ID   RIFF_AMYMD              Reviewed;         260 AA.
AC   O52547;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   19-JAN-2010, entry version 43.
DE   RecName: Full=3-amino-5-hydroxybenzoic acid synthase;
DE            Short=AHBA synthase;
DE            EC=2.3.1.-;
DE   AltName: Full=Rifamycin amide synthase;
GN   Name=rifF;
OS   Amycolatopsis mediterranei (Nocardia mediterranei).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Pseudonocardineae; Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=33910;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=S699;
RX   MEDLINE=98165773; PubMed=9497318; DOI=10.1074/jbc.273.11.6030;
RA   Kim C.G., Yu T.W., Fryhle C.B., Handa S., Floss H.G.;
RT   "3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the
RT   formation of the precursor of mC7N units in rifamycin and related
RT   antibiotics.";
RL   J. Biol. Chem. 273:6030-6040(1998).
CC   -!- FUNCTION: Putatively terminates polyketide biosynthesis by
CC       transfer of polyketide acyl chain to the secondary amine on the 3-
CC       AHBA starter unit.
CC   -!- SIMILARITY: Belongs to the arylamine N-acetyltransferase family.
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DR   EMBL; AF040570; AAC01715.1; -; Genomic_DNA.
DR   SMR; O52547; 4-254.
DR   BioCyc; MetaCyc:MONOMER-14108; -.
DR   GO; GO:0016407; F:acetyltransferase activity; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR001447; N-AcTrfase.
DR   PANTHER; PTHR11786; Acetyltransf2; 1.
DR   Pfam; PF00797; Acetyltransf_2; 1.
DR   PRINTS; PR01543; ANATRNSFRASE.
PE   3: Inferred from homology;
KW   Acyltransferase; Transferase.
FT   CHAIN         1    260       3-amino-5-hydroxybenzoic acid synthase.
FT                                /FTId=PRO_0000107920.
FT   ACT_SITE     73     73       Acyl-thioester intermediate (By
FT                                similarity).
FT   ACT_SITE    111    111       By similarity.
FT   ACT_SITE    126    126       By similarity.
SQ   SEQUENCE   260 AA;  29192 MW;  C32605EBC0BFBF47 CRC64;
     MNVFDVETYL QRIGCGGETG VDLETLAKLQ KSHLMAIPYS SLAYELRDAV NVVDLDEDDV
     FVTSIAEGQG GACYHLNRLF HRLLTELGYD VTPLAGSTAE GRETFGTDVE HMFNLVTLDG
     ADWLVDVGYP GPTYVEPLAV SPAVQTQYGS QFRLVEQETG YALQRRGAVT RWSVVYTFTT
     QPRQWSDWKE LEDNFRALVG DTTRTDTQET LCGRAFANGQ VFLRQRRYLT VENGREQVRT
     ITDDDEFRAL VSRVLSGDHG
//