KEGG Orthology (KO)

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 Metabolism
 
 Genetic Information Processing
 
 Environmental Information Processing
 
 Cellular Processes
 
 Organismal Systems
 
   Immune system
 
   Endocrine system
     04911 Insulin secretion [PATH:ko04911]
     04910 Insulin signaling pathway [PATH:ko04910]
     04922 Glucagon signaling pathway [PATH:ko04922]
     04923 Regulation of lipolysis in adipocyte [PATH:ko04923]
     04920 Adipocytokine signaling pathway [PATH:ko04920]
     03320 PPAR signaling pathway [PATH:ko03320]
     04912 GnRH signaling pathway [PATH:ko04912]
     04913 Ovarian Steroidogenesis [PATH:ko04913]
     04915 Estrogen signaling pathway [PATH:ko04915]
     04914 Progesterone-mediated oocyte maturation [PATH:ko04914]
     04917 Prolactin signaling pathway [PATH:ko04917]
     04921 Oxytocin signaling pathway [PATH:ko04921]
     04918 Thyroid hormone synthesis [PATH:ko04918]
     04919 Thyroid hormone signaling pathway [PATH:ko04919]
     04916 Melanogenesis [PATH:ko04916]
     04924 Renin secretion [PATH:ko04924]
       K04141  ADRB1; adrenergic receptor beta-1
       K04142  ADRB2; adrenergic receptor beta-2
       K04143  ADRB3; adrenergic receptor beta-3
       K05262  ADCYAP; adenylate cyclase activating polypeptide
       K04587  ADCYAP1R1, PACAPRI; pituitary adenylate cyclase-activating polypeptide type I receptor
       K09864  AQP1; aquaporin-1
       K04259  PTGER2; prostaglandin E receptor 2
       K04261  PTGER4; prostaglandin E receptor 4
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04936  KCNMA1; potassium large conductance calcium-activated channel subfamily M alpha member 1
       K13755  PDE1; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]
       K19021  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [EC:3.1.4.17]
       K13296  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [EC:3.1.4.17]
       K01380  REN; renin [EC:3.4.23.15]
       K04265  ADORA1; adenosine A1 receptor
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K16056  ORAI1; calcium release-activated calcium channel protein 1
       K05027  CLCA1; calcium-activated chloride channel regulator 1
       K05028  CLCA2; calcium-activated chloride channel regulator 2
       K05030  CLCA3_4; calcium-activated chloride channel regulator 3/4
       K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
       K04851  CACNA1D; voltage-dependent calcium channel L type alpha-1D
       K04853  CACNA1F; voltage-dependent calcium channel L type alpha-1F
       K04857  CACNA1S; voltage-dependent calcium channel L type alpha-1S
       K04996  KCNJ2; potassium inwardly-rectifying channel subfamily J member 2
       K04197  EDNRA; endothelin receptor type A
       K04166  AGTR1; angiotensin II receptor type 1
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K02183  CALM; calmodulin
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K12318  GUCY1A; guanylate cyclase soluble subunit alpha [EC:4.6.1.2]
       K12319  GUCY1B; guanylate cyclase soluble subunit beta [EC:4.6.1.2]
       K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A [EC:4.6.1.2]
       K19477  PRKG2; cGMP-dependent protein kinase 2 [EC:2.7.11.12]
       K01363  CTSB; cathepsin B [EC:3.4.22.1]
       K09821  AGT; angiotensinogen
       K01283  ACE, CD143; peptidyl-dipeptidase A [EC:3.4.15.1]
     04614 Renin-angiotensin system [PATH:ko04614]
       K09821  AGT; angiotensinogen
       K01380  REN; renin [EC:3.4.23.15]
       K01283  ACE, CD143; peptidyl-dipeptidase A [EC:3.4.15.1]
       K01329  CMA1; chymase [EC:3.4.21.39]
       K01319  CTSG; cathepsin G [EC:3.4.21.20]
       K01325  KLK1_2; tissue kallikrein [EC:3.4.21.35]
       K11141  ENPEP, CD249; glutamyl aminopeptidase [EC:3.4.11.7]
       K11140  ANPEP, CD13; aminopeptidase N [EC:3.4.11.2]
       K01322  PREP; prolyl oligopeptidase [EC:3.4.21.26]
       K09708  ACE2, ACEH; angiotensin-converting enzyme 2 [EC:3.4.17.23]
       K13289  CTSA, CPY; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
       K08780  CPA3; carboxypeptidase A3 [EC:3.4.17.1]
       K01389  MME, CD10; neprilysin [EC:3.4.24.11]
       K01392  THOP1; thimet oligopeptidase [EC:3.4.24.15]
       K01393  NLN; neurolysin [EC:3.4.24.16]
       K01285  PRCP; lysosomal Pro-X carboxypeptidase [EC:3.4.16.2]
       K04303  MAS1; MAS1 oncogene
       K08392  MRGPRD; Mas-related G protein-coupled receptor member D
       K04166  AGTR1; angiotensin II receptor type 1
       K04167  AGTR2; angiotensin II receptor type 2
       K01257  LNPEP; cystinyl aminopeptidase [EC:3.4.11.3]
       K19514  ATP6AP2, PRR; renin receptor
     04925 Aldosterone synthesis and secretion [PATH:ko04925]
 
   Circulatory system
 
   Digestive system
 
   Excretory system
 
   Nervous system
 
   Sensory system
 
   Development
 
   Aging
 
   Environmental adaptation
 
 Human Diseases
 
   Cancers
 
   Immune diseases
 
   Neurodegenerative diseases
 
   Substance dependence
 
   Cardiovascular diseases
     05418 Fluid shear stress and atherosclerosis [PATH:ko05418]
     05410 Hypertrophic cardiomyopathy (HCM) [PATH:ko05410]
       K06480  ITGA1, CD49a; integrin alpha 1
       K06481  ITGA2, CD49b; integrin alpha 2
       K06476  ITGA2B, CD41; integrin alpha 2B
       K06482  ITGA3, CD49c; integrin alpha 3
       K06483  ITGA4, CD49d; integrin alpha 4
       K06484  ITGA5, CD49e; integrin alpha 5
       K06485  ITGA6, CD49f; integrin alpha 6
       K06583  ITGA7; integrin alpha 7
       K06584  ITGA8; integrin alpha 8
       K06585  ITGA9; integrin alpha 9
       K06586  ITGA10; integrin alpha 10
       K06587  ITGA11; integrin alpha 11
       K06487  ITGAV, CD51; integrin alpha V
       K05719  ITGB1, CD29; integrin beta 1
       K06493  ITGB3, CD61; integrin beta 3
       K06525  ITGB4, CD104; integrin beta 4
       K06588  ITGB5; integrin beta 5
       K06589  ITGB6; integrin beta 6
       K06590  ITGB7; integrin beta 7
       K06591  ITGB8; integrin beta 8
       K12563  SGCD; delta-sarcoglycan
       K12564  SGCG; gamma-sarcoglycan
       K12565  SGCA; alpha-sarcoglycan
       K12566  SGCB; beta-sarcoglycan
       K06265  DAG1; dystroglycan 1
       K07610  DES; desmin
       K10366  DMD; dystrophin
       K05692  ACTB_G1; actin beta/gamma 1
       K12567  TTN; titin [EC:2.7.11.1]
       K12045  TNNT2; troponin T, cardiac muscle
       K05865  TNNC1; troponin C, slow skeletal and cardiac muscles
       K12044  TNNI3; troponin I, cardiac muscle
       K12314  ACTC1; actin, alpha cardiac muscle
       K10373  TPM1; tropomyosin 1
       K10374  TPM2; tropomyosin 2
       K09290  TPM3; tropomyosin 3
       K10375  TPM4; tropomyosin 4
       K12568  MYBPC3; myosin-binding protein C, cardiac-type
       K12749  MYL3; myosin light chain 3
       K10351  MYL2; myosin regulatory light chain 2
       K12569  EMD; emerin
       K12641  LMNA; lamin A/C
       K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
       K04851  CACNA1D; voltage-dependent calcium channel L type alpha-1D
       K04853  CACNA1F; voltage-dependent calcium channel L type alpha-1F
       K04857  CACNA1S; voltage-dependent calcium channel L type alpha-1S
       K04862  CACNB1; voltage-dependent calcium channel beta-1
       K04863  CACNB2; voltage-dependent calcium channel beta-2
       K04864  CACNB3; voltage-dependent calcium channel beta-3
       K04865  CACNB4; voltage-dependent calcium channel beta-4
       K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
       K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
       K04860  CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
       K04861  CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
       K04866  CACNG1; voltage-dependent calcium channel gamma-1
       K04867  CACNG2; voltage-dependent calcium channel gamma-2
       K04868  CACNG3; voltage-dependent calcium channel gamma-3
       K04869  CACNG4; voltage-dependent calcium channel gamma-4
       K04870  CACNG5; voltage-dependent calcium channel gamma-5
       K04871  CACNG6; voltage-dependent calcium channel gamma-6
       K04872  CACNG7; voltage-dependent calcium channel gamma-7
       K04873  CACNG8; voltage-dependent calcium channel gamma-8
       K04962  RYR2; ryanodine receptor 2
       K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
       K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
       K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
       K01283  ACE, CD143; peptidyl-dipeptidase A [EC:3.4.15.1]
       K05459  IGF1; insulin-like growth factor 1
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
       K05405  IL6; interleukin 6
       K16366  EDN1; endothelin-1
       K09821  AGT; angiotensinogen
     05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) [PATH:ko05412]
     05414 Dilated cardiomyopathy (DCM) [PATH:ko05414]
     05416 Viral myocarditis [PATH:ko05416]
 
   Endocrine and metabolic diseases
 
   Infectious diseases
     05110 Vibrio cholerae infection [PATH:ko05110]
     05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
     05130 Pathogenic Escherichia coli infection [PATH:ko05130]
     05132 Salmonella infection [PATH:ko05132]
     05131 Shigellosis [PATH:ko05131]
     05133 Pertussis [PATH:ko05133]
     05134 Legionellosis [PATH:ko05134]
     05150 Staphylococcus aureus infection [PATH:ko05150]
     05152 Tuberculosis [PATH:ko05152]
     05100 Bacterial invasion of epithelial cells [PATH:ko05100]
     05166 HTLV-I infection [PATH:ko05166]
     05162 Measles [PATH:ko05162]
     05164 Influenza A [PATH:ko05164]
     05161 Hepatitis B [PATH:ko05161]
     05160 Hepatitis C [PATH:ko05160]
     05168 Herpes simplex infection [PATH:ko05168]
     05169 Epstein-Barr virus infection [PATH:ko05169]
     05146 Amoebiasis [PATH:ko05146]
     05144 Malaria [PATH:ko05144]
     05145 Toxoplasmosis [PATH:ko05145]
     05140 Leishmaniasis [PATH:ko05140]
     05142 Chagas disease (American trypanosomiasis) [PATH:ko05142]
       K10160  TLR4, CD284; toll-like receptor 4
       K05842  TRIF; toll-like receptor adapter molecule 1
       K13729  TCAC2, TC52; thiol-dependent reductase 1
       K10159  TLR2, CD282; toll-like receptor 2
       K10169  TLR6, CD286; toll-like receptor 6
       K10161  TLR9, CD289; toll-like receptor 9
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K04730  IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K03175  TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
       K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04379  FOS; proto-oncogene protein c-fos
       K04448  JUN; transcription factor AP-1
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K05415  IFNB; interferon beta
       K12499  CCL5; C-C motif chemokine 5
       K14624  CCL2, MCP1; C-C motif chemokine 2
       K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
       K05406  IL12A; interleukin 12A
       K05425  IL12B; interleukin 12B
       K05405  IL6; interleukin 6
       K10030  IL8, CXCL8; interleukin 8
       K05408  CCL3; C-C motif chemokine 3
       K04519  IL1B; interleukin 1 beta
       K03456  PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
       K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
       K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
       K04687  IFNG; interferon gamma
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
       K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
       K03990  C3; complement component 3
       K08057  CALR; calreticulin
       K03986  C1QA; complement C1q subcomponent subunit A
       K03987  C1QB; complement C1q subcomponent subunit B
       K03988  C1QG; complement C1q subcomponent subunit C
       K08571  E3.4.22.51; cruzipain [EC:3.4.22.51]
       K05443  IL10, CSIF; interleukin 10
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K01283  ACE, CD143; peptidyl-dipeptidase A [EC:3.4.15.1]
       K03916  BDKRB2; bradykinin receptor B2
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
       K04636  GNA14; guanine nucleotide-binding protein subunit alpha-14
       K04637  GNA15; guanine nucleotide-binding protein subunit alpha-15
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K01354  ptrB; oligopeptidase B [EC:3.4.21.83]
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
       K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
       K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
       K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
       K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
       K06453  CD3Z, CD247; CD3Z antigen, zeta polypeptide
       K05429  IL2; interleukin 2
     05143 African trypanosomiasis [PATH:ko05143]
 
   Drug resistance

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Last updated: February 26, 2017