Target-based Classification of Drugs

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     Remark
 G Protein-coupled receptors
   Rhodopsin family
     Acetylcholine (muscarinic)
     Adrenaline
       alpha1a-adrenergic receptor [HSA:148] [KO:K04135]
       alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
         Epinephrine [DG:DG00013]
         Adrenalone [DG:DG00016]
         Etilefrine [DG:DG00210]
         Norepinephrine [DG:DG00212]
         Norfenefrine [DG:DG00214]
         Phenylephrine [DG:DG00215]
         Oxedrine [DG:DG00217]
         Metaraminol [DG:DG00218]
         Methoxamine [DG:DG00219]
         Midodrine [DG:DG00224]
         Ephedrine [DG:DG00227]
         Prazosin [DG:DG00253]
         Indoramin [DG:DG00254]
         Trimazosin [DG:DG00255]
         Doxazosin [DG:DG00256]
         Urapidil [DG:DG00257]
         Ketanserin [DG:DG00265]
         Phentolamine [DG:DG00280]
         Tolazoline [DG:DG00281]
         Nicergoline [DG:DG00283]
         Phenoxybenzamine [DG:DG00285]
         Moxisylyte [DG:DG00287]
         Ifenprodil [DG:DG00292]
         Labetalol [DG:DG00320]
         Carvedilol [DG:DG00321]
         Methylergometrine [DG:DG00445]
         Ergometrine [DG:DG00446]
         Alfuzosin [DG:DG00489]
         Tamsulosin [DG:DG00490]
         Terazosin [DG:DG00491]
         Dihydroergotamine [DG:DG00833]
         Ergotamine [DG:DG00834]
         Levomepromazine [DG:DG00868]
         Olanzapine [DG:DG00898]
         Quetiapine [DG:DG00899]
         Mianserin [DG:DG00951]
         Oxymetazoline [DG:DG01029]
         Tetryzoline [DG:DG01030]
         Xylometazoline [DG:DG01031]
         Naphazoline [DG:DG01032]
         Tramazoline [DG:DG01033]
         Pseudoephedrine [DG:DG01042]
         Dipivefrine [DG:DG01129]
         Methylephedrine [DG:DG01229]
           D08206  Methylephedrine (BAN)
           D01952  L-Methylephedrine hydrochloride (JAN)
           D02109  dl-Methylephedrine hydrochloride (JP16)
           D09842  dl-Methylephedrine saccharinate (JAN)
Agonist
Agonist
Agonist
Agonist
         Setiptiline [DG:DG01231]
         Amosulalol [DG:DG01302]
         Arotinolol [DG:DG01303]
         Bunazosin [DG:DG01316]
         Medroxalol [DG:DG01317]
         Arbutamine
         Ergot alkaloids
         Silodosin
         Sertindole
         Pimozide
         Clozapine
         Asenapine
         Risperidone
         Dapiprazole
         Amidephrine
         Bunitrolol
         Guanadrel
         Naftopidil
         Pelanserin
       alpha2b-adrenergic receptor [HSA:151] [KO:K04139]
       alpha2-adrenergic receptor [HSA:150 151 152] [KO:K04138 K04139 K04140]
         Epinephrine [DG:DG00013]
         Norepinephrine [DG:DG00212]
         Oxedrine [DG:DG00217]
         Metaraminol [DG:DG00218]
         Ephedrine [DG:DG00227]
         Methyldopa (levorotatory) [DG:DG00248]
         Clonidine [DG:DG00249]
         Guanfacine [DG:DG00250]
         Phentolamine [DG:DG00280]
         Tolazoline [DG:DG00281]
         Phenoxybenzamine [DG:DG00285]
         Methylergometrine [DG:DG00445]
         Ergometrine [DG:DG00446]
         Yohimbin [DG:DG00485]
         Tizanidine [DG:DG00773]
         Chlorpromazine [DG:DG00867]
         Levomepromazine [DG:DG00868]
         Dexmedetomidine [DG:DG00926]
         Mianserin [DG:DG00951]
         Pseudoephedrine [DG:DG01042]
         Dipivefrine [DG:DG01129]
         Methylephedrine [DG:DG01229]
           D08206  Methylephedrine (BAN)
           D01952  L-Methylephedrine hydrochloride (JAN)
           D02109  dl-Methylephedrine hydrochloride (JP16)
           D09842  dl-Methylephedrine saccharinate (JAN)
Agonist
Agonist
Agonist
Agonist
         Apraclonidine [DG:DG01130]
         Setiptiline [DG:DG01231]
         Detomidine [DG:DG01318]
         Guanabenz [DG:DG01319]
         Medetomidine [DG:DG01320]
         Xylazine; Veterinary [DG:DG01321]
         Rilmenidine
         Ergot alkaloids
         Piribedil
         Asenapine
         Mirtazapine
         Brimonidine
         Dapiprazole
         Aptazapine
         Atipamezole
         Delequamine
         Fluparoxan
         Guanadrel
         Levonordefrin
         Romifidine
       beta1-adrenergic receptor [HSA:153] [KO:K04141]
         Epinephrine [DG:DG00013]
         Isoprenaline [DG:DG00211]
         Norepinephrine [DG:DG00212]
         Dobutamine [DG:DG00216]
         Ephedrine [DG:DG00227]
         Xamoterol [DG:DG00231]
         Buphenine [DG:DG00278]
         Alprenolol [DG:DG00303]
         Oxprenolol [DG:DG00304]
         Propranolol [DG:DG00305]
         Timolol [DG:DG00306]
         Sotalol [DG:DG00307]
         Carteolol [DG:DG00308]
         Tertatolol [DG:DG00309]
         Bopindolol [DG:DG00310]
         Bupranolol [DG:DG00311]
         Penbutolol [DG:DG00312]
         Metoprolol [DG:DG00313]
         Acebutolol [DG:DG00314]
         Betaxolol [DG:DG00315]
         Bisoprolol [DG:DG00316]
         Celiprolol [DG:DG00317]
         Esmolol [DG:DG00318]
         Nebivolol [DG:DG00319]
         Labetalol [DG:DG00320]
         Carvedilol [DG:DG00321]
         Pseudoephedrine [DG:DG01042]
         Dipivefrine [DG:DG01129]
         Levobunolol [DG:DG01136]
         Metipranolol [DG:DG01137]
         Befunolol [DG:DG01138]
         Methylephedrine [DG:DG01229]
           D08206  Methylephedrine (BAN)
           D01952  L-Methylephedrine hydrochloride (JAN)
           D02109  dl-Methylephedrine hydrochloride (JP16)
           D09842  dl-Methylephedrine saccharinate (JAN)
Agonist
Agonist
Agonist
Agonist
         Amosulalol [DG:DG01302]
         Arotinolol [DG:DG01303]
         Medroxalol [DG:DG01317]
         Tilisolol [DG:DG01322]
         Indenolol [DG:DG01323]
         Arbutamine
         Pindolol
         Nadolol
         Mepindolol
         Cloranolol
         Practolol
         Atenolol
         Bevantolol
         Epanolol
         S-atenolol
         Talinolol
         Adaprolol
         Alprenoxime
         Bucindolol
         Bucumolol
         Bufetolol
         Bunitrolol
         Bunolol
         Butopamine
         Cetamolol
         Cicloprolol
         Cimaterol
         Denopamine
         Dexpropranolol
         Diacetolol
         Flestolol
         Landiolol
         Levdobutamine
         Levobetaxolol
         Nipradilol
         Pamatolol
         Primidolol
         Prenalterol
         Talibegron
       beta2-adrenergic receptor [HSA:154] [KO:K04142]
         Epinephrine [DG:DG00013]
         Isoprenaline [DG:DG00211]
         Norepinephrine [DG:DG00212]
         Ephedrine [DG:DG00227]
         Isoxsuprine [DG:DG00277]
         Buphenine [DG:DG00278]
         Alprenolol [DG:DG00303]
         Oxprenolol [DG:DG00304]
         Propranolol [DG:DG00305]
         Timolol [DG:DG00306]
         Sotalol [DG:DG00307]
         Carteolol [DG:DG00308]
         Tertatolol [DG:DG00309]
         Bopindolol [DG:DG00310]
         Bupranolol [DG:DG00311]
         Penbutolol [DG:DG00312]
         Labetalol [DG:DG00320]
         Carvedilol [DG:DG00321]
         Ritodrine [DG:DG00450]
         Fenoterol [DG:DG00451]
         Pseudoephedrine [DG:DG01042]
         Orciprenaline [DG:DG01044]
         Terbutaline [DG:DG01046]
         Hexoprenaline [DG:DG01047]
         Pirbuterol [DG:DG01048]
         Tretoquinol [DG:DG01049]
         Tulobuterol [DG:DG01050]
         Salmeterol [DG:DG01051]
         Formoterol [DG:DG01052]
         Clenbuterol [DG:DG01053]
         Reproterol [DG:DG01054]
         Procaterol [DG:DG01055]
         Bitolterol [DG:DG01056]
         Indacaterol [DG:DG01057]
         Olodaterol [DG:DG01058]
         Bambuterol [DG:DG01060]
         Dipivefrine[DG:DG01129]
         Levobunolol [DG:DG01136]
         Metipranolol [DG:DG01137]
         Befunolol [DG:DG01138]
         Methylephedrine [DG:DG01229]
           D08206  Methylephedrine (BAN)
           D01952  L-Methylephedrine hydrochloride (JAN)
           D02109  dl-Methylephedrine hydrochloride (JP16)
           D09842  dl-Methylephedrine saccharinate (JAN)
Agonist
Agonist
Agonist
Agonist
         Abediterol [DG:DG01232]
         Arformoterol [DG:DG01233]
         Levalbuterol [DG:DG01235]
         Amosulalol [DG:DG01302]
         Arotinolol [DG:DG01303]
         Indenolol [DG:DG01323]
         Isoetharine [DG:DG01234]
         Medroxalol [DG:DG01317]
         Tilisolol [DG:DG01322]
         Vilanterol [DG:DG01236]
         Adaprolol
         Albuterol
         Alprenoxime
         Arbutamine
         Bucindolol
         Bucumolol
         Bufetolol
         Bunitrolol
         Bunolol
         Butoxamine
         Carbuterol
         Carazolol
         Cetamolol
         Cicloprolol
         Cimaterol
         Cloranolol
         Clorprenaline
         Colterol
         Dexpropranolol
         Diacetolol
         Dopexamine
         Flestolol
         Levosalbutamol
         Mabuterol
         Mepindolol
         Metaproterenol
         Methoxyphenamine
         Milveterol
         Nadolol
         Nipradilol
         Pamatolol
         Picumeterol
         Primidolol
         Pindolol
         Ractopamine
         Rimiterol
         Salbutamol
         Sibenadet
         Soterenol
         Talibegron
         Zinterol
       beta3-adrenergic receptor [HSA:155] [KO:K04143]
         Epinephrine [DG:DG00013]
         Isoprenaline [DG:DG00211]
         Norepinephrine [DG:DG00212]
         Ephedrine [DG:DG00227]
         Buphenine [DG:DG00278]
         Alprenolol [DG:DG00303]
         Oxprenolol [DG:DG00304]
         Propranolol [DG:DG00305]
         Timolol [DG:DG00306]
         Carteolol [DG:DG00308]
         Tertatolol [DG:DG00309]
         Bopindolol [DG:DG00310]
         Bupranolol [DG:DG00311]
         Penbutolol [DG:DG00312]
         Labetalol [DG:DG00320]
         Carvedilol [DG:DG00321]
         Pseudoephedrine [DG:DG01042]
         Dipivefrin [DG:DG01129]
         Levobunolol [DG:DG01136]
         Metipranolol [DG:DG01137]
         Befunolol [DG:DG01138]
         Methylephedrine [DG:DG01229]
           D08206  Methylephedrine (BAN)
           D01952  L-Methylephedrine hydrochloride (JAN)
           D02109  dl-Methylephedrine hydrochloride (JP16)
           D09842  dl-Methylephedrine saccharinate (JAN)
Agonist
Agonist
Agonist
Agonist
         Amibegron [DG:DG01237]
         Amosulalol [DG:DG01302]
         Arotinolol [DG:DG01303]
         Medroxalol [DG:DG01317]
         Tilisolol [DG:DG01322]
         Adaprolol
         Alprenoxime
         Arbutamine
         Bucindolol
         Bufetolol
         Bunitrolol
         Bunolol
         Cetamolol
         Cicloprolol
         Cimaterol
         Cloranolol
         Dexpropranolol
         Diacetolol
         Fasobegron
         Flestolol
         Mepindolol
         Mirabegron
         Nadolol
         Nipradilol
         Pamatolol
         Pindolol
         Primidolol
         Ritobegron
         Solabegron
         Talibegron
     Dopamine
     Histamine
     Serotonin
     Tachykinin / neurokinin
     Ghrelin
     Orexin
     Neuropeptide Y
     Opioid
     Angiotensin
     Bradykinin
     Endothelin
     Lutropin-choriogonadotropic hormone
     Follicle stimulating hormone
     Oxytocin
     Vasopressin
     Melanocortin
     Gonadotropin-releasing hormone
     Somatostatin
     Thyrotropin-releasing hormone
     Cholecystokinin
     Motilin
     Thrombin
     Purine / pyrimidine
     Adenosine
     Prostaglandin
     Prostacyclin
     Leukotriene
     Thromboxane
     Sphingolipid
     Free fatty acid
     Cannabinoid
     Platelet activating factor
     Melatonin
     Cysteinyl leukotriene
   Secretin receptor family
   Metabotropic glutamate receptor family
   Others
 
 Cytokine receptors
 
 Nuclear receptors
 
 Ion channels
 
 Transporters
 
 Enzymes
 
 Protein kinases
 
 Cytokines
 
 Others

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Last updated: September 11, 2014

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