<?xml version="1.0"?>
<!DOCTYPE pathway SYSTEM "http://www.genome.jp/kegg/xml/KGML_v0.7.1_.dtd">
<!-- Creation date: Oct 16, 2012 17:34:30 +0900 (GMT+09:00) -->
<pathway name="path:hsa04916" org="hsa" number="04916"
         title="Melanogenesis"
         image="http://www.genome.jp/kegg/pathway/hsa/hsa04916.png"
         link="http://www.genome.jp/kegg-bin/show_pathway?hsa04916">
    <entry id="1" name="hsa:1855 hsa:1856 hsa:1857" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:1855+hsa:1856+hsa:1857">
        <graphics name="DVL1, DVL, DVL1L1..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="337" y="275" width="46" height="17"/>
    </entry>
    <entry id="2" name="hsa:1638" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:1638">
        <graphics name="DCT, TRP-2, TYRP2" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="510" y="591" width="46" height="17"/>
    </entry>
    <entry id="3" name="hsa:7306" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:7306">
        <graphics name="TYRP1, CAS2, CATB, GP75, SHEP11, TRP, TYRP, b-PROTEIN" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="452" y="591" width="46" height="17"/>
    </entry>
    <entry id="4" name="hsa:7299" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:7299">
        <graphics name="TYR, CMM8, OCA1A, OCAIA, SHEP3" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="395" y="591" width="46" height="17"/>
    </entry>
    <entry id="5" name="hsa:4286" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:4286">
        <graphics name="MITF, CMM8, MI, WS2, WS2A, bHLHe32" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="532" y="328" width="46" height="17"/>
    </entry>
    <entry id="6" name="hsa:1638" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:1638">
        <graphics name="DCT, TRP-2, TYRP2" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="802" y="425" width="46" height="17"/>
    </entry>
    <entry id="7" name="hsa:7306" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:7306">
        <graphics name="TYRP1, CAS2, CATB, GP75, SHEP11, TRP, TYRP, b-PROTEIN" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="802" y="403" width="46" height="17"/>
    </entry>
    <entry id="8" name="hsa:7299" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:7299">
        <graphics name="TYR, CMM8, OCA1A, OCAIA, SHEP3" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="802" y="380" width="46" height="17"/>
    </entry>
    <entry id="9" name="hsa:5566 hsa:5567 hsa:5568 hsa:5613" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:5566+hsa:5567+hsa:5568+hsa:5613">
        <graphics name="PRKACA, PKACA..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="489" y="477" width="46" height="17"/>
    </entry>
    <entry id="10" name="hsa:815 hsa:816 hsa:817 hsa:818" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:815+hsa:816+hsa:817+hsa:818">
        <graphics name="CAMK2A, CAMKA..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="571" y="430" width="46" height="17"/>
    </entry>
    <entry id="11" name="hsa:163688 hsa:51806 hsa:801 hsa:805 hsa:808 hsa:810" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:163688+hsa:51806+hsa:801+hsa:805+hsa:808+hsa:810">
        <graphics name="CALML6, CAGLP..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="498" y="430" width="46" height="17"/>
    </entry>
    <entry id="12" name="hsa:2770 hsa:2771 hsa:2773 hsa:2775" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:2770+hsa:2771+hsa:2773+hsa:2775">
        <graphics name="GNAI1, Gi..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="213" y="452" width="46" height="17"/>
    </entry>
    <entry id="13" name="hsa:1910" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:1910">
        <graphics name="EDNRB, ABCDS, ET-B, ET-BR, ETB, ETBR, ETRB, HSCR, HSCR2, WS4A" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="139" y="452" width="46" height="17"/>
    </entry>
    <entry id="14" name="hsa:3815" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:3815">
        <graphics name="KIT, C-Kit, CD117, PBT, SCFR" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="139" y="363" width="46" height="17"/>
    </entry>
    <entry id="15" name="hsa:4286" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:4286">
        <graphics name="MITF, CMM8, MI, WS2, WS2A, bHLHe32" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="802" y="235" width="46" height="17"/>
    </entry>
    <entry id="16" name="cpd:C05606" type="compound"
        link="http://www.kegg.jp/dbget-bin/www_bget?C05606">
        <graphics name="C05606" fgcolor="#000000" bgcolor="#FFFFFF"
             type="circle" x="551" y="657" width="8" height="8"/>
    </entry>
    <entry id="17" name="cpd:C00082" type="compound"
        link="http://www.kegg.jp/dbget-bin/www_bget?C00082">
        <graphics name="C00082" fgcolor="#000000" bgcolor="#FFFFFF"
             type="circle" x="357" y="656" width="8" height="8"/>
    </entry>
    <entry id="18" name="hsa:4254" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:4254">
        <graphics name="KITLG, FPH2, KL-1, Kitl, MGF, SCF, SF, SHEP7" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="66" y="363" width="46" height="17"/>
    </entry>
    <entry id="19" name="cpd:C00076" type="compound"
        link="http://www.kegg.jp/dbget-bin/www_bget?C00076">
        <graphics name="C00076" fgcolor="#000000" bgcolor="#FFFFFF"
             type="circle" x="443" y="429" width="8" height="8"/>
    </entry>
    <entry id="20" name="cpd:C01245" type="compound"
        link="http://www.kegg.jp/dbget-bin/www_bget?C01245">
        <graphics name="C01245" fgcolor="#000000" bgcolor="#FFFFFF"
             type="circle" x="342" y="429" width="8" height="8"/>
    </entry>
    <entry id="21" name="cpd:C00165" type="compound"
        link="http://www.kegg.jp/dbget-bin/www_bget?C00165">
        <graphics name="C00165" fgcolor="#000000" bgcolor="#FFFFFF"
             type="circle" x="342" y="476" width="8" height="8"/>
    </entry>
    <entry id="22" name="hsa:11211 hsa:2535 hsa:7855 hsa:7976 hsa:8321 hsa:8322 hsa:8323 hsa:8324 hsa:8325 hsa:8326" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:11211+hsa:2535+hsa:7855+hsa:7976+hsa:8321+hsa:8322+hsa:8323+hsa:8324+hsa:8325+hsa:8326">
        <graphics name="FZD10, CD350, FZ-10, Fz10, FzE7, hFz10..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="139" y="275" width="46" height="17"/>
    </entry>
    <entry id="23" name="hsa:23236 hsa:5330 hsa:5331 hsa:5332" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:23236+hsa:5330+hsa:5331+hsa:5332">
        <graphics name="PLCB1, EIEE12, PI-PLC, PLC-154, PLC-I, PLC154, PLCB1A, PLCB1B..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="285" y="452" width="46" height="17"/>
    </entry>
    <entry id="24" name="hsa:434" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:434">
        <graphics name="ASIP, AGSW, AGTI, AGTIL, ASP, SHEP9" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="66" y="167" width="46" height="17"/>
    </entry>
    <entry id="25" name="hsa:1387 hsa:2033" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:1387+hsa:2033">
        <graphics name="CREBBP, CBP, KAT3A, RSTS..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="681" y="207" width="46" height="17"/>
    </entry>
    <entry id="26" name="hsa:5566 hsa:5567 hsa:5568 hsa:5613" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:5566+hsa:5567+hsa:5568+hsa:5613">
        <graphics name="PRKACA, PKACA..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="290" y="189" width="46" height="17"/>
    </entry>
    <entry id="27" name="hsa:51176 hsa:6932 hsa:6934 hsa:83439" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:51176+hsa:6932+hsa:6934+hsa:83439">
        <graphics name="LEF1, LEF-1, TCF10, TCF1ALPHA, TCF7L3..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="681" y="274" width="46" height="17"/>
    </entry>
    <entry id="28" name="hsa:2778" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:2778">
        <graphics name="GNAS, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="221" y="133" width="46" height="17"/>
    </entry>
    <entry id="29" name="hsa:5579" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:5579">
        <graphics name="PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="325" y="546" width="46" height="17"/>
    </entry>
    <entry id="30" name="hsa:10488 hsa:1385 hsa:148327 hsa:64764 hsa:84699 hsa:90993" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:10488+hsa:1385+hsa:148327+hsa:64764+hsa:84699+hsa:90993">
        <graphics name="CREB3, LUMAN, LZIP..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="681" y="190" width="46" height="17"/>
    </entry>
    <entry id="31" name="hsa:107 hsa:108 hsa:109 hsa:111 hsa:112 hsa:113 hsa:114 hsa:115 hsa:196883" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:107+hsa:108+hsa:109+hsa:111+hsa:112+hsa:113+hsa:114+hsa:115+hsa:196883">
        <graphics name="ADCY1, AC1..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="139" y="188" width="46" height="17"/>
    </entry>
    <entry id="32" name="hsa:5578 hsa:5579 hsa:5582" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:5578+hsa:5579+hsa:5582">
        <graphics name="PRKCA, AAG6, PKC-alpha, PKCA, PRKACA..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="407" y="477" width="46" height="17"/>
    </entry>
    <entry id="33" name="hsa:2932" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:2932">
        <graphics name="GSK3B" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="436" y="275" width="46" height="17"/>
    </entry>
    <entry id="34" name="hsa:1499" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:1499">
        <graphics name="CTNNB1, CTNNB" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="535" y="275" width="46" height="17"/>
    </entry>
    <entry id="35" name="hsa:5443" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:5443">
        <graphics name="POMC, ACTH, CLIP, LPH, MSH, NPP, POC" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="66" y="133" width="46" height="17"/>
    </entry>
    <entry id="36" name="hsa:2775 hsa:2776" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:2775+hsa:2776">
        <graphics name="GNAO1, G-ALPHA-o, GNAO..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="238" y="275" width="46" height="17"/>
    </entry>
    <entry id="37" name="hsa:4157" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:4157">
        <graphics name="MC1R, CMM5, MSH-R, SHEP2" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="139" y="133" width="46" height="17"/>
    </entry>
    <entry id="38" name="hsa:51384 hsa:54361 hsa:7471 hsa:7472 hsa:7473 hsa:7474 hsa:7475 hsa:7476 hsa:7477 hsa:7478 hsa:7479 hsa:7480 hsa:7481 hsa:7482 hsa:7483 hsa:7484 hsa:80326 hsa:81029 hsa:89780" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:51384+hsa:54361+hsa:7471+hsa:7472+hsa:7473+hsa:7474+hsa:7475+hsa:7476+hsa:7477+hsa:7478+hsa:7479+hsa:7480+hsa:7481+hsa:7482+hsa:7483+hsa:7484+hsa:80326+hsa:81029+hsa:89780">
        <graphics name="WNT16..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="66" y="275" width="46" height="17"/>
    </entry>
    <entry id="39" name="hsa:5594 hsa:5595" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:5594+hsa:5595">
        <graphics name="MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="456" y="363" width="46" height="17"/>
    </entry>
    <entry id="40" name="hsa:5604 hsa:5605" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:5604+hsa:5605">
        <graphics name="MAP2K1, MAPKK1, MEK1, MKK1, PRKMK1..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="376" y="363" width="46" height="17"/>
    </entry>
    <entry id="41" name="hsa:5894" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:5894">
        <graphics name="RAF1, CRAF, NS5, Raf-1, c-Raf" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="297" y="363" width="46" height="17"/>
    </entry>
    <entry id="42" name="hsa:3265 hsa:3845 hsa:4893" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:3265+hsa:3845+hsa:4893">
        <graphics name="HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="217" y="363" width="46" height="17"/>
    </entry>
    <entry id="43" name="hsa:1906" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:1906">
        <graphics name="EDN1, ET1, HDLCQ7, PPET1" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="66" y="452" width="46" height="17"/>
    </entry>
    <entry id="44" name="path:hsa04916" type="map"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa04916">
        <graphics name="TITLE:Melanogenesis" fgcolor="#000000" bgcolor="#FFFFFF"
             type="roundrectangle" x="111" y="58" width="141" height="25"/>
    </entry>
    <entry id="45" name="path:hsa04310" type="map"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa04310">
        <graphics name="Wnt signaling pathway" fgcolor="#000000" bgcolor="#FFFFFF"
             type="roundrectangle" x="321" y="239" width="109" height="34"/>
    </entry>
    <entry id="46" name="path:hsa00350" type="map"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa00350">
        <graphics name="Tyrosine metabolism" fgcolor="#000000" bgcolor="#FFFFFF"
             type="roundrectangle" x="453" y="657" width="109" height="34"/>
    </entry>
    <entry id="47" name="path:hsa05218" type="map"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa05218">
        <graphics name="Melanoma" fgcolor="#000000" bgcolor="#FFFFFF"
             type="roundrectangle" x="686" y="366" width="92" height="25"/>
    </entry>
    <entry id="48" name="path:hsa04010" type="map"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa04010">
        <graphics name="MAPK signaling pathway" fgcolor="#000000" bgcolor="#FFFFFF"
             type="roundrectangle" x="319" y="329" width="110" height="34"/>
    </entry>
    <entry id="49" name="cpd:C00575" type="compound"
        link="http://www.kegg.jp/dbget-bin/www_bget?C00575">
        <graphics name="C00575" fgcolor="#000000" bgcolor="#FFFFFF"
             type="circle" x="222" y="189" width="8" height="8"/>
    </entry>
    <entry id="50" name="undefined" type="group">
        <graphics fgcolor="#000000" bgcolor="#FFFFFF"
             type="rectangle" x="681" y="198" width="46" height="34"/>
        <component id="25"/>
        <component id="30"/>
    </entry>
    <relation entry1="35" entry2="37" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
    </relation>
    <relation entry1="37" entry2="28" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
    </relation>
    <relation entry1="28" entry2="31" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
    </relation>
    <relation entry1="26" entry2="50" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
        <subtype name="phosphorylation" value="+p"/>
    </relation>
    <relation entry1="38" entry2="22" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
        <subtype name="phosphorylation" value="+p"/>
    </relation>
    <relation entry1="22" entry2="36" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
        <subtype name="phosphorylation" value="+p"/>
    </relation>
    <relation entry1="36" entry2="1" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
        <subtype name="phosphorylation" value="+p"/>
    </relation>
    <relation entry1="1" entry2="33" type="PPrel">
        <subtype name="inhibition" value="--|"/>
    </relation>
    <relation entry1="33" entry2="34" type="PPrel">
        <subtype name="inhibition" value="--|"/>
        <subtype name="phosphorylation" value="+p"/>
    </relation>
    <relation entry1="34" entry2="27" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
    </relation>
    <relation entry1="50" entry2="15" type="GErel">
        <subtype name="expression" value="--&gt;"/>
    </relation>
    <relation entry1="27" entry2="15" type="GErel">
        <subtype name="expression" value="--&gt;"/>
    </relation>
    <relation entry1="5" entry2="8" type="GErel">
        <subtype name="expression" value="--&gt;"/>
    </relation>
    <relation entry1="5" entry2="7" type="GErel">
        <subtype name="expression" value="--&gt;"/>
    </relation>
    <relation entry1="5" entry2="6" type="GErel">
        <subtype name="expression" value="--&gt;"/>
    </relation>
    <relation entry1="18" entry2="14" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
    </relation>
    <relation entry1="14" entry2="42" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
    </relation>
    <relation entry1="42" entry2="41" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
    </relation>
    <relation entry1="41" entry2="40" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
        <subtype name="phosphorylation" value="+p"/>
    </relation>
    <relation entry1="40" entry2="39" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
        <subtype name="phosphorylation" value="+p"/>
    </relation>
    <relation entry1="39" entry2="5" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
        <subtype name="phosphorylation" value="+p"/>
    </relation>
    <relation entry1="43" entry2="13" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
    </relation>
    <relation entry1="13" entry2="12" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
    </relation>
    <relation entry1="12" entry2="23" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
    </relation>
    <relation entry1="11" entry2="10" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
    </relation>
    <relation entry1="32" entry2="9" type="PPrel">
        <subtype name="indirect effect" value="..&gt;"/>
    </relation>
    <relation entry1="29" entry2="4" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
        <subtype name="phosphorylation" value="+p"/>
    </relation>
    <relation entry1="17" entry2="16" type="PPrel">
        <subtype name="indirect effect" value="..&gt;"/>
    </relation>
    <relation entry1="23" entry2="11" type="PPrel">
        <subtype name="compound" value="19"/>
    </relation>
    <relation entry1="23" entry2="32" type="PPrel">
        <subtype name="compound" value="21"/>
    </relation>
    <relation entry1="24" entry2="37" type="PPrel">
        <subtype name="inhibition" value="--|"/>
    </relation>
</pathway>
