ID   Q9RNB0_MICAE            Unreviewed;      2126 AA.
AC   Q9RNB0;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   19-JAN-2010, entry version 46.
DE   SubName: Full=McyB;
GN   Name=mcyB;
OS   Microcystis aeruginosa PCC 7806.
OC   Bacteria; Cyanobacteria; Chroococcales; Microcystis.
OX   NCBI_TaxID=267872;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PCC7806;
RX   MEDLINE=20491409; PubMed=11033079; DOI=10.1016/S1074-5521(00)00021-1;
RA   Tillett D., Dittmann E., Erhard M., von Dohren H., Borner T.,
RA   Neilan B.A.;
RT   "Structural organization of microcystin biosynthesis in Microcystis
RT   aeruginosa PCC7806: an integrated peptide-polyketide synthetase
RT   system.";
RL   Chem. Biol. 7:753-764(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PCC7806;
RX   PubMed=15528494; DOI=10.1128/AEM.70.11.6370-6378.2004;
RA   Pearson L.A., Hisbergues M., Borner T., Dittmann E., Neilan B.A.;
RT   "Inactivation of an ABC transporter gene, mcyH, results in loss of
RT   microcystin production in the cyanobacterium Microcystis aeruginosa
RT   PCC 7806.";
RL   Appl. Environ. Microbiol. 70:6370-6378(2004).
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DR   EMBL; AF183408; AAF00961.1; -; Genomic_DNA.
DR   HSSP; O30409; 1DNY.
DR   SMR; Q9RNB0; 10-449, 451-965, 970-1495, 1519-2039, 2052-2124.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR006163; Phsphopanteth_bd.
DR   InterPro; IPR006162; PPantetheine_attach_site.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF00668; Condensation; 2.
DR   Pfam; PF00550; PP-binding; 2.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 2.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine.
SQ   SEQUENCE   2126 AA;  242352 MW;  57031CDA6A1A45B3 CRC64;
     MADTKNQPAK NVESIYPLSP MQEGMLFHSL YTPDSGIYCS QTLITLEGEI NLTVFRQAWE
     KVVERHSVLR TLFLWEKREK PLQIVRKKVD LPWDYQDWRN LSPTEQQQRL DLLLQTERQQ
     GFEFKVAPLM RCLMIQLSDQ TYKFLCNHHH IILDGWSMPI IYQEVLGFYE AGIQGKSHHL
     PSPRPYQDYI VWLQEQNPSV AESYWQRTLE GFMTPTPLRV DRLQLMKSEG KPTYKEYNCH
     LSASLSKDLQ SLAQKHNLTL STLVQAAWAI LLSRYSGESE VLFGVTVSGR PHDLSGVERR
     VGLFINTLPL RVSIRESDLL LSWLQELQQK QAEIQDYAYV SLAEIQRLSD IPPGVPLFES
     LVVFENYPRE ALSRDSRQSL RVKDVENFEE TNYPLTVVAI PRQELLIQLI YDTSRFTQDT
     IERMAGHLQT ILTGIVTDPR QRVTQLPILT TQEQHQLLVE WNNREADYPL DKSLHQLFEE
     QAAQNPQGIA VIFEDQKLTY QQLNNRGNQL AHCLRDKGVG PESLVGIFME RSLEMVIGLL
     GILKAGGAYV PLDPDYPTER LGDILSDSGV SLVLTQESLG DFLPQTGAES LCLDRDWEKI
     ATYSPENHFN LTTPENLAYV IYTSGSTGKP KGVLISHRGL MNLICWHQDA FEITPLDKIT
     QLARIAFDAA VWELWPCLTA GASLVLVKPE IMQSPPDLRD WLIAQEITVS FLPTPLVEKI
     LSLEWDENIA LRIILTGGDK LHHYPSGLMP FKLINNYGPT ENSVVTTSGL VRDYEEGNPP
     SPSIGKPVYN TKIYILDQNL QPLPIGVPGE LHISSVGLAR GYLNRLELTQ EKFISNPFNS
     GILYKTGDLV RYLPEGNIEF LGRIDNQVKL RGLRIELGEI EAVLETHSEV EKAVVILRED
     TSDNQRLVAY IVRKSPSLGI GELRRFLQQQ LPAYMVPSAF VILSDFPLNN NGKIDRKKLP
     VPDETSIIES AYIAPRNEKE SLLAQIWQDV LQVSKIGVSD NFFELGGHSL KAISLVSKIQ
     EKLGQSLPIK QVFAHPTIAE QAVLLSTVTP LTVATIPLVS TQETYETSHA QRRFYVLQQM
     DLNNVAYHIV STLKIAGDFS PDVFEKAIQL LISRHESLRT SFILINGEPQ QKILQNRPFD
     WEFKDWTNKP DEEILETIAK ERKAFDLEKS PLVRSKIYKL SPNEYILELE IHHIICDGWS
     MSLLAKECLQ YYSDLAKGLQ PNIEPLPIQY KDYAGWQNNL LRSENNSKTL DYWREKLDNG
     QLTRVHLPTD FKRPQIKTFK GSHLSWKFTQ ETISKLRKSC QENEITLFMA LVAAVKILLY
     RYSGQHDITI GTEIATRNHP QLQSLIGLFL NTLVIRDQIE PEKGYKNLLA KVRQTVTEAL
     EHSDYPFDIL VEKLAVSREI NRTPLFDTLV LLQNFEQSVG LENIQIKSLD SLTPTSKFDL
     SFVFSEDEEK LRLELIYNTD LFQEERMKKC LIHFDKLLNE MLSNPAQPVK DISLLSEAET
     AFIANFINPI PRLETRTVIH DFIDQVEATP EKTSIIYPGG KFSYQELHEL TNFWAYALKE
     LGVEKDKVCG VLLEGDYRQL IAMLAVFKAG GIYLPLRLDE PEERRQRMMI KTSPEIILVA
     AENLEGIKPQ LSALEKPPHI LVVKAHKIQQ YHQWNGMDYQ EFPCQLSKLQ PLLAMPDADD
     SNYIMFTSGS TGEPKAILGS HGSLRHFIDW EKREFGINES WRCLQIAQIN FDAYLRETCV
     TLCSGGTLYI PESTEREDLE LLLLRIGEWD INLLHTVPSV MRLFLKIGRG LVNAHNLLKS
     LRIFVLGGEP LFVKELAEWH QIFSSQTEFV NIYGASETTF VKHFYRIPNP NNIPYERVPG
     GQTLPDAAYA VVDGNRARAI GEVGEVFVKS PYLTKGYYQD ESLTHSVFVP NPLNGGRDIV
     YRTGDLGRLL PDLTLEVIGR SDNQIKLNGV RIELGEIEDV LSGIEGVEKA LVMANKKEEL
     VTVIAYYQAE DTVHQEYIRG KLKQLLPIYM QPSFLMRLEA FPLLPNGKIH RLALPKPEEN
     ITNSTNQVPD FNPQEALLAS LWGELLEAEV SNSNQSFFEL GGNSLKAMRL VSQIRNQFGV
     SLRLREIFTH NTLKEQAVLI QSRQKR
//