ID Q9EWA1_9ACTO Unreviewed; 9507 AA.
AC Q9EWA1;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 19-JAN-2010, entry version 53.
DE SubName: Full=PimS2 protein;
GN Name=pimS2;
OS Streptomyces natalensis.
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Streptomycineae; Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68242;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=20547809; PubMed=11094342; DOI=10.1016/S1074-5521(00)00038-7;
RA Aparicio J.F., Fouces R., Mendes M.V., Olivera N., Martin J.F.;
RT "A complex multienzyme system encoded by five polyketide synthase
RT genes is involved in the biosynthesis of the 26-membered polyene
RT macrolide pimaricin in Streptomyces natalensis.";
RL Chem. Biol. 7:895-905(2000).
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DR EMBL; AJ278573; CAC20921.1; -; Genomic_DNA.
DR HSSP; P25715; 1MLA.
DR GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR InterPro; IPR001227; Ac_transferase_dom.
DR InterPro; IPR009081; Acyl_carrier_prot-like.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPlipase.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR006163; Phsphopanteth_bd.
DR InterPro; IPR020842; PKS/FAS_KR.
DR InterPro; IPR020801; PKS_acyl_transferase.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_reg.
DR InterPro; IPR020807; PKS_dehydratase.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR006162; PPantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR016038; Thiolase-like_subgr.
DR Gene3D; G3DSA:3.40.366.10; Ac_transferase_reg; 6.
DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 6.
DR Gene3D; G3DSA:3.40.47.10; Thiolase-like_subgr; 12.
DR PANTHER; PTHR11712; Ketoacyl_synth; 1.
DR Pfam; PF00698; Acyl_transf_1; 6.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF00109; ketoacyl-synt; 6.
DR Pfam; PF02801; Ketoacyl-synt_C; 6.
DR Pfam; PF08659; KR; 6.
DR Pfam; PF00550; PP-binding; 6.
DR SMART; SM00827; PKS_AT; 6.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 6.
DR SMART; SM00825; PKS_KS; 6.
DR SMART; SM00823; PKS_PP; 6.
DR PROSITE; PS50075; ACP_DOMAIN; 6.
DR PROSITE; PS00606; B_KETOACYL_SYNTHASE; 6.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 6.
PE 4: Predicted;
KW Phosphopantetheine; Transferase.
SQ SEQUENCE 9507 AA; 994260 MW; 57BD80C8AD37E89F CRC64;
MDQEQKLRDY LKRASADLRR SRQRVGELEA AAREPIAIVG MSCRFPGGVR SPEELWSLLA
ADGDGITKSP ADRGWELLAE DAGEFSGGFL HDAAEFDASF FGISPREALA MDPQQRLLLE
SSWEAFERAG IDPAAVRGTR TGMFVGAMPQ EYRVGPDDDV QGFALTGTTT SVISGRLAYF
FGAVGPAVTV DTACSSSLVA LHLAAHSLRQ GECSLALAAG VTVMSSPTTF VEFNRQGGLS
ADGRCRSFAD SADGTGWSEG VGVLVLERLS EARRNGHEIL AVIRGSAVNQ DGASNGLTAP
NGPSQRRVIE QALVSARLSA DEVDVVEAHG TGTTLGDPVE AQALLATYGQ GRDDDRPLLL
GSVKSNLGHT QAAAGMAGVI KMVLAMRHGV LPRTLHVDAP SSHVDWTQGA VRLLTEHVPW
PQGEQPRRAG VSSFGLSGTN AHTILEEAPA APSPEAGQED TAPVAEPLAA GAVPWLVSGR
TREALRAQAA RLLEHLTSRP GLAPLDVAYS LATARSGLEH RAAFTAAGPD GARAALTALA
DGTPAPGLVQ DTARTRSKLA FLFAGQGSQR PGMGRELAAR FPVFATALDE VLGHFDEGLE
RPLKDVLFAA EGTPEAALLD QTGYAQPALF AIEVALYRLA ESFGITPDFL AGHSIGEIAA
AHVAGVFTLA DAAALVLARG RLMQALPEGG AMVSLEATEE EVLPLLEDRP DRLSIAAVNG
PAAVVIAGEA DDVTAVAEHF DALGRRTKRL RVSHAFHSPL MEPMLAEFRT AVSRLTPQAP
VIPVVSGLTG TLATVEQLTS PDYWLDHARH AVRFADALRL ARRARRRHLP RMGPDGVLSA
MAQSCCRGHG HRRRRRLRHA RRVRPGRPEA ETLTAALAGL HTRGVAVQWE PYFQGTGARR
ADLPTYAFQR RRYWPKSLPA TGGDVRAAGL GAAHHPLLTA AVSVANSDGL LLTGRLSRRT
HPWLADHAVR GTVLLPGTAF LELAVRAGDE AGCGRVEELT LAAPLVLPEE GGVQVQVWVG
SPDASGRRAV SVHSRPDGPE ELPWTQHAAG TLVAGEHHAG FDATVWPPAD ATPLDLDGFY
ARMADTGFGY GPLFQGLRAA WRSGDDVYAE VALPDSDGAA STESSAAFGL HPALLDAALH
AAAFVDLGED ARGGLPFSWQ DVTLHASGAS TVRVKLTPDG DDAVALAVAD TTGAPVASIG
SLVLRTLPDE QIDAAHSLVR DALFELRWSE ARQTAHEAPA SAAVLGPDLF GLERALAPTD
LTVTAVPGPD AAPHAPDVVL APVAGTTEDD VVTSVHARTA HVLERLRTWL TDERYAASRL
VFVTRGALAT DARQASDPVA AAVWGLVRAA QSEHPGRFGL LDLDPGTTEP ATEPLLRALA
LSSDEPQTAV RGTAVLTARL ARAQAPQAAT EWDPEGTVVL TGATGGLGRV LARHLVAERG
VRHLLLVSRR GADADGAGEL MAELAAHGAQ VTLAACDLAD RAAVRRLLSG VPAEHPVTAV
VHSAGSLDDG VIASLTPERI SAVLRPKADA VWHLHEATRD LDLAAFVVFS SLSGTVGAAG
QGNYAAANAF LDALAQLRRA QGLPGLSLAW GPWAPTAGMT GGLTDDDLDR LARMGTPALT
EEQGIALFDA ATATDAAVLL PTRIDLSVLR VQSEIPPLWR GLIRTPARRS VVSASETAVT
LVQQLSRLAE TDRREVVLDL VAGQVAAVLG HAGTADIDPR RPLRELGFDS LTAVELRNRL
SAATGLRTAA TVIFDHPTVD ALAAHLLDGL MGSEAAAAAD APRTAADDDP IVIVGMSCRY
PGGVASPEDL WRLVSEGTDA ISGLPTDRGW DLDALYDPDP DRTGTSYSRF GGFLHTAADF
DPAFFGMSPR EALATDSQQR LLLEASCEAV ERAGIDPVSL RGSQTGVFAG VMYNDYATVL
SGGQFEGHQG SGTAPSVASG RISYTLGLEG PAVTVDTACS SSLVAMHWAM QALRAGECSL
ALAGGVTVMS TPGALIEFSR QRGLSPDGRC KAFSDGADGV GWSEGVGVLV LERLSDARRN
GHRVLAVVRG SAVNQDGASN GLTAPNGPAQ QRVIRQALSA AGLSATDIDA VEGHGTGTTL
GDPIEAQALL AAYGQDREAG SPLLLGSVKS NIGHTQAAAG VAGVIKMVMA MRHGVLPRTL
HADEPSSHVE WDSGAVRLLT EETPWPQADR PRRAAVSSFG FSGTNAHLIV EEPAAVAERR
EEPALTPAVV PWTLSGKSRA ALRDQAARLR SFLEERPALD PADVALSLAT TRSAFDQRAV
VTGDRDELLR ALADLAADRP GPALTEGEVG GAGKLAVVFS GQGSQRPGAG RELAARFPVF
AQALDEVTAA LDPHLDRPLK DILFAPEGSP EAALLDRTEW TQPALFAIGV ALHRLLGTWG
IRPDVLLGHS IGEITAAHVA GVLSLPDAAR LVIARGRLMQ ALPAGGAMIS LEATEDETAP
LLAGRDHEVS LAAVNGPRSV VVAGELAAAE EIAAHFADRG RKTKRLTVSH AFHSPLMEPA
LDGLREAAAE LTYHAPDVTV ISGLTGRPAT EAELRSADYW VAHARGAVRF ADTLRAAHDC
GAGTFLELGP DSVLSAAAQD ALGDDAEAHI VPLLRHGRGE ERCAATALAR LHVRGTTADW
PGYLAGTGAR TIDLPTYAFQ HERYWPEQAP ARLAQGAADP ADAELWGAVE RGDATELAAL
LGLRDEQHAS LYALLPALSS WRQHRQEKAL LDSTRYRVAW RPVQATAAPV LDGTWLLVTA
DGIDSDEILD ALRGHGAQFE TLVLDDACRD RAHLAGRLAA VRDQDRPLTG VLSLLPLADR
SGAEAGAEAG AETGAQPSTG LALSLVLIQA LADTGLAAPL WTLTRGAVTT GADDPLTHPL
QAAVWGLGRV AALEHPQLWS GLIDLPAALD APATQHLVSA LAAEGGEDQI AVRATGAFGR
RLVRHPQAEL PPADAFTARG TVLITGGTGA LGAEAARWLA RSGAEHLLLT SRRGPEAPGA
AELAAEIEEL GARVTLAACD TADRAALAAL LDSLPDEHPL TGVVHAAGVG QAAALADTPL
ADAAQAMAAK LLGAAHLDSL LDGHDLDFFV LVSSIAGVWG SAGQSAYSAA NAYLDALAEH
RAARGLPATS VAWGPWAEAG MATHEAVTDE LHKRGLRFLA PATALAELRR AVVHRDVTVT
VADIDWERYH PVFTSTRPSA LFDELAEVQA LIRPEDESAA PEFAARLRGL DQDGQERLLG
DLVRAEAAIA LGHDSADAIA ERRAFRDAGF DSLTAVELRK RLAALTGLAL PATLVFDYPT
PVALARHLRE QLLGTAQESA APVAVPSGGF DEPIAIVGMS CRFPGGVRSP RQLWDLVSEG
VDAISDFPVN RGWNTGLFHP DPDNPGTTYS TQGGFLHDAG EFDASFFGIS PREALSMDPQ
QRLLLETTWE AFEHAGIDPT TVHGTTTGTF IGSTYQEYGL GVEDGSAGHL VTGTSPSVLS
GRLAYLFGLE GPAVTVDTAC SSSLVALHLA CQSLRNGESS LALAGGATVM TNPNPFVAFS
RQRALAGDGR CKAFSEGADG MTLAEGVGVL VLERLSDAQR NGHEILAVVR GSAINQDGAS
NGLSAPNGPS QQRVIRQALA NSGLTPADID AVEAHGTGTA LGDPIEAQAL LATYGPGRDP
DSPLLLGSVK SNIGHTQSAA GVAGVIKMVL ALRNGQLPRT LHADTPSSHI DWTPGTVSLL
TEPTDWPEGE RPRRCAVSSF GISGTNAHTL LEEAPRPHEA TPAGPVPPAG DAIPWVLSAR
TPGALRAQAA QLAAHLDGEA PDALDVGHTL VAARTLFDHR AVVVGTDDAS RRAALDALAT
GGSAPGIVQG TADTDGRTVF VFPGQGSQWA GMGARLLEES PVFAARLTEC ATALSEFVDW
SLLDVLRQAD GAPTLDRVDV VQPASFAVMV SLAALWTSHG ITPDAVVGHS QGEIAAAAVA
GALSLEDAAR VVALRSQAIA RGLAGTGGML SVPLPAADVE QRLAAYEDLS IAAVNGPRST
VVSGATAPLD ALQAELVGED IRARRIAVDY ASHSAQVERV RDELRTVLEP VRPRPAQVPF
FSTVTGDWLD TTVMDAEYWF TNLRRTVHFQ PAIGELLAQG HHFFIEVSSH PVLSMGIQAT
AEEAGAAAAV LGTLRRDTGA TDRFLASLAE AFVRGADADW SAVFAGTGAR RVPLPTYAFQ
REHLWAIPER SPDRPEADPA DAEFWTAVEE EDVEALASRL RLDRTSLAPV LPALSHWRKR
RRELSTVDSW RYRATWKPLT GLPAAALTGT WLVVAPEGAD TDTLTGVLAA HGAGTRTLVL
DDSCADRATL TARLTGLDGA ADLTGVVSLP APADEASATH PTLSRAVTLT VALVQALGDA
GIDAPLWCLT QGAVSTGRAD RLTRPDQAQI LGLGWTAALE HPQRCGAGLV DLPEELDRRA
GERLAAVLTG RSGEDQLAVR SSGVFARRVV RAAPADPAPA RPWTPRGTTL VTGGTGTLAP
HLARWLAQQG AEHIVLTSRR GPAAPGAAEL VQELAELGCQ AEAVACDLTD RDAVAQMLAA
LRAEGRTVRT VVHTAVTIEL APLDETTLDD FAKVMDAKVI GARHLDELLG DDLDAFVLYS
STAGMWGSGA HAAYVAGNAY LNALAEHRRA RGARATAVSW GIWADDLKLG RVDPGQIRRS
GLVFMDPQLA LTGLRQALDD EETHLAVADV DWGRYYPVFT AARPTRLFED LPEVRQLAQE
SAEVTDSGSE FATRLDGLAA VEQDRLLLDL VRTEAATALG HASPDVLSEQ RAFRDVGFDS
LTAVDLRNRI ASVTGLALPS TMVFDYPNPL ALVAFLRESL AGSATGTAAT TTHTAAADEP
IAIIGMSCRY PGGVGSPEDL WRLVTEGGDA TGEFPADRGW DAEGLYDPDP DRAGHTYSTR
GGFLHDAADF DASFFGISPR EALAMDPQQR LLLETSWEAM ERAGIDPATL RGSSTGTFIG
ASYQDYRAFG AGPDGAEGHL ITGTISSVLS GRLSYTYGFE GPAVSLDTAC SSSLVALHLA
CQSLRNGESS LALAGGVSIM STPGAFVGFS RQRAMAADGR CKAYSDQADG MSLAEGVGLV
LVERLSDARR NGHQVLAVIR GSAVNQDGAS NGLTAPNGPS QQRVIRQALA NAEVDPDGID
VIDGHGTGTA LGDPIEAQAL LATYGQGRDP EHPLLLGSVK SNIGHTQMAS GVASVIKMVM
AMRHAAVPRS LHIDRPSSHV DWSSGAIQLL TEPLPWPATG HPRRAGVSSF GLSGTNVHTI
LEQAPEDRTE EDTDTAPARP ADPTPVPVTL SGRTEAGLRA QAGRLLTHLA DHPELPLTDL
AFSLATSRAA LEHRAAVVTD DPDTLTRALT ALRDATPDGG LLTGRPDRGR LAFLFTGQGS
QRPGMGRELY DRHPVYAEAL DAVLARFDLE LDRPLREILF ADPGTPEAEL LDDTGYTQPA
LFALEVALFR LAESWGLRPD YVAGHSIGEL AAAHAAGVLS LEDACTLVAA RGRLMAALPS
GGAMASVEAT EDEAAAVLAP YEGRAAVAAV NTPTSLVVSG DEDAVHAVAA HFHELGRRTK
QLRVSHAFHS PHMDAMLDDF TRAAEGITFH APELPLVSTL TGELILADDL CSAPYWTRQV
RGTVRFADAV RHLTEHGVTT FFELGPDAVL SGAVRESTGE QTPATAVPAL RRDRPEAPAL
TTALARLHLH GVRVDWDAVF AGGGARRIDL PTYPFQRERY WPEAAAGAAA PAHPADAADA
EFWSAVERAD LPSLGSSLDL DDDTLTAVVP ALSSWRRKSR ERSTVDGWRY RTTWKPLTGT
ATAGHPAGTW LVLAPADGDR AWTDAVAGAL GADAVRVEVS TAQRQELAER LSELAAEHGE
FAGVLSLLAT AGEGAEDADD ATTEGLLLTA TALQALGDAG IDAPLWCVTR TAVAVDRAEH
PARPAQAAVW GLGRVAALEH PQRWGGLVDL PDELDGATLR RLAAVLADSG DEDQLAVRTT
ATFVRRLAHH RAAPAPEAAT FRPTGTVLVT GGTGALGGHV ARWLAEAGAE HLLLVSRRGT
DAPGAGELAA EIAELGARVT VAACDTADRD ALAAVLAAIP DEHPLTAVFH TAGTVDDGTL
DTLTPEQFAS VLRTKVTATR NLHETTREQD LSAFVLFSSV AGTLGAPGQG NYAAGNAFLD
AFAAHRRAHG LPATSLAWGP WAETGMAADG TGIQDRVRRG GFTPMPPRLA LTALRRAIEH
DATALTLADI DWQRYAEVFT ATRPSLFVAD LPELQQVTPP AGTPEAALRE PALRQRLAGL
SPAARPRFVL DLVRTQVAAV LGHSGTSAIG AERAFSDLGF DSLTTVELRN TLTATTGLKL
PATLVYDYPT PTALADFLLA ELLGALPESG APAFVGRAAD DDPIVIVGMN CRFPGGIRSP
EDLWQLLSSG EDAISGFPAD RGWDLDALAR GASATLEGGF LDGVGLFDAP FFGISPREAL
AMDPQQRLLL ETSWEAFERA GIDATTLRGS RTGVFVGTNG QDYATLLRQG TGTTDIRGHV
ATGNTASVMS GRLSYAFGLE GPAVTVDTAC SSALVALHMA AGALRSGECT LALAGGVSVM
SSPDSFTEFT VQGGLAPDGR CKPFADAADG TSWSEGVGVL LLERLSDARR NGHDVWGIVR
GTAVNQDGAS NGLTAPSGRA QQRAIRQALA DADLAPADVD VVEAHGTGTT LGDPIEAHAL
IAAYGQDRPT DRPLLLGAVK SNLGHTQAAA GVAGTIKVLL AMRHGVLPKT LHTDSPSAHV
DWTAGTVSLL TEQQEWPETG HARRAGVSAF GVSGTNAHVI IEQAPDAEES VAPEPTTVPG
LVPWPVSGKS EAALEAGIER VSALTGRSPV DVGHSLTTGR AAFTHRAVLA ADGAGVRELA
RGVAHEADGK LAVLFSGQGA QRVGMGRELY VRFPVFAEAL DGVLAHFDAG LRDVMFGDAE
GLDETGFTQP ALFAIEVALF RLAESLGVRP DFVGGHSIGE IAAAHVAGVF SLADACALVA
ARARLMQALP AGGAMVAVQA TAEEAAARLV DGVSIAAVNG PEAVVIAGEQ REVLRIAKEF
TGLGRKTRRL PVSHAFHSPL MEPMLEDFRR VAEGLSYEAP RIALVSNLTG ELATEDLVRS
AEYWVRHVRE TVRFADGVSA LAAEGASVFL ELGPDGVLTA MAQHTLDGTA TAVPALRKDW
SEETALLTAL AQLHVVGVGV DWSGIFAGTG ARRVDLPTYP FQHQWYWPDG APAAEATTGA
QDPVDAEFWD AVERADLSSL SDSLELDDAA LSALVPALSA WRRKRVERST VDGWRYHVTF
KPLTGTAPGT LAGTWLALVP TGAADDEWTT AVLAALGDAV VIAEVDPADR GAFAGRLGEL
AERGTEFTGV VSSSQSRTPS PSPSDRPGPT RRWRALAEAG IDAPLWCVTR DAVPVDRSES
EVSPAQAAVW GLGRVAALDH PDRWGGLVDV PQEHDRRTAE RLRAVLSGAG DEDQVALRPS
GAFGRRLVRA TDDTPATPWQ PAGTVLVVGP ASGTGGHCAR WLAGQGAQHL VLADRTAPDT
AQLIGELDAL GVPLTVLDCA PADGEALLSA LAALPEPLTA VIYADGPSDA DAYGTATTAD
PGASLAALYA DVESLAAVAE AATGARPLGA FVLFSSIAGT WGAGGRGTEA AAGAQLDALA
GMLRARGLPA TAVSWGGWAD ATSGSLAAHL RANGLPPMDP ARALTALARS LGTDTPSVTV
ADVRWDEFAP AFTRRRHSAL FAELPEAREA LAESDGSAPG TADAASGLRA ELAARPDAER
TEHLLALVRD RVAAVLGFAD ADAVPSGQAF TDLGFDSLTA VDLRNQLAVA TGLALPATLV
FDYPTADALA GYLRAELLGE GGKDAEELPA VVRTKDADTA EDPVVIVGMS CRYPGGIRSP
EDLWQLVMGE ADAIGGFPTD RGWDLDRLLH GDRDGRGRTV TGQGGFLYDV ADFDPGFFGI
APREAMVMDP QQRILLEATW EALERTGIDP ARLRGGDTGV FIGGGSGDYR PEAGQLGHAQ
TAQSASLLSG RVAYHFGLEG PSVSVDTACS SSLVALHLAA QALRNGECSI ALTGGVTVMS
SPVNFVEFGE MGALAPDGRC RPFASAAGGT GWSEGVGVLV LERLSDARRN GHEVLAVLRG
SAVNQDGASN GITAPNGPSQ RRVIQRALAN AGLAPADVDA VEAHGTGTTL GDPIEAQALL
ATYGQGRDPE LPLLLGSVKS NIGHTQAAAG IAGVIKMVLA MRHGMLPRSL HIDEPSAHVD
WSAGAVELLA QAADWPRTGR PRRAGISAFG ASGTNSHVII EQPAPTVAEE PERPQEAGGP
LPVPVSGAVP DALRAQARQL HAYVAGRPGL TVAEFALSTA TTRSAFTHRA AVLAEDREEL
LAGLAALAGG LDTPQVLRGR VAERRGRLAV LFSGQGSQRV GMGRELHARF PVFAEALDEV
TARLEAELEL PLREVMFGDS ERLNETGYTQ PALFAIEVAL FRLVASWGIR PDFVAGHSIG
EIAAAHVAGV FSLDDACRLV AARARLMNAL PAGGAMVAVQ ATEEETRACL TDGVSIAAVN
GPRSVVLSGD EAAVLDLAEK FTADGRKTRR LRVSHAFHSL HMDAVLDDFR RVAQSVGYDA
PTIPLVSNVT GEAATERQVC SPDYWVRHVR EAVRFGDGVR TLADRGVTAF LELGPDGALC
AMAQETLDTL PSPAVTVPAL RRDRGEQECV VTALARLHVD GVSPHWPAVL TGPRTAPRRT
DLPTYPFQHQ RFWPAAQPAT DPTPATAADD GFWSAVREAD FADLATTLDV ERDALSTVLP
ALADWRRRRE ESGTVDGWRQ QITFEPLTRT PSHTPAGTRL AVIPAGHEQD PLVADVVAAL
GPDTVRLTAP GSDRAALADL LRQQAADGTE FTAVVSLLAL ATEPAHSEPA HSEPAHPAHA
PEALALTTTL IQALGDADLA APLWCVTRGA VAAAPGEPVS GPAQAAVWGL GRVAALEYPQ
RWGGLIDLPA ALDDRTAARL ADVLAAPGGE DQIAIRPSAV LGRRLVPVPA GRTTREWNPT
GTVLITGGTG ALGARVAREL ARAGAEHLLL LSRRGPDAPG ADALRAELTA LGADVTLTAC
DAADRDALAK VLADIPETSP LTGVVHTAGV IDDGVLDSLT PDRFEDVFRA KAASALALHD
LTEDLDLAVF ALFSSSSGAV GNAGQANYAA ANAFLDALAE RRRAQGLAAT SLAWGVWGGG
GMAADQRAAD VARRTGIRPL DPDLAVVALR RAVMDGRPTE VVADIERDLF VRSFTAVRPS
PLLGAPTVDA EHRAAGDTGE DTTGDALRAK LTGLPPAKRS EAVRDLVRTR AAAVLGHPTA
DAVGADRAFR DLGFDSLSAV ELRNQLGAAT GLNLTATLVF DHPNPAALAD HLLSLLVPDE
DPGEGTADDG DPDSSAIRAL LASVSVAQLR EIGVLEPLLK LAAEQTAASG AEAAAATAAD
AYDESIDAMD IADLVQAAFD GNSPQER
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