KEGG Orthology (KO)

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 Metabolism
 
   Overview
 
   Carbohydrate metabolism
 
   Energy metabolism
 
   Lipid metabolism
 
   Nucleotide metabolism
 
   Amino acid metabolism
 
   Metabolism of other amino acids
     00410 beta-Alanine metabolism [PATH:ko00410]
     00430 Taurine and hypotaurine metabolism [PATH:ko00430]
     00440 Phosphonate and phosphinate metabolism [PATH:ko00440]
     00450 Selenocompound metabolism [PATH:ko00450]
     00460 Cyanoamino acid metabolism [PATH:ko00460]
     00471 D-Glutamine and D-glutamate metabolism [PATH:ko00471]
     00472 D-Arginine and D-ornithine metabolism [PATH:ko00472]
     00473 D-Alanine metabolism [PATH:ko00473]
     00480 Glutathione metabolism [PATH:ko00480]
       K00681  ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
       K18592  GGT1_5; gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase [EC:2.3.2.2 3.4.19.13 3.4.19.14]
       K00682  GGCT; gamma-glutamylcyclotransferase [EC:2.3.2.4]
       K01469  OPLAH, OXP1, oplAH; 5-oxoprolinase (ATP-hydrolysing) [EC:3.5.2.9]
       K11204  GCLC; glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]
       K11205  GCLM; glutamate--cysteine ligase regulatory subunit
       K01919  gshA; glutamate--cysteine ligase [EC:6.3.2.2]
       K01920  gshB, GSS; glutathione synthase [EC:6.3.2.3]
       K11142  LAP3; cytosol aminopeptidase [EC:3.4.11.1 3.4.11.5]
       K01255  CARP, pepA; leucyl aminopeptidase [EC:3.4.11.1]
       K07751  pepB; PepB aminopeptidase [EC:3.4.11.23]
       K11140  ANPEP; aminopeptidase N [EC:3.4.11.2]
       K01256  pepN; aminopeptidase N [EC:3.4.11.2]
       K01270  pepD; dipeptidase D [EC:3.4.13.-]
       K15428  DUG1; Cys-Gly metallodipeptidase DUG1 [EC:3.4.13.-]
       K00799  GST, gst; glutathione S-transferase [EC:2.5.1.18]
       K13299  GSTK1; glutathione S-transferase kappa 1 [EC:2.5.1.18]
       K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]
       K00383  GSR, gor; glutathione reductase (NADPH) [EC:1.8.1.7]
       K00031  IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]
       K00032  E1.1.1.43; phosphogluconate 2-dehydrogenase [EC:1.1.1.43]
       K00033  PGD, gnd, gntZ; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]
       K00036  G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
       K05360  TXNDC12; protein-disulfide reductase (glutathione) [EC:1.8.4.2]
       K00432  gpx; glutathione peroxidase [EC:1.11.1.9]
       K05361  GPX4; phospholipid-hydroperoxide glutathione peroxidase [EC:1.11.1.12]
       K00310  SE; pyrimidodiazepine synthase [EC:1.5.4.1]
       K01581  E4.1.1.17, ODC1, speC, speF; ornithine decarboxylase [EC:4.1.1.17]
       K00797  speE, SRM; spermidine synthase [EC:2.5.1.16]
       K01917  E6.3.1.8; glutathionylspermidine synthase [EC:6.3.1.8]
       K01460  gsp; glutathionylspermidine amidase/synthetase [EC:3.5.1.78 6.3.1.8]
       K00802  SMS; spermine synthase [EC:2.5.1.22]
       K01833  TRYS; trypanothione synthetase/amidase [EC:6.3.1.9 3.5.1.-]
       K04283  TRYR; trypanothione-disulfide reductase [EC:1.8.1.12]
       K00434  E1.11.1.11; L-ascorbate peroxidase [EC:1.11.1.11]
       K11185  TRYP; cytosolic tryparedoxin peroxidase, trypanosomatid typical 2-Cys peroxiredoxin [EC:1.11.1.15]
       K11186  MTRYP; mitochondrial tryparedoxin peroxidase, trypanosomatid typical 2-Cys peroxiredoxin [EC:1.11.1.15]
       K11207  TDPX; glutathione peroxidase-type tryparedoxin peroxidase [EC:1.11.1.-]
       K10807  RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
       K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
 
   Glycan biosynthesis and metabolism
 
   Metabolism of cofactors and vitamins
 
   Metabolism of terpenoids and polyketides
 
   Biosynthesis of other secondary metabolites
 
   Xenobiotics biodegradation and metabolism
     00362 Benzoate degradation [PATH:ko00362]
     00627 Aminobenzoate degradation [PATH:ko00627]
     00364 Fluorobenzoate degradation [PATH:ko00364]
     00625 Chloroalkane and chloroalkene degradation [PATH:ko00625]
     00361 Chlorocyclohexane and chlorobenzene degradation [PATH:ko00361]
     00623 Toluene degradation [PATH:ko00623]
     00622 Xylene degradation [PATH:ko00622]
     00633 Nitrotoluene degradation [PATH:ko00633]
     00642 Ethylbenzene degradation [PATH:ko00642]
     00643 Styrene degradation [PATH:ko00643]
     00791 Atrazine degradation [PATH:ko00791]
     00930 Caprolactam degradation [PATH:ko00930]
     00351 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation [PATH:ko00351]
     00363 Bisphenol degradation [PATH:ko00363]
     00621 Dioxin degradation [PATH:ko00621]
     00626 Naphthalene degradation [PATH:ko00626]
     00624 Polycyclic aromatic hydrocarbon degradation [PATH:ko00624]
     00365 Furfural degradation [PATH:ko00365]
     00984 Steroid degradation [PATH:ko00984]
     00980 Metabolism of xenobiotics by cytochrome P450 [PATH:ko00980]
       K07408  CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1 [EC:1.14.14.1]
       K17719  CYP2C9; cytochrome P450, family 2, subfamily C, polypeptide 9 [EC:1.14.13.48 1.14.13.49 1.14.13.80 1.14.13.-]
       K17689  CYP3A4; cytochrome P450, family 3, subfamily A, polypeptide 4 [EC:1.14.13.32 1.14.13.67 1.14.13.97 1.14.13.157 1.14.13.-]
       K07410  CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1 [EC:1.14.14.1]
       K00799  GST, gst; glutathione S-transferase [EC:2.5.1.18]
       K13299  GSTK1; glutathione S-transferase kappa 1 [EC:2.5.1.18]
       K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]
       K01253  EPHX1; microsomal epoxide hydrolase [EC:3.3.2.9]
       K17709  CYP2B6; cytochrome P450, family 2, subfamily B, polypeptide 6 [EC:1.14.13.-]
       K11822  SULT2A1; bile-salt sulfotransferase [EC:2.8.2.14]
       K07409  CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2 [EC:1.14.14.1]
       K17683  CYP2A6; cytochrome P450, family 2, subfamily A, polypeptide 6 [EC:1.14.13.-]
       K07415  CYP2E1; cytochrome P450, family 2, subfamily E, polypeptide 1 [EC:1.14.13.-]
       K07416  CYP2F; cytochrome P450, family 2, subfamily F [EC:1.14.14.1]
       K07420  CYP2S1; cytochrome P450, family 2, subfamily S, polypeptide 1 [EC:1.14.14.1]
       K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase [EC:1.1.1.149 1.1.1.357 1.3.1.20]
       K00078  DHDH; dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP) [EC:1.3.1.20 1.1.1.179]
       K17685  CYP2A13; cytochrome P450, family 2, subfamily A, polypeptide 13 [EC:1.14.14.1]
       K17712  CYP2D6; cytochrome P450, family 2, subfamily D, polypeptide 6 [EC:1.14.14.1]
       K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]
       K00079  CBR1; carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]
       K00081  CBR2; carbonyl reductase 2 [EC:1.1.1.184]
       K00084  CBR3; carbonyl reductase 3 [EC:1.1.1.184]
       K00699  UGT; glucuronosyltransferase [EC:2.4.1.17]
       K17690  CYP3A5; cytochrome P450, family 3, subfamily A, polypeptide 5 [EC:1.14.14.1]
       K15303  AKR7; aflatoxin B1 aldehyde reductase
       K00129  E1.2.1.5; aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
       K13951  ADH1_7; alcohol dehydrogenase 1/7 [EC:1.1.1.1]
       K13980  ADH4; alcohol dehydrogenase 4 [EC:1.1.1.1]
       K00121  frmA, ADH5, adhC; S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
       K13952  ADH6; alcohol dehydrogenase 6 [EC:1.1.1.1]
       K13953  adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
       K00001  E1.1.1.1, adh; alcohol dehydrogenase [EC:1.1.1.1]
     00982 Drug metabolism - cytochrome P450 [PATH:ko00982]
       K17712  CYP2D6; cytochrome P450, family 2, subfamily D, polypeptide 6 [EC:1.14.14.1]
       K17719  CYP2C9; cytochrome P450, family 2, subfamily C, polypeptide 9 [EC:1.14.13.48 1.14.13.49 1.14.13.80 1.14.13.-]
       K17689  CYP3A4; cytochrome P450, family 3, subfamily A, polypeptide 4 [EC:1.14.13.32 1.14.13.67 1.14.13.97 1.14.13.157 1.14.13.-]
       K00485  FMO; dimethylaniline monooxygenase (N-oxide forming) [EC:1.14.13.8]
       K17721  CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19 [EC:1.14.13.48 1.14.13.49 1.14.13.80 1.14.13.-]
       K17709  CYP2B6; cytochrome P450, family 2, subfamily B, polypeptide 6 [EC:1.14.13.-]
       K17690  CYP3A5; cytochrome P450, family 3, subfamily A, polypeptide 5 [EC:1.14.14.1]
       K00799  GST, gst; glutathione S-transferase [EC:2.5.1.18]
       K13299  GSTK1; glutathione S-transferase kappa 1 [EC:2.5.1.18]
       K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]
       K13951  ADH1_7; alcohol dehydrogenase 1/7 [EC:1.1.1.1]
       K13980  ADH4; alcohol dehydrogenase 4 [EC:1.1.1.1]
       K00121  frmA, ADH5, adhC; S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
       K13952  ADH6; alcohol dehydrogenase 6 [EC:1.1.1.1]
       K13953  adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
       K00001  E1.1.1.1, adh; alcohol dehydrogenase [EC:1.1.1.1]
       K00129  E1.2.1.5; aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
       K00274  MAO, aofH; monoamine oxidase [EC:1.4.3.4]
       K00157  AOX; aldehyde oxidase [EC:1.2.3.1]
       K00699  UGT; glucuronosyltransferase [EC:2.4.1.17]
       K07409  CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2 [EC:1.14.14.1]
       K07415  CYP2E1; cytochrome P450, family 2, subfamily E, polypeptide 1 [EC:1.14.13.-]
       K17718  CYP2C8; cytochrome P450, family 2, subfamily C, polypeptide 8 [EC:1.14.14.1]
       K17683  CYP2A6; cytochrome P450, family 2, subfamily A, polypeptide 6 [EC:1.14.13.-]
     00983 Drug metabolism - other enzymes [PATH:ko00983]
 
   Enzyme families
 
 Genetic Information Processing
 
 Environmental Information Processing
 
 Cellular Processes
 
 Organismal Systems
 
 Human Diseases
 
   Cancers
     05200 Pathways in cancer [PATH:ko05200]
     05230 Central carbon metabolism in cancer [PATH:ko05230]
     05231 Choline metabolism in cancer [PATH:ko05231]
     05202 Transcriptional misregulation in cancers [PATH:ko05202]
     05206 MicroRNAs in cancer [PATH:ko05206]
     05205 Proteoglycans in cancer [PATH:ko05205]
     05204 Chemical carcinogenesis [PATH:ko05204]
       K07408  CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1 [EC:1.14.14.1]
       K17689  CYP3A4; cytochrome P450, family 3, subfamily A, polypeptide 4 [EC:1.14.13.32 1.14.13.67 1.14.13.97 1.14.13.157 1.14.13.-]
       K17690  CYP3A5; cytochrome P450, family 3, subfamily A, polypeptide 5 [EC:1.14.14.1]
       K17691  CYP3A7; cytochrome P450, family 3, subfamily A, polypeptide 7 [EC:1.14.14.1]
       K17692  CYP3A43; cytochrome P450, family 3, subfamily A, polypeptide 43 [EC:1.14.14.1]
       K07424  CYP3A; cytochrome P450, family 3, subfamily A [EC:1.14.14.1]
       K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
       K00622  nat; arylamine N-acetyltransferase [EC:2.3.1.5]
       K07409  CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2 [EC:1.14.14.1]
       K01014  SULT1A; aryl sulfotransferase [EC:2.8.2.1]
       K07410  CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1 [EC:1.14.14.1]
       K17718  CYP2C8; cytochrome P450, family 2, subfamily C, polypeptide 8 [EC:1.14.14.1]
       K17719  CYP2C9; cytochrome P450, family 2, subfamily C, polypeptide 9 [EC:1.14.13.48 1.14.13.49 1.14.13.80 1.14.13.-]
       K17720  CYP2C18; cytochrome P450, family 2, subfamily C, polypeptide 18 [EC:1.14.14.1]
       K17721  CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19 [EC:1.14.13.48 1.14.13.49 1.14.13.80 1.14.13.-]
       K07413  CYP2C; cytochrome P450, family 2, subfamily C [EC:1.14.14.1]
       K01253  EPHX1; microsomal epoxide hydrolase [EC:3.3.2.9]
       K09097  ARNT; aryl hydrocarbon receptor nuclear translocator
       K00799  GST, gst; glutathione S-transferase [EC:2.5.1.18]
       K13299  GSTK1; glutathione S-transferase kappa 1 [EC:2.5.1.18]
       K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]
       K11822  SULT2A1; bile-salt sulfotransferase [EC:2.8.2.14]
       K04809  CHRNA7; nicotinic acetylcholine receptor alpha-7
       K00079  CBR1; carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]
       K15680  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]
       K17683  CYP2A6; cytochrome P450, family 2, subfamily A, polypeptide 6 [EC:1.14.13.-]
       K17685  CYP2A13; cytochrome P450, family 2, subfamily A, polypeptide 13 [EC:1.14.14.1]
       K00699  UGT; glucuronosyltransferase [EC:2.4.1.17]
       K07415  CYP2E1; cytochrome P450, family 2, subfamily E, polypeptide 1 [EC:1.14.13.-]
       K07412  CYP2B; cytochrome P450, family 2, subfamily B [EC:1.14.14.1]
       K00129  E1.2.1.5; aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
       K13951  ADH1_7; alcohol dehydrogenase 1/7 [EC:1.1.1.1]
       K13980  ADH4; alcohol dehydrogenase 4 [EC:1.1.1.1]
       K13952  ADH6; alcohol dehydrogenase 6 [EC:1.1.1.1]
       K00121  frmA, ADH5, adhC; S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
       K00816  CCBL; kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase [EC:2.6.1.7 4.4.1.13 2.6.1.64]
     05203 Viral carcinogenesis [PATH:ko05203]
     05210 Colorectal cancer [PATH:ko05210]
     05212 Pancreatic cancer [PATH:ko05212]
     05214 Glioma [PATH:ko05214]
     05216 Thyroid cancer [PATH:ko05216]
     05221 Acute myeloid leukemia [PATH:ko05221]
     05220 Chronic myeloid leukemia [PATH:ko05220]
     05217 Basal cell carcinoma [PATH:ko05217]
     05218 Melanoma [PATH:ko05218]
     05211 Renal cell carcinoma [PATH:ko05211]
     05219 Bladder cancer [PATH:ko05219]
     05215 Prostate cancer [PATH:ko05215]
     05213 Endometrial cancer [PATH:ko05213]
     05222 Small cell lung cancer [PATH:ko05222]
     05223 Non-small cell lung cancer [PATH:ko05223]
 
   Immune diseases
 
   Neurodegenerative diseases
 
   Substance dependence
 
   Cardiovascular diseases
 
   Endocrine and metabolic diseases
 
   Infectious diseases
 
   Antimicrobial resistance
 
   Antineoplastic resistance
     01521 EGFR tyrosine kinase inhibitor resistance [PATH:ko01521]
     01524 Platinum drug resistance [PATH:ko01524]
       K14686  SLC31A1, CTR1; solute carrier family 31 (copper transporter), member 1
       K17686  copA, ATP7; Cu+-exporting ATPase [EC:3.6.3.54]
       K00799  GST, gst; glutathione S-transferase [EC:2.5.1.18]
       K05666  ABCC2; ATP-binding cassette, subfamily C (CFTR/MRP), member 2
       K03509  POLH; DNA polymerase eta [EC:2.7.7.7]
       K02350  POLZ1, rev3; DNA polymerase zeta [EC:2.7.7.7]
       K08735  MSH2; DNA mismatch repair protein MSH2
       K08736  MSH3; DNA mismatch repair protein MSH3
       K08737  MSH6; DNA mismatch repair protein MSH6
       K08734  MLH1; DNA mismatch repair protein MLH1
       K10847  XPA; DNA-repair protein complementing XP-A cells
       K10849  ERCC1; DNA excision repair protein ERCC-1
       K03164  TOP2; DNA topoisomerase II [EC:5.99.1.3]
       K10605  BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
       K04728  ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
       K04451  TP53, P53; tumor protein p53
       K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
       K04390  TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
       K02159  BAX; apoptosis regulator BAX
       K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
       K10131  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
       K10132  BBC3, PUMA; Bcl-2-binding component 3
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K04726  BID; BH3 interacting domain death agonist
       K16060  BIRC2_3; baculoviral IAP repeat-containing protein 2/3
       K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
       K08731  BIRC5; baculoviral IAP repeat-containing protein 5
       K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K02158  BAD; Bcl-2-antagonist of cell death
       K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
       K02161  BCL2; apoptosis regulator Bcl-2
       K08738  CYC; cytochrome c
       K02084  APAF1; apoptotic protease-activating factor
       K04399  CASP9; caspase 9 [EC:3.4.22.62]

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Last updated: July 23, 2016