Target-based Classification of Drugs

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     Remark
 G Protein-coupled receptors
 
 Cytokine receptors
   Class I cytokine receptors (hematopoietin family receptors)
   Class II cytokine receptors (interferon/IL-10 family receptors)
   Receptor tyrosine kinase
     RTK class I (EGF receptor family)
     RTK class II (Insulin receptor family)
     RTK class III (PDGF receptor family)
       PDGFRA tyrosine kinase [HSA:5156] [KO:K04363]
         Imatinib [DG:DG00710]
         Sunitinib [DG:DG00712]
         Nilotinib [DG:DG00716]
         Cediranib [DG:DG01360]
         Crenolanib [DG:DG01361]
         Lenvatinib [DG:DG01362]
         Motesanib [DG:DG01262]
           D06678  Motesanib
           D08947  Motesanib diphosphate (USAN)
Inhibitor
Inhibitor
         Toceranib [DG:DG01363]
         Cabozantinib
         Linifanib
         Nintedanib
         Olaratumab
         Pazopanib
         Tovetumab
       PDGFRB tyrosine kinase [HSA:5159] [KO:K05089]
         Becaplermin
         Imatinib [DG:DG00710]
         Sunitinib [DG:DG00712]
         Sorafenib [DG:DG00713]
         Dasatinib [DG:DG00714]
         Nilotinib [DG:DG00716]
         Regorafenib [DG:DG00720]
         Motesanib [DG:DG01262]
           D06678  Motesanib
           D08947  Motesanib diphosphate (USAN)
Inhibitor
Inhibitor
         Cediranib [DG:DG01360]
         Crenolanib [DG:DG01361]
         Lenvatinib [DG:DG01362]
         Toceranib [DG:DG01363]
         Axitinib
         Cabozantinib
         Dovitinib
         Linifanib
         Midostaurin
         Nintedanib
         Pazopanib
         Tandutinib
         Vatalanib
       c-KIT tyrosine kinase [HSA:3815] [KO:K05091]
       Fms-related tyrosine kinase 3 [HSA:2322] [KO:K05092]
     RTK class IV (FGF receptor family)
     RTK class V (VEGF receptor family)
       VEGFR1 tyrosine kinase [HSA:2321] [KO:K05096]
         Sunitinib [DG:DG00712]
         Regorafenib [DG:DG00720]
         Motesanib [DG:DG01262]
           D06678  Motesanib
           D08947  Motesanib diphosphate (USAN)
Inhibitor
Inhibitor
         Cediranib [DG:DG01360]
         Lenvatinib [DG:DG01362]
         Toceranib [DG:DG01363]
         Tivozanib [DG:DG01375]
         Pazopanib
         Axitinib
         Cabozantinib
         Dovitinib
         Icrucumab
         Linifanib
         Nintedanib
         Vatalanib
       VEGFR2 tyrosine kinase [HSA:3791] [KO:K05098]
         Sunitinib [DG:DG00712]
         Sorafenib [DG:DG00713]
         Motesanib [DG:DG01262]
           D06678  Motesanib
           D08947  Motesanib diphosphate (USAN)
Inhibitor
Inhibitor
         Cediranib [DG:DG01360]
         Toceranib [DG:DG01363]
         Golvatinib [DG:DG01367]
         Brivanib [DG:DG01373]
         Tivozanib [DG:DG01375]
         Pazopanib
         Vandetanib
         Axitinib
         Cabozantinib
         Dovitinib
         Foretinib
         Linifanib
         Midostaurin
         Nintedanib
         Pegdinetanib
         Ramucirumab
         Vatalanib
         Semaxanib
       VEGFR3 tyrosine kinase [HSA:2324] [KO:K05097]
         Sunitinib [DG:DG00712]
         Sorafenib [DG:DG00713]
         Regorafenib [DG:DG00720]
         Motesanib [DG:DG01262]
           D06678  Motesanib
           D08947  Motesanib diphosphate (USAN)
Inhibitor
Inhibitor
         Cediranib [DG:DG01360]
         Toceranib [DG:DG01363]
         Tivozanib [DG:DG01375]
         Pazopanib
         Axitinib
         Cabozantinib
         Dovitinib
         Linifanib
         Nintedanib
         Vatalanib
     RTK class VI (HGF receptor family)
     RTK class VIII (EPH receptor family)
     RTK class X (LTK receptor family)
     RTK class XIV (RET receptor family)
   TNF receptor family
   IL-1 receptor family
   IL-17 receptor family
   TGF-beta receptors
   Chemokine receptors
 
 Nuclear receptors
 
 Ion channels
 
 Transporters
 
 Enzymes
 
 Protein kinases
 
 Cytokines
 
 Others

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Last updated: November 7, 2014

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