+D Chaperone Subcellular location
%
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Chaperones and folding catalysts
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AHeat shock proteins
B HSP110
C K09485 HSP110; heat shock protein 110kDa Cytoplasm
C K09486 HYOU1; hypoxia up-regulated 1 Endoplasmic reticulum
B HSP100
C K03694 clpA; ATP-dependent Clp protease ATP-binding subunit ClpA
C K03695 clpB; ATP-dependent Clp protease ATP-binding subunit ClpB Cytoplasm
C K03696 clpC; ATP-dependent Clp protease ATP-binding subunit ClpC
C K03697 clpE; ATP-dependent Clp protease ATP-binding subunit ClpE
C K04086 clpL; ATP-dependent Clp protease ATP-binding subunit ClpL
C K03544 clpX, CLPX; ATP-dependent Clp protease ATP-binding subunit ClpX Mitochondria
C K03667 hslU; ATP-dependent HslUV protease ATP-binding subunit HslU
B HSP90
C K04079 htpG, HSP90A; molecular chaperone HtpG Cytoplasm
C K09487 HSP90B, TRA1; heat shock protein 90kDa beta Endoplasmic reticulum
C K09488 TRAP1, HSP75; TNF receptor-associated protein 1 Mitochondria
B HSP70 / DNAK
C K03283 HSPA1_8; heat shock 70kDa protein 1/8 Cytoplasm
C K09489 HSPA4; heat shock 70kDa protein 4
C K09490 HSPA5, BIP; heat shock 70kDa protein 5 Endoplasmic reticulum
C K09491 STCH; stress 70 protein chaperone microsome-associated 60kDa protein Endoplasmic reticulum
C K04043 dnaK; molecular chaperone DnaK Mitochondria
C K04044 hscA; molecular chaperone HscA
C K04045 hscC; molecular chaperone HscC
C K04046 yegD; hypothetical chaperone protein
B HSP60 / Chaperonin
C K09492 MKKS; McKusick-Kaufman syndrome protein Cytoplasm
C K09493 CCT1, TCP1; T-complex protein 1 subunit alpha Cytoplasm
C K09494 CCT2; T-complex protein 1 subunit beta Cytoplasm
C K09495 CCT3, TRIC5; T-complex protein 1 subunit gamma Cytoplasm
C K09496 CCT4; T-complex protein 1 subunit delta Cytoplasm
C K09497 CCT5; T-complex protein 1 subunit epsilon Cytoplasm
C K09498 CCT6; T-complex protein 1 subunit zeta Cytoplasm
C K09499 CCT7; T-complex protein 1 subunit eta Cytoplasm
C K09500 CCT8; T-complex protein 1 subunit theta Cytoplasm
C K04077 groEL, HSPD1; chaperonin GroEL Mitochondria
B HSP47
C K09501 SERPINH1, HSP47; serpin peptidase inhibitor, clade H, member 1 Endoplasmic reticulum
B HSP40 / DNAJ
C K09502 DNAJA1; DnaJ homolog subfamily A member 1 Cytoplasm
C K09503 DNAJA2; DnaJ homolog subfamily A member 2 Cytoplasm
C K09504 DNAJA3; DnaJ homolog subfamily A member 3 Mitochondria
C K09505 DNAJA4; DnaJ homolog subfamily A member 4 Cytoplasm
C K09506 DNAJA5; DnaJ homolog subfamily A member 5
C K09507 DNAJB1; DnaJ homolog subfamily B member 1 Cytoplasm
C K09508 DNAJB2; DnaJ homolog subfamily B member 2 Cytoplasm
C K09509 DNAJB3; DnaJ homolog subfamily B member 3 Cytoplasm
C K09510 DNAJB4; DnaJ homolog subfamily B member 4
C K09511 DNAJB5; DnaJ homolog subfamily B member 5 Cytoplasm
C K09512 DNAJB6; DnaJ homolog subfamily B member 6 Cytoplasm
C K09513 DNAJB7; DnaJ homolog subfamily B member 7 Cytoplasm
C K09514 DNAJB8; DnaJ homolog subfamily B member 8 Cytoplasm
C K09515 DNAJB9; DnaJ homolog subfamily B member 9 Endoplasmic reticulum
C K09517 DNAJB11; DnaJ homolog subfamily B member 11 Endoplasmic reticulum
C K09518 DNAJB12; DnaJ homolog subfamily B member 12 Cytoplasm
C K09519 DNAJB13; DnaJ homolog subfamily B member 13
C K09520 DNAJB14; DnaJ homolog subfamily B member 14
C K09521 DNAJC1; DnaJ homolog subfamily C member 1 Endoplasmic reticulum
C K09522 DNAJC2; DnaJ homolog subfamily C member 2 Cytoplasm
C K09523 DNAJC3; DnaJ homolog subfamily C member 3 Endoplasmic reticulum
C K09524 DNAJC4; DnaJ homolog subfamily C member 4 Cytoplasm
C K09525 DNAJC5; DnaJ homolog subfamily C member 5 Cytoplasm
C K09526 DNAJC6; DnaJ homolog subfamily C member 6 Cytoplasm
C K09527 DNAJC7; DnaJ homolog subfamily C member 7 Cytoplasm
C K09528 DNAJC8; DnaJ homolog subfamily C member 8
C K09529 DNAJC9; DnaJ homolog subfamily C member 9
C K09530 DNAJC10; DnaJ homolog subfamily C member 10 Endoplasmic reticulum
C K09531 DNAJC11; DnaJ homolog subfamily C member 11
C K09532 DNAJC12; DnaJ homolog subfamily C member 12
C K09533 DNAJC13; DnaJ homolog subfamily C member 13
C K09534 DNAJC14; DnaJ homolog subfamily C member 14 Endoplasmic reticulum
C K09535 DNAJC15; DnaJ homolog subfamily C member 15
C K09536 DNAJC16; DnaJ homolog subfamily C member 16
C K09537 DNAJC17; DnaJ homolog subfamily C member 17
C K09538 DNAJC18; DnaJ homolog subfamily C member 18
C K09539 DNAJC19; DnaJ homolog subfamily C member 19
C K09540 SEC63; translocation protein SEC63 Endoplasmic reticulum
C K03686 dnaJ; molecular chaperone DnaJ
C K05516 cbpA; curved DNA-binding protein
C K05801 djlA; DnaJ like chaperone protein
C K04082 hscB, HSCB, HSC20; molecular chaperone HscB
B HSP33
C K04083 hslO; molecular chaperone Hsp33
B HSP24
C K03687 GRPE; molecular chaperone GrpE Mitochondria
B HSP20
C K09541 CRYAA; crystallin, alpha A Cytoplasm
C K09542 CRYAB; crystallin, alpha B Cytoplasm
C K04455 HSPB1; heat shock protein beta-1 Cytoplasm
C K09543 HSPB2; heat shock protein beta-2 Cytoplasm
C K09544 HSPB3; heat shock protein beta-3 Cytoplasm
C K09545 HSPB6; heat shock protein beta-6
C K09546 HSPB7; heat shock protein beta-7 Cytoplasm
C K08879 HSPB8; heat shock protein beta-8
C K09547 HSPB9; heat shock protein beta-9
C K13993 HSP20; HSP20 family protein
C K04080 ibpA; molecular chaperone IbpA
C K04081 ibpB; molecular chaperone IbpB
B HSP15
C K04762 hslR; ribosome-associated heat shock protein Hsp15
B HSP10
C K04078 groES, HSPE1; chaperonin GroES Mitochondria
B GimC
C K09548 PFDN1; prefoldin subunit 1 Cytoplasm
C K09549 PFDN2; prefoldin subunit 2 Cytoplasm
C K09550 PFDN4; prefoldin subunit 4 Cytoplasm
C K04797 pfdA, PFDN5; prefoldin alpha subunit Cytoplasm
C K04798 pfdB, PFDN6; prefoldin beta subunit Cytoplasm
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AOther chaperones and cochaperones
B Calnexin / calreticulin
C K08054 CANX; calnexin Endoplasmic reticulum
C K08057 CALR; calreticulin Endoplasmic reticulum
C K09551 CLGN; calmegin Endoplasmic reticulum
B DegP / HtrA
C K08784 HTRA1, PRSS11; HtrA serine peptidase 1 [EC:3.4.21.-] Cytoplasm
C K08669 HTRA2, PRSS25; HtrA serine peptidase 2 [EC:3.4.21.108] Cytoplasm
C K08785 HTRA3; HtrA serine peptidase 3 [EC:3.4.21.-] Cytoplasm
C K08786 HTRA4; HtrA serine peptidase 4 [EC:3.4.21.-] Cytoplasm
C K04771 degP, htrA; serine protease Do [EC:3.4.21.107]
B AAA proteases
C K09552 SPG7; spastic paraplegia 7 [EC:3.4.24.-] Mitochondria
C K08956 AFG3; AFG3 family protein [EC:3.4.24.-] Mitochondria
C K03798 ftsH, hflB; cell division protease FtsH [EC:3.4.24.-]
B PapD
C K02108 ATPF0A, atpB; F-type H+-transporting ATPase subunit a [EC:3.6.3.14]
C K07346 fimC; fimbrial chaperone protein
B SecB
C K03071 secB; preprotein translocase subunit SecB
B Sti1 / p60
C K09553 STIP1; stress-induced-phosphoprotein 1 Cytoplasm
B Cdc37 / p50
C K09554 CDC37; cell division cycle protein 37 Cytoplasm
B BAG
C K09555 BAG1; BCL2-associated athanogene 1 Cytoplasm
C K09556 BAG2; BCL2-associated athanogene 2 Cytoplasm
C K09557 BAG3; BCL2-associated athanogene 3 Cytoplasm
C K09558 BAG4; BCL2-associated athanogene 4 Cytoplasm
C K09559 BAG5; BCL2-associated athanogene 5 Cytoplasm
B Others
C K09560 ST13; suppressor of tumorigenicity protein 13 Cytoplasm
C K09561 STUB1, CHIP; STIP1 homology and U-box containing protein 1 [EC:6.3.2.19] Cytoplasm
C K09562 HSPBP1; hsp70-interacting protein Cytoplasm
C K14214 NFKBID; NF-kappa-B inhibitor delta Nucleus
C K14242 NFKBIZ; NF-kappa-B inhibitor zeta Nucleus
C K09256 NFKBIL1; NF-kappa-B inhibitor-like protein 1 Nucleus
C K09258 BCL3; B-cell CLL/lymphoma protein 3 Nucleus
C K16729 CHORDC1, CHP1; cysteine and histidine-rich domain-containing protein 1
C K16735 ITGB1BP2; integrin beta-1-binding protein 2
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AIntramolecular chaperones
B Subtilisin family
C K01342 aprE; subtilisin [EC:3.4.21.62]
C K13274 wprA; cell wall-associated protease [EC:3.4.21.-]
C K08651 E3.4.21.66; thermitase [EC:3.4.21.66]
C K13276 bpr; bacillopeptidase F [EC:3.4.21.-]
C K01361 E3.4.21.96; lactocepin [EC:3.4.21.96]
C K08652 C5AP, scpA, scpB; C5a peptidase [EC:3.4.21.110]
C K01336 E3.4.21.48; cerevisin [EC:3.4.21.48]
C K13275 isp; major intracellular serine protease [EC:3.4.21.-]
C K14644 OSW3, RRT12; subtilase-type proteinase RRT12 [EC:3.4.21.-]
C K08653 MBTPS1; membrane-bound transcription factor site-1 protease [EC:3.4.21.112]
C K14645 K14645; serine protease [EC:3.4.21.-]
C K01341 E3.4.21.61; kexin [EC:3.4.21.61]
C K01349 FURIN, PCSK3; furin [EC:3.4.21.75]
C K01359 PCSK1; proprotein convertase subtilisin/kexin type 1 [EC:3.4.21.93]
C K01360 PCSK2; proprotein convertase subtilisin/kexin type 2 [EC:3.4.21.94]
C K08671 PCSK4; proprotein convertase subtilisin/kexin type 4 [EC:3.4.21.-]
C K08654 PCSK5; proprotein convertase subtilisin/kexin type 5 [EC:3.4.21.-]
C K08672 PCSK6; proprotein convertase subtilisin/kexin type 6 [EC:3.4.21.-]
C K08673 PCSK7; proprotein convertase subtilisin/kexin type 7 [EC:3.4.21.-]
C K13050 PCSK9; proprotein convertase subtilisin/kexin type 9 [EC:3.4.21.-]
C K01279 TPP1, CLN2; tripeptidyl-peptidase I [EC:3.4.14.9]
C K01280 TPP2; tripeptidyl-peptidase II [EC:3.4.14.10]
C K14647 vpr; minor extracellular serine protease Vpr [EC:3.4.21.-]
C K13277 epr; minor extracellular protease Epr [EC:3.4.21.-]
C K14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]
B Papain family
C K01363 CTSB; cathepsin B [EC:3.4.22.1]
C K01275 CTSC; cathepsin C [EC:3.4.14.1]
C K01371 CTSK; cathepsin K [EC:3.4.22.38]
C K01365 CTSL; cathepsin L [EC:3.4.22.15]
C K01368 CTSS; cathepsin S [EC:3.4.22.27]
C K08571 E3.4.22.51; cruzipain [EC:3.4.22.51]
C K06000 E3.4.22.2; papain [EC:3.4.22.2]
B Other peptidases
C K08779 CPA1; carboxypeptidase A1 [EC:3.4.17.1]
C K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
C K01327 ELANE; leukocyte elastase [EC:3.4.21.37]
C K08603 E3.4.24.27; thermolysin [EC:3.4.24.27]
C K06009 E3.4.23.41; yapsin 1 [EC:3.4.23.41]
B Others
C K10948 hlyA; hemolysin
C K04667 INHB; inhibin, beta
C K09782 AREG; amphiregulin
C K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
C K02582 NGFB; nerve growth factor, beta
C K01229 LCT; lactase-phlorizin hydrolase [EC:3.2.1.108 3.2.1.62]
C K13375 TGFB1; transforming growth factor beta-1
C K03900 VWF; von Willebrand factor
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AProtein folding catalysts
B Peptidyl prolyl isomerase
C Cyclophilin
D K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8] Cytoplasm
D K03768 PPIB, ppiB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8] Endoplasmic reticulum
D K09563 PPIC, CYPC; peptidyl-prolyl isomerase C (cyclophilin C) [EC:5.2.1.8] Endoplasmic reticulum
D K05864 PPID, CYPD; peptidyl-prolyl isomerase D [EC:5.2.1.8] Mitochondria
D K09564 PPIE; peptidyl-prolyl isomerase E (cyclophilin E) [EC:5.2.1.8]
D K09565 PPIF; peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]
D K09566 PPIG; peptidyl-prolyl isomerase G (cyclophilin G) [EC:5.2.1.8]
D K09567 PPIH, CYPH; peptidyl-prolyl isomerase H (cyclophilin H) [EC:5.2.1.8]
D K12738 PPIAL4; peptidylprolyl cis-trans isomerase A-like 4 [EC:5.2.1.8]
D K12733 PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [EC:5.2.1.8]
D K10598 PPIL2, CYC4, CHP60; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]
D K12734 PPIL3; peptidyl-prolyl cis-trans isomerase-like 3 [EC:5.2.1.8]
D K12735 PPIL4; peptidyl-prolyl cis-trans isomerase-like 4 [EC:5.2.1.8]
D K12739 PPIL6; peptidyl-prolyl cis-trans isomerase-like 6 [EC:5.2.1.8]
D K12736 PPWD1; peptidylprolyl isomerase domain and WD repeat-containing protein 1 [EC:5.2.1.8]
D K12737 SDCCAG10; peptidyl-prolyl cis-trans isomerase SDCCAG10 [EC:5.2.1.8]
D K12740 NKTR; NK-tumor recognition protein
D K12172 RANBP2, NUP358; E3 SUMO-protein ligase RanBP2
D K03770 ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8]
C FKBP
D K09568 FKBP1; FK506-binding protein 1 [EC:5.2.1.8] Cytoplasm
D K09569 FKBP2; FK506-binding protein 2 [EC:5.2.1.8] Endoplasmic reticulum
D K09570 FKBP3; FK506-binding protein 3 [EC:5.2.1.8] Cytoplasm
D K09571 FKBP4_5; FK506-binding protein 4/5 [EC:5.2.1.8] Cytoplasm
D K09572 FKBP6; FK506-binding protein 6 [EC:5.2.1.8]
D K09573 FKBP7; FK506-binding protein 7 [EC:5.2.1.8]
D K09574 FKBP8; FK506-binding protein 8 [EC:5.2.1.8]
D K09575 FKBP9_10; FK506-binding protein 9/10 [EC:5.2.1.8]
D K09576 FKBP11; FK506-binding protein 11 [EC:5.2.1.8]
D K09577 FKBP14; FK506-binding protein 14 [EC:5.2.1.8]
D K03772 fkpA; FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [EC:5.2.1.8]
D K03773 fklB; FKBP-type peptidyl-prolyl cis-trans isomerase FklB [EC:5.2.1.8]
D K03774 slpA; FKBP-type peptidyl-prolyl cis-trans isomerase SlpA [EC:5.2.1.8]
D K03775 slyD; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8]
D K07533 prsA; foldase protein PrsA [EC:5.2.1.8]
C Parvulin
D K09578 PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [EC:5.2.1.8] Cytoplasm
D K09579 PIN4; peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 [EC:5.2.1.8] Cytoplasm
D K03769 ppiC; peptidyl-prolyl cis-trans isomerase C [EC:5.2.1.8]
D K03771 surA; peptidyl-prolyl cis-trans isomerase SurA [EC:5.2.1.8]
B Protein disulfide isomerase
C K03671 trxA; thioredoxin 1 Endoplasmic reticulum
C K03672 trxC; thioredoxin 2 [EC:1.8.1.8]
C K05838 ybbN; putative thioredoxin Endoplasmic reticulum
C K03674 grxA; glutaredoxin 1
C K03675 grxB; glutaredoxin 2
C K03676 grxC, GLRX, GLRX2; glutaredoxin 3 Endoplasmic reticulum
C K07390 grxD, GLRX5; monothiol glutaredoxin Endoplasmic reticulum
C K09580 PDIA1, P4HB; protein disulfide-isomerase A1 [EC:5.3.4.1]
C K09581 PDIA2; protein disulfide isomerase family A, member 2 [EC:5.3.4.1] Endoplasmic reticulum
C K08056 PDIA3, GRP58; protein disulfide isomerase family A, member 3 [EC:5.3.4.1] Endoplasmic reticulum
C K09582 PDIA4, ERP72; protein disulfide-isomerase A4 [EC:5.3.4.1] Endoplasmic reticulum
C K09583 PDIA5; protein disulfide isomerase family A, member 5 [EC:5.3.4.1] Endoplasmic reticulum
C K09584 PDIA6, TXNDC7; protein disulfide-isomerase A6 [EC:5.3.4.1] Endoplasmic reticulum
C K13996 EPS1; protein disulfide-isomerase [EC:5.3.4.1] Endoplasmic reticulum
C K13984 TXNDC5, ERP46; thioredoxin domain-containing protein 5 Endoplasmic reticulum
C K09585 TXNDC10; thioredoxin domain-containing protein 10 [EC:5.3.4.1]
C K09586 ERP29; endoplasmic reticulum protein 29 Endoplasmic reticulum
C K03673 dsbA; thiol:disulfide interchange protein DsbA
C K03611 dsbB; disulfide bond formation protein DsbB
C K03981 dsbC; thiol:disulfide interchange protein DsbC [EC:5.3.4.1]
C K04084 dsbD; thiol:disulfide interchange protein DsbD [EC:1.8.1.8]
C K02199 ccmG, dsbE; cytochrome c biogenesis protein CcmG, thiol:disulfide interchange protein DsbE
C K03805 dsbG; thiol:disulfide interchange protein DsbG
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: January 25, 2013