Target-based Classification of Drugs

[ Brite menu | Download htext ]
    

1st Level  2nd Level  3rd Level  4th Level  5th Level  6th Level 

     Remark
 G Protein-coupled receptors
 
 Cytokine receptors
 
 Nuclear receptors
 
 Ion channels
 
 Transporters
 
 Enzymes
   Oxidoreductases
     alcohol dehydrogenase [HSA:124 125 126 127 128 130 131] [KO:K13951 K13980 K00121 K13952]
     aldose reductase [HSA:231] [KO:K00011]
     hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase [HSA:3156] [KO:K00021]
     3beta-hydroxysteroid dehydrogenase type 1 [HSA:3283] [KO:K00070]
     hydroxysteroid (11-beta) dehydrogenase 1 [HSA:3290] [KO:K00071]
     IMP dehydrogenase [HSA:3614 3615] [KO:K00088]
     vitamin-K-epoxide reductase [HSA:79001] [KO:K05357]
     aldehyde dehydrogenase [HSA:217 219 224] [KO:K00128]
     dihydropyrimidine dehydrogenase [HSA:1806] [KO:K00207]
     dihydroorotate dehydrogenase (DHODH) [HSA:1723] [KO:K00254]
     5alpha-reductase 1 [HSA:6715] [KO:K12343]
     5alpha-reductase 2 [HSA:6716] [KO:K12344]
     5alpha-reductase 3 [HSA:79644] [KO:K12345]
     monoamine oxidase (MAO) [HSA:4128 4129] [KO:K00274]
       Amezinium metilsulfate
       Pargyline [DG:DG00264]
       Isoniazid [DG:DG00642]
       Isocarboxazid
       Nialamide
       Phenelzine [DG:DG00948]
       Tranylcypromine [DG:DG00949]
       Iproniazide [DG:DG00950]
       Iproclozide
       Caroxazone
       Etryptamine
       Ladostigil
         D03239  Ladostigil tartrate (USAN)
Inhibitor
       Safrazine
     monoamine oxidase A (MAO-A) [HSA:4128] [KO:K00274]
     monoamine oxidase B (MAO-B) [HSA:4129] [KO:K00274]
     dihydrofolate reductase [HSA:1719 200895] [KO:K00287]
     phylloquinone reductase [HSA:1728] [KO:K00355]
     thyroid peroxidase [HSA:7173] [KO:K00431]
     4-hydroxyphenylpyruvate dioxygenase [HSA:3242] [KO:K00457]
     arachidonate 5-lipoxygenase [HSA:240] [KO:K00461]
     prolyl 4-hydroxylase [HSA:5033 8974 283208] [KO:K00472]
     inducible nitric oxide synthase (iNOS) [HSA:4843] [KO:K13241]
     nitric oxide synthase (NOS) [HSA:4842 4843 4846] [KO:K13240 K13241 K13242]
     CYP3A [HSA:1551 1576 1577 64816] [KO:K07424]
     aromatase [HSA:1588] [KO:K07434]
     steroid 11beta-monooxygenase (CYP11B1) [HSA:1584] [KO:K00497]
     tyrosine 3-monooxygenase [HSA:7054] [KO:K00501]
     dopamine beta-hydroxylase [HSA:1621] [KO:K00503]
     tyrosinase [HSA:7299] [KO:K00505]
     cyclooxygenase-1 (COX-1) [HSA:5742] [KO:K00509]
     cyclooxygenase-2 (COX-2) [HSA:5743] [KO:K11987]
     CYP17 [HSA:1586] [KO:K00512]
     xanthine dehydrogenase/oxidase [HSA:7498] [KO:K00106]
     ribonucleotide reductase inhibitor [HSA:50484 6240 6241] [KO:K10807 K10808]
     ribonucleotide reductase M1 [HSA:6240] [KO:K10807]
     ribonucleotide reductase M2 [HSA:6241] [KO:K10808]
     type I iodothyronine deiodinase [HSA:1733] [KO:K01562]
     type II iodothyronine deiodinase [HSA:1734] [KO:K01562]
   Transferases
   Hydrolases
     pancreatic lipase [HSA:5406 5407 5408] [KO:K14073 K14074 K14075]
     bile salt-stimulated lipase inhibitor [HSA:1056] [KO:K12298]
     secretory phospholipase A2 (PLA2) [HSA:26279 30814 391013 50487 5319 5320 5322 64600 81579 8399 84647] [KO:K01047]
     cytosolic phospholipase A2-alpha (cPLA2-alpha) [HSA:5321] [KO:K16342]
     acetylcholinesterase (AChE) [HSA:43] [KO:K01049]
       Dimetacrine
       Tacrine [DG:DG00982]
       Donepezil [DG:DG00983]
       Rivastigmine [DG:DG00984]
       Galantamine [DG:DG00985]
       Neostigmine [DG:DG00987]
       Pyridostigmine
       Ambenonium
       Ecothiopate
       Demecarium
       Physostigmine [DG:DG01132]
       Fluostigmine
       Pralidoxime
       Obidoxime
       Acotiamide
       Besipirdine
       Caracemide
       Edrophonium
       Icopezil
       Ipidacrine
       Itopride
       Ladostigil
         D03239  Ladostigil tartrate (USAN)
Inhibitor
       Latrepirdine
       Velnacrine
     butyrylcholinesterase (BChE) [HSA:590] [KO:K01050]
     lipoprotein lipase [HSA:4023] [KO:K01059]
     lipoprotein-associated phospholipase A2 (LP-PLA2) [HSA:7941]
     calcineurin [HSA:5530 5532 5533 5534 5535 11261 63928] [KO:K04348 K06268]
     protein tyrosine phosphatase, non-receptor type 1 (PTP1B) [HSA:5777] [KO:K05697]
     phosphodiesterase (PDE) [HSA:10846 27115 50940 5136 5137 5138 5139 5140 5141 5142 5143 5144 5150 5151 5153 8622] [KO:K01120 K13296 K13298 K13755]
     phosphodiesterase (PDE) III [HSA:5139 5140] [KO:K13296]
     phosphodiesterase (PDE) IV [HSA:5141 5142 5143 5144] [KO:K01120]
     phosphodiesterase (PDE) V [HSA:8654] [KO:K13762]
     steroid sulfatase [HSA:412] [KO:K01131]
     alpha-amylase [HSA:279 280] [KO:K01176]
     alpha-glucosidase [HSA:2548 2595 8972] [KO:K12316 K12317 K12047]
     aminopeptidase N [HSA:290] [KO:K11140]
     aminopeptidase B [HSA:6051] [KO:K01260]
     renal dehydropeptidase I [HSA:1800] [KO:K01273]
     dipeptidyl-peptidase 4 (DPP4) [HSA:1803] [KO:K01278]
     angiotensin-converting enzyme (ACE) [HSA:1636] [KO:K01283]
     alpha-chymotrypsin [HSA:1504 440387] [KO:K01310]
     trypsin [HSA:5644 5645 5646] [KO:K01312]
     thrombin [HSA:2147] [KO:K01313]
     factor Xa [HSA:2159] [KO:K01314]
     plasmin [HSA:5340] [KO:K01315]
     coagulation factor IX [HSA:2158] [KO:K01321]
     coagulation factor VIII [HSA:2157] [KO:K03899]
     plasma kallikrein [HSA:3818] [KO:K01324]
     tissue kallikrein [HSA:3816 3817] [KO:K01325]
     leukocyte elastase [HSA:1991] [KO:K01327]
     protein C [HSA:5624] [KO:K01344]
     proprotein convertase subtilisin/kexin type 9 (PCSK9) [HSA:255738] [KO:K13050]
     caspase 1 (CASP1) [HSA:834] [KO:K01370]
     cathepsin K [HSA:1513] [KO:K01371]
     renin [HSA:5972] [KO:K01380]
     neutral endopeptidase [HSA:4311] [KO:K01389]
     matrix metalloproteinase 1 [HSA:4312] [KO:K01388]
     matrix metalloproteinase 2 [HSA:4313] [KO:K01398]
     matrix metalloproteinase 3 [HSA:4314] [KO:K01394]
     matrix metalloproteinase 8 [HSA:101] [KO:K06540]
     matrix metalloproteinase 9 [HSA:4318] [KO:K01403]
     matrix metalloproteinase 13 [HSA:4322] [KO:K07994]
     matrix metalloproteinase 14 [HSA:4323] [KO:K07763]
     matrix metalloproteinase
     ADAM10 (CD156c) [HSA:102] [KO:K06704]
     ADAM17 (CD156B) [HSA:6868] [KO:K06059]
     proteasome subunit beta type-1 (PSMB1) [HSA:5689] [KO:K02732]
     proteasome subunit beta type-2 (PSMB2) [HSA:5690] [KO:K02734]
     proteasome subunit beta type-5 (PSMB5) [HSA:5693] [KO:K02737]
     urease [KO:K01428 K01429 K01430 K14048]
     histone deacetylase [HSA:3065 3066 8841 9759 10014 10013 51564 55869 9734 83933] [KO:K06067 K11404 K11405 K11406 K11407 K11408 K11409]
     histone deacetylase 1 (HDAC1) [HSA:3065] [KO:K06067]
     histone deacetylase 2 (HDAC2) [HSA:3066] [KO:K06067]
     histone deacetylase 3 (HDAC3) [HSA:8841] [KO:K11404]
     histone deacetylase 6 (HDAC6) [HSA:10013] [KO:K11407]
     adenosine deaminase [HSA:100] [KO:K01488]
     sodium/potassium-transporting ATPase [HSA:476 477 478 480 23439 481 482 483] [KO:K01539 K01540]
     H+/K+ exchanging, polypeptide [HSA:495 496] [KO:K01542 K01543]
     P-glycoprotein [HSA:5243] [KO:K05658]
     prostate-specific membrane antigen (PSMA) [HSA:2346] [KO:K14592]
   Lyases
   Isomerases
 
 Protein kinases
 
 Cytokines
 
 Others

[ DRUG | BRITE | KEGG2 | KEGG ]
Last updated: July 22, 2014

» Japanese version