KEGG   Xenopus laevis (African clawed frog): 373725
Entry
373725            CDS       T01010                                 
Symbol
cftr.L
Name
(RefSeq) cystic fibrosis transmembrane conductance regulator isoform X1
  KO
K05031  cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6]
Organism
xla  Xenopus laevis (African clawed frog)
Pathway
xla02010  ABC transporters
xla04530  Tight junction
Brite
KEGG Orthology (KO) [BR:xla00001]
 09130 Environmental Information Processing
  09131 Membrane transport
   02010 ABC transporters
    373725 (cftr.L)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    373725 (cftr.L)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:xla02000]
    373725 (cftr.L)
Enzymes [BR:xla01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.1  Enzymes altering polypeptide conformation or assembly
    5.6.1.6  channel-conductance-controlling ATPase
     373725 (cftr.L)
Transporters [BR:xla02000]
 ABC transporters, eukaryotic type
  ABCC (CFTR/MRP) subfamily
   ABCC7 subgroup
    373725 (cftr.L)
SSDB
Motif
Pfam: ABC_membrane CFTR_R ABC_tran SMC_N AAA_21 AAA_29 AAA_16 RsgA_GTPase nSTAND3 T2SSE DUF87 MMR_HSR1 MeaB Zeta_toxin NTPase_1 AAA_23
Other DBs
NCBI-GeneID: 373725
NCBI-ProteinID: XP_018108050
Xenbase: XB-GENE-866530
UniProt: A0A1L8GYY2 A0A974HSU1
Position
3L:75128155..75202388
AA seq 1485 aa
MQRSPLEKASIFSQIFFSWTKPILWKGYRQRLELSDIYQIHPGDSADNLSERLEREWDRE
VATSKKNPKLINALKRCFFWKFLFYGILLYLGEVTKAVQPLLLGRIIASYDRDNEHERSI
AYYLAIGLCLLFVVRMLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSKVLDKISTGQ
LVSLLSNNLNKFDEGLALAHFVWIAPLQVLLLMGLLWDLLQASAFCGLGFLIILALFQAW
LGRMMMKYRDKRAGKINERLVITSEIIENIQSVKAYCWENAMEKIIETIRETELKLTRKA
AYVRYFNSSAFFFSGFFVVFLSIVPHLLLDGISLRKIFTTISFSIVLRMAVTRQFPWAVQ
TWYDSLGVINKIQEFLQKEEYKSLEYNLTTTEVAMENVSASWDEGIGEFFEKAKLEVNGG
NISNEDPSAFFSNFSLHVAPVLRNINFKIEKGQLLAIAGSTGAGKTSLLMMIMGELEPSA
GKIKHSGRISFSPQVSWIMPGTIKENIVFGVSYDQYRYLSVIKACQLEEDISKFPEKDNT
VLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFSYLDLFTEKEIFESCVCKLMANKT
RILVTSKVEQLKKADKVLILHEGSCYFYGTFSELQDQRPEFSSHLIGFDHFNAERRNSII
TETLRRCSIDSDPTGVRNEVKNKSFKQVADFSEKRKNSIINPRKSSRKFSVMQKSQPQMS
GIEEEDVPAVQGERKLSLVPESEQGEASLPRSNIFNTGPTFQGRRRQSVLNLMTRTSISQ
GSNAFATRKTSVRKMSVSSYSNSSFEVDIYNRRLSQDSILEVSEDINEEDLKECFLDDTD
SPSTTTTWNTYLRFLTAHKNFIFILVFCIVIFLAEVVASSAGLWVLKSNAPVSNTTSNGN
GSEISDTLSVIVTHTSFYYVFYIYVGVADSLLALGIFRGLPLVHSLISVSKVLHKKMLHA
ILHAPMSTFNTMRAGRILNRFSKDTAILDDILPLSIFDLTQLVLIVIGAITVVSLLEPYI
FLATVPVIVAFILLRSYFLHTSQQLKQLESEARSPIFAHLITSLKGLWTLRAFGRQPYFE
TLFHKALNLHTANWFLYLSTLRWFQMTIEMIFVIFFIAVSFISIATSGAGEEKVGIVLTL
AMNIMNTLQWAVNASIDVDSLMRSVSRIFRFIDLPVEELINENKNKEEQLSEVLIYENDY
IKKTQVWPSGGQMTVKNLSANYIDGGNTVLENISFSLSPGQRVGLLGRTGSGKSTLLSAF
LRLLSTQGDIQIDGVSWQTIPLQKWRKAFGVIPQKVFIFSGSIRKNLDPYGKWSDEELLK
VTEEVGLKLIIDQFPGQLDFVLLDGGCVLSHGHKQLVCLARSVLSKAKILLLDEPSAHLD
PITFQIIRKTLKHAFADCTVILSEHRLEAMLECQRFLVIEDNTVRQYDSIQKLMNEKSFF
KQAISHSDRLKLFPLHRRNSSKRKSRPQISALQEETEEEVQETRL
NT seq 4458 nt   +upstreamnt  +downstreamnt
atgcagagatccccactggagaaagccagcattttttcacagattttctttagctggact
aagccaattttgtggaaaggctataggcaacgtctggaattatcagacatttaccagatt
cacccaggggactctgcagataacctttcagaaaggctagaaagagaatgggacagggag
gtggcaacatcgaagaaaaaccccaaattaattaatgcactgaaacgatgttttttctgg
aaatttctcttctatggtatcttattatacctgggggaagtaactaaagctgttcaacct
cttcttcttggaagaatcattgcctcttatgaccgtgacaatgagcatgaacgatcgatt
gcttattacctggcaattggtctatgtctactcttcgtagtcaggatgcttcttttacat
cctgccatttttggcctacaccatatcggaatgcaaatgagaatagcaatgtttagtcta
atttacaaaaagactttaaaactttcaagcaaagttctcgataaaattagcactggacaa
cttgtgagtcttctatcaaataacctcaataaatttgatgagggactcgctctggctcat
tttgtttggattgcacctttgcaagtactgctgttgatgggactgctatgggacttactc
caggcctcagcattttgtgggcttggctttcttatcatccttgcattgttccaagcatgg
cttggtcgtatgatgatgaaatatagggataagagggcagggaagatcaatgaacgactt
gtgataacatctgaaatcatagagaacatccagtctgtaaaggcctactgttgggagaat
gcgatggaaaaaataattgaaaccataagagagactgaactgaagcttactcgaaaagct
gcatatgtgcgatacttcaacagctcagccttcttcttctctggattttttgtggtgttt
ctttctattgtacctcatctgttactcgatggcatttcactccgaaaaatatttactacc
atttcatttagcatagtcctgcgaatggcagtaactaggcagtttccctgggctgtacag
acatggtatgactctcttggagtgataaataaaatacaggaattcttacaaaaggaagaa
tataaatcattggaatataatttgacaaccacagaagttgccatggaaaatgtttcggca
tcatgggatgaggggattggagaattctttgaaaaagcaaagctagaagtaaatggaggg
aatatttctaatgaggatccaagtgcattcttcagtaacttttccctgcatgttgctcca
gtcctcagaaacattaattttaagattgaaaaaggacagcttttagcaattgctggatct
acaggggctggaaagacttccctattgatgatgatcatgggagaactggagccatcagct
ggtaaaataaagcatagtggaaggatatcattttctcctcaagtatcttggatcatgcca
gggaccatcaaagagaatatagtgtttggcgtttcctatgaccaatacagatacctgagt
gttataaaagcctgtcagctggaagaggacatctcaaaattcccagaaaaagataatact
gtgctaggggaagggggaataacattaagtggaggacagcgtgcaaggatttcacttgca
agagctgtgtacaaagatgctgacctctacttgctggattctccattcagttatttagac
ttgtttacagaaaaagaaatatttgaaagttgtgtttgcaagctaatggccaataaaaca
aggattttagttacatctaaagtcgaacagcttaaaaaagctgacaaagtgcttattttg
cacgaaggaagctgttatttctatggaacattttctgaacttcaagatcagcgtcctgaa
ttcagctctcatctgattggatttgatcacttcaatgcagaaagaagaaactctataata
actgaaaccctgagacgatgctccattgatagtgatccaacaggggttagaaatgaagta
aaaaataagtcatttaagcaggttgcggatttcagtgaaaaaagaaagaactctattatt
aatcctcgaaaatcaagcagaaaattttctgtcatgcagaaaagtcagccacagatgagt
ggaatagaagaggaagatgtgccggcagtgcaaggagaacgaaaactctccttagttcct
gaatccgaacaaggagaagccagcttgccaagaagcaacatttttaatacaggtcctaca
tttcaaggccgcaggagacagtctgtgttaaatctaatgactcgcacctccatttcacaa
ggttccaatgcctttgcaacaagaaaaacatctgttcgtaaaatgtctgtaagctcttat
tccaactcatcatttgaagtggatatatataatagacgactttcacaagacagtatttta
gaagttagtgaagatattaatgaagaagatttgaaggaatgtttcctggatgatacagac
agcccatcaacaaccaccacatggaacacgtatctaagatttcttacagctcacaaaaat
ttcatttttattcttgtattttgcatagtgatatttttagctgaggtagttgcttcatca
gctgggctctgggttcttaagagtaatgctcctgttagcaacacgaccagtaatgggaat
ggatctgaaatatcggacaccctttctgttattgtaacacacactagtttttactatgtg
ttttacatttacgtcggagtggctgactccttactggctctgggaatattcagaggtttg
cctctggtacacagtcttatatcagtttccaaagtgttacacaagaaaatgttgcatgct
attctacatgccccaatgtcaaccttcaatacaatgagagctggtcggatacttaacaga
ttttcaaaggatacagctatattggatgacattctacctctgtcaatatttgacttaact
cagcttgttcttattgtgattggagcaataacagtggtttcattacttgaaccttacatt
ttcctggctacagttcctgtaattgttgcttttattctcttgagatcatactttcttcac
acatctcagcaacttaaacaattagagtctgaagcccgcagtccaatttttgctcacctc
ataacaagtttaaaaggtttatggacattaagagcctttgggagacagccatattttgaa
accctttttcacaaagcactgaatttacatactgcaaactggtttctctatctctctacc
ctacgctggttccaaatgacaatagaaatgatttttgtgatattcttcatcgctgtttca
ttcatctccattgcaacttcaggtgctggggaagaaaaagttggaattgttttaacattg
gcaatgaatatcatgaacacattacagtgggctgtaaacgctagcattgatgtggacagc
ttgatgcgttctgtcagcagaatttttcggttcattgatcttccagtagaagagttgata
aatgaaaataaaaacaaagaggagcaactttcagaggtcctgatatatgagaatgattac
atcaagaaaactcaagtctggccatctggaggtcagatgacagtgaaaaacctttctgca
aattatatagatggaggaaacactgtgttagaaaatatctccttctcattaagccctgga
caaagggttggcttattaggcagaactggttcaggcaaaagcaccctgttgtctgccttt
ttgagattattatcaacccaaggagacattcagattgatggggtatcctggcagaccatt
ccacttcagaaatggagaaaggcatttggagtgattccacagaaagtattcatattttct
gggtccattcgaaaaaatcttgacccctatggaaaatggagtgatgaggaactcttgaaa
gtcacagaagaggttggtttaaagttgataattgatcagtttccaggacaattggatttt
gtgcttctggatgggggttgtgttcttagccacggccacaagcaactcgtatgtttggcc
aggtctgttctcagcaaagccaaaatcttactactcgatgagcctagtgcacatttggat
ccaataaccttccaaataattaggaaaacactgaaacatgcatttgcagattgcacagta
attttgtcagaacacagactagaggcaatgttggaatgccagcgctttctggtgattgaa
gacaatacagtacgacagtatgattctattcaaaagcttatgaatgagaagagtttcttc
aaacaagccataagtcattctgatcgcttgaaactattcccattacatcgtagaaattcg
agcaaacgaaaatccagaccccaaatttctgccttacaagaagaaacagaagaggaggtc
caggaaacaagactctaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (21)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
   XENBASE (1)   
Protein sequence (4)   
   UniProt (2)   
   RefSeq(pep) (2)   
DNA sequence (6)   
   RefSeq(nuc) (2)   
   GenBank (2)   
   EMBL (2)   
Protein domain (16)   
   Pfam (16)   
All databases (59)   

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