 Metabolism
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Genetic Information Processing
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 Environmental Information Processing
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Membrane transport
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Signal transduction
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02020 Two-component system [PATH:ko02020]
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 02022 Two-component system [BR:ko02022]
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04010 MAPK signaling pathway [PATH:ko04010]
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K04344 CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
K04849 CACNA1B; voltage-dependent calcium channel N type alpha-1B
K04850 CACNA1C; voltage-dependent calcium channel L type alpha-1C
K04851 CACNA1D; voltage-dependent calcium channel L type alpha-1D
K04852 CACNA1E; voltage-dependent calcium channel R type alpha-1E
K04853 CACNA1F; voltage-dependent calcium channel L type alpha-1F
K04854 CACNA1G; voltage-dependent calcium channel T type alpha-1G
K04855 CACNA1H; voltage-dependent calcium channel T type alpha-1H
K04856 CACNA1I; voltage-dependent calcium channel T type alpha-1I
K04857 CACNA1S; voltage-dependent calcium channel L type alpha-1S
K05315 CACNA1N; voltage-dependent calcium channel alpha 1, invertebrate
K04858 CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
K04859 CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
K04860 CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
K04861 CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
K05316 CACNA2DN; voltage-dependent calcium channel alpha-2/delta, invertebrate
K04862 CACNB1; voltage-dependent calcium channel beta-1
K04863 CACNB2; voltage-dependent calcium channel beta-2
K04864 CACNB3; voltage-dependent calcium channel beta-3
K04865 CACNB4; voltage-dependent calcium channel beta-4
K05317 CACNBN; voltage-dependent calcium channel beta, invertebrate
K04866 CACNG1; voltage-dependent calcium channel gamma-1
K04867 CACNG2; voltage-dependent calcium channel gamma-2
K04868 CACNG3; voltage-dependent calcium channel gamma-3
K04869 CACNG4; voltage-dependent calcium channel gamma-4
K04870 CACNG5; voltage-dependent calcium channel gamma-5
K04871 CACNG6; voltage-dependent calcium channel gamma-6
K04872 CACNG7; voltage-dependent calcium channel gamma-7
K04873 CACNG8; voltage-dependent calcium channel gamma-8
K04345 PKA; protein kinase A [EC:2.7.11.11]
K02677 CPKC; classical protein kinase C [EC:2.7.11.13]
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
K04347 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K04348 PPP3C, CNA; protein phosphatase 3, catalytic subunit [EC:3.1.3.16]
K06268 PPP3R, CNB; protein phosphatase 3, regulatory subunit
K04349 RASGRF1; Ras-specific guanine nucleotide-releasing factor 1
K12326 RASGRF2; Ras-specific guanine nucleotide-releasing factor 2
K04350 RASGRP1; RAS guanyl-releasing protein 1
K12361 RASGRP2; RAS guanyl-releasing protein 2
K12362 RASGRP3; RAS guanyl-releasing protein 3
K12363 RASGRP4; RAS guanyl-releasing protein 4
K08018 RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor (GEF) 2
K08052 NF1; neurofibromin 1
K04352 RASA1, RASGAP; Ras GTPase-activating protein 1
K08053 RASA2, GAP1M; Ras GTPase-activating protein 2
K04353 RAP1A; Ras-related protein Rap-1A
K07836 RAP1B; Ras-related protein Rap-1B
K02582 NGFB; nerve growth factor, beta
K04355 BDNF; brain-derived neurotrophic factor
K04356 NTF3; neurotrophin 3
K12457 NTF4; neurotrophin 4
K04357 EGF; epidermal growth factor
K04358 FGF; fibroblast growth factor
K04359 PDGFA_B; platelet derived growth factor A/B
K03176 NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K04360 NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
K05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094 FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
K05095 FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-binding protein 2
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS, KRAS2; GTPase KRas
K07828 NRAS; GTPase NRas
K07829 RRAS; Ras-related protein R-Ras
K07830 RRAS2, TC21; Ras-related protein R-Ras2
K07831 MRAS; Ras-related protein M-Ras
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04367 MOS; proto-oncogene serine/threonine-protein kinase mos [EC:2.7.11.1]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04370 MP1, MAP2K1IP1; mitogen-activated protein kinase kinase 1 interacting protein 1
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K04372 MKNK, MNK; MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]
K04373 RPS6KA, RSK2; p90 ribosomal S6 kinase [EC:2.7.11.1]
K04374 ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
K04375 ELK1; ETS domain-containing protein Elk-1
K04376 ELK4, SAP1; ETS domain-containing protein Elk-4
K04377 MYC; Myc proto-oncogene protein
K04378 SRF; serum response factor
K04379 FOS; proto-oncogene protein c-fos
K04380 MAPT, TAU; microtubule-associated protein tau
K04381 STMN1; stathmin
K16342 PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]
K03156 TNFA; tumor necrosis factor superfamily, member 2
K04383 IL1A; interleukin 1 alpha
K04519 IL1B; interleukin 1 beta
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K03158 TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
K04386 IL1R1; interleukin 1 receptor type I
K04387 IL1R2; interleukin 1 receptor type II
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04389 TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
K04391 CD14; CD14 antigen
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K07860 RAC2; Ras-related C3 botulinum toxin substrate 2
K07861 RAC3; Ras-related C3 botulinum toxin substrate 3
K04393 CDC42; cell division control protein 42
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K03173 TRAF2; TNF receptor-associated factor 2
K02308 DAXX; death-associated protein 6
K03175 TRAF6; TNF receptor-associated factor 6
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04403 MAP3K7IP1, TAB1; TAK1-binding protein 1
K04404 MAP3K7IP2, TAB2; TAK1-binding protein 2
K04405 SITPEC, ECSIT; evolutionarily conserved signaling intermediate in Toll pathways
K04406 MAP4K3, GLK; mitogen-activated protein kinase kinase kinase kinase 3 [EC:2.7.11.1]
K04407 MAP4K4, HGK; mitogen-activated protein kinase kinase kinase kinase 4 [EC:2.7.11.1]
K04408 MAP4K1, HPK1; mitogen-activated protein kinase kinase kinase kinase 1 [EC:2.7.11.1]
K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
K04410 PAK2; p21-activated kinase 2 [EC:2.7.11.1]
K04411 STK4, MST1; serine/threonine kinase 4
K04412 STK3, MST2; serine/threonine kinase 3
K04414 MAP4K2, GCK; mitogen-activated protein kinase kinase kinase kinase 2 [EC:2.7.11.1]
K04415 MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8 [EC:2.7.11.25]
K04416 MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
K04419 MAP3K11, MLK3; mitogen-activated protein kinase kinase kinase 11 [EC:2.7.11.25]
K04420 MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2 [EC:2.7.11.25]
K04421 MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]
K04422 MAP3K13, LZK; mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25]
K04423 MAP3K12, MUK; mitogen-activated protein kinase kinase kinase 12 [EC:2.7.11.25]
K04424 ZAK, MLTK; sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25]
K04425 MAP3K6, ASK2; mitogen-activated protein kinase kinase kinase 6 [EC:2.7.11.25]
K04426 MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K04428 MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25]
K04429 TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]
K04430 MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
K04431 MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04432 MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
K04433 MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
K04434 MAPK8IP1, JIP1; mitogen-activated protein kinase 8 interacting protein 1
K04435 MAPK8IP2, JIP2; mitogen-activated protein kinase 8 interacting protein 2
K04436 MAPK8IP3, JIP3; mitogen-activated protein kinase 8 interacting protein 3
K04437 FLNA; filamin
K04438 CRK, CRKII; proto-oncogene C-crk
K04439 ARRB; beta-arrestin
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04442 MAPKAPK5, PRAK; mitogen-activated protein kinase-activated protein kinase 5 [EC:2.7.11.1]
K04443 MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
K04444 MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]
K04445 MSK1, RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
K16510 MSK2, RPS6KA4; ribosomal protein S6 kinase alpha-4 [EC:2.7.11.1]
K05866 CDC25B; cell division cycle 25B [EC:3.1.3.48]
K04448 JUN; transcription factor AP-1
K04449 JUND; transcription factor jun-D
K04450 ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
K04451 TP53, P53; tumor protein p53
K04452 DDIT3, GADD153; DNA damage-inducible transcript 3
K04453 MAX; Max protein
K04454 MEF2C; MADS-box transcription enhancer factor 2C
K04455 HSPB1; heat shock protein beta-1
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04457 PPM1A, PP2CA; protein phosphatase 1A (formerly 2C) [EC:3.1.3.16]
K04458 PTP; protein-tyrosine phosphatase [EC:3.1.3.48]
K04459 DUSP, MKP; dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]
K04460 PPP5C, PP5; protein phosphatase 5 [EC:3.1.3.16]
K04461 PPM1B, PP2CB; protein phosphatase 1B (formerly 2C) [EC:3.1.3.16]
K03283 HSPA1_8; heat shock 70kDa protein 1/8
K04462 EVI1; ecotropic virus integration site 1 protein
K04463 MAP2K5, MEK5; mitogen-activated protein kinase kinase 5 [EC:2.7.12.2]
K04464 MAPK7, ERK5; mitogen-activated protein kinase 7 [EC:2.7.11.24]
K04465 NR4A1, HMR; nuclear receptor subfamily 4 group A member 1
K04466 MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04468 NLK; nemo like kinase [EC:2.7.11.24]
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04735 RELA; transcription factor p65
K09253 RELB; transcription factor RelB
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04013 MAPK signaling pathway - fly [PATH:ko04013]
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04011 MAPK signaling pathway - yeast [PATH:ko04011]
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K11234 MFAL; mating pheromone alpha-factor
K11235 MFA; mating pheromone A-factor
K11213 STE2; pheromone alpha factor receptor
K04627 STE3; pheromone a factor receptor
K07972 GNB; guanine nucleotide-binding protein subunit beta, other
K07973 GNG; guanine nucleotide-binding protein subunit gamma, other
K04393 CDC42; cell division control protein 42
K11236 CDC24; cell division control protein 24
K11237 BEM1; bud emergence protein 1
K11238 BNI1; cytokinesis protein
K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
K11228 STE11; mitogen-activated protein kinase kinase kinase [EC:2.7.11.1]
K11239 STE5; pheromone-response scaffold protein
K11226 STE7; mitogen-activated protein kinase kinase [EC:2.7.12.2]
K11240 MSG5; tyrosine-protein phosphatase [EC:3.1.3.48]
K11241 DIG1; down-regulator of invasive growth 1
K11242 DIG2; down-regulator of invasive growth 2
K11215 STE12; transcription factor STE12
K12412 MCM1; pheromone receptor transcription factor
K11243 FUS1; nuclear fusion protein
K06652 FAR1; cyclin-dependent kinase inhibitor FAR1
K11244 WSC; cell wall integrity and stress response component
K11245 MID2; mating pheromone-induced death protein 2
K04513 RHOA, RHO1; Ras homolog gene family, member A
K02677 CPKC; classical protein kinase C [EC:2.7.11.13]
K11229 BCK1; mitogen-activated protein kinase kinase kinase [EC:2.7.11.1]
K08294 MKK1_2; mitogen-activated protein kinase kinase [EC:2.7.12.2]
K04464 MAPK7, ERK5; mitogen-activated protein kinase 7 [EC:2.7.11.24]
K09291 TPR; nucleoprotein TPR
K06649 SWI4; regulatory protein SWI4
K06648 SWI6; regulatory protein SWI6
K11246 SHO1; SHO1 osmosensor
K11231 SLN1; osomolarity two-component system, sensor histidine kinase SLN1 [EC:2.7.13.3]
K11232 YPD1; osomolarity two-component system, phosphorelay intermediate protein YPD1
K11233 SSK1; osomolarity two-component system, response regulator SSK1
K11230 SSK2; mitogen-activated protein kinase kinase kinase [EC:2.7.11.25]
K11227 PBS2; mitogen-activated protein kinase kinase [EC:2.7.12.2]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K09468 MSN2_4; zinc finger protein MSN2/4
K01759 E4.4.1.5, GLO1, gloA; lactoylglutathione lyase [EC:4.4.1.5]
K09448 TEAD; transcriptional enhancer factor
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04012 ErbB signaling pathway [PATH:ko04012]
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04310 Wnt signaling pathway [PATH:ko04310]
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04330 Notch signaling pathway [PATH:ko04330]
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04340 Hedgehog signaling pathway [PATH:ko04340]
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04350 TGF-beta signaling pathway [PATH:ko04350]
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04390 Hippo signaling pathway [PATH:ko04390]
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04391 Hippo signaling pathway -fly [PATH:ko04391]
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04370 VEGF signaling pathway [PATH:ko04370]
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04630 Jak-STAT signaling pathway [PATH:ko04630]
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04064 NF-kappa B signaling pathway [PATH:ko04064]
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04668 TNF signaling pathway [PATH:ko04668]
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04066 HIF-1 signaling pathway [PATH:ko04066]
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04020 Calcium signaling pathway [PATH:ko04020]
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04070 Phosphatidylinositol signaling system [PATH:ko04070]
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04151 PI3K-Akt signaling pathway [PATH:ko04151]
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04150 mTOR signaling pathway [PATH:ko04150]
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04075 Plant hormone signal transduction [PATH:ko04075]
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Signaling molecules and interaction
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Cellular Processes
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Transport and catabolism
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Cell motility
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Cell growth and death
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Cell communication
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04510 Focal adhesion [PATH:ko04510]
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04520 Adherens junction [PATH:ko04520]
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04530 Tight junction [PATH:ko04530]
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04540 Gap junction [PATH:ko04540]
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K07372 GJA1, CX43; gap junction protein, alpha 1
K07373 GJD2; gap junction delta-2 protein
K04289 LPAR1, EDG2; lysophosphatidic acid receptor 1
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04359 PDGFA_B; platelet derived growth factor A/B
K05450 PDGFC_D; platelet derived growth factor C/D
K04357 EGF; epidermal growth factor
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-binding protein 2
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS, KRAS2; GTPase KRas
K07828 NRAS; GTPase NRas
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
K04420 MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2 [EC:2.7.11.25]
K04463 MAP2K5, MEK5; mitogen-activated protein kinase kinase 5 [EC:2.7.12.2]
K04464 MAPK7, ERK5; mitogen-activated protein kinase 7 [EC:2.7.11.24]
K07374 TUBA; tubulin alpha
K07375 TUBB; tubulin beta
K08959 CSNK1D; casein kinase 1, delta [EC:2.7.11.1]
K02087 CDK1, CDC2; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K05701 TJP1, ZO1; tight junction protein 1
K04141 ADRB1; adrenergic receptor beta-1
K04144 DRD1; dopamine receptor D1
K04632 GNAS; guanine nucleotide-binding protein G(s) subunit alpha
K04145 DRD2; dopamine receptor D2
K08041 ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042 ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08043 ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
K08044 ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045 ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046 ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047 ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048 ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049 ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04157 HTR2; 5-hydroxytryptamine receptor 2
K04603 GRM1; metabotropic glutamate receptor 1
K04604 GRM5; metabotropic glutamate receptor 5
K04635 GNA11; guanine nucleotide-binding protein subunit alpha-11
K04634 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K04958 ITPR1; inositol 1,4,5-triphosphate receptor type 1
K04959 ITPR2; inositol 1,4,5-triphosphate receptor type 2
K04960 ITPR3; inositol 1,4,5-triphosphate receptor type 3
K02677 CPKC; classical protein kinase C [EC:2.7.11.13]
K12318 GUCY1A; guanylate cyclase soluble subunit alpha [EC:4.6.1.2]
K12319 GUCY1B; guanylate cyclase soluble subunit beta [EC:4.6.1.2]
K07376 PRKG; protein kinase, cGMP-dependent [EC:2.7.11.12]
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Organismal Systems
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Immune system
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Endocrine system
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04911 Insulin secretion [PATH:ko04911]
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04910 Insulin signaling pathway [PATH:ko04910]
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04920 Adipocytokine signaling pathway [PATH:ko04920]
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03320 PPAR signaling pathway [PATH:ko03320]
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04912 GnRH signaling pathway [PATH:ko04912]
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K05252 GNRH; gonadotropin-releasing hormone
K04280 GNRHR; gonadotropin-releasing hormone receptor
K04632 GNAS; guanine nucleotide-binding protein G(s) subunit alpha
K08041 ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042 ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08043 ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
K08044 ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045 ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046 ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047 ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048 ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049 ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K04374 ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
K04634 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
K04635 GNA11; guanine nucleotide-binding protein subunit alpha-11
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K04958 ITPR1; inositol 1,4,5-triphosphate receptor type 1
K04959 ITPR2; inositol 1,4,5-triphosphate receptor type 2
K04960 ITPR3; inositol 1,4,5-triphosphate receptor type 3
K02183 CALM; calmodulin
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04850 CACNA1C; voltage-dependent calcium channel L type alpha-1C
K04851 CACNA1D; voltage-dependent calcium channel L type alpha-1D
K04853 CACNA1F; voltage-dependent calcium channel L type alpha-1F
K04857 CACNA1S; voltage-dependent calcium channel L type alpha-1S
K04416 MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
K04420 MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2 [EC:2.7.11.25]
K04421 MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]
K04428 MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25]
K04432 MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
K04433 MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04464 MAPK7, ERK5; mitogen-activated protein kinase 7 [EC:2.7.11.24]
K16342 PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
K04393 CDC42; cell division control protein 42
K04430 MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
K04431 MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K04448 JUN; transcription factor AP-1
K08521 LHB; luteinizing hormone beta polypeptide
K08522 CGA; glycoprotein hormones, alpha polypeptide
K05250 FSH; follicle stimulating hormone
K05871 PTK2B, FAK2; focal adhesion kinase 2 [EC:2.7.10.2]
K01398 MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
K07763 MMP14; matrix metalloproteinase-14 (membrane-inserted) [EC:3.4.24.80]
K08523 HBEGF; heparin-binding EGF-like growth factor
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K04364 GRB2; growth factor receptor-binding protein 2
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS, KRAS2; GTPase KRas
K07828 NRAS; GTPase NRas
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K04375 ELK1; ETS domain-containing protein Elk-1
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04913 Ovarian Steroidogenesis [PATH:ko04913]
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04915 Estrogen signaling pathway [PATH:ko04915]
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04914 Progesterone-mediated oocyte maturation [PATH:ko04914]
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04917 Prolactin signaling pathway [PATH:ko04917]
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04916 Melanogenesis [PATH:ko04916]
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04614 Renin-angiotensin system [PATH:ko04614]
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Circulatory system
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Digestive system
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Excretory system
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Nervous system
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04724 Glutamatergic synapse [PATH:ko04724]
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04727 GABAergic synapse [PATH:ko04727]
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04725 Cholinergic synapse [PATH:ko04725]
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04728 Dopaminergic synapse [PATH:ko04728]
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04726 Serotonergic synapse [PATH:ko04726]
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04720 Long-term potentiation [PATH:ko04720]
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04730 Long-term depression [PATH:ko04730]
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04723 Retrograde endocannabinoid signaling [PATH:ko04723]
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04721 Synaptic vesicle cycle [PATH:ko04721]
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04722 Neurotrophin signaling pathway [PATH:ko04722]
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K02582 NGFB; nerve growth factor, beta
K04355 BDNF; brain-derived neurotrophic factor
K12457 NTF4; neurotrophin 4
K04356 NTF3; neurotrophin 3
K03176 NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K04360 NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]
K05101 NTRK3, TRKC; neurotrophic tyrosine kinase, receptor type 3 [EC:2.7.10.1]
K07193 APS, SH2B2; SH2B adapter protein 2
K12459 SH2B1_3; SH2B adaptor protein 1/3
K04364 GRB2; growth factor receptor-binding protein 2
K03099 SOS; son of sevenless
K02833 HRAS; GTPase HRas
K07827 KRAS, KRAS2; GTPase KRas
K07828 NRAS; GTPase NRas
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK1_2; extracellular signal-regulated kinase 1/2 [EC:2.7.11.24]
K04373 RPS6KA, RSK2; p90 ribosomal S6 kinase [EC:2.7.11.1]
K04445 MSK1, RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
K04374 ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
K02161 BCL2; apoptosis regulator BCL-2
K12460 KIDINS220, ARMS; ankyrin repeat-rich membrane spanning protein
K12461 FRS2; fibroblast growth factor receptor substrate 2
K04438 CRK, CRKII; proto-oncogene C-crk
K06277 RAPGEF1, GRF2; Rap guanine nucleotide exchange factor (GEF) 1
K04353 RAP1A; Ras-related protein Rap-1A
K07836 RAP1B; Ras-related protein Rap-1B
K04421 MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]
K04463 MAP2K5, MEK5; mitogen-activated protein kinase kinase 5 [EC:2.7.12.2]
K04464 MAPK7, ERK5; mitogen-activated protein kinase 7 [EC:2.7.11.24]
K04441 P38; p38 MAP kinase [EC:2.7.11.24]
K04443 MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
K06279 SHC; src homology 2 domain-containing transforming protein C
K09593 GAB1; GRB2-associated-binding protein 1
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K02581 NFKBIB; NF-kappa-B inhibitor beta
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K05872 NFKBIE; NF-kappa-B inhibitor epsilon
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K09408 FOXO3; forkhead box protein O3
K04389 TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
K02158 BAD; BCL2-antagonist of cell death
K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K12077 PDK1; pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2]
K16172 IRS1; insulin receptor substrate 1
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K02183 CALM; calmodulin
K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K05869 CAMK4; calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]
K06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K07293 PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
K08888 MATK; megakaryocyte-associated tyrosine kinase [EC:2.7.10.2]
K02583 NGFR; nerve growth factor receptor (TNFR superfamily member 16)
K12462 ARHGDI, RHOGDI; Rho GDP-dissociation inhibitor
K04513 RHOA, RHO1; Ras homolog gene family, member A
K04393 CDC42; cell division control protein 42
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K04416 MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
K04426 MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04431 MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04440 JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
K04448 JUN; transcription factor AP-1
K04451 TP53, P53; tumor protein p53
K02159 BAX; apoptosis regulator BAX
K10148 TP73; tumor protein p73
K03175 TRAF6; TNF receptor-associated factor 6
K12458 ZNF274; zinc finger protein 274
K12463 PRDM4; PR domain zinc finger protein 4
K12464 MAGED1, NRAGE; melanoma-associated antigen D1
K12465 NGFRAP1; nerve growth factor receptor-associated protein 1
K06630 YWHAE; 14-3-3 protein epsilon
K08846 RIPK2; receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]
K04730 IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
K04731 IRAK2; interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1]
K04732 IRAK3; interleukin-1 receptor-associated kinase 3 [EC:2.7.11.1]
K04733 IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K12388 SORT1; sortilin
K04505 PSEN1, PS1; presenilin 1 [EC:3.4.23.-]
K04522 PSEN2, PS2; presenilin 2 [EC:3.4.23.-]
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Sensory system
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Development
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Environmental adaptation
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Human Diseases
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KEGG Orthology (KO)