Metabolism
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Genetic Information Processing
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Environmental Information Processing
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Membrane transport
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Signal transduction
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02020 Two-component system [PATH:ko02020]
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02022 Two-component system [BR:ko02022]
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04010 MAPK signaling pathway [PATH:ko04010]
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K04344 CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
K04849 CACNA1B; voltage-dependent calcium channel N type alpha-1B
K04850 CACNA1C; voltage-dependent calcium channel L type alpha-1C
K04851 CACNA1D; voltage-dependent calcium channel L type alpha-1D
K04852 CACNA1E; voltage-dependent calcium channel R type alpha-1E
K04853 CACNA1F; voltage-dependent calcium channel L type alpha-1F
K04854 CACNA1G; voltage-dependent calcium channel T type alpha-1G
K04855 CACNA1H; voltage-dependent calcium channel T type alpha-1H
K04856 CACNA1I; voltage-dependent calcium channel T type alpha-1I
K04857 CACNA1S; voltage-dependent calcium channel L type alpha-1S
K05315 CACNA1N; voltage-dependent calcium channel alpha 1, invertebrate
K04858 CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
K04859 CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
K04860 CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
K04861 CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
K05316 CACNA2DN; voltage-dependent calcium channel alpha-2/delta, invertebrate
K04862 CACNB1; voltage-dependent calcium channel beta-1
K04863 CACNB2; voltage-dependent calcium channel beta-2
K04864 CACNB3; voltage-dependent calcium channel beta-3
K04865 CACNB4; voltage-dependent calcium channel beta-4
K05317 CACNBN; voltage-dependent calcium channel beta, invertebrate
K04866 CACNG1; voltage-dependent calcium channel gamma-1
K04867 CACNG2; voltage-dependent calcium channel gamma-2
K04868 CACNG3; voltage-dependent calcium channel gamma-3
K04869 CACNG4; voltage-dependent calcium channel gamma-4
K04870 CACNG5; voltage-dependent calcium channel gamma-5
K04871 CACNG6; voltage-dependent calcium channel gamma-6
K04872 CACNG7; voltage-dependent calcium channel gamma-7
K04873 CACNG8; voltage-dependent calcium channel gamma-8
K04345 PKA; protein kinase A [EC:2.7.11.11]
K02677 CPKC; classical protein kinase C [EC:2.7.11.13]
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
K04347 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K04348 PPP3C, CNA; protein phosphatase 3, catalytic subunit [EC:3.1.3.16]
K06268 PPP3R, CNB; protein phosphatase 3, regulatory subunit
K04349 RASGRF1; Ras-specific guanine nucleotide-releasing factor 1
K12326 RASGRF2; Ras-specific guanine nucleotide-releasing factor 2
K04350 RASGRP1; RAS guanyl-releasing protein 1
K12361 RASGRP2; RAS guanyl-releasing protein 2
K12362 RASGRP3; RAS guanyl-releasing protein 3
K12363 RASGRP4; RAS guanyl-releasing protein 4
K08018 RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor (GEF) 2
K08052 NF1; neurofibromin 1
K04352 RASA1, RASGAP; Ras GTPase-activating protein 1
K08053 RASA2, GAP1M; Ras GTPase-activating protein 2
K04353 RAP1A; Ras-related protein Rap-1A
K07836 RAP1B; Ras-related protein Rap-1B
K02582 NGFB; nerve growth factor, beta
K04355 BDNF; brain-derived neurotrophic factor
K04356 NTF3; neurotrophin 3
K12457 NTF4; neurotrophin 4
K04357 EGF; epidermal growth factor
K04358 FGF; fibroblast growth factor
K04359 PDGFA_B; platelet derived growth factor A/B
K03176 NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K04360 NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094 FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
K05095 FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-binding protein 2
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS, KRAS2; GTPase KRas
K07828 NRAS; GTPase NRas
K07829 RRAS; Ras-related protein R-Ras
K07830 RRAS2, TC21; Ras-related protein R-Ras2
K07831 MRAS; Ras-related protein M-Ras
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04367 MOS; proto-oncogene serine/threonine-protein kinase mos [EC:2.7.11.1]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04370 MP1, MAP2K1IP1; mitogen-activated protein kinase kinase 1 interacting protein 1
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K04372 MKNK, MNK; MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]
K04373 RPS6KA, RSK2; p90 ribosomal S6 kinase [EC:2.7.11.1]
K04374 ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
K04375 ELK1; ETS domain-containing protein Elk-1
K04376 ELK4, SAP1; ETS domain-containing protein Elk-4
K04377 MYC; Myc proto-oncogene protein
K04378 SRF; serum response factor
K04379 FOS; proto-oncogene protein c-fos
K04380 MAPT, TAU; microtubule-associated protein tau
K04381 STMN1; stathmin
K16342 PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]
K03156 TNFA; tumor necrosis factor superfamily, member 2
K04383 IL1A; interleukin 1 alpha
K04519 IL1B; interleukin 1 beta
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K03158 TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
K04386 IL1R1; interleukin 1 receptor type I
K04387 IL1R2; interleukin 1 receptor type II
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04389 TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
K04391 CD14; CD14 antigen
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K04393 CDC42; cell division control protein 42
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K03173 TRAF2; TNF receptor-associated factor 2
K02308 DAXX; death-associated protein 6
K03175 TRAF6; TNF receptor-associated factor 6
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04403 MAP3K7IP1, TAB1; TAK1-binding protein 1
K04404 MAP3K7IP2, TAB2; TAK1-binding protein 2
K04405 SITPEC, ECSIT; evolutionarily conserved signaling intermediate in Toll pathways
K04406 MAP4K3, GLK; mitogen-activated protein kinase kinase kinase kinase 3 [EC:2.7.11.1]
K04407 MAP4K4, HGK; mitogen-activated protein kinase kinase kinase kinase 4 [EC:2.7.11.1]
K04408 MAP4K1, HPK1; mitogen-activated protein kinase kinase kinase kinase 1 [EC:2.7.11.1]
K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
K04410 PAK2; p21-activated kinase 2 [EC:2.7.11.1]
K04411 STK4, MST1; serine/threonine kinase 4
K04412 STK3, MST2; serine/threonine kinase 3
K04414 MAP4K2, GCK; mitogen-activated protein kinase kinase kinase kinase 2 [EC:2.7.11.1]
K04415 MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8 [EC:2.7.11.25]
K04416 MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
K04419 MAP3K11, MLK3; mitogen-activated protein kinase kinase kinase 11 [EC:2.7.11.25]
K04420 MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2 [EC:2.7.11.25]
K04421 MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]
K04422 MAP3K13, LZK; mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25]
K04423 MAP3K12, MUK; mitogen-activated protein kinase kinase kinase 12 [EC:2.7.11.25]
K04424 ZAK, MLTK; sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25]
K04425 MAP3K6, ASK2; mitogen-activated protein kinase kinase kinase 6 [EC:2.7.11.25]
K04426 MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K04428 MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25]
K04429 TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]
K04430 MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
K04431 MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04432 MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
K04433 MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
K04434 MAPK8IP1, JIP1; mitogen-activated protein kinase 8 interacting protein 1
K04435 MAPK8IP2, JIP2; mitogen-activated protein kinase 8 interacting protein 2
K04436 MAPK8IP3, JIP3; mitogen-activated protein kinase 8 interacting protein 3
K04437 FLNA; filamin
K04438 CRK, CRKII; proto-oncogene C-crk
K04439 ARRB; beta-arrestin
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04442 MAPKAPK5, PRAK; mitogen-activated protein kinase-activated protein kinase 5 [EC:2.7.11.1]
K04443 MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
K04444 MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]
K04445 MSK1, RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
K16510 MSK2, RPS6KA4; ribosomal protein S6 kinase alpha-4 [EC:2.7.11.1]
K05866 CDC25B; cell division cycle 25B [EC:3.1.3.48]
K04448 JUN; transcription factor AP-1
K04449 JUND; transcription factor jun-D
K04450 ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
K04451 TP53, P53; tumor protein p53
K04452 DDIT3, GADD153; DNA damage-inducible transcript 3
K04453 MAX; Max protein
K04454 MEF2C; MADS-box transcription enhancer factor 2C
K04455 HSPB1; heat shock protein beta-1
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04457 PPM1A, PP2CA; protein phosphatase 1A (formerly 2C) [EC:3.1.3.16]
K04458 PTP; protein-tyrosine phosphatase [EC:3.1.3.48]
K04459 DUSP, MKP; dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]
K04460 PPP5C, PP5; protein phosphatase 5 [EC:3.1.3.16]
K04461 PPM1B, PP2CB; protein phosphatase 1B (formerly 2C) [EC:3.1.3.16]
K03283 HSPA1_8; heat shock 70kDa protein 1/8
K04462 EVI1; ecotropic virus integration site 1 protein
K04463 MAP2K5, MEK5; mitogen-activated protein kinase kinase 5 [EC:2.7.12.2]
K04464 MAPK7, ERK5; mitogen-activated protein kinase 7 [EC:2.7.11.24]
K04465 NR4A1, HMR; nuclear receptor subfamily 4 group A member 1
K04466 MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04468 NLK; nemo like kinase [EC:2.7.11.24]
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04735 RELA; transcription factor p65
K09253 RELB; transcription factor RelB
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04013 MAPK signaling pathway - fly [PATH:ko04013]
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04011 MAPK signaling pathway - yeast [PATH:ko04011]
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04012 ErbB signaling pathway [PATH:ko04012]
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04310 Wnt signaling pathway [PATH:ko04310]
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04330 Notch signaling pathway [PATH:ko04330]
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04340 Hedgehog signaling pathway [PATH:ko04340]
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04350 TGF-beta signaling pathway [PATH:ko04350]
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K04657 CHRD; chordin
K04658 NOG; noggin
K16857 THBS1; thrombospondin 1
K04660 DCN; decorin
K04668 LEFTY; left-right determination factor
K04661 FST; follistatin
K04662 BMP2_4; bone morphogenetic protein 2/4
K04663 BMP5; bone morphogenetic protein 5
K16620 BMP6; bone morphogenetic protein 6
K16621 BMP7; bone morphogenetic protein 7
K16622 BMP8; bone morphogenetic protein 8
K04664 GDF5_6_7; growth differentiation factor 5/6/7
K04665 AMH; anti-mullerian hormone
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04667 INHB; inhibin, beta
K04666 NODAL; nodal
K04671 BMPR2; bone morphogenetic protein receptor type-2 [EC:2.7.11.30]
K04672 AMHR2; anti-mullerian hormone receptor type-2 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04670 ACVR2A; activin receptor type-2A [EC:2.7.11.30]
K13596 ACVR2B; activin receptor type-2B [EC:2.7.11.30]
K04673 BMPR1A, ALK3; bone morphogenetic protein receptor type-1A [EC:2.7.11.30]
K13578 BMPR1B, ALK6; bone morphogenetic protein receptor type-1B [EC:2.7.11.30]
K04675 ACVR1, ALK2; activin receptor type-1 [EC:2.7.11.30]
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K13567 ACVR1B, ALK4; activin receptor type-1B [EC:2.7.11.30]
K10162 BAMBI; BMP and activin membrane-bound inhibitor
K04676 SMAD1; mothers against decapentaplegic homolog 1
K16790 SMAD5; mothers against decapentaplegic homolog 5
K16791 SMAD9, SMAD8; mothers against decapentaplegic homolog 9
K04500 SMAD2_3; mothers against decapentaplegic homolog 2/3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K04677 SMAD6_7; mothers against decapentaplegic homolog 6/7
K04678 SMURF; E3 ubiquitin ligase SMURF1/2 [EC:6.3.2.19]
K04679 MADHIP, SARA; MAD, mothers against decapentaplegic interacting protein
K04680 ID; DNA-binding protein inhibitor ID
K04681 RBL1; retinoblastoma-like protein 1
K04682 E2F4_5; E2F transcription factor 4/5
K04683 TFDP1; transcription factor Dp-1
K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K04684 SP1; transcription factor Sp1
K04377 MYC; Myc proto-oncogene protein
K04685 CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
K04686 PITX2; paired-like homeodomain transcription factor 2
K03868 RBX1, ROC1; RING-box protein 1
K03347 CUL1, CDC53; cullin 1
K03094 SKP1, CBF3D; S-phase kinase-associated protein 1
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K04687 IFNG; interferon gamma
K03156 TNFA; tumor necrosis factor superfamily, member 2
K04513 RHOA; Ras homolog gene family, member A
K04514 ROCK; Rho-associated protein kinase [EC:2.7.11.1]
K03456 PPP2R1; protein phosphatase 2 (formerly 2A), regulatory subunit A
K04382 PPP2C; protein phosphatase 2 (formerly 2A), catalytic subunit [EC:3.1.3.16]
K04688 RPS6KB; p70 ribosomal S6 kinase [EC:2.7.11.1]
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04390 Hippo signaling pathway [PATH:ko04390]
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K16681 CRB; protein crumbs
K04237 PARD3; partitioning defective protein 3
K06093 PARD6; partitioning defective protein 6
K06069 APKC; atypical protein kinase C [EC:2.7.11.13]
K06092 INADL, PATJ; InaD-like protein
K06091 MPP5, PALS1; MAGUK p55 subfamily member 5
K16819 AMOT; angiomotin
K16687 YAP1, Yki; protein yorkie
K16820 WWTR1, TAZ; WW domain-containing transcription regulator protein 1
K05689 CDHE, CDH1; cadherin 1, type 1, E-cadherin
K16682 AJUBA, LIMD1, WTIP; LIM domain-containing protein
K16684 NF2; merlin
K16685 WWC1; protein KIBRA
K16821 FRMD1; FERM domain-containing protein 1
K16822 FRMD6; FERM domain-containing protein 6
K16686 SAV1, Sav; scaffold protein salvador
K04412 STK3, MST2; serine/threonine kinase 3
K09854 RASSF6; Ras association domain-containing protein 6
K09850 RASSF1; Ras association domain-containing protein 1
K04382 PPP2C; protein phosphatase 2 (formerly 2A), catalytic subunit [EC:3.1.3.16]
K03456 PPP2R1; protein phosphatase 2 (formerly 2A), regulatory subunit A
K04354 PPP2R2; protein phosphatase 2 (formerly 2A), regulatory subunit B
K08791 LATS1_2, Wts; serine/threonine-protein kinase LATS1/2 [EC:2.7.11.1]
K06685 MOB1, Mats; MOB kinase activator 1
K06269 PPP1C; protein phosphatase 1, catalytic subunit [EC:3.1.3.16]
K16823 TP53BP2, ASPP2; apoptosis-stimulating of p53 protein 2
K06094 LLGL; lethal(2) giant larvae protein
K16175 SCRIB; protein scribble
K12076 DLG1; disks large protein 1
K11828 DLG4, PSD95; discs large protein 4
K12075 DLG2_3; discs large protein 2/3
K08959 CSNK1D; casein kinase 1, delta [EC:2.7.11.1]
K08960 CSNK1E; casein kinase 1, epsilon [EC:2.7.11.1]
K03362 FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
K10148 TP73; tumor protein p73
K10132 BBC3, PUMA; BCL2-binding component 3
K09448 TEAD; transcriptional enhancer factor
K06827 CTGF; connective tissue growth factor
K16798 GLI2; zinc finger protein GLI2
K09782 AREG; amphiregulin
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K16144 AFP; alpha-fetoprotein
K06464 ITGB2; integrin beta 2
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04500 SMAD2_3; mothers against decapentaplegic homolog 2/3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K03982 SERPINE1, PAI1; plasminogen activator inhibitor-1
K04662 BMP2_4; bone morphogenetic protein 2/4
K04663 BMP5; bone morphogenetic protein 5
K16620 BMP6; bone morphogenetic protein 6
K16621 BMP7; bone morphogenetic protein 7
K16622 BMP8; bone morphogenetic protein 8
K04664 GDF5_6_7; growth differentiation factor 5/6/7
K04665 AMH; anti-mullerian hormone
K04673 BMPR1A, ALK3; bone morphogenetic protein receptor type-1A [EC:2.7.11.30]
K13578 BMPR1B, ALK6; bone morphogenetic protein receptor type-1B [EC:2.7.11.30]
K04671 BMPR2; bone morphogenetic protein receptor type-2 [EC:2.7.11.30]
K04676 SMAD1; mothers against decapentaplegic homolog 1
K04680 ID; DNA-binding protein inhibitor ID
K03209 WNT1; wingless-type MMTV integration site family, member 1
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00408 WNT4; wingless-type MMTV integration site family, member 4
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00445 WNT6; wingless-type MMTV integration site family, member 6
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00714 WNT8; wingless-type MMTV integration site family, member 8
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01384 WNT11; wingless-type MMTV integration site family, member 11
K01558 WNT16; wingless-type MMTV integration site family, member 16
K02432 FZD1_7, fz; frizzled 1/7
K02235 FZD2; frizzled 2
K02329 FZD3; frizzled 3
K02354 FZD4, fz4; frizzled 4
K02375 FZD5_8, fz2; frizzled 5/8
K02376 FZD6; frizzled 6
K02842 FZD9_10; frizzled 9/10
K02353 DVL; segment polarity protein dishevelled
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K06630 YWHAE; 14-3-3 protein epsilon
K16198 YWHAG_H; 14-3-3 protein gamma/eta
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02105 CTNNB1; catenin beta 1
K02085 APC; adenomatosis polyposis coli protein
K02157 AXIN1; axin 1
K04385 AXIN2; axin 2
K02620 TCF7; transcription factor 7
K04490 TCF7L1; transcription factor 7-like 1
K04491 TCF7L2; transcription factor 7-like 2
K04492 LEF1; lymphoid enhancer-binding factor 1
K04377 MYC; Myc proto-oncogene protein
K04503 CCND1; cyclin D1
K10151 CCND2; cyclin D2
K10152 CCND3; cyclin D3
K16796 SOX2; transcription factor SOX2 (SOX group B)
K05706 SNAI2, SLUG; snail 2
K05692 ACTB_G1; actin beta/gamma 1
K05691 CTNNA; catenin alpha
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04391 Hippo signaling pathway -fly [PATH:ko04391]
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04370 VEGF signaling pathway [PATH:ko04370]
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04630 Jak-STAT signaling pathway [PATH:ko04630]
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04064 NF-kappa B signaling pathway [PATH:ko04064]
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04668 TNF signaling pathway [PATH:ko04668]
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04066 HIF-1 signaling pathway [PATH:ko04066]
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04020 Calcium signaling pathway [PATH:ko04020]
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04070 Phosphatidylinositol signaling system [PATH:ko04070]
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04151 PI3K-Akt signaling pathway [PATH:ko04151]
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04150 mTOR signaling pathway [PATH:ko04150]
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04075 Plant hormone signal transduction [PATH:ko04075]
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Signaling molecules and interaction
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04030 G protein-coupled receptors [BR:ko04030]
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01020 Enzyme-linked receptors [BR:ko01020]
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04050 Cytokine receptors [BR:ko04050]
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03310 Nuclear receptors [BR:ko03310]
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04040 Ion channels [BR:ko04040]
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04031 GTP-binding proteins [BR:ko04031]
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04080 Neuroactive ligand-receptor interaction [PATH:ko04080]
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04060 Cytokine-cytokine receptor interaction [PATH:ko04060]
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K05505 CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
K05506 CXCL5_6, SCYB5_6; C-X-C motif chemokine 5/6
K10029 PPBP, CXCL7; platelet basic protein
K10030 IL8, CXCL8; interleukin 8
K05416 CXCL9; C-X-C motif chemokine 9
K12671 CXCL10, IP10; C-X-C motif chemokine 10
K12672 CXCL11, I-TAC; C-X-C motif chemokine 11
K10031 CXCL12; C-X-C motif chemokine 12
K10032 CXCL13; C-X-C motif chemokine 13
K10035 CXCL16; C-X-C motif chemokine 16
K10034 CXCL15; C-X-C motif chemokine 15
K05407 PF4, CXCL4; platelet factor 4
K10033 CXCL14, SCYB14; C-X-C motif chemokine 14
K05507 XCL, SCM1; C motif chemokine 1/2
K05508 CX3CL1, NTT; C-X3-C motif chemokine 1
K05514 CCLX; C-C motif chemokine, other
K14625 CCL20; C-C motif chemokine 20
K13072 CCL25; C-C motif chemokine 25
K05512 CCL19, ELC; C-C motif chemokine 19
K16062 CCL21, SLC; C-C motif chemokine 21
K14624 CCL2, MCP1; C-C motif chemokine 2
K12964 CCL4; C-C motif chemokine 4
K05408 CCL3; C-C motif chemokine 3
K16595 CCL13; C-C motif chemokine 13
K05509 CCL7; C-C motif chemokine 7
K12499 CCL5; C-C motif chemokine 5
K05511 CCL15_23; C-C motif chemokine 15/23
K16596 CCL8; C-C motif chemokine 8
K16597 CCL11; C-C motif chemokine 11
K05513 CCL28; C-C motif chemokine 28
K16598 CCL27; C-C motif chemokine 27
K05510 CCL6_9; C-C motif chemokine 6/9
K05405 IL6; interleukin 6
K05417 IL11; interleukin 11
K05418 OSM; oncostatin M
K05419 LIF; leukemia inhibitory factor
K05420 CNTF; ciliary neurotrophic factor
K05421 BSF3, CLC; B-cell stimulating factor 3
K05422 CTF1, CT1; cardiotrophin 1
K05423 CSF3, GCSF; granulocyte colony-stimulating factor
K05424 LEP; leptin
K05430 IL4; interleukin 4
K05435 IL13; interleukin 13
K05406 IL12A; interleukin 12A
K05425 IL12B; interleukin 12B
K05426 IL23A; interleukin 23, alpha subunit p19
K05427 CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
K04736 IL3; interleukin 3
K05428 IL5; interleukin 5
K05429 IL2; interleukin 2
K05431 IL7; interleukin 7
K05432 IL9; interleukin 9
K05433 IL15; interleukin 15
K05434 IL21; interleukin 21
K05436 TSLP; thymic stromal lymphopoietin
K05437 EPO; erythropoietin
K05438 GH; growth hormone
K05439 PRL; prolactin
K00431 TPO; thyroid peroxidase [EC:1.11.1.8]
K05450 PDGFC_D; platelet derived growth factor C/D
K04359 PDGFA_B; platelet derived growth factor A/B
K05448 VEGFA; vascular endothelial growth factor A
K16858 VEGFB; vascular endothelial growth factor B
K05449 VEGFC_D; vascular endothelial growth factor C/D
K05460 HGF; hepatocyte growth factor
K04357 EGF; epidermal growth factor
K05453 CSF1, MCSF; macrophage colony-stimulating factor 1
K05461 KITLG; KIT ligand
K05454 FLT3LG; fms-related tyrosine kinase 3 ligand
K05414 IFNA; interferon alpha
K05415 IFNB; interferon beta
K05440 IFNW1; interferon, omega 1
K05441 IFNK; interferon, kappa
K05442 IFNT1; interferon, tau-1
K04687 IFNG; interferon gamma
K05443 IL10, CSIF; interleukin 10
K05444 IL19_20_24; interleukin 19/20/24
K05445 IL22, IL-TIF; interleukin 22
K05447 IL28_29, IFNL; interleukin 28/29 (interferon, lambda)
K05446 IL26; interleukin 26
K05478 TNFSF15, VEGI; tumor necrosis factor ligand superfamily member 15
K04721 TNFSF10, TRAIL; tumor necrosis factor ligand superfamily member 10
K05473 TNFSF11, RANKL; tumor necrosis factor ligand superfamily member 11
K05474 TNFSF12, TWEAK; tumor necrosis factor ligand superfamily member 12
K03156 TNFA; tumor necrosis factor superfamily, member 2
K05468 LTA, TNFB; lymphotoxin alpha (TNF superfamily, member 1)
K03157 LTB, TNFC; lymphotoxin beta (TNF superfamily, member 3)
K05477 TNFSF14, LIGHT; tumor necrosis factor ligand superfamily member 14
K04389 TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
K03161 TNFSF5, CD40L; tumor necrosis factor ligand superfamily member 5
K05470 TNFSF7, CD70; tumor necrosis factor ligand superfamily member 7
K05471 TNFSF8, CD153; tumor necrosis factor ligand superfamily member 8
K05472 TNFSF9, CD137L; tumor necrosis factor ligand superfamily member 9
K05469 TNFSF4, OX40L; tumor necrosis factor ligand superfamily member 4
K05479 TNFSF18, GITRL; tumor necrosis factor ligand superfamily member 18
K05475 TNFSF13, APRIL; tumor necrosis factor ligand superfamily member 13
K05476 TNFSF13B, TNFSF20; tumor necrosis factor ligand superfamily member 13B
K05480 EDA; ectodysplasin-A
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04667 INHB; inhibin, beta
K04665 AMH; anti-mullerian hormone
K04662 BMP2_4; bone morphogenetic protein 2/4
K16621 BMP7; bone morphogenetic protein 7
K04664 GDF5_6_7; growth differentiation factor 5/6/7
K05489 IL17, CTLA8; interleukin 17
K05490 IL17B, CX1; interleukin 17B
K05493 IL17E, IL25; interleukin 17E
K04383 IL1A; interleukin 1 alpha
K04519 IL1B; interleukin 1 beta
K05482 IL18, IL1F4; interleukin 18
K05050 IL8RB, CXCR2; interleukin 8 receptor beta
K04175 IL8RA, CXCR1; interleukin 8 receptor alpha
K04188 CXCR3, GPR9; C-X-C chemokine receptor type 3
K04189 CXCR4; C-X-C chemokine receptor type 4
K04190 CXCR5, BLR1; C-X-C chemokine receptor type 5
K04191 CXCR6; C-X-C chemokine receptor type 6
K04304 CXCR7, RDC1; C-X-C chemokine receptor type 7
K04193 XCR1; XC chemokine receptor 1
K04192 CX3CR1; CX3C chemokine receptor 1
K04183 CCR8; C-C chemokine receptor type 8
K04181 CCR6; C-C chemokine receptor type 6
K04184 CCR9; C-C chemokine receptor type 9
K04179 CCR4; C-C chemokine receptor type 4
K04182 CCR7; C-C chemokine receptor type 7
K04177 CCR2; C-C chemokine receptor type 2
K04180 CCR5; C-C chemokine receptor type 5
K04176 CCR1; C-C chemokine receptor type 1
K04178 CCR3; C-C chemokine receptor type 3
K04185 CCR10; C-C chemokine receptor type 10
K05055 IL6R; interleukin 6 receptor
K05060 IL6ST, GP130; interleukin 6 signal transducer
K05056 IL11RA; interleukin 11 receptor alpha
K05058 LIFR; leukemia inhibitory factor receptor
K05057 OSMR; oncostatin M receptor
K05059 CNTFR; ciliary neurotrophic factor receptor
K05061 CSF3R; granulocyte colony-stimulating factor receptor
K05062 LEPR; leptin receptor
K05071 IL4R; interleukin 4 receptor
K05076 IL13RA1; interleukin 13 receptor alpha-1
K05063 IL12RB1; interleukin 12 receptor beta-1
K05064 IL12RB2; interleukin 12 receptor beta-2
K05065 IL23R; interleukin 23 receptor
K05066 CSF2RA, GMCSFR; granulocyte-macrophage colony-stimulating factor receptor alpha
K04738 CSF2RB, IL3RB; cytokine receptor common subunit beta
K04737 IL3RA; interleukin 3 receptor alpha
K05067 IL5RA; interleukin 5 receptor alpha
K05068 IL2RA, CD25; interleukin 2 receptor alpha
K05069 IL2RB; interleukin 2 receptor beta
K05070 IL2RG; interleukin 2 receptor gamma
K05072 IL7R; interleukin 7 receptor
K05073 IL9R; interleukin 9 receptor
K05074 IL15RA; interleukin 15 receptor alpha
K05075 IL21R; interleukin 21 receptor
K05078 TSLPR; thymic stromal-derived lymphopoietin receptor
K05079 EPOR; erythropoietin receptor
K05080 GHR; growth hormone receptor
K05081 PRLR; prolactin receptor
K05082 TPOR, MPL; thrombopoietin receptor
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05096 FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
K05098 KDR, VEGFR2; kinase insert domain protein receptor [EC:2.7.10.1]
K05097 FLT4, VEGFR3; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
K05099 MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K05090 CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K05091 KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05092 FLT3, FLK2; fms-related tyrosine kinase 3 [EC:2.7.10.1]
K05130 IFNAR1; interferon receptor 1
K05131 IFNAR2; interferon receptor 2
K05132 IFNGR1, CD119; interferon gamma receptor 1
K05133 IFNGR2; interferon gamma receptor 2
K05134 IL10RA; interleukin 10 receptor alpha
K05135 IL10RB; interleukin 10 receptor beta
K05136 IL20RA; interleukin 20 receptor alpha
K05137 IL20RB; interleukin 20 receptor beta
K05138 IL22RA1; interleukin 22 receptor alpha 1
K05139 IL22RA2; interleukin 22 receptor alpha 2
K05140 IL28RA; interleukin 28 receptor alpha
K04722 TNFRSF10, TRAILR; tumor necrosis factor receptor superfamily member 10
K05148 TNFRSF11B, OPG; tumor necrosis factor receptor superfamily member 11B
K05147 TNFRSF11A, RANK; tumor necrosis factor receptor superfamily member 11A
K05160 TNFRSF25; tumor necrosis factor receptor superfamily member 25
K05149 TNFRSF12A, FN14, TWEAKR; tumor necrosis factor receptor superfamily member 12A
K05157 TNFRSF21, DR6; tumor necrosis factor receptor superfamily member 21
K02583 NGFR; nerve growth factor receptor (TNFR superfamily member 16)
K05141 TNFRSF1B, TNFR2; tumor necrosis factor receptor superfamily member 1B
K03158 TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
K03159 TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3
K05152 TNFRSF14, HVEM; tumor necrosis factor receptor superfamily member 14
K05143 TNFRSF6B, DCR3; tumor necrosis factor receptor superfamily member 6B
K04390 TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
K03160 TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
K05144 TNFRSF7, CD27; tumor necrosis factor receptor superfamily member 7
K05145 TNFRSF8, CD30; tumor necrosis factor receptor superfamily member 8
K05146 TNFRSF9, CD137; tumor necrosis factor receptor superfamily member 9
K05142 TNFRSF4, OX40; tumor necrosis factor receptor superfamily member 4
K05154 TNFRSF18, GITR; tumor necrosis factor receptor superfamily member 18
K05153 TNFRSF17, BCMA; tumor necrosis factor receptor superfamily member 17
K05150 TNFRSF13B, TACI; tumor necrosis factor receptor superfamily member 13B
K05151 TNFRSF13C, BAFFR; tumor necrosis factor receptor superfamily member 13C
K05162 EDAR; tumor necrosis factor receptor superfamily member EDAR
K05163 EDA2R, TNFRSF27, XEDAR; tumor necrosis factor receptor superfamily member 27
K05155 TNFRSF19, TROY; tumor necrosis factor receptor superfamily member 19
K05156 TNFRSF19L, RELT; tumor necrosis factor receptor superfamily member 19-like
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04670 ACVR2A; activin receptor type-2A [EC:2.7.11.30]
K13596 ACVR2B; activin receptor type-2B [EC:2.7.11.30]
K04675 ACVR1, ALK2; activin receptor type-1 [EC:2.7.11.30]
K13567 ACVR1B, ALK4; activin receptor type-1B [EC:2.7.11.30]
K04672 AMHR2; anti-mullerian hormone receptor type-2 [EC:2.7.11.30]
K04671 BMPR2; bone morphogenetic protein receptor type-2 [EC:2.7.11.30]
K04673 BMPR1A, ALK3; bone morphogenetic protein receptor type-1A [EC:2.7.11.30]
K13578 BMPR1B, ALK6; bone morphogenetic protein receptor type-1B [EC:2.7.11.30]
K05164 IL17R; interleukin 17 receptor
K05165 IL17RB, IL17RH1; interleukin 17 receptor B
K04386 IL1R1; interleukin 1 receptor type I
K04723 IL1RAP; interleukin 1 receptor accessory protein
K04387 IL1R2; interleukin 1 receptor type II
K05173 IL18R1, IL1RRP; interleukin 18 receptor 1
K05174 IL18RAP, ACPL; interleukin 18 receptor accessory protein
|
04052 Cytokines [BR:ko04052]
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04512 ECM-receptor interaction [PATH:ko04512]
|
04514 Cell adhesion molecules (CAMs) [PATH:ko04514]
|
04516 Cell adhesion molecules and their ligands [BR:ko04516]
|
04090 CD Molecules [BR:ko04090]
|
04091 Glycan bindng proteins [BR:ko04091]
|
02042 Bacterial toxins [BR:ko02042]
|
|
Cellular Processes
|
|
Transport and catabolism
|
04144 Endocytosis [PATH:ko04144]
|
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04679 MADHIP, SARA; MAD, mothers against decapentaplegic interacting protein
K10054 PML, TRIM19; probable transcription factor PML
K04500 SMAD2_3; mothers against decapentaplegic homolog 2/3
K06503 TFRC, CD71; transferrin receptor
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K05096 FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
K05098 KDR, VEGFR2; kinase insert domain protein receptor [EC:2.7.10.1]
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094 FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
K05095 FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K05099 MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K03176 NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K05084 ERBB3, HER3; receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1]
K05085 ERBB4, HER4; receptor tyrosine-protein kinase erbB-4 [EC:2.7.10.1]
K05091 KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
K05090 CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K04357 EGF; epidermal growth factor
K01528 DNM; dynamin GTPase [EC:3.6.5.5]
K07941 ARF6; ADP-ribosylation factor 6
K00889 E2.7.1.68, PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
K13712 PIP5KL1; phosphatidylinositol-4-phosphate 5-kinase-like protein 1 [EC:2.7.1.68]
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K04644 CLTA, LCA; clathrin light chain A
K04645 CLTB, LCB; clathrin light chain B
K04646 CLTC; clathrin heavy chain
K11824 AP2A; AP-2 complex subunit alpha
K11825 AP2B1; AP-2 complex subunit beta-1
K11826 AP2M1; AP-2 complex subunit mu-1
K11827 AP2S1; AP-2 complex subunit sigma-1
K12469 EHD2; EH domain-containing protein 2
K04707 CBL; E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
K10591 NEDD4, RSP5; E3 ubiquitin-protein ligase NEDD4 [EC:6.3.2.19]
K13305 NEDD4L; E3 ubiquitin-protein ligase NEDD4-like [EC:6.3.2.19]
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
K03175 TRAF6; TNF receptor-associated factor 6
K11981 RNF41, NRDP1; E3 ubiquitin-protein ligase NRDP1 [EC:6.3.2.19]
K05632 AIP4, ITCH; atrophin-1 interacting protein 4 [EC:6.3.2.19]
K04678 SMURF; E3 ubiquitin ligase SMURF1/2 [EC:6.3.2.19]
K05633 AIP5, WWP1; atrophin-1 interacting protein 5 (WW domain containing E3 ubiquitin protein ligase 1) [EC:6.3.2.19]
K12470 SH3KBP1, CIN85; SH3 domain-containing kinase-binding protein 1
K11247 SH3GL; endophilin-A
K11248 SH3GLB; endophilin-B
K12471 EPN; epsin
K12472 EPS15; epidermal growth factor receptor substrate 15
K12473 LDLR; low-density lipoprotein receptor
K12474 LDLRAP1, ARH; low density lipoprotein receptor adapter protein 1
K12475 DAB2; disabled homolog 2
K04180 CCR5; C-C chemokine receptor type 5
K04175 IL8RA, CXCR1; interleukin 8 receptor alpha
K05050 IL8RB, CXCR2; interleukin 8 receptor beta
K04189 CXCR4; C-X-C chemokine receptor type 4
K03914 F2R, PAR1; coagulation factor II (thrombin) receptor
K04141 ADRB1; adrenergic receptor beta-1
K04142 ADRB2; adrenergic receptor beta-2
K04143 ADRB3; adrenergic receptor beta-3
K00909 GRK1_7; rhodopsin kinase [EC:2.7.11.14]
K00910 ADRBK, GRK; beta-adrenergic-receptor kinase [EC:2.7.11.15]
K08291 GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]
K04439 ARRB; beta-arrestin
K04677 SMAD6_7; mothers against decapentaplegic homolog 6/7
K13649 FOLR; folate receptor
K06278 CAV1; caveolin 1
K12958 CAV2; caveolin 2
K12959 CAV3; caveolin 3
K06751 MHC1; major histocompatibility complex, class I
K05068 IL2RA, CD25; interleukin 2 receptor alpha
K05069 IL2RB; interleukin 2 receptor beta
K05070 IL2RG; interleukin 2 receptor gamma
K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
K02833 HRAS; GTPase HRas
K04513 RHOA; Ras homolog gene family, member A
K03283 HSPA1_8; heat shock 70kDa protein 1/8
K09526 DNAJC6; DnaJ homolog subfamily C member 6
K11839 USP8, UBP5; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.1.2.15]
K11866 STAMBP, AMSH; STAM-binding protein [EC:3.1.2.15]
K07897 RAB7A; Ras-related protein Rab-7A
K12182 HGS, HRS, VPS27; hepatocyte growth factor-regulated tyrosine kinase substrate
K04705 STAM; signal transducing adaptor molecule
K12183 TSG101, STP22, VPS23; ESCRT-I complex subunit TSG101
K12186 FAM125; ESCRT-I complex subunit MVB12
K12187 MVB12; ESCRT-I complex subunit MVB12
K12184 VPS28; ESCRT-I complex subunit VPS28
K12185 VPS37; ESCRT-I complex subunit VPS37
K12188 SNF8, EAP30; ESCRT-II complex subunit VPS22
K12190 VPS36, EAP45; ESCRT-II complex subunit VPS36
K12189 VPS25, EAP20; ESCRT-II complex subunit VPS25
K12195 CHMP6, VPS20; charged multivesicular body protein 6
K12194 CHMP4, SNF7, VPS32; charged multivesicular body protein 4
K12193 VPS24, CHMP3; charged multivesicular body protein 3
K12191 CHMP2A; charged multivesicular body protein 2A
K12192 CHMP2B; charged multivesicular body protein 2B
K15053 CHMP7; charged multivesicular body protein 7
K12196 VPS4; vacuolar protein-sorting-associated protein 4
K12199 VTA1, LIP5; vacuolar protein sorting-associated protein VTA1
K12197 CHMP1, VPS46, DID2; charged multivesicular body protein 1
K12198 CHMP5, VPS60; charged multivesicular body protein 5
K12200 PDCD6IP, ALIX, RIM20; programmed cell death 6-interacting protein
K12476 EHD3; EH domain-containing protein 3
K12477 EHD4; EH domain-containing protein 4
K12478 EEA1; early endosome antigen 1
K07887 RAB5A; Ras-related protein Rab-5A
K07888 RAB5B; Ras-related protein Rab-5B
K07889 RAB5C; Ras-related protein Rab-5C
K12479 VPS45; vacuolar protein sorting-associated protein 45
K12480 RABEP1; Rab GTPase-binding effector protein 1
K12481 ZFYVE20; rabenosyn-5
K07879 RAB4A, RAB4; Ras-related protein Rab-4A
K12482 RUFY1, RABIP4; RUN and FYVE domain-containing protein 1
K12483 EHD1; EH domain-containing protein 1
K09235 RME1; zinc finger protein RME1
K07904 RAB11A; Ras-related protein Rab-11A
K07905 RAB11B; Ras-related protein Rab-11B
K12484 RAB11FIP1_2_5; Rab11 family-interacting protein 1/2/5
K12485 RAB11FIP3_4; Rab11 family-interacting protein 3/4
K07891 RAB22A; Ras-related protein Rab-22A
K07892 RAB31, RAB22B; Ras-related protein Rab-31
K04237 PARD3; partitioning defective protein 3
K06093 PARD6; partitioning defective protein 6
K06069 APKC; atypical protein kinase C [EC:2.7.11.13]
K04393 CDC42; cell division control protein 42
K12486 SMAP; stromal membrane-associated protein
K05737 GIT1; G protein-coupled receptor kinase interactor 1
K12487 GIT2; G protein-coupled receptor kinase interactor 2
K12488 ASAP; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein
K12489 ACAP; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein
K12490 ARAP; Arf-GAP, Rho-GAP domain, ANK repeat and PH domain-containing protein
K12491 AGAP1_2_3; Arf-GAP, GTPase, ANK repeat and PH domain-containing protein 1/2/3
K12492 ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1
K12493 ARFGAP2_3; ADP-ribosylation factor GTPase-activating protein 2/3
K12494 PSD; PH and SEC7 domain-containing protein
K12495 IQSEC; IQ motif and SEC7 domain-containing protein
|
04145 Phagosome [PATH:ko04145]
|
04142 Lysosome [PATH:ko04142]
|
04146 Peroxisome [PATH:ko04146]
|
04140 Regulation of autophagy [PATH:ko04140]
|
|
Cell motility
|
|
Cell growth and death
|
|
Cell communication
|
04510 Focal adhesion [PATH:ko04510]
|
04520 Adherens junction [PATH:ko04520]
|
K06081 PVRL1; poliovirus receptor-related protein 1
K06531 PVRL2; poliovirus receptor-related protein 2
K06592 PVRL3; poliovirus receptor-related protein 3
K06593 PVRL4; poliovirus receptor-related 4
K04237 PARD3; partitioning defective protein 3
K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
K06082 FARP2, FRG; FERM, RhoGEF and pleckstrin domain protein 2
K04393 CDC42; cell division control protein 42
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K05747 WAS; Wiskott-Aldrich syndrome protein
K16848 IQGAP1; Ras GTPase-activating-like protein IQGAP1
K05627 BAIAP2, IRSP53; BAI1-associated protein 2
K05753 WASF1; WAS protein family, member 1
K05748 WASF2; WAS protein family, member 2
K06083 WASF3; WAS protein family, member 3
K05702 AF6, MLLT4; afadin
K06084 LMO7, FBXO20; F-box protein 20
K06085 SSX2IP, ADIP; synovial sarcoma, X breakpoint 2 interacting protein
K06086 SORBS1, SH3D5, PONSIN, CAP; sorbin and SH3 domain containing 1
K05699 ACTN; actinin alpha
K05700 VCL; vinculin
K05701 TJP1, ZO1; tight junction protein 1
K05689 CDHE, CDH1; cadherin 1, type 1, E-cadherin
K05690 CTNND1; catenin (cadherin-associated protein), delta 1
K02105 CTNNB1; catenin beta 1
K05691 CTNNA; catenin alpha
K05692 ACTB_G1; actin beta/gamma 1
K04513 RHOA; Ras homolog gene family, member A
K05693 PTPRM; receptor-type tyrosine-protein phosphatase mu [EC:3.1.3.48]
K05694 PTPRB, PTPB; receptor-type tyrosine-protein phosphatase beta [EC:3.1.3.48]
K05695 PTPRF, LAR; receptor-type tyrosine-protein phosphatase F [EC:3.1.3.48]
K05696 PTPN1, PTP1B; tyrosine-protein phosphatase non-receptor type 1 [EC:3.1.3.48]
K05697 PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]
K05698 PTPRJ, DEP1; receptor-type tyrosine-protein phosphatase eta [EC:3.1.3.48]
K03097 CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]
K03115 CSNK2B; casein kinase II subunit beta
K02620 TCF7; transcription factor 7
K04490 TCF7L1; transcription factor 7-like 1
K04491 TCF7L2; transcription factor 7-like 2
K04492 LEF1; lymphoid enhancer-binding factor 1
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K04527 INSR; insulin receptor [EC:2.7.10.1]
K05099 MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K05083 ERBB2, HER2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05703 FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]
K05705 YES1; tyrosine-protein kinase Yes [EC:2.7.10.2]
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K05706 SNAI2, SLUG; snail 2
K05707 SNAI1; snail 1
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04500 SMAD2_3; mothers against decapentaplegic homolog 2/3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K04468 NLK; nemo like kinase [EC:2.7.11.24]
|
04530 Tight junction [PATH:ko04530]
|
04540 Gap junction [PATH:ko04540]
|
|
Organismal Systems
|
|
Immune system
|
|
Endocrine system
|
|
Circulatory system
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Digestive system
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Excretory system
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Nervous system
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Sensory system
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Development
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04320 Dorso-ventral axis formation [PATH:ko04320]
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04360 Axon guidance [PATH:ko04360]
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04380 Osteoclast differentiation [PATH:ko04380]
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K05453 CSF1, MCSF; macrophage colony-stimulating factor 1
K05090 CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-binding protein 2
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04687 IFNG; interferon gamma
K05132 IFNGR1, CD119; interferon gamma receptor 1
K05133 IFNGR2; interferon gamma receptor 2
K11220 STAT1; signal transducer and activator of transcription 1
K04383 IL1A; interleukin 1 alpha
K04519 IL1B; interleukin 1 beta
K04386 IL1R1; interleukin 1 receptor type I
K03156 TNFA; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K05473 TNFSF11, RANKL; tumor necrosis factor ligand superfamily member 11
K05147 TNFRSF11A, RANK; tumor necrosis factor receptor superfamily member 11A
K05148 TNFRSF11B, OPG; tumor necrosis factor receptor superfamily member 11B
K03173 TRAF2; TNF receptor-associated factor 2
K03175 TRAF6; TNF receptor-associated factor 6
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
K05703 FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]
K04466 MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K09253 RELB; transcription factor RelB
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K04403 MAP3K7IP1, TAB1; TAK1-binding protein 1
K04404 MAP3K7IP2, TAB2; TAK1-binding protein 2
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K04735 RELA; transcription factor p65
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K05415 IFNB; interferon beta
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04433 MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04431 MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K04379 FOS; proto-oncogene protein c-fos
K09029 FOSB; protein FosB
K09030 FOSL2; fos-like antigen 2
K04502 FOSL1; fos-like antigen 1
K04448 JUN; transcription factor AP-1
K04449 JUND; transcription factor jun-D
K09028 JUNB; transcription factor jun-B
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K08008 NOX, GP91; NADPH oxidase
K08009 CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
K08010 NCF2, P67PHOX; neutrophil cytosolic factor 2
K08011 NCF1, P47PHOX; neutrophil cytosolic factor 1
K08012 NCF4, P40PHOX; neutrophil cytosolic factor 4
K07370 BTK; Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]
K07364 TEC; tyrosine-protein kinase Tec [EC:2.7.10.2]
K14377 OSCAR; osteoclast-associated immunoglobulin-like receptor
K06512 LILR; leukocyte immunoglobulin-like receptor
K06498 FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
K06472 FCGR2A, CD32; low affinity immunoglobulin gamma Fc region receptor II-a
K12560 FCGR2B, CD32; low affinity immunoglobulin gamma Fc region receptor II-b
K16824 FCGR2C, CD32; low affinity immunoglobulin gamma Fc region receptor II-c
K06463 FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
K14378 TREM2; triggering receptor expressed on myeloid cells 2
K06551 SIRPA_B1_G; signal-regulatory protein alpha/beta1/gamma
K07992 TYROBP, DAP12; TYRO protein tyrosine kinase binding protein
K05855 SYK; spleen tyrosine kinase [EC:2.7.10.2]
K07371 BLNK; B-cell linker protein
K07361 LCP2; lymphocyte cytosolic protein 2
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K04348 PPP3C, CNA; protein phosphatase 3, catalytic subunit [EC:3.1.3.16]
K06268 PPP3R, CNB; protein phosphatase 3, regulatory subunit
K05869 CAMK4; calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]
K05870 CREB1; cyclic AMP-responsive element-binding protein 1
K09438 SPI1; transcription factor PU.1
K09455 MITF; microphthalmia-associated transcription factor
K01371 CTSK; cathepsin K [EC:3.4.22.38]
K14379 ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]
K04576 CALCR; calcitonin receptor
K06493 ITGB3; integrin beta 3
K08530 NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
K05130 IFNAR1; interferon receptor 1
K05131 IFNAR2; interferon receptor 2
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K11219 TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
K11221 STAT2; signal transducer and activator of transcription 2
K04693 IRF9, ISGF3G, P48; interferon regulatory factor 9
K04694 SOCS1, JAB; suppressor of cytokine signaling 1
K04696 SOCS3, CIS3; suppressor of cytokine signaling 3
K08091 GAB2; growth factor receptor bound protein 2-associated protein 2
K14380 FHL2; four and a half LIM domains protein 2
K08601 CYLD, USLP2; ubiquitin thioesterase CYLD [EC:3.1.2.15]
K14381 SQSTM1; sequestosome 1
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Environmental adaptation
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Human Diseases
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Cancers
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05200 Pathways in cancer [PATH:ko05200]
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K06765 DCC; deleted in colorectal carcinoma
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K08733 APPL, DIP13A; DCC-interacting protein 13 alpha
K05689 CDHE, CDH1; cadherin 1, type 1, E-cadherin
K02105 CTNNB1; catenin beta 1
K05691 CTNNA; catenin alpha
K02157 AXIN1; axin 1
K04385 AXIN2; axin 2
K02085 APC; adenomatosis polyposis coli protein
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02620 TCF7; transcription factor 7
K04490 TCF7L1; transcription factor 7-like 1
K04491 TCF7L2; transcription factor 7-like 2
K04492 LEF1; lymphoid enhancer-binding factor 1
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K04377 MYC; Myc proto-oncogene protein
K04503 CCND1; cyclin D1
K03209 WNT1; wingless-type MMTV integration site family, member 1
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00408 WNT4; wingless-type MMTV integration site family, member 4
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00445 WNT6; wingless-type MMTV integration site family, member 6
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00714 WNT8; wingless-type MMTV integration site family, member 8
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01384 WNT11; wingless-type MMTV integration site family, member 11
K01558 WNT16; wingless-type MMTV integration site family, member 16
K02432 FZD1_7, fz; frizzled 1/7
K02235 FZD2; frizzled 2
K02329 FZD3; frizzled 3
K02354 FZD4, fz4; frizzled 4
K02375 FZD5_8, fz2; frizzled 5/8
K02376 FZD6; frizzled 6
K02842 FZD9_10; frizzled 9/10
K02353 DVL; segment polarity protein dishevelled
K06237 COL4A; collagen, type IV, alpha
K05637 LAMA1_2; laminin, alpha 1/2
K06240 LAMA3_5; laminin, alpha 3/5
K06241 LAMA4; laminin, alpha 4
K05636 LAMB1; laminin, beta 1
K06243 LAMB2; laminin, beta 2
K06244 LAMB3; laminin, beta 3
K06245 LAMB4; laminin, beta 4
K05635 LAMC1; laminin, gamma 1
K06246 LAMC2; laminin, gamma 2
K06247 LAMC3; laminin, gamma 3
K05717 FN1; fibronectin 1
K06481 ITGA2; integrin alpha 2
K06476 ITGA2B; integrin alpha 2B
K06482 ITGA3; integrin alpha 3
K06485 ITGA6; integrin alpha 6
K06487 ITGAV; integrin alpha V
K05719 ITGB1; integrin beta 1
K05725 PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K09348 NKX3-1; homeobox protein Nkx-3.1
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04735 RELA; transcription factor p65
K11987 PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K13241 NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
K02161 BCL2; apoptosis regulator BCL-2
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K04570 BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
K03172 TRAF1; TNF receptor-associated factor 1
K03173 TRAF2; TNF receptor-associated factor 2
K03174 TRAF3; TNF receptor-associated factor 3
K09848 TRAF4; TNF receptor-associated factor 4
K09849 TRAF5; TNF receptor-associated factor 5
K03175 TRAF6; TNF receptor-associated factor 6
K07203 FRAP; FKBP12-rapamycin complex-associated protein
K02158 BAD; BCL2-antagonist of cell death
K07201 FOXO1; forkhead box protein O1
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
K04451 TP53, P53; tumor protein p53
K06624 CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
K06625 CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K08878 BCR1, BCR; breakpoint cluster region protein [EC:2.7.11.1]
K06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K04438 CRK, CRKII; proto-oncogene C-crk
K04707 CBL; E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
K11223 STAT5A; signal transducer and activator of transcription 5A
K11224 STAT5B; signal transducer and activator of transcription 5B
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
K11220 STAT1; signal transducer and activator of transcription 1
K05448 VEGFA; vascular endothelial growth factor A
K16858 VEGFB; vascular endothelial growth factor B
K16859 PGF; placenta growth factor
K05449 VEGFC_D; vascular endothelial growth factor C/D
K08774 TGFA; transforming growth factor, alpha
K04357 EGF; epidermal growth factor
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K05083 ERBB2, HER2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K04359 PDGFA_B; platelet derived growth factor A/B
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05459 IGF1; insulin-like growth factor 1
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K05461 KITLG; KIT ligand
K05091 KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05454 FLT3LG; fms-related tyrosine kinase 3 ligand
K05092 FLT3, FLK2; fms-related tyrosine kinase 3 [EC:2.7.10.1]
K05460 HGF; hepatocyte growth factor
K05099 MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K04358 FGF; fibroblast growth factor
K04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094 FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-binding protein 2
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS, KRAS2; GTPase KRas
K07828 NRAS; GTPase NRas
K08845 ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K04448 JUN; transcription factor AP-1
K04379 FOS; proto-oncogene protein c-fos
K01388 MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
K01398 MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
K01403 MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
K10030 IL8, CXCL8; interleukin 8
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
K09288 CCDC6, PTC; coiled-coil domain-containing protein 6
K09289 NCOA4, PTC3; nuclear receptor coactivator 4
K03176 NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K09290 TPM3; tropomyosin 3
K09291 TPR; nucleoprotein TPR
K09292 TFG; protein TFG
K09850 RASSF1; Ras association domain-containing protein 1
K08015 RASSF5, RAPL; Ras association domain-containing protein 5
K04411 STK4, MST1; serine/threonine kinase 4
K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K02677 CPKC; classical protein kinase C [EC:2.7.11.13]
K08732 RALGDS; ral guanine nucleotide dissociation stimulator
K07834 RALA; Ras-related protein Ral-A
K07835 RALB; Ras-related protein Ral-B
K08773 RALBP1; RalA-binding protein 1
K04393 CDC42; cell division control protein 42
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K04513 RHOA; Ras homolog gene family, member A
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K09293 PAX8; paired box protein 8
K08530 NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
K08524 NR2B1, RXRA; retinoid X receptor alpha
K08525 NR2B2, RXRB; retinoid X receptor beta
K08526 NR2B3, RXRG; retinoid X receptor gamma
K08528 NR1B2, RARB; retinoic acid receptor beta
K04504 NR1C2, PPARD; peroxisome proliferator-activated receptor delta
K10056 JUP; junction plakoglobin
K10055 ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
K10054 PML, TRIM19; probable transcription factor PML
K08527 NR1B1, RARA; retinoic acid receptor alpha
K08367 RUNX1, AML1; runt-related transcription factor 1
K10053 RUNX1T1, CBFA2T1; runt-related transcription factor 1; translocated to, 1
K09438 SPI1; transcription factor PU.1
K09055 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
K05066 CSF2RA, GMCSFR; granulocyte-macrophage colony-stimulating factor receptor alpha
K05061 CSF3R; granulocyte colony-stimulating factor receptor
K05090 CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K05405 IL6; interleukin 6
K06621 CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
K06620 E2F1_3; E2F transcription factor 1/3
K09389 E2F2; E2F transcription factor 2
K04453 MAX; Max protein
K16063 PIAS2; E3 SUMO-protein ligase PIAS2 [EC:6.3.2.-]
K04685 CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K02219 CKS1; cyclin-dependent kinase regulatory subunit CKS1
K03875 SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06626 CCNE; cyclin E
K06618 RB1; retinoblastoma-associated protein
K09455 MITF; microphthalmia-associated transcription factor
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04500 SMAD2_3; mothers against decapentaplegic homolog 2/3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K04462 EVI1; ecotropic virus integration site 1 protein
K04496 CTBP; C-terminal binding protein
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K08734 MLH1; DNA mismatch repair protein MLH1
K08735 MSH2; DNA mismatch repair protein MSH2
K08736 MSH3; DNA mismatch repair protein MSH3
K08737 MSH6; DNA mismatch repair protein MSH6
K02159 BAX; apoptosis regulator BAX
K08775 BRCA2, FANCD1; breast cancer 2 susceptibility protein
K04482 RAD51; DNA repair protein RAD51
K04389 TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
K02373 FADD; FAS-associated death domain protein
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04726 BID; BH3 interacting domain death agonist
K08738 CYC; cytochrome c
K03871 VHL; von Hippel-Lindau disease tumor supressor
K03872 TCEB1; transcription elongation factor B, polypeptide 1
K03873 TCEB2; transcription elongation factor B, polypeptide 2
K03868 RBX1, ROC1; RING-box protein 1
K03870 CUL2; cullin 2
K09592 EGLN, HPH; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.-]
K01679 E4.2.1.2B, fumC; fumarate hydratase, class II [EC:4.2.1.2]
K08268 HIF1A; hypoxia-inducible factor 1 alpha
K09095 HIF2A, EPAS1; hypoxia-inducible factor 2 alpha
K09097 ARNT; aryl hydrocarbon receptor nuclear translocator
K15589 ARNT2; aryl hydrocarbon receptor nuclear translocator 2
K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K07299 SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K11988 SHH; sonic hedgehog
K06225 PTCH1; patched 1
K06226 SMO; smoothened
K06227 COS2; costal 2
K06228 FU; fused [EC:2.7.11.1]
K06229 SUFU; suppressor of fused
K16797 GLI1; zinc finger protein GLI1
K16798 GLI2; zinc finger protein GLI2
K06230 GLI3; zinc finger protein GLI3
K04662 BMP2_4; bone morphogenetic protein 2/4
K06231 HHIP; hedgehog interacting protein
K11101 PTCH2; patched 2
K08557 NR3C4, AR; androgen receptor
K04079 htpG, HSP90A; molecular chaperone HtpG
K09487 HSP90B, TRA1; heat shock protein 90kDa beta
K01351 KLK3; semenogelase [EC:3.4.21.77]
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05202 Transcriptional misregulation in cancers [PATH:ko05202]
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K08367 RUNX1, AML1; runt-related transcription factor 1
K05090 CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K10789 MPO; myeloperoxidase [EC:1.11.2.2]
K05427 CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
K04736 IL3; interleukin 3
K10053 RUNX1T1, CBFA2T1; runt-related transcription factor 1; translocated to, 1
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K11644 SIN3A; paired amphipathic helix protein Sin3a
K04650 NCOR1, N-CoR; nuclear receptor co-repressor 1
K09055 CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
K09438 SPI1; transcription factor PU.1
K04391 CD14; CD14 antigen
K06461 ITGAM; integrin alpha M
K06498 FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
K10056 JUP; junction plakoglobin
K10054 PML, TRIM19; probable transcription factor PML
K08527 NR1B1, RARA; retinoic acid receptor alpha
K10051 CEBPE; CCAAT/enhancer binding protein (C/EBP), epsilon
K02162 BCL2A1; hematopoietic BCL2-related protein A1
K10055 ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
K04377 MYC; Myc proto-oncogene protein
K09063 TCF3, E2A; transcription factor E2-alpha
K09355 PBX1; pre-B-cell leukemia transcription factor 1
K01558 WNT16; wingless-type MMTV integration site family, member 16
K03211 ETV6_7, yan; ETS translocation variant 6/7
K10784 TRAV; T cell receptor alpha chain V region
K10785 TRBV; T-cell receptor beta chain V region
K01327 ELANE; leukocyte elastase [EC:3.4.21.37]
K01353 GZMB; granzyme B [EC:3.4.21.79]
K09186 MLL1; histone-lysine N-methyltransferase MLL1 [EC:2.1.1.43]
K15184 AFF1; AF4/FMR2 family member 1
K02211 CDK9; cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23]
K15188 CCNT; cyclin T
K15187 MLLT1_3, ENL, AF9; YEATS domain-containing protein 1/3
K11427 DOT1L, DOT1; histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
K15612 LMO2; rhombotin-2
K15610 PBX3; pre-B-cell leukemia transcription factor 3
K09278 RUNX2, AML3; runt-related transcription factor 2
K04676 SMAD1; mothers against decapentaplegic homolog 1
K15605 KLF3; krueppel-like factor 3
K04454 MEF2C; MADS-box transcription enhancer factor 2C
K11449 JMJD1C; jumonji domain-containing protein 1C [EC:1.14.11.-]
K09283 HMGA2; high mobility group AT-hook protein 2
K11447 UTX, UTY; histone demethylase [EC:1.14.11.-]
K11313 SUPT3H, SPT3; transcription initiation protein SPT3
K06532 PROM1; prominin 1
K05092 FLT3, FLK2; fms-related tyrosine kinase 3 [EC:2.7.10.1]
K08854 BMP2K, BIKE; BMP2 inducible kinase [EC:2.7.11.1]
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K06624 CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
K08821 CDK14, PFTK1; cyclin-dependent kinase 14 [EC:2.7.11.22]
K15613 MEIS1; homeobox protein Meis1
K15614 SIX1; homeobox protein SIX1
K15615 SIX4; homeobox protein SIX4
K15616 EYA1; eyes absent homolog 1 [EC:3.1.3.48]
K06622 CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
K00069 HPGD; 15-hydroxyprostaglandin dehydrogenase (NAD) [EC:1.1.1.141]
K05199 GRIA3; glutamate receptor 3
K00717 FUT8; glycoprotein 6-alpha-L-fucosyltransferase [EC:2.4.1.68]
K15607 TLX3, HOX11L2; T-cell leukemia homeobox protein 3
K09340 TLX1, HOX11; T-cell leukemia homeobox protein 1
K04182 CCR7; C-C chemokine receptor type 7
K15617 LDB1; LIM domain-binding protein 1
K15604 LYL1; protein lyl-1
K08024 HHEX, HEX, PRH; homeobox protein HEX
K06056 PTCRA; pre T-cell antigen receptor alpha
K09254 REL; c-Rel proto-oncogene protein
K03172 TRAF1; TNF receptor-associated factor 1
K04570 BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
K05413 CD86; CD86 antigen
K03160 TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
K15618 BCL6; B-cell lymphoma 6 protein
K06856 IGH; immunoglobulin heavy chain
K09035 CMAF, MAF; transcription factor Maf
K10151 CCND2; cyclin D2
K06590 ITGB7; integrin beta 7
K11424 WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2 [EC:2.1.1.43]
K11253 H3; histone H3
K09383 PAX5; paired box protein 5
K09293 PAX8; paired box protein 8
K08530 NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
K08524 NR2B1, RXRA; retinoid X receptor alpha
K08525 NR2B2, RXRB; retinoid X receptor beta
K08526 NR2B3, RXRG; retinoid X receptor gamma
K13105 PRCC; proline-rich protein PRCC
K09105 TFE3; transcription factor E3
K06625 CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K09633 TMPRSS2; transmembrane protease, serine 2
K09435 ERG; transcriptional regulator ERG
K01348 PLAU; urokinase plasminogen activator [EC:3.4.21.73]
K01343 PLAT; tissue plasminogen activator [EC:3.4.21.68]
K01394 MMP3; matrix metalloproteinase-3 (stromelysin 1, progelatinase) [EC:3.4.24.17]
K01403 MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
K15619 SPINT1; Kunitz-type protease inhibitor 1
K04387 IL1R2; interleukin 1 receptor type II
K09431 ETV1; ets translocation variant 1
K15592 ETV4; ets translocation variant 4
K15593 ETV5; ets translocation variant 5
K15379 SLC45A3; solute carrier family 45, member 3
K04376 ELK4, SAP1; ETS domain-containing protein Elk-4
K12823 DDX5, DBP2; ATP-dependent RNA helicase DDX5/DBP2 [EC:3.6.4.13]
K09109 NMYC, MYCN; N-myc proto-oncogene protein
K04453 MAX; Max protein
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
K05725 PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
K04451 TP53, P53; tumor protein p53
K11459 PCGF4, BMI1; polycomb group RING finger protein 4
K04684 SP1; transcription factor Sp1
K10500 ZBTB17, MIZ1; zinc finger and BTB domain-containing protein 17
K03176 NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K02583 NGFR; nerve growth factor receptor (TNFR superfamily member 16)
K14970 MEN1, MNN1; menin
K13209 EWSR1; RNA-binding protein EWS
K09436 FLI1; friend leukemia integration 1 transcription factor
K05459 IGF1; insulin-like growth factor 1
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K10138 IGFBP3; insulin-like growth factor-binding protein 3
K09437 FEV; ETS oncogene family protein FEV
K09053 ATF1; activating transcription factor 1
K15589 ARNT2; aryl hydrocarbon receptor nuclear translocator 2
K04728 ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
K15620 GOLPH3, GPP34; golgi phosphoprotein 3
K09234 WT1; Wilms tumor protein 1
K04359 PDGFA_B; platelet derived growth factor A/B
K05069 IL2RB; interleukin 2 receptor beta
K15621 BAIAP3; BAI1-associated protein 3
K06571 TM4SF2, MXS1; transmembrane 4 superfamily member 2
K15622 MLF1; myeloid leukemia factor 1
K08559 NR4A3, NOR1; nuclear receptor subfamily 4 group A member 3
K14651 TAF15; transcription initiation factor TFIID subunit 15
K13098 TLS, FUS; RNA-binding protein FUS
K04452 DDIT3, GADD153; DNA damage-inducible transcript 3
K10048 CEBPB; CCAAT/enhancer binding protein (C/EBP), beta
K05405 IL6; interleukin 6
K14242 NFKBIZ; NF-kappa-B inhibitor zeta
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K10030 IL8, CXCL8; interleukin 8
K07201 FOXO1; forkhead box protein O1
K05096 FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
K15623 SS18, SSXT, SYT; protein SSXT
K15624 SSX1; protein SSX1
K15625 SSX2; protein SSX2
K15626 NUPR1, COM1; nuclear protein, 1
K15627 ASPSCR1, ASPL; tether containing UBX domain for GLUT4
K05099 MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
|
05205 Proteoglycans in cancer [PATH:ko05205]
|
05204 Chemical carcinogenesis [PATH:ko05204]
|
05203 Viral carcinogenesis [PATH:ko05203]
|
05210 Colorectal cancer [PATH:ko05210]
|
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02157 AXIN1; axin 1
K04385 AXIN2; axin 2
K02105 CTNNB1; catenin beta 1
K02085 APC; adenomatosis polyposis coli protein
K02620 TCF7; transcription factor 7
K04490 TCF7L1; transcription factor 7-like 1
K04491 TCF7L2; transcription factor 7-like 2
K04492 LEF1; lymphoid enhancer-binding factor 1
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K04377 MYC; Myc proto-oncogene protein
K04503 CCND1; cyclin D1
K07827 KRAS, KRAS2; GTPase KRas
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K02158 BAD; BCL2-antagonist of cell death
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K08845 ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K04448 JUN; transcription factor AP-1
K04379 FOS; proto-oncogene protein c-fos
K08732 RALGDS; ral guanine nucleotide dissociation stimulator
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K04513 RHOA; Ras homolog gene family, member A
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K06765 DCC; deleted in colorectal carcinoma
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K08733 APPL, DIP13A; DCC-interacting protein 13 alpha
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04500 SMAD2_3; mothers against decapentaplegic homolog 2/3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K08734 MLH1; DNA mismatch repair protein MLH1
K08735 MSH2; DNA mismatch repair protein MSH2
K08736 MSH3; DNA mismatch repair protein MSH3
K08737 MSH6; DNA mismatch repair protein MSH6
K02159 BAX; apoptosis regulator BAX
K02161 BCL2; apoptosis regulator BCL-2
K08738 CYC; cytochrome c
K04451 TP53, P53; tumor protein p53
|
05212 Pancreatic cancer [PATH:ko05212]
|
K07827 KRAS, KRAS2; GTPase KRas
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K05729 ARHGEF6, PIXA; Rho guanine nucleotide exchange factor 6
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K02158 BAD; BCL2-antagonist of cell death
K04570 BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K08845 ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K08732 RALGDS; ral guanine nucleotide dissociation stimulator
K07834 RALA; Ras-related protein Ral-A
K07835 RALB; Ras-related protein Ral-B
K08773 RALBP1; RalA-binding protein 1
K04393 CDC42; cell division control protein 42
K08774 TGFA; transforming growth factor, alpha
K04357 EGF; epidermal growth factor
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K05083 ERBB2, HER2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K04692 STAT3; signal transducer and activator of transcription 3
K11220 STAT1; signal transducer and activator of transcription 1
K05448 VEGFA; vascular endothelial growth factor A
K06621 CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K04503 CCND1; cyclin D1
K06618 RB1; retinoblastoma-associated protein
K06620 E2F1_3; E2F transcription factor 1/3
K09389 E2F2; E2F transcription factor 2
K04451 TP53, P53; tumor protein p53
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04500 SMAD2_3; mothers against decapentaplegic homolog 2/3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K08775 BRCA2, FANCD1; breast cancer 2 susceptibility protein
K04482 RAD51; DNA repair protein RAD51
|
05214 Glioma [PATH:ko05214]
|
05216 Thyroid cancer [PATH:ko05216]
|
05221 Acute myeloid leukemia [PATH:ko05221]
|
05220 Chronic myeloid leukemia [PATH:ko05220]
|
K08878 BCR1, BCR; breakpoint cluster region protein [EC:2.7.11.1]
K06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K04438 CRK, CRKII; proto-oncogene C-crk
K04707 CBL; E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K02158 BAD; BCL2-antagonist of cell death
K04570 BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
K04451 TP53, P53; tumor protein p53
K06624 CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
K04364 GRB2; growth factor receptor-binding protein 2
K08091 GAB2; growth factor receptor bound protein 2-associated protein 2
K07293 PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS, KRAS2; GTPase KRas
K07828 NRAS; GTPase NRas
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K08845 ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K06279 SHC; src homology 2 domain-containing transforming protein C
K04377 MYC; Myc proto-oncogene protein
K11223 STAT5A; signal transducer and activator of transcription 5A
K11224 STAT5B; signal transducer and activator of transcription 5B
K06621 CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
K06625 CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K04503 CCND1; cyclin D1
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K06618 RB1; retinoblastoma-associated protein
K06620 E2F1_3; E2F transcription factor 1/3
K09389 E2F2; E2F transcription factor 2
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04501 SMAD4; mothers against decapentaplegic homolog 4
K04462 EVI1; ecotropic virus integration site 1 protein
K08367 RUNX1, AML1; runt-related transcription factor 1
K04496 CTBP; C-terminal binding protein
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
|
05217 Basal cell carcinoma [PATH:ko05217]
|
05218 Melanoma [PATH:ko05218]
|
05211 Renal cell carcinoma [PATH:ko05211]
|
05219 Bladder cancer [PATH:ko05219]
|
05215 Prostate cancer [PATH:ko05215]
|
05213 Endometrial cancer [PATH:ko05213]
|
05222 Small cell lung cancer [PATH:ko05222]
|
05223 Non-small cell lung cancer [PATH:ko05223]
|
|
Immune diseases
|
|
Neurodegenerative diseases
|
|
Substance dependence
|
|
Cardiovascular diseases
|
|
Endocrine and metabolic diseases
|
|
Infectious diseases
|
05110 Vibrio cholerae infection [PATH:ko05110]
|
05111 Vibrio cholerae pathogenic cycle [PATH:ko05111]
|
05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
|
05130 Pathogenic Escherichia coli infection [PATH:ko05130]
|
05132 Salmonella infection [PATH:ko05132]
|
05131 Shigellosis [PATH:ko05131]
|
05133 Pertussis [PATH:ko05133]
|
05134 Legionellosis [PATH:ko05134]
|
05150 Staphylococcus aureus infection [PATH:ko05150]
|
05152 Tuberculosis [PATH:ko05152]
|
05100 Bacterial invasion of epithelial cells [PATH:ko05100]
|
05166 HTLV-I infection [PATH:ko05166]
|
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K07299 SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K06724 NRP1; neuropilin 1
K06527 VCAM1; vascular cell adhesion molecule 1
K06450 CD3D; T-cell surface glycoprotein CD3 delta chain
K06451 CD3E; T-cell surface glycoprotein CD3 epsilon chain
K06452 CD3G; T-cell surface glycoprotein CD3 gamma chain
K06490 ICAM1; intercellular adhesion molecule 1
K05718 ITGAL; integrin alpha L
K06464 ITGB2; integrin beta 2
K06271 TLN; talin
K04377 MYC; Myc proto-oncogene protein
K08874 TRRAP; transformation/transcription domain-associated protein
K11304 TIP60, KAT5, ESA1; histone acetyltransferase HTATIP [EC:2.3.1.48]
K10151 CCND2; cyclin D2
K15304 RANBP3; Ran-binding protein 3
K07936 RAN; GTP-binding nuclear protein Ran
K14290 XPO1, CRM1; exportin-1
K06751 MHC1; major histocompatibility complex, class I
K08057 CALR; calreticulin
K04348 PPP3C, CNA; protein phosphatase 3, catalytic subunit [EC:3.1.3.16]
K06268 PPP3R, CNB; protein phosphatase 3, regulatory subunit
K04446 NFATC, NFAT; nuclear factor of activated T-cells, cytoplasmic
K08054 CANX; calnexin
K05069 IL2RB; interleukin 2 receptor beta
K05070 IL2RG; interleukin 2 receptor gamma
K11217 JAK1; Janus kinase 1 [EC:2.7.10.2]
K11218 JAK3; Janus kinase 3 [EC:2.7.10.2]
K11223 STAT5A; signal transducer and activator of transcription 5A
K11224 STAT5B; signal transducer and activator of transcription 5B
K00787 FDPS; farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]
K02833 HRAS; GTPase HRas
K07827 KRAS, KRAS2; GTPase KRas
K07828 NRAS; GTPase NRas
K07829 RRAS; Ras-related protein R-Ras
K07830 RRAS2, TC21; Ras-related protein R-Ras2
K07831 MRAS; Ras-related protein M-Ras
K05862 VDAC1; voltage-dependent anion channel protein 1
K05863 SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31
K15040 VDAC2; voltage-dependent anion channel protein 2
K15041 VDAC3; voltage-dependent anion channel protein 3
K05770 BZRP; benzodiazapine receptor
K15305 VAC14, TAX1BP2; vacuole morphology and inheritance protein 14
K15306 RANBP1; Ran-binding protein 1
K06679 MAD1; mitotic spindle assembly checkpoint protein MAD1
K02537 MAD2; mitotic spindle assembly checkpoint protein MAD2
K06637 BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [EC:2.7.11.1]
K02180 BUB3; cell cycle arrest protein BUB3
K03363 CDC20; cell division cycle 20, cofactor of APC complex
K03348 APC1; anaphase-promoting complex subunit 1
K03349 APC2; anaphase-promoting complex subunit 2
K03350 APC3, CDC27; anaphase-promoting complex subunit 3
K03351 APC4; anaphase-promoting complex subunit 4
K03352 APC5; anaphase-promoting complex subunit 5
K03353 APC6, CDC16; anaphase-promoting complex subunit 6
K03354 APC7; anaphase-promoting complex subunit 7
K03355 APC8, CDC23; anaphase-promoting complex subunit 8
K03356 APC9; anaphase-promoting complex subunit 9
K03357 APC10, DOC1; anaphase-promoting complex subunit 10
K03358 APC11; anaphase-promoting complex subunit 11
K03359 APC12, CDC26; anaphase-promoting complex subunit 12
K12416 SWM1, APC13; anaphase-promoting complex subunit SWM1
K06635 PTTG; securin
K06625 CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K04802 PCNA; proliferating cell nuclear antigen
K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
K02328 POLD2; DNA polymerase delta subunit 2
K03504 POLD3; DNA polymerase delta subunit 3
K03505 POLD4; DNA polymerase delta subunit 4
K02324 POLE1; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
K04503 CCND1; cyclin D1
K10152 CCND3; cyclin D3
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K06618 RB1; retinoblastoma-associated protein
K06620 E2F1_3; E2F transcription factor 1/3
K09389 E2F2; E2F transcription factor 2
K06621 CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
K04685 CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
K03209 WNT1; wingless-type MMTV integration site family, member 1
K00182 WNT2; wingless-type MMTV integration site family, member 2
K00312 WNT3; wingless-type MMTV integration site family, member 3
K00408 WNT4; wingless-type MMTV integration site family, member 4
K00444 WNT5; wingless-type MMTV integration site family, member 5
K00445 WNT6; wingless-type MMTV integration site family, member 6
K00572 WNT7; wingless-type MMTV integration site family, member 7
K00714 WNT8; wingless-type MMTV integration site family, member 8
K01064 WNT9; wingless-type MMTV integration site family, member 9
K01357 WNT10; wingless-type MMTV integration site family, member 10
K01384 WNT11; wingless-type MMTV integration site family, member 11
K01558 WNT16; wingless-type MMTV integration site family, member 16
K02432 FZD1_7, fz; frizzled 1/7
K02235 FZD2; frizzled 2
K02329 FZD3; frizzled 3
K02354 FZD4, fz4; frizzled 4
K02375 FZD5_8, fz2; frizzled 5/8
K02376 FZD6; frizzled 6
K02842 FZD9_10; frizzled 9/10
K04690 FZDN, fz3; frizzled
K02353 DVL; segment polarity protein dishevelled
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K02105 CTNNB1; catenin beta 1
K02085 APC; adenomatosis polyposis coli protein
K12076 DLG1; disks large protein 1
K04359 PDGFA_B; platelet derived growth factor A/B
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K03156 TNFA; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
K04416 MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
K04430 MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K04448 JUN; transcription factor AP-1
K15307 GPS2; G protein pathway suppressor 2
K04386 IL1R1; interleukin 1 receptor type I
K04387 IL1R2; interleukin 1 receptor type II
K10784 TRAV; T cell receptor alpha chain V region
K10785 TRBV; T-cell receptor beta chain V region
K04421 MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K03159 TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3
K03160 TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
K05151 TNFRSF13C, BAFFR; tumor necrosis factor receptor superfamily member 13C
K04466 MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
K09253 RELB; transcription factor RelB
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K05429 IL2; interleukin 2
K05068 IL2RA, CD25; interleukin 2 receptor alpha
K05433 IL15; interleukin 15
K05074 IL15RA; interleukin 15 receptor alpha
K05405 IL6; interleukin 6
K05427 CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
K05468 LTA, TNFB; lymphotoxin alpha (TNF superfamily, member 1)
K04570 BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
K04725 XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
K15308 TTP; tristetraprolin
K08065 NFYB; nuclear transcription Y subunit beta
K06752 MHC2; major histocompatibility complex, class II
K04378 SRF; serum response factor
K04376 ELK4, SAP1; ETS domain-containing protein Elk-4
K04375 ELK1; ETS domain-containing protein Elk-1
K09438 SPI1; transcription factor PU.1
K02678 ETS, pnt; c-ets proto-oncogene protein
K03120 TBP, tbp; transcription initiation factor TFIID TATA-box-binding protein
K04379 FOS; proto-oncogene protein c-fos
K09203 EGR1; early growth response protein 1
K12496 EGR2; early growth response protein 2
K04502 FOSL1; fos-like antigen 1
K08041 ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042 ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08043 ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
K08044 ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045 ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046 ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047 ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048 ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049 ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K05870 CREB1; cyclic AMP-responsive element-binding protein 1
K09052 CREM; cAMP response element modulator
K09053 ATF1; activating transcription factor 1
K04450 ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
K09032 ATF3, LRF1; activating transcription factor 3
K04374 ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
K09027 XBP1; X box-binding protein 1
K15309 CRTC1, TORC1; CREB-regulated transcription coactivator 1
K16333 CRTC2, TORC2; CREB-regulated transcription coactivator 2
K16334 CRTC3, TORC3; CREB-regulated transcription coactivator 3
K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K06062 PCAF, KAT2, GCN5; histone acetyltransferase [EC:2.3.1.48]
K09063 TCF3, E2A; transcription factor E2-alpha
K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
K06622 CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
K11126 TERT, EST2; telomerase reverse transcriptase [EC:2.7.7.49]
K09420 MYB; myb proto-oncogene protein
K09421 MYBL; myb-related protein
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04500 SMAD2_3; mothers against decapentaplegic homolog 2/3
K04501 SMAD4; mothers against decapentaplegic homolog 4
K04728 ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
K02216 CHK1; serine/threonine-protein kinase Chk1 [EC:2.7.11.1]
K06641 CHK2; serine/threonine-protein kinase Chk2 [EC:2.7.11.1]
K04451 TP53, P53; tumor protein p53
K02159 BAX; apoptosis regulator BAX
K15310 TP53INP1; tumor protein p53-inducible nuclear protein 1
K09341 MSX; homeobox protein MSX
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05162 Measles [PATH:ko05162]
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05164 Influenza A [PATH:ko05164]
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05161 Hepatitis B [PATH:ko05161]
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05160 Hepatitis C [PATH:ko05160]
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05168 Herpes simplex infection [PATH:ko05168]
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05169 Epstein-Barr virus infection [PATH:ko05169]
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05146 Amoebiasis [PATH:ko05146]
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05144 Malaria [PATH:ko05144]
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05145 Toxoplasmosis [PATH:ko05145]
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05140 Leishmaniasis [PATH:ko05140]
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05142 Chagas disease (American trypanosomiasis) [PATH:ko05142]
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K10160 TLR4; toll-like receptor 4
K05842 TRIF; toll-like receptor adapter molecule 1
K13729 TCAC2, TC52; thiol-dependent reductase 1
K10159 TLR2; toll-like receptor 2
K10169 TLR6; toll-like receptor 6
K10161 TLR9; toll-like receptor 9
K04729 MYD88; myeloid differentiation primary response protein MyD88
K04730 IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
K04733 IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
K03175 TRAF6; TNF receptor-associated factor 6
K04430 MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04379 FOS; proto-oncogene protein c-fos
K04448 JUN; transcription factor AP-1
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K05415 IFNB; interferon beta
K12499 CCL5; C-C motif chemokine 5
K14624 CCL2, MCP1; C-C motif chemokine 2
K03156 TNFA; tumor necrosis factor superfamily, member 2
K05406 IL12A; interleukin 12A
K05425 IL12B; interleukin 12B
K05405 IL6; interleukin 6
K10030 IL8, CXCL8; interleukin 8
K05408 CCL3; C-C motif chemokine 3
K04519 IL1B; interleukin 1 beta
K03456 PPP2R1; protein phosphatase 2 (formerly 2A), regulatory subunit A
K04354 PPP2R2; protein phosphatase 2 (formerly 2A), regulatory subunit B
K04382 PPP2C; protein phosphatase 2 (formerly 2A), catalytic subunit [EC:3.1.3.16]
K04687 IFNG; interferon gamma
K05132 IFNGR1, CD119; interferon gamma receptor 1
K05133 IFNGR2; interferon gamma receptor 2
K03158 TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
K13241 NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
K03990 C3; complement component 3
K08057 CALR; calreticulin
K03986 C1QA; complement C1q subcomponent subunit A
K03987 C1QB; complement C1q subcomponent subunit B
K03988 C1QG; complement C1q subcomponent subunit C
K08571 E3.4.22.51; cruzipain [EC:3.4.22.51]
K05443 IL10, CSIF; interleukin 10
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K01283 E3.4.15.1, ACE; peptidyl-dipeptidase A [EC:3.4.15.1]
K03916 BDKRB2; bradykinin receptor B2
K04634 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
K04635 GNA11; guanine nucleotide-binding protein subunit alpha-11
K04636 GNA14; guanine nucleotide-binding protein subunit alpha-14
K04637 GNA15; guanine nucleotide-binding protein subunit alpha-15
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K01354 ptrB; oligopeptidase B [EC:3.4.21.83]
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04534 GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
K04632 GNAS; guanine nucleotide-binding protein G(s) subunit alpha
K04633 GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
K08041 ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04500 SMAD2_3; mothers against decapentaplegic homolog 2/3
K03982 SERPINE1, PAI1; plasminogen activator inhibitor-1
K04389 TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
K02373 FADD; FAS-associated death domain protein
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04724 CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
K10784 TRAV; T cell receptor alpha chain V region
K10785 TRBV; T-cell receptor beta chain V region
K06450 CD3D; T-cell surface glycoprotein CD3 delta chain
K06451 CD3E; T-cell surface glycoprotein CD3 epsilon chain
K06452 CD3G; T-cell surface glycoprotein CD3 gamma chain
K06453 CD3Z; CD3Z antigen, zeta polypeptide
K05429 IL2; interleukin 2
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05143 African trypanosomiasis [PATH:ko05143]
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