Target-based Classification of Drugs

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     Remark
 G Protein-coupled receptors
   Rhodopsin family
     Acetylcholine (muscarinic)
     Adrenaline
       alpha1a-adrenergic receptor [HSA:148] [KO:K04135]
       alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
         Epinephrine [ATC:A01AD01 B02BC09 C01CA24 R01AA14 R03AA01 S01EA01]
         Etilefrine [ATC:C01CA01]
         Norepinephrine [ATC:C01CA03]
         Norfenefrine [ATC:C01CA05]
         Phenylephrine [ATC:C01CA06 R01AA04 R01AB01 R01BA03 S01FB01 S01GA05]
         Oxedrine [ATC:C01CA08 S01GA06]
         Metaraminol [ATC:C01CA09]
         Methoxamine [ATC:C01CA10]
         Midodrine [ATC:C01CA17]
         Arbutamine [ATC:C01CA22]
         Ephedrine [ATC:C01CA26 R01AA03 R01AB05 R03CA02 S01FB02]
         Prazosin [ATC:C02CA01]
         Indoramin [ATC:C02CA02]
         Trimazosin [ATC:C02CA03]
         Doxazosin [ATC:C02CA04]
         Urapidil [ATC:C02CA06]
         Ketanserin [ATC:C02KD01]
         Phentolamine [ATC:C04AB01 V03AB36]
         Tolazoline [ATC:C04AB02 M02AX02]
         Nicergoline [ATC:C04AE02]
         Phenoxybenzamine [ATC:C04AX02]
         Moxisylyte [ATC:C04AX10 G04BE06]
         Ifenprodil [ATC:C04AX28]
         Labetalol [ATC:C07AG01]
         Carvedilol [ATC:C07AG02]
         Methylergometrine [ATC:G02AB01]
         Ergot alkaloids [ATC:G02AB02]
         Ergometrine [ATC:G02AB03]
         Alfuzosin [ATC:G04CA01]
         Tamsulosin [ATC:G04CA02]
         Terazosin [ATC:G04CA03]
         Silodosin [ATC:G04CA04]
         Dihydroergotamine [ATC:N02CA01]
         Ergotamine [ATC:N02CA02]
         Levomepromazine [ATC:N05AA02]
         Sertindole [ATC:N05AE03]
         Pimozide [ATC:N05AG02]
         Clozapine [ATC:N05AH02]
         Asenapine [ATC:N05AH05]
         Olanzapine [ATC:N05AH03]
         Quetiapine [ATC:N05AH04]
           D08456  Quetiapine (INN)
           D00458  Quetiapine fumarate (JAN/USAN)
Antagonist
Antagonist
         Risperidone [ATC:N05AX08]
         Mianserin [ATC:N06AX03]
         Oxymetazoline [ATC:R01AA05 R01AB07 S01GA04]
         Tetryzoline [ATC:R01AA06 R01AB03 S01GA02]
         Xylometazoline [ATC:R01AA07 R01AB06 S01GA03]
         Naphazoline [ATC:R01AA08 R01AB02 S01GA01]
         Tramazoline [ATC:R01AA09]
         Pseudoephedrine [ATC:R01BA02]
         Dipivefrine [ATC:S01EA02]
         Dapiprazole [ATC:S01EX02]
         Amidephrine
         Amosulalol
         Arotinolol
         Bunazosin
         Bunitrolol
         Dipivefrin
         Guanadrel
         Medroxalol
         Methylephedrine
         Naftopidil
         Pelanserin
         Setiptiline
       alpha2b-adrenergic receptor [HSA:151] [KO:K04139]
       alpha2-adrenergic receptor [HSA:150 151 152] [KO:K04138 K04139 K04140]
       beta1-adrenergic receptor [HSA:153] [KO:K04141]
       beta2-adrenergic receptor [HSA:154] [KO:K04142]
       beta3-adrenergic receptor [HSA:155] [KO:K04143]
     Dopamine
       dopamine D1-receptor [HSA:1812] [KO:K04144]
       dopamine D2-receptor [HSA:1813] [KO:K04145]
         Metoclopramide [ATC:A03FA01]
         Domperidone [ATC:A03FA03]
         Bromopride [ATC:A03FA04]
         Alizapride [ATC:A03FA05]
         Clebopride [ATC:A03FA06]
         Metopimazine [ATC:A04AD05]
         Dopamine [ATC:C01CA04]
         Dopexamine [ATC:C01CA14]
         Ibopamine [ATC:C01CA16 S01FB03]
         Methylergometrine [ATC:G02AB01]
         Ergot alkaloids [ATC:G02AB02]
         Ergometrine [ATC:G02AB03]
         Bromocriptine [ATC:G02CB01 N04BC01]
         Lisuride [ATC:G02CB02 N02CA07]
         Cabergoline [ATC:G02CB03 N04BC06]
         Quinagolide [ATC:G02CB04]
         Terguride [ATC:G02CB06]
         Apomorphine [ATC:G04BE07 N04BC07]
         Dihydroergotamine [ATC:N02CA01]
         Ergotamine [ATC:N02CA02]
         Levodopa [ATC:N04BA01]
         Pergolide [ATC:N04BC02]
         Ropinirole [ATC:N04BC04]
         Pramipexole [ATC:N04BC05]
         Piribedil [ATC:N04BC08]
         Rotigotine [ATC:N04BC09]
         Chlorpromazine [ATC:N05AA01]
         Levomepromazine [ATC:N05AA02]
         Promazine [ATC:N05AA03]
         Triflupromazine [ATC:N05AA05]
         Fluphenazine [ATC:N05AB02]
         Perphenazine [ATC:N05AB03]
         Prochlorperazine [ATC:N05AB04]
         Trifluoperazine [ATC:N05AB06]
         Thioproperazine [ATC:N05AB08]
         Periciazine [ATC:N05AC01]
         Thioridazine [ATC:N05AC02]
         Haloperidol [ATC:N05AD01]
         Trifluperidol [ATC:N05AD02]
         Moperone [ATC:N05AD04]
         Pipamperone [ATC:N05AD05]
         Bromperidol [ATC:N05AD06]
         Droperidol [ATC:N05AD08]
         Molindone [ATC:N05AE02]
         Sertindole [ATC:N05AE03]
         Ziprasidone [ATC:N05AE04]
         Flupentixol [ATC:N05AF01]
         Clopenthixol [ATC:N05AF02]
         Tiotixene [ATC:N05AF04]
         Zuclopenthixol [ATC:N05AF05]
         Pimozide [ATC:N05AG02]
         Loxapine [ATC:N05AH01]
         Clozapine [ATC:N05AH02]
         Olanzapine [ATC:N05AH03]
         Quetiapine [ATC:N05AH04]
           D08456  Quetiapine (INN)
           D00458  Quetiapine fumarate (JAN/USAN)
Antagonist
Antagonist
         Asenapine [ATC:N05AH05]
         Sulpiride [ATC:N05AL01]
         Sultopride [ATC:N05AL02]
         Tiapride [ATC:N05AL03]
         Remoxipride [ATC:N05AL04]
         Levosulpiride [ATC:N05AL07]
         Risperidone [ATC:N05AX08]
         Mosapramine [ATC:N05AX10]
         Zotepine [ATC:N05AX11]
         Aripiprazole [ATC:N05AX12]
         Paliperidone [ATC:N05AX13]
         Opipramol [ATC:N06AA05]
         Aplindore
         Bifeprunox
         Blonanserin
         Brexpiprazole
         Butaclamol
         Cariprazine
         Ciladopa
         Clocapramine
         Iloperidone
         Lergotrile
         Lurasidone
         Mazapertine
         Methoxypromazine
         Nemonapride
         Oxiperomide
         Pardoprunox
         Perospirone
         Piquindone
         Pridopidine
         Quinelorane
         Quinpirole
         Spiperone
         Sibenadet
         Talipexole
         Timiperone
         Tiospirone
         Raclopride C11
       dopamine D3-receptor [HSA:1814] [KO:K04146]
         Levodopa [ATC:N04BA01]
         Pramipexole [ATC:N04BC05]
         Dopamine [ATC:C01CA04]
         Dopexamine [ATC:C01CA14]
         Piribedil [ATC:N04BC08]
         Pimozide [ATC:N05AG02]
         Olanzapine [ATC:N05AH03]
         Quetiapine [ATC:N05AH04]
           D08456  Quetiapine (INN)
           D00458  Quetiapine fumarate (JAN/USAN)
Antagonist
Antagonist
         Sulpiride [ATC:N05AL01]
         Levosulpiride [ATC:N05AL07]
         Cariprazine
         Nemonapride
         Oxiperomide
         Pardoprunox
         Quinpirole
       dopamine D4-receptor [HSA:1815] [KO:K04147]
         Levodopa [ATC:N04BA01]
         Pramipexole [ATC:N04BC05]
         Dopamine [ATC:C01CA04]
         Dopexamine [ATC:C01CA14]
         Clozapine [ATC:N05AH02]
         Olanzapine [ATC:N05AH03]
         Quetiapine [ATC:N05AH04]
           D08456  Quetiapine (INN)
           D00458  Quetiapine fumarate (JAN/USAN)
Antagonist
Antagonist
         Fananserin
         Nemonapride
         Oxiperomide
         Sonepiprazole
       dopamine D5-receptor [HSA:1816] [KO:K05840]
     Histamine
       H1-receptor [HSA:3269] [KO:K04149]
         Ketanserin [ATC:C02KD01]
         Thonzylamine [ATC:D04AA01 R01AC06 R06AC06]
         Mepyramine [ATC:D04AA02 R06AC01]
         Tripelennamine [ATC:D04AA04]
         Promethazine [ATC:D04AA10 R06AD02]
         Dimetindene [ATC:D04AA13 R06AB03]
         Clemastine [ATC:D04AA14 R06AA04]
         Bamipine [ATC:D04AA15 R06AX01]
         Isothipendyl [ATC:D04AA22 R06AD09]
         Diphenhydramine [ATC:D04AA32 R06AA02]
         Chlorphenoxamine [ATC:D04AA34 R06AA06]
         Dimetotiazine [ATC:N02CX05]
         Chlorpromazine [ATC:N05AA01]
         Olanzapine [ATC:N05AH03]
         Quetiapine [ATC:N05AH04]
           D08456  Quetiapine (INN)
           D00458  Quetiapine fumarate (JAN/USAN)
Antagonist
Antagonist
         Hydroxyzine [ATC:N05BB01]
         Opipramol [ATC:N06AA05]
         Betahistine [ATC:N07CA01]
         Cinnarizine [ATC:N07CA02]
         Levocabastine [ATC:R01AC02 S01GX02]
         Azelastine [ATC:R01AC03 R06AX19 S01GX07]
         Antazoline [ATC:R01AC04 R06AX05]
         Olopatadine [ATC:R01AC08 S01GX09]
         Diphenylpyraline [ATC:R06AA07]
         Carbinoxamine [ATC:R06AA08]
         Doxylamine [ATC:R06AA09]
         Brompheniramine [ATC:R06AB01]
         Dexchlorpheniramine [ATC:R06AB02]
         Chlorphenamine [ATC:R06AB04]
         Pheniramine [ATC:R06AB05]
         Dexbrompheniramine [ATC:R06AB06]
         Alimemazine [ATC:R06AD01]
         Mequitazine [ATC:R06AD07]
         Cyclizine [ATC:R06AE03]
         Meclozine [ATC:R06AE05]
         Oxatomide [ATC:R06AE06]
         Cetirizine [ATC:R06AE07]
         Levocetirizine [ATC:R06AE09]
         Cyproheptadine [ATC:R06AX02]
         Phenindamine [ATC:R06AX04]
         Triprolidine [ATC:R06AX07]
         Azatadine [ATC:R06AX09]
         Astemizole [ATC:R06AX11]
         Terfenadine [ATC:R06AX12]
         Loratadine [ATC:R06AX13]
         Ketotifen [ATC:R06AX17 S01GX08]
         Acrivastine [ATC:R06AX18]
         Ebastine [ATC:R06AX22]
         Epinastine [ATC:R06AX24]
         Fexofenadine [ATC:R06AX26]
         Desloratadine [ATC:R06AX27]
         Rupatadine [ATC:R06AX28]
         Bilastine [ATC:R06AX29]
         Emedastine [ATC:S01GX06]
         Alcaftadine
         Bepotastine
         Dimenhydrinate
         Dioxopromethazine
         Histamine
         Homochlorcyclizine
         Icotidine
         Mizolastine
         Noberastine
         Rocastine
         Tecastemizole
         Temelastine
       H2-receptor [HSA:3274] [KO:K04150]
       H3-receptor [HSA:11255] [KO:K04151]
       H4-receptor [HSA:59340] [KO:K04152]
     Serotonin
       5-HT1A-receptor [HSA:3350] [KO:K04153]
       5-HT1B-receptor [HSA:3351] [KO:K04153]
       5-HT1D-receptor [HSA:3352] [KO:K04153]
       5-HT1F-receptor [HSA:3355] [KO:K04153]
       5-HT1-receptor [HSA:3350 3351 3352 3354 3355] [KO:K04153]
       5-HT2A-receptor [HSA:3356] [KO:K04157]
         Ketanserin [ATC:C02KD01]
         Naftidrofuryl [ATC:C04AX21]
         Methysergide [ATC:N02CA04]
         Pizotifen [ATC:N02CX01]
         Pipamperone [ATC:N05AD05]
         Sertindole [ATC:N05AE03]
         Clozapine [ATC:N05AH02]
         Olanzapine [ATC:N05AH03]
         Quetiapine [ATC:N05AH04]
           D08456  Quetiapine (INN)
           D00458  Quetiapine fumarate (JAN/USAN)
Antagonist
Antagonist
         Risperidone [ATC:N05AX08]
         Mosapramine [ATC:N05AX10]
         Zotepine [ATC:N05AX11]
         Aripiprazole [ATC:N05AX12]
         Paliperidone [ATC:N05AX13]
         Trazodone [ATC:N06AX05]
         Nefazodone [ATC:N06AX06]
         Altanserin
         Amesergide
         Blonanserin
         Brexpiprazole
         Eplivanserin
         Fananserin
         Iloperidone
         Lubazodone
         Nelotanserin
         Perospirone
         Pimavanserin
         Pruvanserin
         Ritanserin
         Sarpogrelate
         Spiperone
         Temanogrel
       5-HT2C-receptor [HSA:3358] [KO:K04157]
       5-HT2-receptor [HSA:3356 3357 3358] [KO:K04157]
       5-HT3-receptor [HSA:3359 9177 170572 200909 285242] [KO:K04819]
       5-HT4-receptor [HSA:3360] [KO:K04160]
       5-HT5-receptor [HSA:3361] [KO:K04161]
       5-HT6-receptor [HSA:3362] [KO:K04162]
         Metergoline [ATC:G02CB05]
         Quetiapine [ATC:N05AH04]
           D08456  Quetiapine (INN)
           D00458  Quetiapine fumarate (JAN/USAN)
Antagonist
Antagonist
         Cerlapirdine
       5-HT7-receptor [HSA:3363] [KO:K04163]
     Tachykinin / neurokinin
     Ghrelin
     Orexin
     Neuropeptide Y
     Opioid
     Angiotensin
     Bradykinin
     Endothelin
     Lutropin-choriogonadotropic hormone
     Follicle stimulating hormone
     Oxytocin
     Vasopressin
     Melanocortin
     Gonadotropin-releasing hormone
     Somatostatin
     Thyrotropin-releasing hormone
     Cholecystokinin
     Motilin
     Thrombin
     Purine / pyrimidine
     Adenosine
     Prostaglandin
     Prostacyclin
     Leukotriene
     Thromboxane
     Sphingolipid
     Free fatty acid
     Cannabinoid
     Platelet activating factor
     Melatonin
     Cysteinyl leukotriene
   Secretin receptor family
   Metabotropic glutamate receptor family
   Others
 
 Cytokine receptors
 
 Nuclear receptors
 
 Ion channels
 
 Transporters
 
 Enzymes
 
 Protein kinases
 
 Cytokines
 
 Others

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Last updated: February 28, 2014

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