| D00211 |
Rifampin (USP); Rifampicin (JP18/INN); Rifadin (TN); Rimactane (TN) |
(P) CYP induction: CYP3A4 |
| D00236 |
Atovaquone (JAN/USP/INN); Mepron (TN) |
(P) unclassified |
| D00241 |
Baclofen (JP18/USP/INN); Kemstro (TN); Lioresal (TN) |
(P) unclassified |
| D00276 |
Clarithromycin (JP18/USP/INN); Biaxin (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00283 |
Clozapine (JAN/USP/INN); Clozaril (TN) |
(P) Enzyme: CYP3A4 |
| D00292 |
Dexamethasone (JP18/USP/INN); Decadron (TN); Maxidex (TN) |
(P) Enzyme: CYP3A4 / CYP induction: CYP3A4 |
| D00293 |
Diazepam (JP18/USP/INN); Diastat (TN); Valium (TN) |
(P) Enzyme: CYP2C19 CYP3A4 / Target: GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ |
| D00295 |
Cimetidine (JP18/USP/INN); Tagamet (TN) |
(P) CYP inhibition: CYP3A4 |
| D00320 |
Fentanyl (JAN/USP/INN); Duragesic (TN); Subsys (TN) |
(P) Enzyme: CYP3A4 |
| D00350 |
Itraconazole (JP18/USP); Itrizole (TN); Sporanox (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D00420 |
Mitotane (JAN/USP/INN); Lysodren (TN) |
(P) unclassified |
| D00435 |
Nevirapine (JAN/USP/INN); Viramune (TN) |
(P) Enzyme: CYP3A4 |
| D00454 |
Olanzapine (JAN/USP/INN); Zyprexa (TN) |
(P) unclassified |
| D00506 |
Phenobarbital (JP18/USP/INN); Luminal (TN) |
(P) Target: GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ |
| D00512 |
Phenytoin (JP18/USP/INN); Dilantin (TN) |
(P) unclassified |
| D00528 |
Caffeine (USP); Anhydrous caffeine (JP18); Anhydrous caffeine (TN); Respia (TN) |
(P) unclassified |
| D00545 |
Isoflurane (JP18/USP/INN); Forane (TN) |
(P) unclassified |
| D00546 |
Desflurane (JAN/USP/INN); Suprane (TN) |
(P) unclassified |
| D00549 |
Propofol (JAN/USP/INN); Diprivan (TN) |
(P) Target: GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ |
| D00550 |
Midazolam (JAN/USP/INN); Dormicum (TN); Buccolam (TN); Nayzilam (TN) |
(P) Enzyme: CYP3A4 / Target: GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ |
| D00563 |
Mirtazapine (JAN/USP/INN); Remeron (TN); Reflex (TN) |
(P) Enzyme: CYP3A4 |
| D00606 |
Guanfacine hydrochloride (JAN/USP); Intuniv (TN); Tenex (TN) |
(P) Enzyme: CYP3A4 |
| D00636 |
Amiodarone hydrochloride (JP18/USP); Ancaron (TN); Cordarone (TN); Nexterone (TN) |
(P) Enzyme: CYP3A4 |
| D00665 |
Chlorpheniramine maleate (JP18/USP); Chlor-trimeton (TN); Teldrin (TN) |
(P) unclassified |
| D00669 |
Diphenhydramine hydrochloride (JP18/USP); Benadryl (TN) |
(P) unclassified |
| D00697 |
Flumazenil (JAN/USP/INN); Romazicon (TN) |
(P) Target: GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ |
| D00701 |
Phenobarbital sodium (JAN/USP/INN); Luminal sodium (TN) |
(P) Target: GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ |
| D00710 |
Valproate sodium (USAN); Sodium valproate (JP18); Depakene (TN); Selenica (TN) |
(P) unclassified |
| D00754 |
Thalidomide (JAN/USP/INN); Thalomid (TN); Thaled (TN) |
(P) unclassified |
| D00783 |
Botulinum toxin type A (JAN); Botox (TN); Dysport (TN) |
(P) unclassified |
| D00811 |
Clomipramine hydrochloride (JP18/USP); Anafranil (TN) |
(P) Enzyme: CYP3A4 CYP2C19 |
| D00815 |
Imipramine hydrochloride (JP18/USP); Tofranil (TN) |
(P) Enzyme: CYP3A4 CYP2C19 |
| D00818 |
Maprotiline hydrochloride (JP18/USP); Ludiomil (TN) |
(P) unclassified |
| D00824 |
Fluvoxamine maleate (JP18/USP); Luvox (TN) |
(P) CYP inhibition: CYP2C19 CYP3A4 |
| D00831 |
Mefloquine hydrochloride (JP18/USP); Lariam (TN) |
(P) unclassified |
| D00836 |
Buprenorphine hydrochloride (JP18/USP); Buprenex (TN) |
(P) Enzyme: CYP3A4 |
| D00961 |
Bicalutamide (JP18/USP/INN); Casodex (TN) |
(P) CYP inhibition: CYP3A4 |
| D01145 |
Azelnidipine (JP18/INN); Calblock (TN) |
(P) Enzyme: CYP3A4 |
| D01177 |
Remifentanil hydrochloride (JAN/USAN); Ultiva (TN) |
(P) unclassified |
| D01205 |
Dexmedetomidine hydrochloride (JAN/USP); Igalmi (TN); Precedex (TN) |
(P) Enzyme: CYP2C19 |
| D01253 |
Clobazam (JAN/USAN/INN); Mystan (TN); Onfi (TN) |
(P) Enzyme: CYP3A4 CYP2C19 / Target: GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ |
| D01389 |
Chlophedianol hydrochloride (USAN); Clofedanol hydrochloride (JP18); Coldrin (TN) |
(P) unclassified |
| D01399 |
Fentanyl citrate (JP18/USP); Abstral (TN); Fentora (TN); Lazanda (TN); Oralet (TN) |
(P) Enzyme: CYP3A4 |
| D01832 |
Modafinil (JAN/USP/INN); Provigil (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP2C19 / CYP induction: CYP3A4 |
| D01935 |
Vinorelbine tartrate (USP); Vinorelbine ditartrate (JAN); KW 2307; Navelbine (TN) |
(P) Enzyme: CYP3A4 |
| D02102 |
Methadone hydrochloride (JAN/USP); Dolophine hydrochloride (TN) |
(P) Enzyme: CYP3A4 CYP2C19 / CYP induction: CYP3A4 |
| D02103 |
Phenytoin sodium (USP); Phenytoin sodium for injection (JP18); Aleviatin (TN); Dilantin (TN) |
(P) unclassified |
| D02234 |
Cyproheptadine hydrochloride (JP18/USP); Cyproheptadine hydrochloride sesquihydrate; Periactin (TN) |
(P) unclassified |
| D02245 |
Trimeprazine tartrate (USP); Alimemazine tartrate (JP18); Alimezine (TN) |
(P) unclassified |
| D02253 |
Pentobarbital calcium (JP18); Ravona (TN) |
(P) Target: GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ |
| D02274 |
Dantrolene sodium (USP); Dantrolene sodium hydrate (JP18); Dantrium (TN); Ryanodex (TN) |
(P) unclassified |
| D02283 |
Iomazenil (123I) (JAN/INN); Benzodine (TN) |
(P) Target: GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ |
| D02372 |
Perospirone hydrochloride hydrate (JAN); Lullan (TN) |
(P) unclassified |
| D02484 |
Artemether and lumefantrine; Coartem (TN) |
(P) unclassified |
| D02691 |
Somatropin (USP/INN); Somatropin (genetical recombination) (JAN); Human growth hormone (JAN); Asellacrin (TN); Humatrope (TN); Nutropin (TN); Omnitrope (TN) |
(P) CYP inhibition: CYP2C19 |
| D02732 |
Pranlukast hydrate (JP18); Onon (TN) |
(P) Enzyme: CYP3A4 |
| D02735 |
Rimabotulinumtoxin B (USAN); Botulinum toxin type B (JAN); Myobloc (TN) |
(P) unclassified |
| D02968 |
Aprepitant (JAN/USP/INN); Aponvie (TN); Emend (TN); Cinvanti (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / CYP induction: CYP3A4 |
| D03106 |
Bexarotene (JAN/USAN/INN); Targretin (TN) |
(P) unclassified |
| D03658 |
Dasatinib (JAN/INN) |
(P) Enzyme: CYP3A4 |
| D03669 |
Deferasirox (JAN/USAN/INN); Exjade (TN); Jadenu (TN) |
(P) CYP induction: CYP3A4 |
| D04024 |
Lapatinib ditosylate (USAN); Lapatinib tosilate hydrate (JAN); Lapatinib ditosylate monohydrate; Tykerb (TN); Tyverb (TN) |
(P) Enzyme: CYP3A4 |
| D04641 |
Istradefylline (JAN/USAN/INN); Nourianz (TN); Nouriast (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 |
| D04666 |
Lanreotide acetate (JAN/USAN); Somatuline (TN) |
(P) unclassified |
| D04768 |
Lonafarnib (JAN/USAN/INN); Zokinvy (TN) |
(P) unclassified |
| D05775 |
Rufinamide (JAN/USP/INN); Banzel (TN) |
(P) unclassified |
| D05928 |
Stiripentol (JAN/USAN/INN); Diacomit (TN) |
(P) Enzyme: CYP2C19 CYP3A4 / CYP inhibition: CYP3A4 CYP2C19 |
| D06405 |
Nalfurafine hydrochloride (JAN/USAN) |
(P) Enzyme: CYP3A4 |
| D06413 |
Nilotinib hydrochloride hydrate (JAN); Nilotinib monohydrochloride monohydrate; Tasigna (TN) |
(P) Enzyme: CYP3A4 |
| D06414 |
Dasatinib (USAN); Dasatinib hydrate (JAN); Sprycel (TN) |
(P) Enzyme: CYP3A4 |
| D06597 |
Fosaprepitant dimeglumine (USAN); Fosaprepitant meglumine (JAN); Proemend (TN) |
(P) Enzyme: CYP3A4 / CYP inhibition: CYP3A4 / CYP induction: CYP3A4 |
| D07132 |
Buprenorphine (JAN/INN); Temgesic (TN) |
(P) Enzyme: CYP3A4 |
| D07523 |
Betaine (JAN); Cystadane (TN) |
(P) unclassified |
| D07583 |
Phenytoin and phenobarbital; Aleviatin with phenobarbital (TN) |
(P) unclassified |
| D07595 |
Fosphenytoin sodium hydrate (JAN); Fostoin (TN) |
(P) CYP induction: CYP3A4 |
| D09594 |
Olmesartan medoxomil and azelnidipine; Rezaltas (TN) |
(P) Enzyme: CYP3A4 |
| D09638 |
Lomitapide mesylate (USAN); Lomitapide mesilate (JAN); Juxtapid (TN); Lojuxta (TN) |
(P) Enzyme: CYP3A4 |
| D09731 |
Crizotinib (JAN/USAN/INN); Xalkori (TN) |
(P) Enzyme: CYP3A4 |
| D09799 |
Carotegrast methyl (JAN); Carogra (TN) |
(P) CYP inhibition: CYP3A4 |
| D09996 |
Vemurafenib (JAN/USAN/INN); Zelboraf (TN) |
(P) CYP induction: CYP3A4 |
| D10003 |
Hemin (JAN); Normosang (TN); Panhematin (TN) |
(P) CYP induction: CYP3A4 |
| D10012 |
Incobotulinumtoxin A (JAN/USAN); Onaclostox; Xeomin (TN) |
(P) unclassified |
| D10104 |
Dabrafenib mesylate (USAN); Dabrafenib mesilate (JAN); Tafinlar (TN) |
(P) Enzyme: CYP3A4 / CYP induction: CYP3A4 |
| D10161 |
Sarilumab (USAN); Sarilumab (genetical receombination) (JAN); Kevzara (TN) |
(P) unclassified |
| D10194 |
Remimazolam besylate (USAN); Remimazolam besilate (JAN); Anerem (TN); Byfavo (TN) |
(P) Target: GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ |
| D10218 |
Enzalutamide (JAN/USAN); Xtandi (TN) |
(P) unclassified |
| D10372 |
Palbociclib (JAN/USAN); Ibrance (TN) |
(P) unclassified |
| D10466 |
Vonoprazan fumarate (JAN/USAN); Takecab (TN); Voquezna (TN) |
(P) Enzyme: CYP2C19 CYP3A4 |
| D10519 |
Rabeprazole, amoxicillin and clarithromycin; Rabecure (TN) |
(P) Enzyme: CYP2C19 CYP3A4 / CYP inhibition: CYP3A4 |
| D10551 |
Ceritinib (JAN/USAN/INN); Zykadia (TN) |
(P) unclassified |
| D10564 |
Amenamevir (JAN/INN); Amenalief (TN) |
(P) unclassified |
| D10566 |
Pasireotide pamoate (JAN); Signifor lar (TN) |
(P) unclassified |
| D10643 |
Isavuconazonium sulfate (JAN/USAN); Cresemba (TN) |
(P) unclassified |
| D10762 |
Fosravuconazole L-lysine ethanolate (JAN) |
(P) unclassified |
| D10774 |
Vonoprazan, amoxicillin and metronidazole; Vonopion (TN) |
(P) Enzyme: CYP2C19 CYP3A4 |
| D10775 |
Vonoprazan, amoxicillin and clarithromycin; Vonosap (TN); Voquenza (TN) |
(P) Enzyme: CYP2C19 CYP3A4 / CYP inhibition: CYP3A4 |
| D10801 |
Letermovir (JAN/USAN/INN); Prevymis (TN) |
(P) CYP induction: CYP2C19 |
| D10926 |
Entrectinib (JAN/USAN/INN); Rozlytrek (TN) |
(P) Enzyme: CYP3A4 |
| D10990 |
Somatrogon (USAN/INN); Somatrogon (genetical recombination) (JAN); Somatrogon-ghla; Ngenla (TN) |
(P) unclassified |
| D11012 |
Lorlatinib (JAN/USAN/INN); Lorbrena (TN) |
(P) unclassified |
| D11040 |
Apalutamide (JAN/INN); Erleada (TN) |
(P) Enzyme: CYP3A4 / CYP induction: CYP3A4 CYP2C19 |
| D11062 |
Osilodrostat phosphate (JAN/USAN); Isturisa (TN) |
(P) Enzyme: CYP3A4 |
| D11138 |
Larotrectinib sulfate (JAN/USAN); Vitrakvi (TN) |
(P) unclassified |
| D11194 |
Somapacitan (USAN/INN); Somapacitan (genetical recombination) (JAN); Somapacitan-beco; Sogroya (TN) |
(P) unclassified |
| D11370 |
Fosnetupitant chloride hydrochloride (JAN/USAN); Arokaris (TN) |
(P) unclassified |
| D11485 |
Tazemetostat hydrobromide (JAN/USAN); Tazverik (TN) |
(P) unclassified |
| D11674 |
Berotralstat hydrochloride (JAN/USAN); Orladeyo (TN) |
(P) CYP inhibition: CYP3A4 |
| D11713 |
Selpercatinib (JAN/USAN/INN); Retevmo (TN) |
(P) Enzyme: CYP3A4 |
| D11804 |
Aspirin and vonoprazan; Cabpirin (TN) |
(P) unclassified |
| D11920 |
Pimitespib (JAN); Jeselhy (TN) |
(P) unclassified |
| D11970 |
Ritlecitinib tosylate (USAN); Ritlecitinib tosilate (JAN); Litfulo (TN) |
(P) unclassified |
| D12055 |
Sotorasib (JAN/USAN); Lumakras (TN) |
(P) unclassified |
| D12586 |
Mifepristone and misoprostol; Mefeego (TN) |
(P) unclassified |
