| D00094 |
Tretinoin (JAN/USP/INN); Avita (TN); Renova (TN); Retin A (TN); Tretinoin (TN) |
(P) unclassified |
| D00105 |
Estradiol (JAN/USP/INN); Climara (TN); Divigel (TN); Estrace (TN); Estraderm (TN); Estrasorb (TN); Estring (TN); Estrogel (TN); Innofem (TN); Vagifem (TN); Vivelle (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00107 |
Tacrolimus (USP/INN); Tacrolimus hydrate (JP18); Prograf (TN); Protopic (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00136 |
Haloperidol (JP18/USP/INN); Haldol (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00184 |
Cyclosporine (USP); Ciclosporin (JP18); Gengraf (TN); Neoral (TN); Restasis (TN); Sandimmune (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00211 |
Rifampin (USP); Rifampicin (JP18/INN); Rifadin (TN); Rimactane (TN) |
(P) CYP induction: CYP3A4 |
| D00246 |
Budesonide (JP18/USP/INN); Entocort EC (TN); Pulmicort (TN); Rhinocort (TN); Uceris (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00252 |
Carbamazepine (JP18/USP/INN); Equetro (TN); Tegretol (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / CYP induction: CYP3A4 |
| D00283 |
Clozapine (JAN/USP/INN); Clozaril (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00292 |
Dexamethasone (JP18/USP/INN); Decadron (TN); Maxidex (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / CYP induction: CYP3A4 |
| D00293 |
Diazepam (JP18/USP/INN); Diastat (TN); Valium (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00318 |
Famotidine (JP18/USP/INN); Fluxid (TN); Pepcid (TN) |
(P) unclassified |
| D00320 |
Fentanyl (JAN/USP/INN); Duragesic (TN); Subsys (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00336 |
Glyburide (USP); Glibenclamide (JP18/INN); Diabeta (TN); Glynase (TN); Micronase (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00420 |
Mitotane (JAN/USP/INN); Lysodren (TN) |
(P) unclassified |
| D00424 |
Rifabutin (JAN/USP/INN); Mycobutin (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00426 |
Risperidone (JP18/USP/INN); Risperdal (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00427 |
Ritonavir (JAN/USP/INN); Norvir (TN) |
(P) unclassified |
| D00435 |
Nevirapine (JAN/USP/INN); Viramune (TN) |
(CI,P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00458 |
Quetiapine fumarate (JP18/USP); Seroquel (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00491 |
Paclitaxel (JAN/USP/INN); Abraxane (TN); Taxol (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00506 |
Phenobarbital (JP18/USP/INN); Luminal (TN) |
(P) unclassified |
| D00512 |
Phenytoin (JP18/USP/INN); Dilantin (TN) |
(P) unclassified |
| D00528 |
Caffeine (USP); Anhydrous caffeine (JP18); Anhydrous caffeine (TN); Respia (TN) |
(P) unclassified |
| D00550 |
Midazolam (JAN/USP/INN); Dormicum (TN); Buccolam (TN); Nayzilam (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00563 |
Mirtazapine (JAN/USP/INN); Remeron (TN); Reflex (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00570 |
Colchicine (JP18/USP); Colchicine (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D00593 |
Glimepiride (JP18/USP/INN); Amaryl (TN) |
(P) unclassified |
| D00606 |
Guanfacine hydrochloride (JAN/USP); Intuniv (TN); Tenex (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00615 |
Amlodipine besylate (USP); Amlodipine besilate (JP18); Norvasc (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00617 |
Nicardipine hydrochloride (JP18/USAN); Cardene (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00636 |
Amiodarone hydrochloride (JP18/USP); Ancaron (TN); Cordarone (TN); Nexterone (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00661 |
Cevimeline hydrochloride (USAN); Cevimeline hydrochloride hydrate (JAN); Evoxac (TN); Saligren (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00670 |
Donepezil hydrochloride (JP18/USP); Aricept (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00680 |
Methylergonovine maleate (USP); Methylergometrine maleate (JP18); Methergine (TN) |
(CI) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00687 |
Salmeterol xinafoate (JAN/USP); Serevent (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00690 |
Mometasone furoate (JAN/USP); Asmanex (TN); Elocon (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00701 |
Phenobarbital sodium (JAN/USP/INN); Luminal sodium (TN) |
(P) unclassified |
| D00722 |
Oxybutynin chloride (USP); Oxybutynin hydrochloride (JP18); Ditropan (TN); Gelnique (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00753 |
Sirolimus (JAN/USAN/INN); Rapamune (TN); Rapamycin (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D00780 |
Bromocriptine mesylate (USP); Bromocriptine mesilate (JP18); Parlodel (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00809 |
Amitriptyline hydrochloride (JP18/USP); Elavil (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00820 |
Trazodone hydrochloride (JAN/USP); Desyrel (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00821 |
Venlafaxine hydrochloride (JAN/USP); Effexor (TN) |
(P) unclassified |
| D00831 |
Mefloquine hydrochloride (JP18/USP); Lariam (TN) |
(P) unclassified |
| D00836 |
Buprenorphine hydrochloride (JP18/USP); Buprenex (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00961 |
Bicalutamide (JP18/USP/INN); Casodex (TN) |
(P) CYP inhibition: CYP3A4 |
| D00964 |
Letrozole (JAN/USP/INN); Femara (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00975 |
Dexamethasone sodium phosphate (JAN/USP); Dalalone (TN); Maxidex (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / CYP induction: CYP3A4 |
| D01061 |
Irinotecan hydrochloride (USP); Irinotecan hydrochloride hydrate (JP18); Irinotecan hydrochloride trihydrate; CPT 11; CPT-11; Campto (TN); Camptosar (TN); Onivyde (TN) |
(P) unclassified |
| D01068 |
Vinblastine sulfate (JP18/USP); Exal (TN); Velban (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01104 |
Barnidipine hydrochloride (JAN); Hypoca (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01115 |
Eplerenone (JP18/USAN/INN); Inspra (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01145 |
Azelnidipine (JP18/INN); Calblock (TN) |
(CI) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01148 |
Tolterodine tartrate (JAN/USP); Detrol (TN); Detrusitol (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01164 |
Aripiprazole (JAN/USP/INN); Abilify (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01173 |
Cilnidipine (JP18/INN); Atelec (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01176 |
Blonanserin (JAN/INN); AD 5423 |
(CI,P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01213 |
Tolvaptan (JAN/USAN/INN); Samsca (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D01227 |
Bosentan (USAN); Bosentan hydrate (JAN); Tracleer (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / CYP induction: CYP3A4 |
| D01253 |
Clobazam (JAN/USAN/INN); Mystan (TN); Onfi (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01269 |
Solifenacin succinate (JAN/USAN/INN); Vesicare (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01280 |
Warfarin potassium (JP18); Athrombin-K (TN) |
(P) unclassified |
| D01287 |
Levobupivacaine hydrochloride (JAN/USAN); Chirocaine (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01372 |
Zopiclone (JP18/INN); Amoban (TN); Zopiclone (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01399 |
Fentanyl citrate (JP18/USP); Abstral (TN); Fentora (TN); Lazanda (TN); Oralet (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01418 |
Tamibarotene (JAN/USAN/INN); Am 80; Amnoid (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01441 |
Imatinib mesylate (USAN); Imatinib mesilate (JAN); Gleevec (TN); Glivec (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01703 |
Ciclesonide (JAN/USAN/INN); Alvesco (TN); Omnaris (TN); Zetonna (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01708 |
Fluticasone propionate (JAN/USP); Cutivate (TN); Flonase (TN); Flovent (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01744 |
Brotizolam (JP18/USAN/INN); Lendormin (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01745 |
Domperidone (JP18/USAN/INN); Motilium (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01769 |
Vindesine sulfate (JAN/USAN); Fildesin (TN) |
(P) unclassified |
| D01896 |
Cilostazol (JP18/USP/INN); Pletal (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01898 |
Haloperidol decanoate (JAN/USP); Halomonth (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01915 |
Rosuvastatin calcium (JP18/USP); ZD 4522; Crestor (TN) |
(P) unclassified |
| D01935 |
Vinorelbine tartrate (USP); Vinorelbine ditartrate (JAN); KW 2307; Navelbine (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01965 |
Silodosin (JP18/INN); KMD 3213; Rapaflo (TN); Urief (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D01977 |
Gefitinib (JP18/USAN/INN); Iressa (TN) |
(P) unclassified |
| D02008 |
Tadalafil (JAN/USP/INN); Adcirca (TN); Cialis (TN); Zalutia (TN) |
(CI,P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D02102 |
Methadone hydrochloride (JAN/USP); Dolophine hydrochloride (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / CYP induction: CYP3A4 / Transporter inhibition: ABCB1 |
| D02103 |
Phenytoin sodium (USP); Phenytoin sodium for injection (JP18); Aleviatin (TN); Dilantin (TN) |
(P) unclassified |
| D02165 |
Docetaxel (USP); Docetaxel hydrate (JP18); Docetaxel trihydrate; Taxotere (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D02197 |
Vincristine sulfate (JP18/USP); VCR; Marqibo (TN); Oncovin (TN); Vincasar (TN); Vincrex (TN) |
(P) unclassified |
| D02229 |
Sildenafil citrate (JAN/USP); Revatio (TN); Viagra (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D02258 |
Atorvastatin calcium (USP); Atorvastatin calcium hydrate (JP18); Atorvastatin calcium trihydrate; Atorvaliq (TN); Lipitor (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D02372 |
Perospirone hydrochloride hydrate (JAN); Lullan (TN) |
(P) unclassified |
| D02484 |
Artemether and lumefantrine; Coartem (TN) |
(P) unclassified |
| D02498 |
Lopinavir and ritonavir; Kaletra (TN) |
(P) unclassified |
| D02624 |
Eszopiclone (JAN/USP/INN); Estorra (TN); Lunesta (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D02689 |
Ramelteon (JAN/USAN/INN); Rozerem (TN) |
(P) unclassified |
| D02691 |
Somatropin (USP/INN); Somatropin (genetical recombination) (JAN); Human growth hormone (JAN); Asellacrin (TN); Humatrope (TN); Nutropin (TN); Omnitrope (TN) |
(P) unclassified |
| D02714 |
Everolimus (JAN/USAN/INN); Afinitor (TN); Votubia (TN); Zortress (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D02732 |
Pranlukast hydrate (JP18); Onon (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D02968 |
Aprepitant (JAN/USP/INN); Aponvie (TN); Emend (TN); Cinvanti (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / CYP induction: CYP3A4 |
| D03106 |
Bexarotene (JAN/USAN/INN); Targretin (TN) |
(P) unclassified |
| D03150 |
Bortezomib (JAN/USAN/INN); Velcade (TN) |
(P) unclassified |
| D03213 |
Apixaban (JAN/USAN/INN); Eliquis (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D03218 |
Axitinib (JAN/USAN); Inlyta (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D03260 |
Vardenafil hydrochloride hydrate (JAN); Vardenafil monohydrochloride trihydrate; Levitra (TN); Staxyn (TN) |
(CI,P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D03505 |
Cinacalcet hydrochloride (JAN/USAN); Sensipar (TN); Mimpara (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D03658 |
Dasatinib (JAN/INN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D03669 |
Deferasirox (JAN/USAN/INN); Exjade (TN); Jadenu (TN) |
(P) CYP induction: CYP3A4 |
| D03693 |
Desloratadine (JAN/USP/INN); Clarinex (TN) |
(P) unclassified |
| D03799 |
Dienogest (JAN/USAN/INN); Endometrion (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D03820 |
Dutasteride (JAN/USP/INN); Avodart (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D04023 |
Erlotinib hydrochloride (JAN/USAN); Tarceva (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D04024 |
Lapatinib ditosylate (USAN); Lapatinib tosilate hydrate (JAN); Lapatinib ditosylate monohydrate; Tykerb (TN); Tyverb (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D04641 |
Istradefylline (JAN/USAN/INN); Nourianz (TN); Nouriast (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D04666 |
Lanreotide acetate (JAN/USAN); Somatuline (TN) |
(P) unclassified |
| D04768 |
Lonafarnib (JAN/USAN/INN); Zokinvy (TN) |
(CI,P) unclassified |
| D04820 |
Lurasidone hydrochloride (JAN/USAN); SM 13496; Latuda (TN) |
(CI,P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D05380 |
Pazopanib hydrochloride (JAN/USAN); Votrient (TN) |
(P) unclassified |
| D05462 |
Oxycodone hydrochloride hydrate (JP18) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D05775 |
Rufinamide (JAN/USP/INN); Banzel (TN) |
(P) unclassified |
| D05928 |
Stiripentol (JAN/USAN/INN); Diacomit (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D06068 |
Temsirolimus (JAN/USAN/INN); Torisel (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D06199 |
Trabectedin (JAN/USAN/INN); Yondelis (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D06273 |
Imidafenacin (JAN/INN); Uritos (TN); Staybla (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D06315 |
Fluticasone furoate (JAN/USAN/INN); Veramyst (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D06402 |
Sunitinib malate (JAN/USAN); Sutent (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D06405 |
Nalfurafine hydrochloride (JAN/USAN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D06412 |
Aliskiren fumarate (JAN/USAN); Aliskiren hemifumarate; Tekturna (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D06413 |
Nilotinib hydrochloride hydrate (JAN); Nilotinib monohydrochloride monohydrate; Tasigna (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D06414 |
Dasatinib (USAN); Dasatinib hydrate (JAN); Sprycel (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D06478 |
Darunavir ethanolate (JAN); Prezista (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D06597 |
Fosaprepitant dimeglumine (USAN); Fosaprepitant meglumine (JAN); Proemend (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / CYP induction: CYP3A4 |
| D06637 |
Romidepsin (JAN/USAN/INN); Istodax (TN) |
(P) unclassified |
| D06670 |
Maraviroc (JAN/INN); Selzentry (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D07082 |
Dabigatran etexilate mesylate (USAN); Dabigatran etexilate methanesulfonate (JAN); Dabigatran etexilate mesilate; Pradaxa (TN) |
(CI,P) Transporter inhibition: ABCB1 |
| D07086 |
Rivaroxaban (JAN/USAN/INN); Xarelto (TN) |
(CI) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D07569 |
Candesartan cilexetil and anmlodipine besylate (JP18); Unisia (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D07583 |
Phenytoin and phenobarbital; Aleviatin with phenobarbital (TN) |
(P) unclassified |
| D07585 |
Isopropylantipyrine, ergotamine tartrate and anhydrous caffeine; Cleamine A (TN) |
(CI) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D07595 |
Fosphenytoin sodium hydrate (JAN); Fostoin (TN) |
(P) CYP induction: CYP3A4 |
| D07866 |
Docetaxel (JAN/INN); Docetaxel (TN); Taxotere (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D07869 |
Donepezil (JAN/INN); Donaz (TN); Allydone (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D08095 |
Ivabradine hydrochloride (JAN/USAN); Ivabrandine hydrochloride; Corlanor (TN); Corlentor (TN); Coralan (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D08488 |
Amlodipine besilate and atorvastatin calcium; Caduet (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D08497 |
Rupatadine fumarate (JAN); Rinialer (TN); Rupafin (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D08699 |
Salmeterol xinafoate and fluticasone propionate; Adoair diskus (TN); Aerivio Spiromax (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D08856 |
Anamorelin hydrochloride (JAN/USAN); Adlumiz (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D08923 |
Fesoterodine fumarate (JAN/USAN); Toviaz (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D08976 |
Pomalidomide (JAN/USAN/INN); Pomalyst (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D09017 |
Ticagrelor (JAN/USAN/INN); Brilinta (TN) |
(CI,P) Transporter inhibition: ABCB1 |
| D09187 |
Estradiol and levonorgestrel; Wellnara (TN); Climara pro (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D09319 |
Indacaterol maleate (JAN/USAN); Arcapta neohaler (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D09348 |
Fostamatinib disodium (USAN); Fostamatinib sodium hydrate (JAN); Fostamatinib disodium hexahydrate; Tavalisse (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D09546 |
Edoxaban tosilate hydrate (JAN); Edoxaban tosylate monohydrate; Lixiana (TN); Savaysa (TN) |
(P) Transporter inhibition: ABCB1 |
| D09572 |
Riociguat (JAN/USAN/INN); Adempas (TN) |
(CI,P) Transporter inhibition: ABCB1 |
| D09587 |
Brentuximab vedotin (USAN/INN); Brentuximab vedotin (genetical recombination) (JAN); Adcetris (TN) |
(P) unclassified |
| D09594 |
Olmesartan medoxomil and azelnidipine; Rezaltas (TN) |
(CI) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D09595 |
Budesonide and formoterol fumarate dihydrate; Symbicort (TN); Budeforu (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D09638 |
Lomitapide mesylate (USAN); Lomitapide mesilate (JAN); Juxtapid (TN); Lojuxta (TN) |
(CI,P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D09728 |
Bosutinib hydrate (JAN); Bosutinib monohydrate; Bosulif (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D09730 |
Olaparib (JAN/USAN/INN); Lynparza (TN) |
(P) unclassified |
| D09731 |
Crizotinib (JAN/USAN/INN); Xalkori (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D09733 |
Afatinib dimaleate (USAN); Afatinib maleate (JAN); Gilotrif (TN); Giotrif (TN) |
(P) Transporter inhibition: ABCB1 |
| D09743 |
Telmisartan and amlodipine besilate (JP18); Telmisartan and amlodipine besylate; Micamlo (TN); Twynsta (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D09745 |
Valsartan and amlodipine besilate; Exforge (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D09753 |
Saxagliptin hydrate (JAN); Onglyza (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D09783 |
Tofacitinib citrate (JAN/USAN); Tasocitinib citrate; Xeljanz (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D09799 |
Carotegrast methyl (JAN); Carogra (TN) |
(P) CYP inhibition: CYP3A4 |
| D09848 |
Pioglitazone hydrochloride and glimepiride tablets (JP18); Pioglitazone and glimepiride; Duetact; Sonias (TN) |
(P) unclassified |
| D09873 |
Bedaquiline fumarate (JAN/USAN); Sirturo (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D09894 |
Eliglustat tartrate (JAN/USAN); Eliglustat hemitartrate; Cerdelga (TN) |
(CI,P) Transporter inhibition: ABCB1 |
| D09920 |
Lenvatinib mesylate (USAN); Lenvatinib mesilate (JAN); Lenvima (TN) |
(P) Transporter inhibition: ABCB1 |
| D09951 |
Ponatinib hydrochloride (JAN/USAN); Iclusig (TN) |
(P) unclassified |
| D09956 |
Quizartinib dihydrochloride (USAN); Quizartinib hydrochloride (JAN); Vanflyta (TN) |
(P) unclassified |
| D09960 |
Ruxolitinib phosphate (JAN/USAN); Jakafi (TN); Jakavi (TN); Opzelura (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D09996 |
Vemurafenib (JAN/USAN/INN); Zelboraf (TN) |
(P) CYP induction: CYP3A4 |
| D10003 |
Hemin (JAN); Normosang (TN); Panhematin (TN) |
(P) CYP induction: CYP3A4 |
| D10024 |
Selumetinib sulfate (JAN/USAN); Koselugo (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10082 |
Suvorexant (JAN/USAN); MK-4305; Belsomra (TN) |
(P) unclassified |
| D10095 |
Cabozantinib s-malate (USAN); Cabozantinib malate (JAN); Cometriq (TN); Cabometyx (TN) |
(P) unclassified |
| D10104 |
Dabrafenib mesylate (USAN); Dabrafenib mesilate (JAN); Tafinlar (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / CYP induction: CYP3A4 |
| D10135 |
Macitentan (JAN/USAN); Opsumit (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10137 |
Regorafenib hydrate (JAN); Stivarga (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D10161 |
Sarilumab (USAN); Sarilumab (genetical receombination) (JAN); Kevzara (TN) |
(P) unclassified |
| D10218 |
Enzalutamide (JAN/USAN); Xtandi (TN) |
(P) unclassified |
| D10223 |
Ibrutinib (JAN/USAN); Imbruvica (TN) |
(CI,P) unclassified |
| D10243 |
Irbesartan and amlodipine besilate (JP18); Aimix (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10309 |
Brexpiprazole (JAN/USAN/INN); Rexulti (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10372 |
Palbociclib (JAN/USAN); Ibrance (TN) |
(P) unclassified |
| D10385 |
Ezetimibe and atorvastatin; Atozet (TN); Liptruzet (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10396 |
Nintedanib esylate (USAN); Nintedanib ethanesulfonate (JAN); Ofev (TN) |
(P) Transporter inhibition: ABCB1 |
| D10433 |
Vibegron (JAN/USAN/INN); Beova (TN); Gemtesa (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D10450 |
Alectinib hydrochloride (JAN); Alecensa (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10452 |
Cabazitaxel acetonate (JAN); Cabazitaxel acetone; Jevtana (TN) |
(P) unclassified |
| D10466 |
Vonoprazan fumarate (JAN/USAN); Takecab (TN); Voquezna (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10478 |
Naldemedine tosylate (JAN/USAN); Naldemedine tosilate; Symproic (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10501 |
Fluticasone furoate and vilanterol trifenatate; Breo ellipta (TN); Relvar ellipita (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10505 |
Glycopyrronium bromide and indacaterol maleate; Ultibro (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D10506 |
Fluticasone propionate and formoterol fumarate hydrate; Flutiform (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10516 |
Aripiprazole hydrate (JAN); Aripiprazole monohydrate; Abilify maintena (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10524 |
Azilsartan and amlodipine besilate; Zacras (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10525 |
Valsartan and cilnidipine; Atedio (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10533 |
Umeclidinium bromide and vilanterol; Anoro (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10551 |
Ceritinib (JAN/USAN/INN); Zykadia (TN) |
(P) unclassified |
| D10564 |
Amenamevir (JAN/INN); Amenalief (TN) |
(P) unclassified |
| D10566 |
Pasireotide pamoate (JAN); Signifor lar (TN) |
(P) unclassified |
| D10633 |
Finerenone (JAN/USAN/INN); Kerendia (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10643 |
Isavuconazonium sulfate (JAN/USAN); Cresemba (TN) |
(P) unclassified |
| D10679 |
Venetoclax (JAN/USAN/INN); Venclexta (TN) |
(CI,P) unclassified |
| D10688 |
Abemaciclib (JAN/USAN/INN); Verzenio (TN) |
(P) unclassified |
| D10727 |
Sodium zirconium cyclosilicate (USAN); Sodium zirconium cyclosilicate hydrate (JAN); Lokelma (TN) |
(P) unclassified |
| D10733 |
Talazoparib tosylate (USAN); Talazoparib tosilate (JAN); Talzenna (TN) |
(P) unclassified |
| D10761 |
Polatuzumab vedotin (USAN); Polatuzumab vedotin (genetical recombination) (JAN); Polatuzumab vedotin-piiq; Polivy (TN) |
(P) unclassified |
| D10762 |
Fosravuconazole L-lysine ethanolate (JAN) |
(P) unclassified |
| D10774 |
Vonoprazan, amoxicillin and metronidazole; Vonopion (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10775 |
Vonoprazan, amoxicillin and clarithromycin; Vonosap (TN); Voquenza (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10780 |
Perampanel hydrate (JAN); Fycompa (TN) |
(P) unclassified |
| D10800 |
Gilteritinib fumarate (JAN/USAN); Xospata (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D10801 |
Letermovir (JAN/USAN/INN); Prevymis (TN) |
(P) unclassified |
| D10805 |
Telmisartan, amlodipine and hydrochlorothiazide; Micatrio (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10832 |
Darunavir and cobicistat; Prezcobix (TN); Rezolsta (TN) |
(P) unclassified |
| D10866 |
Brigatinib (JAN/USAN); Alunbrig (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10891 |
Capmatinib hydrochloride (USAN); Capmatinib hydrochloride hydrate (JAN); Tabrecta (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10892 |
Esaxerenone (JAN/INN) |
(P) unclassified |
| D10893 |
Acalabrutinib (JAN/USAN/INN); Calquence (TN) |
(P) unclassified |
| D10926 |
Entrectinib (JAN/USAN/INN); Rozlytrek (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D10990 |
Somatrogon (USAN/INN); Somatrogon (genetical recombination) (JAN); Somatrogon-ghla; Ngenla (TN) |
(P) unclassified |
| D10993 |
Tucidinostat (JAN/USAN/INN); Hiyasta (TN) |
(P) unclassified |
| D10999 |
Valbenazine tosylate (USAN); Valbenazine tosilate (JAN); Valbenazine ditosylate; Ingrezza (TN); Dysval (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D11012 |
Lorlatinib (JAN/USAN/INN); Lorbrena (TN) |
(P) unclassified |
| D11022 |
Lemborexant (JAN/USAN/INN); Dayvigo (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D11035 |
Fluticasone furoate, umeclidinium bromide and vilanterol; Trelegy ellipta (TN) |
(P) unclassified |
| D11040 |
Apalutamide (JAN/INN); Erleada (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / CYP induction: CYP3A4 |
| D11048 |
Upadacitinib hydrate (JAN); Upadacitinib hemihydrate; Rinvoq (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D11053 |
Encorafenib (JAN/USAN/INN); Braftovi (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D11070 |
Tirabrutinib hydrochloride (JAN/USAN); Velexbru (TN) |
(P) unclassified |
| D11093 |
Avacopan (JAN/USAN/INN); Tavneos (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D11138 |
Larotrectinib sulfate (JAN/USAN); Vitrakvi (TN) |
(P) unclassified |
| D11194 |
Somapacitan (USAN/INN); Somapacitan (genetical recombination) (JAN); Somapacitan-beco; Sogroya (TN) |
(P) unclassified |
| D11370 |
Fosnetupitant chloride hydrochloride (JAN/USAN); Arokaris (TN) |
(P) unclassified |
| D11382 |
Darunavir, cobicistat, emtricitabine and tenofovir alafenamide; Symtuza (TN) |
(P) unclassified |
| D11417 |
Pemigatinib (JAN/USAN/INN); Pemazyre (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D11485 |
Tazemetostat hydrobromide (JAN/USAN); Tazverik (TN) |
(P) Transporter inhibition: ABCB1 |
| D11520 |
Ezetimibe and rosuvastatin; Roszet (TN); Rosuzet (TN) |
(P) unclassified |
| D11525 |
Enfortumab vedotin (USAN); Enfortumab vedotin (genetical recombination) (JAN); Enfortumab vedotin-ejfv; Padcev (TN) |
(P) unclassified |
| D11584 |
Budesonide, glycopyrronium bromide and formoterol fumarate; Budesonide, glycopyrrolate and formoterol fumarate; Breztri (TN) |
(P) unclassified |
| D11659 |
Tolvaptan sodium phosphate (JAN); Samtasu (TN) |
(P) unclassified |
| D11662 |
Valemetostat tosilate (JAN); Valemetostat tosylate; Ezharmia (TN) |
(P) unclassified |
| D11674 |
Berotralstat hydrochloride (JAN/USAN); Orladeyo (TN) |
(P) CYP inhibition: CYP3A4 / Transporter inhibition: ABCB1 |
| D11713 |
Selpercatinib (JAN/USAN/INN); Retevmo (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D11725 |
Futibatinib (JAN/USAN/INN); Lytgobi (TN) |
(P) unclassified |
| D11804 |
Aspirin and vonoprazan; Cabpirin (TN) |
(P) unclassified |
| D11861 |
Indacaterol acetate, glycopyrronium bromide and mometasone furoate; Enerzair (TN) |
(P) unclassified |
| D11862 |
Indacaterol and mometasone furoate; Atectura (TN) |
(P) unclassified |
| D11920 |
Pimitespib (JAN); Jeselhy (TN) |
(P) unclassified |
| D11970 |
Ritlecitinib tosylate (USAN); Ritlecitinib tosilate (JAN); Litfulo (TN) |
(P) unclassified |
| D12055 |
Sotorasib (JAN/USAN); Lumakras (TN) |
(P) unclassified |
| D12269 |
Nirmatrelvir and ritonavir; Paxlovid (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D12311 |
Bortezomib hydrate (JAN) |
(P) unclassified |
| D12586 |
Mifepristone and misoprostol; Mefeego (TN) |
(P) unclassified |
