 Metabolism
|
|
 Genetic Information Processing
|
|
Transcription
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Translation
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|
Folding, sorting and degradation
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 03110 Chaperones and folding catalysts [BR:ko03110]
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03060 Protein export [PATH:ko03060]
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04141 Protein processing in endoplasmic reticulum [PATH:ko04141]
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K10956 SEC61A; protein transport protein SEC61 subunit alpha
K09481 SEC61B, SBH2; protein transport protein SEC61 subunit beta
K07342 SEC61G, SSS1, secE; protein transport protein SEC61 subunit gamma and related proteins
K12275 SEC62; translocation protein SEC62
K09540 SEC63; translocation protein SEC63
K12666 OST1, RPN1; oligosaccharyltransferase complex subunit alpha (ribophorin I)
K12667 SWP1, RPN2; oligosaccharyltransferase complex subunit delta (ribophorin II)
K12668 OST2, DAD1; oligosaccharyltransferase complex subunit epsilon
K12669 OST3, OST6; oligosaccharyltransferase complex subunit gamma
K12670 WBP1; oligosaccharyltransferase complex subunit beta
K00730 OST4; oligosaccharyl transferase complex subunit OST4
K12691 OST5; oligosaccharyl transferase complex subunit OST5
K07151 STT3; dolichyl-diphosphooligosaccharide--protein glycosyltransferase [EC:2.4.99.18]
K01228 GCS1; mannosyl-oligosaccharide glucosidase [EC:3.2.1.106]
K13999 CKAP4, CLIMP63; cytoskeleton-associated protein 4
K14000 RRBP1; ribosome-binding protein 1
K14001 SIL1, SLS1; nucleotide exchange factor SIL1
K09486 HYOU1; hypoxia up-regulated 1
K09490 HSPA5, BIP; heat shock 70kDa protein 5
K09517 DNAJB11; DnaJ homolog subfamily B member 11
K09521 DNAJC1; DnaJ homolog subfamily C member 1
K09523 DNAJC3; DnaJ homolog subfamily C member 3
K09530 DNAJC10; DnaJ homolog subfamily C member 10
K14002 SCJ1; DnaJ-related protein SCJ1
K09487 HSP90B, TRA1; heat shock protein 90kDa beta
K05546 GANAB; alpha 1,3-glucosidase [EC:3.2.1.84]
K08288 PRKCSH; protein kinase C substrate 80K-H
K08054 CANX; calnexin
K08056 PDIA3, GRP58; protein disulfide isomerase family A, member 3 [EC:5.3.4.1]
K08057 CALR; calreticulin
K01230 MAN1; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
K10082 LMAN2, VIP36; lectin, mannose-binding 2
K10080 LMAN1, ERGIC53; lectin, mannose-binding 1
K10081 LMAN1L, ERGL; lectin, mannose-binding 1-like
K14003 PREB, SEC12; prolactin regulatory element-binding protein
K07953 SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]
K14004 SEC13; protein transport protein SEC13
K14005 SEC31; protein transport protein SEC31
K14006 SEC23; protein transport protein SEC23
K14007 SEC24; protein transport protein SEC24
K11718 HUGT; UDP-glucose:glycoprotein glucosyltransferase [EC:2.4.1.-]
K10084 EDEM1; ER degradation enhancer, mannosidase alpha-like 1
K10085 EDEM2; ER degradation enhancer, mannosidase alpha-like 2
K10086 EDEM3; ER degradation enhancer, mannosidase alpha-like 3
K09580 PDIA1, P4HB; protein disulfide-isomerase A1 [EC:5.3.4.1]
K09582 PDIA4, ERP72; protein disulfide-isomerase A4 [EC:5.3.4.1]
K09584 PDIA6, TXNDC7; protein disulfide-isomerase A6 [EC:5.3.4.1]
K13996 EPS1; protein disulfide-isomerase [EC:5.3.4.1]
K09586 ERP29; endoplasmic reticulum protein 29
K13984 TXNDC5, ERP46; thioredoxin domain-containing protein 5
K10950 ERO1L; ERO1-like protein alpha [EC:1.8.4.-]
K10976 ERO1LB; ERO1-like protein beta [EC:1.8.4.-]
K10088 OS9; protein OS-9
K14008 ERLEC1, XTP3B; endoplasmic reticulum lectin 1
K13249 SSR1; translocon-associated protein subunit alpha
K13250 SSR2; translocon-associated protein subunit beta
K13251 SSR3; translocon-associated protein subunit gamma
K04571 SSR4; translocon-associated protein subunit delta
K14009 BCAP31, BAP31; B-cell receptor-associated protein 31
K14010 TRAM1; translocating chain-associated membrane protein 1
K11519 DERL1; Derlin-1
K13989 DERL2_3; Derlin-2/3
K14011 UBXN6, UBXD1; UBX domain-containing protein 6
K14012 SHP1, UBX1, NSFL1C; UBX domain-containing protein 1
K14013 UBX2, SEL1; UBX domain-containing protein 2
K14014 SVIP; small VCP/p97-interacting protein
K13525 VCP, CDC48; transitional endoplasmic reticulum ATPase
K14015 NPLOC4, NPL4; nuclear protein localization protein 4 homolog
K14016 UFD1; ubiquitin fusion degradation protein 1
K03283 HSPA1_8; heat shock 70kDa protein 1/8
K09502 DNAJA1; DnaJ homolog subfamily A member 1
K09503 DNAJA2; DnaJ homolog subfamily A member 2
K09507 DNAJB1; DnaJ homolog subfamily B member 1
K09508 DNAJB2; DnaJ homolog subfamily B member 2
K09518 DNAJB12; DnaJ homolog subfamily B member 12
K09525 DNAJC5; DnaJ homolog subfamily C member 5
K04079 htpG, HSP90A; molecular chaperone HtpG
K09485 HSP110; heat shock protein 110kDa
K09555 BAG1; BCL2-associated athanogene 1
K09556 BAG2; BCL2-associated athanogene 2
K09562 HSPBP1; hsp70-interacting protein
K14017 SNL1; HSP70 co-chaperone SNL1
K09541 CRYAA; crystallin, alpha A
K09542 CRYAB; crystallin, alpha B
K13993 HSP20; HSP20 family protein
K13719 OTU1, YOD1; ubiquitin thioesterase OTU1 [EC:3.1.2.-]
K14018 PLAA, DOA1, UFD3; phospholipase A-2-activating protein
K10839 RAD23, HR23; UV excision repair protein RAD23
K04523 UBQLN, DSK2; ubiquilin
K01456 E3.5.1.52, NGLY1, PNG1; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase [EC:3.5.1.52]
K11863 ATXN3, MJD; Ataxin-3 [EC:3.4.22.-]
K10597 UBE4B, UFD2; ubiquitin conjugation factor E4 B [EC:6.3.2.19]
K16194 EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
K08860 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
K16196 EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]
K03237 EIF2S1; translation initiation factor 2 subunit 1
K05638 NFE2L2, NRF2; nuclear factor erythroid 2-related factor 2
K04374 ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
K14019 PPP1R15A, GADD34; protein phosphatase 1 regulatory subunit 15A
K04452 DDIT3, GADD153; DNA damage-inducible transcript 3
K02161 BCL2; apoptosis regulator BCL-2
K09054 ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
K09049 ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
K14020 WFS1; wolfamin
K08653 MBTPS1; membrane-bound transcription factor site-1 protease [EC:3.4.21.112]
K07765 MBTPS2; S2P endopeptidase [EC:3.4.24.85]
K09027 XBP1; X box-binding protein 1
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]
K03173 TRAF2; TNF receptor-associated factor 2
K04426 MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04431 MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K02159 BAX; apoptosis regulator BAX
K14021 BAK, BAK1; Bcl-2 homologous antagonist/killer
K01367 CAPN1; calpain-1 [EC:3.4.22.52]
K03853 CAPN2; calpain-2 [EC:3.4.22.53]
K04741 CASP12; caspase 12 [EC:3.4.22.-]
K10661 MARCH6, DOA10; E3 ubiquitin-protein ligase MARCH6 [EC:6.3.2.19]
K10578 UBE2J1, NCUBE1, UBC6; ubiquitin-conjugating enzyme E2 J1 [EC:6.3.2.19]
K04554 UBE2J2, NCUBE2, UBC6; ubiquitin-conjugating enzyme E2 J2 [EC:6.3.2.19]
K10575 UBE2G1, UBC7; ubiquitin-conjugating enzyme E2 G1 [EC:6.3.2.19]
K04555 UBE2G2, UBC7; ubiquitin-conjugating enzyme E2 G2 [EC:6.3.2.19]
K14022 CUE1, KIS4; coupling of ubiquitin conjugation to ER degradation protein 1
K14023 HRD3; ERAD-associated E3 ubiquitin-protein ligase component HRD3
K10601 SYVN1, HRD1; E3 ubiquitin-protein ligase synoviolin [EC:6.3.2.19]
K14024 USA1; U1 SNP1-associating protein 1
K10666 RNF5; E3 ubiquitin-protein ligase RNF5 [EC:6.3.2.19]
K14025 SELS, VIMP; selenoprotein S
K14026 SEL1, SEL1L; SEL1 protein
K14027 HERPUD1, HERP; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
K10636 AMFR, GP78; autocrine motility factor receptor [EC:6.3.2.19]
K09561 STUB1, CHIP; STIP1 homology and U-box containing protein 1 [EC:6.3.2.19]
K06689 UBE2D_E, UBC4, UBC5; ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19]
K04556 PARK2; parkin [EC:6.3.2.19]
K03868 RBX1, ROC1; RING-box protein 1
K03347 CUL1, CDC53; cullin 1
K03094 SKP1, CBF3D; S-phase kinase-associated protein 1
K10099 FBXO2, NFB42; F-box protein 2
K10100 FBXO6; F-box protein 6
|
04130 SNARE interactions in vesicular transport [PATH:ko04130]
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04131 SNAREs [BR:ko04131]
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04120 Ubiquitin mediated proteolysis [PATH:ko04120]
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04121 Ubiquitin system [BR:ko04121]
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04122 Sulfur relay system [PATH:ko04122]
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03050 Proteasome [PATH:ko03050]
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03051 Proteasome [BR:ko03051]
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03018 RNA degradation [PATH:ko03018]
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Replication and repair
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RNA family
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Environmental Information Processing
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Membrane transport
|
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Signal transduction
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02020 Two-component system [PATH:ko02020]
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02022 Two-component system [BR:ko02022]
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04010 MAPK signaling pathway [PATH:ko04010]
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K04344 CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
K04849 CACNA1B; voltage-dependent calcium channel N type alpha-1B
K04850 CACNA1C; voltage-dependent calcium channel L type alpha-1C
K04851 CACNA1D; voltage-dependent calcium channel L type alpha-1D
K04852 CACNA1E; voltage-dependent calcium channel R type alpha-1E
K04853 CACNA1F; voltage-dependent calcium channel L type alpha-1F
K04854 CACNA1G; voltage-dependent calcium channel T type alpha-1G
K04855 CACNA1H; voltage-dependent calcium channel T type alpha-1H
K04856 CACNA1I; voltage-dependent calcium channel T type alpha-1I
K04857 CACNA1S; voltage-dependent calcium channel L type alpha-1S
K05315 CACNA1N; voltage-dependent calcium channel alpha 1, invertebrate
K04858 CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
K04859 CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
K04860 CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
K04861 CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
K05316 CACNA2DN; voltage-dependent calcium channel alpha-2/delta, invertebrate
K04862 CACNB1; voltage-dependent calcium channel beta-1
K04863 CACNB2; voltage-dependent calcium channel beta-2
K04864 CACNB3; voltage-dependent calcium channel beta-3
K04865 CACNB4; voltage-dependent calcium channel beta-4
K05317 CACNBN; voltage-dependent calcium channel beta, invertebrate
K04866 CACNG1; voltage-dependent calcium channel gamma-1
K04867 CACNG2; voltage-dependent calcium channel gamma-2
K04868 CACNG3; voltage-dependent calcium channel gamma-3
K04869 CACNG4; voltage-dependent calcium channel gamma-4
K04870 CACNG5; voltage-dependent calcium channel gamma-5
K04871 CACNG6; voltage-dependent calcium channel gamma-6
K04872 CACNG7; voltage-dependent calcium channel gamma-7
K04873 CACNG8; voltage-dependent calcium channel gamma-8
K04345 PKA; protein kinase A [EC:2.7.11.11]
K02677 CPKC; classical protein kinase C [EC:2.7.11.13]
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
K04347 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K04348 PPP3C, CNA; protein phosphatase 3, catalytic subunit [EC:3.1.3.16]
K06268 PPP3R, CNB; protein phosphatase 3, regulatory subunit
K04349 RASGRF1; Ras-specific guanine nucleotide-releasing factor 1
K12326 RASGRF2; Ras-specific guanine nucleotide-releasing factor 2
K04350 RASGRP1; RAS guanyl-releasing protein 1
K12361 RASGRP2; RAS guanyl-releasing protein 2
K12362 RASGRP3; RAS guanyl-releasing protein 3
K12363 RASGRP4; RAS guanyl-releasing protein 4
K08018 RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor (GEF) 2
K08052 NF1; neurofibromin 1
K04352 RASA1, RASGAP; Ras GTPase-activating protein 1
K08053 RASA2, GAP1M; Ras GTPase-activating protein 2
K04353 RAP1A; Ras-related protein Rap-1A
K07836 RAP1B; Ras-related protein Rap-1B
K02582 NGFB; nerve growth factor, beta
K04355 BDNF; brain-derived neurotrophic factor
K04356 NTF3; neurotrophin 3
K12457 NTF4; neurotrophin 4
K04357 EGF; epidermal growth factor
K04358 FGF; fibroblast growth factor
K04359 PDGFA_B; platelet derived growth factor A/B
K03176 NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K04360 NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094 FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
K05095 FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-binding protein 2
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS, KRAS2; GTPase KRas
K07828 NRAS; GTPase NRas
K07829 RRAS; Ras-related protein R-Ras
K07830 RRAS2, TC21; Ras-related protein R-Ras2
K07831 MRAS; Ras-related protein M-Ras
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04367 MOS; proto-oncogene serine/threonine-protein kinase mos [EC:2.7.11.1]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04370 MP1, MAP2K1IP1; mitogen-activated protein kinase kinase 1 interacting protein 1
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K04372 MKNK, MNK; MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]
K04373 RPS6KA, RSK2; p90 ribosomal S6 kinase [EC:2.7.11.1]
K04374 ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
K04375 ELK1; ETS domain-containing protein Elk-1
K04376 ELK4, SAP1; ETS domain-containing protein Elk-4
K04377 MYC; Myc proto-oncogene protein
K04378 SRF; serum response factor
K04379 FOS; proto-oncogene protein c-fos
K04380 MAPT, TAU; microtubule-associated protein tau
K04381 STMN1; stathmin
K16342 PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]
K03156 TNFA; tumor necrosis factor superfamily, member 2
K04383 IL1A; interleukin 1 alpha
K04519 IL1B; interleukin 1 beta
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K03158 TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
K04386 IL1R1; interleukin 1 receptor type I
K04387 IL1R2; interleukin 1 receptor type II
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04389 TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
K04391 CD14; CD14 antigen
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K04393 CDC42; cell division control protein 42
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K03173 TRAF2; TNF receptor-associated factor 2
K02308 DAXX; death-associated protein 6
K03175 TRAF6; TNF receptor-associated factor 6
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04403 MAP3K7IP1, TAB1; TAK1-binding protein 1
K04404 MAP3K7IP2, TAB2; TAK1-binding protein 2
K04405 SITPEC, ECSIT; evolutionarily conserved signaling intermediate in Toll pathways
K04406 MAP4K3, GLK; mitogen-activated protein kinase kinase kinase kinase 3 [EC:2.7.11.1]
K04407 MAP4K4, HGK; mitogen-activated protein kinase kinase kinase kinase 4 [EC:2.7.11.1]
K04408 MAP4K1, HPK1; mitogen-activated protein kinase kinase kinase kinase 1 [EC:2.7.11.1]
K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
K04410 PAK2; p21-activated kinase 2 [EC:2.7.11.1]
K04411 STK4, MST1; serine/threonine kinase 4
K04412 STK3, MST2; serine/threonine kinase 3
K04414 MAP4K2, GCK; mitogen-activated protein kinase kinase kinase kinase 2 [EC:2.7.11.1]
K04415 MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8 [EC:2.7.11.25]
K04416 MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
K04419 MAP3K11, MLK3; mitogen-activated protein kinase kinase kinase 11 [EC:2.7.11.25]
K04420 MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2 [EC:2.7.11.25]
K04421 MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]
K04422 MAP3K13, LZK; mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25]
K04423 MAP3K12, MUK; mitogen-activated protein kinase kinase kinase 12 [EC:2.7.11.25]
K04424 ZAK, MLTK; sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25]
K04425 MAP3K6, ASK2; mitogen-activated protein kinase kinase kinase 6 [EC:2.7.11.25]
K04426 MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K04428 MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25]
K04429 TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]
K04430 MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
K04431 MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04432 MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
K04433 MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
K04434 MAPK8IP1, JIP1; mitogen-activated protein kinase 8 interacting protein 1
K04435 MAPK8IP2, JIP2; mitogen-activated protein kinase 8 interacting protein 2
K04436 MAPK8IP3, JIP3; mitogen-activated protein kinase 8 interacting protein 3
K04437 FLNA; filamin
K04438 CRK, CRKII; proto-oncogene C-crk
K04439 ARRB; beta-arrestin
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04442 MAPKAPK5, PRAK; mitogen-activated protein kinase-activated protein kinase 5 [EC:2.7.11.1]
K04443 MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
K04444 MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]
K04445 MSK1, RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
K16510 MSK2, RPS6KA4; ribosomal protein S6 kinase alpha-4 [EC:2.7.11.1]
K05866 CDC25B; cell division cycle 25B [EC:3.1.3.48]
K04448 JUN; transcription factor AP-1
K04449 JUND; transcription factor jun-D
K04450 ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
K04451 TP53, P53; tumor protein p53
K04452 DDIT3, GADD153; DNA damage-inducible transcript 3
K04453 MAX; Max protein
K04454 MEF2C; MADS-box transcription enhancer factor 2C
K04455 HSPB1; heat shock protein beta-1
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04457 PPM1A, PP2CA; protein phosphatase 1A (formerly 2C) [EC:3.1.3.16]
K04458 PTP; protein-tyrosine phosphatase [EC:3.1.3.48]
K04459 DUSP, MKP; dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]
K04460 PPP5C, PP5; protein phosphatase 5 [EC:3.1.3.16]
K04461 PPM1B, PP2CB; protein phosphatase 1B (formerly 2C) [EC:3.1.3.16]
K03283 HSPA1_8; heat shock 70kDa protein 1/8
K04462 EVI1; ecotropic virus integration site 1 protein
K04463 MAP2K5, MEK5; mitogen-activated protein kinase kinase 5 [EC:2.7.12.2]
K04464 MAPK7, ERK5; mitogen-activated protein kinase 7 [EC:2.7.11.24]
K04465 NR4A1, HMR; nuclear receptor subfamily 4 group A member 1
K04466 MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04468 NLK; nemo like kinase [EC:2.7.11.24]
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04735 RELA; transcription factor p65
K09253 RELB; transcription factor RelB
|
04013 MAPK signaling pathway - fly [PATH:ko04013]
|
04011 MAPK signaling pathway - yeast [PATH:ko04011]
|
04012 ErbB signaling pathway [PATH:ko04012]
|
04310 Wnt signaling pathway [PATH:ko04310]
|
04330 Notch signaling pathway [PATH:ko04330]
|
04340 Hedgehog signaling pathway [PATH:ko04340]
|
04350 TGF-beta signaling pathway [PATH:ko04350]
|
04390 Hippo signaling pathway [PATH:ko04390]
|
04391 Hippo signaling pathway -fly [PATH:ko04391]
|
04370 VEGF signaling pathway [PATH:ko04370]
|
04630 Jak-STAT signaling pathway [PATH:ko04630]
|
04064 NF-kappa B signaling pathway [PATH:ko04064]
|
K10784 TRAV; T cell receptor alpha chain V region
K10785 TRBV; T-cell receptor beta chain V region
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
K07360 ZAP70; tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]
K07362 LAT; linker for activation of T cells
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K06856 IGH; immunoglobulin heavy chain
K05855 SYK; spleen tyrosine kinase [EC:2.7.10.2]
K05854 LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
K07371 BLNK; B-cell linker protein
K07370 BTK; Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K07367 CARD11; caspase recruitment domain-containing protein 11
K07368 BCL10; B-cell CLL/lymphoma 10
K07369 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
K04519 IL1B; interleukin 1 beta
K04386 IL1R1; interleukin 1 receptor type I
K04729 MYD88; myeloid differentiation primary response protein MyD88
K04730 IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
K04733 IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
K03175 TRAF6; TNF receptor-associated factor 6
K03156 TNFA; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
K02861 RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K03173 TRAF2; TNF receptor-associated factor 2
K09849 TRAF5; TNF receptor-associated factor 5
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K12646 DDX58, RIG-I; ATP-dependent RNA helicase DDX58 [EC:3.6.3.14]
K10652 TRIM25, EFP; tripartite motif-containing protein 25
K05399 LBP; lipopolysaccharide-binding protein
K04391 CD14; CD14 antigen
K10160 TLR4; toll-like receptor 4
K05400 LY96, MD-2; lymphocyte antigen 96
K05403 TIRAP; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
K05409 TIRP, TRAM; TRIF-related adaptor molecule
K05842 TRIF; toll-like receptor adapter molecule 1
K03161 TNFSF5, CD40L; tumor necrosis factor ligand superfamily member 5
K03160 TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
K03174 TRAF3; TNF receptor-associated factor 3
K05473 TNFSF11, RANKL; tumor necrosis factor ligand superfamily member 11
K05147 TNFRSF11A, RANK; tumor necrosis factor receptor superfamily member 11A
K05468 LTA, TNFB; lymphotoxin alpha (TNF superfamily, member 1)
K03157 LTB, TNFC; lymphotoxin beta (TNF superfamily, member 3)
K05477 TNFSF14, LIGHT; tumor necrosis factor ligand superfamily member 14
K03159 TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3
K04466 MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K04403 MAP3K7IP1, TAB1; TAK1-binding protein 1
K04404 MAP3K7IP2, TAB2; TAK1-binding protein 2
K12793 MAP3K7IP3, TAB3; TAK1-binding protein 3
K05476 TNFSF13B, TNFSF20; tumor necrosis factor ligand superfamily member 13B
K05151 TNFRSF13C, BAFFR; tumor necrosis factor receptor superfamily member 13C
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K16065 PIAS4; E3 SUMO-protein ligase PIAS4 [EC:6.3.2.-]
K10577 UBE2I, UBC9; ubiquitin-conjugating enzyme E2 I [EC:6.3.2.19]
K04728 ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
K10130 LRDD, PIDD; leucine-rich repeats and death domain-containing protein
K16072 ERC1; ELKS/RAB6-interacting/CAST family member 1
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K04724 CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
K04725 XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
K04570 BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
K02161 BCL2; apoptosis regulator BCL-2
K03172 TRAF1; TNF receptor-associated factor 1
K02162 BCL2A1; hematopoietic BCL2-related protein A1
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K10030 IL8, CXCL8; interleukin 8
K11859 TNFAIP3, A20; tumor necrosis factor, alpha-induced protein 3 [EC:3.-.-.-]
K11987 PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K12964 CCL4; C-C motif chemokine 4
K06527 VCAM1; vascular cell adhesion molecule 1
K01348 PLAU; urokinase plasminogen activator [EC:3.4.21.73]
K03097 CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]
K03115 CSNK2B; casein kinase II subunit beta
K09253 RELB; transcription factor RelB
K16595 CCL13; C-C motif chemokine 13
K05512 CCL19, ELC; C-C motif chemokine 19
K16062 CCL21, SLC; C-C motif chemokine 21
K10031 CXCL12; C-X-C motif chemokine 12
K06490 ICAM1; intercellular adhesion molecule 1
|
04066 HIF-1 signaling pathway [PATH:ko04066]
|
04020 Calcium signaling pathway [PATH:ko04020]
|
04070 Phosphatidylinositol signaling system [PATH:ko04070]
|
04151 PI3K-Akt signaling pathway [PATH:ko04151]
|
04150 mTOR signaling pathway [PATH:ko04150]
|
04075 Plant hormone signal transduction [PATH:ko04075]
|
|
Signaling molecules and interaction
|
|
Cellular Processes
|
|
Transport and catabolism
|
|
Cell motility
|
|
Cell growth and death
|
04110 Cell cycle [PATH:ko04110]
|
04111 Cell cycle - yeast [PATH:ko04111]
|
04112 Cell cycle - Caulobacter [PATH:ko04112]
|
04113 Meiosis - yeast [PATH:ko04113]
|
04114 Oocyte meiosis [PATH:ko04114]
|
04210 Apoptosis [PATH:ko04210]
|
K04389 TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
K04721 TNFSF10, TRAIL; tumor necrosis factor ligand superfamily member 10
K04722 TNFRSF10, TRAILR; tumor necrosis factor receptor superfamily member 10
K03156 TNFA; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
K04383 IL1A; interleukin 1 alpha
K04519 IL1B; interleukin 1 beta
K04386 IL1R1; interleukin 1 receptor type I
K04723 IL1RAP; interleukin 1 receptor accessory protein
K02373 FADD; FAS-associated death domain protein
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K04724 CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
K04400 CASP10; caspase 10 [EC:3.4.22.63]
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04397 CASP7; caspase 7 [EC:3.4.22.60]
K04396 CASP6; caspase 6 [EC:3.4.22.59]
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K04726 BID; BH3 interacting domain death agonist
K02161 BCL2; apoptosis regulator BCL-2
K04570 BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K02310 DFFA, DFF45; DNA fragmentation factor, 45 kD, alpha subunit
K02311 DFFB, DFF40; DNA fragmentation factor, 40 kD, beta subunit [EC:3.-.-.-]
K04727 PDCD8, AIF; programmed cell death 8 (apoptosis-inducing factor) [EC:1.-.-.-]
K01173 ENDOG; endonuclease G, mitochondrial
K04728 ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
K04451 TP53, P53; tumor protein p53
K02861 RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
K03173 TRAF2; TNF receptor-associated factor 2
K04729 MYD88; myeloid differentiation primary response protein MyD88
K04730 IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
K04731 IRAK2; interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1]
K04732 IRAK3; interleukin-1 receptor-associated kinase 3 [EC:2.7.11.1]
K04733 IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
K04466 MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K02582 NGFB; nerve growth factor, beta
K03176 NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K04736 IL3; interleukin 3
K04737 IL3RA; interleukin 3 receptor alpha
K04738 CSF2RB, IL3RB; cytokine receptor common subunit beta
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04739 PRKAR; cAMP-dependent protein kinase regulator
K04345 PKA; protein kinase A [EC:2.7.11.11]
K02158 BAD; BCL2-antagonist of cell death
K02159 BAX; apoptosis regulator BAX
K04348 PPP3C, CNA; protein phosphatase 3, catalytic subunit [EC:3.1.3.16]
K06268 PPP3R, CNB; protein phosphatase 3, regulatory subunit
K01367 CAPN1; calpain-1 [EC:3.4.22.52]
K03853 CAPN2; calpain-2 [EC:3.4.22.53]
K04741 CASP12; caspase 12 [EC:3.4.22.-]
|
04115 p53 signaling pathway [PATH:ko04115]
|
|
Cell communication
|
|
Organismal Systems
|
|
Immune system
|
04640 Hematopoietic cell lineage [PATH:ko04640]
|
04610 Complement and coagulation cascades [PATH:ko04610]
|
04620 Toll-like receptor signaling pathway [PATH:ko04620]
|
04621 NOD-like receptor signaling pathway [PATH:ko04621]
|
04622 RIG-I-like receptor signaling pathway [PATH:ko04622]
|
K12646 DDX58, RIG-I; ATP-dependent RNA helicase DDX58 [EC:3.6.3.14]
K12647 IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13]
K12648 MAVS, IPS1; mitochondrial antiviral-signaling protein
K12649 DHX58, LGP2; ATP-dependent RNA helicase DHX58 [EC:3.6.3.14]
K03174 TRAF3; TNF receptor-associated factor 3
K12650 TANK; TRAF family member-associated NF-kappa-B activator
K12651 AZI2; 5-azacytidine-induced protein 2
K12652 TBKBP1; TANK-binding kinase 1-binding protein
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K05410 TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
K07211 IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
K05411 IRF3; interferon regulatory factor 3
K09447 IRF7; interferon regulatory factor 7
K05414 IFNA; interferon alpha
K05415 IFNB; interferon beta
K05440 IFNW1; interferon, omega 1
K05442 IFNT1; interferon, tau-1
K05441 IFNK; interferon, kappa
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K02373 FADD; FAS-associated death domain protein
K02861 RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04400 CASP10; caspase 10 [EC:3.4.22.63]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K02581 NFKBIB; NF-kappa-B inhibitor beta
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K03173 TRAF2; TNF receptor-associated factor 2
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K03175 TRAF6; TNF receptor-associated factor 6
K04416 MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K10030 IL8, CXCL8; interleukin 8
K03156 TNFA; tumor necrosis factor superfamily, member 2
K05406 IL12A; interleukin 12A
K05425 IL12B; interleukin 12B
K12671 CXCL10, IP10; C-X-C motif chemokine 10
K10652 TRIM25, EFP; tripartite motif-containing protein 25
K08601 CYLD, USLP2; ubiquitin thioesterase CYLD [EC:3.1.2.15]
K12170 RNF125; E3 ubiquitin-protein ligase RNF125 [EC:6.3.2.19]
K12159 ISG15; ubiquitin cross-reactive protein
K08339 ATG5; autophagy-related protein 5
K08336 ATG12; autophagy-related protein 12
K12653 NLRX1; NLR family member X1
K12654 TMEM173, MITA; transmembrane protein 173
K12655 OTUD5, DUBA; OTU domain-containing protein 5 [EC:3.1.2.15]
K12656 SIKE; suppressor of IKK-epsilon
K11594 DDX3X, bel; ATP-dependent RNA helicase [EC:3.6.4.13]
K09578 PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [EC:5.2.1.8]
K00863 E2.7.1.29, DAK1, DAK2; dihydroxyacetone kinase [EC:2.7.1.29]
|
04623 Cytosolic DNA-sensing pathway [PATH:ko04623]
|
04650 Natural killer cell mediated cytotoxicity [PATH:ko04650]
|
04612 Antigen processing and presentation [PATH:ko04612]
|
04660 T cell receptor signaling pathway [PATH:ko04660]
|
04662 B cell receptor signaling pathway [PATH:ko04662]
|
04664 Fc epsilon RI signaling pathway [PATH:ko04664]
|
04666 Fc gamma R-mediated phagocytosis [PATH:ko04666]
|
04670 Leukocyte transendothelial migration [PATH:ko04670]
|
04672 Intestinal immune network for IgA production [PATH:ko04672]
|
04062 Chemokine signaling pathway [PATH:ko04062]
|
|
Endocrine system
|
04911 Insulin secretion [PATH:ko04911]
|
04910 Insulin signaling pathway [PATH:ko04910]
|
04920 Adipocytokine signaling pathway [PATH:ko04920]
|
K03156 TNFA; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K05141 TNFRSF1B, TNFR2; tumor necrosis factor receptor superfamily member 1B
K03173 TRAF2; TNF receptor-associated factor 2
K07203 FRAP; FKBP12-rapamycin complex-associated protein
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02581 NFKBIB; NF-kappa-B inhibitor beta
K05872 NFKBIE; NF-kappa-B inhibitor epsilon
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K04696 SOCS3, CIS3; suppressor of cytokine signaling 3
K16172 IRS1; insulin receptor substrate 1
K07187 IRS2_3_4; insulin receptor substrate 2/3/4
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K06259 CD36; CD36 antigen
K01897 ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]
K15013 ACSBG; long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]
K05424 LEP; leptin
K05062 LEPR; leptin receptor
K04447 JAK2; Janus kinase 2 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
K05228 POMC; proopiomelanocortin
K07198 PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
K07199 PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
K07200 PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
K05231 AGRP; agouti related protein
K05232 NPY; neuropeptide Y
K07202 PGC1; peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
K01596 E4.1.1.32, pckA, PEPCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K01084 G6PC; glucose-6-phosphatase [EC:3.1.3.9]
K07293 PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
K07294 NR1C1, PPARA; peroxisome proliferator-activated receptor alpha
K08524 NR2B1, RXRA; retinoid X receptor alpha
K08525 NR2B2, RXRB; retinoid X receptor beta
K08526 NR2B3, RXRG; retinoid X receptor gamma
K07296 ACDC; adiponectin
K07297 ADIPOR; adiponectin receptor
K07298 STK11, LKB1; serine/threonine-protein kinase 11
K07359 CAMKK; calcium/calmodulin-dependent protein kinase kinase [EC:2.7.11.17]
K08765 CPT1; carnitine O-palmitoyltransferase 1 [EC:2.3.1.21]
K07299 SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K07191 SLC2A4, GLUT4; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 4
|
03320 PPAR signaling pathway [PATH:ko03320]
|
04912 GnRH signaling pathway [PATH:ko04912]
|
04913 Ovarian Steroidogenesis [PATH:ko04913]
|
04915 Estrogen signaling pathway [PATH:ko04915]
|
04914 Progesterone-mediated oocyte maturation [PATH:ko04914]
|
04916 Melanogenesis [PATH:ko04916]
|
04614 Renin-angiotensin system [PATH:ko04614]
|
|
Circulatory system
|
|
Digestive system
|
|
Excretory system
|
|
Nervous system
|
|
Sensory system
|
|
Development
|
04320 Dorso-ventral axis formation [PATH:ko04320]
|
04360 Axon guidance [PATH:ko04360]
|
04380 Osteoclast differentiation [PATH:ko04380]
|
K05453 CSF1, MCSF; macrophage colony-stimulating factor 1
K05090 CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-binding protein 2
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04687 IFNG; interferon gamma
K05132 IFNGR1, CD119; interferon gamma receptor 1
K05133 IFNGR2; interferon gamma receptor 2
K11220 STAT1; signal transducer and activator of transcription 1
K04383 IL1A; interleukin 1 alpha
K04519 IL1B; interleukin 1 beta
K04386 IL1R1; interleukin 1 receptor type I
K03156 TNFA; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K05473 TNFSF11, RANKL; tumor necrosis factor ligand superfamily member 11
K05147 TNFRSF11A, RANK; tumor necrosis factor receptor superfamily member 11A
K05148 TNFRSF11B, OPG; tumor necrosis factor receptor superfamily member 11B
K03173 TRAF2; TNF receptor-associated factor 2
K03175 TRAF6; TNF receptor-associated factor 6
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
K05703 FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]
K04466 MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K09253 RELB; transcription factor RelB
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K04403 MAP3K7IP1, TAB1; TAK1-binding protein 1
K04404 MAP3K7IP2, TAB2; TAK1-binding protein 2
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K04735 RELA; transcription factor p65
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K05415 IFNB; interferon beta
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04433 MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04431 MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K04379 FOS; proto-oncogene protein c-fos
K09029 FOSB; protein FosB
K09030 FOSL2; fos-like antigen 2
K04502 FOSL1; fos-like antigen 1
K04448 JUN; transcription factor AP-1
K04449 JUND; transcription factor jun-D
K09028 JUNB; transcription factor jun-B
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K08008 NOX, GP91; NADPH oxidase
K08009 CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
K08010 NCF2, P67PHOX; neutrophil cytosolic factor 2
K08011 NCF1, P47PHOX; neutrophil cytosolic factor 1
K08012 NCF4, P40PHOX; neutrophil cytosolic factor 4
K07370 BTK; Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]
K07364 TEC; tyrosine-protein kinase Tec [EC:2.7.10.2]
K14377 OSCAR; osteoclast-associated immunoglobulin-like receptor
K06512 LILR; leukocyte immunoglobulin-like receptor
K06498 FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
K06472 FCGR2A, CD32; low affinity immunoglobulin gamma Fc region receptor II-a
K12560 FCGR2B, CD32; low affinity immunoglobulin gamma Fc region receptor II-b
K16824 FCGR2C, CD32; low affinity immunoglobulin gamma Fc region receptor II-c
K06463 FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
K14378 TREM2; triggering receptor expressed on myeloid cells 2
K06551 SIRPA_B1_G; signal-regulatory protein alpha/beta1/gamma
K07992 TYROBP, DAP12; TYRO protein tyrosine kinase binding protein
K05855 SYK; spleen tyrosine kinase [EC:2.7.10.2]
K07371 BLNK; B-cell linker protein
K07361 LCP2; lymphocyte cytosolic protein 2
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K04348 PPP3C, CNA; protein phosphatase 3, catalytic subunit [EC:3.1.3.16]
K06268 PPP3R, CNB; protein phosphatase 3, regulatory subunit
K05869 CAMK4; calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]
K05870 CREB1; cyclic AMP-responsive element-binding protein 1
K09438 SPI1; transcription factor PU.1
K09455 MITF; microphthalmia-associated transcription factor
K01371 CTSK; cathepsin K [EC:3.4.22.38]
K14379 ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]
K04576 CALCR; calcitonin receptor
K06493 ITGB3; integrin beta 3
K08530 NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
K05130 IFNAR1; interferon receptor 1
K05131 IFNAR2; interferon receptor 2
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K11219 TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
K11221 STAT2; signal transducer and activator of transcription 2
K04693 IRF9, ISGF3G, P48; interferon regulatory factor 9
K04694 SOCS1, JAB; suppressor of cytokine signaling 1
K04696 SOCS3, CIS3; suppressor of cytokine signaling 3
K08091 GAB2; growth factor receptor bound protein 2-associated protein 2
K14380 FHL2; four and a half LIM domains protein 2
K08601 CYLD, USLP2; ubiquitin thioesterase CYLD [EC:3.1.2.15]
K14381 SQSTM1; sequestosome 1
|
|
Environmental adaptation
|
|
Human Diseases
|
|
Cancers
|
05200 Pathways in cancer [PATH:ko05200]
|
K06765 DCC; deleted in colorectal carcinoma
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K08733 APPL, DIP13A; DCC-interacting protein 13 alpha
K05689 CDHE, CDH1; cadherin 1, type 1, E-cadherin
K02105 CTNNB1; catenin beta 1
K05691 CTNNA; catenin alpha
K02157 AXIN1; axin 1
K04385 AXIN2; axin 2
K02085 APC; adenomatosis polyposis coli protein
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02620 TCF7; transcription factor 7
K04490 TCF7L1; transcription factor 7-like 1
K04491 TCF7L2; transcription factor 7-like 2
K04492 LEF1; lymphoid enhancer-binding factor 1
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K04377 MYC; Myc proto-oncogene protein
K04503 CCND1; cyclin D1
K03209 WNT1; wingless-type MMTV integration site family, member 1
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00408 WNT4; wingless-type MMTV integration site family, member 4
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00445 WNT6; wingless-type MMTV integration site family, member 6
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00714 WNT8; wingless-type MMTV integration site family, member 8
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01384 WNT11; wingless-type MMTV integration site family, member 11
K01558 WNT16; wingless-type MMTV integration site family, member 16
K02432 FZD1_7, fz; frizzled 1/7
K02235 FZD2; frizzled 2
K02329 FZD3; frizzled 3
K02354 FZD4, fz4; frizzled 4
K02375 FZD5_8, fz2; frizzled 5/8
K02376 FZD6; frizzled 6
K02842 FZD9_10; frizzled 9/10
K02353 DVL; segment polarity protein dishevelled
K06237 COL4A; collagen, type IV, alpha
K05637 LAMA1_2; laminin, alpha 1/2
K06240 LAMA3_5; laminin, alpha 3/5
K06241 LAMA4; laminin, alpha 4
K05636 LAMB1; laminin, beta 1
K06243 LAMB2; laminin, beta 2
K06244 LAMB3; laminin, beta 3
K06245 LAMB4; laminin, beta 4
K05635 LAMC1; laminin, gamma 1
K06246 LAMC2; laminin, gamma 2
K06247 LAMC3; laminin, gamma 3
K05717 FN1; fibronectin 1
K06481 ITGA2; integrin alpha 2
K06476 ITGA2B; integrin alpha 2B
K06482 ITGA3; integrin alpha 3
K06485 ITGA6; integrin alpha 6
K06487 ITGAV; integrin alpha V
K05719 ITGB1; integrin beta 1
K05725 PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K09348 NKX3-1; homeobox protein Nkx-3.1
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04735 RELA; transcription factor p65
K11987 PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K13241 NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
K02161 BCL2; apoptosis regulator BCL-2
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K04570 BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
K03172 TRAF1; TNF receptor-associated factor 1
K03173 TRAF2; TNF receptor-associated factor 2
K03174 TRAF3; TNF receptor-associated factor 3
K09848 TRAF4; TNF receptor-associated factor 4
K09849 TRAF5; TNF receptor-associated factor 5
K03175 TRAF6; TNF receptor-associated factor 6
K07203 FRAP; FKBP12-rapamycin complex-associated protein
K02158 BAD; BCL2-antagonist of cell death
K07201 FOXO1; forkhead box protein O1
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
K04451 TP53, P53; tumor protein p53
K06624 CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
K06625 CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K08878 BCR1, BCR; breakpoint cluster region protein [EC:2.7.11.1]
K06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K04438 CRK, CRKII; proto-oncogene C-crk
K04707 CBL; E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
K11223 STAT5A; signal transducer and activator of transcription 5A
K11224 STAT5B; signal transducer and activator of transcription 5B
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
K11220 STAT1; signal transducer and activator of transcription 1
K05448 VEGFA; vascular endothelial growth factor A
K16858 VEGFB; vascular endothelial growth factor B
K16859 PGF; placenta growth factor
K05449 VEGFC_D; vascular endothelial growth factor C/D
K08774 TGFA; transforming growth factor, alpha
K04357 EGF; epidermal growth factor
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K05083 ERBB2, HER2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K04359 PDGFA_B; platelet derived growth factor A/B
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05459 IGF1; insulin-like growth factor 1
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K05461 KITLG; KIT ligand
K05091 KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05454 FLT3LG; fms-related tyrosine kinase 3 ligand
K05092 FLT3, FLK2; fms-related tyrosine kinase 3 [EC:2.7.10.1]
K05460 HGF; hepatocyte growth factor
K05099 MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K04358 FGF; fibroblast growth factor
K04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094 FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-binding protein 2
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS, KRAS2; GTPase KRas
K07828 NRAS; GTPase NRas
K08845 ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K04448 JUN; transcription factor AP-1
K04379 FOS; proto-oncogene protein c-fos
K01388 MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K01398 MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
K01403 MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
K10030 IL8, CXCL8; interleukin 8
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
K09288 CCDC6, PTC; coiled-coil domain-containing protein 6
K09289 NCOA4, PTC3; nuclear receptor coactivator 4
K03176 NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K09290 TPM3; tropomyosin 3
K09291 TPR; nucleoprotein TPR
K09292 TFG; protein TFG
K09850 RASSF1; Ras association domain-containing protein 1
K08015 RASSF5, RAPL; Ras association domain-containing protein 5
K04411 STK4, MST1; serine/threonine kinase 4
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K02677 CPKC; classical protein kinase C [EC:2.7.11.13]
K08732 RALGDS; ral guanine nucleotide dissociation stimulator
K07834 RALA; Ras-related protein Ral-A
K07835 RALB; Ras-related protein Ral-B
K08773 RALBP1; RalA-binding protein 1
K04393 CDC42; cell division control protein 42
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K04513 RHOA; Ras homolog gene family, member A
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K09293 PAX8; paired box protein 8
K08530 NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
K08524 NR2B1, RXRA; retinoid X receptor alpha
K08525 NR2B2, RXRB; retinoid X receptor beta
K08526 NR2B3, RXRG; retinoid X receptor gamma
K08528 NR1B2, RARB; retinoic acid receptor beta
K04504 NR1C2, PPARD; peroxisome proliferator-activated receptor delta
K10056 JUP; junction plakoglobin
K10055 ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
K10054 PML, TRIM19; probable transcription factor PML
K08527 NR1B1, RARA; retinoic acid receptor alpha
K08367 RUNX1, AML1; runt-related transcription factor 1
K10053 RUNX1T1, CBFA2T1; runt-related transcription factor 1; translocated to, 1
K09438 SPI1; transcription factor PU.1
K09055 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
K05066 CSF2RA, GMCSFR; granulocyte-macrophage colony-stimulating factor receptor alpha
K05061 CSF3R; granulocyte colony-stimulating factor receptor
K05090 CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K05405 IL6; interleukin 6
K06621 CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
K06620 E2F1_3; E2F transcription factor 1/3
K09389 E2F2; E2F transcription factor 2
K04453 MAX; Max protein
K16063 PIAS2; E3 SUMO-protein ligase PIAS2 [EC:6.3.2.-]
K04685 CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K02219 CKS1; cyclin-dependent kinase regulatory subunit CKS1
K03875 SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06626 CCNE; cyclin E
K06618 RB1; retinoblastoma-associated protein
K09455 MITF; microphthalmia-associated transcription factor
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04500 SMAD2_3; mothers against decapentaplegic homolog 2/3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K04462 EVI1; ecotropic virus integration site 1 protein
K04496 CTBP; C-terminal binding protein
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K08734 MLH1; DNA mismatch repair protein MLH1
K08735 MSH2; DNA mismatch repair protein MSH2
K08736 MSH3; DNA mismatch repair protein MSH3
K08737 MSH6; DNA mismatch repair protein MSH6
K02159 BAX; apoptosis regulator BAX
K08775 BRCA2, FANCD1; breast cancer 2 susceptibility protein
K04482 RAD51; DNA repair protein RAD51
K04389 TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
K02373 FADD; FAS-associated death domain protein
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04726 BID; BH3 interacting domain death agonist
K08738 CYC; cytochrome c
K03871 VHL; von Hippel-Lindau disease tumor supressor
K03872 TCEB1; transcription elongation factor B, polypeptide 1
K03873 TCEB2; transcription elongation factor B, polypeptide 2
K03868 RBX1, ROC1; RING-box protein 1
K03870 CUL2; cullin 2
K09592 EGLN, HPH; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.-]
K01679 E4.2.1.2B, fumC; fumarate hydratase, class II [EC:4.2.1.2]
K08268 HIF1A; hypoxia-inducible factor 1 alpha
K09095 HIF2A, EPAS1; hypoxia-inducible factor 2 alpha
K09097 ARNT; aryl hydrocarbon receptor nuclear translocator
K15589 ARNT2; aryl hydrocarbon receptor nuclear translocator 2
K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K07299 SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K11988 SHH; sonic hedgehog
K06225 PTCH1; patched 1
K06226 SMO; smoothened
K06227 COS2; costal 2
K06228 FU; fused [EC:2.7.11.1]
K06229 SUFU; suppressor of fused
K16797 GLI1; zinc finger protein GLI1
K16798 GLI2; zinc finger protein GLI2
K06230 GLI3; zinc finger protein GLI3
K04662 BMP2_4; bone morphogenetic protein 2/4
K06231 HHIP; hedgehog interacting protein
K11101 PTCH2; patched 2
K08557 NR3C4, AR; androgen receptor
K04079 htpG, HSP90A; molecular chaperone HtpG
K09487 HSP90B, TRA1; heat shock protein 90kDa beta
K01351 KLK3; semenogelase [EC:3.4.21.77]
|
05202 Transcriptional misregulation in cancers [PATH:ko05202]
|
05205 Proteoglycans in cancer [PATH:ko05205]
|
05204 Chemical carcinogenesis [PATH:ko05204]
|
05203 Viral carcinogenesis [PATH:ko05203]
|
K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
K02833 HRAS; GTPase HRas
K07827 KRAS, KRAS2; GTPase KRas
K07828 NRAS; GTPase NRas
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K05870 CREB1; cyclic AMP-responsive element-binding protein 1
K04450 ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
K04374 ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09047 CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
K09049 ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
K10610 DDB1; DNA damage-binding protein 1
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K06630 YWHAE; 14-3-3 protein epsilon
K16198 YWHAG_H; 14-3-3 protein gamma/eta
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
K11223 STAT5A; signal transducer and activator of transcription 5A
K11224 STAT5B; signal transducer and activator of transcription 5B
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K08665 HPN; hepsin (transmembrane protease, serine 1) [EC:3.4.21.-]
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K04735 RELA; transcription factor p65
K09254 REL; c-Rel proto-oncogene protein
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04451 TP53, P53; tumor protein p53
K06626 CCNE; cyclin E
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K12496 EGR2; early growth response protein 2
K12497 EGR3; early growth response protein 3
K15041 VDAC3; voltage-dependent anion channel protein 3
K03159 TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3
K15413 SP100; nuclear autoantigen Sp-100
K12886 HNRNPK; heterogeneous nuclear ribonucleoprotein K
K06625 CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K11594 DDX3X, bel; ATP-dependent RNA helicase [EC:3.6.4.13]
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K11252 H2B; histone H2B
K11254 H4; histone H4
K02159 BAX; apoptosis regulator BAX
K04364 GRB2; growth factor receptor-binding protein 2
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K02087 CDK1, CDC2; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K03120 TBP, tbp; transcription initiation factor TFIID TATA-box-binding protein
K11838 USP7, UBP15; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.1.2.15]
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
K06053 RBPSUH, RBPJK; recombining binding protein suppressor of hairless
K06063 SNW1, SKIIP, SKIP; SNW domain-containing protein 1
K03141 TFIIH1, GTF2H1, TFB1; transcription initiation factor TFIIH subunit 1
K03142 TFIIH2, GTF2H2, SSL1; transcription initiation factor TFIIH subunit 2
K03143 TFIIH3, GTF2H3, TFB4; transcription initiation factor TFIIH subunit 3
K03144 TFIIH4, GTF2H4, TFB2; transcription initiation factor TFIIH subunit 4
K03136 TFIIE1, GTF2E1, TFA1, tfe; transcription initiation factor TFIIE subunit alpha
K03137 TFIIE2, GTF2E2, TFA2; transcription initiation factor TFIIE subunit beta
K15979 SND1; staphylococcal nuclease domain-containing protein 1
K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K03124 TFIIB, GTF2B, SUA7, tfb; transcription initiation factor TFIIB
K04503 CCND1; cyclin D1
K10151 CCND2; cyclin D2
K10152 CCND3; cyclin D3
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K06627 CCNA; cyclin A
K03875 SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K16174 MRPS18B, MRPS18-2; 28S ribosomal protein S18b, mitochondrial
K03172 TRAF1; TNF receptor-associated factor 1
K03173 TRAF2; TNF receptor-associated factor 2
K03174 TRAF3; TNF receptor-associated factor 3
K09849 TRAF5; TNF receptor-associated factor 5
K11218 JAK3; Janus kinase 3 [EC:2.7.10.2]
K05854 LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
K05855 SYK; spleen tyrosine kinase [EC:2.7.10.2]
K02146 ATPeVAC39, ATP6D; V-type H+-transporting ATPase subunit AC39 [EC:3.6.3.14]
K10587 UBE3A, E6AP; ubiquitin-protein ligase E3 A [EC:6.3.2.19]
K12076 DLG1; disks large protein 1
K16175 SCRIB; protein scribble
K05760 PXN; paxillin
K14021 BAK, BAK1; Bcl-2 homologous antagonist/killer
K05411 IRF3; interferon regulatory factor 3
K03062 PSMC1, RPT2; 26S proteasome regulatory subunit T2
K06618 RB1; retinoblastoma-associated protein
K04681 RBL1; retinoblastoma-like protein 1
K16332 RBL2; retinoblastoma-like protein 2
K06624 CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
K10691 UBR4, ZUBR1; E3 ubiquitin-protein ligase UBR4 [EC:6.3.2.19]
K04448 JUN; transcription factor AP-1
K11643 CHD4, MI2B; chromodomain-helicase-DNA-binding protein 4 [EC:3.6.4.12]
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K11404 HDAC3; histone deacetylase 3 [EC:3.5.1.98]
K11406 HDAC4_5; histone deacetylase 4/5 [EC:3.5.1.98]
K11407 HDAC6_10; histone deacetylase 6/10 [EC:3.5.1.98]
K11408 HDAC7; histone deacetylase 7 [EC:3.5.1.98]
K11405 HDAC8; histone deacetylase 8 [EC:3.5.1.98]
K11409 HDAC9; histone deacetylase 9 [EC:3.5.1.98]
K11418 HDAC11; histone deacetylase 11 [EC:3.5.1.98]
K00873 PK, pyk; pyruvate kinase [EC:2.7.1.40]
K04693 IRF9, ISGF3G, P48; interferon regulatory factor 9
K09504 DNAJA3; DnaJ homolog subfamily A member 3
K06062 PCAF, KAT2, GCN5; histone acetyltransferase [EC:2.3.1.48]
K03122 TFIIA1, GTF2A1, TOA1; transcription initiation factor TFIIA large subunit
K03123 TFIIA2, GTF2A2, TOA2; transcription initiation factor TFIIA small subunit
K04378 SRF; serum response factor
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K08053 RASA2, GAP1M; Ras GTPase-activating protein 2
K04393 CDC42; cell division control protein 42
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K04513 RHOA; Ras homolog gene family, member A
K05768 GSN; gelsolin
K05699 ACTN; actinin alpha
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K06621 CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
K04685 CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
K02216 CHK1; serine/threonine-protein kinase Chk1 [EC:2.7.11.1]
K03363 CDC20; cell division cycle 20, cofactor of APC complex
K06638 MAD1L; mitotic spindle assembly checkpoint protein MAD1
K15305 VAC14, TAX1BP2; vacuole morphology and inheritance protein 14
K15306 RANBP1; Ran-binding protein 1
K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
K09447 IRF7; interferon regulatory factor 7
K05060 IL6ST, GP130; interleukin 6 signal transducer
K04180 CCR5; C-C chemokine receptor type 5
K04183 CCR8; C-C chemokine receptor type 8
K04178 CCR3; C-C chemokine receptor type 3
K04179 CCR4; C-C chemokine receptor type 4
K04443 MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K02158 BAD; BCL2-antagonist of cell death
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K03990 C3; complement component 3
K06751 MHC1; major histocompatibility complex, class I
|
05210 Colorectal cancer [PATH:ko05210]
|
05212 Pancreatic cancer [PATH:ko05212]
|
05214 Glioma [PATH:ko05214]
|
05216 Thyroid cancer [PATH:ko05216]
|
05221 Acute myeloid leukemia [PATH:ko05221]
|
05220 Chronic myeloid leukemia [PATH:ko05220]
|
05217 Basal cell carcinoma [PATH:ko05217]
|
05218 Melanoma [PATH:ko05218]
|
05211 Renal cell carcinoma [PATH:ko05211]
|
05219 Bladder cancer [PATH:ko05219]
|
05215 Prostate cancer [PATH:ko05215]
|
05213 Endometrial cancer [PATH:ko05213]
|
05222 Small cell lung cancer [PATH:ko05222]
|
K01522 FHIT; bis(5'-adenosyl)-triphosphatase [EC:3.6.1.29]
K08528 NR1B2, RARB; retinoic acid receptor beta
K08524 NR2B1, RXRA; retinoid X receptor alpha
K08525 NR2B2, RXRB; retinoid X receptor beta
K08526 NR2B3, RXRG; retinoid X receptor gamma
K04451 TP53, P53; tumor protein p53
K02161 BCL2; apoptosis regulator BCL-2
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K04377 MYC; Myc proto-oncogene protein
K04453 MAX; Max protein
K16063 PIAS2; E3 SUMO-protein ligase PIAS2 [EC:6.3.2.-]
K04685 CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K04503 CCND1; cyclin D1
K02219 CKS1; cyclin-dependent kinase regulatory subunit CKS1
K03875 SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06626 CCNE; cyclin E
K06618 RB1; retinoblastoma-associated protein
K06620 E2F1_3; E2F transcription factor 1/3
K09389 E2F2; E2F transcription factor 2
K06237 COL4A; collagen, type IV, alpha
K05637 LAMA1_2; laminin, alpha 1/2
K06240 LAMA3_5; laminin, alpha 3/5
K06241 LAMA4; laminin, alpha 4
K05636 LAMB1; laminin, beta 1
K06243 LAMB2; laminin, beta 2
K06244 LAMB3; laminin, beta 3
K06245 LAMB4; laminin, beta 4
K05635 LAMC1; laminin, gamma 1
K06246 LAMC2; laminin, gamma 2
K06247 LAMC3; laminin, gamma 3
K05717 FN1; fibronectin 1
K06481 ITGA2; integrin alpha 2
K06476 ITGA2B; integrin alpha 2B
K06482 ITGA3; integrin alpha 3
K06485 ITGA6; integrin alpha 6
K06487 ITGAV; integrin alpha V
K05719 ITGB1; integrin beta 1
K05725 PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K04570 BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
K03172 TRAF1; TNF receptor-associated factor 1
K03173 TRAF2; TNF receptor-associated factor 2
K03174 TRAF3; TNF receptor-associated factor 3
K09848 TRAF4; TNF receptor-associated factor 4
K09849 TRAF5; TNF receptor-associated factor 5
K03175 TRAF6; TNF receptor-associated factor 6
K11987 PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K13241 NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
|
05223 Non-small cell lung cancer [PATH:ko05223]
|
|
Immune diseases
|
|
Neurodegenerative diseases
|
|
Substance dependence
|
|
Cardiovascular diseases
|
|
Endocrine and metabolic diseases
|
|
Infectious diseases
|
05110 Vibrio cholerae infection [PATH:ko05110]
|
05111 Vibrio cholerae pathogenic cycle [PATH:ko05111]
|
05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
|
05130 Pathogenic Escherichia coli infection [PATH:ko05130]
|
05132 Salmonella infection [PATH:ko05132]
|
05131 Shigellosis [PATH:ko05131]
|
05133 Pertussis [PATH:ko05133]
|
05134 Legionellosis [PATH:ko05134]
|
05150 Staphylococcus aureus infection [PATH:ko05150]
|
05152 Tuberculosis [PATH:ko05152]
|
05100 Bacterial invasion of epithelial cells [PATH:ko05100]
|
05166 HTLV-I infection [PATH:ko05166]
|
05162 Measles [PATH:ko05162]
|
05164 Influenza A [PATH:ko05164]
|
05161 Hepatitis B [PATH:ko05161]
|
05160 Hepatitis C [PATH:ko05160]
|
K12473 LDLR; low-density lipoprotein receptor
K13885 SCARB1; scavenger receptor class B, member 1
K06508 CD81, TAPA1; CD81 antigen
K06087 CLDN; claudin
K06088 OCLN; occludin
K14216 OAS; 2'-5'-oligoadenylate synthetase
K01165 RNASEL; ribonuclease L
K12646 DDX58, RIG-I; ATP-dependent RNA helicase DDX58 [EC:3.6.3.14]
K12648 MAVS, IPS1; mitochondrial antiviral-signaling protein
K03174 TRAF3; TNF receptor-associated factor 3
K05410 TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
K07211 IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
K05411 IRF3; interferon regulatory factor 3
K09447 IRF7; interferon regulatory factor 7
K05415 IFNB; interferon beta
K05401 TLR3; toll-like receptor 3
K05842 TRIF; toll-like receptor adapter molecule 1
K03175 TRAF6; TNF receptor-associated factor 6
K02861 RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K16194 EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
K08860 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
K16196 EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]
K09444 IRF1; interferon regulatory factor 1
K03237 EIF2S1; translation initiation factor 2 subunit 1
K10030 IL8, CXCL8; interleukin 8
K04692 STAT3; signal transducer and activator of transcription 3
K14217 IFIT1; interferon-induced protein with tetratricopeptide repeats 1
K03250 EIF3E, INT6; translation initiation factor 3 subunit E
K05414 IFNA; interferon alpha
K05130 IFNAR1; interferon receptor 1
K05131 IFNAR2; interferon receptor 2
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K11219 TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
K11220 STAT1; signal transducer and activator of transcription 1
K11221 STAT2; signal transducer and activator of transcription 2
K04693 IRF9, ISGF3G, P48; interferon regulatory factor 9
K04696 SOCS3, CIS3; suppressor of cytokine signaling 3
K03456 PPP2R1; protein phosphatase 2 (formerly 2A), regulatory subunit A
K04354 PPP2R2; protein phosphatase 2 (formerly 2A), regulatory subunit B
K04382 PPP2C; protein phosphatase 2 (formerly 2A), catalytic subunit [EC:3.1.3.16]
K04706 PIAS1; E3 SUMO-protein ligase PIAS1 [EC:6.3.2.-]
K04357 EGF; epidermal growth factor
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-binding protein 2
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS, KRAS2; GTPase KRas
K07828 NRAS; GTPase NRas
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K08845 ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K12077 PDK1; pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02158 BAD; BCL2-antagonist of cell death
K04451 TP53, P53; tumor protein p53
K06625 CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K03156 TNFA; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
K03173 TRAF2; TNF receptor-associated factor 2
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K06698 PSME3; proteasome activator subunit 3 (PA28 gamma)
K08524 NR2B1, RXRA; retinoid X receptor alpha
K07294 NR1C1, PPARA; peroxisome proliferator-activated receptor alpha
K08536 NR1H3, LXRA; liver X receptor alpha
|
05168 Herpes simplex infection [PATH:ko05168]
|
K05468 LTA, TNFB; lymphotoxin alpha (TNF superfamily, member 1)
K05477 TNFSF14, LIGHT; tumor necrosis factor ligand superfamily member 14
K05152 TNFRSF14, HVEM; tumor necrosis factor receptor superfamily member 14
K03172 TRAF1; TNF receptor-associated factor 1
K03173 TRAF2; TNF receptor-associated factor 2
K03174 TRAF3; TNF receptor-associated factor 3
K09849 TRAF5; TNF receptor-associated factor 5
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K04448 JUN; transcription factor AP-1
K04379 FOS; proto-oncogene protein c-fos
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02581 NFKBIB; NF-kappa-B inhibitor beta
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K06081 PVRL1; poliovirus receptor-related protein 1
K06531 PVRL2; poliovirus receptor-related protein 2
K15411 PILRA; paired immunoglobulin-like type 2 receptor alpha
K07293 PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
K10159 TLR2; toll-like receptor 2
K04729 MYD88; myeloid differentiation primary response protein MyD88
K03175 TRAF6; TNF receptor-associated factor 6
K04403 MAP3K7IP1, TAB1; TAK1-binding protein 1
K04404 MAP3K7IP2, TAB2; TAK1-binding protein 2
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K10161 TLR9; toll-like receptor 9
K05401 TLR3; toll-like receptor 3
K05842 TRIF; toll-like receptor adapter molecule 1
K05411 IRF3; interferon regulatory factor 3
K09447 IRF7; interferon regulatory factor 7
K12646 DDX58, RIG-I; ATP-dependent RNA helicase DDX58 [EC:3.6.3.14]
K12647 IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13]
K12648 MAVS, IPS1; mitochondrial antiviral-signaling protein
K07211 IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
K05410 TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
K14624 CCL2, MCP1; C-C motif chemokine 2
K12499 CCL5; C-C motif chemokine 5
K03156 TNFA; tumor necrosis factor superfamily, member 2
K04519 IL1B; interleukin 1 beta
K05405 IL6; interleukin 6
K05406 IL12A; interleukin 12A
K05425 IL12B; interleukin 12B
K05433 IL15; interleukin 15
K05414 IFNA; interferon alpha
K14217 IFIT1; interferon-induced protein with tetratricopeptide repeats 1
K11838 USP7, UBP15; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.1.2.15]
K16194 EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
K08860 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
K16196 EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]
K03237 EIF2S1; translation initiation factor 2 subunit 1
K06269 PPP1C; protein phosphatase 1, catalytic subunit [EC:3.1.3.16]
K14216 OAS; 2'-5'-oligoadenylate synthetase
K01165 RNASEL; ribonuclease L
K03990 C3; complement component 3
K03994 C5; complement component 5
K15412 CFP; complement factor properdin
K03094 SKP1, CBF3D; S-phase kinase-associated protein 1
K02207 UBE2R, UBC3, CDC34; ubiquitin-conjugating enzyme E2 R [EC:6.3.2.19]
K03347 CUL1, CDC53; cullin 1
K03875 SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K15410 EEF1D; elongation factor 1-delta
K14840 NOP53, GLTSCR2; nucleolar protein 53
K11674 MCRS1, INO80Q; microspherule protein 1
K03006 RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
K15409 SRPK1; serine/threonine-protein kinase SRPK1 [EC:2.7.11.1]
K12890 SFRS1_9; splicing factor, arginine/serine-rich 1/9
K12891 SFRS2; splicing factor, arginine/serine-rich 2
K12892 SFRS3; splicing factor, arginine/serine-rich 3
K12893 SFRS4_5_6; splicing factor, arginine/serine-rich 4/5/6
K12896 SFRS7; splicing factor, arginine/serine-rich 7
K10054 PML, TRIM19; probable transcription factor PML
K15413 SP100; nuclear autoantigen Sp-100
K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K04451 TP53, P53; tumor protein p53
K02308 DAXX; death-associated protein 6
K02087 CDK1, CDC2; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K03097 CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]
K03115 CSNK2B; casein kinase II subunit beta
K14966 HCFC; host cell factor
K03120 TBP, tbp; transcription initiation factor TFIID TATA-box-binding protein
K03133 TAF9B, TAF9; transcription initiation factor TFIID subunit 9B
K03131 TAF6; transcription initiation factor TFIID subunit 6
K03130 TAF5; transcription initiation factor TFIID subunit 5
K03129 TAF4; transcription initiation factor TFIID subunit 4
K14650 TAF3; transcription initiation factor TFIID subunit 3
K03127 TAF13; transcription initiation factor TFIID subunit 13
K03134 TAF10; transcription initiation factor TFIID subunit 10
K15129 MED8; mediator of RNA polymerase II transcription subunit 8
K03121 TFII-I, GTF2I; transcription initiation factor TFII-I
K11299 HMGN1; high-mobility group nucleosome-binding domain-containing protein 1
K12881 THOC4, ALY; THO complex subunit 4
K14284 NXF1_2, TAP; nuclear RNA export factor 1/2
K15414 C1QBP; complement component 1 Q subcomponent-binding protein, mitochondrial
K12886 HNRNPK; heterogeneous nuclear ribonucleoprotein K
K06752 MHC2; major histocompatibility complex, class II
K06505 CD74, DHLAG; CD74 antigen
K05653 ABCB2, TAP1; ATP-binding cassette, subfamily B (MDR/TAP), member 2
K05654 ABCB3, TAP2; ATP-binding cassette, subfamily B (MDR/TAP), member 3
K06751 MHC1; major histocompatibility complex, class I
K05415 IFNB; interferon beta
K05130 IFNAR1; interferon receptor 1
K05131 IFNAR2; interferon receptor 2
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K11219 TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
K11220 STAT1; signal transducer and activator of transcription 1
K11221 STAT2; signal transducer and activator of transcription 2
K04693 IRF9, ISGF3G, P48; interferon regulatory factor 9
K04696 SOCS3, CIS3; suppressor of cytokine signaling 3
K04687 IFNG; interferon gamma
K05132 IFNGR1, CD119; interferon gamma receptor 1
K05133 IFNGR2; interferon gamma receptor 2
K04447 JAK2; Janus kinase 2 [EC:2.7.10.2]
K04389 TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
K03158 TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
K02373 FADD; FAS-associated death domain protein
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K08738 CYC; cytochrome c
K02296 ARNTL, BMAL1, CYC; aryl hydrocarbon receptor nuclear translocator-like protein 1
K02223 CLOCK, KAT13D; circadian locomoter output cycles kaput protein [EC:2.3.1.48]
K02633 PER; period circadian protein
|
05169 Epstein-Barr virus infection [PATH:ko05169]
|
K04012 CR2, CD21; complement receptor type 2
K03006 RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
K03010 RPB2, POLR2B; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
K03011 RPB3, POLR2C; DNA-directed RNA polymerase II subunit RPB3
K03008 RPB11, POLR2J; DNA-directed RNA polymerase II subunit RPB11
K03012 RPB4, POLR2D; DNA-directed RNA polymerase II subunit RPB4
K03015 RPB7, POLR2G; DNA-directed RNA polymerase II subunit RPB7
K03017 RPB9, POLR2I; DNA-directed RNA polymerase II subunit RPB9
K03013 RPB5, POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1
K03014 RPB6, POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2
K03016 RPB8, POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3
K03009 RPB12, POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4
K03007 RPB10, POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5
K03018 RPC1, POLR3A; DNA-directed RNA polymerase III subunit RPC1 [EC:2.7.7.6]
K03021 RPC2, POLR3B; DNA-directed RNA polymerase III subunit RPC2 [EC:2.7.7.6]
K03027 RPC40, POLR1C; DNA-directed RNA polymerases I and III subunit RPAC1
K03020 RPC19, POLR1D; DNA-directed RNA polymerases I and III subunit RPAC2
K03023 RPC82, POLR3C; DNA-directed RNA polymerase III subunit RPC3
K03026 RPC53, POLR3D; DNA-directed RNA polymerase III subunit RPC4
K14721 RPC37, POLR3E; DNA-directed RNA polymerase III subunit RPC5
K03025 RPC34, POLR3F; DNA-directed RNA polymerase III subunit RPC6
K03024 RPC31, POLR3G; DNA-directed RNA polymerase III subunit RPC7
K03022 RPC25, POLR3H; DNA-directed RNA polymerase III subunit RPC8
K03019 RPC11, POLR3K; DNA-directed RNA polymerase III subunit RPC10
K14290 XPO1, CRM1; exportin-1
K07936 RAN; GTP-binding nuclear protein Ran
K14317 NUP214, CAN; nuclear pore complex protein Nup214
K06751 MHC1; major histocompatibility complex, class I
K01242 CD38_157; NAD+ nucleosidase [EC:3.2.2.5]
K06477 SPN, CD43; sialophorin
K02087 CDK1, CDC2; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K15978 AKAP8L, HA95; A-kinase anchor protein 8-like protein
K03283 HSPA1_8; heat shock 70kDa protein 1/8
K04455 HSPB1; heat shock protein beta-1
K09543 HSPB2; heat shock protein beta-2
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K06630 YWHAE; 14-3-3 protein epsilon
K16198 YWHAG_H; 14-3-3 protein gamma/eta
K03124 TFIIB, GTF2B, SUA7, tfb; transcription initiation factor TFIIB
K15979 SND1; staphylococcal nuclease domain-containing protein 1
K03136 TFIIE1, GTF2E1, TFA1, tfe; transcription initiation factor TFIIE subunit alpha
K03137 TFIIE2, GTF2E2, TFA2; transcription initiation factor TFIIE subunit beta
K11406 HDAC4_5; histone deacetylase 4/5 [EC:3.5.1.98]
K06063 SNW1, SKIIP, SKIP; SNW domain-containing protein 1
K06065 NCOR2, SMRT; nuclear receptor co-repressor 2
K06053 RBPSUH, RBPJK; recombining binding protein suppressor of hairless
K09438 SPI1; transcription factor PU.1
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K13784 PTMA; prothymosin alpha
K06468 FCER2, CD23; Fc receptor, IgE, low affinity II
K08891 FGR, SRC2; tyrosine-protein kinase Fgr [EC:2.7.10.2]
K04377 MYC; Myc proto-oncogene protein
K04451 TP53, P53; tumor protein p53
K03120 TBP, tbp; transcription initiation factor TFIID TATA-box-binding protein
K06625 CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
K03061 PSMC2, RPT1; 26S proteasome regulatory subunit T1
K03062 PSMC1, RPT2; 26S proteasome regulatory subunit T2
K03063 PSMC4, RPT3; 26S proteasome regulatory subunit T3
K03064 PSMC6, RPT4; 26S proteasome regulatory subunit T4
K03065 PSMC3, RPT5; 26S proteasome regulatory subunit T5
K03066 PSMC5, RPT6; 26S proteasome regulatory subunit T6
K03028 PSMD2, RPN1; 26S proteasome regulatory subunit N1
K03032 PSMD1, RPN2; 26S proteasome regulatory subunit N2
K03033 PSMD3, RPN3; 26S proteasome regulatory subunit N3
K03035 PSMD12, RPN5; 26S proteasome regulatory subunit N5
K03036 PSMD11, RPN6; 26S proteasome regulatory subunit N6
K03037 PSMD6, RPN7; 26S proteasome regulatory subunit N7
K03038 PSMD7, RPN8; 26S proteasome regulatory subunit N8
K03039 PSMD13, RPN9; 26S proteasome regulatory subunit N9
K03029 PSMD4, RPN10; 26S proteasome regulatory subunit N10
K03030 PSMD14, RPN11, POH1; 26S proteasome regulatory subunit N11
K03031 PSMD8, RPN12; 26S proteasome regulatory subunit N12
K06691 RPN13; 26S proteasome regulatory subunit N13
K10881 SHFM1, DSS1; 26 proteasome complex subunit DSS1
K11838 USP7, UBP15; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.1.2.15]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K03097 CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]
K03115 CSNK2B; casein kinase II subunit beta
K06624 CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
K06627 CCNA; cyclin A
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06618 RB1; retinoblastoma-associated protein
K03875 SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K03172 TRAF1; TNF receptor-associated factor 1
K03173 TRAF2; TNF receptor-associated factor 2
K03174 TRAF3; TNF receptor-associated factor 3
K09849 TRAF5; TNF receptor-associated factor 5
K04466 MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K09253 RELB; transcription factor RelB
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K02861 RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K02581 NFKBIB; NF-kappa-B inhibitor beta
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K05872 NFKBIE; NF-kappa-B inhibitor epsilon
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K04730 IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
K03175 TRAF6; TNF receptor-associated factor 6
K04403 MAP3K7IP1, TAB1; TAK1-binding protein 1
K04404 MAP3K7IP2, TAB2; TAK1-binding protein 2
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K04432 MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
K04433 MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04430 MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
K04431 MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K04448 JUN; transcription factor AP-1
K04450 ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
K11218 JAK3; Janus kinase 3 [EC:2.7.10.2]
K01510 ENTPD1_3_8; apyrase [EC:3.6.1.5]
K03160 TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
K06256 CD44; CD44 antigen
K05718 ITGAL; integrin alpha L
K06492 CD58, LFA3; CD58 antigen
K06490 ICAM1; intercellular adhesion molecule 1
K07606 VIM; vimentin
K11859 TNFAIP3, A20; tumor necrosis factor, alpha-induced protein 3 [EC:3.-.-.-]
K02161 BCL2; apoptosis regulator BCL-2
K06856 IGH; immunoglobulin heavy chain
K05854 LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
K05855 SYK; spleen tyrosine kinase [EC:2.7.10.2]
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K06465 CD19; CD19 antigen
K10591 NEDD4, RSP5; E3 ubiquitin-protein ligase NEDD4 [EC:6.3.2.19]
K12646 DDX58, RIG-I; ATP-dependent RNA helicase DDX58 [EC:3.6.3.14]
K04687 IFNG; interferon gamma
K05410 TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
K05411 IRF3; interferon regulatory factor 3
K05443 IL10, CSIF; interleukin 10
K16194 EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
K08860 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
K16196 EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]
K05134 IL10RA; interleukin 10 receptor alpha
K05135 IL10RB; interleukin 10 receptor beta
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K11219 TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
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05146 Amoebiasis [PATH:ko05146]
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05144 Malaria [PATH:ko05144]
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05145 Toxoplasmosis [PATH:ko05145]
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05140 Leishmaniasis [PATH:ko05140]
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05142 Chagas disease (American trypanosomiasis) [PATH:ko05142]
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05143 African trypanosomiasis [PATH:ko05143]
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KEGG Orthology (KO)