ID   Q96WT2_9ASCO            Unreviewed;       944 AA.
AC   Q96WT2;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   03-NOV-2009, entry version 25.
DE   SubName: Full=Aphidicolan-16beta-ol synthase;
GN   Name=ACS;
OS   Phoma betae.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; mitosporic Ascomycota; Phoma.
OX   NCBI_TaxID=137527;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Oikawa H., Toyomasu T., Toshima H., Ohashi S., Kawaide H., Kamiya Y.,
RA   Otsuka M., Shinoda S., Mitsuhashi W., Sassa T.;
RT   "Cloning and functional expression of cDNA encoding aphidicolan-
RT   16beta-ol syntase: A key enzyme responsible for formation of an
RT   unusual diterpene skelton in biosynthesis of aphidicolin.";
RL   J. Am. Chem. Soc. 2001:5154-5155(2001).
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DR   EMBL; AB049075; BAB62102.1; -; mRNA.
DR   InterPro; IPR017057; Ent-kaurene_synthase_fun.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PIRSF; PIRSF036498; Ent-kaurene_synthase_fungi; 1.
PE   2: Evidence at transcript level;
SQ   SEQUENCE   944 AA;  106581 MW;  41C781606F236CE5 CRC64;
     MVPISTRSEV QDGLIAQARS LITRIVHNSD DVYGFGTLSC TVYDTAWVAL VTKHVNGIKH
     WLFPESFHYI LASQCDDGTW CEDKTAQFDG VLNTIAGLLV LKRYRRDPLQ LKVDNRDLDS
     RIKLATSALH SLLEEWDVST TNNVGFEIIV PTMLDLLVQE DPSLSFELKG REALTEIREA
     KMNRFQPELL YQGKLMTLTH SLEALLGRID YDNVARYTVK GSMFASPSST AAYLMSASTW
     DDEAETYLRY TITASTGKGS GGVPGVFPTT YFEYTWILST LFRAGFQSSE LDSPELTAMT
     DTLLKAFKAF SGAIGLDSGI EPDVDDSAKI VTTLNMLGKP AHARYLCDNF EVETHFRVYP
     RERDPSFSAN CNALAAFLHQ PDVEVYSSQI LKAASYLCER MWNADEKIDD KWNKSHLYSS
     FLYTQVMTDL MAITEAGRLD GVFTRELLTR VCVTIFQSCL RAMLKQSHDG SWNQSLEETA
     YAILHLTEAR RLCFFEQISE PLENSIYRGI TFLTTIDKPP MEYLWSDKVS YGSAYLAETY
     VLAARRAAES TSVTNLVGSS IWKDNASTKM HKLVGLFHRT PLLKALPKWE LQASMIEASI
     YQGLLQDARL EVLQRPKVDG GEYLSIIPFT WTSCSNSART NASASHLWEL MALSFFTYQV
     DEFMEAVAGP AFKGRMTHLH AIIDEAVHCS QNRERTPGEC ENTNHVTSEL LQAVRFILDN
     PTVRKASPYD RNTLLQELRI FLHAHVTQVE DNASFGRERL TGDKALTSYR SQLYRWVHTI
     SSDHIAGPFC FYYATCLLGA TLTAHPPNDC FPKSSQKYLA AATCRHLSCM CRMYNDIGSW
     NRDHREGNLN CLHFPEFSET TSDDAERKAS LLTLAQYERK QWCNALQQLE KEMVHGASEP
     AAARLAKRRA CLIDMFCKVT DLYGQIYVLR DVSSVIKDVV RNGE
//