<?xml version="1.0"?>
<!DOCTYPE pathway SYSTEM "http://www.genome.jp/kegg/xml/KGML_v0.7.1_.dtd">
<!-- Creation date: Mar 31, 2009 09:47:13 +0900 (JST) -->
<pathway name="path:hsa05216" org="hsa" number="05216"
         title="Thyroid cancer"
         image="http://www.genome.jp/kegg/pathway/hsa/hsa05216.png"
         link="http://www.genome.jp/kegg-bin/show_pathway?hsa05216">
    <entry id="1" name="hsa:3265 hsa:3845 hsa:4893" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:3265+hsa:3845+hsa:4893">
        <graphics name="HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="369" y="309" width="46" height="17"/>
    </entry>
    <entry id="2" name="hsa:5468" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:5468">
        <graphics name="PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="762" y="410" width="46" height="17"/>
    </entry>
    <entry id="3" name="hsa:673" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:673">
        <graphics name="BRAF, B-RAF1, BRAF1, NS7, RAFB1" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="447" y="309" width="46" height="17"/>
    </entry>
    <entry id="4" name="hsa:673" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:673">
        <graphics name="BRAF, B-RAF1, BRAF1, NS7, RAFB1" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="447" y="186" width="46" height="17"/>
    </entry>
    <entry id="5" name="hsa:5594 hsa:5595" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:5594+hsa:5595">
        <graphics name="MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="602" y="309" width="46" height="17"/>
    </entry>
    <entry id="6" name="hsa:5604 hsa:5605" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:5604+hsa:5605">
        <graphics name="MAP2K1, MAPKK1, MEK1, MKK1, PRKMK1..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="525" y="309" width="46" height="17"/>
    </entry>
    <entry id="7" name="hsa:5468 hsa:7849" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:5468+hsa:7849">
        <graphics name="PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="708" y="363" width="46" height="17"/>
    </entry>
    <entry id="8" name="hsa:7157" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:7157">
        <graphics name="TP53, BCC7, LFS1, P53, TRP53" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="772" y="599" width="46" height="17"/>
    </entry>
    <entry id="9" name="hsa:6256 hsa:6257 hsa:6258" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:6256+hsa:6257+hsa:6258">
        <graphics name="RXRA, NR2B1..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="762" y="383" width="46" height="17"/>
    </entry>
    <entry id="10" name="hsa:1499" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:1499">
        <graphics name="CTNNB1, CTNNB" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="490" y="683" width="46" height="17"/>
    </entry>
    <entry id="11" name="hsa:4609" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:4609">
        <graphics name="MYC, MRTL, bHLHe39, c-Myc" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="835" y="671" width="46" height="17"/>
    </entry>
    <entry id="12" name="hsa:999" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:999">
        <graphics name="CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="222" y="683" width="46" height="17"/>
    </entry>
    <entry id="13" name="path:hsa05216" type="map"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa05216">
        <graphics name="TITLE:Thyroid cancer" fgcolor="#000000" bgcolor="#FFFFFF"
             type="roundrectangle" x="118" y="58" width="155" height="25"/>
    </entry>
    <entry id="14" name="hsa:5594 hsa:5595" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:5594+hsa:5595">
        <graphics name="MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="602" y="167" width="46" height="17"/>
    </entry>
    <entry id="15" name="hsa:595" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:595">
        <graphics name="CCND1, BCL1, D11S287E, PRAD1, U21B31" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="835" y="694" width="46" height="17"/>
    </entry>
    <entry id="16" name="hsa:5604 hsa:5605" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:5604+hsa:5605">
        <graphics name="MAP2K1, MAPKK1, MEK1, MKK1, PRKMK1..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="525" y="167" width="46" height="17"/>
    </entry>
    <entry id="17" name="hsa:673" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:673">
        <graphics name="BRAF, B-RAF1, BRAF1, NS7, RAFB1" fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="447" y="151" width="46" height="17"/>
    </entry>
    <entry id="18" name="hsa:3265 hsa:3845 hsa:4893" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:3265+hsa:3845+hsa:4893">
        <graphics name="HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="369" y="150" width="46" height="17"/>
    </entry>
    <entry id="19" name="hsa:5979 hsa:8030 hsa:8031" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:5979+hsa:8030+hsa:8031">
        <graphics name="RET, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="278" y="118" width="46" height="17"/>
    </entry>
    <entry id="20" name="hsa:10342 hsa:4914 hsa:7170 hsa:7175" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:10342+hsa:4914+hsa:7170+hsa:7175">
        <graphics name="TFG, HMSNP, TF6, TRKT3..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="222" y="165" width="46" height="17"/>
    </entry>
    <entry id="21" name="hsa:51176 hsa:6932 hsa:6934 hsa:83439" type="gene"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa:51176+hsa:6932+hsa:6934+hsa:83439">
        <graphics name="LEF1, LEF-1, TCF10, TCF1ALPHA, TCF7L3..." fgcolor="#000000" bgcolor="#BFFFBF"
             type="rectangle" x="722" y="683" width="46" height="17"/>
    </entry>
    <entry id="22" name="path:hsa04010" type="map"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa04010">
        <graphics name="MAPK signaling pathway" fgcolor="#000000" bgcolor="#FFFFFF"
             type="roundrectangle" x="568" y="238" width="103" height="34"/>
    </entry>
    <entry id="23" name="path:hsa03320" type="map"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa03320">
        <graphics name="PPAR signaling pathway" fgcolor="#000000" bgcolor="#FFFFFF"
             type="roundrectangle" x="485" y="395" width="103" height="34"/>
    </entry>
    <entry id="24" name="path:hsa04115" type="map"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa04115">
        <graphics name="p53 signaling pathway" fgcolor="#000000" bgcolor="#FFFFFF"
             type="roundrectangle" x="775" y="558" width="103" height="34"/>
    </entry>
    <entry id="25" name="path:hsa04520" type="map"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa04520">
        <graphics name="Adherens junction" fgcolor="#000000" bgcolor="#FFFFFF"
             type="roundrectangle" x="403" y="726" width="103" height="34"/>
    </entry>
    <entry id="26" name="path:hsa04310" type="map"
        link="http://www.kegg.jp/dbget-bin/www_bget?hsa04310">
        <graphics name="Wnt signaling pathway" fgcolor="#000000" bgcolor="#FFFFFF"
             type="roundrectangle" x="577" y="726" width="103" height="34"/>
    </entry>
    <relation entry1="19" entry2="18" type="PPrel">
        <subtype name="indirect effect" value="..&gt;"/>
    </relation>
    <relation entry1="20" entry2="18" type="PPrel">
        <subtype name="indirect effect" value="..&gt;"/>
    </relation>
    <relation entry1="18" entry2="17" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
    </relation>
    <relation entry1="17" entry2="16" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
        <subtype name="phosphorylation" value="+p"/>
    </relation>
    <relation entry1="4" entry2="16" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
        <subtype name="phosphorylation" value="+p"/>
    </relation>
    <relation entry1="16" entry2="14" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
        <subtype name="phosphorylation" value="+p"/>
    </relation>
    <relation entry1="3" entry2="6" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
        <subtype name="phosphorylation" value="+p"/>
    </relation>
    <relation entry1="6" entry2="5" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
        <subtype name="phosphorylation" value="+p"/>
    </relation>
    <relation entry1="1" entry2="3" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
    </relation>
    <relation entry1="7" entry2="9" type="PPrel">
        <subtype name="binding/association" value="---"/>
    </relation>
    <relation entry1="10" entry2="12" type="PPrel">
        <subtype name="dissociation" value="-+-"/>
    </relation>
    <relation entry1="10" entry2="21" type="PPrel">
        <subtype name="activation" value="--&gt;"/>
    </relation>
    <relation entry1="21" entry2="11" type="GErel">
        <subtype name="expression" value="--&gt;"/>
    </relation>
    <relation entry1="21" entry2="15" type="GErel">
        <subtype name="expression" value="--&gt;"/>
    </relation>
</pathway>
