ID   Q9FB27_9ACTO            Unreviewed;      2162 AA.
AC   Q9FB27;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   19-JAN-2010, entry version 43.
DE   SubName: Full=Peptide synthetase NRPS9-8;
GN   Name=blmX;
OS   Streptomyces verticillus.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=29309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC15003;
RX   MEDLINE=20389599; PubMed=10930733;
RX   DOI=10.1111/j.1574-6968.2000.tb09225.x;
RA   Du L., Chen M., Sanchez C., Shen B.;
RT   "An oxidation domain in the BlmIII non-ribosomal peptide synthetase
RT   probably catalyzing thiazole formation in the biosynthesis of the
RT   anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003.";
RL   FEMS Microbiol. Lett. 189:171-175(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC15003;
RX   MEDLINE=20500448; PubMed=11048953; DOI=10.1016/S1074-5521(00)00011-9;
RA   Du L., Sanchez C., Chen M., Edwards D.J., Shen B.;
RT   "The biosynthetic gene cluster for the antitumor drug bleomycin from
RT   Streptomyces verticillus ATCC15003 supporting functional interactions
RT   between nonribosomal peptide synthetases and a polyketide synthase.";
RL   Chem. Biol. 7:623-642(2000).
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DR   EMBL; AF210249; AAG02355.1; -; Genomic_DNA.
DR   HSSP; P14687; 1AMU.
DR   SMR; Q9FB27; 27-456, 473-990, 1556-2052, 2055-2153.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR006163; Phsphopanteth_bd.
DR   InterPro; IPR006162; PPantetheine_attach_site.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF00668; Condensation; 2.
DR   Pfam; PF00550; PP-binding; 2.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 2.
DR   PROSITE; PS50075; ACP_DOMAIN; 2.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine.
SQ   SEQUENCE   2162 AA;  232404 MW;  D9F0CAB3C79A6D96 CRC64;
     MPRCARGALS TAVHTTRQGS WNVMETANSG YRVSPQQRHL WAMLTRGRDG GRRAFTQSAV
     VVDRSLDAAR LRAALASVVA AHEPLRTTFT GLAGRTAPVQ VVHDPDEQPL SVVDLPPSCA
     DGSGPELDEL RLRERAALDP RGGPVFRAAL ARAGEDRAVL VLTAHALVAD RLSLRLLAGQ
     ILAAYSGETV SPDGPPPLQY ADFAAWHHDL LTAEDAAPDR AHWAAHTATA GTGPLPGVVR
     PGAAPGPWRA REWELPAELV AGIDGVAGKL STDPATVLHA AFRIAVWRLA GERNLPVALT
     RDGRSHPELR TAIGAFEREL PLVHEIRHET AFAEYARALD ALVAEGEELL DHCDPELLGS
     LDGTAEGPCF TFTHHQAETP VRRAGITFTT VHQDSGTPIP VRLTARRDGA RLRMELGYDE
     GRIDETFPEN AAACLTRILE GVVSAPEGPV GDIRMLSDET ARLLREAGLG PRVELPGKAV
     HELFAEQAAR TPGAVAVSAG EDALTYAELD ERSNRLAHHL TGLGVTPGRH VVVSVGRSAE
     LLVGLLGVLK AGGAFVPVDV GFPRKRLEFV LRETAAPVLL CTADVRDRIG TRTLDDAGVT
     PVALDADRRR IAAHPAGPTG IATTPDAPAY VVYTSGTTGK PNGVRVPHRG LTNYLTWCTG
     AYGLDGGTGT LVHTSISFDL TLTTLFGPLL AGGQVVMLSE TAGVTGLIAA LRSRRDLTLV
     KLTPTHLDVV NQLLTPDELR GAVRTLVVGG EAVRAESLEP FRASGTRVVN EYGPSETVVG
     SVAHVVDAAT PRTGPVPIGR PIANTTVHLL DQRRRPVPDG VVGELWIGGA GVADGYLGRP
     ELTGERFLPS DYPPDGGRVY RTGDLARRRA DGTLEYLGRT DAQVKIRGVR VEPAETEAVL
     ASHPGVGQAV VVARLDEDPG RSSPLAGELT LTGYVVPARG AQAPPHEELI AYCRERLPEH
     FVPAVLVTLD ALPVTGHGKI DRGALPKPHA RARDGAAYVA PRTATEEILA ATVAKVLGVE
     RVGIDDNYFV LGGDSIRSVM VASRAQARGV EVTVADLHRH PTVRACAAHL DAREDLPRTP
     VTEPFALISA EDRALVPDDV EDAFPLNLLQ EGMIFHRDFA AKSAVYHAIA SVRLRAPFDL
     AVLRMVVRQL VERHPMLRTS FDMSRFSRPL QLVHREFADP LHYEDLRGRS AEEQDARVEE
     WIEREKERGF ELHEFPLIRF MAQRLEDDVF QFTYGFHHEI VDGWSEALMI TELFSHYFSV
     IYDEPIAIKP PTAGMRDAVA LELEALADRR NYEFWDSYLA DATLMRLPRP GTGPRADKGD
     RDITRIAVPV PTELSDGLKR VAATHAVPLK TVLLAAHMVV MSLYGGHEDT LTYTVTNGRP
     ETADGSTAIG LFVNSLALRV RMTGGTWADL ITATLESERA SMPYRRLPMA ELKRHQGNEP
     LAETLFFFTN YHVFHVLDRW IDRGVGHVAN ELYGESTFPF CGIFRLNRET GELEVRIEYD
     SLQFSDALME SVRDSYARVL AALVADPDGR YDRHEFRSDR DRAALAVLTR GPEAPAADRC
     LHDLVADRAA DRPDAPAVQL DTDVLSYGEL DRRANRLAHH LRSLGIGPES VVGVLAERSL
     AQIIGLLAVL KAGAAYVPLD PAQPDERLAA VIAGSGAAAV LHRPGLEGRL PAGVRALPTD
     AADGSTATHD PGPTATPRNA AYVMYTSGST GEPKGIVVEH RNVVASLAAR GAHYAAGPGR
     FLLLSSFAFD SSVAGIFWTL TQGGTLVLPG EGQQLDPAAL VETIARQRPT HTLAIPSLLA
     PVLDQAAPGD LASLRTVIAA GESCPAELAA ACRDLLPGST FHNEYGPTET TVWSTVWSQE
     NEHDGPHLPI GRPVAGTWVH PRDHRGRTVP LGVAGELSIG GAGVARGYLG RPRDTAAAFR
     PDPEATAPGG RAYATGDLGR YLPDGNLEFL GRADHQVKIR GFRVELGEIE AVLDTHPELQ
     RTIVMARGDH PGDQVLVAYV LPAPGRRPEP ADIQGYVRDR LPRYMVPTAV IVLDAVPLTA
     AGKVDRASLP APSHAQLTRD QEYVEPGTDT ERALAAIWAD VLKLDRIGAG DRFFDVGGES
     LRAMQATAAA NKMFRTRVSV RRLFEAPSLR EFAHEIDKAR LAGGGTGLTG PAAAPATGGA
     AE
//