KEGG Orthology (KO)

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 Metabolism
 
 Genetic Information Processing
 
 Environmental Information Processing
 
 Cellular Processes
 
 Organismal Systems
 
   Immune system
 
   Endocrine system
     04911 Insulin secretion [PATH:ko04911]
     04910 Insulin signaling pathway [PATH:ko04910]
     04920 Adipocytokine signaling pathway [PATH:ko04920]
     03320 PPAR signaling pathway [PATH:ko03320]
     04912 GnRH signaling pathway [PATH:ko04912]
     04913 Ovarian Steroidogenesis [PATH:ko04913]
     04915 Estrogen signaling pathway [PATH:ko04915]
     04914 Progesterone-mediated oocyte maturation [PATH:ko04914]
     04917 Prolactin signaling pathway [PATH:ko04917]
     04921 Oxytocin signaling pathway [PATH:ko04921]
     04918 Thyroid hormone synthesis [PATH:ko04918]
     04919 Thyroid hormone signaling pathway [PATH:ko04919]
     04916 Melanogenesis [PATH:ko04916]
     04614 Renin-angiotensin system [PATH:ko04614]
       K09821  AGT; angiotensinogen
       K01380  REN; renin [EC:3.4.23.15]
       K01283  E3.4.15.1, ACE; peptidyl-dipeptidase A [EC:3.4.15.1]
       K09708  ACEH, ACE2; angiotensin-converting enzyme 2 [EC:3.4.17.23]
       K01329  CMA1; chymase [EC:3.4.21.39]
       K01319  CTSG; cathepsin G [EC:3.4.21.20]
       K11141  ENPEP; glutamyl aminopeptidase [EC:3.4.11.7]
       K11140  ANPEP; aminopeptidase N [EC:3.4.11.2]
       K13289  CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
       K08780  CPA3; carboxypeptidase A3 [EC:3.4.17.1]
       K01389  MME; neprilysin [EC:3.4.24.11]
       K01392  THOP1; thimet oligopeptidase [EC:3.4.24.15]
       K01393  NLN; neurolysin [EC:3.4.24.16]
       K04303  MAS1; MAS1 oncogene
       K04166  AGTR1; angiotensin II receptor type 1
       K04167  AGTR2; angiotensin II receptor type 2
       K01257  LNPEP; cystinyl aminopeptidase [EC:3.4.11.3]
 
   Circulatory system
 
   Digestive system
 
   Excretory system
 
   Nervous system
 
   Sensory system
 
   Development
 
   Environmental adaptation
 
 Human Diseases
 
   Cancers
 
   Immune diseases
 
   Neurodegenerative diseases
 
   Substance dependence
 
   Cardiovascular diseases
     05410 Hypertrophic cardiomyopathy (HCM) [PATH:ko05410]
       K06480  ITGA1; integrin alpha 1
       K06481  ITGA2; integrin alpha 2
       K06476  ITGA2B; integrin alpha 2B
       K06482  ITGA3; integrin alpha 3
       K06483  ITGA4; integrin alpha 4
       K06484  ITGA5; integrin alpha 5
       K06485  ITGA6; integrin alpha 6
       K06583  ITGA7; integrin alpha 7
       K06584  ITGA8; integrin alpha 8
       K06585  ITGA9; integrin alpha 9
       K06586  ITGA10; integrin alpha 10
       K06587  ITGA11; integrin alpha 11
       K06487  ITGAV; integrin alpha V
       K05719  ITGB1; integrin beta 1
       K06493  ITGB3; integrin beta 3
       K06525  ITGB4; integrin beta 4
       K06588  ITGB5; integrin beta 5
       K06589  ITGB6; integrin beta 6
       K06590  ITGB7; integrin beta 7
       K06591  ITGB8; integrin beta 8
       K12563  SGCD; delta-sarcoglycan
       K12564  SGCG; gamma-sarcoglycan
       K12565  SGCA; alpha-sarcoglycan
       K12566  SGCB; beta-sarcoglycan
       K06265  DAG1; dystroglycan 1
       K07610  DES; desmin
       K10366  DMD; dystrophin
       K05692  ACTB_G1; actin beta/gamma 1
       K12567  TTN; titin [EC:2.7.11.1]
       K12045  TNNT2; troponin T, cardiac muscle
       K05865  TNNC1; troponin C, slow skeletal and cardiac muscles
       K12044  TNNI3; troponin I, cardiac muscle
       K12314  ACTC1; actin, alpha cardiac muscle
       K10373  TPM1; tropomyosin 1
       K10374  TPM2; tropomyosin 2
       K09290  TPM3; tropomyosin 3
       K10375  TPM4; tropomyosin 4
       K12568  MYBPC3; myosin-binding protein C, cardiac-type
       K12749  MYL3; myosin light chain 3
       K10351  MYL2; myosin regulatory light chain 2
       K12569  EMD; emerin
       K12641  LMNA; lamin A/C
       K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
       K04851  CACNA1D; voltage-dependent calcium channel L type alpha-1D
       K04853  CACNA1F; voltage-dependent calcium channel L type alpha-1F
       K04857  CACNA1S; voltage-dependent calcium channel L type alpha-1S
       K04862  CACNB1; voltage-dependent calcium channel beta-1
       K04863  CACNB2; voltage-dependent calcium channel beta-2
       K04864  CACNB3; voltage-dependent calcium channel beta-3
       K04865  CACNB4; voltage-dependent calcium channel beta-4
       K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
       K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
       K04860  CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
       K04861  CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
       K04866  CACNG1; voltage-dependent calcium channel gamma-1
       K04867  CACNG2; voltage-dependent calcium channel gamma-2
       K04868  CACNG3; voltage-dependent calcium channel gamma-3
       K04869  CACNG4; voltage-dependent calcium channel gamma-4
       K04870  CACNG5; voltage-dependent calcium channel gamma-5
       K04871  CACNG6; voltage-dependent calcium channel gamma-6
       K04872  CACNG7; voltage-dependent calcium channel gamma-7
       K04873  CACNG8; voltage-dependent calcium channel gamma-8
       K04962  RYR2; ryanodine receptor 2
       K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
       K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
       K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
       K01283  E3.4.15.1, ACE; peptidyl-dipeptidase A [EC:3.4.15.1]
       K05459  IGF1; insulin-like growth factor 1
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K05405  IL6; interleukin 6
       K16366  EDN1; endothelin-1
       K09821  AGT; angiotensinogen
     05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) [PATH:ko05412]
     05414 Dilated cardiomyopathy (DCM) [PATH:ko05414]
     05416 Viral myocarditis [PATH:ko05416]
 
   Endocrine and metabolic diseases
 
   Infectious diseases
     05110 Vibrio cholerae infection [PATH:ko05110]
     05111 Vibrio cholerae pathogenic cycle [PATH:ko05111]
     05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
     05130 Pathogenic Escherichia coli infection [PATH:ko05130]
     05132 Salmonella infection [PATH:ko05132]
     05131 Shigellosis [PATH:ko05131]
     05133 Pertussis [PATH:ko05133]
     05134 Legionellosis [PATH:ko05134]
     05150 Staphylococcus aureus infection [PATH:ko05150]
     05152 Tuberculosis [PATH:ko05152]
     05100 Bacterial invasion of epithelial cells [PATH:ko05100]
     05166 HTLV-I infection [PATH:ko05166]
     05162 Measles [PATH:ko05162]
     05164 Influenza A [PATH:ko05164]
     05161 Hepatitis B [PATH:ko05161]
     05160 Hepatitis C [PATH:ko05160]
     05168 Herpes simplex infection [PATH:ko05168]
     05169 Epstein-Barr virus infection [PATH:ko05169]
     05146 Amoebiasis [PATH:ko05146]
     05144 Malaria [PATH:ko05144]
     05145 Toxoplasmosis [PATH:ko05145]
     05140 Leishmaniasis [PATH:ko05140]
     05142 Chagas disease (American trypanosomiasis) [PATH:ko05142]
       K10160  TLR4; toll-like receptor 4
       K05842  TRIF; toll-like receptor adapter molecule 1
       K13729  TCAC2, TC52; thiol-dependent reductase 1
       K10159  TLR2; toll-like receptor 2
       K10169  TLR6; toll-like receptor 6
       K10161  TLR9; toll-like receptor 9
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K04730  IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K03175  TRAF6; TNF receptor-associated factor 6
       K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04379  FOS; proto-oncogene protein c-fos
       K04448  JUN; transcription factor AP-1
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K05415  IFNB; interferon beta
       K12499  CCL5; C-C motif chemokine 5
       K14624  CCL2, MCP1; C-C motif chemokine 2
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K05406  IL12A; interleukin 12A
       K05425  IL12B; interleukin 12B
       K05405  IL6; interleukin 6
       K10030  IL8, CXCL8; interleukin 8
       K05408  CCL3; C-C motif chemokine 3
       K04519  IL1B; interleukin 1 beta
       K03456  PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
       K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
       K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
       K04687  IFNG; interferon gamma
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K03158  TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
       K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
       K03990  C3; complement component 3
       K08057  CALR; calreticulin
       K03986  C1QA; complement C1q subcomponent subunit A
       K03987  C1QB; complement C1q subcomponent subunit B
       K03988  C1QG; complement C1q subcomponent subunit C
       K08571  E3.4.22.51; cruzipain [EC:3.4.22.51]
       K05443  IL10, CSIF; interleukin 10
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K01283  E3.4.15.1, ACE; peptidyl-dipeptidase A [EC:3.4.15.1]
       K03916  BDKRB2; bradykinin receptor B2
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
       K04636  GNA14; guanine nucleotide-binding protein subunit alpha-14
       K04637  GNA15; guanine nucleotide-binding protein subunit alpha-15
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K01354  ptrB; oligopeptidase B [EC:3.4.21.83]
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
       K03982  SERPINE1, PAI1; plasminogen activator inhibitor-1
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
       K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
       K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
       K06453  CD3Z; CD3Z antigen, zeta polypeptide
       K05429  IL2; interleukin 2
     05143 African trypanosomiasis [PATH:ko05143]
 
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Last updated: July 26, 2014