1. Oxidoreductases

 2. Transferases

   2.1  Transferring one-carbon groups

   2.2  Transferring aldehyde or ketonic groups

   2.3  Acyltransferases

   2.4  Glycosyltransferases

   2.5  Transferring alkyl or aryl groups, other than methyl groups

     2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

       2.5.1.1  dimethylallyltranstransferase

       2.5.1.2  thiamine pyridinylase

       2.5.1.3  thiamine phosphate synthase

       2.5.1.5  galactose-6-sulfurylase

       2.5.1.6  methionine adenosyltransferase

       2.5.1.7  UDP-N-acetylglucosamine 1-carboxyvinyltransferase

       2.5.1.9  riboflavin synthase

       2.5.1.10  (2E,6E)-farnesyl diphosphate synthase

       2.5.1.15  dihydropteroate synthase

       2.5.1.16  spermidine synthase

       2.5.1.17  corrinoid adenosyltransferase

       2.5.1.18  glutathione transferase

       2.5.1.19  3-phosphoshikimate 1-carboxyvinyltransferase

       2.5.1.20  rubber cis-polyprenylcistransferase

       2.5.1.21  squalene synthase

       2.5.1.22  spermine synthase

       2.5.1.23  sym-norspermidine synthase

       2.5.1.24  discadenine synthase

       2.5.1.25  tRNA-uridine aminocarboxypropyltransferase

       2.5.1.26  alkylglycerone-phosphate synthase

       2.5.1.27  adenylate dimethylallyltransferase (AMP-dependent)

       2.5.1.28  dimethylallylcistransferase

       2.5.1.29  geranylgeranyl diphosphate synthase

       2.5.1.30  heptaprenyl diphosphate synthase

       2.5.1.31  ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]

       2.5.1.32  15-cis-phytoene synthase

       2.5.1.34  4-dimethylallyltryptophan synthase

       2.5.1.35  aspulvinone dimethylallyltransferase

       2.5.1.36  trihydroxypterocarpan dimethylallyltransferase

       2.5.1.38  isonocardicin synthase

       2.5.1.39  4-hydroxybenzoate polyprenyltransferase

       2.5.1.41  phosphoglycerol geranylgeranyltransferase

       2.5.1.42  geranylgeranylglycerol-phosphate geranylgeranyltransferase

       2.5.1.43  nicotianamine synthase

       2.5.1.44  homospermidine synthase

       2.5.1.45  homospermidine synthase (spermidine-specific)

       2.5.1.46  deoxyhypusine synthase

       2.5.1.47  cysteine synthase

       2.5.1.48  cystathionine gamma-synthase

       2.5.1.49  O-acetylhomoserine aminocarboxypropyltransferase

       2.5.1.50  zeatin 9-aminocarboxyethyltransferase

       2.5.1.51  beta-pyrazolylalanine synthase

       2.5.1.52  L-mimosine synthase

       2.5.1.53  uracilylalanine synthase

       2.5.1.54  3-deoxy-7-phosphoheptulonate synthase

       2.5.1.55  3-deoxy-8-phosphooctulonate synthase

       2.5.1.56  N-acetylneuraminate synthase

       2.5.1.57  N-acylneuraminate-9-phosphate synthase

       2.5.1.58  protein farnesyltransferase

       2.5.1.59  protein geranylgeranyltransferase type I

       2.5.1.60  protein geranylgeranyltransferase type II

       2.5.1.61  hydroxymethylbilane synthase

       2.5.1.62  chlorophyll synthase

       2.5.1.63  adenosyl-fluoride synthase

       2.5.1.65  O-phosphoserine sulfhydrylase

       2.5.1.66  N2-(2-carboxyethyl)arginine synthase

       2.5.1.67  chrysanthemyl diphosphate synthase

       2.5.1.68  (2Z,6E)-farnesyl diphosphate synthase

       2.5.1.69  lavandulyl diphosphate synthase

       2.5.1.70  naringenin 8-dimethylallyltransferase

       2.5.1.71  leachianone-G 2''-dimethylallyltransferase

       2.5.1.72  quinolinate synthase

       2.5.1.73  O-phospho-L-seryl-tRNA:Cys-tRNA synthase

       2.5.1.74  1,4-dihydroxy-2-naphthoate polyprenyltransferase

       2.5.1.75  tRNA dimethylallyltransferase

       2.5.1.76  cysteate synthase

       2.5.1.78  6,7-dimethyl-8-ribityllumazine synthase

       2.5.1.79  thermospermine synthase

       2.5.1.80  7-dimethylallyltryptophan synthase

       2.5.1.81  geranylfarnesyl diphosphate synthase

       2.5.1.82  hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]

       2.5.1.83  hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]

       2.5.1.84  all-trans-nonaprenyl diphosphate synthase [geranyl-diphosphate specific]

       2.5.1.85  all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]

       2.5.1.86  trans,polycis-decaprenyl diphosphate synthase

       2.5.1.87  ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]

       2.5.1.88  trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]

       2.5.1.89  tritrans,polycis-undecaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]

       2.5.1.90  all-trans-octaprenyl-diphosphate synthase

       2.5.1.91  all-trans-decaprenyl-diphosphate synthase

       2.5.1.92  (2Z,6Z)-farnesyl diphosphate synthase

       2.5.1.93  4-hydroxybenzoate geranyltransferase

       2.5.1.94  adenosyl-chloride synthase

       2.5.1.95  xanthan ketal pyruvate transferase

       2.5.1.96  4,4'-diapophytoene synthase

       2.5.1.97  pseudaminic acid synthase

       2.5.1.98  Rhizobium leguminosarum exopolysaccharide glucosyl ketal-pyruvate-transferase

       2.5.1.100  fumigaclavine A dimethylallyltransferase

       2.5.1.101  N,N'-diacetyllegionaminate synthase

       2.5.1.102  geranyl-pyrophosphate---olivetolic acid geranyltransferase

       2.5.1.103  presqualene diphosphate synthase

       2.5.1.104  N1-aminopropylagmatine synthase

       2.5.1.105  7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase

       2.5.1.106  tryprostatin B synthase

       2.5.1.107  verruculogen prenyltransferase

       2.5.1.108  2-(3-amino-3-carboxypropyl)histidine synthase

       2.5.1.109  brevianamide F prenyltransferase (deoxybrevianamide E-forming)

       2.5.1.110  12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase

       2.5.1.111  4-hydroxyphenylpyruvate 3-dimethylallyltransferase

       2.5.1.112  adenylate dimethylallyltransferase (ADP/ATP-dependent)

       2.5.1.113  [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase

       2.5.1.114  tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase

       2.5.1.115  homogentisate phytyltransferase

       2.5.1.116  homogentisate geranylgeranyltransferase

       2.5.1.117  homogentisate solanesyltransferase

       2.5.1.118  beta-(isoxazolin-5-on-2-yl)-L-alanine synthase

       2.5.1.119  beta-(isoxazolin-5-on-4-yl)-L-alanine synthase

       2.5.1.120  aminodeoxyfutalosine synthase

       2.5.1.121  5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase

       2.5.1.122  4-O-dimethylallyl-L-tyrosine synthase

       2.5.1.123  flaviolin linalyltransferase

       2.5.1.124  6-linalyl-2-O,3-dimethylflaviolin synthase

       2.5.1.125  7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase

       2.5.1.126  norspermine synthase

       2.5.1.127  caldopentamine synthase

       2.5.1.128  N4-bis(aminopropyl)spermidine synthase

       2.5.1.129  flavin prenyltransferase

       2.5.1.130  2-carboxy-1,4-naphthoquinone phytyltransferase

       2.5.1.131  (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase

       2.5.1.132  3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase

       2.5.1.133  bacteriochlorophyll a synthase

       2.5.1.134  cystathionine beta-synthase (O-acetyl-L-serine)

       2.5.1.135  validamine 7-phosphate valienyltransferase

       2.5.1.136  2-acylphloroglucinol 4-prenyltransferase

       2.5.1.137  2-acyl-4-prenylphloroglucinol 6-prenyltransferase

       2.5.1.138  coumarin 8-geranyltransferase

       2.5.1.139  umbelliferone 6-dimethylallyltransferase

       2.5.1.140  N-(2-amino-2-carboxyethyl)-L-glutamate synthase

       2.5.1.141  heme o synthase

       2.5.1.142  nerylneryl diphosphate synthase

       2.5.1.143  pyridinium-3,5-biscarboxylic acid mononucleotide synthase

       2.5.1.144  S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent)

       2.5.1.145  phosphatidylglycerol---prolipoprotein diacylglyceryl transferase

       2.5.1.146  3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase

       2.5.1.147  5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase

       2.5.1.148  lycopaoctaene synthase

       2.5.1.149  lycopene elongase/hydratase (flavuxanthin-forming)

       2.5.1.150  lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming)

       2.5.1.151  alkylcobalamin dealkylase

       2.5.1.152  D-histidine 2-aminobutanoyltransferase

       2.5.1.153  adenosine tuberculosinyltransferase

       2.5.1.154  corrinoid adenosyltransferase EutT

       2.5.1.155  phosphoglycerol geranylfarnesyltransferase

       2.5.1.156  geranylfarnesylglycerol-phosphate geranylfarnesyltransferase

       2.5.1.157  rRNA small subunit aminocarboxypropyltransferase

       2.5.1.158  hexaprenyl diphosphate synthase (prenyl-diphosphate specific)

       2.5.1.159  hapalindole G dimethylallyltransferase

   2.6  Transferring nitrogenous groups

   2.7  Transferring phosphorus-containing groups

   2.8  Transferring sulfur-containing groups

   2.9  Transferring selenium-containing groups

   2.10  Transferring molybdenum- or tungsten-containing groups

 3. Hydrolases

 4. Lyases

 5. Isomerases

 6. Ligases

   6.1  Forming carbon-oxygen bonds

   6.2  Forming carbon-sulfur bonds

   6.3  Forming carbon-nitrogen bonds

     6.3.1  Acid-D-ammonia (or amine) ligases (amide synthases)

     6.3.2  Acid-D-amino-acid ligases (peptide synthases)

       6.3.2.1  pantoate---beta-alanine ligase (AMP-forming)

       6.3.2.2  glutamate---cysteine ligase

       6.3.2.3  glutathione synthase

       6.3.2.4  D-alanine---D-alanine ligase

       6.3.2.5  phosphopantothenate---cysteine ligase (CTP)

       6.3.2.6  phosphoribosylaminoimidazolesuccinocarboxamide synthase

       6.3.2.7  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase

       6.3.2.8  UDP-N-acetylmuramate---L-alanine ligase

       6.3.2.9  UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase

       6.3.2.10  UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase

       6.3.2.11  carnosine synthase

       6.3.2.12  dihydrofolate synthase

       6.3.2.13  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase

       6.3.2.14  enterobactin synthase

       6.3.2.16  D-alanine---alanyl-poly(glycerolphosphate) ligase

       6.3.2.17  tetrahydrofolate synthase

       6.3.2.18  gamma-glutamylhistamine synthase

       6.3.2.20  indoleacetate---lysine synthetase

       6.3.2.23  homoglutathione synthase

       6.3.2.24  tyrosine---arginine ligase

       6.3.2.25  tubulin---tyrosine ligase

       6.3.2.26  N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

       6.3.2.29  cyanophycin synthase (L-aspartate-adding)

       6.3.2.30  cyanophycin synthase (L-arginine-adding)

       6.3.2.31  coenzyme F420-0:L-glutamate ligase

       6.3.2.32  coenzyme gamma-F420-2:alpha-L-glutamate ligase

       6.3.2.33  tetrahydrosarcinapterin synthase

       6.3.2.34  coenzyme F420-1:gamma-L-glutamate ligase

       6.3.2.35  D-alanine---D-serine ligase

       6.3.2.36  4-phosphopantoate---beta-alanine ligase

       6.3.2.37  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---D-lysine ligase

       6.3.2.38  N2-citryl-N6-acetyl-N6-hydroxylysine synthase

       6.3.2.39  aerobactin synthase

       6.3.2.40  cyclopeptine synthase

       6.3.2.41  N-acetylaspartylglutamate synthase

       6.3.2.42  N-acetylaspartylglutamylglutamate synthase

       6.3.2.43  [amino-group carrier protein]---L-2-aminoadipate ligase

       6.3.2.44  pantoate---beta-alanine ligase (ADP-forming)

       6.3.2.45  UDP-N-acetylmuramate---L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase

       6.3.2.46  fumarate---(S)-2,3-diaminopropanoate ligase

       6.3.2.47  dapdiamide synthase

       6.3.2.48  L-arginine-specific L-amino acid ligase

       6.3.2.49  L-alanine---L-anticapsin ligase

       6.3.2.50  tenuazonic acid synthetase

       6.3.2.51  phosphopantothenate---cysteine ligase (ATP)

       6.3.2.52  jasmonoyl---L-amino acid ligase

       6.3.2.53  UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase

       6.3.2.54  L-2,3-diaminopropanoate---citrate ligase

       6.3.2.55  2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase

       6.3.2.56  staphyloferrin B synthase

       6.3.2.57  staphyloferrin A synthase

       6.3.2.58  D-ornithine---citrate ligase

       6.3.2.59  3-methyl-D-ornithine---L-lysine ligase

       6.3.2.60  glutamate---[amino group carrier protein] ligase

       6.3.2.61  tubulin-glutamate ligase

       6.3.2.62  beta-tubulin-glutamate ligase

       6.3.2.63  putrebactin synthase

       6.3.2.64  bisucaberin synthase

     6.3.3  Cyclo-ligases

     6.3.4  Other carbon-nitrogen ligases

     6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor

   6.4  Forming carbon-carbon bonds

   6.5  Forming phosphoric-ester bonds

   6.6  Forming nitrogen-metal bonds

   6.7  Forming nitrogen-nitrogen bonds

 7. Translocases