ID   Q9FB24_9ACTO            Unreviewed;      1218 AA.
AC   Q9FB24;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   19-JAN-2010, entry version 38.
DE   SubName: Full=Peptide synthetase NRPS6;
GN   Name=blmVII;
OS   Streptomyces verticillus.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=29309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC15003;
RX   MEDLINE=20389599; PubMed=10930733;
RX   DOI=10.1111/j.1574-6968.2000.tb09225.x;
RA   Du L., Chen M., Sanchez C., Shen B.;
RT   "An oxidation domain in the BlmIII non-ribosomal peptide synthetase
RT   probably catalyzing thiazole formation in the biosynthesis of the
RT   anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003.";
RL   FEMS Microbiol. Lett. 189:171-175(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC15003;
RX   MEDLINE=20500448; PubMed=11048953; DOI=10.1016/S1074-5521(00)00011-9;
RA   Du L., Sanchez C., Chen M., Edwards D.J., Shen B.;
RT   "The biosynthetic gene cluster for the antitumor drug bleomycin from
RT   Streptomyces verticillus ATCC15003 supporting functional interactions
RT   between nonribosomal peptide synthetases and a polyketide synthase.";
RL   Chem. Biol. 7:623-642(2000).
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DR   EMBL; AF210249; AAG02358.1; -; Genomic_DNA.
DR   HSSP; P14687; 1AMU.
DR   SMR; Q9FB24; 4-57, 64-500, 514-1007, 937-1087, 1016-1088.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR006163; Phsphopanteth_bd.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF00668; Condensation; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 1.
PE   4: Predicted;
SQ   SEQUENCE   1218 AA;  129640 MW;  F8678E8624753910 CRC64;
     MTTPRITDLL TELRGRQVTL TADGDRLHCR APRGALTDEL LATIRARRDE LLAHLRADRR
     IPRHDGPAPL SFAQERLWLL HQFHPHDSAY NIPLHIALRG PLNPAALRAA LAEVVRRHDV
     LRTRYAISRG LPRPVVEPAH TPPLPLTDLT GLPAHHRDAE LARLAAQEAR RPFDLAQGPV
     LRARLLRTAP EEHRLLLTRH HIASDGWSLD ILLRELGTFY RAGRDGTPAG LDALPLRYAD
     FAAYQREQAE RPETAERSTR WARHLRGAPA TLDVLGPPPA EPSHAPAGTV RTDLPAALVT
     GLRQLGGRAR TTLFPLLLSA FGLALAGPPG PYDVMVGIPV AGRPRTELEP LIGCFATIAP
     MRLTSDGTEP LTRLAARAQQ HVQDALDGPD VPFERLVHAL RPERDLAENP LFSASFAFQN
     TPRTAVRLPG LDAEVLPSPP VAPKFPLALT ATARADGGMG LELEFDRDRI AEPVARGILT
     SFHAALARAV ADPEAPAAPV PAAAVDRRPG REGHECLHEP VARAAARHPD AVAVSCGGTQ
     LSYGALDTRA ERLAAVLRAH GAGPERLVAL CLPTGPEWVV GALAILKSGA AYLPLDPGDP
     AERRASVAAD AGATLIVSDT ALPPLHRVDV TATLPDGAPE PTARAVLPGN LAYAVYTSGS
     TGGPKGVLVT HANVTGLLAA CREALPALDA PRTWSATHSP AFDFSVWEVW GPLTAGGRLV
     LVPPDVARAP DELWDTLRDE QVEVLSQTPS AFHHLLPTAV RRAAQATALE LVVLGGEACE
     PARLTPWWDA LGDRRPAVVN MYGITENTIH VTVRRMTAAD RSGSPVGRPL PGQRADLLDP
     HGRPVAPGGR GELFVGGVGL ARGYLGRPGL TARSFLPDDT PGWPGARRYR SGDLARLLPD
     GGLDYAGRSD AQVKVRGYRV EPAETEAAAL THPAVRHCVV VPRGDGDRRH LAAYVVADTR
     ACDGPGLRTH LAERLPRHLV PASVVFLKRI PLTRNGKLDV AALPDPAAHR APARERPRTA
     TERTLTRLLA ALLKAPPETI GTHDNLFDLG GDSLTVTQFH SRVVEEFAVD LPVRRVYQAL
     DIATLAVTVD DFRRRAERTA VLRALAAAEA MEPGGTAGES GGNPEESAAT ARGPAVAANE
     PGAAARESGA APVEPAVAVQ ESAATKGEPG TAANELGAEA REPGTAAQEP GTDPRPPAAT
     PQDPRTTPQE GQPCPRPE
//