ID Q9L4W3_9ACTO Unreviewed; 11096 AA.
AC Q9L4W3;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 19-JAN-2010, entry version 52.
DE SubName: Full=NysC;
GN Name=nysC;
OS Streptomyces noursei.
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Streptomycineae; Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1971;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 11455;
RX MEDLINE=20334850; PubMed=10873841; DOI=10.1016/S1074-5521(00)00120-4;
RA Brautaset T., Sekurova O.N., Sletta H., Ellingsen T.E., StrLm A.R.,
RA Valla S., Zotchev S.B.;
RT "Biosynthesis of the polyene antifungal antibiotic nystatin in
RT Streptomyces noursei ATCC 11455: analysis of the gene cluster and
RT deduction of the biosynthetic pathway.";
RL Chem. Biol. 7:395-403(2000).
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DR EMBL; AF263912; AAF71776.1; -; Genomic_DNA.
DR HSSP; P96202; 1PQW.
DR GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0055114; P:oxidation reduction; IEA:InterPro.
DR InterPro; IPR001227; Ac_transferase_dom.
DR InterPro; IPR009081; Acyl_carrier_prot-like.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPlipase.
DR InterPro; IPR013154; ADH_GroES-like.
DR InterPro; IPR013149; ADH_Zn-bd.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR InterPro; IPR011032; GroES-like.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR006163; Phsphopanteth_bd.
DR InterPro; IPR020842; PKS/FAS_KR.
DR InterPro; IPR020801; PKS_acyl_transferase.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_reg.
DR InterPro; IPR020807; PKS_dehydratase.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR006162; PPantetheine_attach_site.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR016038; Thiolase-like_subgr.
DR Gene3D; G3DSA:3.40.366.10; Ac_transferase_reg; 6.
DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 7.
DR Gene3D; G3DSA:3.40.47.10; Thiolase-like_subgr; 12.
DR PANTHER; PTHR11712; Ketoacyl_synth; 1.
DR Pfam; PF00698; Acyl_transf_1; 6.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00106; adh_short; 2.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF00109; ketoacyl-synt; 6.
DR Pfam; PF02801; Ketoacyl-synt_C; 6.
DR Pfam; PF08659; KR; 4.
DR Pfam; PF00550; PP-binding; 6.
DR SMART; SM00827; PKS_AT; 6.
DR SMART; SM00826; PKS_DH; 6.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 6.
DR SMART; SM00825; PKS_KS; 6.
DR SMART; SM00823; PKS_PP; 6.
DR PROSITE; PS50075; ACP_DOMAIN; 6.
DR PROSITE; PS00606; B_KETOACYL_SYNTHASE; 6.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Phosphopantetheine; Transferase.
SQ SEQUENCE 11096 AA; 1150432 MW; 776CAEAFCAE551DD CRC64;
MSTNPDKYVE ALRSSLKEIE RLRRQNEQLV AAAVEPVAVV GIGCRFPGGV TSPEDLWELV
AEGRDVIGPF PQDRGWDLEK LAGGGEGGSL AQVGGFVEDA AGFDPGFFGI SPREAVAMDP
QQRILLEITW EALERAGIDP STLRGTPTGV FVGTTGQDYG EVIKASAEDV EVYSTTGHAA
SVISGRLSYT LGAEGPAVTV DTGCSSSLVA LHWAVQALRG GECSMALAGG ASIMATPGPF
VAFTAQSGLA ADGRCKPFSD RADGTGWGEG AGMLVLMRLS DAQREGRPVL AVLRGSAINQ
DGASNGLTAP NGPSQQRVIR AALDSAHLTA ADIDAVEAHG TGTTLGDPIE AQALLATYGQ
DRPRPLWLGS VKSNIGHTQA ASGAAGVIKM IMALQRGVLP RSLHATEPTT DVDWTAGSVD
LLDETVAWPE TGRARRAGVS SFGISGTNAH VILEQAPTAP EEPTTEPTVR PAVVPWALSA
RTAAALDAQR ARLTGHLADT PDADPLDVGY ALADGRATFE HRAVLLPDGT ELAHGTAGEG
PCAVLFSGQG SQRPGMGREL HARFPVFAAA FDEITALLDT HLDRPLREVV WGTDADLLND
TGWAQPALFA VEVALYRLVA SLGVTPDFVG GHSIGELAAA HVAGVLSLED ACTLVAARAR
LMQALPRGGA MLAIRATEDE VTPHLTDDVS IAAVNGPTSV VVAGTEEAVA AIGARFTAQD
RKTTRLRVSH AFHSPLMDPM LAEFRAVAAG LTYHEPRIPV LSNLTGTVAA VADLCSADYW
VRHVREAVRF ADGVTALTDR GVTTLVELGP DGVLSAMAQE SLPDGAAAVP LLRKDRPEEL
SAVTGLARAH VRGVTVRWAG LFDGTGARRA DLPTYPFQHQ RFWPTAARAA QDVTAAGLGA
ADHPLLGATV ELADGAGYLF TSRLSVRTHP WLADHGVQGR ALLPGTAFVE LAVRAGDEAG
CDRVEELTLA APLVLPERGG VQLQVRVGAP DAAGRRTLGI FSRVEDGFDL PWSQHATGVL
TAGAGAPDPT FDATVWPPSG AEPVDLTGAY ERLAALGFQY GPAFQGLRAA WRRDTEVYAE
VALPDGADTD PAAFGLHPAL LDAAQHAAAY ADLGAISRGG LPFAWEGVSL AAAGATTVRA
RIAPAGEDTV TIAVYDAAGG TVLSVDSLVS REVPADAPGA AGTVHRDSLF HVEWTPLQGR
PGPAPATVAV LGPDPDALAD TLRATGIRTT APRDLAALAD AEGPVPDLVV TTLTTTPGAP
VPDAAHATTA AVLALAQQWL ADDRFADARL VLVTRGATDG TDPAAAAAGG LIRTARTENP
GRFALLDLAP DTGRPDPETL ATALAASHDE PDLAVRGTDV HAARLARVPL ATEPTTWNPD
GTVLITGGTG GLGAVLARHL VATHGVRHLL LASRRGPAAD GADDLTAELT GLGATVHIAA
CDVADPAALA DLLGTVPAGH PLTVVVHTAG VVDDGVLGSL TPQRLDTVLR PKADAAWHLH
EATRHLDLDA FVLFSSVAAT LGSPGQANYA AGNAFLDALA ARRAATGLPA TSLAWGPWTQ
SVGMTSSLSD LDVERIARSG MPPLTLEQGT ALFDAALAAG PAALAPVRLD LPVLRTQGDI
APLLRGLIRT PVRRTAAQVS QTADGLAQRL AGLDAAARRE ALLELVRTQI AQVLGHADAT
EVETGRQFQD LGFDSLTAVE LRNALNTATG LRLPATMVFD YPTPHALADH LRDELLGTEA
ESTTAVPVPT RTAGTDDPIV IVGMACRYPG GIASPEDLWR LVSQGADATG PFPTNRGWDL
DNLYDPDPDR PGRTHVRAGG FLHDAGSFDA DFFGMSPREA MATDSQQRLL LELSWEAVER
AGIDPASLRD SGTGVFAGVM YNDYGTTLTG DEYEAFRGNG SAPSVASGRV SYTLGLEGPA
VTVDTACSSS LVALHWAAQA LRAGECSLAL AGGVTVMSTP STFVEFSRQR GLAPDGRSKA
FAEAADGVAW SEGVGMLVLE RQSDAVRNGH EILAVVRGSA VNQDGASNGL TAPNGPSQQR
VIRQALASGG LSTADVDAVE AHGTGTTLGD PIEAQALLAT YGRDRDPENP LLLGSIKSNI
GHTQAAAGVA GVIKMVMAMR HGVLPQTLHV DAPSSHVDWS VGAVELLTEQ TAWPETGRAR
RAGVSSFGIS GTNAHVVIEQ SPTAVPATPA SADRSVEEPP AVPWALSGKT PDALRDQAAR
LLAHVEAHPA LRPVDISYSL IATRTAFDHR AVVLGTDRAE ALRALTALAA GETDPAALTG
TVRTGRTAFL FSGQGSQRLG MGRVLYERFP AFAEALDTVL TALDAELGHP LRDIIWGEDA
QLVDRTGYTQ PALFAIEVAL FRLLEAWGIT PDFVAGHSIG EIAAAHVAGV LSLGDACRLV
VARAVLMQSL PEGGAMIAVQ ATEDEVLPLL TDDVSIAAVN SPTSVVVSGY ENATLAVARH
FADQGRRTTR LRVSHAFHSP LMAPMLDDFR AVVESLTFTA PTTPVVSNLT GELAPAEALC
SADYWVRHVR EAVRFADGIR TLADRGVTTF VELGPDSVLS AMAQESAPEG AGTIPLLRRD
RPEEQAVLAA LCHLQVLGVE ADWSATFRGL DPVRVDLPTY AFQHRWFWPA ARPARPDDVR
AAGLGAAEHP LLGAAVQLPD DDGALFTGRL SLRTHPWLAD HTVLGTVLLP GTALVELAVR
AGDETGSGHL EELTLAAPLT LPEDGATLLQ VRVGSADDTG RRTVTVHARP DDTADRTWTL
HATGVLATTP PAAAAFDTTV WPPADAEPLT TDDCYAHFTT HRFAYGPAFQ GLRAAWRAGD
VLYAEVALPE SATDEAAAFG LHPALLDAGL HAALLADDRD TGLPFSWEGV TLHASGATAL
RVRLAPNGPN GLSVTAADPA GNPVATVTRL LARPLDAEQL TIHSALTRDA LFHLDWTPVP
LPDTANSAPP ALLGPDTAVL ADALGDPAVA RHATLDDLLA GDTTPPATVL VPLGAPLDGD
TAQHAHALTR SALTLVQQWL ATDRLADSRL VFVTHGAVAT DDAPPTDLAA AAVWGLIRSA
QTENPGTFTL LDLDTEPDST TALSRALTLD EPQLLLRAGR ARAARLTRTP APTTTTHTPW
SADGTVLVTG GTGGLGGLVA RHLVRSCGVR HLLLTSRSGV GAAGAAGLVA ELESLGARVV
VAACDVGDGS AVAELVAGVS ESYPLSAVVH AAGVLDDGVV GSLTPERLAA VLRPKVDGAW
NLHEATRGLD LDAFVVFSSV AGVFGGAGQA NYAAGNAFLD ALMVHRVAGG LPGVSLAWGA
WDQGVGMTAG LTERDVRRAA ESGMPLLTVD QGVALFDAAL ATGSAALVPV RLDLAALRTR
GDIAPLLRGL VRAPLRRTAA TGLATGADTG LVQRLGRLDH AQRHEALLDM VRSSAALVLG
HADGNAIDAE RAFRDLGFDS LTAVELRNRL RTATGLHLSA TMVFDHPTLS ALAEHLRDEL
FGAVESEVRV PVQALPPTAD DPIVVVGMAC RFPGGVTSPE DLWRLVDDGT DAITTFPTNR
GWDLDNLYDP DPEHFGTSYT RSGGFLHEAG EFDPAFFGMS PREALATDSQ QRLLLESSWE
AIERAGIDPL TLRGSATGVF AGVMYSDYGS ILGGKEFEGF QGQGSAGSVA SGRVSYALGF
EGPAVTVDTA CSSSLVALHW AAQALRAGEC SLALAGGVTV MSTPSTFVEF SRQRGLAPDG
RSKAFAEAAD GVGWSEGVGI LVLERQSDAV RNGHEILAVI RGSAVNQDGA SNGLTAPNGP
SQQRVIRQAL ASGGLSTADV DAVEAHGTGT TLGDPIEAQA LLATYGRDRD PENPLWLGSL
KSNIGHTQAA AGVAGVIKMV MAMRHGVLPQ TLHVDAPSSH VDWSVGAVEL LTEQTAWPET
GRVRRAGVSS FGISGTNAHV IVEQPALVES PAAEPSGREP GVVPLPLSGK SPEALRDQAA
RLLAGLAERP ALRPLDLGYS LATTRSAFDH RAVVLATDRA DAVRALTALA AADADLSAVV
GDTRTGRHAV LFSGQGSQRL GMGRELYERF PVFAEALDVA IDHLDAALPA QASLREVMWG
DDVELLDETG WTQPALFAVE VALFRLVESW GVRPDFVAGH SIGEIAAAHV VGVFSLEDAC
RLVAARATLM QALPTGGAMI AIQAAEDEVT QHLTDDVSIA AVNGPTSVVV SGAESAARTV
ADRLAENGRK TTRLRVSHAF HSPLMDPMLA EFRAVAEGLS YATPTLPVVS NLTGRLATAD
DLCSAEYWAR HVREAVRFAD GVSTLENEGV TTFLELGPDG VLSAMAQQSL TGDAATVPAL
RKDRDEETSA LTALAHLHTA GLRVDWAAFF AGSGATRVDL PTYAFQHATY WPTGTLPTAH
AAAVGLTAAE HPLLNGSVEL AEGEGVLFTG RLSLQSHPWL ADHAVMGQVL LPGTALLELA
FRAGDEAGCD RVEELTLAAP LVLPERGAVQ TQVRVGVADD TGRRTVTVHS RPEHATDVSW
TQHATGTLTM GSAPADTGFD ATAWPPADAE PLATDDCYAR FTTLGFAYGP VFQGLRAAWR
AGDVLYAEVA LAESTGDEAT AFGLHPALLD AALHASLVAH EGEESNGGLP FSWEGATLYA
TGATALRVRL TPTGTDGRSV AIAVADTAGR PVAAIDNLVS RRVSGDQLTG AAGLARDALF
TLDWNPVPEN LVPENPVPEN TGGGHAQDQD GRPAAATVAL VGADGTAIAA DLTAAGIHTT
LHPDLTTLAT TDADVPKTVL IPLTGTGTGT GTGTESTDGI GTGAAESDAS APSPAEVAHT
LSTAALALVQ EWTAQERFAG SRLAFVTTGA TAAGGTDVMD VAAAAVWGLV RSAQSEAPDT
FVLIDRDPGP AGTHDRTAAA ERGQLLLRAL HTDEPQLALR DGGVLAARLA RFDTAAALTP
PADRAWRLDS TAKGSLNGLA LTPYPAALAP LTGHEVRVEV RAAGLNFRDV LNALGMYPGD
DVGSFGSEAA GVVVEVGPEV TGLAPGDQVM GMITGSFGSL AVDDARRLAR LPEDWSWETG
ASVPLVFLTA YYALKELGGL RAGEKVLVHA GAGGVGMAAI QIARHVGAEV FATASEGKWD
VLRSLGVADD HIASSRTLDF EAAFAEVAGD RGLDVVLNSL AGDFVDASMR LLGDGGRFLE
MGKTDIRAAD SVPDGLSYQS FDLAWVVPET IGTMLAELMD LFRTGALRPL PVRTWDVRHA
KDAFRFMSMA KHIGKIVLTL PRSWKPEGTV LVTGGTGGLG GLVARHLVRS CGVRHLLLTS
RSGVGAAGAA GLVAELESLG ARVVVAACDV GDGSAVAELV AGVSESYPLS AVVHAAGVLD
DGVVGSLTPE RLAAVLRPKV DGAWNLHEAT RGLDLDAFVV FSSVAGVFGG AGQANYAAGN
AFLDALMVHR VAGGLPGVSL AWGAWDQGVG MTAGLTERDV RRAAESGMPL LTVDQGVALF
DAALATGSAA LVPVRLDLAA LRTRGDIAPL LRGLVKAPIR RAAATTPGDT GLAEQLTRLQ
RAERRDTLLA LVRDQAAMVL GHTSGDGVDP SRAFRDLGFD SLTAVELRNR IGAATGLRLP
ATAVFDYPTA DALAAHLLTE LLGPDAESDP DEPGDPTAGP TDDPIVIIGM SCRFPGDIGS
PEDLWRLLGD GADVVTDFPT NRGWDLDNLY DPDPAHAGTS YARTGGFLHD AADFDADFFG
MSPREAMATD SQQRLLLESS WEAIERAGID PLTLRDSRTG VFAGVMYSGY GTRLDGAEFE
GFQGQGSALS VASGRVSYTF GFEGPAMTVD TACSSSLVAL HLAAQALRGG ECTLALAGGV
TVMSIPDTFI EFSRQRGLAP DGRSKPFSES ADGVGWSEGV GMLLLERQSD AVRNGHQILA
VVRGSAVNQD GASNGLTAPN GPSQQRVIRQ ALASGGLSTA DVDAVEAHGT GTTLGDPIEA
QALLATYGRD RDPENPLLLG SIKSNLGHTQ AAAGVAGVIK MVMAMRHGVL PRSLNITEPS
SHVDWSAGAV ELLTEQTAWP ETGRARRAGI SSFGISGTNA HVILEQPEAA RHSAPEEADT
AEAAAKAPAT AHLPVMPWAL SGKTPEALRA QAARLLAHLQ QRPELAPADI ALSLATQRSQ
FTHRAVVLST DRDEATRALS ALATTAASDP SALTGTVTMG RCAVLFSGQG SQRLGMGREL
YERFPVFAEA LDVVIDHLDA ALPAQAGLRE VMWGDDVELL NETGWTQPAL FAIEVALFRL
VESWGVRPDF VAGHSIGEIA AAHVVGVFSL EDACRLVAAR ATLMQALPAG GAMIAVQATE
DEVIPHLTDE VAIAAVNGPT SVVISGAEEA TQTVAQHFAD QGRRTTALRV SHAFHSPLMM
LAEFRAVAEG LSYATPTLPV VSNLTGQVAT ADELCSAEYW VRHVREAVRF ADGVTALEAE
GVRTFLELGP DGVLAAMARE TVADDTVTVP VLRRNMPEER TLLTALGRLH TTGTPIDWAA
LLAPTGARPV DLPTYAFQHR PFWPSGPRDT ADAAAVGIAG ASHPLLNGIV ELADEEGLLF
TGRLSLQSHP WLADHAVMGQ VLLPGTALLE LALRAGDEVG CDHVEELTLA APLVLPERGA
VQTQVRVGVA DTTGRRTVTI HSRPARATTT DSDTHTGTDT PWTQHATGVL VAGLPATATV
PFDATVWPPA HAEPVDLADF YASRAGEGFG YGPAFQGLRA AWRRDGEVFA DVALPEAGRT
EAEAYGLHPA LLDAGLHAAW LVAPDGEPTR TGSVPFSWRG VFLAASGASS VRVRLGRDSD
GTLSLAIADT TGAPVASVQA LSMRTVSVTA LSATAGLARD ALFRLDWASA PEPACQPDDT
VTVIPAVAVV GTETSELTSE LTAALRAAGA DVDVRTTLST DEPAPALIAL PLVASDQTGT
AEAAPVPAAV HDLTRRALAL VQTRLQEQHF ADTKFVFVTR GATVGRDVAA AAVWGLVRSA
QSENPGCFAL VDLDPDGAVG AAALVAALVS GEPQLAVRGD VLRVARLVRR PLTEVGAGAD
GTGDGVGGGS GVSFSGEGAV LVTGGTGGLG AVLARHLVAE YGVRDLLLVS RSGERAVGAG
ELVAELAGVG ARVRVVACDV TDRAAVVELV GGHAVSAVVH AAGVLDDGMV GALTGERLSA
VLRPKVDAVW HLHEATRGLD LDAFVVFSSL AGVFGSPGQA NYAAANAFLD ALMTRRRAEG
LPGLSLAWGP WSLTDGTSGM LADAEADRLT RSGVPPLTAE QGLALFDAAL ATGDATCVPV
RLDLSALRAQ GEVPPLLRSL IRGRSRRAAA AESATATGLR ERLVGLNPVE RQEVLLDLVR
GQVALVLGHA DADDVHPARA FRELGFDSLT SVELRNRLNT VTGLRLPATM VFDYPTVEVL
VSYVLDELLG TDAEVATVQP AAVAVADDPI VIVGMACRYP GGVASPDDLW RLVTDGVDAV
SPFPTNRGWD VESLYHPDPD HLGTSYTRSG GFLHEAGEFD PGFFGMSPRE ALATDSQQRL
LLESSWEAIE RAGIDPVSLR GSRTGVFAGV MYSDYSAMLA SPEFEGFQGS GSSPSLASGR
VAYTLGLEGP AVTVDTACSS SLVAMHWAMQ ALRSGECGLA LAGGVTVMST PAVFVDFARQ
RGLSPDGRCK AFADAADGVG WSEGVGVLVL ERQSDAVRNG HEILAVVRGS AVNQDGASNG
LTAPNGPSQQ RVIRQALASG GLTAGDVDVV EAHGTGTTLG DPIEAQALLA TYGRDREPER
PLLLGSVKSN LGHTQAAAGV AGVIKMVLAM RHGVVPRTLH VDAPSSHVDW SEGAVELLSE
QAAWPETGRV RRAGVSSFGI SGTNAHVILE RPEAARRPVM ETNTVEPSTV PWVLSGKTPE
ALRAQAAKLL SSIEERPELR LVDVGMSLVT GRSTFEHRAV VLAADRADAA RALSAIAADE
ADAAAATGRV GAGRHAVLFS GQGAQRLGMG RELYERFPVF AEALDVVVDH LDAALPAQAG
LREVMWGDDA ELLNETGWTQ PALFAIEVAL FRLVESWGVR PDFVAGHSIG EIAAAHVAGV
FSLEDACRLV AARATLMQAL PAGGAMIAVQ ATEDEVTPHL TDDVAIAAIN GPNALVVSGV
EDAAVEIGAR FAAEGRRTTR LHVSHAFHSP LMDPMLAEFR VVAEGLSYAA PSLPVVSNLT
GQVATADELC SAEYWVRHVR EAVRFADGVT ALEAEGVRTF LELGPDGVLA AMAGASLTES
SLAVPLLRKD RPEEPAALAA LAQLHIAGAR VDWPVLFAGV GAGRVELPTY AFQRGWFWPV
GRVGVGGDVG AVGLGSAGHP LLGAAVELAA GAGVVLTGRL SLSSHGWLAD HAVMGRVFVP
GTALLEMVMR AGDEVGCGRV EELTLAAPLV LPERGGVRVQ VAVDAPDAAG RRGVGVYSCP
DGVGQAVWSQ HAVGVLASGV ADQVGGFGDG GVWPPQGAVS VDAEGCYELF ADAGFGYGPV
FQGLRAVWRR GEELFAEVAL SDEVAESADT ATGFGLHPAL LDASLHASLL SSLEGQSADG
GPALPFAWEG VSLFASGATA LRVRLAPAGE HAVSVTAVDP TGAPVISIDA LRTRRLTLDE
VNASHTQLSD ALFGVQWTTV PSTPAADHPS VAIIGTDHLG LAEALSSSSA GATTTTTAAA
YESLDALIAA GPEVSVPDVT LIGLTTEDAI AQYVNDHDAT VAGQGTIGAG AAAVDAARRL
TAEALRTIQA WLADERLAAR RLVFVTRGAA DGQDVAAAAV QGLVRSAQTE NPGTFGLLDL
DGTEASTAVL GEALTSDEPQ LLLRDGHLHA ARLTRLASPA DTAVPTEWNA DGTVLITGGT
GGLGAQFARH LVDRYGVRNL LLVSRRGPDA PGTTELVAEL TAHGAEVAVQ ACDVADGDAV
AALVAGVPDE HPLRAVVHTA GVLDDGVIGS LTEERLATVL RPKADAAWHL HEATRGLDLD
AFVVFSSVAG VFGGAGQANY AAANAFLDAL MAQRRAAGLP GLSLAWGPWD QTGGMTGMLS
DAEADRLARS GIPPLSAEQG LALFDAALAL AGTSTPDRAA GSAAASTSGT GDTIAIPAAA
LVAPVRLDLA ALAAQGEVPA ILRGLVRTRT RRTAAGGSVT VAGLVNRLSG LTADERRQEL
LELVRTQAAL VLGHADPASV DSTAQFRDLG FDSLTAVELR NRLSTATGLR LTATLVFDYP
NTDALAEHLR DELFGAVESE VRVPVQALPP TADDPIVVVG MACRFPGGVT SPEDLWRLVD
AGTDAITTFP TNRGWDLESL YDPDPAHLGT SYTRSGGFLH EAGEFDPAFF GMSPREALAT
DSQQRLLLES SWEAIERAGI DPLTLRGSAT GVFAGVMYSD YGSILGGKEF EGFQGQGSAG
SVASGRVSYT LGFEGPAVTV DTACSSSLVA LHLAAQALRA GECTLALAGG VTVMSTPGTF
VEFSRQRGLA PDGRSKAFAE AADGVGWSEG VGILVLERQS DAVRNGHEIL AVIRGSAVNQ
DGASNGLTAP NGPSQQRVIR QALASGGLST ADVDAVEAHG TGTTLGDPIE AQALLATYGR
DRDPENPLLL GSIKSNLGHT QAAAGVAGVI KMVMAMRHGV LPQTLHVDAP SSHVDWSVGA
VELLTEQTVW PETGRVRRAG VSSFGISGTN AHVILEQPEA VQRLAPGAAE TVEPVAIKPS
AEPSLVPWAL SGKSPEALRA QAARLRDFLA ERPEPRSIDI GHSLAVTRSQ FDHRAIVLVD
DAKAPADSLA ALAALASGVA DPAVVSDAVS TGGSAVLFTG QGAQRLGMGR ELYGRFPVFA
EALDVVVDHL DAALPAQAGL REVMWGDDVE LLNETGWTQP ALFAVEVALF RLVERWGVRP
DFVAGHSIGE IAAAHVAGVF SLEDACRLVA ARATLMQALP TGGAMIAVQA TEDEVTPHLT
DEVAIAAVNG PTSVVISGAE EATQTVAQHF ADQGRRTTAL RVSHAFHSPL MDPMLAEFRA
VAEGLSYATP SLPVVSNLTG WLATADELCS AEYWVRHVRE AVRFADGITT LEAEGVRTFL
ELGPDGILSA LAQQSLAGEA VTVPVLRKDR GEESTALTAR AHLHTRGLIE DWQDFFAGVG
AGRVELPTYA FQRGWFWPVG RVGVGGDVGA VGLGSAGHPL LGAAVELAAG AGVVLTGRLS
LSSHGWLADH AVMGRVFAPG TALLEMVMRA GDEVGCGRVE ELTLAAPLVL PERGGVRVQV
AVDAPDAAGR RGVGVYSCPD GVGQAVWSQH AVGVLASGAA DQVGGFGDGG VWPPQGAVSV
DAEGCYELFA DAGFGYGPVF QGLRAVWRRG EELFAEVALS DEVAESADTA TGFGLHPALL
DASLHASLLS SLEGQSADGG PALPFAWEGV SLFASGATAL RVRLAPAGEH AVSVTAVDPT
GAPVISIDAL RTRRLTLDEV NASHTQLSDA LFGVQWTTVP STPAADHPSV AIIGTDPFGL
ADGLSDALPL VEERGDLAAL AASEHPVPDL VLVPVAGTRR TGVPADAEGH TDAGTSDMLR
SVREATAQVL EQIQQWLADD RFEAARLVFV TRGAVSVGEG GIADLAASAV WGLVRSAQSE
NPGCFGLLDL DLDLALDSDL APEVDIERDR DRDPVGGTVQ PALAAALHAT ADEPQLALRG
GTVQAARLTR IPAPQTDRAE TDPAETDRPE IDTRRPGTVL ITGGTGGLGG LLARHLVAER
GVRSLVLASR SGLAAEGAEK LVADLEALGA VVAVQTCDVA DGDAVAALVA GVSDEYPLTA
VVHTAGVLDD GVIGSLTEER LATVLRPKAD AAWHLHEATR DLDLDAFVVF SSLAGVLGGA
GQANYAAANT FLDALMAQRR AAGLPGVSLA WGPWDRAGGM TGTLSDAEAD RLARSGVPPI
SAEQGLALYD AATAGERPLV VPVRLDLAAL RGLGDVPALL RGLVRTPARR TAAAGAAPSA
DVLTRQLAGL GGAEQEEVLL RLVRGQAAVV LGHADGSAIG AGRQFQELGF DSLTAVEFRN
RLNAATGLRL PATLLFDYPT PADVVGHLRG RLGTGEVSGA GSVLAALDNL EAVIAGLSLD
DAGEHQLVAG RLEVLRAKWA DMRSAEGAVD GGADVDIEEA SDDDMFALLD DELGLN
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