KEGG Orthology (KO)

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 Metabolism
 
   Carbohydrate metabolism
 
   Energy metabolism
 
   Lipid metabolism
 
   Nucleotide metabolism
 
   Amino acid metabolism
 
   Metabolism of other amino acids
     00410 beta-Alanine metabolism [PATH:ko00410]
     00430 Taurine and hypotaurine metabolism [PATH:ko00430]
     00440 Phosphonate and phosphinate metabolism [PATH:ko00440]
     00450 Selenocompound metabolism [PATH:ko00450]
     00460 Cyanoamino acid metabolism [PATH:ko00460]
     00471 D-Glutamine and D-glutamate metabolism [PATH:ko00471]
     00472 D-Arginine and D-ornithine metabolism [PATH:ko00472]
     00473 D-Alanine metabolism [PATH:ko00473]
     00480 Glutathione metabolism [PATH:ko00480]
       K00681  ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
       K18592  GGT1_5, CD224; gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase [EC:2.3.2.2 3.4.19.13 3.4.19.14]
       K00682  GGCT; gamma-glutamylcyclotransferase [EC:2.3.2.4]
       K01469  OPLAH, OXP1, oplAH; 5-oxoprolinase (ATP-hydrolysing) [EC:3.5.2.9]
       K11204  GCLC; glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]
       K11205  GCLM; glutamate--cysteine ligase regulatory subunit
       K01919  gshA; glutamate--cysteine ligase [EC:6.3.2.2]
       K01920  gshB; glutathione synthase [EC:6.3.2.3]
       K21456  GSS; glutathione synthase [EC:6.3.2.3]
       K11142  LAP3; cytosol aminopeptidase [EC:3.4.11.1 3.4.11.5]
       K01255  CARP, pepA; leucyl aminopeptidase [EC:3.4.11.1]
       K07751  pepB; PepB aminopeptidase [EC:3.4.11.23]
       K11140  ANPEP, CD13; aminopeptidase N [EC:3.4.11.2]
       K01256  pepN; aminopeptidase N [EC:3.4.11.2]
       K01270  pepD; dipeptidase D [EC:3.4.13.-]
       K15428  DUG1; Cys-Gly metallodipeptidase DUG1 [EC:3.4.13.-]
       K00799  GST, gst; glutathione S-transferase [EC:2.5.1.18]
       K13299  GSTK1; glutathione S-transferase kappa 1 [EC:2.5.1.18]
       K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]
       K21888  DHAR; glutathione dehydrogenase/transferase [EC:1.8.5.1 2.5.1.18]
       K20838  NAT8; N-acetyltransferase 8 [EC:2.3.1.80 2.3.1.-]
       K00383  GSR, gor; glutathione reductase (NADPH) [EC:1.8.1.7]
       K00031  IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]
       K00032  E1.1.1.43; phosphogluconate 2-dehydrogenase [EC:1.1.1.43]
       K00033  PGD, gnd, gntZ; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]
       K00036  G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
       K05360  TXNDC12; protein-disulfide reductase (glutathione) [EC:1.8.4.2]
       K00432  gpx; glutathione peroxidase [EC:1.11.1.9]
       K05361  GPX4; phospholipid-hydroperoxide glutathione peroxidase [EC:1.11.1.12]
       K00310  SE; pyrimidodiazepine synthase [EC:1.5.4.1]
       K01581  E4.1.1.17, ODC1, speC, speF; ornithine decarboxylase [EC:4.1.1.17]
       K00797  speE, SRM; spermidine synthase [EC:2.5.1.16]
       K01917  E6.3.1.8; glutathionylspermidine synthase [EC:6.3.1.8]
       K01460  gsp; glutathionylspermidine amidase/synthetase [EC:3.5.1.78 6.3.1.8]
       K00802  SMS; spermine synthase [EC:2.5.1.22]
       K01833  TRYS; trypanothione synthetase/amidase [EC:6.3.1.9 3.5.1.-]
       K04283  TRYR; trypanothione-disulfide reductase [EC:1.8.1.12]
       K00434  E1.11.1.11; L-ascorbate peroxidase [EC:1.11.1.11]
       K11185  TRYP; cytosolic tryparedoxin peroxidase, trypanosomatid typical 2-Cys peroxiredoxin [EC:1.11.1.15]
       K11186  MTRYP; mitochondrial tryparedoxin peroxidase, trypanosomatid typical 2-Cys peroxiredoxin [EC:1.11.1.15]
       K11207  TDPX; glutathione peroxidase-type tryparedoxin peroxidase [EC:1.11.1.-]
       K10807  RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
       K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
 
   Glycan biosynthesis and metabolism
 
   Metabolism of cofactors and vitamins
 
   Metabolism of terpenoids and polyketides
 
   Biosynthesis of other secondary metabolites
 
   Xenobiotics biodegradation and metabolism
     00362 Benzoate degradation [PATH:ko00362]
     00627 Aminobenzoate degradation [PATH:ko00627]
     00364 Fluorobenzoate degradation [PATH:ko00364]
     00625 Chloroalkane and chloroalkene degradation [PATH:ko00625]
     00361 Chlorocyclohexane and chlorobenzene degradation [PATH:ko00361]
     00623 Toluene degradation [PATH:ko00623]
     00622 Xylene degradation [PATH:ko00622]
     00633 Nitrotoluene degradation [PATH:ko00633]
     00642 Ethylbenzene degradation [PATH:ko00642]
     00643 Styrene degradation [PATH:ko00643]
     00791 Atrazine degradation [PATH:ko00791]
     00930 Caprolactam degradation [PATH:ko00930]
     00351 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation [PATH:ko00351]
     00363 Bisphenol degradation [PATH:ko00363]
     00621 Dioxin degradation [PATH:ko00621]
     00626 Naphthalene degradation [PATH:ko00626]
     00624 Polycyclic aromatic hydrocarbon degradation [PATH:ko00624]
     00365 Furfural degradation [PATH:ko00365]
     00984 Steroid degradation [PATH:ko00984]
     00980 Metabolism of xenobiotics by cytochrome P450 [PATH:ko00980]
       K07408  CYP1A1; cytochrome P450 family 1 subfamily A polypeptide 1 [EC:1.14.14.1]
       K17719  CYP2C9; cytochrome P450 family 2 subfamily C polypeptide 9 [EC:1.14.13.48 1.14.13.49 1.14.13.80 1.14.13.-]
       K17689  CYP3A4; cytochrome P450 family 3 subfamily A polypeptide 4 [EC:1.14.13.32 1.14.13.67 1.14.13.97 1.14.13.157 1.14.13.-]
       K07410  CYP1B1; cytochrome P450 family 1 subfamily B polypeptide 1 [EC:1.14.14.1]
       K00799  GST, gst; glutathione S-transferase [EC:2.5.1.18]
       K13299  GSTK1; glutathione S-transferase kappa 1 [EC:2.5.1.18]
       K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]
       K01253  EPHX1; microsomal epoxide hydrolase [EC:3.3.2.9]
       K17709  CYP2B6; cytochrome P450 family 2 subfamily B polypeptide 6 [EC:1.14.13.-]
       K11822  SULT2A1; bile-salt sulfotransferase [EC:2.8.2.14]
       K07409  CYP1A2; cytochrome P450 family 1 subfamily A polypeptide 2 [EC:1.14.14.1]
       K17683  CYP2A6; cytochrome P450 family 2 subfamily A polypeptide 6 [EC:1.14.13.-]
       K07415  CYP2E1; cytochrome P450 family 2 subfamily E polypeptide 1 [EC:1.14.13.-]
       K07416  CYP2F; cytochrome P450 family 2 subfamily F [EC:1.14.14.1]
       K07420  CYP2S1; cytochrome P450 family 2 subfamily S polypeptide 1 [EC:1.14.14.1]
       K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase [EC:1.1.1.149 1.1.1.357 1.3.1.20]
       K00078  DHDH; dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP) [EC:1.3.1.20 1.1.1.179]
       K17685  CYP2A13; cytochrome P450 family 2 subfamily A polypeptide 13 [EC:1.14.14.1]
       K17712  CYP2D6; cytochrome P450 family 2 subfamily D polypeptide 6 [EC:1.14.14.1]
       K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]
       K00079  CBR1; carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]
       K00081  CBR2; carbonyl reductase 2 [EC:1.1.1.184]
       K00084  CBR3; carbonyl reductase 3 [EC:1.1.1.184]
       K00699  UGT; glucuronosyltransferase [EC:2.4.1.17]
       K17690  CYP3A5; cytochrome P450 family 3 subfamily A polypeptide 5 [EC:1.14.14.1]
       K15303  AKR7; aflatoxin B1 aldehyde reductase
       K00129  E1.2.1.5; aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
       K13951  ADH1_7; alcohol dehydrogenase 1/7 [EC:1.1.1.1]
       K13980  ADH4; alcohol dehydrogenase 4 [EC:1.1.1.1]
       K00121  frmA, ADH5, adhC; S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
       K13952  ADH6; alcohol dehydrogenase 6 [EC:1.1.1.1]
       K13953  adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
       K00001  E1.1.1.1, adh; alcohol dehydrogenase [EC:1.1.1.1]
     00982 Drug metabolism - cytochrome P450 [PATH:ko00982]
       K17712  CYP2D6; cytochrome P450 family 2 subfamily D polypeptide 6 [EC:1.14.14.1]
       K17719  CYP2C9; cytochrome P450 family 2 subfamily C polypeptide 9 [EC:1.14.13.48 1.14.13.49 1.14.13.80 1.14.13.-]
       K17689  CYP3A4; cytochrome P450 family 3 subfamily A polypeptide 4 [EC:1.14.13.32 1.14.13.67 1.14.13.97 1.14.13.157 1.14.13.-]
       K00485  FMO; dimethylaniline monooxygenase (N-oxide forming) [EC:1.14.13.8]
       K17721  CYP2C19; cytochrome P450 family 2 subfamily C polypeptide 19 [EC:1.14.13.48 1.14.13.49 1.14.13.80 1.14.13.-]
       K17709  CYP2B6; cytochrome P450 family 2 subfamily B polypeptide 6 [EC:1.14.13.-]
       K17690  CYP3A5; cytochrome P450 family 3 subfamily A polypeptide 5 [EC:1.14.14.1]
       K00799  GST, gst; glutathione S-transferase [EC:2.5.1.18]
       K13299  GSTK1; glutathione S-transferase kappa 1 [EC:2.5.1.18]
       K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]
       K13951  ADH1_7; alcohol dehydrogenase 1/7 [EC:1.1.1.1]
       K13980  ADH4; alcohol dehydrogenase 4 [EC:1.1.1.1]
       K00121  frmA, ADH5, adhC; S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
       K13952  ADH6; alcohol dehydrogenase 6 [EC:1.1.1.1]
       K13953  adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
       K00001  E1.1.1.1, adh; alcohol dehydrogenase [EC:1.1.1.1]
       K00129  E1.2.1.5; aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
       K00274  MAO, aofH; monoamine oxidase [EC:1.4.3.4]
       K00157  AOX; aldehyde oxidase [EC:1.2.3.1]
       K00699  UGT; glucuronosyltransferase [EC:2.4.1.17]
       K07409  CYP1A2; cytochrome P450 family 1 subfamily A polypeptide 2 [EC:1.14.14.1]
       K07415  CYP2E1; cytochrome P450 family 2 subfamily E polypeptide 1 [EC:1.14.13.-]
       K17718  CYP2C8; cytochrome P450 family 2 subfamily C polypeptide 8 [EC:1.14.14.1]
       K17683  CYP2A6; cytochrome P450 family 2 subfamily A polypeptide 6 [EC:1.14.13.-]
     00983 Drug metabolism - other enzymes [PATH:ko00983]
 
   Enzyme families
 
 Genetic Information Processing
 
 Environmental Information Processing
 
 Cellular Processes
 
 Organismal Systems
 
 Human Diseases
 
   Cancers
     05200 Pathways in cancer [PATH:ko05200]
       K06765  DCC; deleted in colorectal carcinoma
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K08733  APPL1, DIP13A; DCC-interacting protein 13 alpha
       K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
       K02105  CTNNB1; catenin beta 1
       K05691  CTNNA; catenin alpha
       K02157  AXIN1; axin 1
       K04385  AXIN2; axin 2
       K02085  APC; adenomatosis polyposis coli protein
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K02620  TCF7; transcription factor 7
       K04490  TCF7L1; transcription factor 7-like 1
       K04491  TCF7L2; transcription factor 7-like 2
       K04492  LEF1; lymphoid enhancer-binding factor 1
       K08731  BIRC5; baculoviral IAP repeat-containing protein 5
       K04377  MYC; Myc proto-oncogene protein
       K04503  CCND1; G1/S-specific cyclin-D1
       K03209  WNT1; wingless-type MMTV integration site family, member 1
       K00182  WNT2; wingless-type MMTV integration site family, member 2
       K00312  WNT3; wingless-type MMTV integration site family, member 3
       K00408  WNT4; wingless-type MMTV integration site family, member 4
       K00444  WNT5; wingless-type MMTV integration site family, member 5
       K00445  WNT6; wingless-type MMTV integration site family, member 6
       K00572  WNT7; wingless-type MMTV integration site family, member 7
       K00714  WNT8; wingless-type MMTV integration site family, member 8
       K01064  WNT9; wingless-type MMTV integration site family, member 9
       K01357  WNT10; wingless-type MMTV integration site family, member 10
       K01384  WNT11; wingless-type MMTV integration site family, member 11
       K01558  WNT16; wingless-type MMTV integration site family, member 16
       K02432  FZD1_7, fz; frizzled 1/7
       K02235  FZD2; frizzled 2
       K02329  FZD3; frizzled 3
       K02354  FZD4, fz4, CD344; frizzled 4
       K02375  FZD5_8, fz2; frizzled 5/8
       K02376  FZD6; frizzled 6
       K02842  FZD9_10, CD349_50; frizzled 9/10
       K03068  LRP5_6; low density lipoprotein receptor-related protein 5/6
       K02353  DVL; segment polarity protein dishevelled
       K03069  FRAT1; frequently rearranged in advanced T-cell lymphomas 1
       K03096  FRAT2; frequently rearranged in advanced T-cell lymphomas 2
       K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
       K04236  F2RL3, PAR4; coagulation factor II (thrombin) receptor-like 3
       K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
       K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
       K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
       K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
       K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
       K04273  LPAR6, P2RY5; lysophosphatidic acid receptor 6
       K04166  AGTR1; angiotensin II receptor type 1
       K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
       K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
       K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
       K12331  ARHGEF11; Rho guanine nucleotide exchange factor 11
       K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
       K19464  PLEKHG5; pleckstrin homology domain-containing family G member 5
       K04513  RHOA; Ras homolog gene family, member A
       K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
       K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
       K10031  CXCL12; C-X-C motif chemokine 12
       K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K04258  PTGER1; prostaglandin E receptor 1
       K04259  PTGER2; prostaglandin E receptor 2
       K04260  PTGER3; prostaglandin E receptor 3
       K04261  PTGER4; prostaglandin E receptor 4
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K04536  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
       K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
       K07825  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
       K04538  GNB4; guanine nucleotide-binding protein subunit beta-4
       K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
       K07826  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
       K04540  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
       K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
       K04542  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
       K04543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
       K04544  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
       K04545  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
       K04546  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K04547  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
       K04548  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
       K04549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
       K06237  COL4A; collagen, type IV, alpha
       K05637  LAMA1_2; laminin, alpha 1/2
       K06240  LAMA3_5; laminin, alpha 3/5
       K06241  LAMA4; laminin, alpha 4
       K05636  LAMB1; laminin, beta 1
       K06243  LAMB2; laminin, beta 2
       K06244  LAMB3; laminin, beta 3
       K06245  LAMB4; laminin, beta 4
       K05635  LAMC1; laminin, gamma 1
       K06246  LAMC2; laminin, gamma 2
       K06247  LAMC3; laminin, gamma 3
       K05717  FN1; fibronectin 1
       K06481  ITGA2, CD49b; integrin alpha 2
       K06476  ITGA2B, CD41; integrin alpha 2B
       K06482  ITGA3, CD49c; integrin alpha 3
       K06485  ITGA6, CD49f; integrin alpha 6
       K06487  ITGAV, CD51; integrin alpha V
       K05719  ITGB1, CD29; integrin beta 1
       K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
       K09348  NKX3-1; homeobox protein Nkx-3.1
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04469  NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
       K04735  RELA; transcription factor p65
       K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
       K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
       K02161  BCL2; apoptosis regulator Bcl-2
       K16060  BIRC2_3; baculoviral IAP repeat-containing protein 2/3
       K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
       K16061  BIRC7_8; baculoviral IAP repeat-containing protein 7/8
       K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
       K03172  TRAF1; TNF receptor-associated factor 1
       K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
       K03174  TRAF3; TNF receptor-associated factor 3
       K09848  TRAF4; TNF receptor-associated factor 4
       K09849  TRAF5; TNF receptor-associated factor 5
       K03175  TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
       K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
       K04688  RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
       K02158  BAD; Bcl-2-antagonist of cell death
       K07201  FOXO1; forkhead box protein O1
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
       K04451  TP53, P53; tumor protein p53
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K08878  BCR1, BCR; breakpoint cluster region protein [EC:2.7.11.1]
       K06619  ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
       K04438  CRK, CRKII; proto-oncogene C-crk
       K04707  CBL; E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]
       K11223  STAT5A; signal transducer and activator of transcription 5A
       K11224  STAT5B; signal transducer and activator of transcription 5B
       K04702  PIM1; proto-oncogene serine/threonine-protein kinase Pim-1 [EC:2.7.11.1]
       K08806  PIM2; proto-oncogene serine/threonine-protein kinase Pim-2 [EC:2.7.11.1]
       K03915  BDKRB1; bradykinin receptor B1
       K03916  BDKRB2; bradykinin receptor B2
       K04197  EDNRA; endothelin receptor type A
       K04198  EDNRB; endothelin receptor type B
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K02677  PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
       K19662  PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
       K19663  PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
       K05429  IL2; interleukin 2
       K04736  IL3; interleukin 3
       K05430  IL4; interleukin 4
       K05428  IL5; interleukin 5
       K05431  IL7; interleukin 7
       K05406  IL12A; interleukin 12A
       K05425  IL12B; interleukin 12B
       K05435  IL13; interleukin 13
       K05433  IL15; interleukin 15
       K05426  IL23A; interleukin 23, alpha subunit p19
       K05437  EPO; erythropoietin
       K05414  IFNA; interferon alpha
       K04687  IFNG; interferon gamma
       K05068  IL2RA, CD25; interleukin 2 receptor alpha
       K05069  IL2RB, CD122; interleukin 2 receptor beta
       K05070  IL2RG, CD132; interleukin 2 receptor gamma
       K04737  IL3RA, CD123; interleukin 3 receptor alpha
       K05071  IL4R, CD124; interleukin 4 receptor
       K04738  CSF2RB, IL3RB, CD131; cytokine receptor common subunit beta
       K05067  IL5RA. CD125; interleukin 5 receptor alpha
       K05055  IL6R, CD126; interleukin 6 receptor
       K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
       K05072  IL7R, CD127; interleukin 7 receptor
       K05063  IL12RB1, CD212; interleukin 12 receptor beta-1
       K05064  IL12RB2; interleukin 12 receptor beta-2
       K05076  IL13RA1, CD213A1; interleukin 13 receptor alpha-1
       K05074  IL15RA, CD215; interleukin 15 receptor alpha
       K05065  IL23R; interleukin 23 receptor
       K05079  EPOR; erythropoietin receptor
       K05130  IFNAR1; interferon receptor 1
       K05131  IFNAR2; interferon receptor 2
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K15420  EML4; echinoderm microtubule-associated protein-like 4
       K05119  ALK, CD246; anaplastic lymphoma kinase [EC:2.7.10.1]
       K04350  RASGRP1; RAS guanyl-releasing protein 1
       K12361  RASGRP2; RAS guanyl-releasing protein 2
       K12362  RASGRP3; RAS guanyl-releasing protein 3
       K12363  RASGRP4; RAS guanyl-releasing protein 4
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
       K11218  JAK3; Janus kinase 3 [EC:2.7.10.2]
       K04692  STAT3; signal transducer and activator of transcription 3
       K11220  STAT1; signal transducer and activator of transcription 1
       K11221  STAT2; signal transducer and activator of transcription 2
       K11222  STAT4; signal transducer and activator of transcription 4
       K11225  STAT6; signal transducer and activator of transcription 6
       K05448  VEGFA; vascular endothelial growth factor A
       K16858  VEGFB; vascular endothelial growth factor B
       K16859  PGF; placenta growth factor
       K05449  VEGFC_D; vascular endothelial growth factor C/D
       K08774  TGFA; transforming growth factor, alpha
       K04357  EGF; epidermal growth factor
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K05459  IGF1; insulin-like growth factor 1
       K13769  IGF2; insulin-like growth factor 2
       K05087  IGF1R, CD221; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K05461  KITLG; KIT ligand
       K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
       K05454  FLT3LG; fms-related tyrosine kinase 3 ligand
       K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3 [EC:2.7.10.1]
       K05460  HGF; hepatocyte growth factor
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
       K18496  FGF1; fibroblast growth factor 1
       K18497  FGF2; fibroblast growth factor 2
       K04358  FGF; fibroblast growth factor
       K04362  FGFR1, CD331; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K05093  FGFR2, CD332; fibroblast growth factor receptor 2 [EC:2.7.10.1]
       K05094  FGFR3, CD333; fibroblast growth factor receptor 3 [EC:2.7.10.1]
       K05095  FGFR4, CD334; fibroblast growth factor receptor 4 [EC:2.7.10.1]
       K04364  GRB2; growth factor receptor-binding protein 2
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04448  JUN; transcription factor AP-1
       K04379  FOS; proto-oncogene protein c-fos
       K02678  ETS1, pnt; C-ets-1
       K01388  MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
       K01398  MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
       K01403  MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
       K10030  IL8, CXCL8; interleukin 8
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K04445  RPS6KA5, MSK1; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
       K05126  RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
       K09288  CCDC6, PTC; coiled-coil domain-containing protein 6
       K09289  NCOA4, PTC3; nuclear receptor coactivator 4
       K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
       K09290  TPM3; tropomyosin 3
       K09291  TPR, MLP1, MLP2; nucleoprotein TPR
       K09292  TFG; protein TFG
       K09850  RASSF1; Ras association domain-containing protein 1
       K08015  RASSF5, RAPL; Ras association domain-containing protein 5
       K04411  STK4, MST1; serine/threonine kinase 4
       K08803  DAPK; death-associated protein kinase [EC:2.7.11.1]
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K04375  ELK1; ETS domain-containing protein Elk-1
       K02183  CALM; calmodulin
       K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
       K08732  RALGDS; ral guanine nucleotide dissociation stimulator
       K07834  RALA; Ras-related protein Ral-A
       K07835  RALB; Ras-related protein Ral-B
       K08773  RALBP1; RalA-binding protein 1
       K04393  CDC42; cell division control protein 42
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K09293  PAX8; paired box protein 8
       K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
       K08524  RXRA, NR2B1; retinoid X receptor alpha
       K08525  RXRB, NR2B2; retinoid X receptor beta
       K08526  RXRG, NR2B3; retinoid X receptor gamma
       K08528  RARB, NR1B2; retinoic acid receptor beta
       K08550  ESR1, NR3A1; estrogen receptor alpha
       K08551  ESR2, NR3A2; estrogen receptor beta
       K09101  NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1 [EC:2.3.1.48]
       K11256  NCOA3, ACTR, KAT13B; nuclear receptor coactivator 3 [EC:2.3.1.48]
       K04684  SP1; transcription factor Sp1
       K04504  NR1C2, PPARD; peroxisome proliferator-activated receptor delta
       K10056  JUP; junction plakoglobin
       K10055  ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
       K10054  PML, TRIM19; probable transcription factor PML
       K08527  RARA, NR1B1; retinoic acid receptor alpha
       K08367  RUNX1, AML1; runt-related transcription factor 1
       K10053  RUNX1T1, CBFA2T1; runt-related transcription factor 1; translocated to, 1
       K09438  SPI1; transcription factor PU.1
       K09055  CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
       K05066  CSF2RA, GMCSFR, CD116; granulocyte-macrophage colony-stimulating factor receptor alpha
       K05061  CSF3R, CD114; granulocyte colony-stimulating factor receptor
       K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
       K17454  E2F1; transcription factor E2F1
       K09389  E2F2; transcription factor E2F2
       K06620  E2F3; transcription factor E2F3
       K04453  MAX; Max protein
       K10500  ZBTB17, MIZ1; zinc finger and BTB domain-containing protein 17
       K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K10151  CCND2; G1/S-specific cyclin-D2
       K10152  CCND3; G1/S-specific cyclin-D3
       K02219  CKS1; cyclin-dependent kinase regulatory subunit CKS1
       K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
       K03347  CUL1, CDC53; cullin 1
       K03868  RBX1, ROC1; RING-box protein 1
       K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
       K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
       K06626  CCNE; G1/S-specific cyclin-E1
       K06618  RB1; retinoblastoma-associated protein
       K04402  GADD45; growth arrest and DNA-damage-inducible protein
       K02159  BAX; apoptosis regulator BAX
       K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
       K10140  DDB2; DNA damage-binding protein 2
       K03511  POLK; DNA polymerase kappa [EC:2.7.7.7]
       K11126  TERT, EST2; telomerase reverse transcriptase [EC:2.7.7.49]
       K22183  TERC; telomerase RNA component
       K09455  MITF; microphthalmia-associated transcription factor
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
       K04501  SMAD4; mothers against decapentaplegic homolog 4
       K04462  EVI1; ecotropic virus integration site 1 protein
       K04496  CTBP; C-terminal binding protein
       K06067  HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
       K08734  MLH1; DNA mismatch repair protein MLH1
       K08735  MSH2; DNA mismatch repair protein MSH2
       K08736  MSH3; DNA mismatch repair protein MSH3
       K08737  MSH6; DNA mismatch repair protein MSH6
       K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
       K04482  RAD51; DNA repair protein RAD51
       K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K04726  BID; BH3 interacting domain death agonist
       K10131  PMAIP1, NOXA; phorbol-12-myristate-13-acetate-induced protein 1
       K10132  BBC3, PUMA; Bcl-2-binding component 3
       K16341  BCL2L11, BIM; Bcl-2-like protein 11
       K08738  CYC; cytochrome c
       K02084  APAF1; apoptotic protease-activating factor
       K04397  CASP7; caspase 7 [EC:3.4.22.60]
       K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
       K05638  NFE2L2, NRF2; nuclear factor erythroid 2-related factor 2
       K00510  HMOX1; heme oxygenase 1 [EC:1.14.14.18]
       K00355  NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]
       K00799  GST, gst; glutathione S-transferase [EC:2.5.1.18]
       K22182  TXNRD; thioredoxin reductase (NADPH) [EC:1.8.1.9]
       K03871  VHL; von Hippel-Lindau disease tumor supressor
       K03872  TCEB1; transcription elongation factor B, polypeptide 1
       K03873  TCEB2; transcription elongation factor B, polypeptide 2
       K03870  CUL2; cullin 2
       K09592  EGLN, HPH; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
       K01679  E4.2.1.2B, fumC; fumarate hydratase, class II [EC:4.2.1.2]
       K08268  HIF1A; hypoxia-inducible factor 1 alpha
       K09095  HIF2A, EPAS1; hypoxia-inducible factor 2 alpha
       K09097  ARNT; aryl hydrocarbon receptor nuclear translocator
       K15589  ARNT2; aryl hydrocarbon receptor nuclear translocator 2
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K07299  SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
       K06052  JAG1, CD339; jagged-1
       K21635  JAG2; jagged-2
       K06051  DLL; delta
       K02599  NOTCH1; Notch 1
       K20994  NOTCH2; Notch 2
       K20995  NOTCH3; Notch 3
       K20996  NOTCH4; Notch 4
       K06054  HES1; hairy and enhancer of split 1
       K06055  HES5; hairy and enhancer of split 5
       K09091  HEY; hairy and enhancer of split related with YRPW motif
       K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
       K11988  SHH; sonic hedgehog
       K06225  PTCH1; patched 1
       K06226  SMO; smoothened
       K18806  KIF7; kinesin family member 7
       K06229  SUFU; suppressor of fused
       K16797  GLI1; zinc finger protein GLI1
       K16798  GLI2; zinc finger protein GLI2
       K06230  GLI3; zinc finger protein GLI3
       K21283  BMP2; bone morphogenetic protein 2
       K04662  BMP4; bone morphogenetic protein 4
       K06231  HHIP; hedgehog interacting protein
       K11101  PTCH2; patched 2
       K08557  AR, NR3C4; androgen receptor
       K04079  HSP90A, htpG; molecular chaperone HtpG
       K09487  HSP90B, TRA1; heat shock protein 90kDa beta
       K01351  KLK3; semenogelase [EC:3.4.21.77]
     05230 Central carbon metabolism in cancer [PATH:ko05230]
     05231 Choline metabolism in cancer [PATH:ko05231]
     05202 Transcriptional misregulation in cancers [PATH:ko05202]
     05206 MicroRNAs in cancer [PATH:ko05206]
     05205 Proteoglycans in cancer [PATH:ko05205]
     05204 Chemical carcinogenesis [PATH:ko05204]
       K07408  CYP1A1; cytochrome P450 family 1 subfamily A polypeptide 1 [EC:1.14.14.1]
       K17689  CYP3A4; cytochrome P450 family 3 subfamily A polypeptide 4 [EC:1.14.13.32 1.14.13.67 1.14.13.97 1.14.13.157 1.14.13.-]
       K17690  CYP3A5; cytochrome P450 family 3 subfamily A polypeptide 5 [EC:1.14.14.1]
       K17691  CYP3A7; cytochrome P450 family 3 subfamily A polypeptide 7 [EC:1.14.14.1]
       K17692  CYP3A43; cytochrome P450 family 3 subfamily A polypeptide 43 [EC:1.14.14.1]
       K07424  CYP3A; cytochrome P450 family 3 subfamily A [EC:1.14.14.1]
       K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
       K00622  nat; arylamine N-acetyltransferase [EC:2.3.1.5]
       K07409  CYP1A2; cytochrome P450 family 1 subfamily A polypeptide 2 [EC:1.14.14.1]
       K01014  SULT1A; aryl sulfotransferase [EC:2.8.2.1]
       K07410  CYP1B1; cytochrome P450 family 1 subfamily B polypeptide 1 [EC:1.14.14.1]
       K17718  CYP2C8; cytochrome P450 family 2 subfamily C polypeptide 8 [EC:1.14.14.1]
       K17719  CYP2C9; cytochrome P450 family 2 subfamily C polypeptide 9 [EC:1.14.13.48 1.14.13.49 1.14.13.80 1.14.13.-]
       K17720  CYP2C18; cytochrome P450 family 2 subfamily C polypeptide 18 [EC:1.14.14.1]
       K17721  CYP2C19; cytochrome P450 family 2 subfamily C polypeptide 19 [EC:1.14.13.48 1.14.13.49 1.14.13.80 1.14.13.-]
       K07413  CYP2C; cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
       K01253  EPHX1; microsomal epoxide hydrolase [EC:3.3.2.9]
       K09097  ARNT; aryl hydrocarbon receptor nuclear translocator
       K00799  GST, gst; glutathione S-transferase [EC:2.5.1.18]
       K13299  GSTK1; glutathione S-transferase kappa 1 [EC:2.5.1.18]
       K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]
       K11822  SULT2A1; bile-salt sulfotransferase [EC:2.8.2.14]
       K04809  CHRNA7; nicotinic acetylcholine receptor alpha-7
       K00079  CBR1; carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]
       K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]
       K17683  CYP2A6; cytochrome P450 family 2 subfamily A polypeptide 6 [EC:1.14.13.-]
       K17685  CYP2A13; cytochrome P450 family 2 subfamily A polypeptide 13 [EC:1.14.14.1]
       K00699  UGT; glucuronosyltransferase [EC:2.4.1.17]
       K07415  CYP2E1; cytochrome P450 family 2 subfamily E polypeptide 1 [EC:1.14.13.-]
       K07412  CYP2B; cytochrome P450 family 2 subfamily B [EC:1.14.14.1]
       K00129  E1.2.1.5; aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
       K13951  ADH1_7; alcohol dehydrogenase 1/7 [EC:1.1.1.1]
       K13980  ADH4; alcohol dehydrogenase 4 [EC:1.1.1.1]
       K13952  ADH6; alcohol dehydrogenase 6 [EC:1.1.1.1]
       K00121  frmA, ADH5, adhC; S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
       K00816  CCBL; kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase [EC:2.6.1.7 4.4.1.13 2.6.1.64]
     05203 Viral carcinogenesis [PATH:ko05203]
     05210 Colorectal cancer [PATH:ko05210]
     05212 Pancreatic cancer [PATH:ko05212]
     05225 Hepatocellular carcinoma [PATH:ko05225]
       K08774  TGFA; transforming growth factor, alpha
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K13769  IGF2; insulin-like growth factor 2
       K05087  IGF1R, CD221; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K02677  PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
       K19662  PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
       K19663  PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
       K04375  ELK1; ETS domain-containing protein Elk-1
       K06279  SHC1; SHC-transforming protein 1
       K17447  SHC2; SHC-transforming protein 2
       K17448  SHC3; SHC-transforming protein 3
       K17449  SHC4; SHC-transforming protein 4
       K04364  GRB2; growth factor receptor-binding protein 2
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
       K04688  RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
       K02158  BAD; Bcl-2-antagonist of cell death
       K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
       K04377  MYC; Myc proto-oncogene protein
       K06618  RB1; retinoblastoma-associated protein
       K17454  E2F1; transcription factor E2F1
       K09389  E2F2; transcription factor E2F2
       K06620  E2F3; transcription factor E2F3
       K11126  TERT, EST2; telomerase reverse transcriptase [EC:2.7.7.49]
       K22183  TERC; telomerase RNA component
       K04451  TP53, P53; tumor protein p53
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K04402  GADD45; growth arrest and DNA-damage-inducible protein
       K02159  BAX; apoptosis regulator BAX
       K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
       K10140  DDB2; DNA damage-binding protein 2
       K03511  POLK; DNA polymerase kappa [EC:2.7.7.7]
       K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K04503  CCND1; G1/S-specific cyclin-D1
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
       K04501  SMAD4; mothers against decapentaplegic homolog 4
       K03209  WNT1; wingless-type MMTV integration site family, member 1
       K00182  WNT2; wingless-type MMTV integration site family, member 2
       K00312  WNT3; wingless-type MMTV integration site family, member 3
       K00408  WNT4; wingless-type MMTV integration site family, member 4
       K00444  WNT5; wingless-type MMTV integration site family, member 5
       K00445  WNT6; wingless-type MMTV integration site family, member 6
       K00572  WNT7; wingless-type MMTV integration site family, member 7
       K00714  WNT8; wingless-type MMTV integration site family, member 8
       K01064  WNT9; wingless-type MMTV integration site family, member 9
       K01357  WNT10; wingless-type MMTV integration site family, member 10
       K01384  WNT11; wingless-type MMTV integration site family, member 11
       K01558  WNT16; wingless-type MMTV integration site family, member 16
       K02432  FZD1_7, fz; frizzled 1/7
       K02235  FZD2; frizzled 2
       K02329  FZD3; frizzled 3
       K02354  FZD4, fz4, CD344; frizzled 4
       K02375  FZD5_8, fz2; frizzled 5/8
       K02376  FZD6; frizzled 6
       K02842  FZD9_10, CD349_50; frizzled 9/10
       K03068  LRP5_6; low density lipoprotein receptor-related protein 5/6
       K02353  DVL; segment polarity protein dishevelled
       K03069  FRAT1; frequently rearranged in advanced T-cell lymphomas 1
       K03096  FRAT2; frequently rearranged in advanced T-cell lymphomas 2
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K02157  AXIN1; axin 1
       K04385  AXIN2; axin 2
       K02085  APC; adenomatosis polyposis coli protein
       K02105  CTNNB1; catenin beta 1
       K08957  CSNK1A; casein kinase 1, alpha [EC:2.7.11.1]
       K02620  TCF7; transcription factor 7
       K04490  TCF7L1; transcription factor 7-like 1
       K04491  TCF7L2; transcription factor 7-like 2
       K04492  LEF1; lymphoid enhancer-binding factor 1
       K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
       K05638  NFE2L2, NRF2; nuclear factor erythroid 2-related factor 2
       K00510  HMOX1; heme oxygenase 1 [EC:1.14.14.18]
       K00355  NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]
       K00799  GST, gst; glutathione S-transferase [EC:2.5.1.18]
       K22182  TXNRD; thioredoxin reductase (NADPH) [EC:1.8.1.9]
       K05460  HGF; hepatocyte growth factor
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
       K09593  GAB1; GRB2-associated-binding protein 1
       K05692  ACTB_G1; actin beta/gamma 1
       K11340  ACTL6A, INO80K; actin-like protein 6A
       K11652  ACTL6B; actin-like protein 6B
       K11650  SMARCD; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D
       K22197  BAF45A, PHF10; BRG1-associated factor 45A
       K22198  BAF45B_C, DPF1_3; BRG1-associated factor 45B/C
       K11653  ARID1; AT-rich interactive domain-containing protein 1
       K11651  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E, member 1
       K11648  SMARCB1, SNF5, INI1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
       K11649  SMARCC; SWI/SNF related-matrix-associated actin-dependent regulator of chromatin subfamily C
       K11647  SMARCA2_4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2/4 [EC:3.6.4.-]
       K11765  ARID2; AT-rich interactive domain-containing protein 2
       K11757  PBRM1, PB1; protein polybromo-1
       K11723  BRD7; bromodomain-containing protein 7
     05226 Gastric cancer [PATH:ko05226]
     05214 Glioma [PATH:ko05214]
     05216 Thyroid cancer [PATH:ko05216]
     05221 Acute myeloid leukemia [PATH:ko05221]
     05220 Chronic myeloid leukemia [PATH:ko05220]
     05217 Basal cell carcinoma [PATH:ko05217]
     05218 Melanoma [PATH:ko05218]
     05211 Renal cell carcinoma [PATH:ko05211]
     05219 Bladder cancer [PATH:ko05219]
     05215 Prostate cancer [PATH:ko05215]
     05213 Endometrial cancer [PATH:ko05213]
     05224 Breast cancer [PATH:ko05224]
     05222 Small cell lung cancer [PATH:ko05222]
     05223 Non-small cell lung cancer [PATH:ko05223]
 
   Immune diseases
 
   Neurodegenerative diseases
 
   Substance dependence
 
   Cardiovascular diseases
     05418 Fluid shear stress and atherosclerosis [PATH:ko05418]
       K04079  HSP90A, htpG; molecular chaperone HtpG
       K09487  HSP90B, TRA1; heat shock protein 90kDa beta
       K13242  NOS3; nitric-oxide synthase, endothelial [EC:1.14.13.39]
       K06278  CAV1; caveolin 1
       K12958  CAV2; caveolin 2
       K12959  CAV3; caveolin 3
       K02183  CALM; calmodulin
       K08107  GPC1; glypican 1
       K06257  SDC1, CD138; syndecan 1
       K16336  SDC2, CD362; syndecan 2
       K16338  SDC4; syndecan 4
       K04973  TRPV4; transient receptor potential cation channel subfamily V member 4
       K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
       K05638  NFE2L2, NRF2; nuclear factor erythroid 2-related factor 2
       K00510  HMOX1; heme oxygenase 1 [EC:1.14.14.18]
       K00799  GST, gst; glutathione S-transferase [EC:2.5.1.18]
       K00355  NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]
       K14381  SQSTM1; sequestosome 1
       K03671  trxA; thioredoxin 1
       K12336  NPPC; natriuretic peptide C
       K01940  argG, ASS1; argininosuccinate synthase [EC:6.3.4.5]
       K03907  THBD, CD141; thrombomodulin
       K01343  PLAT; tissue plasminogen activator [EC:3.4.21.68]
       K06533  CDH5, CD144; cadherin 5, type 2, VE-cadherin
       K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor [EC:2.7.10.1]
       K02105  CTNNB1; catenin beta 1
       K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
       K06471  PECAM1, CD31; platelet/endothelial cell adhesion molecule
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04463  MAP2K5, MEK5; mitogen-activated protein kinase kinase 5 [EC:2.7.12.2]
       K04464  MAPK7; mitogen-activated protein kinase 7 [EC:2.7.11.24]
       K09260  MEF2A; MADS-box transcription enhancer factor 2A
       K04454  MEF2C; MADS-box transcription enhancer factor 2C
       K17845  KLF2; krueppel-like factor 2
       K06476  ITGA2B, CD41; integrin alpha 2B
       K06487  ITGAV, CD51; integrin alpha V
       K06493  ITGB3, CD61; integrin beta 3
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
       K12791  ARHGEF2, GEF-H1; Rho guanine nucleotide exchange factor 2
       K04513  RHOA; Ras homolog gene family, member A
       K05692  ACTB_G1; actin beta/gamma 1
       K21278  DUSP1; dual specificity protein phosphatase 1 [EC:3.1.3.16 3.1.3.48]
       K16864  MIR10A; microRNA 10a
       K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
       K04386  IL1R1, CD121a; interleukin 1 receptor type I
       K04387  IL1R2, CD121b; interleukin 1 receptor type II
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
       K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
       K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K20607  MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
       K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04379  FOS; proto-oncogene protein c-fos
       K04448  JUN; transcription factor AP-1
       K01398  MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
       K01403  MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
       K01365  CTSL; cathepsin L [EC:3.4.22.15]
       K14624  CCL2, MCP1; C-C motif chemokine 2
       K06527  VCAM1, CD106; vascular cell adhesion molecule 1
       K06490  ICAM1, CD54; intercellular adhesion molecule 1
       K06494  SELE, CD62E; selectin, endothelial cell
       K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
       K04383  IL1A; interleukin 1 alpha
       K04519  IL1B; interleukin 1 beta
       K04687  IFNG; interferon gamma
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K16366  EDN1; endothelin-1
       K05448  VEGFA; vascular endothelial growth factor A
       K04662  BMP4; bone morphogenetic protein 4
       K04671  BMPR2; bone morphogenetic protein receptor type-2 [EC:2.7.11.30]
       K04670  ACVR2A; activin receptor type-2A [EC:2.7.11.30]
       K13596  ACVR2B; activin receptor type-2B [EC:2.7.11.30]
       K04675  ACVR1, ALK2; activin receptor type-1 [EC:2.7.11.30]
       K04673  BMPR1A, ALK3, CD292; bone morphogenetic protein receptor type-1A [EC:2.7.11.30]
       K13578  BMPR1B, ALK6, CDw293; bone morphogenetic protein receptor type-1B [EC:2.7.11.30]
       K08008  NOX1, MOX1; NADPH oxidase 1
       K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
       K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
       K08010  NCF2, P67PHOX; neutrophil cytosolic factor 2
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K18952  PRKCZ; atypical protein kinase C zeta type [EC:2.7.11.13]
       K16065  PIAS4; E3 SUMO-protein ligase PIAS4
       K04451  TP53, P53; tumor protein p53
       K12160  SUMO, SMT3; small ubiquitin-related modifier
       K02161  BCL2; apoptosis regulator Bcl-2
     05410 Hypertrophic cardiomyopathy (HCM) [PATH:ko05410]
     05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) [PATH:ko05412]
     05414 Dilated cardiomyopathy (DCM) [PATH:ko05414]
     05416 Viral myocarditis [PATH:ko05416]
 
   Endocrine and metabolic diseases
 
   Infectious diseases
 
   Drug resistance
     01501 beta-Lactam resistance [PATH:ko01501]
     01502 Vancomycin resistance [PATH:ko01502]
     01503 Cationic antimicrobial peptide (CAMP) resistance [PATH:ko01503]
     01504 Antimicrobial resistance genes [BR:ko01504]
     01521 EGFR tyrosine kinase inhibitor resistance [PATH:ko01521]
     01524 Platinum drug resistance [PATH:ko01524]
       K14686  SLC31A1, CTR1; solute carrier family 31 (copper transporter), member 1
       K17686  copA, ATP7; Cu+-exporting ATPase [EC:3.6.3.54]
       K00799  GST, gst; glutathione S-transferase [EC:2.5.1.18]
       K05666  ABCC2; ATP-binding cassette, subfamily C (CFTR/MRP), member 2
       K03509  POLH; DNA polymerase eta [EC:2.7.7.7]
       K02350  POLZ1, rev3; DNA polymerase zeta [EC:2.7.7.7]
       K08735  MSH2; DNA mismatch repair protein MSH2
       K08736  MSH3; DNA mismatch repair protein MSH3
       K08737  MSH6; DNA mismatch repair protein MSH6
       K08734  MLH1; DNA mismatch repair protein MLH1
       K10847  XPA; DNA-repair protein complementing XP-A cells
       K10849  ERCC1; DNA excision repair protein ERCC-1
       K03164  TOP2; DNA topoisomerase II [EC:5.99.1.3]
       K10605  BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
       K04728  ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
       K04451  TP53, P53; tumor protein p53
       K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
       K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
       K02159  BAX; apoptosis regulator BAX
       K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
       K10131  PMAIP1, NOXA; phorbol-12-myristate-13-acetate-induced protein 1
       K10132  BBC3, PUMA; Bcl-2-binding component 3
       K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K04726  BID; BH3 interacting domain death agonist
       K16060  BIRC2_3; baculoviral IAP repeat-containing protein 2/3
       K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
       K08731  BIRC5; baculoviral IAP repeat-containing protein 5
       K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K02158  BAD; Bcl-2-antagonist of cell death
       K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
       K02161  BCL2; apoptosis regulator Bcl-2
       K08738  CYC; cytochrome c
       K02084  APAF1; apoptotic protease-activating factor
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
     01523 Antifolate resistance [PATH:ko01523]
     01522 Endocrine resistance [PATH:ko01522]

[ KO | BRITE | KEGG2 | KEGG ]
Last updated: November 18, 2017