ID   Q9KIZ5_SORCE            Unreviewed;      2439 AA.
AC   Q9KIZ5;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   19-JAN-2010, entry version 53.
DE   SubName: Full=EpoF;
GN   Name=epoF;
OS   Sorangium cellulosum (Polyangium cellulosum).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Sorangiineae; Polyangiaceae; Sorangium.
OX   NCBI_TaxID=56;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SMP44;
RX   MEDLINE=20115953; PubMed=10649995; DOI=10.1126/science.287.5453.640;
RA   Tang L., Shah S., Chung L., Carney J., Katz L., Khosla C., Julien B.;
RT   "Cloning and heterologous expression of the epothilone gene cluster.";
RL   Science 287:640-642(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SMP44;
RX   MEDLINE=20293058; PubMed=10831849; DOI=10.1016/S0378-1119(00)00149-9;
RA   Julien B., Shah S., Ziermann R., Goldman R., Katz L., Khosla C.;
RT   "Isolation and characterization of the epothilone biosynthetic gene
RT   cluster from Sorangium cellulosum.";
RL   Gene 249:153-160(2000).
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DR   EMBL; AF217189; AAF62885.1; -; Genomic_DNA.
DR   HSSP; P96202; 1PQW.
DR   SMR; Q9KIZ5; 17-903, 1809-2164.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:InterPro.
DR   InterPro; IPR001227; Ac_transferase_dom.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPlipase.
DR   InterPro; IPR013154; ADH_GroES-like.
DR   InterPro; IPR013149; ADH_Zn-bd.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR011032; GroES-like.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR006163; Phsphopanteth_bd.
DR   InterPro; IPR020842; PKS/FAS_KR.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_reg.
DR   InterPro; IPR020807; PKS_dehydratase.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR006162; PPantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   Gene3D; G3DSA:3.40.366.10; Ac_transferase_reg; 1.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 2.
DR   Gene3D; G3DSA:3.40.47.10; Thiolase-like_subgr; 2.
DR   PANTHER; PTHR11712; Ketoacyl_synth; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 1.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine; Transferase.
SQ   SEQUENCE   2439 AA;  257510 MW;  D3A972BC49FC3497 CRC64;
     MATTNAGKLE HALLLMDKLA KKNASLEQER TEPIAIIGIG CRFPGGADTP EAFWELLDSG
     RDAVQPLDRR WALVGVHPSE EVPRWAGLLT EAVDGFDAAF FGTSPREARS LDPQQRLLLE
     VTWEGLEDAG IAPQSLDGSR TGVFLGACSS DYSHTVAQQR REEQDAYDIT GNTLSVAAGR
     LSYTLGLQGP CLTVDTACSS SLVAIHLACR SLRARESDLA LAGGVNMLLS SKTMIMLGRI
     QALSPDGHCR TFDASANGFV RGEGCGMVVL KRLSDAQRHG DRIWALIRGS AMNQDGRSTG
     LMAPNVLAQE ALLRQALQSA RVDAGAIDYV ETHGTGTSLG DPIEVDALRA VMGPARADGS
     RCVLGAVKTN LGHLEGAAGV AGLIKAALAL HHESIPRNLH FHTLNPRIRI EGTALALATE
     PVPWPRAGRP RFAGVSAFGL SGTNVHVVLE EAPATVLAPA TPGRSAELLV LSAKSTAALD
     AQAARLSAHI AAYPEQGLGD VAFSLVATRS PMEHRLAVAA TSREALRSAL EAAAQGQTPA
     GAARGRAASS PGKLAFLFAG QGAQVPGMGR GLWEAWPAFR ETFDRCVTLF DRELHQPLCE
     VMWAEPGSSR SSLLDQTAFT QPALFALEYA LAALFRSWGV EPELIAGHSL GELVAACVAG
     VFSLEDAVRL VVARGRLMQA LPAGGAMVSI AAPEADVAAA VAPHAASVSI AAVNGPEQVV
     IAGAEKFVQQ IAAAFAARGA RTKPLHVSHA FHSPLMDPML EAFRRVTESV TYRRPSMALV
     SNLSGKPCTD EVCAPGYWVR HAREAVRFAD GVKALHAAGA GIFVEVGPKP ALLGLLPACL
     PDARPVLLPA SRAGRDEAAS ALEALGGFWV VGGSVTWSGV FPSGGRRVPL PTYPWQRERY
     WIEAPVDGEA DGIGRAQAGD HPLLGEAFSV STHAGLRLWE TTLDRKRLPW LGEHRAQGEV
     VFPGAGYLEM ALSSGAEILG DGPIQVTDVV LIETLTFAGD TAVPVQVVTT EERPGRLRFQ
     VASREPGARR ASFRIHARGV LRRVGRAETP ARLNLAALRA RLHAAVPAAA IYGALAEMGL
     QYGPALRGLA ELWRGEGEAL GRVRLPESAG SATAYQLHPV LLDACVQMIV GAFADRDEAT
     PWAPVEVGSV RLFQRSPGEL WCHARVVSDG QQAPSRWSAD FELMDGTGAV VAEISRLVVE
     RLASGVRRRD ADDWFLELDW EPAALEGPKI TAGRWLLLGE GGGLGRSLCS ALKAAGHVVV
     HAAGDDTSAA GMRALLANAF DGQAPTAVVH LSSLDGGGQL DPGLGAQGAL DAPRSPDVDA
     DALESALMRG CDSVLSLVQA LVGMDLRNAP RLWLLTRGAQ AAAAGDVSVV QAPLLGLGRT
     IALEHAELRC ISVDLDPAQP EGEADALLAE LLADDAEEEV ALRGGERFVA RLVHRLPEAQ
     RREKIAPAGD RPFRLEIDEP GVLDQLVLRA TGRRAPGPGE VEIAVEAAGL DSIDIQLAVG
     VAPNDLPGGE IEPSVLGSEC AGRIVAVGEG VNGLVVGQPV IALAAGVFAT HVTTSATLVL
     PRPLGLSATE AAAMPLAYLT AWYALDKVAH LQAGERVLIR AEAGGIGLCA VRWAQRVGAE
     VYATADTPEK RAYLESLGVR YVSDSRSGRF AADVHAWTDG EGVDVVLDSL SGEHIDKSLM
     VLRACGRLVK LGRRDDCADT QPGLPPLLRN FSFSQVDLRG MMLDQPARIR ALLDELFGLV
     AAGAISPLGS GLRVGGSLTP PPVETFPISR AAEAFRRMAQ GQHLGKLVLT LDDPEVRIRA
     PAESSVAVRA DGTYLVTGGL GGLGLRVAGW LAERGAGQLV LVGRSGAASA EQRAAVAALE
     AHGARVTVAK ADVADRSQIE RVLREVTASG MPLRGVVHAA GLVDDGLLMQ QTPARLRTVM
     GPKVQGALHL HTLTREAPLS FFVLYASAAG LFGSPGQGNY AAANAFLDAL SHHRRAHGLP
     ALSIDWGMFT EVGMAVAQEN RGARLISRGM RGITPDEGLS ALARLLEGDR VQTGVIPITP
     RQWVEFYPAT AASRRLSRLV TTQRAVADRT AGDRDLLEQL ASAEPSARAG LLQDVVRVQV
     SHVLRLPEDK IEVDAPLSSM GMDSLMSLEL RNRIEAALGV AAPAALGWTY PTVAAITRWL
     LDDALAVRLG GGSDTDESTA SAGSFVHVLR FRPVVKPRAR LFCFHGSGGS PEGFRSWSEK
     SEWSDLEIVA MWHDRSLASE DAPGKKYVQE AASLIQHYAD APFALVGFSL GVRFVMGTAV
     ELASRSGAPA PLAVFALGGS LISSSEITPE METDIIAKLF FRNAAGFVRS TQQVQADARA
     DKVITDTMVA PAPGDSKEPP SKIAVPIVAI AGSDDVIVPP SDVQDLQSRT TERFYMHLLP
     GDHEFLVDRG REIMHIVDSH LNPLLAARTT SSGPAFEAK
//