 Metabolism
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Genetic Information Processing
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Environmental Information Processing
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 Cellular Processes
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Transport and catabolism
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04144 Endocytosis [PATH:ko04144]
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 K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K04674 TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04679 MADHIP, SARA; MAD, mothers against decapentaplegic interacting protein
K10054 PML, TRIM19; probable transcription factor PML
K04500 SMAD2_3; mothers against decapentaplegic homolog 2/3
K06503 TFRC, CD71; transferrin receptor
K04361 EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K05096 FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
K05098 KDR, VEGFR2; kinase insert domain protein receptor [EC:2.7.10.1]
K04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094 FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
K05095 FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
K05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K05099 MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K03176 NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K05084 ERBB3, HER3; receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1]
K05085 ERBB4, HER4; receptor tyrosine-protein kinase erbB-4 [EC:2.7.10.1]
K05091 KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
K05090 CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K04357 EGF; epidermal growth factor
K01528 DNM; dynamin GTPase [EC:3.6.5.5]
K07941 ARF6; ADP-ribosylation factor 6
K00889 E2.7.1.68, PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
K13712 PIP5KL1; phosphatidylinositol-4-phosphate 5-kinase-like protein 1 [EC:2.7.1.68]
K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
K04644 CLTA, LCA; clathrin light chain A
K04645 CLTB, LCB; clathrin light chain B
K04646 CLTC; clathrin heavy chain
K11824 AP2A; AP-2 complex subunit alpha
K11825 AP2B1; AP-2 complex subunit beta-1
K11826 AP2M1; AP-2 complex subunit mu-1
K11827 AP2S1; AP-2 complex subunit sigma-1
K12469 EHD2; EH domain-containing protein 2
K04707 CBL; E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
K10591 NEDD4, RSP5; E3 ubiquitin-protein ligase NEDD4 [EC:6.3.2.19]
K13305 NEDD4L; E3 ubiquitin-protein ligase NEDD4-like [EC:6.3.2.19]
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
K03175 TRAF6; TNF receptor-associated factor 6
K11981 RNF41, NRDP1; E3 ubiquitin-protein ligase NRDP1 [EC:6.3.2.19]
K05632 AIP4, ITCH; atrophin-1 interacting protein 4 [EC:6.3.2.19]
K04678 SMURF; E3 ubiquitin ligase SMURF1/2 [EC:6.3.2.19]
K05633 AIP5, WWP1; atrophin-1 interacting protein 5 (WW domain containing E3 ubiquitin protein ligase 1) [EC:6.3.2.19]
K12470 SH3KBP1, CIN85; SH3 domain-containing kinase-binding protein 1
K11247 SH3GL; endophilin-A
K11248 SH3GLB; endophilin-B
K12471 EPN; epsin
K12472 EPS15; epidermal growth factor receptor substrate 15
K12473 LDLR; low-density lipoprotein receptor
K12474 LDLRAP1, ARH; low density lipoprotein receptor adapter protein 1
K12475 DAB2; disabled homolog 2
K04180 CCR5; C-C chemokine receptor type 5
K04175 IL8RA, CXCR1; interleukin 8 receptor alpha
K05050 IL8RB, CXCR2; interleukin 8 receptor beta
K04189 CXCR4; C-X-C chemokine receptor type 4
K03914 F2R, PAR1; coagulation factor II (thrombin) receptor
K04141 ADRB1; adrenergic receptor beta-1
K04142 ADRB2; adrenergic receptor beta-2
K04143 ADRB3; adrenergic receptor beta-3
K00909 GRK1_7; rhodopsin kinase [EC:2.7.11.14]
K00910 ADRBK, GRK; beta-adrenergic-receptor kinase [EC:2.7.11.15]
K08291 GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]
K04439 ARRB; beta-arrestin
K04677 SMAD6_7; mothers against decapentaplegic homolog 6/7
K13649 FOLR; folate receptor
K06278 CAV1; caveolin 1
K12958 CAV2; caveolin 2
K12959 CAV3; caveolin 3
K06751 MHC1; major histocompatibility complex, class I
K05068 IL2RA, CD25; interleukin 2 receptor alpha
K05069 IL2RB; interleukin 2 receptor beta
K05070 IL2RG; interleukin 2 receptor gamma
K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
K02833 HRAS; GTPase HRas
K04513 RHOA; Ras homolog gene family, member A
K03283 HSPA1_8; heat shock 70kDa protein 1/8
K09526 DNAJC6; DnaJ homolog subfamily C member 6
K11839 USP8, UBP5; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.1.2.15]
K11866 STAMBP, AMSH; STAM-binding protein [EC:3.1.2.15]
K07897 RAB7A; Ras-related protein Rab-7A
K12182 HGS, HRS, VPS27; hepatocyte growth factor-regulated tyrosine kinase substrate
K04705 STAM; signal transducing adaptor molecule
K12183 TSG101, STP22, VPS23; ESCRT-I complex subunit TSG101
K12186 FAM125; ESCRT-I complex subunit MVB12
K12187 MVB12; ESCRT-I complex subunit MVB12
K12184 VPS28; ESCRT-I complex subunit VPS28
K12185 VPS37; ESCRT-I complex subunit VPS37
K12188 SNF8, EAP30; ESCRT-II complex subunit VPS22
K12190 VPS36, EAP45; ESCRT-II complex subunit VPS36
K12189 VPS25, EAP20; ESCRT-II complex subunit VPS25
K12195 CHMP6, VPS20; charged multivesicular body protein 6
K12194 CHMP4, SNF7, VPS32; charged multivesicular body protein 4
K12193 VPS24, CHMP3; charged multivesicular body protein 3
K12191 CHMP2A; charged multivesicular body protein 2A
K12192 CHMP2B; charged multivesicular body protein 2B
K15053 CHMP7; charged multivesicular body protein 7
K12196 VPS4; vacuolar protein-sorting-associated protein 4
K12199 VTA1, LIP5; vacuolar protein sorting-associated protein VTA1
K12197 CHMP1, VPS46, DID2; charged multivesicular body protein 1
K12198 CHMP5, VPS60; charged multivesicular body protein 5
K12200 PDCD6IP, ALIX, RIM20; programmed cell death 6-interacting protein
K12476 EHD3; EH domain-containing protein 3
K12477 EHD4; EH domain-containing protein 4
K12478 EEA1; early endosome antigen 1
K07887 RAB5A; Ras-related protein Rab-5A
K07888 RAB5B; Ras-related protein Rab-5B
K07889 RAB5C; Ras-related protein Rab-5C
K12479 VPS45; vacuolar protein sorting-associated protein 45
K12480 RABEP1; Rab GTPase-binding effector protein 1
K12481 ZFYVE20; rabenosyn-5
K07879 RAB4A, RAB4; Ras-related protein Rab-4A
K12482 RUFY1, RABIP4; RUN and FYVE domain-containing protein 1
K12483 EHD1; EH domain-containing protein 1
K09235 RME1; zinc finger protein RME1
K07904 RAB11A; Ras-related protein Rab-11A
K07905 RAB11B; Ras-related protein Rab-11B
K12484 RAB11FIP1_2_5; Rab11 family-interacting protein 1/2/5
K12485 RAB11FIP3_4; Rab11 family-interacting protein 3/4
K07891 RAB22A; Ras-related protein Rab-22A
K07892 RAB31, RAB22B; Ras-related protein Rab-31
K04237 PARD3; partitioning defective protein 3
K06093 PARD6; partitioning defective protein 6
K06069 APKC; atypical protein kinase C [EC:2.7.11.13]
K04393 CDC42; cell division control protein 42
K12486 SMAP; stromal membrane-associated protein
K05737 GIT1; G protein-coupled receptor kinase interactor 1
K12487 GIT2; G protein-coupled receptor kinase interactor 2
K12488 ASAP; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein
K12489 ACAP; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein
K12490 ARAP; Arf-GAP, Rho-GAP domain, ANK repeat and PH domain-containing protein
K12491 AGAP1_2_3; Arf-GAP, GTPase, ANK repeat and PH domain-containing protein 1/2/3
K12492 ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1
K12493 ARFGAP2_3; ADP-ribosylation factor GTPase-activating protein 2/3
K12494 PSD; PH and SEC7 domain-containing protein
K12495 IQSEC; IQ motif and SEC7 domain-containing protein
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04145 Phagosome [PATH:ko04145]
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04142 Lysosome [PATH:ko04142]
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K02154 ATPeVI, ATP6N1A; V-type H+-transporting ATPase subunit I [EC:3.6.3.14]
K02146 ATPeVAC39, ATP6D; V-type H+-transporting ATPase subunit AC39 [EC:3.6.3.14]
K02144 ATPeV54kD; V-type H+-transporting ATPase 54 kD subunit [EC:3.6.3.14]
K03662 ATPeVS1, ATP6S1; V-type H+-transporting ATPase S1 subunit [EC:3.6.3.14]
K02155 ATPeVPL, ATP6L; V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14]
K03661 ATPeVPF, ATP6F; V-type H+-transporting ATPase 21kDa proteolipid subunit [EC:3.6.3.14]
K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
K01363 CTSB; cathepsin B [EC:3.4.22.1]
K01275 CTSC; cathepsin C [EC:3.4.14.1]
K01379 CTSD; cathepsin D [EC:3.4.23.5]
K01382 CTSE; cathepsin E [EC:3.4.23.34]
K01373 CTSF; cathepsin F [EC:3.4.22.41]
K01319 CTSG; cathepsin G [EC:3.4.21.20]
K01366 CTSH; cathepsin H [EC:3.4.22.16]
K09599 CTSP; cathepsin P [EC:3.4.22.-]
K01371 CTSK; cathepsin K [EC:3.4.22.38]
K01365 CTSL; cathepsin L [EC:3.4.22.15]
K09600 CTSM; cathepsin M [EC:3.4.22.-]
K01374 CTSO; cathepsin O [EC:3.4.22.42]
K01368 CTSS; cathepsin S [EC:3.4.22.27]
K01375 CTSL2, CTSV; cathepsin V [EC:3.4.22.43]
K08569 CTSW; cathepsin W [EC:3.4.22.-]
K08568 CTSZ; cathepsin X [EC:3.4.18.1]
K08565 NAPSA; napsin-A [EC:3.4.23.-]
K01369 LGMN; legumain [EC:3.4.22.34]
K01279 TPP1, CLN2; tripeptidyl-peptidase I [EC:3.4.14.9]
K01189 GLA; alpha-galactosidase [EC:3.2.1.22]
K12309 GLB1, ELNR1; beta-galactosidase [EC:3.2.1.23]
K12316 GAA; lysosomal alpha-glucosidase [EC:3.2.1.20]
K01201 E3.2.1.45, GBA, srfJ; glucosylceramidase [EC:3.2.1.45]
K01217 IDUA; L-iduronidase [EC:3.2.1.76]
K01204 NAGA; alpha-N-acetylgalactosaminidase [EC:3.2.1.49]
K01205 NAGLU; alpha-N-acetylglucosaminidase [EC:3.2.1.50]
K01202 GALC; galactosylceramidase [EC:3.2.1.46]
K01195 E3.2.1.31, GUSB, uidA; beta-glucuronidase [EC:3.2.1.31]
K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
K01192 E3.2.1.25, MANBA, manB; beta-mannosidase [EC:3.2.1.25]
K12311 MAN2B1, LAMAN; lysosomal alpha-mannosidase [EC:3.2.1.24]
K01186 NEU1; sialidase-1 [EC:3.2.1.18]
K01134 ARSA; arylsulfatase A [EC:3.1.6.8]
K01135 ARSB; arylsulfatase B [EC:3.1.6.12]
K12381 ARSG; arylsulfatase G [EC:3.1.6.-]
K01132 GALNS; N-acetylgalactosamine-6-sulfatase [EC:3.1.6.4]
K01137 GNS; N-acetylglucosamine-6-sulfatase [EC:3.1.6.14]
K01136 IDS; iduronate 2-sulfatase [EC:3.1.6.13]
K01565 SGSH; N-sulfoglucosamine sulfohydrolase [EC:3.10.1.1]
K01052 LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [EC:3.1.1.13]
K06129 LYPLA3; lysophospholipase III [EC:3.1.1.5]
K01158 DNASE2; deoxyribonuclease II [EC:3.1.22.1]
K12350 SMPD1, ASM; sphingomyelin phosphodiesterase [EC:3.1.4.12]
K12348 ASAH1; acid ceramidase [EC:3.5.1.23]
K01444 E3.5.1.26; N4-(beta-N-acetylglucosaminyl)-L-asparaginase [EC:3.5.1.26]
K12382 PSAP, SGP1; saposin
K12383 GM2A; ganglioside GM2 activator
K01074 PPT; palmitoyl-protein thioesterase [EC:3.1.2.22]
K06528 LAMP1_2, CD107; lysosomal-associated membrane protein 1/2
K06562 LAMP3; lysosomal-associated membrane protein 3
K06501 CD68; CD68 antigen
K06497 CD63, MLA1; CD63 antigen
K12384 SCARB2, LIMP2, CD36L2; lysosome membrane protein 2
K12385 NPC1; Niemann-Pick C1 protein
K13443 NPC2; Niemann-Pick C2 protein
K12386 CTNS; cystinosin
K12301 SLC17A5; MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5
K12347 SLC11A, NRAMP; natural resistance-associated macrophage protein
K12387 LAPTM; lysosomal-associated transmembrane protein
K05642 ABCA2; ATP-binding cassette, subfamily A (ABC1), member 2
K05656 ABCB9, TAPL; ATP-binding cassette, subfamily B (MDR/TAP), member 9
K06546 CD164, MGC24; CD164 antigen
K12305 ENTPD4, LALP70; ectonucleoside triphosphate diphosphohydrolase 4 [EC:3.6.1.6]
K12388 SORT1; sortilin
K12389 BTS, CLN3; battenin
K12390 CLN5; ceroid-lipofuscinosis neuronal protein 5
K12307 MSFD8, CLN7; MFS transporter, ceroid-lipofuscinosis neuronal protein 7
K10532 HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [EC:2.3.1.78]
K13444 SUMF1, FGE; sulfatase modifying factor 1
K08239 GNPTAB; UDP-N-acetylglucosamine-lysosomal-enzyme [EC:2.7.8.17]
K10087 GNPTG, GNPTAG; N-acetylglucosamine-1-phosphate transferase, gamma subunit
K01125 NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [EC:3.1.4.45]
K06564 IGF2R; insulin-like growth factor 2 receptor
K10089 M6PR; cation-dependent mannose-6-phosphate receptor
K04644 CLTA, LCA; clathrin light chain A
K04645 CLTB, LCB; clathrin light chain B
K04646 CLTC; clathrin heavy chain
K12391 AP1G1; AP-1 complex subunit gamma-1
K12392 AP1B1; AP-1 complex subunit beta-1
K12393 AP1M; AP-1 complex subunit mu
K12394 AP1S1_2; AP-1 complex subunit sigma 1/2
K12395 AP1S3; AP-1 complex subunit sigma-3
K12396 AP3D1; AP-3 complex subunit delta-1
K12397 AP3B; AP-3 complex subunit beta
K12398 AP3M; AP-3 complex subunit mu
K12399 AP3S; AP-3 complex subunit sigma
K12400 AP4E1; AP-4 complex subunit epsilon-1
K12401 AP4B1; AP-4 complex subunit beta-1
K12402 AP4M1; AP-4 complex subunit mu-1
K12403 AP4S1; AP-4 complex subunit sigma-1
K12404 GGA; ADP-ribosylation factor-binding protein GGA
K04992 MCOLN1; mucolipin 1
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04146 Peroxisome [PATH:ko04146]
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04140 Regulation of autophagy [PATH:ko04140]
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Cell motility
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Cell growth and death
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Cell communication
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Organismal Systems
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Immune system
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Endocrine system
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Circulatory system
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Digestive system
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Excretory system
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04962 Vasopressin-regulated water reabsorption [PATH:ko04962]
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04960 Aldosterone-regulated sodium reabsorption [PATH:ko04960]
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04961 Endocrine and other factor-regulated calcium reabsorption [PATH:ko04961]
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K04585 PTHR1; parathyroid hormone receptor 1
K04632 GNAS; guanine nucleotide-binding protein G(s) subunit alpha
K08046 ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08049 ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K04345 PKA; protein kinase A [EC:2.7.11.11]
K08539 NR1I1, VDR; vitamin D3 receptor
K08550 NR3A1, ESR1; estrogen receptor alpha
K04974 TRPV5; transient receptor potential cation channel subfamily V member 5
K14756 KL; klotho [EC:3.2.1.31]
K01528 DNM; dynamin GTPase [EC:3.6.5.5]
K11824 AP2A; AP-2 complex subunit alpha
K11825 AP2B1; AP-2 complex subunit beta-1
K11826 AP2M1; AP-2 complex subunit mu-1
K11827 AP2S1; AP-2 complex subunit sigma-1
K04644 CLTA, LCA; clathrin light chain A
K04645 CLTB, LCB; clathrin light chain B
K04646 CLTC; clathrin heavy chain
K07904 RAB11A; Ras-related protein Rab-11A
K14757 CALB1, CALB; calbindin D28
K01539 ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]
K01540 ATP1B; sodium/potassium-transporting ATPase subunit beta
K01538 FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
K01325 KLK1_2; tissue kallikrein [EC:3.4.21.35]
K03916 BDKRB2; bradykinin receptor B2
K04634 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K02677 CPKC; classical protein kinase C [EC:2.7.11.13]
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04964 Proximal tubule bicarbonate reclamation [PATH:ko04964]
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04966 Collecting duct acid secretion [PATH:ko04966]
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Nervous system
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04724 Glutamatergic synapse [PATH:ko04724]
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04727 GABAergic synapse [PATH:ko04727]
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04725 Cholinergic synapse [PATH:ko04725]
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04728 Dopaminergic synapse [PATH:ko04728]
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04726 Serotonergic synapse [PATH:ko04726]
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04720 Long-term potentiation [PATH:ko04720]
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04730 Long-term depression [PATH:ko04730]
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04723 Retrograde endocannabinoid signaling [PATH:ko04723]
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04721 Synaptic vesicle cycle [PATH:ko04721]
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K15015 SLC32A, VGAT; solute carrier family 32 (vesicular inhibitory amino acid transporter)
K08155 SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
K14636 SLC18A3, VACHT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular acetylcholine transporter), member 3
K12302 SLC17A6_7_8; MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6/7/8
K15290 SYT1; synaptotagmin-1
K13504 VAMP2; vesicle-associated membrane protein 2
K07882 RAB3A; Ras-related protein Rab-3A
K15291 RIMS1, RIM1; regulating synaptic membrane exocytosis protein 1
K04560 STX1A; syntaxin 1A
K08486 STX1B_2_3; syntaxin 1B/2/3
K15292 STXBP1, MUNC18-1; syntaxin-binding protein 1
K15293 UNC13, MUNC13; protein unc-13
K15294 CPLX1_2; complexin-1/2
K15295 CPLX3_4; complexin-3/4
K04344 CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
K04849 CACNA1B; voltage-dependent calcium channel N type alpha-1B
K06027 NSF; vesicle-fusing ATPase [EC:3.6.4.6]
K15296 NAPA, SNAPA, SEC17; alpha-soluble NSF attachment protein
K01528 DNM; dynamin GTPase [EC:3.6.5.5]
K04644 CLTA, LCA; clathrin light chain A
K04645 CLTB, LCB; clathrin light chain B
K04646 CLTC; clathrin heavy chain
K11824 AP2A; AP-2 complex subunit alpha
K11825 AP2B1; AP-2 complex subunit beta-1
K11826 AP2M1; AP-2 complex subunit mu-1
K11827 AP2S1; AP-2 complex subunit sigma-1
K02145 ATPeVA, ATP6A1; V-type H+-transporting ATPase subunit A [EC:3.6.3.14]
K02147 ATPeVB, ATP6B1; V-type H+-transporting ATPase subunit B [EC:3.6.3.14]
K02148 ATPeVC, ATP6C; V-type H+-transporting ATPase subunit C [EC:3.6.3.14]
K02149 ATPeVD, ATP6M; V-type H+-transporting ATPase subunit D [EC:3.6.3.14]
K02150 ATPeVE, ATP6E; V-type H+-transporting ATPase subunit E [EC:3.6.3.14]
K02151 ATPeVF, ATP6S14; V-type H+-transporting ATPase subunit F [EC:3.6.3.14]
K02152 ATPeVG, ATP6G1; V-type H+-transporting ATPase subunit G [EC:3.6.3.14]
K02153 ATPeVH, ATP6H; V-type H+-transporting ATPase subunit H [EC:3.6.3.14]
K02154 ATPeVI, ATP6N1A; V-type H+-transporting ATPase subunit I [EC:3.6.3.14]
K02146 ATPeVAC39, ATP6D; V-type H+-transporting ATPase subunit AC39 [EC:3.6.3.14]
K02144 ATPeV54kD; V-type H+-transporting ATPase 54 kD subunit [EC:3.6.3.14]
K02155 ATPeVPL, ATP6L; V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14]
K03661 ATPeVPF, ATP6F; V-type H+-transporting ATPase 21kDa proteolipid subunit [EC:3.6.3.14]
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04722 Neurotrophin signaling pathway [PATH:ko04722]
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Sensory system
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Development
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Environmental adaptation
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Human Diseases
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Cancers
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Immune diseases
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Neurodegenerative diseases
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05010 Alzheimer's disease [PATH:ko05010]
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05012 Parkinson's disease [PATH:ko05012]
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05014 Amyotrophic lateral sclerosis (ALS) [PATH:ko05014]
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05016 Huntington's disease [PATH:ko05016]
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K04644 CLTA, LCA; clathrin light chain A
K04645 CLTB, LCB; clathrin light chain B
K04646 CLTC; clathrin heavy chain
K04559 HIP1; huntingtin interacting protein 1
K11824 AP2A; AP-2 complex subunit alpha
K11825 AP2B1; AP-2 complex subunit beta-1
K11826 AP2M1; AP-2 complex subunit mu-1
K11827 AP2S1; AP-2 complex subunit sigma-1
K04533 HD; huntingtin
K04638 ESRRBL1, HIPPI; estrogen-related receptor beta like 1
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04604 GRM5; metabotropic glutamate receptor 5
K04634 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05208 GRIN1; glutamate receptor ionotropic, NMDA 1
K05210 GRIN2B; glutamate receptor ionotropic, NMDA 2B
K04958 ITPR1; inositol 1,4,5-triphosphate receptor type 1
K11828 DLG4, PSD95; discs large protein 4
K05625 TGM2; transglutaminase 2 [EC:2.3.2.13]
K09222 REST; RE1-silencing transcription factor
K11644 SIN3A; paired amphipathic helix protein Sin3a
K11829 RCOR1, COREST; REST corepressor 1
K06067 HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K03006 RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
K03010 RPB2, POLR2B; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
K03011 RPB3, POLR2C; DNA-directed RNA polymerase II subunit RPB3
K03012 RPB4, POLR2D; DNA-directed RNA polymerase II subunit RPB4
K03013 RPB5, POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1
K03014 RPB6, POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2
K03015 RPB7, POLR2G; DNA-directed RNA polymerase II subunit RPB7
K03016 RPB8, POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3
K03017 RPB9, POLR2I; DNA-directed RNA polymerase II subunit RPB9
K03007 RPB10, POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5
K03008 RPB11, POLR2J; DNA-directed RNA polymerase II subunit RPB11
K03009 RPB12, POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4
K04355 BDNF; brain-derived neurotrophic factor
K04648 DCTN1; dynactin 1
K10424 DCTN2; dynactin 2
K10426 DCTN4; dynactin 4
K04647 HAP1; huntingtin-associated protein 1
K10408 DNAH; dynein heavy chain, axonemal
K10410 DNALI; dynein light intermediate chain, axonemal
K10409 DNAI1; dynein intermediate chain 1, axonemal
K11143 DNAI2; dynein intermediate chain 2, axonemal
K10411 DNAL1; dynein light chain 1, axonemal
K10412 DNAL4; dynein light chain 4, axonemal
K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K03129 TAF4; transcription initiation factor TFIID subunit 4
K03120 TBP, tbp; transcription initiation factor TFIID TATA-box-binding protein
K04684 SP1; transcription factor Sp1
K05870 CREB1; cyclic AMP-responsive element-binding protein 1
K09048 CREB3; cyclic AMP-responsive element-binding protein 3
K09047 CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
K07202 PGC1; peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
K08530 NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
K11830 TFAM, MTTFA; transcription factor A, mitochondrial
K11831 NRF1; nuclear respiratory factor 1
K04565 SOD1; superoxide dismutase, Cu-Zn family [EC:1.15.1.1]
K04564 SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]
K08769 UCP1, SLC25A7; solute carrier family 25 (mitochondrial uncoupling protein), member 7
K04451 TP53, P53; tumor protein p53
K02159 BAX; apoptosis regulator BAX
K10132 BBC3, PUMA; BCL2-binding component 3
K03942 NDUFV1; NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:1.6.5.3 1.6.99.3]
K03943 NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:1.6.5.3 1.6.99.3]
K03944 NDUFV3; NADH dehydrogenase (ubiquinone) flavoprotein 3 [EC:1.6.5.3 1.6.99.3]
K03945 NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 1 [EC:1.6.5.3 1.6.99.3]
K03946 NDUFA2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2 [EC:1.6.5.3 1.6.99.3]
K03947 NDUFA3; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 3 [EC:1.6.5.3 1.6.99.3]
K03948 NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 [EC:1.6.5.3 1.6.99.3]
K03949 NDUFA5; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 5 [EC:1.6.5.3 1.6.99.3]
K03950 NDUFA6; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 6 [EC:1.6.5.3 1.6.99.3]
K03951 NDUFA7; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 7 [EC:1.6.5.3 1.6.99.3]
K03952 NDUFA8; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 8 [EC:1.6.5.3 1.6.99.3]
K03953 NDUFA9; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 9 [EC:1.6.5.3 1.6.99.3]
K03954 NDUFA10; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10 [EC:1.6.5.3 1.6.99.3]
K03955 NDUFAB1; NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1 [EC:1.6.5.3 1.6.99.3]
K03956 NDUFA11; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11 [EC:1.6.5.3]
K11352 NDUFA12; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 12 [EC:1.6.5.3 1.6.99.3]
K11353 NDUFA13; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 13 [EC:1.6.5.3 1.6.99.3]
K03957 NDUFB1; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 1 [EC:1.6.5.3 1.6.99.3]
K03958 NDUFB2; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 2 [EC:1.6.5.3 1.6.99.3]
K03959 NDUFB3; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 [EC:1.6.5.3 1.6.99.3]
K03960 NDUFB4; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4 [EC:1.6.5.3 1.6.99.3]
K03961 NDUFB5; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 5 [EC:1.6.5.3 1.6.99.3]
K03962 NDUFB6; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 6 [EC:1.6.5.3 1.6.99.3]
K03963 NDUFB7; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 7 [EC:1.6.5.3 1.6.99.3]
K03964 NDUFB8; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 [EC:1.6.5.3 1.6.99.3]
K03965 NDUFB9; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 9 [EC:1.6.5.3 1.6.99.3]
K03966 NDUFB10; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 10 [EC:1.6.5.3 1.6.99.3]
K11351 NDUFB11; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 11 [EC:1.6.5.3 1.6.99.3]
K03934 NDUFS1; NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:1.6.5.3 1.6.99.3]
K03935 NDUFS2; NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:1.6.5.3 1.6.99.3]
K03936 NDUFS3; NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:1.6.5.3 1.6.99.3]
K03937 NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4 [EC:1.6.5.3 1.6.99.3]
K03938 NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5 [EC:1.6.5.3 1.6.99.3]
K03939 NDUFS6; NADH dehydrogenase (ubiquinone) Fe-S protein 6 [EC:1.6.5.3 1.6.99.3]
K03940 NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:1.6.5.3 1.6.99.3]
K03941 NDUFS8; NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:1.6.5.3 1.6.99.3]
K03967 NDUFC1; NADH dehydrogenase (ubiquinone) 1 subcomplex unknown 1 [EC:1.6.5.3 1.6.99.3]
K03968 NDUFC2; NADH dehydrogenase (ubiquinone) 1 subcomplex unknown 2 [EC:1.6.5.3 1.6.99.3]
K00234 SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
K00235 SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
K00236 SDHC, SDH3; succinate dehydrogenase (ubiquinone) cytochrome b560 subunit
K00237 SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit
K00411 UQCRFS1, RIP1, petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:1.10.2.2]
K00412 CYTB, petB; ubiquinol-cytochrome c reductase cytochrome b subunit
K00413 CYC1, CYT1, petC; ubiquinol-cytochrome c reductase cytochrome c1 subunit
K00414 QCR1, UQCRC1; ubiquinol-cytochrome c reductase core subunit 1
K00415 QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
K00416 QCR6, UQCRH; ubiquinol-cytochrome c reductase subunit 6
K00417 QCR7, UQCRB; ubiquinol-cytochrome c reductase subunit 7
K00418 QCR8, UQCRQ; ubiquinol-cytochrome c reductase subunit 8
K00419 QCR9, UCRC; ubiquinol-cytochrome c reductase subunit 9
K00420 QCR10, UQCR; ubiquinol-cytochrome c reductase subunit 10
K02262 COX3; cytochrome c oxidase subunit 3
K02256 COX1; cytochrome c oxidase subunit 1 [EC:1.9.3.1]
K02261 COX2; cytochrome c oxidase subunit 2
K02263 COX4; cytochrome c oxidase subunit 4
K02264 COX5A; cytochrome c oxidase subunit 5a
K02265 COX5B; cytochrome c oxidase subunit 5b
K02266 COX6A; cytochrome c oxidase subunit 6a
K02267 COX6B; cytochrome c oxidase subunit 6b
K02268 COX6C; cytochrome c oxidase subunit 6c
K02270 COX7A; cytochrome c oxidase subunit 7a
K02271 COX7B; cytochrome c oxidase subunit 7b
K02272 COX7C; cytochrome c oxidase subunit 7c
K02273 COX8; cytochrome c oxidase subunit 8
K02132 ATPeF1A, ATP5A1; F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14]
K02133 ATPeF1B, ATP5B; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14]
K02136 ATPeF1G, ATP5C1; F-type H+-transporting ATPase subunit gamma [EC:3.6.3.14]
K02134 ATPeF1D, ATP5D; F-type H+-transporting ATPase subunit delta [EC:3.6.3.14]
K02135 ATPeF1E, ATP5E; F-type H+-transporting ATPase subunit epsilon [EC:3.6.3.14]
K02126 ATPeF0A, MTATP6; F-type H+-transporting ATPase subunit a [EC:3.6.3.14]
K02127 ATPeF0B, ATP5F1; F-type H+-transporting ATPase subunit b [EC:3.6.3.14]
K02128 ATPeF0C, ATP5G; F-type H+-transporting ATPase subunit c [EC:3.6.3.14]
K02138 ATPeFD, ATP5H; F-type H+-transporting ATPase subunit d [EC:3.6.3.14]
K02137 ATPeF1O, ATP5O; F-type H+-transporting ATPase oligomycin sensitivity conferral protein [EC:3.6.3.14]
K02131 ATPeF0F6, ATP5J; F-type H+-transporting ATPase subunit 6 [EC:3.6.3.14]
K02125 ATPeF08, MTATP8; F-type H+-transporting ATPase subunit 8 [EC:3.6.3.14]
K05862 VDAC1; voltage-dependent anion channel protein 1
K15040 VDAC2; voltage-dependent anion channel protein 2
K15041 VDAC3; voltage-dependent anion channel protein 3
K05863 SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31
K09565 PPIF; peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04399 CASP9; caspase 9 [EC:3.4.22.62]
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05020 Prion diseases [PATH:ko05020]
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Substance dependence
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Cardiovascular diseases
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Endocrine and metabolic diseases
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Infectious diseases
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05110 Vibrio cholerae infection [PATH:ko05110]
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05111 Vibrio cholerae pathogenic cycle [PATH:ko05111]
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05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
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05130 Pathogenic Escherichia coli infection [PATH:ko05130]
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05132 Salmonella infection [PATH:ko05132]
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05131 Shigellosis [PATH:ko05131]
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05133 Pertussis [PATH:ko05133]
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05134 Legionellosis [PATH:ko05134]
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05150 Staphylococcus aureus infection [PATH:ko05150]
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05152 Tuberculosis [PATH:ko05152]
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05100 Bacterial invasion of epithelial cells [PATH:ko05100]
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K13730 inlA; internalin A
K13731 inlB; internalin B
K13732 fnbA; fibronectin-binding protein A
K13733 fnbB; fibronectin-binding protein B
K13925 pfbA; plasmin and fibronectin-binding protein A
K13734 sfb1; fibronectin-binding protein 1
K13735 yeeJ; adhesin/invasin
K05689 CDHE, CDH1; cadherin 1, type 1, E-cadherin
K02105 CTNNB1; catenin beta 1
K05691 CTNNA; catenin alpha
K13736 ARHGAP10; Rho GTPase-activating protein 10
K05099 MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K09593 GAB1; GRB2-associated-binding protein 1
K02649 PIK3R; phosphoinositide-3-kinase, regulatory subunit
K00922 PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
K04438 CRK, CRKII; proto-oncogene C-crk
K13708 DOCK1; dedicator of cytokinesis 1
K04393 CDC42; cell division control protein 42
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K05747 WAS; Wiskott-Aldrich syndrome protein
K05753 WASF1; WAS protein family, member 1
K05748 WASF2; WAS protein family, member 2
K05757 ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
K05758 ARPC2; actin related protein 2/3 complex, subunit 2
K05756 ARPC3; actin related protein 2/3 complex, subunit 3
K05755 ARPC4; actin related protein 2/3 complex, subunit 4
K05754 ARPC5; actin related protein 2/3 complex, subunit 5
K05692 ACTB_G1; actin beta/gamma 1
K13737 SEPT1; septin 1
K16942 SEPT2; septin 2
K16938 SEPT3_9_12; septin 3/9/12
K16939 SEPT6_8_11; septin 6/8/11
K04707 CBL; E3 ubiquitin-protein ligase CBL [EC:6.3.2.19]
K06279 SHC; src homology 2 domain-containing transforming protein C
K13738 CD2AP; CD2-associated protein
K01528 DNM; dynamin GTPase [EC:3.6.5.5]
K04644 CLTA, LCA; clathrin light chain A
K04645 CLTB, LCB; clathrin light chain B
K04646 CLTC; clathrin heavy chain
K06278 CAV1; caveolin 1
K12958 CAV2; caveolin 2
K12959 CAV3; caveolin 3
K06106 CTTN, EMS1; cortactin
K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
K05725 PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
K05726 BCAR1, CAS; breast cancer anti-estrogen resistance 1
K05760 PXN; paxillin
K05717 FN1; fibronectin 1
K06484 ITGA5; integrin alpha 5
K05719 ITGB1; integrin beta 1
K06272 ILK; integrin-linked kinase [EC:2.7.11.1]
K13287 sipD, ipaD, bipD; invasin D
K13286 sipC, ipaC, bipC; invasin C
K13285 sipB, ipaB, bipB; invasin B
K13739 sopD; secreted effector protein SopD
K13284 sipA, ipaA; invasin A
K13740 sptP; secreted effector protein SptP
K13741 sopE; guanine nucleotide exchange factor SopE
K13085 ipgD, sopB; phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78]
K13742 ipgB1; protein IpgB1
K13743 ipgB2; protein IpgB2
K12785 espG, virA; LEE-encoded effector EspG
K13728 MAD2L2; mitotic spindle assembly checkpoint protein MAD2B
K13744 SGEF; SH3 domain-containing guanine exchange factor
K07863 RHOG; Ras homolog gene family, member G
K12366 ELMO1, CED12; engulfment and cell motility protein 1
K04513 RHOA; Ras homolog gene family, member A
K05700 VCL; vinculin
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05166 HTLV-I infection [PATH:ko05166]
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05162 Measles [PATH:ko05162]
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05164 Influenza A [PATH:ko05164]
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05161 Hepatitis B [PATH:ko05161]
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05160 Hepatitis C [PATH:ko05160]
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05168 Herpes simplex infection [PATH:ko05168]
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05169 Epstein-Barr virus infection [PATH:ko05169]
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05146 Amoebiasis [PATH:ko05146]
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05144 Malaria [PATH:ko05144]
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05145 Toxoplasmosis [PATH:ko05145]
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05140 Leishmaniasis [PATH:ko05140]
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05142 Chagas disease (American trypanosomiasis) [PATH:ko05142]
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05143 African trypanosomiasis [PATH:ko05143]
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KEGG Orthology (KO)