Target-based Classification of Drugs

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     Remark
 G Protein-coupled receptors
   Rhodopsin family
     Acetylcholine (muscarinic)
     Adrenaline
       alpha1a-adrenergic receptor [HSA:148] [KO:K04135]
       alpha1-adrenergic receptor [HSA:148 147 146] [KO:K04135 K04136 K04137]
         Epinephrine [DG:DG00013]
         Adrenalone [DG:DG00016]
         Amiodarone [DG:DG00204]
         Quinidine [DG:DG00192]
         Etilefrine [DG:DG00210]
         Norepinephrine [DG:DG00212]
         Norfenefrine [DG:DG00214]
         Phenylephrine [DG:DG00215]
         Dobutamine [DG:DG00216]
         Oxedrine [DG:DG00217]
         Metaraminol [DG:DG00218]
         Methoxamine [DG:DG00219]
         Midodrine [DG:DG00224]
         Ephedrine [DG:DG00227]
         Prazosin [DG:DG00253]
         Indoramin [DG:DG00254]
         Trimazosin [DG:DG00255]
         Doxazosin [DG:DG00256]
         Urapidil [DG:DG00257]
         Ketanserin [DG:DG00265]
         Phentolamine [DG:DG00280]
         Tolazoline [DG:DG00281]
         Nicergoline [DG:DG00283]
         Phenoxybenzamine [DG:DG00285]
         Moxisylyte [DG:DG00287]
         Ifenprodil [DG:DG00292]
         Bevantolol [DG:DG02494]
         Labetalol [DG:DG00320]
         Carvedilol [DG:DG00321]
         Methylergometrine [DG:DG00445]
         Ergometrine [DG:DG00446]
         Alfuzosin [DG:DG00489]
         Tamsulosin [DG:DG00490]
         Terazosin [DG:DG00491]
         Dihydroergotamine [DG:DG00833]
         Ergotamine [DG:DG00834]
         Levomepromazine [DG:DG00868]
         Droperidol [DG:DG02601]
         Pimozide [DG:DG02471]
         Sertindole [DG:DG02473]
         Olanzapine [DG:DG00898]
         Quetiapine [DG:DG00899]
           D08456  Quetiapine (INN)
           D00458  Quetiapine fumarate (JP17/USAN)
Antagonist
Antagonist
         Risperidone [DG:DG02472]
         Mianserin [DG:DG00951]
         Oxymetazoline [DG:DG01029]
         Tetryzoline [DG:DG01030]
         Xylometazoline [DG:DG01031]
         Naphazoline [DG:DG01032]
         Tramazoline [DG:DG01033]
         Pseudoephedrine [DG:DG01042]
         Dipivefrine [DG:DG01129]
         Dapiprazole [DG:DG01140]
         Methylephedrine [DG:DG01229]
         Setiptiline [DG:DG01231]
         Amosulalol [DG:DG01302]
         Arotinolol [DG:DG01303]
         Bunazosin [DG:DG01316]
         Medroxalol [DG:DG01317]
         Amidephrine [DG:DG02432]
         Bunitrolol [DG:DG02464]
         Guanadrel [DG:DG02468]
         Naftopidil [DG:DG02469]
         Pelanserin [DG:DG02470]
         Nipradilol [DG:DG02533]
       alpha2b-adrenergic receptor [HSA:151] [KO:K04139]
       alpha2-adrenergic receptor [HSA:150 151 152] [KO:K04138 K04139 K04140]
         Epinephrine [DG:DG00013]
         Norepinephrine [DG:DG00212]
         Oxedrine [DG:DG00217]
         Metaraminol [DG:DG00218]
         Ephedrine [DG:DG00227]
         Methyldopa (levorotatory) [DG:DG00248]
         Clonidine [DG:DG00249]
         Guanfacine [DG:DG00250]
         Rilmenidine [DG:DG02489]
         Phentolamine [DG:DG00280]
         Tolazoline [DG:DG00281]
         Phenoxybenzamine [DG:DG00285]
         Brimonidine [DG:DG00442]
         Methylergometrine [DG:DG00445]
         Ergometrine [DG:DG00446]
         Yohimbin [DG:DG00485]
         Tizanidine [DG:DG00773]
         Piribedil [DG:DG02488]
         Chlorpromazine [DG:DG00867]
         Levomepromazine [DG:DG00868]
         Clozapine [DG:DG02476]
         Quetiapine [DG:DG00899]
           D08456  Quetiapine (INN)
           D00458  Quetiapine fumarate (JP17/USAN)
Antagonist
Antagonist
         Asenapine [DG:DG02427]
         Dexmedetomidine [DG:DG00926]
         Mianserin [DG:DG00951]
         Mirtazapine [DG:DG02487]
         Pseudoephedrine [DG:DG01042]
         Dipivefrine [DG:DG01129]
         Dapiprazole [DG:DG01140]
         Methylephedrine [DG:DG01229]
         Tramazoline [DG:DG01033]
         Apraclonidine [DG:DG01130]
         Setiptiline [DG:DG01231]
         Detomidine [DG:DG01318]
         Guanabenz [DG:DG01319]
         Medetomidine [DG:DG01320]
         Xylazine [DG:DG01321]
         Guanadrel [DG:DG02468]
         Aptazapine [DG:DG02474]
         Atipamezole [DG:DG02475]
         Delequamine [DG:DG02477]
         Fluparoxan [DG:DG02485]
         Levonordefrin [DG:DG02486]
         Romifidine [DG:DG02490]
       beta1-adrenergic receptor [HSA:153] [KO:K04141]
       beta2-adrenergic receptor [HSA:154] [KO:K04142]
       beta3-adrenergic receptor [HSA:155] [KO:K04143]
       beta-adrenergic receptor [HSA:153 154 155] [KO:K04141 K04142 K04143]
     Dopamine
       dopamine D1-receptor [HSA:1812] [KO:K04144]
         Clebopride [DG:DG00059]
         Ibopamine [DG:DG00223]
         Fenoldopam [DG:DG00226]
         Methylergometrine [DG:DG00445]
         Ergometrine [DG:DG00446]
         Apomorphine [DG:DG00486]
         Pergolide [DG:DG00861]
         Flupentixol [DG:DG00893]
         Clopenthixol [DG:DG02560]
         Tiotixene [DG:DG00895]
         Zuclopenthixol [DG:DG00896]
         Quetiapine [DG:DG00899]
           D08456  Quetiapine (INN)
           D00458  Quetiapine fumarate (JP17/USAN)
Antagonist
Antagonist
         Asenapine [DG:DG02427]
         Ecopipam [DG:DG02562]
         Adrogolide [DG:DG02563]
         Butaclamol [DG:DG02564]
         Ciladopa [DG:DG02565]
       dopamine D2-receptor [HSA:1813] [KO:K04145]
         Metoclopramide [DG:DG00055]
         Domperidone [DG:DG00057]
         Bromopride [DG:DG02598]
         Alizapride [DG:DG00058]
         Clebopride [DG:DG00059]
         Ibopamine [DG:DG00223]
         Bromocriptine [DG:DG00452]
         Lisuride [DG:DG00453]
         Cabergoline [DG:DG02465]
         Quinagolide [DG:DG00454]
         Apomorphine [DG:DG00486]
         Dihydroergotamine [DG:DG00833]
         Ergotamine [DG:DG00834]
         Pergolide [DG:DG00861]
         Ropinirole [DG:DG00862]
         Pramipexole [DG:DG00863]
         Piribedil [DG:DG02488]
         Rotigotine [DG:DG02549]
         Chlorpromazine [DG:DG00867]
         Levomepromazine [DG:DG00868]
         Triflupromazine [DG:DG00871]
         Fluphenazine [DG:DG00874]
         Perphenazine [DG:DG00875]
         Prochlorperazine [DG:DG00876]
         Trifluoperazine [DG:DG00877]
         Thioproperazine [DG:DG00879]
         Thioridazine [DG:DG00882]
         Haloperidol [DG:DG00885]
         Trifluperidol [DG:DG00886]
         Moperone [DG:DG00888]
         Pipamperone [DG:DG00889]
         Bromperidol [DG:DG00890]
         Droperidol [DG:DG02601]
         Molindone [DG:DG00891]
         Sertindole [DG:DG02473]
         Ziprasidone [DG:DG00892]
         Flupentixol [DG:DG00893]
         Clopenthixol [DG:DG02560]
         Tiotixene [DG:DG00895]
         Zuclopenthixol [DG:DG00896]
         Pimozide [DG:DG02471]
         Loxapine [DG:DG00897]
         Clozapine [DG:DG02476]
         Olanzapine [DG:DG00898]
         Quetiapine [DG:DG00899]
           D08456  Quetiapine (INN)
           D00458  Quetiapine fumarate (JP17/USAN)
Antagonist
Antagonist
         Asenapine [DG:DG02427]
         Sulpiride [DG:DG02592]
         Levosulpiride [DG:DG02591]
         Sultopride [DG:DG00900]
         Tiapride [DG:DG00901]
         Remoxipride [DG:DG00902]
         Risperidone [DG:DG02472]
         Mosapramine [DG:DG00905]
         Aripiprazole [DG:DG00906]
         Paliperidone [DG:DG00907]
         Iloperidone [DG:DG02603]
         Brexpiprazole [DG:DG02597]
         Opipramol [DG:DG00930]
         Bifeprunox [DG:DG01304]
         Cariprazine [DG:DG01305]
         Clocapramine [DG:DG01313]
         Lergotrile [DG:DG01319]
         Pardoprunox [DG:DG01324]
         Pridopidine [DG:DG01325]
         Talipexole [DG:DG01326]
         Tiospirone [DG:DG02354]
         Sibenadet [DG:DG02546]
         Butaclamol [DG:DG02564]
         Ciladopa [DG:DG02565]
         Nemonapride [DG:DG02593]
         Quinpirole [DG:DG02594]
         Aplindore [DG:DG02595]
         Blonanserin [DG:DG02596]
         Carvotroline [DG:DG02599]
         Gevotroline [DG:DG02602]
         Lurasidone [DG:DG02604]
         Mazapertine [DG:DG02606]
         Methoxypromazine [DG:DG02607]
         Metopimazine
         Perospirone
         Periciazine
         Piquindone
         Promazine
         Quinelorane
         Raclopride C11
         Spiperone
         Terguride
         Timiperone
         Zotepine
       dopamine D3-receptor [HSA:1814] [KO:K04146]
       dopamine D4-receptor [HSA:1815] [KO:K04147]
       dopamine D5-receptor [HSA:1816] [KO:K05840]
       dopamine receptor [HSA:1812 1813 1814 1815 1816] [KO:K04144 K04145 K04146 K04147 K05840]
     Histamine
       H1-receptor [HSA:3269] [KO:K04149]
         Ketanserin [DG:DG00265]
         Thonzylamine [DG:DG00381]
         Mepyramine [DG:DG00382]
         Tripelennamine [DG:DG00383]
         Promethazine [DG:DG00385]
         Dimetindene [DG:DG00386]
         Clemastine [DG:DG00387]
         Bamipine [DG:DG00388]
         Isothipendyl [DG:DG00389]
         Diphenhydramine [DG:DG00390]
         Chlorphenoxamine [DG:DG00391]
         Dimetotiazine [DG:DG00843]
         Chlorpromazine [DG:DG00867]
         Olanzapine [DG:DG00898]
         Quetiapine [DG:DG00899]
           D08456  Quetiapine (INN)
           D00458  Quetiapine fumarate (JP17/USAN)
Antagonist
Antagonist
         Asenapine [DG:DG02427]
         Hydroxyzine [DG:DG00912]
         Opipramol [DG:DG00930]
         Betahistine [DG:DG01004]
         Cinnarizine [DG:DG01005]
         Levocabastine [DG:DG01035]
         Azelastine [DG:DG01036]
         Antazoline [DG:DG01037]
         Olopatadine [DG:DG01039]
         Diphenylpyraline [DG:DG01094]
         Carbinoxamine [DG:DG01095]
         Doxylamine [DG:DG01096]
         Brompheniramine [DG:DG01097]
         Dexchlorpheniramine [DG:DG01098]
         Chlorphenamine [DG:DG01099]
         Pheniramine [DG:DG01100]
         Alimemazine [DG:DG01101]
         Cyclizine [DG:DG01105]
         Meclozine [DG:DG01106]
         Cetirizine [DG:DG01107]
         Levocetirizine [DG:DG01108]
         Cyproheptadine [DG:DG01109]
         Phenindamine [DG:DG01110]
         Triprolidine [DG:DG01111]
         Azatadine [DG:DG01112]
         Ketotifen [DG:DG01115]
         Epinastine [DG:DG01116]
         Fexofenadine [DG:DG01117]
         Rupatadine [DG:DG01118]
         Emedastine [DG:DG01144]
         Bepotastine [DG:DG01327]
         Homochlorcyclizine [DG:DG01328]
         Acrivastine
         Alcaftadine
         Astemizole
         Bilastine
         Desloratadine
         Dexbrompheniramine
         Dimenhydrinate
         Dioxopromethazine
         Ebastine
         Histamine
         Icotidine
         Mequitazine
         Mizolastine
         Noberastine
         Loratadine
         Oxatomide
         Rocastine
         Tecastemizole
         Temelastine
         Terfenadine
       H2-receptor [HSA:3274] [KO:K04150]
       H3-receptor [HSA:11255] [KO:K04151]
       H4-receptor [HSA:59340] [KO:K04152]
     Serotonin
       5-HT1A-receptor [HSA:3350] [KO:K04153]
       5-HT1B-receptor [HSA:3351] [KO:K04153]
       5-HT1D-receptor [HSA:3352] [KO:K04153]
       5-HT1E-receptor [HSA:3354] [KO:K04153]
       5-HT1F-receptor [HSA:3355] [KO:K04153]
       5-HT1-receptor [HSA:3350 3351 3352 3354 3355] [KO:K04153]
       5-HT2A-receptor [HSA:3356] [KO:K04157]
         Ketanserin [DG:DG00265]
         Naftidrofuryl [DG:DG00290]
         Methysergide [DG:DG00835]
         Pizotifen [DG:DG00842]
         Pipamperone [DG:DG00889]
         Sertindole [DG:DG02473]
         Pimozide [DG:DG02471]
         Clozapine [DG:DG02476]
         Lurasidone [DG:DG02604]
         Olanzapine [DG:DG00898]
         Quetiapine [DG:DG00899]
           D08456  Quetiapine (INN)
           D00458  Quetiapine fumarate (JP17/USAN)
Antagonist
Antagonist
         Asenapine [DG:DG02427]
         Risperidone [DG:DG02472]
         Mosapramine [DG:DG00905]
         Aripiprazole [DG:DG00906]
         Brexpiprazole [DG:DG02597]
         Paliperidone [DG:DG00907]
         Trazodone [DG:DG00952]
         Nefazodone [DG:DG00953]
         Pruvanserin [DG:DG01278]
         Xanomeline [DG:DG01300]
         Sarpogrelate [DG:DG01333]
         Temanogrel [DG:DG01334]
         Blonanserin [DG:DG02596]
         Altanserin
         Amesergide
         Eplivanserin
         Fananserin
         Lubazodone
         Nelotanserin
         Perospirone
         Pimavanserin
         Ritanserin
         Spiperone
         Zotepine
       5-HT2B-receptor [HSA:3357] [KO:K04157]
       5-HT2C-receptor [HSA:3358] [KO:K04157]
       5-HT2-receptor [HSA:3356 3357 3358] [KO:K04157]
       5-HT3-receptor [HSA:3359 9177 170572 200909 285242] [KO:K04819]
       5-HT4-receptor [HSA:3360] [KO:K04160]
       5-HT5-receptor [HSA:3361] [KO:K04161]
       5-HT6-receptor [HSA:3362] [KO:K04162]
       5-HT7-receptor [HSA:3363] [KO:K04163]
     Tachykinin / neurokinin
     Ghrelin
     Orexin
     Neuropeptide Y
     Opioid
     Angiotensin
     Bradykinin
     Endothelin
     Lutropin-choriogonadotropic hormone
     Follicle stimulating hormone
     Oxytocin
     Vasopressin
     Melanocortin
     Gonadotropin-releasing hormone
     Somatostatin
     Thyrotropin-releasing hormone
     Cholecystokinin
     Motilin
     Thrombin
     Purine / pyrimidine
     Adenosine
     Prostaglandin
     Prostacyclin
     Leukotriene
     Thromboxane
     Sphingolipid
     Free fatty acid
     Cannabinoid
     Platelet activating factor
     Melatonin
     Cysteinyl leukotriene
   Secretin receptor family
   Metabotropic glutamate receptor family
   Others
 
 Cytokine receptors
 
 Nuclear receptors
 
 Ion channels
 
 Transporters
 
 Enzymes
 
 Protein kinases
 
 Cytokines
 
 Others

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Last updated: November 13, 2017

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