ID   TCMP_STRGA              Reviewed;         270 AA.
AC   P39887;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   19-JAN-2010, entry version 37.
DE   RecName: Full=Tetracenomycin polyketide synthesis O-methyltransferase tcmP;
DE            EC=2.1.1.-;
GN   Name=tcmP;
OS   Streptomyces glaucescens.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 40716 / ETH 22794 / GLA.0;
RX   MEDLINE=93286001; PubMed=8509339;
RA   Decker H., Motamedi H., Hutchinson C.R.;
RT   "Nucleotide sequences and heterologous expression of tcmG and tcmP,
RT   biosynthetic genes for tetracenomycin C in Streptomyces glaucescens.";
RL   J. Bacteriol. 175:3876-3886(1993).
CC   -!- FUNCTION: O-methyltransferase that catalyzes the methylation of
CC       the C-9 carboxy group of tetracenomycin E (TCM E) to yield TCM A2.
CC       Catalyzes as well the following side reactions: methylation of 8-
CC       O-methyl-TCM D3 to 9-carboxymethyl-8-O-methyl-TCM D3; and of TCM
CC       B3 to 9-carboxymethyl-TCM B3.
CC   -!- PATHWAY: Antibiotic biosynthesis; tetracenomycin C biosynthesis.
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DR   EMBL; M80674; AAA67510.1; ALT_INIT; Genomic_DNA.
DR   PIR; S27688; C47127.
DR   SMR; P39887; 7-188, 63-222.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR007213; LCM_MeTrfase.
DR   InterPro; IPR016874; Polyketide_Synt_OMeTrfase_TcmP.
DR   Pfam; PF04072; LCM; 1.
DR   PIRSF; PIRSF028177; Polyketide_synth_Omtfrase_TcmP; 1.
PE   4: Predicted;
KW   Antibiotic biosynthesis; Methyltransferase; Transferase.
FT   CHAIN         1    270       Tetracenomycin polyketide synthesis O-
FT                                methyltransferase tcmP.
FT                                /FTId=PRO_0000072458.
SQ   SEQUENCE   270 AA;  30886 MW;  53D14779B2265F83 CRC64;
     MGETIRLTGV HETLLATLQA RALDNRQPRP VLGDATAEEL LRRIDYDFSR IRTATKDMRI
     VTFRARKLDE WAGRFLAVHP DAVVLHLACG LDSRAFRMDV PDTVEWIDVD VPDVIELRSR
     LYPERDGYRM IGASVTTEDW LDTVPRNRPA LVVAEGLTPY LREADGEEML RRVIRHLPTG
     AVMFDAVLPW TLRFAKYSQL LRATGATFGW GIGNPRSLES RVPGLRFQEQ WSMLDSPFLA
     DARPVEKWVG AGMRSIPQLR FAHRLLRYTF
//