ID   Q9FB18_9ACTO            Unreviewed;      2626 AA.
AC   Q9FB18;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   19-JAN-2010, entry version 44.
DE   SubName: Full=Peptide synthetase NRPS2-1;
GN   Name=blmIV;
OS   Streptomyces verticillus.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=29309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC15003;
RX   MEDLINE=20389599; PubMed=10930733;
RX   DOI=10.1111/j.1574-6968.2000.tb09225.x;
RA   Du L., Chen M., Sanchez C., Shen B.;
RT   "An oxidation domain in the BlmIII non-ribosomal peptide synthetase
RT   probably catalyzing thiazole formation in the biosynthesis of the
RT   anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003.";
RL   FEMS Microbiol. Lett. 189:171-175(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC15003;
RX   MEDLINE=20500448; PubMed=11048953; DOI=10.1016/S1074-5521(00)00011-9;
RA   Du L., Sanchez C., Chen M., Edwards D.J., Shen B.;
RT   "The biosynthetic gene cluster for the antitumor drug bleomycin from
RT   Streptomyces verticillus ATCC15003 supporting functional interactions
RT   between nonribosomal peptide synthetases and a polyketide synthase.";
RL   Chem. Biol. 7:623-642(2000).
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DR   EMBL; AF210249; AAG02364.1; -; Genomic_DNA.
DR   HSSP; P14687; 1AMU.
DR   SMR; Q9FB18; 17-444, 958-1004, 1511-2016, 2041-2559.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR013624; NRPS.
DR   InterPro; IPR006163; Phsphopanteth_bd.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF00668; Condensation; 3.
DR   Pfam; PF08415; NRPS; 2.
DR   Pfam; PF00550; PP-binding; 1.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 2.
DR   PROSITE; PS50075; ACP_DOMAIN; 2.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
SQ   SEQUENCE   2626 AA;  284285 MW;  6579B49BEEE0299D CRC64;
     MLHGAAHPRP GIPRRGATAA PASYGQERLW LLTGLLPTAY NYATALRLRG DLSVPALRGA
     LRGIVRRHEV LRTTFRLDGD DLIQVVHPTA DVPVRLADLT GRSADTGRLM REEARRPFDL
     EHGPLLRLTL FRLGPRDHLA LLAVHHAVTD GWSNGVLVTE LATGYRELRA GRPDRRPAPP
     VQYGDYAHWQ RERLTGPELR ALEDYWRTAV RDLPRTDLPT DRPRPAARRG EGANHALLLS
     PELTGRLADL RRREGGSLFM LVLSALLVVL RGTGGRDRLA VGTLVAGRTR PELEPLIGYF
     VNVLLLPFET GGRTSFAELW RRVRGRLVEA YAHQELPLEK ALELLRADGT APADPPVGVV
     CVAQQPAPAI TLPGLDASVE DVDLGTAQFD LVVEVRERPE GVQIAFQYDR DLFDAATVRL
     LADHVHAVLD QAAADPTLPC AELPAPPAPA APARTAGATT LHALFESRAA KSPDAVALVD
     GGHRVTYRTL NTRANRLARH LRAVGVRTED RVALRLPRGT DAVTATLAAL KAGAAYVPLD
     PALPEERLTR VLADARPAVV LTPAYLHDRS AEITAHAGHD LNLPVHPDNL AYLLHTSGST
     GTPKGVLGTH RGAVNRVDWM STAYPFRTGD VAVARTAPGF VDAVWELFGP LAAGVPLVLL
     PTDEARDPAL LTAALERHRV SRMVTVPSLL TMLLDESARA TDLGTRLACL RTWITSGEPL
     PPALARRFHD RLPGRTLLNL YGSSETAADA TAARIDPAPG TALPERSPIG TPITGVSALV
     RGPDLRPLPA LMPGELYAGG ACVARGYHAR PAETAAAFPP DPDGGPGARM FRTGDRARLR
     ADGRLELLGR VDRQVQIRGQ RAEPGEVEHA LLAHPAVRAA AVTANPDATG LWAYVRLAPG
     PFAAGSPQTE LTAFLRRTLP AHLVPTAVTV LDELPVTAHG KTDHARLPAP DPRAGRPAPT
     APRTPTERTV ADVFAGVLGL EGPVGAHDDF FLLGGHSLLA ARSRGGTPRP PRRPDRAERR
     LRGPHRRRSV AARTDAARPG TGPEHTPFVT DPGARHEPFP LTDVQRAYYV GREGGFALGG
     VSTHAYLEIE APRIDVARFT GALRGVIARH PMLRAVIRPD GLQQVLTDVP PYDVAVHDLR
     DLDEPARQRR RAALREEMSH QVVPADLWPL FDVRVSLGPT DALVHVGVDA LICDAHSFGL
     VLAELAARYA DPARRFPPLT ADFRDHVLHQ EALRGTAEYA AAERYWRERL PELPPGPELP
     LAVAPETLGT PRFTRRSGRL DAASWTAVKD RARRAGLSPS GVLLAAFAEV ITAWSGRPRY
     SLMLTVFDRP PLHPDLGRIV GDFTSLSLLE VDHSRPGDFT DRARALQRRL WQDLDHLAVG
     GVTVTRERAL RHDARPGLLT PVVFTSDLPV GETAAEDADG GEGWALGEPV YGVSQTPQVH
     LDHQVAEDRG ELVFNWDAVE DLFAPGALDA MFAAYTASLT RLARSPEAWR RPGTPPLPTA
     QAAVRRRTAA TEAPLPARLL HEAVGDAARR HADLTALVDG DTRMTYRRLT EHARRVGRTL
     RRLGARPGRL VPVVARKGWR QAVAALGVLE SGAAYLPLDP ELPAERLVHL VRRAEAALLL
     TERALLDTLA VPVGVTVLAV DDDAALDADG GPLQSVQNLT DLAYTIFTSG STGEPKGVMI
     DHLGAANTLE CVNRRFGTGP GDAVLAVSSP SFDLAVYDLF GVLAAGGTVV VPAHDRRRDP
     GHWAELIRRE RVTLWNSVPA LGTLLTEYAE ALAPDALRTL RAVLLSGDWI PLGLPDRIRA
     LSAPGATVMS LGGATEASIW SVWYEIGKVH EAWSSIPYGT PMANQRLEVL DEQLRPRPDW
     VPGELYIGGT GVAKGYWRDP EQTSLRFPVH PGSGQRLYRT GDFARHLPDG TLEFLGRQDD
     QVKIGGFRVE LGEVEAALGR LPDVAAGAVI ATGDPRGDRR LVGFAVPARE GGFDAAGLRR
     QLARRLPAYM VPTTLLPLDR LPLTANGKVD RAALQRLVPG RAPAPAEPAT APPARSRAVP
     VPGWLADLWC ELLDVPEADP DANFFALGGT SRVAITLVTR IEARLAVRVP LARLFDARTL
     GGLAETIAEL SAAAEEEPAP AEPVYAPDPA TRHEPFPLTD IQRAYWLGRH RSLSLGGVAT
     HTYLELDVED LDPGRLQTAL RRLIDRHDAL RLVVLPDGRQ QILGDVPPYL LAHTDLRGRA
     DAEAELARVR EHMSHEVRDA SRWPLFDVRT HRLDDVRTRL HLSLDLLIAD AHSVHVLTGD
     LLTFYADPDA ALPPLGCSFR DYVLAVRAHA EGEPRRRALD HWRARLADLP GPPGLPLRCR
     PEELTAPRFA RLTTGLGPDA WARLRRAAAA AELTPAALIC AAFCDVLAQW SDTPRFTLNL
     TTFHRPALLP GVDDLVGDFT TTTLLGVDGE GDTFRDRARR LQDRIWEDLE HRVVSGVEVL
     RMLRRERGTH DAVRMPVVFT STLRAAGPAP RTAPPAWRVR PGYAISQTPQ VLLDHQVSES
     DGRLVCTWDY VADAYPPGLI EAMFGAFEAL LASLAGHDDD AGHDDDAGHD DGPGHDDGPG
     HDDGPGHDDG PGHDDGPGRD DSADHGHSAT HDDSAARNDR EGGGPE
//