ID   Q9EWA3_9ACTO            Unreviewed;      2024 AA.
AC   Q9EWA3;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   19-JAN-2010, entry version 55.
DE   SubName: Full=PimS4 protein;
GN   Name=pimS4;
OS   Streptomyces natalensis.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=68242;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=20547809; PubMed=11094342; DOI=10.1016/S1074-5521(00)00038-7;
RA   Aparicio J.F., Fouces R., Mendes M.V., Olivera N., Martin J.F.;
RT   "A complex multienzyme system encoded by five polyketide synthase
RT   genes is involved in the biosynthesis of the 26-membered polyene
RT   macrolide pimaricin in Streptomyces natalensis.";
RL   Chem. Biol. 7:895-905(2000).
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DR   EMBL; AJ278573; CAC20919.1; -; Genomic_DNA.
DR   HSSP; Q53908; 1LQ9.
DR   SMR; Q9EWA3; 1249-1595, 1367-1725, 1720-1751.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   InterPro; IPR001227; Ac_transferase_dom.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPlipase.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR006163; Phsphopanteth_bd.
DR   InterPro; IPR020842; PKS/FAS_KR.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_reg.
DR   InterPro; IPR020807; PKS_dehydratase.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR006162; PPantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   Gene3D; G3DSA:3.40.366.10; Ac_transferase_reg; 1.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:3.40.47.10; Thiolase-like_subgr; 2.
DR   PANTHER; PTHR11712; Ketoacyl_synth; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SMART; SM00824; PKS_TE; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 1.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine; Transferase.
SQ   SEQUENCE   2024 AA;  212175 MW;  7751312CBE95C228 CRC64;
     MPNDKPNDKK LVDYLKWVTN DLHQTRQRLR EVESAKQEPI AIVGMSCRLP GGVRSPEEFW
     QLLKDGRDGI STFPTDRGWD LDLLAGDGSG SSATAEGGFI DAASFDAGFF GISPREAVTM
     DPQQRILLES SWEALERAGI DPVSLRGTET GVFVGTSGID YINTVMNSRE DIEGHGSTGL
     IASILSGRVS YTFGLEGPAV TVDTACSSSL VSLHLAAQAL RVGECSLALA GGVTAISTPM
     SFVGFSRQGG LAPDGRCKAF SDTADGTAWS EGVGVLVVER LSDARRNGHP VLAVVRGSAV
     NQDGASNGLT APSGPSQQRV IRQALAAAGL SASDVDVVEA HGTGTALGDP IEAQALLATY
     GRDRDPERPL LLGSVKSNLG HTQAAAGAAG LIKMILAMRH GVLPRTLHVE APSSHVDWSS
     GALQLLTEPQ EWPKADRPWR AGVSSFAISG TNAHIILEQP PAAEEPEDEE GPHTSPSAVP
     WLVSAKSEEA LTAQLDRISA LTDRSPLDLG LSLATTRAHL EHRAVLLSEG GETVEVARGH
     AEHTAGKLAV LFSGQGAQRV GMGRELYGRF PVFAEALDGV LAHFDAGLRD VMFGEAEGLD
     ETGFTQPALF AIEVALFRLS ESLGVRPDFV AGHSIGEIAA AHVAGVFSLA DACALVAARA
     RLMQALPAGG AMVAVQAAES EVAARLVDGV SIAAVNGPEA VVIAGEEREV LRIAEEFTGL
     GRKTRRLPVS HAFHSPLMEP MLEDFRRVAE GLSYEAPRIA LVSNLTGELA TEDLVRSAEY
     WVRHVRETVR FADGVSALAA EGASVFLELG PDGVLTAMAQ HTLDGTATTV PALRKDRSEE
     TALLTALAQL HVAGVGVDWS GIFAGTGARR VDLPTYPFQH ERYWPRPAVL SGDVVGAGLR
     SAEHPLLGAT LTLAESGEVV LTGRLSLQAY PWLTDHTMGG SVLFPATGFL ELAMRAADQV
     GCDRVDEFVL MTPLVLAEES GTQVQVLVGP ADEAGTRTIS IHARPDGDPD QPWMQHAGGT
     LTSGERIVDF GSTVWPPQGA EAVDLEGFYD TTGYGPAFQG LRSVWQCEDG AYVEVALPDQ
     VAEDAGAFGL HPVLLDAVLQ SRRMAGIGAA GDTFLPFAWR GVSLHAGGAS VLRARVIKTG
     EDTLSLVAVD AEGAPVLSVE ELVLRTQLTH TDAPLTARRG AERDALLSLE WVSGPEVPPA
     GVRCVSLGAD ELGVGASVAT LADLSGDEDF VVVPVSGVGG DVPAAAHELT ARTLGLLQEW
     SGREGTSASR LVFVTRNAVS ADGGESVRDV AAAAVWGLVR SAQSESPGRI ALVDLEADSG
     DLAEVLAGLP GLLAAGDAQF VVREGAVRVG RLVESNEGAG VSPREWDADG TVLVTGGTGG
     LGRELARHLV VERGVRHLLL VSRSGPEASG VGELRDELAA HGAEIAVRAC DVADRAAVEA
     VVGAVDAAHP LTAVIHTAGV LDDGVIASLT PERLSAVLRP KVDAAWNLHE ATKDLDLAAF
     VLYSSISGVL GSLGQGNYAA GNVFLDALAG HRAGLGLPAQ SLAWGAWTQG GGMTATLSDA
     DMQRMASYGT APLSPERGLA LFDAATAGSA THLVAVGRVS GPVRAQGPVP SMLRGLVKGA
     RRTAVNTTGE TAVSLADRLR AARPEERTQL MTDVVRTEAA AVLGHASSQN VDARREFYEL
     GFDSLTSVEL RNRLSTVTGL RLSATVVFDS KNPTDLAARL YADLAAQSAL DGSASQAGFL
     PVAAPETDSL ERMFLDALDS GKVPEAQRML SALGALRPSF ENTAELEDLP LPATLAEGPG
     TPRLICVSTP TANGGVHEYA RLAASFRGER HVSALPLVGF ATGERLPATA ETAVRVIAES
     ALRASDGNPF VLVGHSSAGA FAYLAAALLE NTWGIRPEAV VLLDTLSLRH EQNESIDYAG
     LMRRHFMVDE VSPVRMTNSR LSAMARWMGM LNQLEVRHTT VPVLIIRATK ETFGIGTDTG
     IYGEDHGSPV DVRSVDADHF SMVRDDAPET ARIVREWLDS LGNA
//