KEGG Orthology (KO)

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   Membrane transport
 
   Signal transduction
     02020 Two-component system [PATH:ko02020]
     02022 Two-component system [BR:ko02022]
     04014 Ras signaling pathway [PATH:ko04014]
       K04357  EGF; epidermal growth factor
       K18496  FGF1; fibroblast growth factor 1
       K18497  FGF2; fibroblast growth factor 2
       K04358  FGF; fibroblast growth factor
       K05451  NGFA; nerve growth factor, alpha
       K02582  NGFB; nerve growth factor, beta
       K04526  INS; insulin
       K05459  IGF1; insulin-like growth factor 1
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K05450  PDGFC_D; platelet derived growth factor C/D
       K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
       K05461  KITLG; KIT ligand
       K05448  VEGFA; vascular endothelial growth factor A
       K16858  VEGFB; vascular endothelial growth factor B
       K16859  PGF; placenta growth factor
       K05449  VEGFC_D; vascular endothelial growth factor C/D
       K05460  HGF; hepatocyte growth factor
       K05465  ANGPT1; angiopoietin 1
       K05466  ANGPT2; angiopoietin 2
       K05467  ANGPT4; angiopoietin 4
       K05462  EFNA; ephrin-A
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K04362  FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K05093  FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
       K05094  FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
       K05095  FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
       K02583  NGFR; nerve growth factor receptor (TNFR superfamily member 16)
       K04527  INSR; insulin receptor [EC:2.7.10.1]
       K05087  IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K04363  PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K05090  CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
       K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
       K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
       K05098  KDR, VEGFR2; kinase insert domain protein receptor [EC:2.7.10.1]
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
       K05121  TEK, TIE2; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]
       K05103  EPHA2, ECK; Eph receptor A2 [EC:2.7.10.1]
       K04364  GRB2; growth factor receptor-binding protein 2
       K09593  GAB1; GRB2-associated-binding protein 1
       K08091  GAB2; growth factor receptor bound protein 2-associated protein 2
       K06279  SHC1; SHC- transforming protein 1
       K17447  SHC2; SHC- transforming protein 2
       K17448  SHC3; SHC- transforming protein 3
       K17449  SHC4; SHC- transforming protein 4
       K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
       K03099  SOS; son of sevenless
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K04350  RASGRP1; RAS guanyl-releasing protein 1
       K12361  RASGRP2; RAS guanyl-releasing protein 2
       K12362  RASGRP3; RAS guanyl-releasing protein 3
       K12363  RASGRP4; RAS guanyl-releasing protein 4
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K07360  ZAP70; tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]
       K07362  LAT; linker for activation of T cells
       K04163  HTR7; 5-hydroxytryptamine receptor 7
       K04536  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
       K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
       K07825  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
       K04538  GNB4; guanine nucleotide-binding protein subunit beta-4
       K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
       K07826  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
       K04540  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
       K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
       K04542  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
       K04543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
       K04544  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
       K04545  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
       K04546  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K04547  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
       K04548  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
       K04549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K04349  RASGRF1; Ras-specific guanine nucleotide-releasing factor 1
       K12326  RASGRF2; Ras-specific guanine nucleotide-releasing factor 2
       K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
       K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
       K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
       K02183  CALM; calmodulin
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K07831  MRAS; Ras-related protein M-Ras
       K07829  RRAS; Ras-related protein R-Ras
       K07830  RRAS2, TC21; Ras-related protein R-Ras2
       K08052  NF1; neurofibromin 1
       K04352  RASA1, RASGAP; Ras GTPase-activating protein 1
       K08053  RASA2, GAP1M; Ras GTPase-activating protein 2
       K12380  RASA3; Ras GTPase-activating protein 3
       K17630  RASA4, CAPRI; Ras GTPase-activating protein 4
       K17631  SYNGAP, RASA5; Ras/Rap GTPase-activating protein SynGAP
       K17632  RASAL1; RAS protein activator-like 1
       K17633  RASAL2; RAS protein activator-like 2
       K17634  RASAL3; RAS protein activator-like 3
       K09850  RASSF1; Ras association domain-containing protein 1
       K08015  RASSF5, RAPL; Ras association domain-containing protein 5
       K04411  STK4, MST1; serine/threonine kinase 4
       K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
       K04410  PAK2; p21-activated kinase 2 [EC:2.7.11.1]
       K05733  PAK3, MRX30; p21-activated kinase 3 [EC:2.7.11.1]
       K05734  PAK4; p21-activated kinase 4 [EC:2.7.11.1]
       K05735  PAK6; p21-activated kinase 6 [EC:2.7.11.1]
       K05736  PAK7; p21-activated kinase 7 [EC:2.7.11.1]
       K04513  RHOA; Ras homolog gene family, member A
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K02158  BAD; BCL2-antagonist of cell death
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K12358  FOXO4; forkhead box protein O4
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K05702  AF6, MLLT4; afadin
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K13618  PLA1A; phospholipase A1 member A [EC:3.1.1.-]
       K01047  PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]
       K16342  PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]
       K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2 [EC:3.1.1.4]
       K16817  PLA2G16; HRAS-like suppressor 3 [EC:3.1.1.32 3.1.1.4]
       K04375  ELK1; ETS domain-containing protein Elk-1
       K02678  ETS, pnt; c-ets proto-oncogene protein
       K10632  BRAP; BRCA1-associated protein [EC:6.3.2.19]
       K14958  KSR1; kinase suppressor of Ras 1
       K18529  KSR2; kinase suppressor of Ras 2 [EC:2.7.11.1]
       K08019  RAPGEF5; Rap guanine nucleotide exchange factor 5
       K04353  RAP1A; Ras-related protein Rap-1A
       K07836  RAP1B; Ras-related protein Rap-1B
       K08732  RALGDS; ral guanine nucleotide dissociation stimulator
       K17635  RGL1, RGL; ral guanine nucleotide dissociation stimulator-like 1
       K17636  RGL2; ral guanine nucleotide dissociation stimulator-like 2
       K07834  RALA; Ras-related protein Ral-A
       K07835  RALB; Ras-related protein Ral-B
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K17637  EXOC2, SEC5; exocyst complex component 2
       K05410  TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
       K09254  REL; c-Rel proto-oncogene protein
       K01115  PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
       K08773  RALBP1; RalA-binding protein 1
       K04393  CDC42; cell division control protein 42
       K05860  PLCE; phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
       K17638  RIN1; Ras and Rab interactor 1
       K06619  ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
       K08887  ABL2; abelson tyrosine-protein kinase 2 [EC:2.7.10.2]
       K07887  RAB5A; Ras-related protein Rab-5A
       K07888  RAB5B; Ras-related protein Rab-5B
       K07889  RAB5C; Ras-related protein Rab-5C
       K07941  ARF6; ADP-ribosylation factor 6
     04015 Rap1 signaling pathway [PATH:ko04015]
     04010 MAPK signaling pathway [PATH:ko04010]
     04013 MAPK signaling pathway - fly [PATH:ko04013]
     04011 MAPK signaling pathway - yeast [PATH:ko04011]
     04012 ErbB signaling pathway [PATH:ko04012]
     04310 Wnt signaling pathway [PATH:ko04310]
     04330 Notch signaling pathway [PATH:ko04330]
     04340 Hedgehog signaling pathway [PATH:ko04340]
     04350 TGF-beta signaling pathway [PATH:ko04350]
     04390 Hippo signaling pathway [PATH:ko04390]
     04391 Hippo signaling pathway -fly [PATH:ko04391]
     04370 VEGF signaling pathway [PATH:ko04370]
     04630 Jak-STAT signaling pathway [PATH:ko04630]
       K00431  TPO; thyroid peroxidase [EC:1.11.1.8]
       K05437  EPO; erythropoietin
       K05438  GH; growth hormone
       K05439  PRL; prolactin
       K04687  IFNG; interferon gamma
       K05414  IFNA; interferon alpha
       K05415  IFNB; interferon beta
       K05440  IFNW1; interferon, omega 1
       K05441  IFNK; interferon, kappa
       K05442  IFNT1; interferon, tau-1
       K05443  IL10, CSIF; interleukin 10
       K05444  IL19_20_24; interleukin 19/20/24
       K05445  IL22, IL-TIF; interleukin 22
       K05446  IL26; interleukin 26
       K05447  IL28_29, IFNL; interleukin 28/29 (interferon, lambda)
       K04736  IL3; interleukin 3
       K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
       K05428  IL5; interleukin 5
       K05429  IL2; interleukin 2
       K05430  IL4; interleukin 4
       K05431  IL7; interleukin 7
       K05432  IL9; interleukin 9
       K05433  IL15; interleukin 15
       K05434  IL21; interleukin 21
       K05435  IL13; interleukin 13
       K05436  TSLP; thymic stromal lymphopoietin
       K05405  IL6; interleukin 6
       K05406  IL12A; interleukin 12A
       K05417  IL11; interleukin 11
       K05418  OSM; oncostatin M
       K05419  LIF; leukemia inhibitory factor
       K05420  CNTF; ciliary neurotrophic factor
       K05421  BSF3, CLC; B-cell stimulating factor 3
       K05422  CTF1, CT1; cardiotrophin 1
       K05423  CSF3, GCSF; granulocyte colony-stimulating factor
       K05424  LEP; leptin
       K05425  IL12B; interleukin 12B
       K05426  IL23A; interleukin 23, alpha subunit p19
       K04737  IL3RA; interleukin 3 receptor alpha
       K04738  CSF2RB, IL3RB; cytokine receptor common subunit beta
       K05055  IL6R; interleukin 6 receptor
       K05056  IL11RA; interleukin 11 receptor alpha
       K05057  OSMR; oncostatin M receptor
       K05058  LIFR; leukemia inhibitory factor receptor
       K05059  CNTFR; ciliary neurotrophic factor receptor
       K05060  IL6ST, GP130; interleukin 6 signal transducer
       K05061  CSF3R; granulocyte colony-stimulating factor receptor
       K05062  LEPR; leptin receptor
       K05063  IL12RB1; interleukin 12 receptor beta-1
       K05064  IL12RB2; interleukin 12 receptor beta-2
       K05065  IL23R; interleukin 23 receptor
       K05066  CSF2RA, GMCSFR; granulocyte-macrophage colony-stimulating factor receptor alpha
       K05067  IL5RA; interleukin 5 receptor alpha
       K05068  IL2RA, CD25; interleukin 2 receptor alpha
       K05069  IL2RB; interleukin 2 receptor beta
       K05070  IL2RG; interleukin 2 receptor gamma
       K05071  IL4R; interleukin 4 receptor
       K05072  IL7R; interleukin 7 receptor
       K05073  IL9R; interleukin 9 receptor
       K05074  IL15RA; interleukin 15 receptor alpha
       K05075  IL21R; interleukin 21 receptor
       K05076  IL13RA1; interleukin 13 receptor alpha-1
       K05077  IL13RA2; interleukin 13 receptor alpha-2
       K05078  TSLPR; thymic stromal-derived lymphopoietin receptor
       K05079  EPOR; erythropoietin receptor
       K05080  GHR; growth hormone receptor
       K05081  PRLR; prolactin receptor
       K05082  TPOR, MPL; thrombopoietin receptor
       K05130  IFNAR1; interferon receptor 1
       K05131  IFNAR2; interferon receptor 2
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K05134  IL10RA; interleukin 10 receptor alpha
       K05135  IL10RB; interleukin 10 receptor beta
       K05136  IL20RA; interleukin 20 receptor alpha
       K05137  IL20RB; interleukin 20 receptor beta
       K05138  IL22RA1; interleukin 22 receptor alpha 1
       K05139  IL22RA2; interleukin 22 receptor alpha 2
       K05140  IL28RA; interleukin 28 receptor alpha
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
       K11218  JAK3; Janus kinase 3 [EC:2.7.10.2]
       K11219  TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
       K11220  STAT1; signal transducer and activator of transcription 1
       K11221  STAT2; signal transducer and activator of transcription 2
       K04692  STAT3; signal transducer and activator of transcription 3
       K11222  STAT4; signal transducer and activator of transcription 4
       K11223  STAT5A; signal transducer and activator of transcription 5A
       K11224  STAT5B; signal transducer and activator of transcription 5B
       K11225  STAT6; signal transducer and activator of transcription 6
       K04693  IRF9, ISGF3G, P48; interferon regulatory factor 9
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K04694  SOCS1, JAB; suppressor of cytokine signaling 1
       K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
       K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
       K04697  SOCS4; suppressor of cytokine signaling 4
       K04698  SOCS5; suppressor of cytokine signaling 5
       K04699  SOCS7, NAP4; suppressor of cytokine signaling 7
       K04700  SOCSN; suppressor of cytokine signaling, invertebrate
       K04701  CISH; cytokine inducible SH2-containing protein
       K04702  PIM1; proto-oncogene serine/threonine-protein kinase Pim-1 [EC:2.7.11.1]
       K04377  MYC; Myc proto-oncogene protein
       K04503  CCND1; cyclin D1
       K10151  CCND2; cyclin D2
       K10152  CCND3; cyclin D3
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K04703  SPRED; sprouty-related, EVH1 domain-containing protein
       K04704  SPRY1; protein sprouty homolog 1
       K17383  SPRY2; protein sprouty homolog 2
       K17385  SPRY4; protein sprouty homolog 4
       K04705  STAM; signal transducing adaptor molecule
       K04706  PIAS1; E3 SUMO-protein ligase PIAS1 [EC:6.3.2.-]
       K16063  PIAS2; E3 SUMO-protein ligase PIAS2 [EC:6.3.2.-]
       K16064  PIAS3; E3 SUMO-protein ligase PIAS3 [EC:6.3.2.-]
       K16065  PIAS4; E3 SUMO-protein ligase PIAS4 [EC:6.3.2.-]
       K04707  CBL; E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
       K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
       K04364  GRB2; growth factor receptor-binding protein 2
       K03099  SOS; son of sevenless
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]
     04064 NF-kappa B signaling pathway [PATH:ko04064]
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K05856  LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
       K07360  ZAP70; tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]
       K07362  LAT; linker for activation of T cells
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K18052  PRKCQ; novel protein kinase C theta type [EC:2.7.11.13]
       K06856  IGH; immunoglobulin heavy chain
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K05854  LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
       K07371  BLNK; B-cell linker protein
       K07370  BTK; Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K07367  CARD11; caspase recruitment domain-containing protein 11
       K07368  BCL10; B-cell CLL/lymphoma 10
       K07369  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
       K04519  IL1B; interleukin 1 beta
       K04386  IL1R1; interleukin 1 receptor type I
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K04730  IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K03175  TRAF6; TNF receptor-associated factor 6
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K03158  TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
       K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K03173  TRAF2; TNF receptor-associated factor 2
       K09849  TRAF5; TNF receptor-associated factor 5
       K16060  BIRC2_3; baculoviral IAP repeat-containing protein 2/3
       K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58 [EC:3.6.3.14]
       K10652  TRIM25, EFP; tripartite motif-containing protein 25 [EC:6.3.2.19]
       K05399  LBP; lipopolysaccharide-binding protein
       K04391  CD14; CD14 antigen
       K10160  TLR4; toll-like receptor 4
       K05400  LY96, MD-2; lymphocyte antigen 96
       K05403  TIRAP; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
       K05409  TIRP, TRAM; TRIF-related adaptor molecule
       K05842  TRIF; toll-like receptor adapter molecule 1
       K03161  TNFSF5, CD40L; tumor necrosis factor ligand superfamily member 5
       K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
       K03174  TRAF3; TNF receptor-associated factor 3
       K05473  TNFSF11, RANKL; tumor necrosis factor ligand superfamily member 11
       K05147  TNFRSF11A, RANK; tumor necrosis factor receptor superfamily member 11A
       K05468  LTA, TNFB; lymphotoxin alpha (TNF superfamily, member 1)
       K03157  LTB, TNFC; lymphotoxin beta (TNF superfamily, member 3)
       K05477  TNFSF14, LIGHT; tumor necrosis factor ligand superfamily member 14
       K03159  TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3
       K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K04403  MAP3K7IP1, TAB1; TAK1-binding protein 1
       K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
       K12793  MAP3K7IP3, TAB3; TAK1-binding protein 3
       K05476  TNFSF13B, TNFSF20; tumor necrosis factor ligand superfamily member 13B
       K05151  TNFRSF13C, BAFFR; tumor necrosis factor receptor superfamily member 13C
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K16065  PIAS4; E3 SUMO-protein ligase PIAS4 [EC:6.3.2.-]
       K10577  UBE2I, UBC9; ubiquitin-conjugating enzyme E2 I [EC:6.3.2.19]
       K04728  ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
       K10130  LRDD, PIDD; leucine-rich repeats and death domain-containing protein
       K16072  ERC1; ELKS/RAB6-interacting/CAST family member 1
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
       K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K02161  BCL2; apoptosis regulator BCL-2
       K03172  TRAF1; TNF receptor-associated factor 1
       K02162  BCL2A1; hematopoietic BCL2-related protein A1
       K04469  NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
       K10030  IL8, CXCL8; interleukin 8
       K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3 [EC:3.4.19.12 6.3.2.19]
       K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
       K12964  CCL4; C-C motif chemokine 4
       K06527  VCAM1; vascular cell adhesion molecule 1
       K01348  PLAU; urokinase plasminogen activator [EC:3.4.21.73]
       K03097  CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]
       K03115  CSNK2B; casein kinase II subunit beta
       K09253  RELB; transcription factor RelB
       K16595  CCL13; C-C motif chemokine 13
       K05512  CCL19, ELC; C-C motif chemokine 19
       K16062  CCL21, SLC; C-C motif chemokine 21
       K10031  CXCL12; C-X-C motif chemokine 12
       K06490  ICAM1; intercellular adhesion molecule 1
     04668 TNF signaling pathway [PATH:ko04668]
     04066 HIF-1 signaling pathway [PATH:ko04066]
     04068 FoxO signaling pathway [PATH:ko04068]
     04020 Calcium signaling pathway [PATH:ko04020]
     04070 Phosphatidylinositol signaling system [PATH:ko04070]
     04024 cAMP signaling pathway [PATH:ko04024]
     04022 cGMP - PKG signaling pathway [PATH:ko04022]
     04151 PI3K-Akt signaling pathway [PATH:ko04151]
       K04357  EGF; epidermal growth factor
       K18496  FGF1; fibroblast growth factor 1
       K18497  FGF2; fibroblast growth factor 2
       K04358  FGF; fibroblast growth factor
       K05451  NGFA; nerve growth factor, alpha
       K02582  NGFB; nerve growth factor, beta
       K04526  INS; insulin
       K05459  IGF1; insulin-like growth factor 1
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K05450  PDGFC_D; platelet derived growth factor C/D
       K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
       K05461  KITLG; KIT ligand
       K05448  VEGFA; vascular endothelial growth factor A
       K16858  VEGFB; vascular endothelial growth factor B
       K16859  PGF; placenta growth factor
       K05449  VEGFC_D; vascular endothelial growth factor C/D
       K05460  HGF; hepatocyte growth factor
       K05465  ANGPT1; angiopoietin 1
       K05466  ANGPT2; angiopoietin 2
       K05467  ANGPT4; angiopoietin 4
       K05462  EFNA; ephrin-A
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K04362  FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K05093  FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
       K05094  FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
       K05095  FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
       K02583  NGFR; nerve growth factor receptor (TNFR superfamily member 16)
       K04527  INSR; insulin receptor [EC:2.7.10.1]
       K05087  IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K04363  PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K05090  CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
       K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
       K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
       K05098  KDR, VEGFR2; kinase insert domain protein receptor [EC:2.7.10.1]
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
       K05121  TEK, TIE2; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]
       K05103  EPHA2, ECK; Eph receptor A2 [EC:2.7.10.1]
       K04364  GRB2; growth factor receptor-binding protein 2
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K16172  IRS1; insulin receptor substrate 1
       K10159  TLR2; toll-like receptor 2
       K10160  TLR4; toll-like receptor 4
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K06856  IGH; immunoglobulin heavy chain
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K06465  CD19; CD19 antigen
       K12230  PIK3AP1, BCAP; phosphoinositide 3-kinase adapter protein 1
       K05438  GH; growth hormone
       K05439  PRL; prolactin
       K05418  OSM; oncostatin M
       K05429  IL2; interleukin 2
       K04736  IL3; interleukin 3
       K05405  IL6; interleukin 6
       K05430  IL4; interleukin 4
       K05431  IL7; interleukin 7
       K05414  IFNA; interferon alpha
       K05415  IFNB; interferon beta
       K05437  EPO; erythropoietin
       K05423  CSF3, GCSF; granulocyte colony-stimulating factor
       K05080  GHR; growth hormone receptor
       K05081  PRLR; prolactin receptor
       K05057  OSMR; oncostatin M receptor
       K05068  IL2RA, CD25; interleukin 2 receptor alpha
       K05069  IL2RB; interleukin 2 receptor beta
       K05070  IL2RG; interleukin 2 receptor gamma
       K04737  IL3RA; interleukin 3 receptor alpha
       K05055  IL6R; interleukin 6 receptor
       K05071  IL4R; interleukin 4 receptor
       K05072  IL7R; interleukin 7 receptor
       K05130  IFNAR1; interferon receptor 1
       K05131  IFNAR2; interferon receptor 2
       K05079  EPOR; erythropoietin receptor
       K05061  CSF3R; granulocyte colony-stimulating factor receptor
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
       K11218  JAK3; Janus kinase 3 [EC:2.7.10.2]
       K06236  COL1AS; collagen, type I/II/III/V/XI/XXIV/XXVII, alpha
       K06237  COL4A; collagen, type IV, alpha
       K06238  COL6A; collagen, type VI, alpha
       K05637  LAMA1_2; laminin, alpha 1/2
       K06240  LAMA3_5; laminin, alpha 3/5
       K06241  LAMA4; laminin, alpha 4
       K05636  LAMB1; laminin, beta 1
       K06243  LAMB2; laminin, beta 2
       K06244  LAMB3; laminin, beta 3
       K06245  LAMB4; laminin, beta 4
       K05635  LAMC1; laminin, gamma 1
       K06246  LAMC2; laminin, gamma 2
       K06247  LAMC3; laminin, gamma 3
       K06248  CHAD; chondroadherin
       K06249  RELN; reelin [EC:3.4.21.-]
       K16857  THBS1; thrombospondin 1
       K04659  THBS2S; thrombospondin 2/3/4/5
       K05717  FN1; fibronectin 1
       K06250  SPP1, BNSP, OPN; secreted phosphoprotein 1
       K06251  VTN; vitronectin
       K06252  TN; tenascin
       K03900  VWF; von Willebrand factor
       K06253  IBSP; integrin binding sialoprotein
       K06480  ITGA1; integrin alpha 1
       K06481  ITGA2; integrin alpha 2
       K06476  ITGA2B; integrin alpha 2B
       K06482  ITGA3; integrin alpha 3
       K06483  ITGA4; integrin alpha 4
       K06484  ITGA5; integrin alpha 5
       K06485  ITGA6; integrin alpha 6
       K06583  ITGA7; integrin alpha 7
       K06584  ITGA8; integrin alpha 8
       K06585  ITGA9; integrin alpha 9
       K06586  ITGA10; integrin alpha 10
       K06587  ITGA11; integrin alpha 11
       K06487  ITGAV; integrin alpha V
       K05719  ITGB1; integrin beta 1
       K06493  ITGB3; integrin beta 3
       K06525  ITGB4; integrin beta 4
       K06588  ITGB5; integrin beta 5
       K06589  ITGB6; integrin beta 6
       K06590  ITGB7; integrin beta 7
       K06591  ITGB8; integrin beta 8
       K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
       K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
       K04129  CHRM1; muscarinic acetylcholine receptor M1
       K04130  CHRM2; muscarinic acetylcholine receptor M2
       K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
       K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
       K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
       K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
       K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
       K04273  LPAR6, P2RY5; lysophosphatidic acid receptor 6
       K04536  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
       K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
       K07825  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
       K04538  GNB4; guanine nucleotide-binding protein subunit beta-4
       K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
       K07826  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
       K04540  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
       K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
       K04542  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
       K04543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
       K04544  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
       K04545  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
       K04546  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K04547  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
       K04548  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
       K04549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
       K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
       K07298  STK11, LKB1; serine/threonine-protein kinase 11
       K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
       K08270  DDIT4, REDD1; DNA-damage-inducible transcript 4
       K07206  TSC1; tuberous sclerosis 1
       K07207  TSC2; tuberous sclerosis 2
       K07208  RHEB; Ras homolog enriched in brain
       K08266  GBL; G protein beta subunit-like
       K07203  FRAP; FKBP12-rapamycin complex-associated protein
       K07204  RAPTOR; regulatory associated protein of mTOR
       K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
       K03259  EIF4E; translation initiation factor 4E
       K04688  RPS6KB; p70 ribosomal S6 kinase [EC:2.7.11.1]
       K03258  EIF4B; translation initiation factor 4B
       K02991  RP-S6e, RPS6; small subunit ribosomal protein S6e
       K06071  PKN; protein kinase N [EC:2.7.11.13]
       K13302  SGK1; serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
       K13303  SGK2; serum/glucocorticoid-regulated kinase 2 [EC:2.7.11.1]
       K13304  SGK3; serum/glucocorticoid-regulated kinase 3 [EC:2.7.11.1]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
       K16339  THEM4, CTMP; thioesterase superfamily member 4
       K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
       K03456  PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
       K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
       K11583  PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
       K11584  PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
       K04079  htpG, HSP90A; molecular chaperone HtpG
       K09487  HSP90B, TRA1; heat shock protein 90kDa beta
       K09554  CDC37; cell division cycle protein 37
       K16333  CRTC2, TORC2; CREB-regulated transcription coactivator 2
       K16340  PHLPP; PH domain and leucine-rich repeat-containing protein phosphatase [EC:3.1.3.16]
       K10167  TCL1A; T-cell leukemia/lymphoma 1A
       K16836  TCL1B; T-cell leukemia/lymphoma 1B
       K16837  MTCP1; mature T-cell proliferation-1 type B1
       K13242  NOS3; nitric-oxide synthase, endothelial [EC:1.14.13.39]
       K10605  BRCA1; breast cancer type 1 susceptibility protein
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K00693  GYS; glycogen(starch) synthase [EC:2.4.1.11]
       K01596  E4.1.1.32, pckA, PEPCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
       K01084  G6PC; glucose-6-phosphatase [EC:3.1.3.9]
       K04377  MYC; Myc proto-oncogene protein
       K04503  CCND1; cyclin D1
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K10151  CCND2; cyclin D2
       K10152  CCND3; cyclin D3
       K06626  CCNE; cyclin E
       K09408  FOXO3; forkhead box protein O3
       K16332  RBL2; retinoblastoma-like protein 2
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K16341  BCL2L11, BIM; Bcl-2-like protein 11
       K16197  YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
       K06630  YWHAE; 14-3-3 protein epsilon
       K16198  YWHAG_H; 14-3-3 protein gamma/eta
       K02158  BAD; BCL2-antagonist of cell death
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K02161  BCL2; apoptosis regulator BCL-2
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1
       K08524  NR2B1, RXRA; retinoid X receptor alpha
       K04465  NR4A1, HMR; nuclear receptor subfamily 4 group A member 1
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K04735  RELA; transcription factor p65
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K09420  MYB; myb proto-oncogene protein
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
       K04451  TP53, P53; tumor protein p53
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
     04152 AMPK signaling pathway [PATH:ko04152]
     04150 mTOR signaling pathway [PATH:ko04150]
     04075 Plant hormone signal transduction [PATH:ko04075]
 
   Signaling molecules and interaction
 
 Cellular Processes
 
   Transport and catabolism
 
   Cell motility
 
   Cell growth and death
     04110 Cell cycle [PATH:ko04110]
     04111 Cell cycle - yeast [PATH:ko04111]
     04112 Cell cycle - Caulobacter [PATH:ko04112]
     04113 Meiosis - yeast [PATH:ko04113]
     04114 Oocyte meiosis [PATH:ko04114]
     04210 Apoptosis [PATH:ko04210]
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
       K04721  TNFSF10, TRAIL; tumor necrosis factor ligand superfamily member 10
       K04722  TNFRSF10, TRAILR; tumor necrosis factor receptor superfamily member 10
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K03158  TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
       K04383  IL1A; interleukin 1 alpha
       K04519  IL1B; interleukin 1 beta
       K04386  IL1R1; interleukin 1 receptor type I
       K04723  IL1RAP; interleukin 1 receptor accessory protein
       K02373  FADD; FAS-associated death domain protein
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
       K04400  CASP10; caspase 10 [EC:3.4.22.63]
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K04397  CASP7; caspase 7 [EC:3.4.22.60]
       K04396  CASP6; caspase 6 [EC:3.4.22.59]
       K16060  BIRC2_3; baculoviral IAP repeat-containing protein 2/3
       K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
       K16061  BIRC7_8; baculoviral IAP repeat-containing protein 7/8
       K04726  BID; BH3 interacting domain death agonist
       K02161  BCL2; apoptosis regulator BCL-2
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K08738  CYC; cytochrome c
       K02084  APAF1; apoptotic protease-activating factor
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K02310  DFFA, DFF45; DNA fragmentation factor, 45 kD, alpha subunit
       K02311  DFFB, DFF40; DNA fragmentation factor, 40 kD, beta subunit [EC:3.-.-.-]
       K04727  PDCD8, AIF; programmed cell death 8 (apoptosis-inducing factor) [EC:1.-.-.-]
       K01173  ENDOG; endonuclease G, mitochondrial
       K04728  ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
       K04451  TP53, P53; tumor protein p53
       K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
       K03173  TRAF2; TNF receptor-associated factor 2
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K04730  IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
       K04731  IRAK2; interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1]
       K04732  IRAK3; interleukin-1 receptor-associated kinase 3 [EC:2.7.11.1]
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K02582  NGFB; nerve growth factor, beta
       K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
       K04736  IL3; interleukin 3
       K04737  IL3RA; interleukin 3 receptor alpha
       K04738  CSF2RB, IL3RB; cytokine receptor common subunit beta
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04739  PRKAR; cAMP-dependent protein kinase regulator
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K02158  BAD; BCL2-antagonist of cell death
       K02159  BAX; apoptosis regulator BAX
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K01367  CAPN1; calpain-1 [EC:3.4.22.52]
       K03853  CAPN2; calpain-2 [EC:3.4.22.53]
       K04741  CASP12; caspase 12 [EC:3.4.22.-]
     04115 p53 signaling pathway [PATH:ko04115]
 
   Cellular commiunity
 
 Organismal Systems
 
 Human Diseases
 
   Cancers
     05200 Pathways in cancer [PATH:ko05200]
       K06765  DCC; deleted in colorectal carcinoma
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K08733  APPL, DIP13A; DCC-interacting protein 13 alpha
       K05689  CDHE, CDH1; cadherin 1, type 1, E-cadherin
       K02105  CTNNB1; catenin beta 1
       K05691  CTNNA; catenin alpha
       K02157  AXIN1; axin 1
       K04385  AXIN2; axin 2
       K02085  APC; adenomatosis polyposis coli protein
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K02620  TCF7; transcription factor 7
       K04490  TCF7L1; transcription factor 7-like 1
       K04491  TCF7L2; transcription factor 7-like 2
       K04492  LEF1; lymphoid enhancer-binding factor 1
       K08731  BIRC5; baculoviral IAP repeat-containing protein 5
       K04377  MYC; Myc proto-oncogene protein
       K04503  CCND1; cyclin D1
       K03209  WNT1; wingless-type MMTV integration site family, member 1
       K00182  WNT2; wingless-type MMTV integration site family, member 2
       K00312  WNT3; wingless-type MMTV integration site family, member 3
       K00408  WNT4; wingless-type MMTV integration site family, member 4
       K00444  WNT5; wingless-type MMTV integration site family, member 5
       K00445  WNT6; wingless-type MMTV integration site family, member 6
       K00572  WNT7; wingless-type MMTV integration site family, member 7
       K00714  WNT8; wingless-type MMTV integration site family, member 8
       K01064  WNT9; wingless-type MMTV integration site family, member 9
       K01357  WNT10; wingless-type MMTV integration site family, member 10
       K01384  WNT11; wingless-type MMTV integration site family, member 11
       K01558  WNT16; wingless-type MMTV integration site family, member 16
       K02432  FZD1_7, fz; frizzled 1/7
       K02235  FZD2; frizzled 2
       K02329  FZD3; frizzled 3
       K02354  FZD4, fz4; frizzled 4
       K02375  FZD5_8, fz2; frizzled 5/8
       K02376  FZD6; frizzled 6
       K02842  FZD9_10; frizzled 9/10
       K02353  DVL; segment polarity protein dishevelled
       K06237  COL4A; collagen, type IV, alpha
       K05637  LAMA1_2; laminin, alpha 1/2
       K06240  LAMA3_5; laminin, alpha 3/5
       K06241  LAMA4; laminin, alpha 4
       K05636  LAMB1; laminin, beta 1
       K06243  LAMB2; laminin, beta 2
       K06244  LAMB3; laminin, beta 3
       K06245  LAMB4; laminin, beta 4
       K05635  LAMC1; laminin, gamma 1
       K06246  LAMC2; laminin, gamma 2
       K06247  LAMC3; laminin, gamma 3
       K05717  FN1; fibronectin 1
       K06481  ITGA2; integrin alpha 2
       K06476  ITGA2B; integrin alpha 2B
       K06482  ITGA3; integrin alpha 3
       K06485  ITGA6; integrin alpha 6
       K06487  ITGAV; integrin alpha V
       K05719  ITGB1; integrin beta 1
       K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
       K09348  NKX3-1; homeobox protein Nkx-3.1
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04469  NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
       K04735  RELA; transcription factor p65
       K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
       K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
       K02161  BCL2; apoptosis regulator BCL-2
       K16060  BIRC2_3; baculoviral IAP repeat-containing protein 2/3
       K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
       K16061  BIRC7_8; baculoviral IAP repeat-containing protein 7/8
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K03172  TRAF1; TNF receptor-associated factor 1
       K03173  TRAF2; TNF receptor-associated factor 2
       K03174  TRAF3; TNF receptor-associated factor 3
       K09848  TRAF4; TNF receptor-associated factor 4
       K09849  TRAF5; TNF receptor-associated factor 5
       K03175  TRAF6; TNF receptor-associated factor 6
       K07203  FRAP; FKBP12-rapamycin complex-associated protein
       K02158  BAD; BCL2-antagonist of cell death
       K07201  FOXO1; forkhead box protein O1
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
       K04451  TP53, P53; tumor protein p53
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K08878  BCR1, BCR; breakpoint cluster region protein [EC:2.7.11.1]
       K06619  ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
       K04438  CRK, CRKII; proto-oncogene C-crk
       K04707  CBL; E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
       K11223  STAT5A; signal transducer and activator of transcription 5A
       K11224  STAT5B; signal transducer and activator of transcription 5B
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K04692  STAT3; signal transducer and activator of transcription 3
       K11220  STAT1; signal transducer and activator of transcription 1
       K05448  VEGFA; vascular endothelial growth factor A
       K16858  VEGFB; vascular endothelial growth factor B
       K16859  PGF; placenta growth factor
       K05449  VEGFC_D; vascular endothelial growth factor C/D
       K08774  TGFA; transforming growth factor, alpha
       K04357  EGF; epidermal growth factor
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K04363  PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K05459  IGF1; insulin-like growth factor 1
       K05087  IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K05461  KITLG; KIT ligand
       K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
       K05454  FLT3LG; fms-related tyrosine kinase 3 ligand
       K05092  FLT3, FLK2; fms-related tyrosine kinase 3 [EC:2.7.10.1]
       K05460  HGF; hepatocyte growth factor
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
       K18496  FGF1; fibroblast growth factor 1
       K18497  FGF2; fibroblast growth factor 2
       K04358  FGF; fibroblast growth factor
       K04362  FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K05093  FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
       K05094  FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
       K04364  GRB2; growth factor receptor-binding protein 2
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04448  JUN; transcription factor AP-1
       K04379  FOS; proto-oncogene protein c-fos
       K01388  MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
       K01398  MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
       K01403  MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
       K10030  IL8, CXCL8; interleukin 8
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K05126  RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
       K09288  CCDC6, PTC; coiled-coil domain-containing protein 6
       K09289  NCOA4, PTC3; nuclear receptor coactivator 4
       K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
       K09290  TPM3; tropomyosin 3
       K09291  TPR; nucleoprotein TPR
       K09292  TFG; protein TFG
       K09850  RASSF1; Ras association domain-containing protein 1
       K08015  RASSF5, RAPL; Ras association domain-containing protein 5
       K04411  STK4, MST1; serine/threonine kinase 4
       K08803  DAPK; death-associated protein kinase [EC:2.7.11.1]
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
       K08732  RALGDS; ral guanine nucleotide dissociation stimulator
       K07834  RALA; Ras-related protein Ral-A
       K07835  RALB; Ras-related protein Ral-B
       K08773  RALBP1; RalA-binding protein 1
       K04393  CDC42; cell division control protein 42
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K04513  RHOA; Ras homolog gene family, member A
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K09293  PAX8; paired box protein 8
       K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
       K08524  NR2B1, RXRA; retinoid X receptor alpha
       K08525  NR2B2, RXRB; retinoid X receptor beta
       K08526  NR2B3, RXRG; retinoid X receptor gamma
       K08528  NR1B2, RARB; retinoic acid receptor beta
       K04504  NR1C2, PPARD; peroxisome proliferator-activated receptor delta
       K10056  JUP; junction plakoglobin
       K10055  ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
       K10054  PML, TRIM19; probable transcription factor PML
       K08527  NR1B1, RARA; retinoic acid receptor alpha
       K08367  RUNX1, AML1; runt-related transcription factor 1
       K10053  RUNX1T1, CBFA2T1; runt-related transcription factor 1; translocated to, 1
       K09438  SPI1; transcription factor PU.1
       K09055  CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
       K05066  CSF2RA, GMCSFR; granulocyte-macrophage colony-stimulating factor receptor alpha
       K05061  CSF3R; granulocyte colony-stimulating factor receptor
       K05090  CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K05405  IL6; interleukin 6
       K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
       K17454  E2F1; transcription factor E2F1
       K09389  E2F2; transcription factor E2F2
       K06620  E2F3; transcription factor E2F3
       K04453  MAX; Max protein
       K16063  PIAS2; E3 SUMO-protein ligase PIAS2 [EC:6.3.2.-]
       K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K02219  CKS1; cyclin-dependent kinase regulatory subunit CKS1
       K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
       K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
       K06626  CCNE; cyclin E
       K06618  RB1; retinoblastoma-associated protein
       K09455  MITF; microphthalmia-associated transcription factor
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
       K04501  SMAD4; mothers against decapentaplegic homolog 4
       K04462  EVI1; ecotropic virus integration site 1 protein
       K04496  CTBP; C-terminal binding protein
       K06067  HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
       K08734  MLH1; DNA mismatch repair protein MLH1
       K08735  MSH2; DNA mismatch repair protein MSH2
       K08736  MSH3; DNA mismatch repair protein MSH3
       K08737  MSH6; DNA mismatch repair protein MSH6
       K02159  BAX; apoptosis regulator BAX
       K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
       K04482  RAD51; DNA repair protein RAD51
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K04726  BID; BH3 interacting domain death agonist
       K08738  CYC; cytochrome c
       K03871  VHL; von Hippel-Lindau disease tumor supressor
       K03872  TCEB1; transcription elongation factor B, polypeptide 1
       K03873  TCEB2; transcription elongation factor B, polypeptide 2
       K03868  RBX1, ROC1; RING-box protein 1
       K03870  CUL2; cullin 2
       K09592  EGLN, HPH; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
       K01679  E4.2.1.2B, fumC; fumarate hydratase, class II [EC:4.2.1.2]
       K08268  HIF1A; hypoxia-inducible factor 1 alpha
       K09095  HIF2A, EPAS1; hypoxia-inducible factor 2 alpha
       K09097  ARNT; aryl hydrocarbon receptor nuclear translocator
       K15589  ARNT2; aryl hydrocarbon receptor nuclear translocator 2
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K07299  SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
       K11988  SHH; sonic hedgehog
       K06225  PTCH1; patched 1
       K06226  SMO; smoothened
       K06227  COS2; costal 2
       K06228  FU; fused [EC:2.7.11.1]
       K06229  SUFU; suppressor of fused
       K16797  GLI1; zinc finger protein GLI1
       K16798  GLI2; zinc finger protein GLI2
       K06230  GLI3; zinc finger protein GLI3
       K04662  BMP2_4; bone morphogenetic protein 2/4
       K06231  HHIP; hedgehog interacting protein
       K11101  PTCH2; patched 2
       K08557  NR3C4, AR; androgen receptor
       K04079  htpG, HSP90A; molecular chaperone HtpG
       K09487  HSP90B, TRA1; heat shock protein 90kDa beta
       K01351  KLK3; semenogelase [EC:3.4.21.77]
     05202 Transcriptional misregulation in cancers [PATH:ko05202]
       K08367  RUNX1, AML1; runt-related transcription factor 1
       K05090  CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K10789  MPO; myeloperoxidase [EC:1.11.2.2]
       K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
       K04736  IL3; interleukin 3
       K10053  RUNX1T1, CBFA2T1; runt-related transcription factor 1; translocated to, 1
       K06067  HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
       K11644  SIN3A; paired amphipathic helix protein Sin3a
       K04650  NCOR1, N-CoR; nuclear receptor co-repressor 1
       K09055  CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha
       K09438  SPI1; transcription factor PU.1
       K04391  CD14; CD14 antigen
       K06461  ITGAM; integrin alpha M
       K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
       K10056  JUP; junction plakoglobin
       K10054  PML, TRIM19; probable transcription factor PML
       K08527  NR1B1, RARA; retinoic acid receptor alpha
       K10051  CEBPE; CCAAT/enhancer binding protein (C/EBP), epsilon
       K02162  BCL2A1; hematopoietic BCL2-related protein A1
       K10055  ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
       K04377  MYC; Myc proto-oncogene protein
       K09063  TCF3, E2A; transcription factor E2-alpha
       K09355  PBX1; pre-B-cell leukemia transcription factor 1
       K01558  WNT16; wingless-type MMTV integration site family, member 16
       K03211  ETV6_7, yan; ETS translocation variant 6/7
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K01327  ELANE; leukocyte elastase [EC:3.4.21.37]
       K01353  GZMB; granzyme B [EC:3.4.21.79]
       K09186  MLL1; histone-lysine N-methyltransferase MLL1 [EC:2.1.1.43]
       K15184  AFF1; AF4/FMR2 family member 1
       K02211  CDK9; cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23]
       K15188  CCNT; cyclin T
       K15187  MLLT1_3, ENL, AF9; YEATS domain-containing protein 1/3
       K11427  DOT1L, DOT1; histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
       K15612  LMO2; rhombotin-2
       K15610  PBX3; pre-B-cell leukemia transcription factor 3
       K09278  RUNX2, AML3; runt-related transcription factor 2
       K04676  SMAD1; mothers against decapentaplegic homolog 1
       K15605  KLF3; krueppel-like factor 3
       K04454  MEF2C; MADS-box transcription enhancer factor 2C
       K11449  JMJD1C; jumonji domain-containing protein 1C [EC:1.14.11.-]
       K09283  HMGA2; high mobility group AT-hook protein 2
       K11447  UTX, UTY; histone demethylase [EC:1.14.11.-]
       K11313  SUPT3H, SPT3; transcription initiation protein SPT3
       K06532  PROM1; prominin 1
       K05092  FLT3, FLK2; fms-related tyrosine kinase 3 [EC:2.7.10.1]
       K08854  BMP2K, BIKE; BMP2 inducible kinase [EC:2.7.11.1]
       K05087  IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K08821  CDK14, PFTK1; cyclin-dependent kinase 14 [EC:2.7.11.22]
       K15613  MEIS1; homeobox protein Meis1
       K15614  SIX1; homeobox protein SIX1
       K15615  SIX4; homeobox protein SIX4
       K15616  EYA1; eyes absent homolog 1 [EC:3.1.3.48]
       K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
       K00069  HPGD; 15-hydroxyprostaglandin dehydrogenase (NAD) [EC:1.1.1.141]
       K05199  GRIA3; glutamate receptor 3
       K00717  FUT8; glycoprotein 6-alpha-L-fucosyltransferase [EC:2.4.1.68]
       K15607  TLX3, HOX11L2; T-cell leukemia homeobox protein 3
       K09340  TLX1, HOX11; T-cell leukemia homeobox protein 1
       K04182  CCR7; C-C chemokine receptor type 7
       K15617  LDB1; LIM domain-binding protein 1
       K15604  LYL1; protein lyl-1
       K08024  HHEX, HEX, PRH; homeobox protein HEX
       K06056  PTCRA; pre T-cell antigen receptor alpha
       K09254  REL; c-Rel proto-oncogene protein
       K03172  TRAF1; TNF receptor-associated factor 1
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K05413  CD86; CD86 antigen
       K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
       K15618  BCL6; B-cell lymphoma 6 protein
       K06856  IGH; immunoglobulin heavy chain
       K09035  CMAF, MAF; transcription factor Maf
       K10151  CCND2; cyclin D2
       K06590  ITGB7; integrin beta 7
       K11424  WHSC1, MMSET, NSD2; histone-lysine N-methyltransferase NSD2 [EC:2.1.1.43]
       K11253  H3; histone H3
       K09383  PAX5; paired box protein 5
       K09293  PAX8; paired box protein 8
       K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
       K08524  NR2B1, RXRA; retinoid X receptor alpha
       K08525  NR2B2, RXRB; retinoid X receptor beta
       K08526  NR2B3, RXRG; retinoid X receptor gamma
       K13105  PRCC; proline-rich protein PRCC
       K09105  TFE3; transcription factor E3
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K09633  TMPRSS2; transmembrane protease, serine 2
       K09435  ERG; transcriptional regulator ERG
       K01348  PLAU; urokinase plasminogen activator [EC:3.4.21.73]
       K01343  PLAT; tissue plasminogen activator [EC:3.4.21.68]
       K01394  MMP3; matrix metalloproteinase-3 (stromelysin 1, progelatinase) [EC:3.4.24.17]
       K01403  MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
       K15619  SPINT1; Kunitz-type protease inhibitor 1
       K04387  IL1R2; interleukin 1 receptor type II
       K09431  ETV1; ets translocation variant 1
       K15592  ETV4; ets translocation variant 4
       K15593  ETV5; ets translocation variant 5
       K15379  SLC45A3; solute carrier family 45, member 3
       K04376  ELK4, SAP1; ETS domain-containing protein Elk-4
       K12823  DDX5, DBP2; ATP-dependent RNA helicase DDX5/DBP2 [EC:3.6.4.13]
       K09109  NMYC, MYCN; N-myc proto-oncogene protein
       K04453  MAX; Max protein
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
       K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
       K04451  TP53, P53; tumor protein p53
       K11459  PCGF4, BMI1; polycomb group RING finger protein 4
       K04684  SP1; transcription factor Sp1
       K10500  ZBTB17, MIZ1; zinc finger and BTB domain-containing protein 17
       K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
       K02583  NGFR; nerve growth factor receptor (TNFR superfamily member 16)
       K14970  MEN1, MNN1; menin
       K13209  EWSR1; RNA-binding protein EWS
       K09436  FLI1; friend leukemia integration 1 transcription factor
       K05459  IGF1; insulin-like growth factor 1
       K17693  ID2; DNA-binding protein inhibitor ID2
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K10138  IGFBP3; insulin-like growth factor-binding protein 3
       K09437  FEV; ETS oncogene family protein FEV
       K09053  ATF1; activating transcription factor 1
       K15589  ARNT2; aryl hydrocarbon receptor nuclear translocator 2
       K04728  ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
       K15620  GOLPH3, GPP34; golgi phosphoprotein 3
       K09234  WT1; Wilms tumor protein 1
       K04359  PDGFA; platelet-derived growth factor subunit A
       K05069  IL2RB; interleukin 2 receptor beta
       K15621  BAIAP3; BAI1-associated protein 3
       K06571  TSPAN7, TM4SF2, MXS1; tetraspanin-7
       K15622  MLF1; myeloid leukemia factor 1
       K08559  NR4A3, NOR1; nuclear receptor subfamily 4 group A member 3
       K14651  TAF15; transcription initiation factor TFIID subunit 15
       K13098  TLS, FUS; RNA-binding protein FUS
       K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
       K10048  CEBPB; CCAAT/enhancer binding protein (C/EBP), beta
       K05405  IL6; interleukin 6
       K14242  NFKBIZ; NF-kappa-B inhibitor zeta
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K10030  IL8, CXCL8; interleukin 8
       K07201  FOXO1; forkhead box protein O1
       K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
       K15623  SS18, SSXT, SYT; protein SSXT
       K15624  SSX1; protein SSX1
       K15625  SSX2; protein SSX2
       K15626  NUPR1, COM1; nuclear protein, 1
       K15627  ASPSCR1, ASPL; tether containing UBX domain for GLUT4
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
     05206 MicroRNAs in cancer [PATH:ko05206]
     05205 Proteoglycans in cancer [PATH:ko05205]
     05204 Chemical carcinogenesis [PATH:ko05204]
     05203 Viral carcinogenesis [PATH:ko05203]
     05210 Colorectal cancer [PATH:ko05210]
     05212 Pancreatic cancer [PATH:ko05212]
       K07827  KRAS, KRAS2; GTPase KRas
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K05729  ARHGEF6, PIXA; Rho guanine nucleotide exchange factor 6
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K02158  BAD; BCL2-antagonist of cell death
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K08732  RALGDS; ral guanine nucleotide dissociation stimulator
       K07834  RALA; Ras-related protein Ral-A
       K07835  RALB; Ras-related protein Ral-B
       K08773  RALBP1; RalA-binding protein 1
       K04393  CDC42; cell division control protein 42
       K08774  TGFA; transforming growth factor, alpha
       K04357  EGF; epidermal growth factor
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K04692  STAT3; signal transducer and activator of transcription 3
       K11220  STAT1; signal transducer and activator of transcription 1
       K05448  VEGFA; vascular endothelial growth factor A
       K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K04503  CCND1; cyclin D1
       K06618  RB1; retinoblastoma-associated protein
       K17454  E2F1; transcription factor E2F1
       K09389  E2F2; transcription factor E2F2
       K06620  E2F3; transcription factor E2F3
       K04451  TP53, P53; tumor protein p53
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
       K04501  SMAD4; mothers against decapentaplegic homolog 4
       K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
       K04482  RAD51; DNA repair protein RAD51
     05214 Glioma [PATH:ko05214]
     05216 Thyroid cancer [PATH:ko05216]
     05221 Acute myeloid leukemia [PATH:ko05221]
     05220 Chronic myeloid leukemia [PATH:ko05220]
       K08878  BCR1, BCR; breakpoint cluster region protein [EC:2.7.11.1]
       K06619  ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
       K04438  CRK, CRKII; proto-oncogene C-crk
       K04707  CBL; E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K02158  BAD; BCL2-antagonist of cell death
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
       K04451  TP53, P53; tumor protein p53
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K04364  GRB2; growth factor receptor-binding protein 2
       K08091  GAB2; growth factor receptor bound protein 2-associated protein 2
       K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K06279  SHC1; SHC- transforming protein 1
       K17447  SHC2; SHC- transforming protein 2
       K17448  SHC3; SHC- transforming protein 3
       K17449  SHC4; SHC- transforming protein 4
       K04377  MYC; Myc proto-oncogene protein
       K11223  STAT5A; signal transducer and activator of transcription 5A
       K11224  STAT5B; signal transducer and activator of transcription 5B
       K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K04503  CCND1; cyclin D1
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K06618  RB1; retinoblastoma-associated protein
       K17454  E2F1; transcription factor E2F1
       K09389  E2F2; transcription factor E2F2
       K06620  E2F3; transcription factor E2F3
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K04501  SMAD4; mothers against decapentaplegic homolog 4
       K04462  EVI1; ecotropic virus integration site 1 protein
       K08367  RUNX1, AML1; runt-related transcription factor 1
       K04496  CTBP; C-terminal binding protein
       K06067  HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
     05217 Basal cell carcinoma [PATH:ko05217]
     05218 Melanoma [PATH:ko05218]
     05211 Renal cell carcinoma [PATH:ko05211]
     05219 Bladder cancer [PATH:ko05219]
     05215 Prostate cancer [PATH:ko05215]
     05213 Endometrial cancer [PATH:ko05213]
     05222 Small cell lung cancer [PATH:ko05222]
       K01522  FHIT; bis(5'-adenosyl)-triphosphatase [EC:3.6.1.29]
       K08528  NR1B2, RARB; retinoic acid receptor beta
       K08524  NR2B1, RXRA; retinoid X receptor alpha
       K08525  NR2B2, RXRB; retinoid X receptor beta
       K08526  NR2B3, RXRG; retinoid X receptor gamma
       K04451  TP53, P53; tumor protein p53
       K02161  BCL2; apoptosis regulator BCL-2
       K08738  CYC; cytochrome c
       K02084  APAF1; apoptotic protease-activating factor
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K04377  MYC; Myc proto-oncogene protein
       K04453  MAX; Max protein
       K16063  PIAS2; E3 SUMO-protein ligase PIAS2 [EC:6.3.2.-]
       K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K04503  CCND1; cyclin D1
       K02219  CKS1; cyclin-dependent kinase regulatory subunit CKS1
       K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
       K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
       K06626  CCNE; cyclin E
       K06618  RB1; retinoblastoma-associated protein
       K17454  E2F1; transcription factor E2F1
       K09389  E2F2; transcription factor E2F2
       K06620  E2F3; transcription factor E2F3
       K06237  COL4A; collagen, type IV, alpha
       K05637  LAMA1_2; laminin, alpha 1/2
       K06240  LAMA3_5; laminin, alpha 3/5
       K06241  LAMA4; laminin, alpha 4
       K05636  LAMB1; laminin, beta 1
       K06243  LAMB2; laminin, beta 2
       K06244  LAMB3; laminin, beta 3
       K06245  LAMB4; laminin, beta 4
       K05635  LAMC1; laminin, gamma 1
       K06246  LAMC2; laminin, gamma 2
       K06247  LAMC3; laminin, gamma 3
       K05717  FN1; fibronectin 1
       K06481  ITGA2; integrin alpha 2
       K06476  ITGA2B; integrin alpha 2B
       K06482  ITGA3; integrin alpha 3
       K06485  ITGA6; integrin alpha 6
       K06487  ITGAV; integrin alpha V
       K05719  ITGB1; integrin beta 1
       K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K16060  BIRC2_3; baculoviral IAP repeat-containing protein 2/3
       K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
       K16061  BIRC7_8; baculoviral IAP repeat-containing protein 7/8
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K03172  TRAF1; TNF receptor-associated factor 1
       K03173  TRAF2; TNF receptor-associated factor 2
       K03174  TRAF3; TNF receptor-associated factor 3
       K09848  TRAF4; TNF receptor-associated factor 4
       K09849  TRAF5; TNF receptor-associated factor 5
       K03175  TRAF6; TNF receptor-associated factor 6
       K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
       K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
     05223 Non-small cell lung cancer [PATH:ko05223]
 
   Immune diseases
 
   Neurodegenerative diseases
     05010 Alzheimer's disease [PATH:ko05010]
     05012 Parkinson's disease [PATH:ko05012]
     05014 Amyotrophic lateral sclerosis (ALS) [PATH:ko05014]
       K04451  TP53, P53; tumor protein p53
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K01370  CASP1; caspase 1 [EC:3.4.22.36]
       K04726  BID; BH3 interacting domain death agonist
       K02161  BCL2; apoptosis regulator BCL-2
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K02159  BAX; apoptosis regulator BAX
       K02158  BAD; BCL2-antagonist of cell death
       K02084  APAF1; apoptotic protease-activating factor
       K08738  CYC; cytochrome c
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K04565  SOD1; superoxide dismutase, Cu-Zn family [EC:1.15.1.1]
       K11518  TOM40; mitochondrial import receptor subunit TOM40
       K11519  DERL1; Derlin-1
       K04741  CASP12; caspase 12 [EC:3.4.22.-]
       K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K03158  TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
       K05141  TNFRSF1B, TNFR2; tumor necrosis factor receptor superfamily member 1B
       K02308  DAXX; death-associated protein 6
       K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
       K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K13240  NOS1; nitric-oxide synthase, brain [EC:1.14.13.39]
       K04569  CCS; copper chaperone for superoxide dismutase
       K03781  katE, CAT, catB, srpA; catalase [EC:1.11.1.6]
       K07607  PRPH; peripherin
       K04572  NEFL, NF-L; neurofilament light polypeptide
       K04573  NEF3, NF-M; neurofilament medium polypeptide (neurofilament 3)
       K04574  NEFH, NF-H; neurofilament heavy polypeptide
       K04575  ALS2; amyotrophic lateral sclerosis 2 protein
       K07887  RAB5A; Ras-related protein Rab-5A
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K05613  SLC1A2, EAAT2; solute carrier family 1 (glial high affinity glutamate transporter), member 2
       K05197  GRIA1; glutamate receptor 1
       K05198  GRIA2; glutamate receptor 2
       K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
       K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
       K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
       K05211  GRIN2C; glutamate receptor ionotropic, NMDA 2C
       K05212  GRIN2D; glutamate receptor ionotropic, NMDA 2D
     05016 Huntington's disease [PATH:ko05016]
     05020 Prion diseases [PATH:ko05020]
 
   Substance dependence
 
   Cardiovascular diseases
 
   Endocrine and metabolic diseases
 
   Infectious diseases
     05110 Vibrio cholerae infection [PATH:ko05110]
     05111 Vibrio cholerae pathogenic cycle [PATH:ko05111]
     05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
     05130 Pathogenic Escherichia coli infection [PATH:ko05130]
     05132 Salmonella infection [PATH:ko05132]
     05131 Shigellosis [PATH:ko05131]
     05133 Pertussis [PATH:ko05133]
     05134 Legionellosis [PATH:ko05134]
     05150 Staphylococcus aureus infection [PATH:ko05150]
     05152 Tuberculosis [PATH:ko05152]
     05100 Bacterial invasion of epithelial cells [PATH:ko05100]
     05166 HTLV-I infection [PATH:ko05166]
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K07299  SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
       K06724  NRP1; neuropilin 1
       K06527  VCAM1; vascular cell adhesion molecule 1
       K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
       K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
       K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
       K06490  ICAM1; intercellular adhesion molecule 1
       K05718  ITGAL; integrin alpha L
       K06464  ITGB2; integrin beta 2
       K06271  TLN; talin
       K04377  MYC; Myc proto-oncogene protein
       K08874  TRRAP; transformation/transcription domain-associated protein
       K11304  TIP60, KAT5, ESA1; histone acetyltransferase HTATIP [EC:2.3.1.48]
       K10151  CCND2; cyclin D2
       K15304  RANBP3; Ran-binding protein 3
       K07936  RAN; GTP-binding nuclear protein Ran
       K14290  XPO1, CRM1; exportin-1
       K06751  MHC1; major histocompatibility complex, class I
       K08057  CALR; calreticulin
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
       K17332  NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2
       K17333  NFATC3, NFAT4; nuclear factor of activated T-cells, cytoplasmic 3
       K17334  NFATC4, NFAT3; nuclear factor of activated T-cells, cytoplasmic 4
       K08054  CANX; calnexin
       K05069  IL2RB; interleukin 2 receptor beta
       K05070  IL2RG; interleukin 2 receptor gamma
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K11218  JAK3; Janus kinase 3 [EC:2.7.10.2]
       K11223  STAT5A; signal transducer and activator of transcription 5A
       K11224  STAT5B; signal transducer and activator of transcription 5B
       K00787  FDPS; farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K07829  RRAS; Ras-related protein R-Ras
       K07830  RRAS2, TC21; Ras-related protein R-Ras2
       K07831  MRAS; Ras-related protein M-Ras
       K05862  VDAC1; voltage-dependent anion channel protein 1
       K05863  SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31
       K15040  VDAC2; voltage-dependent anion channel protein 2
       K15041  VDAC3; voltage-dependent anion channel protein 3
       K05770  BZRP; benzodiazapine receptor
       K15305  VAC14, TAX1BP2; vacuole morphology and inheritance protein 14
       K15306  RANBP1; Ran-binding protein 1
       K06679  MAD1; mitotic spindle assembly checkpoint protein MAD1
       K02537  MAD2; mitotic spindle assembly checkpoint protein MAD2
       K06637  BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [EC:2.7.11.1]
       K02180  BUB3; cell cycle arrest protein BUB3
       K03363  CDC20; cell division cycle 20, cofactor of APC complex
       K03348  APC1; anaphase-promoting complex subunit 1
       K03349  APC2; anaphase-promoting complex subunit 2
       K03350  APC3, CDC27; anaphase-promoting complex subunit 3
       K03351  APC4; anaphase-promoting complex subunit 4
       K03352  APC5; anaphase-promoting complex subunit 5
       K03353  APC6, CDC16; anaphase-promoting complex subunit 6
       K03354  APC7; anaphase-promoting complex subunit 7
       K03355  APC8, CDC23; anaphase-promoting complex subunit 8
       K03356  APC9; anaphase-promoting complex subunit 9
       K03357  APC10, DOC1; anaphase-promoting complex subunit 10
       K03358  APC11; anaphase-promoting complex subunit 11
       K03359  APC12, CDC26; anaphase-promoting complex subunit 12
       K12416  SWM1, APC13; anaphase-promoting complex subunit SWM1
       K06635  PTTG; securin
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K04802  PCNA; proliferating cell nuclear antigen
       K02327  POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
       K02328  POLD2; DNA polymerase delta subunit 2
       K03504  POLD3; DNA polymerase delta subunit 3
       K03505  POLD4; DNA polymerase delta subunit 4
       K02324  POLE1; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
       K02325  POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
       K02326  POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
       K03506  POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
       K04503  CCND1; cyclin D1
       K10152  CCND3; cyclin D3
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K06618  RB1; retinoblastoma-associated protein
       K17454  E2F1; transcription factor E2F1
       K09389  E2F2; transcription factor E2F2
       K06620  E2F3; transcription factor E2F3
       K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
       K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
       K03209  WNT1; wingless-type MMTV integration site family, member 1
       K00182  WNT2; wingless-type MMTV integration site family, member 2
       K00312  WNT3; wingless-type MMTV integration site family, member 3
       K00408  WNT4; wingless-type MMTV integration site family, member 4
       K00444  WNT5; wingless-type MMTV integration site family, member 5
       K00445  WNT6; wingless-type MMTV integration site family, member 6
       K00572  WNT7; wingless-type MMTV integration site family, member 7
       K00714  WNT8; wingless-type MMTV integration site family, member 8
       K01064  WNT9; wingless-type MMTV integration site family, member 9
       K01357  WNT10; wingless-type MMTV integration site family, member 10
       K01384  WNT11; wingless-type MMTV integration site family, member 11
       K01558  WNT16; wingless-type MMTV integration site family, member 16
       K02432  FZD1_7, fz; frizzled 1/7
       K02235  FZD2; frizzled 2
       K02329  FZD3; frizzled 3
       K02354  FZD4, fz4; frizzled 4
       K02375  FZD5_8, fz2; frizzled 5/8
       K02376  FZD6; frizzled 6
       K02842  FZD9_10; frizzled 9/10
       K04690  FZDN, fz3; frizzled
       K02353  DVL; segment polarity protein dishevelled
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K02105  CTNNB1; catenin beta 1
       K02085  APC; adenomatosis polyposis coli protein
       K12076  DLG1; disks large protein 1
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K04363  PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K03158  TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
       K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
       K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
       K04448  JUN; transcription factor AP-1
       K15307  GPS2; G protein pathway suppressor 2
       K04386  IL1R1; interleukin 1 receptor type I
       K04387  IL1R2; interleukin 1 receptor type II
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K03159  TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3
       K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
       K05151  TNFRSF13C, BAFFR; tumor necrosis factor receptor superfamily member 13C
       K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
       K09253  RELB; transcription factor RelB
       K04469  NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
       K05429  IL2; interleukin 2
       K05068  IL2RA, CD25; interleukin 2 receptor alpha
       K05433  IL15; interleukin 15
       K05074  IL15RA; interleukin 15 receptor alpha
       K05405  IL6; interleukin 6
       K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
       K05468  LTA, TNFB; lymphotoxin alpha (TNF superfamily, member 1)
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
       K15308  TTP; tristetraprolin
       K08065  NFYB; nuclear transcription Y subunit beta
       K06752  MHC2; major histocompatibility complex, class II
       K04378  SRF; serum response factor
       K04376  ELK4, SAP1; ETS domain-containing protein Elk-4
       K04375  ELK1; ETS domain-containing protein Elk-1
       K09438  SPI1; transcription factor PU.1
       K02678  ETS, pnt; c-ets proto-oncogene protein
       K03120  TBP, tbp; transcription initiation factor TFIID TATA-box-binding protein
       K04379  FOS; proto-oncogene protein c-fos
       K09203  EGR1; early growth response protein 1
       K12496  EGR2; early growth response protein 2
       K04502  FOSL1; fos-like antigen 1
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K09052  CREM; cAMP response element modulator
       K09053  ATF1; activating transcription factor 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K09032  ATF3, LRF1; activating transcription factor 3
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09027  XBP1; X box-binding protein 1
       K15309  CRTC1, TORC1; CREB-regulated transcription coactivator 1
       K16333  CRTC2, TORC2; CREB-regulated transcription coactivator 2
       K16334  CRTC3, TORC3; CREB-regulated transcription coactivator 3
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K06062  PCAF, KAT2, GCN5; histone acetyltransferase [EC:2.3.1.48]
       K09063  TCF3, E2A; transcription factor E2-alpha
       K02330  POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
       K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
       K05856  LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
       K11126  TERT, EST2; telomerase reverse transcriptase [EC:2.7.7.49]
       K09420  MYB; myb proto-oncogene protein
       K09421  MYBL; myb-related protein
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
       K04501  SMAD4; mothers against decapentaplegic homolog 4
       K04728  ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
       K06640  ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
       K02216  CHK1; serine/threonine-protein kinase Chk1 [EC:2.7.11.1]
       K06641  CHK2; serine/threonine-protein kinase Chk2 [EC:2.7.11.1]
       K04451  TP53, P53; tumor protein p53
       K02159  BAX; apoptosis regulator BAX
       K15310  TP53INP1; tumor protein p53-inducible nuclear protein 1
       K09341  MSX; homeobox protein MSX
     05162 Measles [PATH:ko05162]
     05164 Influenza A [PATH:ko05164]
     05161 Hepatitis B [PATH:ko05161]
     05160 Hepatitis C [PATH:ko05160]
     05168 Herpes simplex infection [PATH:ko05168]
     05169 Epstein-Barr virus infection [PATH:ko05169]
     05146 Amoebiasis [PATH:ko05146]
     05144 Malaria [PATH:ko05144]
     05145 Toxoplasmosis [PATH:ko05145]
       K04687  IFNG; interferon gamma
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
       K11220  STAT1; signal transducer and activator of transcription 1
       K08060  CIITA; class II, major histocompatibility complex, transactivator
       K06752  MHC2; major histocompatibility complex, class II
       K14139  IRGM, LRG47; immunity-related GTPase family M protein [EC:3.6.5.-]
       K14140  IGTP; interferon gamma induced GTPase
       K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
       K04694  SOCS1, JAB; suppressor of cytokine signaling 1
       K14141  PFNL; profilin-like protein
       K14142  TLR11; toll-like receptor 11
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K04730  IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K03175  TRAF6; TNF receptor-associated factor 6
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K04403  MAP3K7IP1, TAB1; TAK1-binding protein 1
       K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
       K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02581  NFKBIB; NF-kappa-B inhibitor beta
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K05406  IL12A; interleukin 12A
       K05425  IL12B; interleukin 12B
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K02161  BCL2; apoptosis regulator BCL-2
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K16060  BIRC2_3; baculoviral IAP repeat-containing protein 2/3
       K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
       K16061  BIRC7_8; baculoviral IAP repeat-containing protein 7/8
       K05400  LY96, MD-2; lymphocyte antigen 96
       K10160  TLR4; toll-like receptor 4
       K03283  HSPA1_8; heat shock 70kDa protein 1/8
       K10159  TLR2; toll-like receptor 2
       K05637  LAMA1_2; laminin, alpha 1/2
       K06240  LAMA3_5; laminin, alpha 3/5
       K06241  LAMA4; laminin, alpha 4
       K05636  LAMB1; laminin, beta 1
       K06243  LAMB2; laminin, beta 2
       K06244  LAMB3; laminin, beta 3
       K06245  LAMB4; laminin, beta 4
       K05635  LAMC1; laminin, gamma 1
       K06246  LAMC2; laminin, gamma 2
       K06247  LAMC3; laminin, gamma 3
       K06485  ITGA6; integrin alpha 6
       K05719  ITGB1; integrin beta 1
       K14143  SAG; major surface antigen
       K14144  MIC3; microneme protein
       K13412  CPK; calcium-dependent protein kinase [EC:2.7.11.1]
       K13845  AMA-1; apical merozoite antigen 1
       K14145  RON2; rhoptry neck protein 2
       K14146  RON4; rhoptry neck protein 4
       K12473  LDLR; low-density lipoprotein receptor
       K14147  GRA7; dense granule protein 7
       K14148  ROP2; rhoptry protein 2
       K14149  GRA3; dense granule protein 3
       K14150  GRA5; dense granule protein 5
       K03158  TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K08738  CYC; cytochrome c
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K02158  BAD; BCL2-antagonist of cell death
       K03161  TNFSF5, CD40L; tumor necrosis factor ligand superfamily member 5
       K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
       K09565  PPIF; peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]
       K04180  CCR5; C-C chemokine receptor type 5
       K00461  ALOX5; arachidonate 5-lipoxygenase [EC:1.13.11.34]
       K14151  ROP16; rhoptry protein 16
       K05443  IL10, CSIF; interleukin 10
       K05134  IL10RA; interleukin 10 receptor alpha
       K05135  IL10RB; interleukin 10 receptor beta
       K11219  TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
       K04692  STAT3; signal transducer and activator of transcription 3
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
     05140 Leishmaniasis [PATH:ko05140]
     05142 Chagas disease (American trypanosomiasis) [PATH:ko05142]
     05143 African trypanosomiasis [PATH:ko05143]
 
   Drug resistance

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Last updated: October 21, 2014