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KO |
09100 Metabolism
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09120 Genetic Information Processing
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09130 Environmental Information Processing
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09140 Cellular Processes
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09141 Transport and catabolism
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09143 Cell growth and death
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04110 Cell cycle [PATH:hsa04110]
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04111 Cell cycle - yeast
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04112 Cell cycle - Caulobacter
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04113 Meiosis - yeast
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04114 Oocyte meiosis [PATH:hsa04114]
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04210 Apoptosis [PATH:hsa04210]
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8743 TNFSF10; TNF superfamily member 10
8797 TNFRSF10A; TNF receptor superfamily member 10a
8795 TNFRSF10B; TNF receptor superfamily member 10b
356 FASLG; Fas ligand
355 FAS; Fas cell surface death receptor
8772 FADD; Fas associated via death domain
7124 TNF; tumor necrosis factor
7132 TNFRSF1A; TNF receptor superfamily member 1A
8717 TRADD; TNFRSF1A associated via death domain
8837 CFLAR; CASP8 and FADD like apoptosis regulator
841 CASP8; caspase 8
843 CASP10; caspase 10
839 CASP6; caspase 6
836 CASP3; caspase 3
840 CASP7; caspase 7
637 BID; BH3 interacting domain death agonist
581 BAX; BCL2 associated X, apoptosis regulator
578 BAK1; BCL2 antagonist/killer 1
56616 DIABLO; diablo IAP-binding mitochondrial protein
5414 SEPTIN4; septin 4
27429 HTRA2; HtrA serine peptidase 2
54205 CYCS; cytochrome c, somatic
317 APAF1; apoptotic peptidase activating factor 1
842 CASP9; caspase 9
5551 PRF1; perforin 1
3002 GZMB; granzyme B
10376 TUBA1B; tubulin alpha 1b
7277 TUBA4A; tubulin alpha 4a
7278 TUBA3C; tubulin alpha 3c
7846 TUBA1A; tubulin alpha 1a
84790 TUBA1C; tubulin alpha 1c
51807 TUBA8; tubulin alpha 8
112714 TUBA3E; tubulin alpha 3e
113457 TUBA3D; tubulin alpha 3d
79861 TUBAL3; tubulin alpha like 3
4170 MCL1; MCL1 apoptosis regulator, BCL2 family member
71 ACTG1; actin gamma 1
60 ACTB; actin beta
6708 SPTA1; spectrin alpha, erythrocytic 1
6709 SPTAN1; spectrin alpha, non-erythrocytic 1
4000 LMNA; lamin A/C
4001 LMNB1; lamin B1
84823 LMNB2; lamin B2
142 PARP1; poly(ADP-ribose) polymerase 1
10038 PARP2; poly(ADP-ribose) polymerase 2
10039 PARP3; poly(ADP-ribose) polymerase family member 3
143 PARP4; poly(ADP-ribose) polymerase family member 4
1676 DFFA; DNA fragmentation factor subunit alpha
1677 DFFB; DNA fragmentation factor subunit beta
2021 ENDOG; endonuclease G
9131 AIFM1; apoptosis inducing factor mitochondria associated 1
2081 ERN1; endoplasmic reticulum to nucleus signaling 1
7186 TRAF2; TNF receptor associated factor 2
3708 ITPR1; inositol 1,4,5-trisphosphate receptor type 1
3709 ITPR2; inositol 1,4,5-trisphosphate receptor type 2
3710 ITPR3; inositol 1,4,5-trisphosphate receptor type 3
823 CAPN1; calpain 1
824 CAPN2; calpain 2
100506742 CASP12; caspase 12 (gene/pseudogene)
9451 EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3
1965 EIF2S1; eukaryotic translation initiation factor 2 subunit alpha
468 ATF4; activating transcription factor 4
1649 DDIT3; DNA damage inducible transcript 3
1508 CTSB; cathepsin B
1075 CTSC; cathepsin C
1509 CTSD; cathepsin D
8722 CTSF; cathepsin F
1512 CTSH; cathepsin H
1513 CTSK; cathepsin K
1514 CTSL; cathepsin L
1519 CTSO; cathepsin O
1520 CTSS; cathepsin S
1515 CTSV; cathepsin V
1521 CTSW; cathepsin W
1522 CTSZ; cathepsin Z
329 BIRC2; baculoviral IAP repeat containing 2
330 BIRC3; baculoviral IAP repeat containing 3
331 XIAP; X-linked inhibitor of apoptosis
332 BIRC5; baculoviral IAP repeat containing 5
10018 BCL2L11; BCL2 like 11
598 BCL2L1; BCL2 like 1
596 BCL2; BCL2 apoptosis regulator
1616 DAXX; death domain associated protein
8737 RIPK1; receptor interacting serine/threonine kinase 1
153090 DAB2IP; DAB2 interacting protein
4217 MAP3K5; mitogen-activated protein kinase kinase kinase 5
5599 MAPK8; mitogen-activated protein kinase 8
5602 MAPK10; mitogen-activated protein kinase 10
5601 MAPK9; mitogen-activated protein kinase 9
572 BAD; BCL2 associated agonist of cell death
3725 JUN; Jun proto-oncogene, AP-1 transcription factor subunit
2353 FOS; Fos proto-oncogene, AP-1 transcription factor subunit
7157 TP53; tumor protein p53
8739 HRK; harakiri, BCL2 interacting protein
9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14
1147 CHUK; component of inhibitor of nuclear factor kappa B kinase complex
3551 IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517 IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
4792 NFKBIA; NFKB inhibitor alpha
4790 NFKB1; nuclear factor kappa B subunit 1
5970 RELA; RELA proto-oncogene, NF-kB subunit
5783 PTPN13; protein tyrosine phosphatase non-receptor type 13
1647 GADD45A; growth arrest and DNA damage inducible alpha
4616 GADD45B; growth arrest and DNA damage inducible beta
10912 GADD45G; growth arrest and DNA damage inducible gamma
7185 TRAF1; TNF receptor associated factor 1
597 BCL2A1; BCL2 related protein A1
472 ATM; ATM serine/threonine kinase
55367 PIDD1; p53-induced death domain protein 1
63970 TP53AIP1; tumor protein p53 regulated apoptosis inducing protein 1
27113 BBC3; BCL2 binding component 3
5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
835 CASP2; caspase 2
4803 NGF; nerve growth factor
4914 NTRK1; neurotrophic receptor tyrosine kinase 1
3562 IL3; interleukin 3
3563 IL3RA; interleukin 3 receptor subunit alpha
1439 CSF2RB; colony stimulating factor 2 receptor subunit beta
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
5170 PDPK1; 3-phosphoinositide dependent protein kinase 1
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
3265 HRAS; HRas proto-oncogene, GTPase
3845 KRAS; KRAS proto-oncogene, GTPase
4893 NRAS; NRAS proto-oncogene, GTPase
5894 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604 MAP2K1; mitogen-activated protein kinase kinase 1
5605 MAP2K2; mitogen-activated protein kinase kinase 2
5594 MAPK1; mitogen-activated protein kinase 1
5595 MAPK3; mitogen-activated protein kinase 3
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K04721 TNFSF10; tumor necrosis factor ligand superfamily member 10
K04722 TNFRSF10A_B; tumor necrosis factor receptor superfamily member 10A/B
K04722 TNFRSF10A_B; tumor necrosis factor receptor superfamily member 10A/B
K04389 TNFSF6; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6; tumor necrosis factor receptor superfamily member 6
K02373 FADD; FAS-associated death domain protein
K03156 TNF; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K04724 CFLAR; CASP8 and FADD-like apoptosis regulator
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04400 CASP10; caspase 10 [EC:3.4.22.63]
K04396 CASP6; caspase 6 [EC:3.4.22.59]
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04397 CASP7; caspase 7 [EC:3.4.22.60]
K04726 BID; BH3 interacting domain death agonist
K02159 BAX; apoptosis regulator BAX
K14021 BAK; Bcl-2 homologous antagonist/killer
K10522 DIABLO; diablo
K16943 SEPT4; septin 4
K08669 HTRA2; HtrA serine peptidase 2 [EC:3.4.21.108]
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K07818 PRF1; perforin 1
K01353 GZMB; granzyme B [EC:3.4.21.79]
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K02539 MCL1; myeloid leukemia cell differntiation protein MCL-1
K05692 ACTB_G1; actin beta/gamma 1
K05692 ACTB_G1; actin beta/gamma 1
K06114 SPTA; spectrin alpha
K06114 SPTA; spectrin alpha
K12641 LMNA; lamin A/C
K07611 LMNB; lamin B
K07611 LMNB; lamin B
K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
K02310 DFFA; DNA fragmentation factor, 45 kD, alpha subunit
K02311 DFFB; DNA fragmentation factor, 40 kD, beta subunit [EC:3.-.-.-]
K01173 ENDOG; endonuclease G, mitochondrial
K04727 AIFM1; apoptosis-inducing factor 1 [EC:1.-.-.-]
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]
K03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K04958 ITPR1; inositol 1,4,5-triphosphate receptor type 1
K04959 ITPR2; inositol 1,4,5-triphosphate receptor type 2
K04960 ITPR3; inositol 1,4,5-triphosphate receptor type 3
K01367 CAPN1; calpain-1 [EC:3.4.22.52]
K03853 CAPN2; calpain-2 [EC:3.4.22.53]
K04741 CASP12; caspase 12 [EC:3.4.22.-]
K08860 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
K03237 EIF2S1; translation initiation factor 2 subunit 1
K04374 ATF4; cyclic AMP-dependent transcription factor ATF-4
K04452 DDIT3; DNA damage-inducible transcript 3
K01363 CTSB; cathepsin B [EC:3.4.22.1]
K01275 CTSC; cathepsin C [EC:3.4.14.1]
K01379 CTSD; cathepsin D [EC:3.4.23.5]
K01373 CTSF; cathepsin F [EC:3.4.22.41]
K01366 CTSH; cathepsin H [EC:3.4.22.16]
K01371 CTSK; cathepsin K [EC:3.4.22.38]
K01365 CTSL; cathepsin L [EC:3.4.22.15]
K01374 CTSO; cathepsin O [EC:3.4.22.42]
K01368 CTSS; cathepsin S [EC:3.4.22.27]
K01375 CTSL2; cathepsin V [EC:3.4.22.43]
K08569 CTSW; cathepsin W [EC:3.4.22.-]
K08568 CTSZ; cathepsin X [EC:3.4.18.1]
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K16341 BCL2L11; Bcl-2-like protein 11
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K02161 BCL2; apoptosis regulator Bcl-2
K02308 DAXX; death-associated protein 6
K02861 RIPK1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
K19901 DAB2IP; disabled homolog 2-interacting protein
K04426 MAP3K5; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K02158 BAD; Bcl-2-antagonist of cell death
K04448 JUN; transcription factor AP-1
K04379 FOS; proto-oncogene protein c-fos
K04451 TP53; tumor protein p53
K02512 HRK; activator of apoptosis harakiri
K04466 MAP3K14; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
K04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K02374 PTPN13; tyrosine-protein phosphatase non-receptor type 13
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K03172 TRAF1; TNF receptor-associated factor 1
K02162 BCL2A1; hematopoietic Bcl-2-related protein A1
K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
K10130 LRDD; leucine-rich repeats and death domain-containing protein
K13773 TP53AIP1; p53-regulated apoptosis-inducing protein 1
K10132 BBC3; Bcl-2-binding component 3
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K02186 CASP2; caspase 2 [EC:3.4.22.55]
K02582 NGFB; nerve growth factor, beta
K03176 NTRK1; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K04736 IL3; interleukin 3
K04737 IL3RA; interleukin 3 receptor alpha
K04738 CSF2RB; cytokine receptor common subunit beta
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
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04214 Apoptosis - fly
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04215 Apoptosis - multiple species [PATH:hsa04215]
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7132 TNFRSF1A; TNF receptor superfamily member 1A
8772 FADD; Fas associated via death domain
841 CASP8; caspase 8
840 CASP7; caspase 7
836 CASP3; caspase 3
637 BID; BH3 interacting domain death agonist
10018 BCL2L11; BCL2 like 11
5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
27113 BBC3; BCL2 binding component 3
596 BCL2; BCL2 apoptosis regulator
598 BCL2L1; BCL2 like 1
581 BAX; BCL2 associated X, apoptosis regulator
578 BAK1; BCL2 antagonist/killer 1
54205 CYCS; cytochrome c, somatic
317 APAF1; apoptotic peptidase activating factor 1
842 CASP9; caspase 9
56616 DIABLO; diablo IAP-binding mitochondrial protein
27429 HTRA2; HtrA serine peptidase 2
5414 SEPTIN4; septin 4
329 BIRC2; baculoviral IAP repeat containing 2
330 BIRC3; baculoviral IAP repeat containing 3
331 XIAP; X-linked inhibitor of apoptosis
332 BIRC5; baculoviral IAP repeat containing 5
5599 MAPK8; mitogen-activated protein kinase 8
5602 MAPK10; mitogen-activated protein kinase 10
5601 MAPK9; mitogen-activated protein kinase 9
666 BOK; BCL2 family apoptosis regulator BOK
79444 BIRC7; baculoviral IAP repeat containing 7
4804 NGFR; nerve growth factor receptor
8678 BECN1; beclin 1
441925 BECN2; beclin 2
57448 BIRC6; baculoviral IAP repeat containing 6
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K03158 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A
K02373 FADD; FAS-associated death domain protein
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04397 CASP7; caspase 7 [EC:3.4.22.60]
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04726 BID; BH3 interacting domain death agonist
K16341 BCL2L11; Bcl-2-like protein 11
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K10132 BBC3; Bcl-2-binding component 3
K02161 BCL2; apoptosis regulator Bcl-2
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K02159 BAX; apoptosis regulator BAX
K14021 BAK; Bcl-2 homologous antagonist/killer
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K10522 DIABLO; diablo
K08669 HTRA2; HtrA serine peptidase 2 [EC:3.4.21.108]
K16943 SEPT4; septin 4
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K02561 BOK; Bcl-2-related ovarian killer protein
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K02583 NGFR; tumor necrosis factor receptor superfamily member 16
K08334 BECN; beclin
K08334 BECN; beclin
K10586 BIRC6; baculoviral IAP repeat-containing protein 6 (apollon) [EC:2.3.2.23]
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04216 Ferroptosis [PATH:hsa04216]
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04217 Necroptosis [PATH:hsa04217]
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04115 p53 signaling pathway [PATH:hsa04115]
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472 ATM; ATM serine/threonine kinase
11200 CHEK2; checkpoint kinase 2
545 ATR; ATR serine/threonine kinase
1111 CHEK1; checkpoint kinase 1
92344 GORAB; golgin, RAB6 interacting
1029 CDKN2A; cyclin dependent kinase inhibitor 2A
4193 MDM2; MDM2 proto-oncogene
4194 MDM4; MDM4 regulator of p53
7157 TP53; tumor protein p53
10848 PPP1R13L; protein phosphatase 1 regulatory subunit 13 like
1026 CDKN1A; cyclin dependent kinase inhibitor 1A
595 CCND1; cyclin D1
894 CCND2; cyclin D2
896 CCND3; cyclin D3
1019 CDK4; cyclin dependent kinase 4
1021 CDK6; cyclin dependent kinase 6
898 CCNE1; cyclin E1
9134 CCNE2; cyclin E2
1017 CDK2; cyclin dependent kinase 2
2810 SFN; stratifin
56475 RPRM; reprimo, TP53 dependent G2 arrest mediator homolog
891 CCNB1; cyclin B1
9133 CCNB2; cyclin B2
983 CDK1; cyclin dependent kinase 1
1647 GADD45A; growth arrest and DNA damage inducible alpha
4616 GADD45B; growth arrest and DNA damage inducible beta
10912 GADD45G; growth arrest and DNA damage inducible gamma
51512 GTSE1; G2 and S-phase expressed 1
25946 ZNF385A; zinc finger protein 385A
355 FAS; Fas cell surface death receptor
55367 PIDD1; p53-induced death domain protein 1
8797 TNFRSF10A; TNF receptor superfamily member 10a
8795 TNFRSF10B; TNF receptor superfamily member 10b
841 CASP8; caspase 8
637 BID; BH3 interacting domain death agonist
581 BAX; BCL2 associated X, apoptosis regulator
5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
27113 BBC3; BCL2 binding component 3
63970 TP53AIP1; tumor protein p53 regulated apoptosis inducing protein 1
10572 SIVA1; SIVA1 apoptosis inducing factor
598 BCL2L1; BCL2 like 1
596 BCL2; BCL2 apoptosis regulator
9540 TP53I3; tumor protein p53 inducible protein 3
9538 EI24; EI24 autophagy associated transmembrane protein
51246 SHISA5; shisa family member 5
64065 PERP; p53 apoptosis effector related to PMP22
64393 ZMAT3; zinc finger matrin-type 3
6477 SIAH1; siah E3 ubiquitin protein ligase 1
54205 CYCS; cytochrome c, somatic
317 APAF1; apoptotic peptidase activating factor 1
842 CASP9; caspase 9
836 CASP3; caspase 3
84883 AIFM2; apoptosis inducing factor mitochondria associated 2
3486 IGFBP3; insulin like growth factor binding protein 3
3479 IGF1; insulin like growth factor 1
5054 SERPINE1; serpin family E member 1
575 ADGRB1; adhesion G protein-coupled receptor B1
3732 CD82; CD82 molecule
7057 THBS1; thrombospondin 1
5268 SERPINB5; serpin family B member 5
1643 DDB2; damage specific DNA binding protein 2
50484 RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B
6241 RRM2; ribonucleotide reductase regulatory subunit M2
27244 SESN1; sestrin 1
143686 SESN3; sestrin 3
83667 SESN2; sestrin 2
5728 PTEN; phosphatase and tensin homolog
7249 TSC2; TSC complex subunit 2
55240 STEAP3; STEAP3 metalloreductase
64326 COP1; COP1 E3 ubiquitin ligase
25898 RCHY1; ring finger and CHY zinc finger domain containing 1
900 CCNG1; cyclin G1
901 CCNG2; cyclin G2
8493 PPM1D; protein phosphatase, Mg2+/Mn2+ dependent 1D
7161 TP73; tumor protein p73
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K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
K19748 GORAB; RAB6-interacting golgin
K06621 CDKN2A; cyclin-dependent kinase inhibitor 2A
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K10127 MDM4; protein Mdm4
K04451 TP53; tumor protein p53
K27356 PPP1R13L; RelA-associated inhibitor
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K04503 CCND1; G1/S-specific cyclin-D1
K10151 CCND2; G1/S-specific cyclin-D2
K10152 CCND3; G1/S-specific cyclin-D3
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K06626 CCNE; G1/S-specific cyclin-E1
K06626 CCNE; G1/S-specific cyclin-E1
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06644 SFN; stratifin
K10128 RPRM; reprimo, TP53-dependent G2 arrest mediator candidate
K05868 CCNB1; G2/mitotic-specific cyclin-B1
K21770 CCNB2; G2/mitotic-specific cyclin-B2
K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K10129 GTSE1; G-2 and S-phase expressed protein 1
K26543 ZNF385A; zinc finger protein 385A
K04390 TNFRSF6; tumor necrosis factor receptor superfamily member 6
K10130 LRDD; leucine-rich repeats and death domain-containing protein
K04722 TNFRSF10A_B; tumor necrosis factor receptor superfamily member 10A/B
K04722 TNFRSF10A_B; tumor necrosis factor receptor superfamily member 10A/B
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04726 BID; BH3 interacting domain death agonist
K02159 BAX; apoptosis regulator BAX
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K10132 BBC3; Bcl-2-binding component 3
K13773 TP53AIP1; p53-regulated apoptosis-inducing protein 1
K22744 SIVA1; apoptosis regulatory protein Siva
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K02161 BCL2; apoptosis regulator Bcl-2
K10133 TP53I3; tumor protein p53-inducible protein 3 [EC:1.-.-.-]
K10134 EI24; etoposide-induced 2.4 mRNA
K10135 SCOTIN; scotin
K10136 PERP; TP53 apoptosis effector
K10137 ZMAT3; zinc finger, matrin type 3
K04506 SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K22745 AIFM2; apoptosis-inducing factor 2
K10138 IGFBP3; insulin-like growth factor-binding protein 3
K05459 IGF1; insulin-like growth factor 1
K03982 SERPINE1; plasminogen activator inhibitor 1
K04596 ADGRB1; adhesion G protein-coupled receptor B1
K06509 KAI1; CD82 antigen
K16857 THBS1; thrombospondin 1
K10139 SERPINB5; serpin B5
K10140 DDB2; DNA damage-binding protein 2
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K10141 SESN1_3; sestrin 1/3
K10141 SESN1_3; sestrin 1/3
K20394 SESN2; sestrin 2
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K07207 TSC2; tuberous sclerosis 2
K10142 STEAP3; metalloreductase STEAP3 [EC:1.16.1.-]
K10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
K10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]
K10145 CCNG1; cyclin G1
K10146 CCNG2; cyclin G2
K10147 PPM1D; protein phosphatase 1D [EC:3.1.3.16]
K10148 TP73; tumor protein p73
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04218 Cellular senescence [PATH:hsa04218]
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09144 Cellular community - eukaryotes
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09145 Cellular community - prokaryotes
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09142 Cell motility
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09150 Organismal Systems
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09160 Human Diseases
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09161 Cancer: overview
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05200 Pathways in cancer [PATH:hsa05200]
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1630 DCC; DCC netrin 1 receptor
836 CASP3; caspase 3
842 CASP9; caspase 9
26060 APPL1; adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
999 CDH1; cadherin 1
1499 CTNNB1; catenin beta 1
29119 CTNNA3; catenin alpha 3
1495 CTNNA1; catenin alpha 1
1496 CTNNA2; catenin alpha 2
8312 AXIN1; axin 1
8313 AXIN2; axin 2
324 APC; APC regulator of WNT signaling pathway
10297 APC2; APC regulator of WNT signaling pathway 2
2932 GSK3B; glycogen synthase kinase 3 beta
6932 TCF7; transcription factor 7
83439 TCF7L1; transcription factor 7 like 1
6934 TCF7L2; transcription factor 7 like 2
51176 LEF1; lymphoid enhancer binding factor 1
332 BIRC5; baculoviral IAP repeat containing 5
4609 MYC; MYC proto-oncogene, bHLH transcription factor
595 CCND1; cyclin D1
7471 WNT1; Wnt family member 1
7472 WNT2; Wnt family member 2
7482 WNT2B; Wnt family member 2B
7473 WNT3; Wnt family member 3
89780 WNT3A; Wnt family member 3A
54361 WNT4; Wnt family member 4
7474 WNT5A; Wnt family member 5A
81029 WNT5B; Wnt family member 5B
7475 WNT6; Wnt family member 6
7476 WNT7A; Wnt family member 7A
7477 WNT7B; Wnt family member 7B
7478 WNT8A; Wnt family member 8A
7479 WNT8B; Wnt family member 8B
7483 WNT9A; Wnt family member 9A
7484 WNT9B; Wnt family member 9B
7480 WNT10B; Wnt family member 10B
80326 WNT10A; Wnt family member 10A
7481 WNT11; Wnt family member 11
51384 WNT16; Wnt family member 16
8321 FZD1; frizzled class receptor 1
8324 FZD7; frizzled class receptor 7
2535 FZD2; frizzled class receptor 2
7976 FZD3; frizzled class receptor 3
8322 FZD4; frizzled class receptor 4
7855 FZD5; frizzled class receptor 5
8325 FZD8; frizzled class receptor 8
8323 FZD6; frizzled class receptor 6
11211 FZD10; frizzled class receptor 10
8326 FZD9; frizzled class receptor 9
4041 LRP5; LDL receptor related protein 5
4040 LRP6; LDL receptor related protein 6
1857 DVL3; dishevelled segment polarity protein 3
1856 DVL2; dishevelled segment polarity protein 2
1855 DVL1; dishevelled segment polarity protein 1
10023 FRAT1; FRAT regulator of WNT signaling pathway 1
23401 FRAT2; FRAT regulator of WNT signaling pathway 2
2147 F2; coagulation factor II, thrombin
183 AGT; angiotensinogen
2149 F2R; coagulation factor II thrombin receptor
9002 F2RL3; F2R like thrombin or trypsin receptor 3
1902 LPAR1; lysophosphatidic acid receptor 1
9170 LPAR2; lysophosphatidic acid receptor 2
23566 LPAR3; lysophosphatidic acid receptor 3
2846 LPAR4; lysophosphatidic acid receptor 4
57121 LPAR5; lysophosphatidic acid receptor 5
10161 LPAR6; lysophosphatidic acid receptor 6
185 AGTR1; angiotensin II receptor type 1
2768 GNA12; G protein subunit alpha 12
10672 GNA13; G protein subunit alpha 13
23365 ARHGEF12; Rho guanine nucleotide exchange factor 12
9826 ARHGEF11; Rho guanine nucleotide exchange factor 11
9138 ARHGEF1; Rho guanine nucleotide exchange factor 1
57449 PLEKHG5; pleckstrin homology and RhoGEF domain containing G5
387 RHOA; ras homolog family member A
6093 ROCK1; Rho associated coiled-coil containing protein kinase 1
9475 ROCK2; Rho associated coiled-coil containing protein kinase 2
6387 CXCL12; C-X-C motif chemokine ligand 12
7852 CXCR4; C-X-C motif chemokine receptor 4
2770 GNAI1; G protein subunit alpha i1
2773 GNAI3; G protein subunit alpha i3
2771 GNAI2; G protein subunit alpha i2
5731 PTGER1; prostaglandin E receptor 1
5732 PTGER2; prostaglandin E receptor 2
5733 PTGER3; prostaglandin E receptor 3
5734 PTGER4; prostaglandin E receptor 4
2778 GNAS; GNAS complex locus
107 ADCY1; adenylate cyclase 1
108 ADCY2; adenylate cyclase 2
109 ADCY3; adenylate cyclase 3
196883 ADCY4; adenylate cyclase 4
111 ADCY5; adenylate cyclase 5
112 ADCY6; adenylate cyclase 6
113 ADCY7; adenylate cyclase 7
114 ADCY8; adenylate cyclase 8
115 ADCY9; adenylate cyclase 9
5566 PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567 PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568 PRKACG; protein kinase cAMP-activated catalytic subunit gamma
2782 GNB1; G protein subunit beta 1
2783 GNB2; G protein subunit beta 2
2784 GNB3; G protein subunit beta 3
59345 GNB4; G protein subunit beta 4
10681 GNB5; G protein subunit beta 5
54331 GNG2; G protein subunit gamma 2
2785 GNG3; G protein subunit gamma 3
2786 GNG4; G protein subunit gamma 4
2787 GNG5; G protein subunit gamma 5
2788 GNG7; G protein subunit gamma 7
94235 GNG8; G protein subunit gamma 8
2790 GNG10; G protein subunit gamma 10
2791 GNG11; G protein subunit gamma 11
55970 GNG12; G protein subunit gamma 12
51764 GNG13; G protein subunit gamma 13
2792 GNGT1; G protein subunit gamma transducin 1
2793 GNGT2; G protein subunit gamma transducin 2
1284 COL4A2; collagen type IV alpha 2 chain
1286 COL4A4; collagen type IV alpha 4 chain
1288 COL4A6; collagen type IV alpha 6 chain
1282 COL4A1; collagen type IV alpha 1 chain
1287 COL4A5; collagen type IV alpha 5 chain
1285 COL4A3; collagen type IV alpha 3 chain
284217 LAMA1; laminin subunit alpha 1
3908 LAMA2; laminin subunit alpha 2
3909 LAMA3; laminin subunit alpha 3
3911 LAMA5; laminin subunit alpha 5
3910 LAMA4; laminin subunit alpha 4
3912 LAMB1; laminin subunit beta 1
3913 LAMB2; laminin subunit beta 2
3914 LAMB3; laminin subunit beta 3
22798 LAMB4; laminin subunit beta 4
3915 LAMC1; laminin subunit gamma 1
3918 LAMC2; laminin subunit gamma 2
10319 LAMC3; laminin subunit gamma 3
2335 FN1; fibronectin 1
3673 ITGA2; integrin subunit alpha 2
3674 ITGA2B; integrin subunit alpha 2b
3675 ITGA3; integrin subunit alpha 3
3655 ITGA6; integrin subunit alpha 6
3685 ITGAV; integrin subunit alpha V
3688 ITGB1; integrin subunit beta 1
5747 PTK2; protein tyrosine kinase 2
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
5728 PTEN; phosphatase and tensin homolog
4824 NKX3-1; NK3 homeobox 1
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
1147 CHUK; component of inhibitor of nuclear factor kappa B kinase complex
3551 IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517 IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
4792 NFKBIA; NFKB inhibitor alpha
4790 NFKB1; nuclear factor kappa B subunit 1
4791 NFKB2; nuclear factor kappa B subunit 2
5970 RELA; RELA proto-oncogene, NF-kB subunit
5743 PTGS2; prostaglandin-endoperoxide synthase 2
4843 NOS2; nitric oxide synthase 2
596 BCL2; BCL2 apoptosis regulator
329 BIRC2; baculoviral IAP repeat containing 2
330 BIRC3; baculoviral IAP repeat containing 3
331 XIAP; X-linked inhibitor of apoptosis
79444 BIRC7; baculoviral IAP repeat containing 7
598 BCL2L1; BCL2 like 1
7185 TRAF1; TNF receptor associated factor 1
7186 TRAF2; TNF receptor associated factor 2
7187 TRAF3; TNF receptor associated factor 3
9618 TRAF4; TNF receptor associated factor 4
7188 TRAF5; TNF receptor associated factor 5
7189 TRAF6; TNF receptor associated factor 6
2475 MTOR; mechanistic target of rapamycin kinase
6198 RPS6KB1; ribosomal protein S6 kinase B1
6199 RPS6KB2; ribosomal protein S6 kinase B2
572 BAD; BCL2 associated agonist of cell death
2308 FOXO1; forkhead box O1
4193 MDM2; MDM2 proto-oncogene
7157 TP53; tumor protein p53
1027 CDKN1B; cyclin dependent kinase inhibitor 1B
1026 CDKN1A; cyclin dependent kinase inhibitor 1A
613 BCR; BCR activator of RhoGEF and GTPase
25 ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase
1398 CRK; CRK proto-oncogene, adaptor protein
1399 CRKL; CRK like proto-oncogene, adaptor protein
867 CBL; Cbl proto-oncogene
6776 STAT5A; signal transducer and activator of transcription 5A
6777 STAT5B; signal transducer and activator of transcription 5B
5292 PIM1; Pim-1 proto-oncogene, serine/threonine kinase
11040 PIM2; Pim-2 proto-oncogene, serine/threonine kinase
3827 KNG1; kininogen 1
1906 EDN1; endothelin 1
623 BDKRB1; bradykinin receptor B1
624 BDKRB2; bradykinin receptor B2
1909 EDNRA; endothelin receptor type A
1910 EDNRB; endothelin receptor type B
2776 GNAQ; G protein subunit alpha q
2767 GNA11; G protein subunit alpha 11
23236 PLCB1; phospholipase C beta 1
5330 PLCB2; phospholipase C beta 2
5331 PLCB3; phospholipase C beta 3
5332 PLCB4; phospholipase C beta 4
5578 PRKCA; protein kinase C alpha
5579 PRKCB; protein kinase C beta
5582 PRKCG; protein kinase C gamma
3558 IL2; interleukin 2
3562 IL3; interleukin 3
3565 IL4; interleukin 4
3567 IL5; interleukin 5
3569 IL6; interleukin 6
3574 IL7; interleukin 7
3592 IL12A; interleukin 12A
3593 IL12B; interleukin 12B
3596 IL13; interleukin 13
3600 IL15; interleukin 15
51561 IL23A; interleukin 23 subunit alpha
2056 EPO; erythropoietin
3439 IFNA1; interferon alpha 1
3440 IFNA2; interferon alpha 2
3441 IFNA4; interferon alpha 4
3442 IFNA5; interferon alpha 5
3443 IFNA6; interferon alpha 6
3444 IFNA7; interferon alpha 7
3445 IFNA8; interferon alpha 8
3446 IFNA10; interferon alpha 10
3447 IFNA13; interferon alpha 13
3448 IFNA14; interferon alpha 14
3449 IFNA16; interferon alpha 16
3451 IFNA17; interferon alpha 17
3452 IFNA21; interferon alpha 21
3458 IFNG; interferon gamma
3559 IL2RA; interleukin 2 receptor subunit alpha
3560 IL2RB; interleukin 2 receptor subunit beta
3561 IL2RG; interleukin 2 receptor subunit gamma
3563 IL3RA; interleukin 3 receptor subunit alpha
3566 IL4R; interleukin 4 receptor
1439 CSF2RB; colony stimulating factor 2 receptor subunit beta
3568 IL5RA; interleukin 5 receptor subunit alpha
3570 IL6R; interleukin 6 receptor
3572 IL6ST; interleukin 6 cytokine family signal transducer
3575 IL7R; interleukin 7 receptor
3594 IL12RB1; interleukin 12 receptor subunit beta 1
3595 IL12RB2; interleukin 12 receptor subunit beta 2
3597 IL13RA1; interleukin 13 receptor subunit alpha 1
3601 IL15RA; interleukin 15 receptor subunit alpha
149233 IL23R; interleukin 23 receptor
2057 EPOR; erythropoietin receptor
3454 IFNAR1; interferon alpha and beta receptor subunit 1
3455 IFNAR2; interferon alpha and beta receptor subunit 2
3459 IFNGR1; interferon gamma receptor 1
3460 IFNGR2; interferon gamma receptor 2
27436 EML4; EMAP like 4
238 ALK; ALK receptor tyrosine kinase
10125 RASGRP1; RAS guanyl releasing protein 1
10235 RASGRP2; RAS guanyl releasing protein 2
25780 RASGRP3; RAS guanyl releasing protein 3
115727 RASGRP4; RAS guanyl releasing protein 4
3716 JAK1; Janus kinase 1
3717 JAK2; Janus kinase 2
3718 JAK3; Janus kinase 3
6774 STAT3; signal transducer and activator of transcription 3
6772 STAT1; signal transducer and activator of transcription 1
6773 STAT2; signal transducer and activator of transcription 2
6775 STAT4; signal transducer and activator of transcription 4
6778 STAT6; signal transducer and activator of transcription 6
7422 VEGFA; vascular endothelial growth factor A
7423 VEGFB; vascular endothelial growth factor B
5228 PGF; placental growth factor
7424 VEGFC; vascular endothelial growth factor C
2277 VEGFD; vascular endothelial growth factor D
7039 TGFA; transforming growth factor alpha
1950 EGF; epidermal growth factor
1956 EGFR; epidermal growth factor receptor
2064 ERBB2; erb-b2 receptor tyrosine kinase 2
5154 PDGFA; platelet derived growth factor subunit A
5155 PDGFB; platelet derived growth factor subunit B
5156 PDGFRA; platelet derived growth factor receptor alpha
5159 PDGFRB; platelet derived growth factor receptor beta
3479 IGF1; insulin like growth factor 1
3481 IGF2; insulin like growth factor 2
3480 IGF1R; insulin like growth factor 1 receptor
4254 KITLG; KIT ligand
3815 KIT; KIT proto-oncogene, receptor tyrosine kinase
2323 FLT3LG; fms related receptor tyrosine kinase 3 ligand
2322 FLT3; fms related receptor tyrosine kinase 3
3082 HGF; hepatocyte growth factor
4233 MET; MET proto-oncogene, receptor tyrosine kinase
2246 FGF1; fibroblast growth factor 1
2247 FGF2; fibroblast growth factor 2
2248 FGF3; fibroblast growth factor 3
2249 FGF4; fibroblast growth factor 4
8822 FGF17; fibroblast growth factor 17
2251 FGF6; fibroblast growth factor 6
2252 FGF7; fibroblast growth factor 7
2253 FGF8; fibroblast growth factor 8
2254 FGF9; fibroblast growth factor 9
2255 FGF10; fibroblast growth factor 10
8823 FGF16; fibroblast growth factor 16
2250 FGF5; fibroblast growth factor 5
8817 FGF18; fibroblast growth factor 18
26281 FGF20; fibroblast growth factor 20
27006 FGF22; fibroblast growth factor 22
9965 FGF19; fibroblast growth factor 19
26291 FGF21; fibroblast growth factor 21
8074 FGF23; fibroblast growth factor 23
2260 FGFR1; fibroblast growth factor receptor 1
2263 FGFR2; fibroblast growth factor receptor 2
2261 FGFR3; fibroblast growth factor receptor 3
2264 FGFR4; fibroblast growth factor receptor 4
2885 GRB2; growth factor receptor bound protein 2
6654 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265 HRAS; HRas proto-oncogene, GTPase
3845 KRAS; KRAS proto-oncogene, GTPase
4893 NRAS; NRAS proto-oncogene, GTPase
369 ARAF; A-Raf proto-oncogene, serine/threonine kinase
673 BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604 MAP2K1; mitogen-activated protein kinase kinase 1
5605 MAP2K2; mitogen-activated protein kinase kinase 2
5594 MAPK1; mitogen-activated protein kinase 1
5595 MAPK3; mitogen-activated protein kinase 3
3725 JUN; Jun proto-oncogene, AP-1 transcription factor subunit
2353 FOS; Fos proto-oncogene, AP-1 transcription factor subunit
2113 ETS1; ETS proto-oncogene 1, transcription factor
4312 MMP1; matrix metallopeptidase 1
4313 MMP2; matrix metallopeptidase 2
4318 MMP9; matrix metallopeptidase 9
3576 CXCL8; C-X-C motif chemokine ligand 8
1019 CDK4; cyclin dependent kinase 4
9252 RPS6KA5; ribosomal protein S6 kinase A5
5979 RET; ret proto-oncogene
8030 CCDC6; coiled-coil domain containing 6
8031 NCOA4; nuclear receptor coactivator 4
4914 NTRK1; neurotrophic receptor tyrosine kinase 1
7170 TPM3; tropomyosin 3
7175 TPR; translocated promoter region, nuclear basket protein
10342 TFG; trafficking from ER to golgi regulator
11186 RASSF1; Ras association domain family member 1
83593 RASSF5; Ras association domain family member 5
6789 STK4; serine/threonine kinase 4
1612 DAPK1; death associated protein kinase 1
1613 DAPK3; death associated protein kinase 3
23604 DAPK2; death associated protein kinase 2
5335 PLCG1; phospholipase C gamma 1
5336 PLCG2; phospholipase C gamma 2
2002 ELK1; ETS transcription factor ELK1
810 CALML3; calmodulin like 3
805 CALM2; calmodulin 2
808 CALM3; calmodulin 3
801 CALM1; calmodulin 1
163688 CALML6; calmodulin like 6
51806 CALML5; calmodulin like 5
91860 CALML4; calmodulin like 4
815 CAMK2A; calcium/calmodulin dependent protein kinase II alpha
817 CAMK2D; calcium/calmodulin dependent protein kinase II delta
816 CAMK2B; calcium/calmodulin dependent protein kinase II beta
818 CAMK2G; calcium/calmodulin dependent protein kinase II gamma
5900 RALGDS; ral guanine nucleotide dissociation stimulator
5898 RALA; RAS like proto-oncogene A
5899 RALB; RAS like proto-oncogene B
10928 RALBP1; ralA binding protein 1
998 CDC42; cell division cycle 42
5879 RAC1; Rac family small GTPase 1
5880 RAC2; Rac family small GTPase 2
5881 RAC3; Rac family small GTPase 3
5337 PLD1; phospholipase D1
5338 PLD2; phospholipase D2
5599 MAPK8; mitogen-activated protein kinase 8
5602 MAPK10; mitogen-activated protein kinase 10
5601 MAPK9; mitogen-activated protein kinase 9
7849 PAX8; paired box 8
5468 PPARG; peroxisome proliferator activated receptor gamma
6256 RXRA; retinoid X receptor alpha
6257 RXRB; retinoid X receptor beta
6258 RXRG; retinoid X receptor gamma
5915 RARB; retinoic acid receptor beta
2099 ESR1; estrogen receptor 1
2100 ESR2; estrogen receptor 2
8648 NCOA1; nuclear receptor coactivator 1
8202 NCOA3; nuclear receptor coactivator 3
6667 SP1; Sp1 transcription factor
5467 PPARD; peroxisome proliferator activated receptor delta
3728 JUP; junction plakoglobin
7704 ZBTB16; zinc finger and BTB domain containing 16
5914 RARA; retinoic acid receptor alpha
890 CCNA2; cyclin A2
8900 CCNA1; cyclin A1
5371 PML; PML nuclear body scaffold
861 RUNX1; RUNX family transcription factor 1
862 RUNX1T1; RUNX1 partner transcriptional co-repressor 1
6688 SPI1; Spi-1 proto-oncogene
1050 CEBPA; CCAAT enhancer binding protein alpha
1438 CSF2RA; colony stimulating factor 2 receptor subunit alpha
1441 CSF3R; colony stimulating factor 3 receptor
1436 CSF1R; colony stimulating factor 1 receptor
1029 CDKN2A; cyclin dependent kinase inhibitor 2A
1869 E2F1; E2F transcription factor 1
1870 E2F2; E2F transcription factor 2
1871 E2F3; E2F transcription factor 3
4149 MAX; MYC associated factor X
7709 ZBTB17; zinc finger and BTB domain containing 17
1030 CDKN2B; cyclin dependent kinase inhibitor 2B
1021 CDK6; cyclin dependent kinase 6
894 CCND2; cyclin D2
896 CCND3; cyclin D3
1163 CKS1B; CDC28 protein kinase regulatory subunit 1B
1164 CKS2; CDC28 protein kinase regulatory subunit 2
6500 SKP1; S-phase kinase associated protein 1
8454 CUL1; cullin 1
9978 RBX1; ring-box 1
6502 SKP2; S-phase kinase associated protein 2
1017 CDK2; cyclin dependent kinase 2
898 CCNE1; cyclin E1
9134 CCNE2; cyclin E2
5925 RB1; RB transcriptional corepressor 1
1647 GADD45A; growth arrest and DNA damage inducible alpha
4616 GADD45B; growth arrest and DNA damage inducible beta
10912 GADD45G; growth arrest and DNA damage inducible gamma
581 BAX; BCL2 associated X, apoptosis regulator
578 BAK1; BCL2 antagonist/killer 1
1643 DDB2; damage specific DNA binding protein 2
51426 POLK; DNA polymerase kappa
7015 TERT; telomerase reverse transcriptase
7012 TERC; telomerase RNA component
4286 MITF; melanocyte inducing transcription factor
7040 TGFB1; transforming growth factor beta 1
7042 TGFB2; transforming growth factor beta 2
7043 TGFB3; transforming growth factor beta 3
7046 TGFBR1; transforming growth factor beta receptor 1
7048 TGFBR2; transforming growth factor beta receptor 2
4087 SMAD2; SMAD family member 2
4088 SMAD3; SMAD family member 3
4089 SMAD4; SMAD family member 4
2122 MECOM; MDS1 and EVI1 complex locus
1487 CTBP1; C-terminal binding protein 1
1488 CTBP2; C-terminal binding protein 2
3065 HDAC1; histone deacetylase 1
3066 HDAC2; histone deacetylase 2
4292 MLH1; mutL homolog 1
4436 MSH2; mutS homolog 2
4437 MSH3; mutS homolog 3
2956 MSH6; mutS homolog 6
675 BRCA2; BRCA2 DNA repair associated
5888 RAD51; RAD51 recombinase
356 FASLG; Fas ligand
355 FAS; Fas cell surface death receptor
8772 FADD; Fas associated via death domain
841 CASP8; caspase 8
637 BID; BH3 interacting domain death agonist
5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
27113 BBC3; BCL2 binding component 3
10018 BCL2L11; BCL2 like 11
54205 CYCS; cytochrome c, somatic
317 APAF1; apoptotic peptidase activating factor 1
840 CASP7; caspase 7
9817 KEAP1; kelch like ECH associated protein 1
4780 NFE2L2; NFE2 like bZIP transcription factor 2
3162 HMOX1; heme oxygenase 1
1728 NQO1; NAD(P)H quinone dehydrogenase 1
221357 GSTA5; glutathione S-transferase alpha 5
2939 GSTA2; glutathione S-transferase alpha 2
2941 GSTA4; glutathione S-transferase alpha 4
119391 GSTO2; glutathione S-transferase omega 2
2948 GSTM4; glutathione S-transferase mu 4
2953 GSTT2; glutathione S-transferase theta 2 (gene/pseudogene)
2952 GSTT1; glutathione S-transferase theta 1
2947 GSTM3; glutathione S-transferase mu 3
4257 MGST1; microsomal glutathione S-transferase 1
4259 MGST3; microsomal glutathione S-transferase 3
2944 GSTM1; glutathione S-transferase mu 1
2949 GSTM5; glutathione S-transferase mu 5
4258 MGST2; microsomal glutathione S-transferase 2
2938 GSTA1; glutathione S-transferase alpha 1
2946 GSTM2; glutathione S-transferase mu 2
2940 GSTA3; glutathione S-transferase alpha 3
9446 GSTO1; glutathione S-transferase omega 1
653689 GSTT2B; glutathione S-transferase theta 2B
2950 GSTP1; glutathione S-transferase pi 1
7296 TXNRD1; thioredoxin reductase 1
114112 TXNRD3; thioredoxin reductase 3
10587 TXNRD2; thioredoxin reductase 2
7428 VHL; von Hippel-Lindau tumor suppressor
6921 ELOC; elongin C
6923 ELOB; elongin B
8453 CUL2; cullin 2
54583 EGLN1; egl-9 family hypoxia inducible factor 1
112399 EGLN3; egl-9 family hypoxia inducible factor 3
112398 EGLN2; egl-9 family hypoxia inducible factor 2
2271 FH; fumarate hydratase
3091 HIF1A; hypoxia inducible factor 1 subunit alpha
2034 EPAS1; endothelial PAS domain protein 1
405 ARNT; aryl hydrocarbon receptor nuclear translocator
9915 ARNT2; aryl hydrocarbon receptor nuclear translocator 2
1387 CREBBP; CREB binding protein
2033 EP300; E1A binding protein p300
6513 SLC2A1; solute carrier family 2 member 1
182 JAG1; jagged canonical Notch ligand 1
3714 JAG2; jagged canonical Notch ligand 2
10683 DLL3; delta like canonical Notch ligand 3
28514 DLL1; delta like canonical Notch ligand 1
54567 DLL4; delta like canonical Notch ligand 4
4851 NOTCH1; notch receptor 1
4853 NOTCH2; notch receptor 2
4854 NOTCH3; notch receptor 3
4855 NOTCH4; notch receptor 4
3280 HES1; hes family bHLH transcription factor 1
388585 HES5; hes family bHLH transcription factor 5
26508 HEYL; hes related family bHLH transcription factor with YRPW motif like
23462 HEY1; hes related family bHLH transcription factor with YRPW motif 1
23493 HEY2; hes related family bHLH transcription factor with YRPW motif 2
2324 FLT4; fms related receptor tyrosine kinase 4
6469 SHH; sonic hedgehog signaling molecule
5727 PTCH1; patched 1
6608 SMO; smoothened, frizzled class receptor
374654 KIF7; kinesin family member 7
51684 SUFU; SUFU negative regulator of hedgehog signaling
2735 GLI1; GLI family zinc finger 1
2736 GLI2; GLI family zinc finger 2
2737 GLI3; GLI family zinc finger 3
650 BMP2; bone morphogenetic protein 2
652 BMP4; bone morphogenetic protein 4
64399 HHIP; hedgehog interacting protein
8643 PTCH2; patched 2
367 AR; androgen receptor
3320 HSP90AA1; heat shock protein 90 alpha family class A member 1
3326 HSP90AB1; heat shock protein 90 alpha family class B member 1
7184 HSP90B1; heat shock protein 90 beta family member 1
354 KLK3; kallikrein related peptidase 3
|
K06765 DCC; deleted in colorectal carcinoma
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K08733 APPL1; DCC-interacting protein 13 alpha
K05689 CDH1; cadherin 1, type 1, E-cadherin
K02105 CTNNB1; catenin beta 1
K05691 CTNNA; catenin alpha
K05691 CTNNA; catenin alpha
K05691 CTNNA; catenin alpha
K02157 AXIN1; axin 1
K04385 AXIN2; axin 2
K02085 APC; adenomatosis polyposis coli protein
K02085 APC; adenomatosis polyposis coli protein
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02620 TCF7; transcription factor 7
K04490 TCF7L1; transcription factor 7-like 1
K04491 TCF7L2; transcription factor 7-like 2
K04492 LEF1; lymphoid enhancer-binding factor 1
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K04377 MYC; Myc proto-oncogene protein
K04503 CCND1; G1/S-specific cyclin-D1
K03209 WNT1; wingless-type MMTV integration site family, member 1
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00408 WNT4; wingless-type MMTV integration site family, member 4
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00445 WNT6; wingless-type MMTV integration site family, member 6
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00714 WNT8; wingless-type MMTV integration site family, member 8
K00714 WNT8; wingless-type MMTV integration site family, member 8
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01384 WNT11; wingless-type MMTV integration site family, member 11
K01558 WNT16; wingless-type MMTV integration site family, member 16
K02432 FZD1_7; frizzled 1/7
K02432 FZD1_7; frizzled 1/7
K02235 FZD2; frizzled 2
K02329 FZD3; frizzled 3
K02354 FZD4; frizzled 4
K02375 FZD5_8; frizzled 5/8
K02375 FZD5_8; frizzled 5/8
K02376 FZD6; frizzled 6
K02842 FZD9_10; frizzled 9/10
K02842 FZD9_10; frizzled 9/10
K03068 LRP5_6; low density lipoprotein receptor-related protein 5/6
K03068 LRP5_6; low density lipoprotein receptor-related protein 5/6
K02353 DVL; segment polarity protein dishevelled
K02353 DVL; segment polarity protein dishevelled
K02353 DVL; segment polarity protein dishevelled
K03069 FRAT1; frequently rearranged in advanced T-cell lymphomas 1
K03096 FRAT2; frequently rearranged in advanced T-cell lymphomas 2
K01313 F2; coagulation factor II (thrombin) [EC:3.4.21.5]
K09821 AGT; angiotensinogen
K03914 F2R; coagulation factor II (thrombin) receptor
K04236 F2RL3; coagulation factor II (thrombin) receptor-like 3
K04289 LPAR1; lysophosphatidic acid receptor 1
K04291 LPAR2; lysophosphatidic acid receptor 2
K04294 LPAR3; lysophosphatidic acid receptor 3
K04275 LPAR4; lysophosphatidic acid receptor 4
K08390 LPAR5; lysophosphatidic acid receptor 5
K04273 LPAR6; lysophosphatidic acid receptor 6
K04166 AGTR1; angiotensin II receptor type 1
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
K07532 ARHGEF12; Rho guanine nucleotide exchange factor 12
K12331 ARHGEF11; Rho guanine nucleotide exchange factor 11
K12330 ARHGEF1; Rho guanine nucleotide exchange factor 1
K19464 PLEKHG5; pleckstrin homology domain-containing family G member 5
K04513 RHOA; Ras homolog gene family, member A
K04514 ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
K17388 ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
K10031 CXCL12; C-X-C motif chemokine 12
K04189 CXCR4; C-X-C chemokine receptor type 4
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04258 PTGER1; prostaglandin E receptor 1
K04259 PTGER2; prostaglandin E receptor 2
K04260 PTGER3; prostaglandin E receptor 3
K04261 PTGER4; prostaglandin E receptor 4
K04632 GNAS; guanine nucleotide-binding protein G(s) subunit alpha
K08041 ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042 ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08043 ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
K08044 ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045 ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046 ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047 ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048 ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049 ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04536 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
K04537 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
K07825 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
K04538 GNB4; guanine nucleotide-binding protein subunit beta-4
K04539 GNB5; guanine nucleotide-binding protein subunit beta-5
K07826 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
K04540 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
K04541 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
K04542 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
K04543 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
K04544 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
K04545 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
K04546 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
K04347 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K04547 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
K04548 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
K04549 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K06237 COL4A; collagen type IV alpha
K05637 LAMA1_2; laminin, alpha 1/2
K05637 LAMA1_2; laminin, alpha 1/2
K06240 LAMA3_5; laminin, alpha 3/5
K06240 LAMA3_5; laminin, alpha 3/5
K06241 LAMA4; laminin, alpha 4
K05636 LAMB1; laminin, beta 1
K06243 LAMB2; laminin, beta 2
K06244 LAMB3; laminin, beta 3
K06245 LAMB4; laminin, beta 4
K05635 LAMC1; laminin, gamma 1
K06246 LAMC2; laminin, gamma 2
K06247 LAMC3; laminin, gamma 3
K05717 FN1; fibronectin 1
K06481 ITGA2; integrin alpha 2
K06476 ITGA2B; integrin alpha 2B
K06482 ITGA3; integrin alpha 3
K06485 ITGA6; integrin alpha 6
K06487 ITGAV; integrin alpha V
K05719 ITGB1; integrin beta 1
K05725 PTK2; focal adhesion kinase 1 [EC:2.7.10.2]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K09348 NKX3-1; homeobox protein Nkx-3.1
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04735 RELA; transcription factor p65
K11987 PTGS2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K13241 NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
K02161 BCL2; apoptosis regulator Bcl-2
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K03172 TRAF1; TNF receptor-associated factor 1
K03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K03174 TRAF3; TNF receptor-associated factor 3
K09848 TRAF4; TNF receptor-associated factor 4
K09849 TRAF5; TNF receptor-associated factor 5
K03175 TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K02158 BAD; Bcl-2-antagonist of cell death
K07201 FOXO1; forkhead box protein O1
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K04451 TP53; tumor protein p53
K06624 CDKN1B; cyclin-dependent kinase inhibitor 1B
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K08878 BCR1; breakpoint cluster region protein [EC:2.7.11.1]
K06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K04438 CRK; C-crk adapter molecule crk
K04438 CRK; C-crk adapter molecule crk
K04707 CBL; E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]
K11223 STAT5A; signal transducer and activator of transcription 5A
K11224 STAT5B; signal transducer and activator of transcription 5B
K04702 PIM1; proto-oncogene serine/threonine-protein kinase Pim-1 [EC:2.7.11.1]
K08806 PIM2; proto-oncogene serine/threonine-protein kinase Pim-2 [EC:2.7.11.1]
K03898 KNG; kininogen
K16366 EDN1; endothelin-1
K03915 BDKRB1; bradykinin receptor B1
K03916 BDKRB2; bradykinin receptor B2
K04197 EDNRA; endothelin receptor type A
K04198 EDNRB; endothelin receptor type B
K04634 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
K04635 GNA11; guanine nucleotide-binding protein subunit alpha-11
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
K19663 PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
K05429 IL2; interleukin 2
K04736 IL3; interleukin 3
K05430 IL4; interleukin 4
K05428 IL5; interleukin 5
K05405 IL6; interleukin 6
K05431 IL7; interleukin 7
K05406 IL12A; interleukin 12A
K05425 IL12B; interleukin 12B
K05435 IL13; interleukin 13
K05433 IL15; interleukin 15
K05426 IL23A; interleukin 23 subunit alpha
K05437 EPO; erythropoietin
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K05414 IFNA; interferon alpha
K04687 IFNG; interferon gamma
K05068 IL2RA; interleukin 2 receptor alpha
K05069 IL2RB; interleukin 2 receptor beta
K05070 IL2RG; interleukin 2 receptor gamma
K04737 IL3RA; interleukin 3 receptor alpha
K05071 IL4R; interleukin 4 receptor
K04738 CSF2RB; cytokine receptor common subunit beta
K05067 IL5RA; interleukin 5 receptor alpha
K05055 IL6R; interleukin 6 receptor
K05060 IL6ST; interleukin 6 signal transducer
K05072 IL7R; interleukin 7 receptor
K05063 IL12RB1; interleukin 12 receptor beta-1
K05064 IL12RB2; interleukin 12 receptor beta-2
K05076 IL13RA1; interleukin 13 receptor alpha-1
K05074 IL15RA; interleukin 15 receptor alpha
K05065 IL23R; interleukin 23 receptor
K05079 EPOR; erythropoietin receptor
K05130 IFNAR1; interferon receptor 1
K05131 IFNAR2; interferon receptor 2
K05132 IFNGR1; interferon gamma receptor 1
K05133 IFNGR2; interferon gamma receptor 2
K15420 EML4; echinoderm microtubule-associated protein-like 4
K05119 ALK; anaplastic lymphoma kinase [EC:2.7.10.1]
K04350 RASGRP1; RAS guanyl-releasing protein 1
K12361 RASGRP2; RAS guanyl-releasing protein 2
K12362 RASGRP3; RAS guanyl-releasing protein 3
K12363 RASGRP4; RAS guanyl-releasing protein 4
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K04447 JAK2; Janus kinase 2 [EC:2.7.10.2]
K11218 JAK3; Janus kinase 3 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
K11220 STAT1; signal transducer and activator of transcription 1
K11221 STAT2; signal transducer and activator of transcription 2
K11222 STAT4; signal transducer and activator of transcription 4
K11225 STAT6; signal transducer and activator of transcription 6
K05448 VEGFA; vascular endothelial growth factor A
K16858 VEGFB; vascular endothelial growth factor B
K16859 PGF; placenta growth factor
K05449 VEGFC_D; vascular endothelial growth factor C/D
K05449 VEGFC_D; vascular endothelial growth factor C/D
K08774 TGFA; transforming growth factor, alpha
K04357 EGF; epidermal growth factor
K04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]
K05083 ERBB2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K04359 PDGFA; platelet-derived growth factor subunit A
K17386 PDGFB; platelet-derived growth factor subunit B
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05459 IGF1; insulin-like growth factor 1
K13769 IGF2; insulin-like growth factor 2
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K05461 KITLG; KIT ligand
K05091 KIT; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05454 FLT3LG; fms-related tyrosine kinase 3 ligand
K05092 FLT3; fms-related tyrosine kinase 3 [EC:2.7.10.1]
K05460 HGF; hepatocyte growth factor
K05099 MET; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K18496 FGF1; fibroblast growth factor 1
K18497 FGF2; fibroblast growth factor 2
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K04358 FGF; fibroblast growth factor
K22603 FGF19; fibroblast growth factor 19
K22429 FGF21; fibroblast growth factor 21
K22428 FGF23; fibroblast growth factor 23
K04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094 FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
K05095 FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-bound protein 2
K03099 SOS; son of sevenless
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K08845 ARAF; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04448 JUN; transcription factor AP-1
K04379 FOS; proto-oncogene protein c-fos
K02678 ETS1; C-ets-1
K01388 MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K01398 MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
K01403 MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
K10030 IL8; interleukin 8
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K04445 RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
K05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
K09288 CCDC6; coiled-coil domain-containing protein 6
K09289 NCOA4; nuclear receptor coactivator 4
K03176 NTRK1; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K09290 TPM3; tropomyosin 3
K09291 TPR; nucleoprotein TPR
K09292 TFG; protein TFG
K09850 RASSF1; Ras association domain-containing protein 1
K08015 RASSF5; Ras association domain-containing protein 5
K04411 STK4; serine/threonine kinase 4
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K04375 ELK1; ETS domain-containing protein Elk-1
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K02183 CALM; calmodulin
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K08732 RALGDS; ral guanine nucleotide dissociation stimulator
K07834 RALA; Ras-related protein Ral-A
K07835 RALB; Ras-related protein Ral-B
K08773 RALBP1; RalA-binding protein 1
K04393 CDC42; cell division control protein 42
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K09293 PAX8; paired box protein 8
K08530 NR1C3; peroxisome proliferator-activated receptor gamma
K08524 RXRA; retinoid X receptor alpha
K08525 RXRB; retinoid X receptor beta
K08526 RXRG; retinoid X receptor gamma
K08528 RARB; retinoic acid receptor beta
K08550 ESR1; estrogen receptor alpha
K08551 ESR2; estrogen receptor beta
K09101 NCOA1; nuclear receptor coactivator 1 [EC:2.3.1.48]
K11256 NCOA3; nuclear receptor coactivator 3 [EC:2.3.1.48]
K04684 SP1; transcription factor Sp1
K04504 NR1C2; peroxisome proliferator-activated receptor delta
K10056 JUP; junction plakoglobin
K10055 ZBTB16; zinc finger and BTB domain-containing protein 16
K08527 RARA; retinoic acid receptor alpha
K06627 CCNA; cyclin-A
K06627 CCNA; cyclin-A
K10054 PML; E3 SUMO-protein ligase PML [EC:2.3.2.-]
K08367 RUNX1; runt-related transcription factor 1
K10053 RUNX1T1; CBFA2/RNUX1 translocation partner 1
K09438 SPI1; transcription factor PU.1
K09055 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
K05066 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor alpha
K05061 CSF3R; granulocyte colony-stimulating factor receptor
K05090 CSF1R; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K06621 CDKN2A; cyclin-dependent kinase inhibitor 2A
K17454 E2F1; transcription factor E2F1
K09389 E2F2; transcription factor E2F2
K06620 E2F3; transcription factor E2F3
K04453 MAX; Max protein
K10500 ZBTB17; zinc finger and BTB domain-containing protein 17
K04685 CDKN2B; cyclin-dependent kinase inhibitor 2B
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K10151 CCND2; G1/S-specific cyclin-D2
K10152 CCND3; G1/S-specific cyclin-D3
K02219 CKS1; cyclin-dependent kinase regulatory subunit CKS1
K02219 CKS1; cyclin-dependent kinase regulatory subunit CKS1
K03094 SKP1; S-phase kinase-associated protein 1
K03347 CUL1; cullin 1
K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
K03875 SKP2; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06626 CCNE; G1/S-specific cyclin-E1
K06626 CCNE; G1/S-specific cyclin-E1
K06618 RB1; retinoblastoma-associated protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K02159 BAX; apoptosis regulator BAX
K14021 BAK; Bcl-2 homologous antagonist/killer
K10140 DDB2; DNA damage-binding protein 2
K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
K22183 TERC; telomerase RNA component
K09455 MITF; microphthalmia-associated transcription factor
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04500 SMAD2; mothers against decapentaplegic homolog 2
K23605 SMAD3; mothers against decapentaplegic homolog 3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K04462 MECOM; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367]
K04496 CTBP; C-terminal binding protein [EC:1.1.1.428]
K04496 CTBP; C-terminal binding protein [EC:1.1.1.428]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K08734 MLH1; DNA mismatch repair protein MLH1
K08735 MSH2; DNA mismatch repair protein MSH2
K08736 MSH3; DNA mismatch repair protein MSH3
K08737 MSH6; DNA mismatch repair protein MSH6
K08775 BRCA2; breast cancer 2 susceptibility protein
K04482 RAD51; DNA repair protein RAD51
K04389 TNFSF6; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6; tumor necrosis factor receptor superfamily member 6
K02373 FADD; FAS-associated death domain protein
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04726 BID; BH3 interacting domain death agonist
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K10132 BBC3; Bcl-2-binding component 3
K16341 BCL2L11; Bcl-2-like protein 11
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04397 CASP7; caspase 7 [EC:3.4.22.60]
K10456 KLHL19; kelch-like protein 19
K05638 NFE2L2; nuclear factor erythroid 2-related factor 2
K00510 HMOX1; heme oxygenase 1 [EC:1.14.14.18]
K00355 NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K23790 GSTP; glutathione S-transferase P [EC:2.5.1.18]
K22182 TXNRD; thioredoxin reductase (NADPH) [EC:1.8.1.9]
K22182 TXNRD; thioredoxin reductase (NADPH) [EC:1.8.1.9]
K22182 TXNRD; thioredoxin reductase (NADPH) [EC:1.8.1.9]
K03871 VHL; von Hippel-Lindau disease tumor supressor
K03872 ELOC; elongin-C
K03873 ELOB; elongin-B
K03870 CUL2; cullin 2
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K09592 EGLN; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
K01679 E4.2.1.2B; fumarate hydratase, class II [EC:4.2.1.2]
K08268 HIF1A; hypoxia-inducible factor 1 alpha
K09095 HIF2A; hypoxia-inducible factor 2 alpha
K09097 ARNT; aryl hydrocarbon receptor nuclear translocator
K15589 ARNT2; aryl hydrocarbon receptor nuclear translocator 2
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K07299 SLC2A1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K06052 JAG1; jagged-1
K21635 JAG2; jagged-2
K06051 DLL; delta
K06051 DLL; delta
K06051 DLL; delta
K02599 NOTCH1; Notch 1
K20994 NOTCH2; Notch 2
K20995 NOTCH3; Notch 3
K20996 NOTCH4; Notch 4
K06054 HES1; hairy and enhancer of split 1
K06055 HES5; hairy and enhancer of split 5
K09091 HEY; hairy and enhancer of split related with YRPW motif
K09091 HEY; hairy and enhancer of split related with YRPW motif
K09091 HEY; hairy and enhancer of split related with YRPW motif
K05097 FLT4; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
K11988 SHH; sonic hedgehog
K06225 PTCH1; patched 1
K06226 SMO; smoothened
K18806 KIF7; kinesin family member 7
K06229 SUFU; suppressor of fused
K16797 GLI1; zinc finger protein GLI1
K16798 GLI2; zinc finger protein GLI2
K06230 GLI3; zinc finger protein GLI3
K21283 BMP2; bone morphogenetic protein 2
K04662 BMP4; bone morphogenetic protein 4
K06231 HHIP; hedgehog interacting protein
K11101 PTCH2; patched 2
K08557 AR; androgen receptor
K04079 HSP90A; molecular chaperone HtpG
K04079 HSP90A; molecular chaperone HtpG
K09487 HSP90B; heat shock protein 90kDa beta
K01351 KLK3; semenogelase [EC:3.4.21.77]
|
05202 Transcriptional misregulation in cancer [PATH:hsa05202]
|
05206 MicroRNAs in cancer [PATH:hsa05206]
|
05205 Proteoglycans in cancer [PATH:hsa05205]
|
05204 Chemical carcinogenesis - DNA adducts [PATH:hsa05204]
|
05207 Chemical carcinogenesis - receptor activation [PATH:hsa05207]
|
05208 Chemical carcinogenesis - reactive oxygen species [PATH:hsa05208]
|
05203 Viral carcinogenesis [PATH:hsa05203]
|
6714 SRC; SRC proto-oncogene, non-receptor tyrosine kinase
3265 HRAS; HRas proto-oncogene, GTPase
3845 KRAS; KRAS proto-oncogene, GTPase
4893 NRAS; NRAS proto-oncogene, GTPase
5594 MAPK1; mitogen-activated protein kinase 1
5595 MAPK3; mitogen-activated protein kinase 3
1385 CREB1; cAMP responsive element binding protein 1
1386 ATF2; activating transcription factor 2
468 ATF4; activating transcription factor 4
10488 CREB3; cAMP responsive element binding protein 3
90993 CREB3L1; cAMP responsive element binding protein 3 like 1
64764 CREB3L2; cAMP responsive element binding protein 3 like 2
84699 CREB3L3; cAMP responsive element binding protein 3 like 3
148327 CREB3L4; cAMP responsive element binding protein 3 like 4
9586 CREB5; cAMP responsive element binding protein 5
1388 ATF6B; activating transcription factor 6 beta
1642 DDB1; damage specific DNA binding protein 1
7534 YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
7529 YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
10971 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
7531 YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
7533 YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
7532 YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
3716 JAK1; Janus kinase 1
6774 STAT3; signal transducer and activator of transcription 3
6776 STAT5A; signal transducer and activator of transcription 5A
6777 STAT5B; signal transducer and activator of transcription 5B
836 CASP3; caspase 3
3249 HPN; hepsin
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
5970 RELA; RELA proto-oncogene, NF-kB subunit
5966 REL; REL proto-oncogene, NF-kB subunit
4791 NFKB2; nuclear factor kappa B subunit 2
4790 NFKB1; nuclear factor kappa B subunit 1
7157 TP53; tumor protein p53
898 CCNE1; cyclin E1
9134 CCNE2; cyclin E2
1017 CDK2; cyclin dependent kinase 2
1959 EGR2; early growth response 2
1960 EGR3; early growth response 3
7419 VDAC3; voltage dependent anion channel 3
4055 LTBR; lymphotoxin beta receptor
6672 SP100; SP100 nuclear antigen
3190 HNRNPK; heterogeneous nuclear ribonucleoprotein K
1026 CDKN1A; cyclin dependent kinase inhibitor 1A
1654 DDX3X; DEAD-box helicase 3 X-linked
5610 EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2
5566 PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567 PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568 PRKACG; protein kinase cAMP-activated catalytic subunit gamma
8341 H2BC15; H2B clustered histone 15
8345 H2BC9; H2B clustered histone 9
8342 H2BC14; H2B clustered histone 14
158983 H2BW1; H2B.W histone 1
255626 H2BC1; H2B clustered histone 1
440689 H2BC18; H2B clustered histone 18
8348 H2BC17; H2B clustered histone 17
3018 H2BC3; H2B clustered histone 3
8339 H2BC8; H2B clustered histone 8
8340 H2BC13; H2B clustered histone 13
8347 H2BC4; H2B clustered histone 4
3017 H2BC5; H2B clustered histone 5
8344 H2BC6; H2B clustered histone 6
8346 H2BC10; H2B clustered histone 10
8349 H2BC21; H2B clustered histone 21
8970 H2BC11; H2B clustered histone 11
85236 H2BC12; H2B clustered histone 12
128312 H2BC26; H2B clustered histone 26
8343 H2BC7; H2B clustered histone 7
286436 H2BW2; H2B.W histone 2
102724334 histone H2B type F-S-like
114483833 H2BK1; H2B.K variant histone 1
54145 H2BC12L; H2B clustered histone 12 like
121504 H4C16; H4 histone 16
554313 H4C15; H4 clustered histone 15
8294 H4C9; H4 clustered histone 9
8360 H4C4; H4 clustered histone 4
8361 H4C6; H4 clustered histone 6
8362 H4C12; H4 clustered histone 12
8363 H4C11; H4 clustered histone 11
8364 H4C3; H4 clustered histone 3
8365 H4C8; H4 clustered histone 8
8366 H4C2; H4 clustered histone 2
8367 H4C5; H4 clustered histone 5
8368 H4C13; H4 clustered histone 13
8370 H4C14; H4 clustered histone 14
8359 H4C1; H4 clustered histone 1
8369 H4C7; H4 clustered histone 7
581 BAX; BCL2 associated X, apoptosis regulator
2885 GRB2; growth factor receptor bound protein 2
8717 TRADD; TNFRSF1A associated via death domain
983 CDK1; cyclin dependent kinase 1
387332 TBPL2; TATA-box binding protein like 2
9519 TBPL1; TATA-box binding protein like 1
6908 TBP; TATA-box binding protein
7874 USP7; ubiquitin specific peptidase 7
4193 MDM2; MDM2 proto-oncogene
11317 RBPJL; recombination signal binding protein for immunoglobulin kappa J region like
3516 RBPJ; recombination signal binding protein for immunoglobulin kappa J region
22938 SNW1; SNW domain containing 1
2965 GTF2H1; general transcription factor IIH subunit 1
2966 GTF2H2; general transcription factor IIH subunit 2
730394 GTF2H2C_2; GTF2H2 family member C, copy 2
728340 GTF2H2C; GTF2H2 family member C
2967 GTF2H3; general transcription factor IIH subunit 3
2968 GTF2H4; general transcription factor IIH subunit 4
2960 GTF2E1; general transcription factor IIE subunit 1
2961 GTF2E2; general transcription factor IIE subunit 2
27044 SND1; staphylococcal nuclease and tudor domain containing 1
1387 CREBBP; CREB binding protein
2033 EP300; E1A binding protein p300
2959 GTF2B; general transcription factor IIB
595 CCND1; cyclin D1
894 CCND2; cyclin D2
896 CCND3; cyclin D3
1021 CDK6; cyclin dependent kinase 6
890 CCNA2; cyclin A2
8900 CCNA1; cyclin A1
6502 SKP2; S-phase kinase associated protein 2
28973 MRPS18B; mitochondrial ribosomal protein S18B
7185 TRAF1; TNF receptor associated factor 1
7186 TRAF2; TNF receptor associated factor 2
7187 TRAF3; TNF receptor associated factor 3
7188 TRAF5; TNF receptor associated factor 5
3718 JAK3; Janus kinase 3
4067 LYN; LYN proto-oncogene, Src family tyrosine kinase
6850 SYK; spleen associated tyrosine kinase
9114 ATP6V0D1; ATPase H+ transporting V0 subunit d1
245972 ATP6V0D2; ATPase H+ transporting V0 subunit d2
7337 UBE3A; ubiquitin protein ligase E3A
1739 DLG1; discs large MAGUK scaffold protein 1
23513 SCRIB; scribble planar cell polarity protein
5829 PXN; paxillin
578 BAK1; BCL2 antagonist/killer 1
3661 IRF3; interferon regulatory factor 3
5700 PSMC1; proteasome 26S subunit, ATPase 1
5925 RB1; RB transcriptional corepressor 1
5933 RBL1; RB transcriptional corepressor like 1
5934 RBL2; RB transcriptional corepressor like 2
1027 CDKN1B; cyclin dependent kinase inhibitor 1B
23352 UBR4; ubiquitin protein ligase E3 component n-recognin 4
3725 JUN; Jun proto-oncogene, AP-1 transcription factor subunit
1108 CHD4; chromodomain helicase DNA binding protein 4
3065 HDAC1; histone deacetylase 1
3066 HDAC2; histone deacetylase 2
8841 HDAC3; histone deacetylase 3
9759 HDAC4; histone deacetylase 4
10014 HDAC5; histone deacetylase 5
10013 HDAC6; histone deacetylase 6
51564 HDAC7; histone deacetylase 7
55869 HDAC8; histone deacetylase 8
9734 HDAC9; histone deacetylase 9
83933 HDAC10; histone deacetylase 10
79885 HDAC11; histone deacetylase 11
5315 PKM; pyruvate kinase M1/2
10379 IRF9; interferon regulatory factor 9
9093 DNAJA3; DnaJ heat shock protein family (Hsp40) member A3
8850 KAT2B; lysine acetyltransferase 2B
2648 KAT2A; lysine acetyltransferase 2A
11036 GTF2A1L; general transcription factor IIA subunit 1 like
2957 GTF2A1; general transcription factor IIA subunit 1
2958 GTF2A2; general transcription factor IIA subunit 2
6722 SRF; serum response factor
8517 IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
4792 NFKBIA; NFKB inhibitor alpha
5922 RASA2; RAS p21 protein activator 2
998 CDC42; cell division cycle 42
5879 RAC1; Rac family small GTPase 1
387 RHOA; ras homolog family member A
2934 GSN; gelsolin
85477 SCIN; scinderin
87 ACTN1; actinin alpha 1
81 ACTN4; actinin alpha 4
1019 CDK4; cyclin dependent kinase 4
1029 CDKN2A; cyclin dependent kinase inhibitor 2A
1030 CDKN2B; cyclin dependent kinase inhibitor 2B
1111 CHEK1; checkpoint kinase 1
991 CDC20; cell division cycle 20
8379 MAD1L1; mitotic arrest deficient 1 like 1
55697 VAC14; VAC14 component of PIKFYVE complex
5902 RANBP1; RAN binding protein 1
5423 POLB; DNA polymerase beta
3665 IRF7; interferon regulatory factor 7
3572 IL6ST; interleukin 6 cytokine family signal transducer
1234 CCR5; C-C motif chemokine receptor 5
1237 CCR8; C-C motif chemokine receptor 8
1232 CCR3; C-C motif chemokine receptor 3
1233 CCR4; C-C motif chemokine receptor 4
9261 MAPKAPK2; MAPK activated protein kinase 2
841 CASP8; caspase 8
572 BAD; BCL2 associated agonist of cell death
5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
718 C3; complement C3
3105 HLA-A; major histocompatibility complex, class I, A
3106 HLA-B; major histocompatibility complex, class I, B
3107 HLA-C; major histocompatibility complex, class I, C
3134 HLA-F; major histocompatibility complex, class I, F
3135 HLA-G; major histocompatibility complex, class I, G
3133 HLA-E; major histocompatibility complex, class I, E
|
K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K05870 CREB1; cyclic AMP-responsive element-binding protein 1
K04450 ATF2; cyclic AMP-dependent transcription factor ATF-2
K04374 ATF4; cyclic AMP-dependent transcription factor ATF-4
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09047 CREB5; cyclic AMP-responsive element-binding protein 5
K09049 ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta
K10610 DDB1; DNA damage-binding protein 1
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K06630 YWHAE; 14-3-3 protein epsilon
K16198 YWHAG_H; 14-3-3 protein gamma/eta
K16198 YWHAG_H; 14-3-3 protein gamma/eta
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
K11223 STAT5A; signal transducer and activator of transcription 5A
K11224 STAT5B; signal transducer and activator of transcription 5B
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K08665 HPN; hepsin [EC:3.4.21.106]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K04735 RELA; transcription factor p65
K09254 REL; c-Rel proto-oncogene protein
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04451 TP53; tumor protein p53
K06626 CCNE; G1/S-specific cyclin-E1
K06626 CCNE; G1/S-specific cyclin-E1
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K12496 EGR2; early growth response protein 2
K12497 EGR3; early growth response protein 3
K15041 VDAC3; voltage-dependent anion channel protein 3
K03159 TNFRSF3; lymphotoxin beta receptor TNFR superfamily member 3
K15413 SP100; nuclear body protein Sp100
K12886 HNRNPK; heterogeneous nuclear ribonucleoprotein K
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11252 H2B; histone H2B
K11254 H4; histone H4
K11254 H4; histone H4
K11254 H4; histone H4
K11254 H4; histone H4
K11254 H4; histone H4
K11254 H4; histone H4
K11254 H4; histone H4
K11254 H4; histone H4
K11254 H4; histone H4
K11254 H4; histone H4
K11254 H4; histone H4
K11254 H4; histone H4
K11254 H4; histone H4
K11254 H4; histone H4
K11254 H4; histone H4
K02159 BAX; apoptosis regulator BAX
K04364 GRB2; growth factor receptor-bound protein 2
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K03120 TBP; transcription initiation factor TFIID TATA-box-binding protein
K03120 TBP; transcription initiation factor TFIID TATA-box-binding protein
K03120 TBP; transcription initiation factor TFIID TATA-box-binding protein
K11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K06053 RBPSUH; recombining binding protein suppressor of hairless
K06053 RBPSUH; recombining binding protein suppressor of hairless
K06063 SNW1; SNW domain-containing protein 1
K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
K03136 TFIIE1; transcription initiation factor TFIIE subunit alpha
K03137 TFIIE2; transcription initiation factor TFIIE subunit beta
K15979 SND1; staphylococcal nuclease domain-containing protein 1
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
K03124 TFIIB; transcription initiation factor TFIIB
K04503 CCND1; G1/S-specific cyclin-D1
K10151 CCND2; G1/S-specific cyclin-D2
K10152 CCND3; G1/S-specific cyclin-D3
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K06627 CCNA; cyclin-A
K06627 CCNA; cyclin-A
K03875 SKP2; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K16174 MRPS18B; small subunit ribosomal protein S18b, mitochondrial
K03172 TRAF1; TNF receptor-associated factor 1
K03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K03174 TRAF3; TNF receptor-associated factor 3
K09849 TRAF5; TNF receptor-associated factor 5
K11218 JAK3; Janus kinase 3 [EC:2.7.10.2]
K05854 LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
K05855 SYK; spleen tyrosine kinase [EC:2.7.10.2]
K02146 ATPeV0D; V-type H+-transporting ATPase subunit d
K02146 ATPeV0D; V-type H+-transporting ATPase subunit d
K10587 UBE3A; ubiquitin-protein ligase E3 A [EC:2.3.2.26]
K12076 DLG1; disks large protein 1
K16175 SCRIB; protein scribble
K05760 PXN; paxillin
K14021 BAK; Bcl-2 homologous antagonist/killer
K05411 IRF3; interferon regulatory factor 3
K03062 PSMC1; 26S proteasome regulatory subunit T2
K06618 RB1; retinoblastoma-associated protein
K04681 RBL1; retinoblastoma-like protein 1
K16332 RBL2; retinoblastoma-like protein 2
K06624 CDKN1B; cyclin-dependent kinase inhibitor 1B
K10691 UBR4; E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27]
K04448 JUN; transcription factor AP-1
K11643 CHD4; chromodomain-helicase-DNA-binding protein 4 [EC:5.6.2.-]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K11404 HDAC3; histone deacetylase 3 [EC:3.5.1.98]
K11406 HDAC4_5; histone deacetylase 4/5 [EC:3.5.1.98]
K11406 HDAC4_5; histone deacetylase 4/5 [EC:3.5.1.98]
K11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]
K11408 HDAC7; histone deacetylase 7 [EC:3.5.1.98]
K11405 HDAC8; histone deacetylase 8 [EC:3.5.1.98]
K11409 HDAC9; histone deacetylase 9 [EC:3.5.1.98]
K18671 HDAC10; histone deacetylase 10 [EC:3.5.1.98]
K11418 HDAC11; histone deacetylase 11 [EC:3.5.1.98]
K00873 PK; pyruvate kinase [EC:2.7.1.40]
K04693 IRF9; interferon regulatory factor 9
K09504 DNAJA3; DnaJ homolog subfamily A member 3
K06062 PCAF; histone acetyltransferase [EC:2.3.1.48]
K06062 PCAF; histone acetyltransferase [EC:2.3.1.48]
K03122 TFIIA1; transcription initiation factor TFIIA large subunit
K03122 TFIIA1; transcription initiation factor TFIIA large subunit
K03123 TFIIA2; transcription initiation factor TFIIA small subunit
K04378 SRF; serum response factor
K07210 IKBKG; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K08053 RASA2; Ras GTPase-activating protein 2
K04393 CDC42; cell division control protein 42
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K04513 RHOA; Ras homolog gene family, member A
K05768 GSN; gelsolin
K05768 GSN; gelsolin
K05699 ACTN1_4; actinin alpha 1/4
K05699 ACTN1_4; actinin alpha 1/4
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K06621 CDKN2A; cyclin-dependent kinase inhibitor 2A
K04685 CDKN2B; cyclin-dependent kinase inhibitor 2B
K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
K03363 CDC20; cell division cycle 20, cofactor of APC complex
K06679 MAD1; mitotic spindle assembly checkpoint protein MAD1
K15305 VAC14; vacuole morphology and inheritance protein 14
K15306 RANBP1; Ran-binding protein 1
K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
K09447 IRF7; interferon regulatory factor 7
K05060 IL6ST; interleukin 6 signal transducer
K04180 CCR5; C-C chemokine receptor type 5
K04183 CCR8; C-C chemokine receptor type 8
K04178 CCR3; C-C chemokine receptor type 3
K04179 CCR4; C-C chemokine receptor type 4
K04443 MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K02158 BAD; Bcl-2-antagonist of cell death
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K03990 C3; complement component 3
K06751 MHC1; MHC class I antigen
K06751 MHC1; MHC class I antigen
K06751 MHC1; MHC class I antigen
K06751 MHC1; MHC class I antigen
K06751 MHC1; MHC class I antigen
K06751 MHC1; MHC class I antigen
|
05230 Central carbon metabolism in cancer [PATH:hsa05230]
|
05231 Choline metabolism in cancer [PATH:hsa05231]
|
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer [PATH:hsa05235]
|
|
|
09162 Cancer: specific types
|
05210 Colorectal cancer [PATH:hsa05210]
|
2932 GSK3B; glycogen synthase kinase 3 beta
8312 AXIN1; axin 1
8313 AXIN2; axin 2
1499 CTNNB1; catenin beta 1
324 APC; APC regulator of WNT signaling pathway
10297 APC2; APC regulator of WNT signaling pathway 2
6932 TCF7; transcription factor 7
83439 TCF7L1; transcription factor 7 like 1
6934 TCF7L2; transcription factor 7 like 2
51176 LEF1; lymphoid enhancer binding factor 1
332 BIRC5; baculoviral IAP repeat containing 5
4609 MYC; MYC proto-oncogene, bHLH transcription factor
595 CCND1; cyclin D1
3845 KRAS; KRAS proto-oncogene, GTPase
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
572 BAD; BCL2 associated agonist of cell death
842 CASP9; caspase 9
369 ARAF; A-Raf proto-oncogene, serine/threonine kinase
673 BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604 MAP2K1; mitogen-activated protein kinase kinase 1
5605 MAP2K2; mitogen-activated protein kinase kinase 2
5594 MAPK1; mitogen-activated protein kinase 1
5595 MAPK3; mitogen-activated protein kinase 3
3725 JUN; Jun proto-oncogene, AP-1 transcription factor subunit
2353 FOS; Fos proto-oncogene, AP-1 transcription factor subunit
5900 RALGDS; ral guanine nucleotide dissociation stimulator
5898 RALA; RAS like proto-oncogene A
5899 RALB; RAS like proto-oncogene B
5879 RAC1; Rac family small GTPase 1
5880 RAC2; Rac family small GTPase 2
5881 RAC3; Rac family small GTPase 3
387 RHOA; ras homolog family member A
5599 MAPK8; mitogen-activated protein kinase 8
5602 MAPK10; mitogen-activated protein kinase 10
5601 MAPK9; mitogen-activated protein kinase 9
1630 DCC; DCC netrin 1 receptor
836 CASP3; caspase 3
26060 APPL1; adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
7040 TGFB1; transforming growth factor beta 1
7042 TGFB2; transforming growth factor beta 2
7043 TGFB3; transforming growth factor beta 3
7046 TGFBR1; transforming growth factor beta receptor 1
7048 TGFBR2; transforming growth factor beta receptor 2
4087 SMAD2; SMAD family member 2
4088 SMAD3; SMAD family member 3
4089 SMAD4; SMAD family member 4
4292 MLH1; mutL homolog 1
4436 MSH2; mutS homolog 2
4437 MSH3; mutS homolog 3
2956 MSH6; mutS homolog 6
581 BAX; BCL2 associated X, apoptosis regulator
5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
10018 BCL2L11; BCL2 like 11
27113 BBC3; BCL2 binding component 3
596 BCL2; BCL2 apoptosis regulator
54205 CYCS; cytochrome c, somatic
7157 TP53; tumor protein p53
1026 CDKN1A; cyclin dependent kinase inhibitor 1A
1647 GADD45A; growth arrest and DNA damage inducible alpha
4616 GADD45B; growth arrest and DNA damage inducible beta
10912 GADD45G; growth arrest and DNA damage inducible gamma
578 BAK1; BCL2 antagonist/killer 1
1643 DDB2; damage specific DNA binding protein 2
51426 POLK; DNA polymerase kappa
1950 EGF; epidermal growth factor
7039 TGFA; transforming growth factor alpha
2069 EREG; epiregulin
374 AREG; amphiregulin
1956 EGFR; epidermal growth factor receptor
2885 GRB2; growth factor receptor bound protein 2
6654 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265 HRAS; HRas proto-oncogene, GTPase
4893 NRAS; NRAS proto-oncogene, GTPase
2475 MTOR; mechanistic target of rapamycin kinase
6198 RPS6KB1; ribosomal protein S6 kinase B1
6199 RPS6KB2; ribosomal protein S6 kinase B2
|
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02157 AXIN1; axin 1
K04385 AXIN2; axin 2
K02105 CTNNB1; catenin beta 1
K02085 APC; adenomatosis polyposis coli protein
K02085 APC; adenomatosis polyposis coli protein
K02620 TCF7; transcription factor 7
K04490 TCF7L1; transcription factor 7-like 1
K04491 TCF7L2; transcription factor 7-like 2
K04492 LEF1; lymphoid enhancer-binding factor 1
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K04377 MYC; Myc proto-oncogene protein
K04503 CCND1; G1/S-specific cyclin-D1
K07827 KRAS; GTPase KRas
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K02158 BAD; Bcl-2-antagonist of cell death
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K08845 ARAF; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04448 JUN; transcription factor AP-1
K04379 FOS; proto-oncogene protein c-fos
K08732 RALGDS; ral guanine nucleotide dissociation stimulator
K07834 RALA; Ras-related protein Ral-A
K07835 RALB; Ras-related protein Ral-B
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K04513 RHOA; Ras homolog gene family, member A
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K06765 DCC; deleted in colorectal carcinoma
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K08733 APPL1; DCC-interacting protein 13 alpha
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04500 SMAD2; mothers against decapentaplegic homolog 2
K23605 SMAD3; mothers against decapentaplegic homolog 3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K08734 MLH1; DNA mismatch repair protein MLH1
K08735 MSH2; DNA mismatch repair protein MSH2
K08736 MSH3; DNA mismatch repair protein MSH3
K08737 MSH6; DNA mismatch repair protein MSH6
K02159 BAX; apoptosis regulator BAX
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K16341 BCL2L11; Bcl-2-like protein 11
K10132 BBC3; Bcl-2-binding component 3
K02161 BCL2; apoptosis regulator Bcl-2
K08738 CYC; cytochrome c
K04451 TP53; tumor protein p53
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K14021 BAK; Bcl-2 homologous antagonist/killer
K10140 DDB2; DNA damage-binding protein 2
K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
K04357 EGF; epidermal growth factor
K08774 TGFA; transforming growth factor, alpha
K09784 EREG; epiregulin
K09782 AREG; amphiregulin
K04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-bound protein 2
K03099 SOS; son of sevenless
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07828 NRAS; GTPase NRas
K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
|
05212 Pancreatic cancer [PATH:hsa05212]
|
05225 Hepatocellular carcinoma [PATH:hsa05225]
|
05226 Gastric cancer [PATH:hsa05226]
|
05214 Glioma [PATH:hsa05214]
|
05216 Thyroid cancer [PATH:hsa05216]
|
05221 Acute myeloid leukemia [PATH:hsa05221]
|
05220 Chronic myeloid leukemia [PATH:hsa05220]
|
05217 Basal cell carcinoma [PATH:hsa05217]
|
05218 Melanoma [PATH:hsa05218]
|
05211 Renal cell carcinoma [PATH:hsa05211]
|
05219 Bladder cancer [PATH:hsa05219]
|
05215 Prostate cancer [PATH:hsa05215]
|
05213 Endometrial cancer [PATH:hsa05213]
|
05224 Breast cancer [PATH:hsa05224]
|
05222 Small cell lung cancer [PATH:hsa05222]
|
05223 Non-small cell lung cancer [PATH:hsa05223]
|
|
|
09172 Infectious disease: viral
|
|
|
09171 Infectious disease: bacterial
|
|
|
09174 Infectious disease: parasitic
|
|
|
09163 Immune disease
|
|
|
09164 Neurodegenerative disease
|
|
|
09165 Substance dependence
|
|
|
09166 Cardiovascular disease
|
|
|
09167 Endocrine and metabolic disease
|
|
|
09175 Drug resistance: antimicrobial
|
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09176 Drug resistance: antineoplastic
|
01521 EGFR tyrosine kinase inhibitor resistance [PATH:hsa01521]
|
01524 Platinum drug resistance [PATH:hsa01524]
|
1317 SLC31A1; solute carrier family 31 member 1
540 ATP7B; ATPase copper transporting beta
538 ATP7A; ATPase copper transporting alpha
221357 GSTA5; glutathione S-transferase alpha 5
2939 GSTA2; glutathione S-transferase alpha 2
2941 GSTA4; glutathione S-transferase alpha 4
119391 GSTO2; glutathione S-transferase omega 2
2948 GSTM4; glutathione S-transferase mu 4
2953 GSTT2; glutathione S-transferase theta 2 (gene/pseudogene)
2952 GSTT1; glutathione S-transferase theta 1
2947 GSTM3; glutathione S-transferase mu 3
4257 MGST1; microsomal glutathione S-transferase 1
4259 MGST3; microsomal glutathione S-transferase 3
2944 GSTM1; glutathione S-transferase mu 1
2949 GSTM5; glutathione S-transferase mu 5
4258 MGST2; microsomal glutathione S-transferase 2
2938 GSTA1; glutathione S-transferase alpha 1
2946 GSTM2; glutathione S-transferase mu 2
2940 GSTA3; glutathione S-transferase alpha 3
9446 GSTO1; glutathione S-transferase omega 1
653689 GSTT2B; glutathione S-transferase theta 2B
2950 GSTP1; glutathione S-transferase pi 1
1244 ABCC2; ATP binding cassette subfamily C member 2
5429 POLH; DNA polymerase eta
5980 REV3L; REV3 like, DNA directed polymerase zeta catalytic subunit
4436 MSH2; mutS homolog 2
4437 MSH3; mutS homolog 3
2956 MSH6; mutS homolog 6
4292 MLH1; mutL homolog 1
7507 XPA; XPA, DNA damage recognition and repair factor
2067 ERCC1; ERCC excision repair 1, endonuclease non-catalytic subunit
7155 TOP2B; DNA topoisomerase II beta
7153 TOP2A; DNA topoisomerase II alpha
672 BRCA1; BRCA1 DNA repair associated
472 ATM; ATM serine/threonine kinase
7157 TP53; tumor protein p53
1029 CDKN2A; cyclin dependent kinase inhibitor 2A
4193 MDM2; MDM2 proto-oncogene
355 FAS; Fas cell surface death receptor
581 BAX; BCL2 associated X, apoptosis regulator
578 BAK1; BCL2 antagonist/killer 1
5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
27113 BBC3; BCL2 binding component 3
356 FASLG; Fas ligand
8772 FADD; Fas associated via death domain
841 CASP8; caspase 8
836 CASP3; caspase 3
637 BID; BH3 interacting domain death agonist
329 BIRC2; baculoviral IAP repeat containing 2
330 BIRC3; baculoviral IAP repeat containing 3
331 XIAP; X-linked inhibitor of apoptosis
332 BIRC5; baculoviral IAP repeat containing 5
2064 ERBB2; erb-b2 receptor tyrosine kinase 2
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
5170 PDPK1; 3-phosphoinositide dependent protein kinase 1
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
1026 CDKN1A; cyclin dependent kinase inhibitor 1A
4217 MAP3K5; mitogen-activated protein kinase kinase kinase 5
5594 MAPK1; mitogen-activated protein kinase 1
5595 MAPK3; mitogen-activated protein kinase 3
572 BAD; BCL2 associated agonist of cell death
598 BCL2L1; BCL2 like 1
596 BCL2; BCL2 apoptosis regulator
54205 CYCS; cytochrome c, somatic
317 APAF1; apoptotic peptidase activating factor 1
842 CASP9; caspase 9
|
K14686 SLC31A1; solute carrier family 31 (copper transporter), member 1
K17686 copA; P-type Cu+ transporter [EC:7.2.2.8]
K17686 copA; P-type Cu+ transporter [EC:7.2.2.8]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K00799 GST; glutathione S-transferase [EC:2.5.1.18]
K23790 GSTP; glutathione S-transferase P [EC:2.5.1.18]
K05666 ABCC2; ATP-binding cassette, subfamily C (CFTR/MRP), member 2
K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
K08735 MSH2; DNA mismatch repair protein MSH2
K08736 MSH3; DNA mismatch repair protein MSH3
K08737 MSH6; DNA mismatch repair protein MSH6
K08734 MLH1; DNA mismatch repair protein MLH1
K10847 XPA; DNA-repair protein complementing XP-A cells
K10849 ERCC1; DNA excision repair protein ERCC-1
K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
K04451 TP53; tumor protein p53
K06621 CDKN2A; cyclin-dependent kinase inhibitor 2A
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K04390 TNFRSF6; tumor necrosis factor receptor superfamily member 6
K02159 BAX; apoptosis regulator BAX
K14021 BAK; Bcl-2 homologous antagonist/killer
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K10132 BBC3; Bcl-2-binding component 3
K04389 TNFSF6; tumor necrosis factor ligand superfamily member 6
K02373 FADD; FAS-associated death domain protein
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04726 BID; BH3 interacting domain death agonist
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K05083 ERBB2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K04426 MAP3K5; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K02158 BAD; Bcl-2-antagonist of cell death
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K02161 BCL2; apoptosis regulator Bcl-2
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04399 CASP9; caspase 9 [EC:3.4.22.62]
|
01523 Antifolate resistance [PATH:hsa01523]
|
01522 Endocrine resistance [PATH:hsa01522]
|
|
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09180 Brite Hierarchies
|
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09190 Not Included in Pathway or Brite
|