KEGG T00165: YP

Yersinia pestis 91001 (biovar Microtus): YP_0118

Entry

YP_0118 CDS T00165

Gene name

metL

Definition

bifunctional aspartate kinase II/homoserine dehydrogenase II (EC:1.1.1.13 2.7.2.4)

Orthology

K12525

bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:2.7.2.4 1.1.1.3]

Organism

ypm Yersinia pestis 91001 (biovar Microtus)

Pathway

ypm00260	Glycine, serine and threonine metabolism
ypm00270	Cysteine and methionine metabolism
ypm00300	Lysine biosynthesis
ypm01100	Metabolic pathways
ypm01110	Biosynthesis of secondary metabolites
ypm01120	Microbial metabolism in diverse environments
ypm01230	Biosynthesis of amino acids

Module

ypm_M00016	Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
ypm_M00017	Methionine biosynthesis, apartate => homoserine => methionine
ypm_M00018	Threonine biosynthesis, aspartate => homoserine => threonine

Class

Metabolism; Amino acid metabolism; Glycine, serine and threonine metabolism [PATH:ypm00260]
Metabolism; Amino acid metabolism; Cysteine and methionine metabolism [PATH:ypm00270]
Metabolism; Amino acid metabolism; Lysine biosynthesis [PATH:ypm00300]

SSDB

Motif

Pfam:

Homoserine_dh AA_kinase NAD_binding_3

Other DBs

NCBI-GI:

45439981

NCBI-GeneID:

2764319

UniProt:

Q7CL18

Position

124135..126570

AA seq 811 aa
MNATAVAAAATGRQLHKFGGSSLADVKCYLRVANIMANYSHPGDLMVVSAAGSTTNQLIS
WLKLSQNDRLSAHQVQQSLRRYQHDLINGLLPPEMAEPLISEFIHDLERLAGLLDNKIDD
VIYAEVVGHGEIWSARLMSALLNKLDMDAVWLDARRFLRAERAAQPQIDESRSYPLLQQL
MAQHPHQRLVVTGFISRNEAGETVLLGRNGSDYSATQVGALAGAERVTIWSDVAGVYSAD
PRKVKDACLLPLLRLDEASELARLAAPVLHTRTLQPVSGSDIDLQLRCSYQPEQGSTRIE
RVLASGLGAKIVTSHDDVCLIELQIASHHDFSLAQKEIDLLLKRAQIKPLATGIHPDRNL
LQLCYTSEVVNSALRVLEDAALPGKLSLREGLALVALVGAGVSKNPLHSHRFYQQLKDQP
VEFVWQAEDGISMVAVLRLGPTEHLIQGLHQSLFRAEKRIGLMLFGKGNIGARWLELFAR
EQKSLSARSGFEFVLAGVVDSRRSLLSYDGLDASRTLAFYNDEAKEQDEESLFLWMRAHP
FDDLVVLDVTASPSLAEQYLDFASYGFHVISANKLAGASSSNNYRQIRDAFAKTGRHWLY
NATVGAGLPVNHTVRDLRDSGDSILAISGIFSGTLSWLFLQFDGSVPFTELVDQAWQQGL
TEPDPRVDLSGQDVMRKLVILAREAGYDIEPNQVRVESLVPAGAESGSVDQFFENGEALN
QQMIQRLEAAKEMGLVLRYVARFDANGKARVGVEAVRTDHPLASLLPCDNVFAIESRWYR
DNPLVIRGPGAGRDVTAGAIQSDLNRLSQLL

NT seq 2436 nt +upstreamnt +downstreamnt
atgaatgcaacagcggtagcagcggcggcaacgggccgtcaactgcataaatttggtggc
agtagccttgcggatgtgaagtgttatctacgggtggctaatattatggccaactacagt
caccccggcgatctcatggtggtgtctgctgccgggagcacgacaaaccagttgatcagt
tggttgaaactcagtcaaaacgaccgtctttctgctcatcaggtacagcaaagtctgcgt
cgttatcaacacgatctgatcaatggcttattgcctccagaaatggcagagccattaatc
agtgagtttattcatgatttagagcgcctggcgggcttgctggataataaaattgatgat
gtgatttatgctgaagtggttggtcatggtgaaatttggtcagcccgcttgatgtctgcg
ctactgaataagttggatatggatgccgtctggcttgacgcccgccgtttcctacgtgca
gagcgtgcagcgcaaccacaaattgatgaaagccgctcttatccgttactgcaacaatta
atggcccaacaccctcaccagcgtttggtggtgactggttttatctcgcgcaatgaggcg
ggtgaaacggtcttgcttggccgtaatggcagtgactattcggcgacgcaggtcggggca
ttggccggggccgagcgtgtcaccatctggagtgatgttgccggggtgtacagtgccgat
ccacgtaaagtgaaggacgcttgcctgctaccattattgcggttggatgaagccagtgaa
ctggcccgcctggcagcaccggtgttacatacccgcacattacaaccggtttctggtagt
gacatcgatttgcaattacgttgcagttatcagccggagcaggggtcaacccgtattgaa
cgtgtgctggcttcgggattgggtgccaagatagtgaccagccacgatgatgtttgcctg
attgaattgcagattgccagtcaccatgatttctcgttggcgcagaaagagatcgatcta
ctgctcaaacgtgcgcaaatcaaaccactggcgaccggtattcacccagatcgtaacctg
ctgcaactttgctatacctcagaagtggttaacagcgccttacgggtgttggaagatgcc
gctctgccggggaaactctctctgcgcgaagggctggcattggtcgcactggtgggggcg
ggggtgagcaagaacccacttcacagtcaccgtttctaccaacaactgaaagatcagcca
gttgagtttgtctggcaggccgaagacggtatcagtatggtggccgtcctgcgtcttggg
ccgactgagcacctgattcaagggttgcaccagtcgttgttccgggcggaaaaacgtatt
ggtctgatgctgtttggcaaaggcaacattggtgctcgctggttggagctgtttgcccgt
gagcagaaaagtctttcggcccgcagtggttttgaatttgtgctagccggggtggtcgat
agccgccgtagtctgctgagttacgatggtttggatgccagccggacgctggcattttac
aacgatgaagccaaagaacaggatgaagaatccctgttcttgtggatgcgtgcccacccg
tttgacgacctggtggtgttggatgtgaccgccagcccgtcacttgcagaacaatatctg
gattttgccagttatggtttccacgttatcagcgcgaacaaattagcgggggcttcaagc
agcaataattaccgccaaatccgcgatgcgtttgcgaaaactggccgccactggttgtat
aacgccacggtaggcgcggggttaccggttaaccatacggtgcgcgatctgcgtgacagt
ggcgacagtattttagcgatcagcggtattttctctggcacgctgtcttggttattcctg
caatttgatggctcagtaccttttaccgagctggtagaccaagcctggcagcaaggtttg
accgagcctgatccaagggttgatctctctggtcaggatgtaatgcgtaagttggtgatt
ttagcccgtgaagcgggttacgacatcgaaccgaatcaggtgcgggtggagtcgttggtg
cctgctggcgcagagagtgggtcggttgatcaattctttgaaaacggcgaggcattaaat
cagcaaatgattcagcgtttagaagccgcgaaggagatgggcttggtattacgctacgtg
gcacgctttgatgctaatggtaaagcgcgggtgggcgttgaagcggtacgtaccgatcat
ccgttggcttctttgctaccgtgcgataatgtttttgctattgagagccgctggtatcgc
gataatccgttggtgattcgcggcccaggcgctggccgtgatgtgaccgctggggcgatt
caatctgatttaaaccgcctatcacaactgttgtaa

All links

Pathway (10)   
   KEGG PATHWAY (7)   
   KEGG MODULE (3)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (5)   
   KEGG ENZYME (2)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
Protein domain (3)   
   Pfam (3)   
All databases (36)   

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