KEGG   Xenopus laevis (African clawed frog): 379991Help
Entry
379991            CDS       T01010                                 

Gene name
map2k1, mek-2
Definition
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)
Orthology
K04368  
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
xla  Xenopus laevis (African clawed frog)
Pathway
MAPK signaling pathway
ErbB signaling pathway
FoxO signaling pathway
Oocyte meiosis
Vascular smooth muscle contraction
Dorso-ventral axis formation
VEGF signaling pathway
Focal adhesion
Gap junction
Toll-like receptor signaling pathway
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Melanogenesis
Brite
KEGG Orthology (KO) [BR:xla00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    379991 (map2k1)
   04012 ErbB signaling pathway
    379991 (map2k1)
   04370 VEGF signaling pathway
    379991 (map2k1)
   04068 FoxO signaling pathway
    379991 (map2k1)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    379991 (map2k1)
  Cell growth and death
   04114 Oocyte meiosis
    379991 (map2k1)
  Cellular commiunity
   04510 Focal adhesion
    379991 (map2k1)
   04540 Gap junction
    379991 (map2k1)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    379991 (map2k1)
  Endocrine system
   04910 Insulin signaling pathway
    379991 (map2k1)
   04912 GnRH signaling pathway
    379991 (map2k1)
   04914 Progesterone-mediated oocyte maturation
    379991 (map2k1)
   04916 Melanogenesis
    379991 (map2k1)
  Circulatory system
   04270 Vascular smooth muscle contraction
    379991 (map2k1)
  Development
   04320 Dorso-ventral axis formation
    379991 (map2k1)
Enzymes [BR:xla01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     379991 (map2k1)
Protein kinases [BR:xla01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   379991 (map2k1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Xenbase: 
UniProt: 
AA seq 395 aa AA seqDB search
MPKKKPTPIQLNPNPEGTAVNGTPTAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKVSELGAGNGGVVFKVSHKPTSLIMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGKIPEKILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAIGRYPIPPPDAKELELIFGCSVERDPASSELAPRPRPPGRPIS
SYGPDSRPPMAIFELLDYIVNEPPPKLPSGVFGAEFQDFVNKCLVKNPAERADLKQLMVH
SFIKQSELEEVDFAGWLCSTMGLKQPSTPTHAAGV
NT seq 1188 nt NT seq  +upstreamnt  +downstreamnt
atgcctaaaaagaagcctacgcccatacagctgaatcccaaccccgaagggactgctgtg
aacgggacccctacagccgagacaaaccttgaagctctgcagaaaaagttggaagagctt
gagctggatgagcagcagaggaagcgtctggaggcttttctcacccagaagcagaaagtt
ggggaactgaaggatgacgactttgaaaaagtttcagagcttggagcaggcaacggagga
gtggtgtttaaggtgtcccacaagccaaccagcttgattatggccaggaagttgattcat
ctggagattaagcctgcaatccgaaaccagattatccgagagttgcaggttctgcatgaa
tgtaactccccatacattgtggggttctatggggccttctacagtgatggagagatcagc
atttgcatggaacacatggatggaggctcccttgatcaggttctgaagaaagctggcaaa
atcccagaaaagattttgggaaaagtcagcattgcagtgataaaaggtctaacctacctg
agagaaaagcataagataatgcacagagatgtgaaaccttctaacatcctggtcaactct
agaggagagataaaactctgcgactttggggtcagcgggcaactcatagactccatggca
aattcctttgttgggacaagatcctatatgtcaccggagcgactacagggcactcattat
tctgtgcaatcagacatctggagcatggggctgtcgctggtggaaatggccattggaagg
tatcccattccaccccctgatgccaaagagctggaacttatctttgggtgttctgtagaa
agggatccagcatcttctgaactggcacctcgcccccggccacccggacgtccaataagc
tcatacggtcctgatagtcgaccacccatggctatttttgaacttctggattatatcgtg
aacgagccgcctccaaaattgcccagtggagtatttggagctgagttccaggactttgtg
aataaatgtcttgtgaagaatccggcagagagagcagaccttaaacagctaatggttcac
agcttcattaagcagtcagagttggaggaagtggattttgctggatggctctgttccact
atgggccttaagcagcccagtaccccaacccatgccgccggagtgtga

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