ID   Q9RNB1_MICAE            Unreviewed;      2795 AA.
AC   Q9RNB1;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   03-NOV-2009, entry version 48.
DE   SubName: Full=McyA;
GN   Name=mcyA;
OS   Microcystis aeruginosa PCC 7806.
OC   Bacteria; Cyanobacteria; Chroococcales; Microcystis.
OX   NCBI_TaxID=267872;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PCC7806;
RX   MEDLINE=20491409; PubMed=11033079; DOI=10.1016/S1074-5521(00)00021-1;
RA   Tillett D., Dittmann E., Erhard M., von Dohren H., Borner T.,
RA   Neilan B.A.;
RT   "Structural organization of microcystin biosynthesis in Microcystis
RT   aeruginosa PCC7806: an integrated peptide-polyketide synthetase
RT   system.";
RL   Chem. Biol. 7:753-764(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PCC7806;
RX   PubMed=15528494; DOI=10.1128/AEM.70.11.6370-6378.2004;
RA   Pearson L.A., Hisbergues M., Borner T., Dittmann E., Neilan B.A.;
RT   "Inactivation of an ABC transporter gene, mcyH, results in loss of
RT   microcystin production in the cyanobacterium Microcystis aeruginosa
RT   PCC 7806.";
RL   Appl. Environ. Microbiol. 70:6370-6378(2004).
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DR   EMBL; AF183408; AAF00960.1; -; Genomic_DNA.
DR   HSSP; P14687; 1AMU.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR006163; Phsphopanteth_bd.
DR   InterPro; IPR006162; PPantetheine_attach_site.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF00668; Condensation; 2.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   Pfam; PF00550; PP-binding; 2.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 2.
DR   TIGRFAMs; TIGR01720; NRPS-para261; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 2.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Phosphopantetheine.
SQ   SEQUENCE   2795 AA;  315610 MW;  FE871F8E872A426A CRC64;
     MEAHLVSIDY QIRQLQEIDP VTTLFGNVSQ NKTGEQHSVL EVISTDLQEK INSLTANNSV
     NNLAFHLAVV QVLMFKYTAQ VEFATATAAL NTKKLDSLIF CRFNQHNFSS FKDLLRIIRK
     DLQEGYRHQN YALDSLVKTL AARGGNLENI FDVAVIKEGL CADISSLNRF QLVFTIEADD
     SGVSVTFIKD KFPRDFVERM LGHYLEILEM VTSNPDIDLS EIDILTTEER EQLLRDWNDT
     AIEYPEKQWI HQLFEEQAKL YPERGAVIFE NQELTYQELN EKANQLGHYL QKLGVKPEEL
     VGIYLERSLE MVVGLLAVLK AGGAYVPLDP NYPQERLSYL LEDTGVKVII TGESLRGLLD
     EYRGIVVALD TDWSAISQES QNNCDSGVTG ENLAYVIYTS GSTGKPKGVM NNHKGIRNRL
     LWMQDTYQLT KSDCILQKTP FSFDVSVWEF FWPLLAGATL VVAEPEGHKD STYLIQLIQK
     QQITTLHFVP SMLRVFLQEP ELKGCSSLKR VFCSGEALSL ELTQRFFEHF DCELHNLYGP
     TEAAIDVTYW PCLPESQKAI VSIGRPIANT QIYILNPHLQ PVPIGIVGEL HIGGIGLARG
     YLNRPELTAE KFIPNPFAKV EAGIGGEIRA KLYKTGDLAR YLPDGNIEFL GRIDHQVKIR
     GFRIELGEIE AILSQHPAVE QAVVIASETE TGSQTLIAYV VGQSQEGELL TTSENGQLFD
     EQIGQWQSLY NQIYSQTSAD SQGIFNIVGW NSSYTGEPIP AAQMREWLDD KVKVILAQKP
     KKVLEIGCGT GLILFQVAPH CQCYWGTDIS SVALDHIQRI NQEGPKLEQV RLLHSTADKF
     EGLESEGFDT IILNSVVQYF PHIDYLLRVL EGAIKVLTPG GCIFLGDVRN LQLMEAFHAD
     VELYKANPED SIKDFKQRVQ RKIEQENELF IDPDFFRAIQ SYFPQITEVE IHLERGQHHN
     ELTQFRYNVV LRSATILDFS TDFPELNWTE QQLTLSEVRN QLGTSEGLRV IGVPNSRLFR
     PLKSVELFRN SQDFGTTEEF QAIKSEIIPE NAVEPEDFSA LAEDLSLSVW VTWSDTPDRY
     DVIFAPLENS QRNYIAFTPT HTVKPEGQLY ANHPLRSKLN SKLIPQLRSY LQKQLPEYMI
     PHAFVQLDSI PLTNNGKIDR RALPSPSYNS LRNSENFVAP CTPLEEILAL IWAEVLGIEE
     VGIHDNFFEL GGDSIRAIQV IAKARQMGFH FSLPQLLQHQ TIQELANCVS YEIDTLGTEK
     TEVFSLISQE VRLNLPEEVE DAYPLTALQL GMIFHSEYQG NLSVYHDVFT YHIRADFSFP
     ALHSAIQEIV QRHPVLRTSF ALFEYQEPLQ LVHRQIDVPL GLDDLTHLST SEQDTAIDDW
     IEREKIRTFD WNIPPLFRFH LHRRSQDNFN LTFSFHHSIL DGWSVASLLT ELLQQYLYLL
     DKKVLPLSPT PALSFRDFVA LEKKTIQSPE CQNYWQEKLR DVTLTKLPQW SKSNQVNQDW
     DWLVPISSQV SQGLKQLGKQ VGVPLKSVLL AAHFRVLSLL NNQRDIVTGL VSNGRLEAAD
     GEKILGLFLN TLPLRLELSG GPWSDLVKQA FDVERECLSW RRYPLAELQK SGQPLFDTAF
     NFIHFHVYQG IIGVKDLEVL GGKFFNQTNF TLLANFSLHP LSSQIELTLK YDGNYLGEKQ
     MELIGGYYEK TLIAMATEGL ERYETCCLLS EQEQHQLLKE WNDTEVHYPD GCIHQLFEEQ
     VKRSPDAIAI ITENEQLTYR QLNEKANQLG RYLARKGVKF ESLVGICLER TPEMVIGLLA
     ILKAGGAYVP LDPAYPTERL NVILEDAQVS LLLTQAKLVE KLGNYPGNLV ILEAEQKNIA
     LESPENLSLP VSSSNTAYVI YTSGSTGKPK GVVIEHHSTT TLLNWSKEVF SSEELAGVLG
     STSICFDLSV FELFLPLAVG GKIILAQNVL DLPSLSAAKE VTLINTVPTA IAQLLEIEAI
     PETVRTVNLA GEALSNQLVQ KLYQQENIKN VYNLYGPSED TTYSTFSLVP KGHHGQPSIG
     RPIANTQVYI LDSFKQPVPL GTIGDLYIGG EGLARCYLNQ PELTAEKFIS NPFSNEPNAK
     LYKTGDLARY LPDGNIDFLG RGDNQVKLRG FRIELGEIEA TLGTYPPVKQ AVVKVWEDSY
     RNKRLVAYLV AENDPINTED LRRFLGQKLP EYMIPALFVS LEALPLTPNG KIDRSRLPIP
     EIPSTSEQDF VPPHTQKEKI LASIWQDILS IKQVSRYDRF FEVGGDSIIS IQVVARARQA
     GLKITPKQIF EYPTLAELAT VADYSTAELA KQGLVTGIVP LTPIQLWFFE QNRAEMHHFN
     QSVLLEVPHH LKADLLAQSL RKLIEHHDAL RLRFTVEEGQ WQQVNGGMPD EVPFEVIDLS
     SIPQSQQGET LLAMATTQQA SLNLSSGLLI KAVLFELAPY QPSRLLIIIH HLGVDGVSWR
     ILLEDLLMTY QQLERGENVE LPPKTIAFQD WALLLRDYSS APLTNHGQGE KAREPLDYWL
     TQPWLEASNL PVDDETGKPY NTVATANDVT VTLDEEQTRA LLQKVPAAYN TQINEVLLTA
     LAETLTQWTE NLTISLDLEG HGREDLFSEV DLSRTVGWFT SLFPVILRLP PENHPGERLK
     SIKEQLRAIP HRGIGYGISR YLSDDADIKS QLAEIPAREV LFNYLGQFEQ GRLQKGEWKL
     ADESKGPNHS LKGHRSHLLE ITARVIEGQL QVNWTYSHLI YERSTVEYLG RSYKEALLKL
     IEHCLSPDAG GYTPSDFPVA HLNQQELDDI LAEID
//