Target-based Classification of Drugs

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     Remark
 G Protein-coupled receptors
 
 Cytokine receptors
 
 Nuclear receptors
 
 Ion channels
   Cys-loop superfamily
   Glutamate-gated cation channels
   Epithelial and related channels
   Ryanodine and IP3 receptors
   Voltage-gated cation channels
     Na+ channel, SCN alpha, NaV1.x
       voltage-gated sodium channel (SCN1A) [HSA:6323] [KO:K04833]
         Quinidine [DG:DG00192]
         Procainamide [DG:DG00193]
         Disopyramide [DG:DG00194]
         Ajmaline
         Lidocaine [DG:DG00196]
         Mexiletine [DG:DG00197]
         Tocainide [DG:DG00198]
         Aprindine [DG:DG00199]
         Propafenone [DG:DG00200]
         Flecainide [DG:DG00201]
         Encainide [DG:DG00203]
         Moracizine [DG:DG00208]
         Cibenzoline [DG:DG00209]
         Tetracaine [DG:DG00296]
         Benzocaine
         Cinchocaine
         Procaine [DG:DG00298]
         Aminobenzoic acid
         Chloroprocaine
         Bupivacaine
         Mepivacaine
         Ropivacaine [DG:DG00806]
         Levobupivacaine
         Phenytoin [DG:DG00846]
         Mephenytoin
         Fosphenytoin [DG:DG00847]
         Carbamazepine
         Oxcarbazepine
         Eslicarbazepine [DG:DG00848]
         Lamotrigine
         Topiramate
         Zonisamide
         Cocaine [DG:DG00808]
         Dyclonine
           D00735  Dyclonine hydrochloride (USP)
           D07881  Dyclonine (INN)
Blocker
Blocker
         Ambroxol [DG:DG01073]
         Proparacaine
         Dibucaine
         Hydroquinidine
         Pilsicainide
         Pirmenol
       voltage-gated sodium channel (SCN2A) [HSA:6326] [KO:K04834]
         Quinidine [DG:DG00192]
         Procainamide [DG:DG00193]
         Disopyramide [DG:DG00194]
         Ajmaline
         Lidocaine [DG:DG00196]
         Mexiletine [DG:DG00197]
         Tocainide [DG:DG00198]
         Aprindine [DG:DG00199]
         Propafenone [DG:DG00200]
         Flecainide [DG:DG00201]
         Encainide [DG:DG00203]
         Moracizine [DG:DG00208]
         Cibenzoline [DG:DG00209]
         Tetracaine [DG:DG00296]
         Benzocaine
         Cinchocaine
         Procaine [DG:DG00298]
         Aminobenzoic acid
         Chloroprocaine
         Bupivacaine
         Mepivacaine
         Ropivacaine [DG:DG00806]
         Levobupivacaine
         Phenytoin [DG:DG00846]
         Mephenytoin
         Fosphenytoin [DG:DG00847]
         Carbamazepine
         Oxcarbazepine
         Eslicarbazepine [DG:DG00848]
         Lamotrigine
         Topiramate
         Zonisamide
         Cocaine [DG:DG00808]
         Dyclonine
           D00735  Dyclonine hydrochloride (USP)
           D07881  Dyclonine (INN)
Blocker
Blocker
         Ambroxol [DG:DG01073]
         Proparacaine
         Dibucaine
         Hydroquinidine
         Pilsicainide
         Pirmenol
       voltage-gated sodium channel (SCN3A) [HSA:6328] [KO:K04836]
         Quinidine [DG:DG00192]
         Procainamide [DG:DG00193]
         Disopyramide [DG:DG00194]
         Ajmaline
         Lidocaine [DG:DG00196]
         Mexiletine [DG:DG00197]
         Tocainide [DG:DG00198]
         Aprindine [DG:DG00199]
         Propafenone [DG:DG00200]
         Flecainide [DG:DG00201]
         Encainide [DG:DG00203]
         Moracizine [DG:DG00208]
         Cibenzoline [DG:DG00209]
         Tetracaine [DG:DG00296]
         Benzocaine
         Cinchocaine
         Procaine [DG:DG00298]
         Aminobenzoic acid
         Chloroprocaine
         Bupivacaine
         Mepivacaine
         Ropivacaine [DG:DG00806]
         Levobupivacaine
         Phenytoin [DG:DG00846]
         Mephenytoin
         Fosphenytoin [DG:DG00847]
         Carbamazepine
         Oxcarbazepine
         Eslicarbazepine [DG:DG00848]
         Lamotrigine
         Topiramate
         Zonisamide
         Cocaine [DG:DG00808]
         Dyclonine
           D00735  Dyclonine hydrochloride (USP)
           D07881  Dyclonine (INN)
Blocker
Blocker
         Ambroxol [DG:DG01073]
         Proparacaine
         Dibucaine
         Hydroquinidine
         Pilsicainide
         Pirmenol
       voltage-gated sodium channel (SCN4A) [HSA:6329] [KO:K04837]
         Quinidine [DG:DG00192]
         Procainamide [DG:DG00193]
         Disopyramide [DG:DG00194]
         Ajmaline
         Lidocaine [DG:DG00196]
         Mexiletine [DG:DG00197]
         Tocainide [DG:DG00198]
         Aprindine [DG:DG00199]
         Propafenone [DG:DG00200]
         Flecainide [DG:DG00201]
         Encainide [DG:DG00203]
         Moracizine [DG:DG00208]
         Cibenzoline [DG:DG00209]
         Tetracaine [DG:DG00296]
         Benzocaine
         Cinchocaine
         Procaine [DG:DG00298]
         Aminobenzoic acid
         Chloroprocaine
         Bupivacaine
         Mepivacaine
         Ropivacaine [DG:DG00806]
         Levobupivacaine
         Phenytoin [DG:DG00846]
         Mephenytoin
         Fosphenytoin [DG:DG00847]
         Carbamazepine
         Oxcarbazepine
         Eslicarbazepine [DG:DG00848]
         Lamotrigine
         Topiramate
         Zonisamide
         Cocaine [DG:DG00808]
         Dyclonine
           D00735  Dyclonine hydrochloride (USP)
Blocker
         Ambroxol [DG:DG01073]
         Proparacaine
         Dibucaine
         Hydroquinidine
         Pilsicainide
         Pirmenol
       voltage-gated sodium channel (SCN5A) [HSA:6331] [KO:K04838]
         Quinidine [DG:DG00192]
         Procainamide [DG:DG00193]
         Disopyramide [DG:DG00194]
         Ajmaline
         Lidocaine [DG:DG00196]
         Mexiletine [DG:DG00197]
         Tocainide [DG:DG00198]
         Aprindine [DG:DG00199]
         Propafenone [DG:DG00200]
         Flecainide [DG:DG00201]
         Encainide [DG:DG00203]
         Moracizine [DG:DG00208]
         Cibenzoline [DG:DG00209]
         Tetracaine [DG:DG00296]
         Benzocaine
         Cinchocaine
         Procaine [DG:DG00298]
         Aminobenzoic acid
         Chloroprocaine
         Bupivacaine
         Mepivacaine
         Ropivacaine [DG:DG00806]
         Levobupivacaine
         Phenytoin [DG:DG00846]
         Mephenytoin
         Fosphenytoin [DG:DG00847]
         Carbamazepine
         Oxcarbazepine
         Eslicarbazepine [DG:DG00848]
         Lamotrigine
         Topiramate
         Zonisamide
         Cocaine [DG:DG00808]
         Dyclonine
           D00735  Dyclonine hydrochloride (USP)
           D07881  Dyclonine (INN)
Blocker
Blocker
         Ambroxol [DG:DG01073]
         Proparacaine
         Dibucaine
         Hydroquinidine
         Pilsicainide
         Pirmenol
       voltage-gated sodium channel (SCN8A) [HSA:6334] [KO:K04840]
         Quinidine [DG:DG00192]
         Procainamide [DG:DG00193]
         Disopyramide [DG:DG00194]
         Ajmaline
         Lidocaine [DG:DG00196]
         Mexiletine [DG:DG00197]
         Tocainide [DG:DG00198]
         Aprindine [DG:DG00199]
         Propafenone [DG:DG00200]
         Flecainide [DG:DG00201]
         Encainide [DG:DG00203]
         Moracizine [DG:DG00208]
         Cibenzoline [DG:DG00209]
         Tetracaine [DG:DG00296]
         Benzocaine
         Cinchocaine
         Procaine [DG:DG00298]
         Aminobenzoic acid
         Chloroprocaine
         Bupivacaine
         Mepivacaine
         Ropivacaine [DG:DG00806]
         Levobupivacaine
         Phenytoin [DG:DG00846]
         Mephenytoin
         Fosphenytoin [DG:DG00847]
         Carbamazepine
         Oxcarbazepine
         Eslicarbazepine [DG:DG00848]
         Lamotrigine
         Topiramate
         Zonisamide
         Cocaine [DG:DG00808]
         Dyclonine
           D00735  Dyclonine hydrochloride (USP)
           D07881  Dyclonine (INN)
Blocker
Blocker
         Ambroxol [DG:DG01073]
         Proparacaine
         Dibucaine
         Hydroquinidine
         Pilsicainide
         Pirmenol
       voltage-gated sodium channel (SCN9A) [HSA:6335] [KO:K04841]
         Quinidine [DG:DG00192]
         Procainamide [DG:DG00193]
         Disopyramide [DG:DG00194]
         Ajmaline
         Lidocaine [DG:DG00196]
         Mexiletine [DG:DG00197]
         Tocainide [DG:DG00198]
         Aprindine [DG:DG00199]
         Propafenone [DG:DG00200]
         Flecainide [DG:DG00201]
         Encainide [DG:DG00203]
         Moracizine [DG:DG00208]
         Cibenzoline [DG:DG00209]
         Tetracaine [DG:DG00296]
         Benzocaine
         Cinchocaine
         Procaine [DG:DG00298]
         Aminobenzoic acid
         Chloroprocaine
         Bupivacaine
         Mepivacaine
         Ropivacaine [DG:DG00806]
         Levobupivacaine
         Phenytoin [DG:DG00846]
         Mephenytoin
         Fosphenytoin [DG:DG00847]
         Carbamazepine
         Oxcarbazepine
         Eslicarbazepine [DG:DG00848]
         Lamotrigine
         Topiramate
         Zonisamide
         Cocaine [DG:DG00808]
         Dyclonine
           D00735  Dyclonine hydrochloride (USP)
           D07881  Dyclonine (INN)
Blocker
Blocker
         Ambroxol [DG:DG01073]
         Proparacaine
         Dibucaine
         Hydroquinidine
         Pilsicainide
         Pirmenol
       voltage-gated sodium channel (SCN10A) [HSA:6336] [KO:K04842]
         Lidocaine [DG:DG00196]
         Tetracaine [DG:DG00296]
         Benzocaine
         Cinchocaine
         Procaine [DG:DG00298]
         Aminobenzoic acid
         Chloroprocaine
         Bupivacaine
         Mepivacaine
         Ropivacaine [DG:DG00806]
         Levobupivacaine
         Cocaine [DG:DG00808]
         Dyclonine
           D00735  Dyclonine hydrochloride (USP)
           D07881  Dyclonine (INN)
Blocker
Blocker
         Proparacaine
         Dibucaine
       voltage-gated sodium channel
       sodium channel
     Ca2+ channel, CACN alpha-1, CaVx.x
     K+ channel, KCNA, Kv1.x (Shaker)
     K+ channel, KCNC, Kv3.x (Shaw)
     K+ channel, KCND, Kv4.x (Shal)
     K+ channel, KCNQ, Kv7.x (KQT-like)
     K+ channel, KCNH, Kv10-12.x (Ether-a-go-go)
     K+ channel, KCNK, K2px.x
   Related to voltage-gated cation channels
   Chloride channels
 
 Transporters
 
 Enzymes
 
 Protein kinases
 
 Cytokines
 
 Others

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Last updated: July 22, 2014

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