFADARGIG
     QSLASGLAER AGGCVVVEAG PSYERLEADR YRINPSKLED FQALLKEAFS DQSPCKGMVH
     LYGLDVASNV TEPESFERAL SLSSTSVVYL LQAWAQRGWR DTPRLWLVTT GVQVIASGEQ
     PGSPAAAPLV GLAAVITHEH PELRCAHVDL SAQPSPEEIA SLTEELLGDG AEDRIALRGA
     VRHVARLGRG ISGRKAAEPR EFTADGTYLI TGGLGGLGLE VAKWFIQRGA RNLALTGRGA
     PSEEAQKVLG ELRANGAEVR VYRADVTSAA DVARLLGSID SELPPLRGVV HAAGVIADGV
     LTQLDEPRLR AVLAPKVQGA WNLHVQTQGR PLELFVMFSS AASMMGSPGQ GNYAAANAFM
     DVLAHHRRAA GLPGLSVNWG PWADVGLAAV ATNRGDRLAL RGVGNMPPAQ ALEALGRLLV
     QEAAQVAVVP LDLRQWREFY LSAAQSPFLS VLMQEKVSTP ASRKGSAREL LAAAEPEQRK
     GILEGYLREQ LGRILRMEPS RIEPDQPFGD LGMDSLTGLE LRNRIESGLK LTLSATLIYA
     YPTVQALTTY LYGKLEPVLE AEARPTVRPT QTEPRVSVGV APASQGPELL AIVGMGCRFP
     GGANEPEAYW RLLSDGVDAV REVPADRWQS STDAAEHKGT RWGGFLDRVD GFDPEFFGIA
     PREAVAMDPQ QRLLLEVAWE ALENAGLPKS RLAGTRTGVF VGVCGYDYAM LQAERDVEGD
     VYSVIGCSNS VIAGRLSYLM DLRGPAMTVD TACSSSLVAL HLASQSLRNR ECDAALVGGV
     NLLLSQRPSS WLSKLMALSP DGRCRTFDSR ANGFVRGEGC GVVVIKRLSD ALASGDNVLG
     VIRASAVNQD GGSTGLTAPN VLSQQALIRD ALKSANLSPK EIGYIEAHGT GTPLGDPIEV
     EALRETYGVR RDDGFPCFLG SAKTNIGHLE AAAGMAGLIK VLLALRHEAI PKHLHFKALN
     PRITIEDTPF VIPTQMQPWP VSQRRRYAAV SSFGISGTNA HVILEEAPSP LPAPVAAEAG
     AQLLALSARS EGALRALARS YQELLAKPQD EALRLEDIAY TAALRRNPHE HRLSVAGRSK
     QELSEQLQSF LDGSTPPYLT TGLAESRREK VVFVFGGQGS QWQGMGRDLL ARSEPFAAAL
     RECDSLLAQH TGFSIIEALE VEGPTSRLDE TEVAQPAIFA IQVALAAAWR ALGVVPAAVV
     GHSVGEIAAA HVAGALSLAE AARLVAHRSR LMQRATGKGR MAAVELSSED AQRELARYSD
     RLSVGAINDA RSVVLSGEPS ALGEVLESLR ARGLSTRDLG VNYAFHSQQM ASLQPELIEA
     LGQLETRPTS IPMISTVSGQ VIEGQALDAA YWASNIREAV RFSDAVGALI DEGHRLFVEL
     GPQPALGRYV SQALERRELE GAAVPSLRKG RDGQTVMLGA LGGLHVKGFP VDWARLFPSG
     GRLVSLPLYP WQRSRYWIDL DDASATSQAP TTSARGVASG APASSTSRPD DWVYDITWQA
     RERGAASPRA QQGTGTWLIL GHREGTGAAL AALLEQRGEP CWLVVPGEEA EVLGPTLRSI
     HPQRSEHFER LLQEVGPIRA VVHLWGADAS PASEPKLAEV ESAQQLGVHA VVRLVQAFLK
     SGSASGARLW LCTRGSQAVG GAMGGSPLQA PLWGLGRVMA LEYPDAWGGL LDLDPSAPAG
     EVEALWKELS GFDGEDQAAF RDGVRYVARL VPAAPKPALA PVALRPDASY LVTGGLGGLG
     LHVARWLVSK GARHLVLLGR KGLPDRSEWP TIARESDVGR QIAAVEALEA NGAVVHALSA
     DVGNPIRMAE VIQSIQQGPA PLKGIIHAAG VSTLVSLDTM DEAALASILR PKVTGGWVLH
     QVTQGLDLDF TVYFSSGSAV WGSARMAHYA AGNQFLDSLA HYRRARGLHA LSINWGPWAA
     EGMVAEEGLR WFERMGLRGV SVEGGLHVLE ALLAMDVTQR SVAQIDWSLF KSVYESRTRK
     PLLEALGPAS VPVPRSVEVA AGNEELAQLR NASPARRKEL VIAWVREEVA RVLGFPSSAS
     VKLEQGFFET GMDSITAVEL RRRLVARFGV QLATTVAFDR PTVLALSTHI LQDVLRLDVE
     AKEEASRVVG NATEPIAIVG IGCRVPQASG PEAFWKLLEG GVDAIREVPA SRWKVEDYYD
     PQPGVPGKTY TRWGGFLDGA DQFDAQFFGI APREAANMDP QQRLLLEVAW ESLEHAGIAP
     ARLANTRTGV FIGIGSNEYA MLNGVGSASA AGDAYIATGN DSSFAAGRLA YLLRFQGPTM
     SLNTACSSSL VAVHLACQSL RAGESNLALA GGVNMTLAPH STIYLAQLRA LSQDGRCKTF
     DASADGYVRS EGCGIVVLKR LSDAKRDGDD VLAVIRGSAV NHDGPSSALT VPNGDAQQQV
     LRAALANAGV APADVDYIEA HGTGTSLGDP IEVQALANVL GQGRTSEQRL LIGSVKTTIG
     HLEAAAGIAG LIKVVLAHRH GVVPPHLHLK KLNPHIELNG FPLDIPTQVT PWPERARPRI
     AGISAFGLSG TNAHVLVEEA PAPEPRAEQA ERSLHVLALS AKTKGALTQL AARVGEYLAE
     QPEQKLADVC HAANTQRTWF SHRLALVVES VEQTRERLLA FARGEEVPRL AQNRVEGEDP
     KVVFVFTGQG AQYAGMGREL YETEPVFRAA LDRCNALIEG KWAESLLSVM HGTGSRIDDT
     EYTQPALFAL EYALAELWRS WGVEPWAVLG HSVGEYVAAC VAGVMELEEA LGLITERARL
     MQALPRNGEM VAVSASEAQV QEMLAPYADR VSIAAVNGPA DTVISGEREA VEAISASLQA
     KGVKARRLTV SHAFHSPLMD PMLDAFEKAA GKIAFRAPRL HLASNVTGQL LGDGAVLDAA
     YFRRHVREAV RFHDGLKALR ALGGTVFVEV GPHPTLTSMA LKGLGDDAGT WLPSLRKGQP
     EQPQILSSLG ALYTQGVAVN WIALNGERHR SPVALPVYPW QHQRHWLETA KTPRPVAPTT
     CAQSLVGQRV RSPLNKSIVF EGRYSAQSLP FLDDHRLYGT VVVPGSCHIA RIIATAAQSF
     GTGPYTIEKC LFSQPIVLAD DEEQLVQLVL APKGQGRYDF EIYSLSPTAD EETEGWLLNG
     TGTLQVGGDG HSRPEPISRQ DIEARCTRLM ESGLYEKNWD IGFNLGHAFR WIERVQSGGR
     EALCQMRLPT ERDDRGLYVH PGLVDSFLQA MGTDLIREDA QLSTVYVPIS VERFRFYEQP
     TGPVWAYAVR RDAEEAVGEV ITGDVYVVNA EGRVLIEIEG LKHKRAPREA LMAVLRHGQR
     DTLYELGWKR QPLPEGVPGS GRWIVFADET GTGEALAERL LKSGCRPVLV RPGEAFARQD
     GDRFTLDAQR AEDYARLLKE AVPSGESLGG VVHLWAMRGA HGNDVESLHA AHQLGGGSAL
     HLAKAVASFP SAARLWLVTR GARALPSHSG PLALNQVPVW GLGVVFSQEH PERCGALIDL
     DPSASGEDAT AIWRELSAAD GERQVVIREG QRHVARIRAS RDEQRNAAQR LRPDASYLLT
     GGLGGLGLSL ARWMVDQGAR NLVLIGRGAA KPEAQETLRT LEAAGAKVLV LQADVSKQAD
     VRRTLEEAEK LAPLRGVVHA AGVLDDGVLL QQDWERFSRV FAPKVDGAWH LHELTKDKEL
     DFFVLYSSAA TLLGPPGQGS YAAANAFLDA LAHHRRSQGL PALSINWGPW AEVGMAAQHA
     SRFQTQGIEA FSPEAALKAF SQALSRAQPQ LTLMQVQWSR YLAQYPRGAA PTVLAEVSGR
     AVAEPEANGH SASEFRRRLE SAEPRQRLPL LLEHVQGEAV RVLGLDASAS LEPRQRLFEV
     GMDSLMALEL RNRLQTTVGA SLPSTLVFDY PTAEAIANYL LGEALGLEKQ SAGNAQGEVQ
     DTALLERIME LSPDELAASL EAKLSALMEE GS
//