ID   Q9FB23_9ACTO            Unreviewed;      2675 AA.
AC   Q9FB23;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   19-JAN-2010, entry version 45.
DE   SubName: Full=Peptide synthetase NRPS5-4-3;
GN   Name=blmVI;
OS   Streptomyces verticillus.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=29309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC15003;
RX   MEDLINE=20389599; PubMed=10930733;
RX   DOI=10.1111/j.1574-6968.2000.tb09225.x;
RA   Du L., Chen M., Sanchez C., Shen B.;
RT   "An oxidation domain in the BlmIII non-ribosomal peptide synthetase
RT   probably catalyzing thiazole formation in the biosynthesis of the
RT   anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003.";
RL   FEMS Microbiol. Lett. 189:171-175(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC15003;
RX   MEDLINE=20500448; PubMed=11048953; DOI=10.1016/S1074-5521(00)00011-9;
RA   Du L., Sanchez C., Chen M., Edwards D.J., Shen B.;
RT   "The biosynthetic gene cluster for the antitumor drug bleomycin from
RT   Streptomyces verticillus ATCC15003 supporting functional interactions
RT   between nonribosomal peptide synthetases and a polyketide synthase.";
RL   Chem. Biol. 7:623-642(2000).
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DR   EMBL; AF210249; AAG02359.1; -; Genomic_DNA.
DR   HSSP; P14687; 1AMU.
DR   SMR; Q9FB23; 595-1092, 1111-1604, 1612-2138, 2149-2635.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR006163; Phsphopanteth_bd.
DR   InterPro; IPR006162; PPantetheine_attach_site.
DR   Pfam; PF00501; AMP-binding; 3.
DR   Pfam; PF00668; Condensation; 2.
DR   Pfam; PF00550; PP-binding; 2.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 2.
DR   PROSITE; PS50075; ACP_DOMAIN; 2.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine.
SQ   SEQUENCE   2675 AA;  284026 MW;  86B8D03DF511E7E7 CRC64;
     MSRPAGIVDI ARRHAERTPA RPAYAFLPDG ETESVRFSFA DIDRRARAVA AVLQDRGLAG
     ERVLVAYPSG PEYVQAFLGC LYAGVVAVPC DEPRSGPSAE RLAGIRADAR PALALTAGAP
     EAGLAGLATL DVAGVPDSAA GAWTDPVAGP DALAFLQYTS GSTRRPRGVM VGHGNLLANE
     RCIAAACGHD RDSTFVGWAP FFHDMGLVAN LLQPLYLGSL SVLMPPMAFL QRPARWLRAV
     SRYRAHTSGG PNFAYDLCVD RVGEDERAGL DLSGWKVAYN GAEPVRADTL RRFTDRFAPH
     GFTPGAHFPT YGLAEATLLV ATGPKGVPPR TLTADRAALR AGRLRPAGPG EAGLELVGNG
     TAGLDTTLRI VDPATARECP PGEVGEVWVR GPGVARGYFG RPRESAPLLA ARLPGGEGPY
     LRTGDLGALH DGELFLTGRH KDLIVIRGQN HHPHDLERTA EQAHPALRPT CAAAFAVPGD
     GAERLVLVCE LTSYRAVDPA AVAEAVRAAL AARHGVAPHT LVVLRRGGIP KTTSGKVRRG
     HCRTAYLDGT LPVHTAVRLP AGEEGTEALP LTTDPGRLAT ALRDLAAAHA GLAGPLPGTD
     EPVSALGLDS LASLRLHHHV QSAYGVTLPV TALLGDTTYR RLAELTLAAP RPARAPEGQV
     TGVWRPLTHG QRALWYEQAL APHAAAYHLV RALALRGPVD EEALAEAVRR VVRRHPALRT
     RFALRDGEPA RRTEPYGPEL DVRDATGLPA DRLREHLAAA GDRPFDLAAG DRPVRLTLYR
     TDGGHILLLV AHHLVADFWS LVVLLGDLAR AHAGEDLPPA PEGDPGDEAT DADRTYWRHR
     LADAPPALDL PTDLPHPAER GFAGATHAFR LPPDLTARLT ALSRERHCTL FTTLLAAHQL
     LLHRLTGQDD LVVGTLLARR DTAEAAGAVG YLVNPLPLRS VREPGETFTE LLRRTRRTVL
     DAVAHGRHPF GPLVSRLAPA RTPGRAPLLQ SLFVLQREYG DEADGYRALA LGVGGRLRVG
     GLDLEALALP RRWSQLDLSL SMARLGDGLT GVWEYRTDLF TEATVAELSE AFVHLLRAAV
     EDPGAPVETL PLTGGRETGP RRGPSAARPA LPLHRLVAAA ARRDPARTAV VALAPDGTAH
     HISHGALHRA ATTLAARLRR EGAGPERPVA VLVERGPWLP VAYLGILHAG ATVLPLDPED
     PPHRLARTIA NSGARLLLTE TGTASRAAEA AGPGVRALTV REGATGGERF SADVHPEQSA
     YLLYTSGSTG DPKGVLVPHR AIVNRLLWMQ ETYRLRPGER VLHKTPVTFD VSMWELLWPL
     TAGATVVMAR PGTHRDPARL VRRIAREAVT TVHFVPSMLT PFLTELARGT TRLPALRRVV
     CSGEELPAAA VNRAAGLLDA RLYNLYGPTE AAVDVTAWPC RPPEPGPVPI GLPIANTTTE
     VLDGRLRPLP RPVPGELYLG GACLAHGYHH DPALTAARFL PAPGGGRRYR TGDLVRQRAD
     GALVFRGRTD DQVKIGGIRV EPGEVAEALR ALPGVADAAV VPHDGRLAAY AVADPVGPAP
     AADALRDALR RRLPGHLVPA ALTLLDRLPL TPAGKLDRRA LPHPSAPPPD GGRPPTTGTE
     RLVARVWAER LGREVVGVDR DFFSLGGDSV RALGVTAALR AAGLPVTVTD LLRLPTVAAL
     ARHADERADR RPARQETPPG PFALCPEAAG VPGLEDAYPM SMAQRAVLFH RDHNPGYEVY
     VTSVAVSTPL DRTRLAAAVD RLLDRHAYLR SSFDLVSHPE PTQLVWTHLP TPLEVVESSD
     PAGFDAWLHA ERKRPLDVGT GPLARFTAHD AGAAGFRLTV SSFALDGWCV ATVLTELLRD
     YWSALRGAPL SLPAPAASYR EFVALERAAQ HDPAHREFWR TELAGARPHP LPRRPVPPPG
     PDGIRQHRHV VPVEDTVAKG LSALAGELGV GLKHVLLGVH LRVVRALSGD PDVITAVETH
     GRLERHDGDR VLGVFNNILP LRQRVDGGSW ADLARAAHAA EARTGEYRRY PLAQAQRDHG
     AAGLFDTLFV FTHFHLYRAL ADLDGMAVSD LRAPDQTYVP LTAHFNVDAT DGGGLRLLLE
     SDPREFPDEQ VAEFAAYYRR ALRAAADAPH RPYRDTPLTD RPAGPAPHRA ERSVHALFAA
     PARNHPDRIA LDGEDGPVSH GALARRAARL AGTLRAAGAG PDTVVGIWAP RRADAVVALL
     AALHAGAAYL PLDPVHPPRR QRQVLTEAGA RLLVLPAGLD TPLRACGLPV VAPDDLGAPI
     APVSVHPEQL AAVMATSGST GTPKTIGVPQ RALAGYLRWA IGHYRLDEET VSPVHSSLGF
     DLTVTALLAP LAAGGQARLT DSGDPGALGA ALAAGHHTLL KITPAHLAAL AHQLGAPTAL
     RTVVAGGEPL HAGHVRALRA FAPGARLVNE YGPTETTVGC CAHDVAPDPG EAPIPVGTPI
     AGLSACVVDD ALPAPPGVRG ELYIGGTGVT RGYLGRPAAT AAAYVPDPAA PGARRYRTGD
     LARRLPDGTL LLAGRADRQV KIRGHRVEPG EVEQVLGGHP GVREAAVVAH PAPGGGRRLV
     AYWVPAEPAR PPSADALTAL LADRLPPYAV PAELVRLPAL PTTPNGKVDH TRLPAAGRDR
     RLAELLDRIE ALSDAEAASA LRDSRPAPGS GDDRA
//