Target-based Classification of Drugs

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     Remark
 G Protein-coupled receptors
   Rhodopsin family
     Acetylcholine (muscarinic)
     Adrenaline
       alpha1a-adrenergic receptor [HSA:148] [KO:K04135]
       alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
         Epinephrine [DG:DG00013]
         Adrenalone [DG:DG00016]
         Etilefrine [DG:DG00210]
         Norepinephrine [DG:DG00212]
         Norfenefrine [DG:DG00214]
         Phenylephrine [DG:DG00215]
         Oxedrine [DG:DG00217]
         Metaraminol [DG:DG00218]
         Methoxamine [DG:DG00219]
         Midodrine [DG:DG00224]
         Ephedrine [DG:DG00227]
         Prazosin [DG:DG00253]
         Indoramin [DG:DG00254]
         Trimazosin [DG:DG00255]
         Doxazosin [DG:DG00256]
         Urapidil [DG:DG00257]
         Ketanserin [DG:DG00265]
         Phentolamine [DG:DG00280]
         Tolazoline [DG:DG00281]
         Nicergoline [DG:DG00283]
         Phenoxybenzamine [DG:DG00285]
         Moxisylyte [DG:DG00287]
         Ifenprodil [DG:DG00292]
         Labetalol [DG:DG00320]
         Carvedilol [DG:DG00321]
         Methylergometrine [DG:DG00445]
         Ergometrine [DG:DG00446]
           D07905  Ergometrine (INN)
           D01163  Ergonovine maleate (USP)
Agonist/Antagonist
Agonist/Antagonist
         Alfuzosin [DG:DG00489]
         Tamsulosin [DG:DG00490]
         Terazosin [DG:DG00491]
         Dihydroergotamine [DG:DG00833]
         Ergotamine [DG:DG00834]
         Levomepromazine [DG:DG00868]
         Olanzapine [DG:DG00898]
         Quetiapine [DG:DG00899]
         Mianserin [DG:DG00951]
         Oxymetazoline [DG:DG01029]
         Tetryzoline [DG:DG01030]
         Xylometazoline [DG:DG01031]
         Naphazoline [DG:DG01032]
         Tramazoline [DG:DG01033]
         Pseudoephedrine [DG:DG01042]
         Dipivefrine [DG:DG01129]
         Methylephedrine [DG:DG01229]
         Setiptiline [DG:DG01231]
         Amosulalol [DG:DG01302]
         Arotinolol [DG:DG01303]
         Bunazosin [DG:DG01316]
         Medroxalol [DG:DG01317]
         Amidephrine
         Arbutamine
         Asenapine
         Bunitrolol
         Clozapine
         Dapiprazole
         Ergot alkaloids
         Guanadrel
         Naftopidil
         Pelanserin
         Pimozide
         Risperidone
         Sertindole
         Silodosin
       alpha2b-adrenergic receptor [HSA:151] [KO:K04139]
       alpha2-adrenergic receptor [HSA:150 151 152] [KO:K04138 K04139 K04140]
         Epinephrine [DG:DG00013]
         Norepinephrine [DG:DG00212]
         Oxedrine [DG:DG00217]
         Metaraminol [DG:DG00218]
         Ephedrine [DG:DG00227]
         Methyldopa (levorotatory) [DG:DG00248]
         Clonidine [DG:DG00249]
         Guanfacine [DG:DG00250]
         Phentolamine [DG:DG00280]
         Tolazoline [DG:DG00281]
         Phenoxybenzamine [DG:DG00285]
         Methylergometrine [DG:DG00445]
         Ergometrine [DG:DG00446]
           D07905  Ergometrine (INN)
           D01163  Ergonovine maleate (USP)
Agonist/Antagonist
Agonist/Antagonist
         Yohimbin [DG:DG00485]
         Tizanidine [DG:DG00773]
         Chlorpromazine [DG:DG00867]
         Levomepromazine [DG:DG00868]
         Dexmedetomidine [DG:DG00926]
         Mianserin [DG:DG00951]
         Pseudoephedrine [DG:DG01042]
         Dipivefrine [DG:DG01129]
         Methylephedrine [DG:DG01229]
         Apraclonidine [DG:DG01130]
         Setiptiline [DG:DG01231]
         Detomidine [DG:DG01318]
         Guanabenz [DG:DG01319]
         Medetomidine [DG:DG01320]
         Xylazine; Veterinary [DG:DG01321]
         Rilmenidine
         Ergot alkaloids
         Piribedil
         Asenapine
         Mirtazapine
         Brimonidine
         Dapiprazole
         Aptazapine
         Atipamezole
         Delequamine
         Fluparoxan
         Guanadrel
         Levonordefrin
         Romifidine
       beta1-adrenergic receptor [HSA:153] [KO:K04141]
       beta2-adrenergic receptor [HSA:154] [KO:K04142]
       beta3-adrenergic receptor [HSA:155] [KO:K04143]
     Dopamine
       dopamine D1-receptor [HSA:1812] [KO:K04144]
       dopamine D2-receptor [HSA:1813] [KO:K04145]
         Metoclopramide [DG:DG00055]
         Domperidone [DG:DG00057]
         Alizapride [DG:DG00058]
         Clebopride [DG:DG00059]
         Dopamine [DG:DG00213]
         Ibopamine [DG:DG00223]
         Methylergometrine [DG:DG00445]
         Ergometrine [DG:DG00446]
           D07905  Ergometrine (INN)
           D01163  Ergonovine maleate (USP)
Agonist/Antagonist
Agonist/Antagonist
         Bromocriptine [DG:DG00452]
         Lisuride [DG:DG00453]
         Quinagolide [DG:DG00454]
         Apomorphine [DG:DG00486]
         Dihydroergotamine [DG:DG00833]
         Ergotamine [DG:DG00834]
         Pergolide [DG:DG00861]
         Ropinirole [DG:DG00862]
         Pramipexole [DG:DG00863]
         Chlorpromazine [DG:DG00867]
         Levomepromazine [DG:DG00868]
         Triflupromazine [DG:DG00871]
         Fluphenazine [DG:DG00874]
         Perphenazine [DG:DG00875]
         Prochlorperazine [DG:DG00876]
         Trifluoperazine [DG:DG00877]
         Thioproperazine [DG:DG00879]
         Thioridazine [DG:DG00882]
         Haloperidol [DG:DG00885]
         Trifluperidol [DG:DG00886]
         Moperone [DG:DG00888]
         Pipamperone [DG:DG00889]
         Bromperidol [DG:DG00890]
         Molindone [DG:DG00891]
         Ziprasidone [DG:DG00892]
         Flupentixol [DG:DG00893]
         Tiotixene [DG:DG00895]
         Zuclopenthixol [DG:DG00896]
         Loxapine [DG:DG00897]
         Olanzapine [DG:DG00898]
         Quetiapine [DG:DG00899]
         Sultopride [DG:DG00900]
         Tiapride [DG:DG00901]
         Remoxipride [DG:DG00902]
         Mosapramine [DG:DG00905]
         Paliperidone [DG:DG00907]
         Aripiprazole [DG:DG00906]
         Opipramol [DG:DG00930]
         Bifeprunox [DH:DG01304]
         Cariprazine [DG:DG01305]
         Clocapramine [DG:DG01313]
         Lergotrile [DG:DG01319]
         Pardoprunox [DG:DG01324]
         Pridopidine [DG:DG01325]
         Talipexole [DG:DG01326]
         Aplindore
         Asenapine
         Blonanserin
         Brexpiprazole
         Bromopride
         Butaclamol
         Cabergoline
         Carvotroline
         Ciladopa
         Clopenthixol
         Clozapine
         Dopexamine
         Droperidol
         Ergot alkaloids
         Gevotroline
         Iloperidone
         Levodopa
         Levosulpiride
         Lurasidone
         Mazapertine
         Methoxypromazine
         Metopimazine
         Nemonapride
         Oxiperomide
         Perospirone
         Periciazine
         Pimozide
         Piquindone
         Piribedil
         Promazine
         Quinelorane
         Quinpirole
         Raclopride C11
         Risperidone
         Rotigotine
         Sertindole
         Sibenadet
         Spiperone
         Sulpiride
         Terguride
         Timiperone
         Tiospirone
         Zotepine
       dopamine D3-receptor [HSA:1814] [KO:K04146]
       dopamine D4-receptor [HSA:1815] [KO:K04147]
       dopamine D5-receptor [HSA:1816] [KO:K05840]
     Histamine
     Serotonin
       5-HT1A-receptor [HSA:3350] [KO:K04153]
       5-HT1B-receptor [HSA:3351] [KO:K04153]
       5-HT1D-receptor [HSA:3352] [KO:K04153]
       5-HT1E-receptor [HSA:3354] [KO:K04153]
       5-HT1F-receptor [HSA:3355] [KO:K04153]
       5-HT1-receptor [HSA:3350 3351 3352 3354 3355] [KO:K04153]
         Methylergometrine [DG:DG00445]
         Ergometrine [DG:DG00446]
           D07905  Ergometrine (INN)
           D01163  Ergonovine maleate (USP)
Agonist/Antagonist
Agonist/Antagonist
         Pizotifen [DG:DG00842]
         Mianserin [DG:DG00951]
         Vilazodone [DG:DG00964]
         Asenapine
         Ergot alkaloids
         Indorenate
         Metergoline
       5-HT2A-receptor [HSA:3356] [KO:K04157]
       5-HT2B-receptor [HSA:3357] [KO:K04157]
       5-HT2C-receptor [HSA:3358] [KO:K04157]
       5-HT2-receptor [HSA:3356 3357 3358] [KO:K04157]
       5-HT3-receptor [HSA:3359 9177 170572 200909 285242] [KO:K04819]
       5-HT4-receptor [HSA:3360] [KO:K04160]
       5-HT5-receptor [HSA:3361] [KO:K04161]
       5-HT6-receptor [HSA:3362] [KO:K04162]
       5-HT7-receptor [HSA:3363] [KO:K04163]
     Tachykinin / neurokinin
     Ghrelin
     Orexin
     Neuropeptide Y
     Opioid
     Angiotensin
     Bradykinin
     Endothelin
     Lutropin-choriogonadotropic hormone
     Follicle stimulating hormone
     Oxytocin
     Vasopressin
     Melanocortin
     Gonadotropin-releasing hormone
     Somatostatin
     Thyrotropin-releasing hormone
     Cholecystokinin
     Motilin
     Thrombin
     Purine / pyrimidine
     Adenosine
     Prostaglandin
     Prostacyclin
     Leukotriene
     Thromboxane
     Sphingolipid
     Free fatty acid
     Cannabinoid
     Platelet activating factor
     Melatonin
     Cysteinyl leukotriene
   Secretin receptor family
   Metabotropic glutamate receptor family
   Others
 
 Cytokine receptors
 
 Nuclear receptors
 
 Ion channels
 
 Transporters
 
 Enzymes
 
 Protein kinases
 
 Cytokines
 
 Others

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Last updated: November 7, 2014

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