ID   Q9FB20_9ACTO            Unreviewed;       494 AA.
AC   Q9FB20;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   01-SEP-2009, entry version 19.
DE   SubName: Full=Hydroxylase BlmF;
GN   Name=blmF;
OS   Streptomyces verticillus.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=29309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC15003;
RX   MEDLINE=20389599; PubMed=10930733;
RX   DOI=10.1111/j.1574-6968.2000.tb09225.x;
RA   Du L., Chen M., Sanchez C., Shen B.;
RT   "An oxidation domain in the BlmIII non-ribosomal peptide synthetase
RT   probably catalyzing thiazole formation in the biosynthesis of the
RT   anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003.";
RL   FEMS Microbiol. Lett. 189:171-175(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC15003;
RX   MEDLINE=20500448; PubMed=11048953; DOI=10.1016/S1074-5521(00)00011-9;
RA   Du L., Sanchez C., Chen M., Edwards D.J., Shen B.;
RT   "The biosynthetic gene cluster for the antitumor drug bleomycin from
RT   Streptomyces verticillus ATCC15003 supporting functional interactions
RT   between nonribosomal peptide synthetases and a polyketide synthase.";
RL   Chem. Biol. 7:623-642(2000).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF210249; AAG02362.1; -; Genomic_DNA.
DR   GO; GO:0030176; C:integral to endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0004597; F:peptide-aspartate beta-dioxygenase activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:InterPro.
DR   GO; GO:0018193; P:peptidyl-amino acid modification; IEA:InterPro.
DR   InterPro; IPR007803; Asp_Arg_b-Hydrxlase.
DR   Pfam; PF05118; Asp_Arg_Hydrox; 1.
PE   4: Predicted;
SQ   SEQUENCE   494 AA;  54455 MW;  AFC7FE12B379B526 CRC64;
     MKDLGRLLLG HAARFRGREL QDVATRALRA SGGENAWVVS VVNTSLRARQ AVDHALRLAP
     RRGLSRLRYP FSAAHHTATP PRTLSLLCPT RERVGNVERF LDSVARTAAA PGRIEALFYV
     DDDDPQLPAY HELFEHARWR YGRIGRCALH VGAPVGVPHA WNHLARNAAG DVLMMANDDQ
     LYIDYGWDTA LDARVTELSA LHPDGVLCLY FDDGQYPEGG CDFPMVTRPW YGTLGYFTPT
     IFQQWEVEKW VFDIADRLHR LYPVPGVLVE HRHYQDYKAP FDATYQRHRM TREKSFADHA
     LFLRTEPDRE AETDRLRAVI ARAGNTPDAD HADHAVHDAE TFWFTGLLRE SHAKLLAELD
     DAPGPAAGAV LFADGSWTGV AYRTHPLATA LLASIPEATL DSGRADLLVV PPGASHHHPD
     GTVDSAFGSD AGLRVLFGLR VPDAAQLRVG DGPVPWGNGQ CLIHDTAAPS TLRNDGTESL
     AALTFVVPRP APGE
//