+F Repair protein
#
DNA Repair and Recombination Proteins
#
!
AEukaryotic Type
B SSBR (single strand breaks repair)
C Direct repair
D K00567 E2.1.1.63, MGMT, ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D K10859 ALKBH2; alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 [EC:1.14.11.-]
D K10860 ALKBH3, DEPC1; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 [EC:1.14.11.-]
D K02295 CRY; cryptochrome
D K01669 E4.1.99.3, phrB; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E K03648 UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27]
E K10861 UDG2, CCNO; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E K03649 MUG, TDG; TDG/mug DNA glycosylase family protein [EC:3.2.2.-]
E K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.-]
E K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E K10569 NEIL3; endonuclease VIII-like 3
E K10773 NTH; endonuclease III [EC:4.2.99.18]
D AP endonucleases
E K10771 APEX1; AP endonuclease 1 [EC:4.2.99.18]
E K10772 APEX2; AP endonuclease 2 [EC:4.2.99.18]
D Long Patch-BER factors
E DNA polymerase delta complex
F K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F K02328 POLD2; DNA polymerase delta subunit 2
F K03504 POLD3; DNA polymerase delta subunit 3
F K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F K02324 POLE1; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E K04802 PCNA; proliferating cell nuclear antigen
E K04799 FEN1, RAD2; flap endonuclease-1 [EC:3.-.-.-]
E K10747 LIG1; DNA ligase 1 [EC:6.5.1.1]
D Short Patch-BER factors
E K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E K10803 XRCC1; DNA-repair protein XRCC1
E K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E K10863 APTX; aprataxin [EC:3.-.-.-]
E K13295 APLF; aprataxin and PNK-like factor [EC:4.2.99.18]
E K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E K08075 E3.1.3.32; polynucleotide 3'-phosphatase [EC:3.1.3.32]
E K10802 HMGB1; high mobility group protein B1
E K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E K10798 PARP; poly [ADP-ribose] polymerase [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F K10838 XPC; xeroderma pigmentosum group C-complementing protein
F K10839 RAD23, HR23; UV excision repair protein RAD23
F K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F K03868 RBX1, ROC1; RING-box protein 1
F K10609 CUL4; cullin 4
F K10610 DDB1; DNA damage-binding protein 1
F K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
F K15082 RAD7; DNA repair protein RAD7
F K15083 RAD16; DNA repair protein RAD16
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F K03006 RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F K03010 RPB2, POLR2B; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F K03011 RPB3, POLR2C; DNA-directed RNA polymerase II subunit RPB3
F K03012 RPB4, POLR2D; DNA-directed RNA polymerase II subunit RPB4
F K03013 RPB5, POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F K03014 RPB6, POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F K03015 RPB7, POLR2G; DNA-directed RNA polymerase II subunit RPB7
F K03016 RPB8, POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F K03017 RPB9, POLR2I; DNA-directed RNA polymerase II subunit RPB9
F K03007 RPB10, POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F K03008 RPB11, POLR2J; DNA-directed RNA polymerase II subunit RPB11
F K03009 RPB12, POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F K03868 RBX1, ROC1; RING-box protein 1
F K10609 CUL4; cullin 4
F K10610 DDB1; DNA damage-binding protein 1
F K10570 ERCC8, CKN1, CSA; DNA excision repair protein ERCC-8
E Other TCR factor
F K10841 ERCC6, CSB, RAD26; DNA excision repair protein ERCC-6
D TFIIH complex
E K10843 ERCC3, XPB; DNA excision repair protein ERCC-3 [EC:3.6.4.12]
E K10844 ERCC2, XPD; DNA excision repair protein ERCC-2 [EC:3.6.4.12]
E K03141 TFIIH1, GTF2H1, TFB1; transcription initiation factor TFIIH subunit 1
E K03142 TFIIH2, GTF2H2, SSL1; transcription initiation factor TFIIH subunit 2
E K03143 TFIIH3, GTF2H3, TFB4; transcription initiation factor TFIIH subunit 3
E K03144 TFIIH4, GTF2H4, TFB2; transcription initiation factor TFIIH subunit 4
E K10845 TTDA, GTF2H5, TFB5; TFIIH basal transcription factor complex TTD-A subunit
E K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E K06634 CCNH; cyclin H
E K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E K07466 RFA1, RPA1, rpa; replication factor A1
E K10739 RFA2, RPA2; replication factor A2
E K10740 RPA3; replication factor A3
E K10741 RPA4; replication factor A4
D Other NER factors
E K10847 XPA; DNA-repair protein complementing XP-A cells
E K10849 ERCC1; DNA excision repair protein ERCC-1
E K10848 ERCC4, XPF; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E K10846 ERCC5, XPG, RAD2; DNA excision repair protein ERCC-5
E K10747 LIG1; DNA ligase 1 [EC:6.5.1.1]
E K15075 MET18, MMS19; DNA repair/transcription protein MET18/MMS19
E K03869 CUL3; cullin 3
E K10612 CUL5; cullin 5
E K03872 TCEB1; transcription elongation factor B, polypeptide 1
E K03873 TCEB2; transcription elongation factor B, polypeptide 2
E K15076 TCEB3, ELOA; transcription elongation factor B, polypeptide 3
E K15077 ELA1; elongin-A
C MMR (mismatch exicision repair)
D Mismatch and loop recognition factors
E K08735 MSH2; DNA mismatch repair protein MSH2
E K08736 MSH3; DNA mismatch repair protein MSH3
E K08737 MSH6; DNA mismatch repair protein MSH6
D MutS homologs specialized for meiosis
E K08740 MSH4; DNA mismatch repair protein MSH4
E K08741 MSH5; DNA mismatch repair protein MSH5
D MutL homologs
E K10864 PMS1; DNA mismatch repair protein PMS1
E K08734 MLH1; DNA mismatch repair protein MLH1
E K10858 PMS2; DNA mismatch repair protein PMS2
E K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E K02328 POLD2; DNA polymerase delta subunit 2
E K03504 POLD3; DNA polymerase delta subunit 3
E K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E K07466 RFA1, RPA1, rpa; replication factor A1
E K10739 RFA2, RPA2; replication factor A2
E K10740 RPA3; replication factor A3
E K10741 RPA4; replication factor A4
D RFC (replication factor C)
E K10754 RFC1; replication factor C subunit 1
E K10755 RFC2_4; replication factor C subunit 2/4
E K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E K04802 PCNA; proliferating cell nuclear antigen
E K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E K10802 HMGB1; high mobility group protein B1
E K10747 LIG1; DNA ligase 1 [EC:6.5.1.1]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E K10865 MRE11; double-strand break repair protein MRE11
E K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E K10867 NBN, NBS1; nijmegen breakage syndrome protein 1
E K10868 XRS2; DNA repair protein XRS2
D RecA family proteins
E K04482 RAD51; DNA repair protein RAD51
E K10869 RAD51L1, RAD51B; RAD51-like protein 1
E K10870 RAD51L2, RAD51C; RAD51-like protein 2
E K10871 RAD51L3, RAD51D; RAD51-like protein 3
E K10879 XRCC2; DNA-repair protein XRCC2
E K10880 XRCC3; DNA-repair protein XRCC3
E K10872 DMC1; meiotic recombination protein DMC1
E K10957 RAD55; DNA repair protein RAD55
E K10958 RAD57; DNA repair protein RAD57
D Rad52 family proteins
E K10873 RAD52; DNA repair and recombination protein RAD52
E K10874 RDM1, RAD52B; RAD52 motif-containing protein 1
E K10959 RAD59; DNA repair protein RAD59
D Rad54 family proteins
E K10875 RAD54L, RAD54; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-]
E K10876 RAD54L2; RAD54-like protein 2 [EC:3.6.4.12]
E K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:3.6.4.-]
D RecQ family DNA helicases
E K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:3.6.4.12]
E K10900 WRN, RECQL2; werner syndrome ATP-dependent helicase [EC:3.6.4.12]
E K10901 BLM, RECQL3, SGS1; bloom syndrome protein [EC:3.6.4.12]
E K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:3.6.4.12]
E K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:3.6.4.12]
D Bloom's syndrome complex (BTR)
E K10901 BLM, RECQL3, SGS1; bloom syndrome protein [EC:3.6.4.12]
E K03165 TOP3; DNA topoisomerase III [EC:5.99.1.2]
E K10990 RMI1, BRAP75; RecQ-mediated genome instability protein 1
E K15364 NCE4, RMI1; RecQ-mediated genome instability protein 1
E K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E K07466 RFA1, RPA1, rpa; replication factor A1
E K10739 RFA2, RPA2; replication factor A2
E K10740 RPA3; replication factor A3
E K10741 RPA4; replication factor A4
D Protein phosphatase 4
E K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D Other HR factors
E K10605 BRCA1; breast cancer type 1 susceptibility protein
E K08775 BRCA2, FANCD1; breast cancer 2 susceptibility protein
E K10882 EME1, MMS4; crossover junction endonuclease EME1 [EC:3.1.22.-]
E K10883 EME2; crossover junction endonuclease EME2
E K15271 HFM1, MER3; ATP-dependent DNA helicase HFM1/MER3 [EC:3.6.4.12]
E K14635 MPH1; ATP-dependent DNA helicase MPH1 [EC:3.6.4.12]
E K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E K10881 SHFM1, DSS1; 26 proteasome complex subunit DSS1
E K10878 SPO11; meiotic recombination protein SPO11
E K10998 CSM3, SWI3; replication fork protection complex subunit Csm3/Swi3
E K10991 SAE3, SWI5; DNA repair protein Swi5/Sae3
E K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E K10484 BTBD12, SLX4; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E K15079 SLX4; structure-specific endonuclease subunit SLX4
E K15080 SAW1; single-strand annealing weakened protein 1
E K15338 GEN1, GEN; flap endonuclease GEN [EC:3.1.-.-]
E K15339 YEN1; holliday junction resolvase YEN1 [EC:3.1.-.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E K10884 XRCC6, KU70, G22P1; ATP-dependent DNA helicase 2 subunit 1
E K10885 XRCC5, KU80, G22P2; ATP-dependent DNA helicase 2 subunit 2
E K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E K10865 MRE11; double-strand break repair protein MRE11
E K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E K10868 XRS2; DNA repair protein XRS2
D DNA Ligase 4 complex
E K10777 LIG4, DNL4; DNA ligase 4 [EC:6.5.1.1]
E K10886 XRCC4; DNA-repair protein XRCC4
E K10980 NHEJ1, XLF; non-homologous end-joining factor 1
E K10982 LIF1; ligase-interacting factor 1
E K10983 NEJ1, LIF2; non-homologous end-joining protein 1
D X-family DNA polymerases
E K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E K00977 E2.7.7.31, DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E K10981 POL4; DNA polymerase IV [EC:2.7.7.7]
D Other NHEJ factors
E K10863 APTX; aprataxin [EC:3.-.-.-]
E K13295 APLF; aprataxin and PNK-like factor [EC:4.2.99.18]
E K10887 DCLRE1C, ARTEMIS, SCIDA; DNA cross-link repair 1C protein [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E K10888 FANCA; fanconi anemia group A protein
E K10889 FANCB; fanconi anemia group B protein
E K10890 FANCC; fanconi anemia group C protein
E K10892 FANCE; fanconi anemia group E protein
E K10893 FANCF; fanconi anemia group F protein
E K10894 FANCG; fanconi anemia group G protein
E K10606 FANCL, PHF9; E3 ubiquitin-protein ligase FANCL [EC:6.3.2.19]
E K10896 FANCM; fanconi anemia group M protein
E K10898 FAAP24; fanconi anemia-associated protein
E K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E K06054 HES1; hairy and enhancer of split 1
E K11511 APITD1, CENPS, MHF1; centromere protein S
E K15360 STRA13, CENPX, MHF2; centromere protein X
E K13960 UBE2T, HSPC150; ubiquitin-conjugating enzyme E2 T [EC:6.3.2.19]
D Bloom's syndrome complex (BTR)
E K10901 BLM, RECQL3, SGS1; bloom syndrome protein [EC:3.6.4.12]
E K03165 TOP3; DNA topoisomerase III [EC:5.99.1.2]
E K10990 RMI1, BRAP75; RecQ-mediated genome instability protein 1
E K15364 NCE4, RMI1; RecQ-mediated genome instability protein 1
E K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E K10891 FANCD2; fanconi anemia group D2 protein
E K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E K10605 BRCA1; breast cancer type 1 susceptibility protein
E K08775 BRCA2, FANCD1; breast cancer 2 susceptibility protein
E K15362 BRIP1, BACH1, FANCJ; fanconi anemia group J protein [EC:3.6.4.12]
E K10897 PALB2, FANCN; partner and localizer of BRCA2
D Other FA pathway factors
E K15363 FAN1, MTMR15; fanconi-associated nuclease 1
E K04482 RAD51; DNA repair protein RAD51
E K10870 RAD51L2, RAD51C; RAD51-like protein 2
E K11137 TELO2, TEL2; telomere length regulation protein
E K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.1.2.15]
E K15361 WDR48, UAF1; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E K15499 PPP6R1, SAPS1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E K15500 PPP6R2, SAPS2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E K15501 PPP6R3, SAPS3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D K02350 POLZ1, rev3; DNA polymerase zeta [EC:2.7.7.7]
D K03508 POLZ2, rev7; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D K10573 UBE2A, UBC2, RAD6A; ubiquitin-conjugating enzyme E2 A [EC:6.3.2.19]
D K10574 UBE2B, RAD6B; ubiquitin-conjugating enzyme E2 B [EC:6.3.2.19]
D K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:6.3.2.19]
D K15505 RAD5; DNA repair protein RAD5 [EC:3.6.4.-]
D K15711 SMARCA3, HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:3.6.4.- 6.3.2.19]
D K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D K10580 UBE2N, BLU, UBC13; ubiquitin-conjugating enzyme E2 N [EC:6.3.2.19]
B Check point factors
C Rad9-Hus1-Rad1 complex
D K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D K10903 HUS1; HUS1 checkpoint protein
D K10996 HUS1B; checkpoint protein HUS1B
D K02830 HRAD1, RAD17; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D K06662 HRAD17, RAD24; cell cycle checkpoint protein
D K10755 RFC2_4; replication factor C subunit 2/4
D K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D K02830 HRAD1, RAD17; cell cycle checkpoint protein [EC:3.1.11.2]
D K02544 MEC3; G2-specific checkpoint protein
D K06663 DDC1; DNA damage checkpoint protein
C FPC (fork protection complex)
D K03155 TIMELESS; timeless
D K10904 TIPIN; TIMELESS-interacting protein
D K10997 TOF1, SWI1; replication fork protection complex subunit Tof1/Swi1
D K10998 CSM3, SWI3; replication fork protection complex subunit Csm3/Swi3
C Other check point factors
D K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D K10905 ATRIP; ATR interacting protein
D K04728 ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
D K04451 TP53, P53; tumor protein p53
D K02216 CHK1; serine/threonine-protein kinase Chk1 [EC:2.7.11.1]
D K06641 CHK2; serine/threonine-protein kinase Chk2 [EC:2.7.11.1]
D K02831 RAD53; ser/thr/tyr protein kinase RAD53 [EC:2.7.11.-]
D K02633 PER; period circadian protein
D K06661 RAD9; DNA repair protein RAD9
D K02543 MEC1; cell cycle checkpoint protein MEC1
D K15081 AMN1; antagonist of mitotic exit network protein 1
B Other factors with a suspected DNA repair function
C DNA polymerases
D K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D K03514 POLS, TRF4; DNA polymerase sigma [EC:2.7.7.7]
D K02331 POL5, MYBBP1A; DNA polymerase phi [EC:2.7.7.7]
C Nucleases
D K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D K15340 DCLRE1A, SNM1A, PSO2; DNA cross-link repair 1A protein
D K15341 DCLRE1B, SNM1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
C PSO4 complex
D K10599 PRPF19, PRP19; pre-mRNA-processing factor 19 [EC:6.3.2.19]
D K12860 CDC5L, CDC5, CEF1; pre-mRNA-splicing factor CDC5/CEF1
D K12861 BCAS2; pre-mRNA-splicing factor SPF27
D K12862 PLRG1, PRL1, PRP46; pleiotropic regulator 1
C Modulation of nucleotide pools
D K03574 MUTT, NUDT1, MTH1; 7,8-dihydro-8-oxoguanine triphosphatase [EC:3.6.1.-]
D K01520 dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23]
D K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic Type
B SSBR (single strand breaks repair)
C Direct repair
D K00567 E2.1.1.63, MGMT, ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D K13530 adaA; AraC family transcriptional regulator, regulatory protein of adaptative response / methylphosphotriester-DNA alkyltransferase methyltransferase [EC:2.1.1.-]
D K13531 adaB; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D K01669 E4.1.99.3, phrB; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D K03919 alkB; alkylated DNA repair protein [EC:1.14.11.-]
C BER (base exicision repair)
D DNA glycosylases
E K03648 UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27]
E K03649 MUG, TDG; TDG/mug DNA glycosylase family protein [EC:3.2.2.-]
E K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.-]
E K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E K10563 mutM, fpg; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E K10773 NTH; endonuclease III [EC:4.2.99.18]
D AP endonucleases
E K01142 E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2]
E K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E K05982 E3.1.21.7, nfi; deoxyribonuclease V [EC:3.1.21.7]
D RecJ
E K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E K01971 E6.5.1.1, lig; DNA ligase (ATP) [EC:6.5.1.1]
E K01972 E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E K02335 DPO1, polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E K03701 uvrA; excinuclease ABC subunit A
E K03702 uvrB; excinuclease ABC subunit B
E K03703 uvrC; excinuclease ABC subunit C
E K05984 cho; excinuclease Cho [EC:3.1.25.-]
E K03657 uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12]
E K02335 DPO1, polA; DNA polymerase I [EC:2.7.7.7]
E K01971 E6.5.1.1, lig; DNA ligase (ATP) [EC:6.5.1.1]
E K01972 E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F K13797 rpoBC; DNA-directed RNA polymerase subunit beta-beta' [EC:2.7.7.6]
F K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F K03048 rpoE; DNA-directed RNA polymerase subunit delta
F K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-]
C MMR (mismatch exicision repair)
D Mismatch and loop recognition factors
E K03555 mutS; DNA mismatch repair protein MutS
E K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
E K03573 mutH; DNA mismatch repair protein MutH
D DNA exonucleases
E K01141 E3.1.11.1, sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
E K10857 exoX; exodeoxyribonuclease X [EC:3.1.11.-]
D DNA polymerase III holoenzyme
E K02337 DPO3A1, dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E K03763 DPO3A2, polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E K02338 DPO3B, dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E K02339 DPO3C, holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E K02340 DPO3D1, holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E K02341 DPO3D2, holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E K02342 DPO3E, dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E K14159 rnhA-dnaQ; ribonuclease HI / DNA polymerase III subunit epsilon [EC:3.1.26.4 2.7.7.7]
E K02343 DPO3G, dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
E K02344 DPO3P, holD; DNA polymerase III subunit psi [EC:2.7.7.7]
E K02345 DPO3T, holE; DNA polymerase III subunit theta [EC:2.7.7.7]
D DNA ligase
E K01971 E6.5.1.1, lig; DNA ligase (ATP) [EC:6.5.1.1]
E K01972 E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E K03657 uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12]
E K03111 ssb; single-strand DNA-binding protein
E K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E K03553 recA; recombination protein RecA
E K03550 ruvA; holliday junction DNA helicase RuvA [EC:3.6.4.12]
E K03551 ruvB; holliday junction DNA helicase RuvB [EC:3.6.4.12]
E K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4]
E K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.22.4]
E K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:3.6.4.-]
E K02686 priB; primosomal replication protein N
E K04067 priC; primosomal replication protein N''
E K02317 dnaT; DNA replication protein DnaT
E K01141 E3.1.11.1, sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E K03546 sbcC; exonuclease SbcC
E K03547 sbcD; exonuclease SbcD
D RecFOR pathway proteins
E K03553 recA; recombination protein RecA
E K04485 sms, radA; DNA repair protein RadA/Sms
E K03629 recF; DNA replication and repair protein RecF
E K03655 recG; ATP-dependent DNA helicase RecG [EC:3.6.4.12]
E K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E K03584 recO; DNA repair protein RecO (recombination protein O)
E K06187 recR; recombination protein RecR
E K03631 recN; DNA repair protein RecN (Recombination protein N)
E K03700 recU; recombination protein U
E K03554 rdgC; recombination associated protein RdgC
E K03550 ruvA; holliday junction DNA helicase RuvA [EC:3.6.4.12]
E K03551 ruvB; holliday junction DNA helicase RuvB [EC:3.6.4.12]
E K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4]
D AddAB pathway proteins
E K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:3.1.-.- 3.6.4.12]
E K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:3.1.-.- 3.6.4.12]
D Other HR factor
E K15342 cas1; CRISP-associated protein Cas1
D Archaeal homologous recombinant proteins
E K04483 radA; DNA repair protein RadA
E K04484 radB; DNA repair protein RadB
E K03552 hjr; holliday junction resolvase, archaea type
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E K10979 ku; DNA end-binding protein Ku
E K01971 E6.5.1.1, lig; DNA ligase (ATP) [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F K02469 gyrA; DNA gyrase subunit A [EC:5.99.1.3]
F K02470 gyrB; DNA gyrase subunit B [EC:5.99.1.3]
F K03168 topA; DNA topoisomerase I [EC:5.99.1.2]
E Supressor
F K05787 hupA; DNA-binding protein HU-alpha
F K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F K10906 recE; exodeoxyribonuclease VIII [EC:3.1.11.-]
F K07455 recT; recombination protein RecT
F K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F K03584 recO; DNA repair protein RecO (recombination protein O)
F K06187 recR; recombination protein RecR
F K01971 E6.5.1.1, lig; DNA ligase (ATP) [EC:6.5.1.1]
E Facilitator
F K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F K04764 ihfA, himA; integration host factor subunit alpha
F K05788 ihfB, himD; integration host factor subunit beta
E Supressor
F K01141 E3.1.11.1, sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
F K03654 recQ; ATP-dependent DNA helicase RecQ [EC:3.6.4.12]
F K03701 uvrA; excinuclease ABC subunit A
F K03702 uvrB; excinuclease ABC subunit B
F K03746 hns; DNA-binding protein H-NS
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D K02346 DPO4, dinB; DNA polymerase IV [EC:2.7.7.7]
D K03502 DPO5C, umuC; DNA polymerase V
D K03503 DPO5D, umuD; DNA polymerase V [EC:3.4.21.-]
D K04479 K04479; DNA polymerase IV (archaeal DinB-like DNA polymerase) [EC:2.7.7.7]
C Other SOS response factors
D K03553 recA; recombination protein RecA
D K01356 lexA; repressor LexA [EC:3.4.21.88]
D K03631 recN; DNA repair protein RecN (Recombination protein N)
D K02336 DPO2, polB; DNA polymerase II [EC:2.7.7.7]
D K14160 imuA; protein ImuA
D K14161 imuB; protein ImuB
D K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
D K02347 dpx; DNA polymerase (family X)
C DNA helicases
D K03656 rep; ATP-dependent DNA helicase Rep [EC:3.6.4.12]
D K03658 helD; DNA helicase IV [EC:3.6.4.12]
D K03722 dinG; ATP-dependent DNA helicase DinG [EC:3.6.4.12]
D K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:3.6.4.-]
C Modulation of nucleotide pools
D K03574 MUTT, NUDT1, MTH1; 7,8-dihydro-8-oxoguanine triphosphatase [EC:3.6.1.-]
D K01520 dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23]
D K00525 E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D K00526 E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 2, 2013