KEGG Orthology (KO)

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 Environmental Information Processing
 
   Membrane transport
 
   Signal transduction
     02020 Two-component system [PATH:ko02020]
     02022 Two-component system [BR:ko02022]
     04014 Ras signaling pathway [PATH:ko04014]
       K04357  EGF; epidermal growth factor
       K08774  TGFA; transforming growth factor, alpha
       K18496  FGF1; fibroblast growth factor 1
       K18497  FGF2; fibroblast growth factor 2
       K04358  FGF; fibroblast growth factor
       K05451  NGFA; nerve growth factor, alpha
       K02582  NGFB; nerve growth factor, beta
       K04355  BDNF; brain-derived neurotrophic factor
       K04356  NTF3; neurotrophin 3
       K12457  NTF4; neurotrophin 4
       K04526  INS; insulin
       K05459  IGF1; insulin-like growth factor 1
       K13769  IGF2; insulin-like growth factor 2
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K05450  PDGFC_D; platelet derived growth factor C/D
       K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
       K05461  KITLG; KIT ligand
       K05454  FLT3LG; fms-related tyrosine kinase 3 ligand
       K05448  VEGFA; vascular endothelial growth factor A
       K16858  VEGFB; vascular endothelial growth factor B
       K16859  PGF; placenta growth factor
       K05449  VEGFC_D; vascular endothelial growth factor C/D
       K05460  HGF; hepatocyte growth factor
       K05465  ANGPT1; angiopoietin 1
       K05466  ANGPT2; angiopoietin 2
       K05467  ANGPT4; angiopoietin 4
       K05462  EFNA; ephrin-A
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K04362  FGFR1, CD331; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K05093  FGFR2, CD332; fibroblast growth factor receptor 2 [EC:2.7.10.1]
       K05094  FGFR3, CD333; fibroblast growth factor receptor 3 [EC:2.7.10.1]
       K05095  FGFR4, CD334; fibroblast growth factor receptor 4 [EC:2.7.10.1]
       K02583  NGFR, CD271; nerve growth factor receptor (TNFR superfamily member 16)
       K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
       K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]
       K04527  INSR, CD220; insulin receptor [EC:2.7.10.1]
       K05087  IGF1R, CD221; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
       K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3 [EC:2.7.10.1]
       K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
       K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
       K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor [EC:2.7.10.1]
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
       K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]
       K05103  EPHA2, ECK; Eph receptor A2 [EC:2.7.10.1]
       K04364  GRB2; growth factor receptor-binding protein 2
       K09593  GAB1; GRB2-associated-binding protein 1
       K08091  GAB2; growth factor receptor bound protein 2-associated protein 2
       K06279  SHC1; SHC-transforming protein 1
       K17447  SHC2; SHC-transforming protein 2
       K17448  SHC3; SHC-transforming protein 3
       K17449  SHC4; SHC-transforming protein 4
       K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
       K03099  SOS; son of sevenless
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K04350  RASGRP1; RAS guanyl-releasing protein 1
       K12361  RASGRP2; RAS guanyl-releasing protein 2
       K12362  RASGRP3; RAS guanyl-releasing protein 3
       K12363  RASGRP4; RAS guanyl-releasing protein 4
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K07360  ZAP70; tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]
       K07362  LAT; linker for activation of T cells
       K04163  HTR7; 5-hydroxytryptamine receptor 7
       K04536  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
       K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
       K07825  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
       K04538  GNB4; guanine nucleotide-binding protein subunit beta-4
       K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
       K07826  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
       K04540  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
       K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
       K04542  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
       K04543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
       K04544  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
       K04545  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
       K04546  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K04547  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
       K04548  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
       K04549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K04349  RASGRF1; Ras-specific guanine nucleotide-releasing factor 1
       K12326  RASGRF2; Ras-specific guanine nucleotide-releasing factor 2
       K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
       K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
       K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
       K02183  CALM; calmodulin
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K07831  MRAS; Ras-related protein M-Ras
       K07829  RRAS; Ras-related protein R-Ras
       K07830  RRAS2, TC21; Ras-related protein R-Ras2
       K08052  NF1; neurofibromin 1
       K04352  RASA1, RASGAP; Ras GTPase-activating protein 1
       K08053  RASA2, GAP1M; Ras GTPase-activating protein 2
       K12380  RASA3; Ras GTPase-activating protein 3
       K17630  RASA4, CAPRI; Ras GTPase-activating protein 4
       K17631  SYNGAP, RASA5; Ras/Rap GTPase-activating protein SynGAP
       K17632  RASAL1; RAS protein activator-like 1
       K17633  RASAL2; RAS protein activator-like 2
       K17634  RASAL3; RAS protein activator-like 3
       K09850  RASSF1; Ras association domain-containing protein 1
       K08015  RASSF5, RAPL; Ras association domain-containing protein 5
       K04411  STK4, MST1; serine/threonine kinase 4
       K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
       K04410  PAK2; p21-activated kinase 2 [EC:2.7.11.1]
       K05733  PAK3, MRX30; p21-activated kinase 3 [EC:2.7.11.1]
       K05734  PAK4; p21-activated kinase 4 [EC:2.7.11.1]
       K05735  PAK6; p21-activated kinase 6 [EC:2.7.11.1]
       K05736  PAK7; p21-activated kinase 7 [EC:2.7.11.1]
       K04513  RHOA; Ras homolog gene family, member A
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K02158  BAD; Bcl-2-antagonist of cell death
       K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
       K12358  FOXO4; forkhead box protein O4
       K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
       K05702  AF6, MLLT4; afadin
       K19613  SHOC2, SUR8; leucine-rich repeat protein SHOC2
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K13618  PLA1A; phospholipase A1 member A [EC:3.1.1.-]
       K01047  PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]
       K16342  PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]
       K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2 [EC:3.1.1.4]
       K16817  PLA2G16; HRAS-like suppressor 3 [EC:3.1.1.32 3.1.1.4]
       K04375  ELK1; ETS domain-containing protein Elk-1
       K02678  ETS1, pnt; C-ets-1
       K21932  ETS2; C-ets-2
       K10632  BRAP; BRCA1-associated protein [EC:2.3.2.27]
       K14958  KSR1; kinase suppressor of Ras 1
       K18529  KSR2; kinase suppressor of Ras 2 [EC:2.7.11.1]
       K08019  RAPGEF5; Rap guanine nucleotide exchange factor 5
       K04353  RAP1A; Ras-related protein Rap-1A
       K07836  RAP1B; Ras-related protein Rap-1B
       K08732  RALGDS; ral guanine nucleotide dissociation stimulator
       K17635  RGL1, RGL; ral guanine nucleotide dissociation stimulator-like 1
       K17636  RGL2; ral guanine nucleotide dissociation stimulator-like 2
       K07834  RALA; Ras-related protein Ral-A
       K07835  RALB; Ras-related protein Ral-B
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K17637  EXOC2, SEC5; exocyst complex component 2
       K05410  TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
       K09254  REL; c-Rel proto-oncogene protein
       K01115  PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
       K08773  RALBP1; RalA-binding protein 1
       K04393  CDC42; cell division control protein 42
       K05860  PLCE; phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
       K02677  PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
       K19662  PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
       K19663  PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
       K17638  RIN1; Ras and Rab interactor 1
       K06619  ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
       K08887  ABL2; abelson tyrosine-protein kinase 2 [EC:2.7.10.2]
       K07887  RAB5A; Ras-related protein Rab-5A
       K07888  RAB5B; Ras-related protein Rab-5B
       K07889  RAB5C; Ras-related protein Rab-5C
       K07941  ARF6; ADP-ribosylation factor 6
     04015 Rap1 signaling pathway [PATH:ko04015]
       K04353  RAP1A; Ras-related protein Rap-1A
       K07836  RAP1B; Ras-related protein Rap-1B
       K07831  MRAS; Ras-related protein M-Ras
       K08019  RAPGEF5; Rap guanine nucleotide exchange factor 5
       K17697  DOCK4; dedicator of cytokinesis protein 4
       K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
       K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
       K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
       K02183  CALM; calmodulin
       K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
       K04236  F2RL3, PAR4; coagulation factor II (thrombin) receptor-like 3
       K04270  P2RY1; purinergic receptor P2Y, G protein-coupled, 1
       K04172  FPR1; formyl peptide receptor 1
       K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
       K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
       K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
       K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
       K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
       K04266  ADORA2A, ADOR; adenosine receptor A2a
       K04267  ADORA2B; adenosine receptor A2b
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
       K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K12362  RASGRP3; RAS guanyl-releasing protein 3
       K12361  RASGRP2; RAS guanyl-releasing protein 2
       K04357  EGF; epidermal growth factor
       K18496  FGF1; fibroblast growth factor 1
       K18497  FGF2; fibroblast growth factor 2
       K04358  FGF; fibroblast growth factor
       K05451  NGFA; nerve growth factor, alpha
       K02582  NGFB; nerve growth factor, beta
       K04526  INS; insulin
       K05459  IGF1; insulin-like growth factor 1
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K05450  PDGFC_D; platelet derived growth factor C/D
       K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
       K05461  KITLG; KIT ligand
       K05448  VEGFA; vascular endothelial growth factor A
       K16858  VEGFB; vascular endothelial growth factor B
       K16859  PGF; placenta growth factor
       K05449  VEGFC_D; vascular endothelial growth factor C/D
       K05460  HGF; hepatocyte growth factor
       K05465  ANGPT1; angiopoietin 1
       K05466  ANGPT2; angiopoietin 2
       K05467  ANGPT4; angiopoietin 4
       K05462  EFNA; ephrin-A
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K04362  FGFR1, CD331; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K05093  FGFR2, CD332; fibroblast growth factor receptor 2 [EC:2.7.10.1]
       K05094  FGFR3, CD333; fibroblast growth factor receptor 3 [EC:2.7.10.1]
       K05095  FGFR4, CD334; fibroblast growth factor receptor 4 [EC:2.7.10.1]
       K02583  NGFR, CD271; nerve growth factor receptor (TNFR superfamily member 16)
       K04527  INSR, CD220; insulin receptor [EC:2.7.10.1]
       K05087  IGF1R, CD221; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
       K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
       K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
       K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor [EC:2.7.10.1]
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
       K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]
       K05103  EPHA2, ECK; Eph receptor A2 [EC:2.7.10.1]
       K04438  CRK, CRKII; proto-oncogene C-crk
       K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
       K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
       K05689  CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
       K02105  CTNNB1; catenin beta 1
       K05631  AIP3, WWP3, BAIAP1; atrophin-1 interacting protein 3 (BAI1-associated protein 1)
       K05629  AIP1; atrophin-1 interacting protein 1
       K06112  MAGI3; membrane-associated guanylate kinase-related
       K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2
       K08020  RAPGEF6, PDZGEF2; Rap guanine nucleotide exchange factor 6
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K07362  LAT; linker for activation of T cells
       K17698  FYB, ADAP; FYN binding protein
       K07361  LCP2; lymphocyte cytosolic protein 2
       K17699  SKAP1, SKAP55; src kinase associated phosphoprotein 1
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K02677  PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
       K19662  PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
       K19663  PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
       K06070  PKD; protein kinase D [EC:2.7.11.13]
       K04145  DRD2; dopamine receptor D2
       K04277  CNR1; cannabinoid receptor 1
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
       K17700  RAP1GAP, RAPGAP; RAP1 GTPase activating protein 1
       K17701  SIPA1L1, E6TP1; signal-induced proliferation-associated 1 like protein 1
       K08013  SIPA1; signal-induced proliferation-associated gene 1
       K17702  SIPA1L2, SPAL2; signal-induced proliferation-associated 1 like protein 2
       K17703  SIPA1L3, SPAL3; signal-induced proliferation-associated 1 like protein 3
       K04680  ID1; DNA-binding protein inhibitor ID1
       K16857  THBS1; thrombospondin 1
       K08732  RALGDS; ral guanine nucleotide dissociation stimulator
       K07834  RALA; Ras-related protein Ral-A
       K07835  RALB; Ras-related protein Ral-B
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K17704  APBB1IP, RIAM; amyloid beta A4 precursor protein-binding family B member 1-interacting protein
       K06271  TLN; talin
       K06476  ITGA2B, CD41; integrin alpha 2B
       K06493  ITGB3, CD61; integrin beta 3
       K05759  PFN; profilin
       K06274  VASP; vasodilator-stimulated phosphoprotein
       K05692  ACTB_G1; actin beta/gamma 1
       K12490  ARAP3; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
       K04513  RHOA; Ras homolog gene family, member A
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K06082  FARP2, FRG; FERM, RhoGEF and pleckstrin domain protein 2
       K04393  CDC42; cell division control protein 42
       K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
       K04237  PARD3; partitioning defective protein 3
       K06093  PARD6; partitioning defective protein 6
       K18952  PRKCZ; atypical protein kinase C zeta type [EC:2.7.11.13]
       K06069  PRKCI; atypical protein kinase C iota type [EC:2.7.11.13]
       K05702  AF6, MLLT4; afadin
       K05690  CTNND1; catenin (cadherin-associated protein), delta 1
       K17705  KRIT1; Krev interaction trapped protein 1
       K17706  RGS14; regulator of G-protein signaling 14
       K08015  RASSF5, RAPL; Ras association domain-containing protein 5
       K05718  ITGAL, CD11a; integrin alpha L
       K06461  ITGAM, CD11b; integrin alpha M
       K06464  ITGB2, CD18; integrin beta 2
       K05719  ITGB1, CD29; integrin beta 1
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
       K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K05860  PLCE; phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K07829  RRAS; Ras-related protein R-Ras
     04010 MAPK signaling pathway [PATH:ko04010]
       K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
       K04849  CACNA1B; voltage-dependent calcium channel N type alpha-1B
       K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
       K04851  CACNA1D; voltage-dependent calcium channel L type alpha-1D
       K04852  CACNA1E; voltage-dependent calcium channel R type alpha-1E
       K04853  CACNA1F; voltage-dependent calcium channel L type alpha-1F
       K04854  CACNA1G; voltage-dependent calcium channel T type alpha-1G
       K04855  CACNA1H; voltage-dependent calcium channel T type alpha-1H
       K04856  CACNA1I; voltage-dependent calcium channel T type alpha-1I
       K04857  CACNA1S; voltage-dependent calcium channel L type alpha-1S
       K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
       K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
       K04860  CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
       K04861  CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
       K04862  CACNB1; voltage-dependent calcium channel beta-1
       K04863  CACNB2; voltage-dependent calcium channel beta-2
       K04864  CACNB3; voltage-dependent calcium channel beta-3
       K04865  CACNB4; voltage-dependent calcium channel beta-4
       K04866  CACNG1; voltage-dependent calcium channel gamma-1
       K04867  CACNG2; voltage-dependent calcium channel gamma-2
       K04868  CACNG3; voltage-dependent calcium channel gamma-3
       K04869  CACNG4; voltage-dependent calcium channel gamma-4
       K04870  CACNG5; voltage-dependent calcium channel gamma-5
       K04871  CACNG6; voltage-dependent calcium channel gamma-6
       K04872  CACNG7; voltage-dependent calcium channel gamma-7
       K04873  CACNG8; voltage-dependent calcium channel gamma-8
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K02677  PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
       K19662  PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
       K19663  PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
       K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K04349  RASGRF1; Ras-specific guanine nucleotide-releasing factor 1
       K12326  RASGRF2; Ras-specific guanine nucleotide-releasing factor 2
       K04350  RASGRP1; RAS guanyl-releasing protein 1
       K12361  RASGRP2; RAS guanyl-releasing protein 2
       K12362  RASGRP3; RAS guanyl-releasing protein 3
       K12363  RASGRP4; RAS guanyl-releasing protein 4
       K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2
       K08052  NF1; neurofibromin 1
       K04352  RASA1, RASGAP; Ras GTPase-activating protein 1
       K08053  RASA2, GAP1M; Ras GTPase-activating protein 2
       K04353  RAP1A; Ras-related protein Rap-1A
       K07836  RAP1B; Ras-related protein Rap-1B
       K04357  EGF; epidermal growth factor
       K08774  TGFA; transforming growth factor, alpha
       K18496  FGF1; fibroblast growth factor 1
       K18497  FGF2; fibroblast growth factor 2
       K04358  FGF; fibroblast growth factor
       K05451  NGFA; nerve growth factor, alpha
       K02582  NGFB; nerve growth factor, beta
       K04355  BDNF; brain-derived neurotrophic factor
       K04356  NTF3; neurotrophin 3
       K12457  NTF4; neurotrophin 4
       K04526  INS; insulin
       K05459  IGF1; insulin-like growth factor 1
       K13769  IGF2; insulin-like growth factor 2
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K05450  PDGFC_D; platelet derived growth factor C/D
       K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
       K05461  KITLG; KIT ligand
       K05454  FLT3LG; fms-related tyrosine kinase 3 ligand
       K05448  VEGFA; vascular endothelial growth factor A
       K16858  VEGFB; vascular endothelial growth factor B
       K16859  PGF; placenta growth factor
       K05449  VEGFC_D; vascular endothelial growth factor C/D
       K05460  HGF; hepatocyte growth factor
       K05465  ANGPT1; angiopoietin 1
       K05466  ANGPT2; angiopoietin 2
       K05467  ANGPT4; angiopoietin 4
       K05462  EFNA; ephrin-A
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K04362  FGFR1, CD331; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K05093  FGFR2, CD332; fibroblast growth factor receptor 2 [EC:2.7.10.1]
       K05094  FGFR3, CD333; fibroblast growth factor receptor 3 [EC:2.7.10.1]
       K05095  FGFR4, CD334; fibroblast growth factor receptor 4 [EC:2.7.10.1]
       K02583  NGFR, CD271; nerve growth factor receptor (TNFR superfamily member 16)
       K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
       K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]
       K04527  INSR, CD220; insulin receptor [EC:2.7.10.1]
       K05087  IGF1R, CD221; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
       K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3 [EC:2.7.10.1]
       K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
       K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
       K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor [EC:2.7.10.1]
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
       K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]
       K05103  EPHA2, ECK; Eph receptor A2 [EC:2.7.10.1]
       K04364  GRB2; growth factor receptor-binding protein 2
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K07829  RRAS; Ras-related protein R-Ras
       K07830  RRAS2, TC21; Ras-related protein R-Ras2
       K07831  MRAS; Ras-related protein M-Ras
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04370  LAMTOR3, MP1, MAP2K1IP1; ragulator complex protein LAMTOR3
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04372  MKNK, MNK; MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]
       K04373  RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K04375  ELK1; ETS domain-containing protein Elk-1
       K04376  ELK4, SAP1; ETS domain-containing protein Elk-4
       K04377  MYC; Myc proto-oncogene protein
       K04378  SRF; serum response factor
       K04379  FOS; proto-oncogene protein c-fos
       K04380  MAPT, TAU; microtubule-associated protein tau
       K04381  STMN1; stathmin
       K16342  PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]
       K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
       K04383  IL1A; interleukin 1 alpha
       K04519  IL1B; interleukin 1 beta
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
       K04386  IL1R1, CD121a; interleukin 1 receptor type I
       K04723  IL1RAP; interleukin 1 receptor accessory protein
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
       K04391  CD14; monocyte differentiation antigen CD14
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K04393  CDC42; cell division control protein 42
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
       K02308  DAXX; death-associated protein 6
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K04730  IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K03175  TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
       K04402  GADD45; growth arrest and DNA-damage-inducible protein
       K04403  MAP3K7IP1, TAB1; TAK1-binding protein 1
       K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
       K04405  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway
       K04406  MAP4K3, GLK; mitogen-activated protein kinase kinase kinase kinase 3 [EC:2.7.11.1]
       K04407  MAP4K4, HGK; mitogen-activated protein kinase kinase kinase kinase 4 [EC:2.7.11.1]
       K04408  MAP4K1, HPK1; mitogen-activated protein kinase kinase kinase kinase 1 [EC:2.7.11.1]
       K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
       K04410  PAK2; p21-activated kinase 2 [EC:2.7.11.1]
       K04411  STK4, MST1; serine/threonine kinase 4
       K04412  STK3, MST2; serine/threonine kinase 3
       K04414  MAP4K2, GCK; mitogen-activated protein kinase kinase kinase kinase 2 [EC:2.7.11.1]
       K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8 [EC:2.7.11.25]
       K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
       K04419  MAP3K11, MLK3; mitogen-activated protein kinase kinase kinase 11 [EC:2.7.11.25]
       K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2 [EC:2.7.11.25]
       K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]
       K04422  MAP3K13, LZK; mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25]
       K04423  MAP3K12, MUK; mitogen-activated protein kinase kinase kinase 12 [EC:2.7.11.25]
       K04424  ZAK, MLTK; sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25]
       K04425  MAP3K6, ASK2; mitogen-activated protein kinase kinase kinase 6 [EC:2.7.11.25]
       K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25]
       K04429  TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]
       K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
       K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
       K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
       K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
       K04434  MAPK8IP1, JIP1; mitogen-activated protein kinase 8 interacting protein 1
       K04435  MAPK8IP2, JIP2; mitogen-activated protein kinase 8 interacting protein 2
       K04436  MAPK8IP3, JIP3; mitogen-activated protein kinase 8 interacting protein 3
       K04437  FLNA; filamin
       K04438  CRK, CRKII; proto-oncogene C-crk
       K04439  ARRB; beta-arrestin
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04442  MAPKAPK5, PRAK; mitogen-activated protein kinase-activated protein kinase 5 [EC:2.7.11.1]
       K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
       K04444  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]
       K04445  RPS6KA5, MSK1; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
       K16510  RPS6KA4, MSK2; ribosomal protein S6 kinase alpha-4 [EC:2.7.11.1]
       K05866  CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
       K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
       K17333  NFATC3, NFAT4; nuclear factor of activated T-cells, cytoplasmic 3
       K04448  JUN; transcription factor AP-1
       K04449  JUND; transcription factor jun-D
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04451  TP53, P53; tumor protein p53
       K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
       K04453  MAX; Max protein
       K04454  MEF2C; MADS-box transcription enhancer factor 2C
       K04455  HSPB1; heat shock protein beta-1
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04457  PPM1A, PP2CA; protein phosphatase 1A [EC:3.1.3.16]
       K04458  PTPRR; receptor-type tyrosine-protein phosphatase R [EC:3.1.3.48]
       K18018  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [EC:3.1.3.48]
       K18019  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [EC:3.1.3.48]
       K21278  DUSP1; dual specificity protein phosphatase 1 [EC:3.1.3.16 3.1.3.48]
       K04459  DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]
       K21946  DUSP6; dual specificity phosphatase 6 [EC:3.1.3.16 3.1.3.48]
       K18498  DUSP9, MKP4; dual specificity phosphatase 9 [EC:3.1.3.16 3.1.3.48]
       K20216  DUSP10; dual specificity phosphatase 10 [EC:3.1.3.16 3.1.3.48]
       K17614  DUSP3, VHR; dual specificity phosphatase 3 [EC:3.1.3.16 3.1.3.48]
       K04460  PPP5C; serine/threonine-protein phosphatase 5 [EC:3.1.3.16]
       K04461  PPM1B, PP2CB; protein phosphatase 1B [EC:3.1.3.16]
       K03283  HSPA1s; heat shock 70kDa protein 1/2/6/8
       K04462  EVI1; ecotropic virus integration site 1 protein
       K04463  MAP2K5, MEK5; mitogen-activated protein kinase kinase 5 [EC:2.7.12.2]
       K04464  MAPK7; mitogen-activated protein kinase 7 [EC:2.7.11.24]
       K04465  NR4A1, HMR; nuclear receptor subfamily 4 group A member 1
       K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04468  NLK; nemo like kinase [EC:2.7.11.24]
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04469  NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
       K04735  RELA; transcription factor p65
       K09253  RELB; transcription factor RelB
     04013 MAPK signaling pathway - fly [PATH:ko04013]
     04016 MAPK signaling pathway - plant [PATH:ko04016]
     04011 MAPK signaling pathway - yeast [PATH:ko04011]
     04012 ErbB signaling pathway [PATH:ko04012]
     04310 Wnt signaling pathway [PATH:ko04310]
     04330 Notch signaling pathway [PATH:ko04330]
     04340 Hedgehog signaling pathway [PATH:ko04340]
     04341 Hedgehog signaling pathway - fly [PATH:ko04341]
     04350 TGF-beta signaling pathway [PATH:ko04350]
     04390 Hippo signaling pathway [PATH:ko04390]
     04391 Hippo signaling pathway -fly [PATH:ko04391]
     04392 Hippo signaling pathway - multiple species [PATH:ko04392]
     04370 VEGF signaling pathway [PATH:ko04370]
     04371 Apelin signaling pathway [PATH:ko04371]
     04630 Jak-STAT signaling pathway [PATH:ko04630]
     04064 NF-kappa B signaling pathway [PATH:ko04064]
     04668 TNF signaling pathway [PATH:ko04668]
     04066 HIF-1 signaling pathway [PATH:ko04066]
       K05405  IL6; interleukin 6
       K05055  IL6R, CD126; interleukin 6 receptor
       K04692  STAT3; signal transducer and activator of transcription 3
       K10160  TLR4, CD284; toll-like receptor 4
       K04687  IFNG; interferon gamma
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K04735  RELA; transcription factor p65
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04526  INS; insulin
       K04357  EGF; epidermal growth factor
       K05459  IGF1; insulin-like growth factor 1
       K04527  INSR, CD220; insulin receptor [EC:2.7.10.1]
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K05087  IGF1R, CD221; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04372  MKNK, MNK; MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
       K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
       K03259  EIF4E; translation initiation factor 4E
       K04688  RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
       K02991  RP-S6e, RPS6; small subunit ribosomal protein S6e
       K08268  HIF1A; hypoxia-inducible factor 1 alpha
       K03871  VHL; von Hippel-Lindau disease tumor supressor
       K03868  RBX1, ROC1; RING-box protein 1
       K03872  TCEB1; transcription elongation factor B, polypeptide 1
       K03873  TCEB2; transcription elongation factor B, polypeptide 2
       K03870  CUL2; cullin 2
       K09592  EGLN, HPH; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
       K09097  ARNT; aryl hydrocarbon receptor nuclear translocator
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K21421  NOX2, GP91, CYBB; NADPH oxidase 2 [EC:1.-.-.-]
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K02677  PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
       K19662  PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
       K19663  PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]
       K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
       K16451  TIMP1; metallopeptidase inhibitor 1
       K03159  TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3
       K05437  EPO; erythropoietin
       K14736  TF; transferrin
       K06503  TFRC, CD71; transferrin receptor
       K05448  VEGFA; vascular endothelial growth factor A
       K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
       K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
       K05465  ANGPT1; angiopoietin 1
       K05466  ANGPT2; angiopoietin 2
       K05467  ANGPT4; angiopoietin 4
       K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]
       K16366  EDN1; endothelin-1
       K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
       K13242  NOS3; nitric-oxide synthase, endothelial [EC:1.14.13.39]
       K00510  HMOX1; heme oxygenase 1 [EC:1.14.14.18]
       K12334  NPPA; natriuretic peptide A
       K07299  SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
       K12077  PDK1; pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2]
       K00844  HK; hexokinase [EC:2.7.1.1]
       K00134  GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]
       K01689  ENO, eno; enolase [EC:4.2.1.11]
       K01103  PFKFB3; 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 3  [EC:2.7.1.105 3.1.3.46]
       K02161  BCL2; apoptosis regulator Bcl-2
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K00161  PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
       K00162  PDHB, pdhB; pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
     04068 FoxO signaling pathway [PATH:ko04068]
     04020 Calcium signaling pathway [PATH:ko04020]
     04070 Phosphatidylinositol signaling system [PATH:ko04070]
     04072 Phospholipase D signaling pathway [PATH:ko04072]
     04071 Sphingolipid signaling pathway [PATH:ko04071]
     04024 cAMP signaling pathway [PATH:ko04024]
     04022 cGMP - PKG signaling pathway [PATH:ko04022]
     04151 PI3K-Akt signaling pathway [PATH:ko04151]
       K04357  EGF; epidermal growth factor
       K08774  TGFA; transforming growth factor, alpha
       K18496  FGF1; fibroblast growth factor 1
       K18497  FGF2; fibroblast growth factor 2
       K04358  FGF; fibroblast growth factor
       K05451  NGFA; nerve growth factor, alpha
       K02582  NGFB; nerve growth factor, beta
       K04355  BDNF; brain-derived neurotrophic factor
       K04356  NTF3; neurotrophin 3
       K12457  NTF4; neurotrophin 4
       K04526  INS; insulin
       K05459  IGF1; insulin-like growth factor 1
       K13769  IGF2; insulin-like growth factor 2
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K05450  PDGFC_D; platelet derived growth factor C/D
       K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
       K05461  KITLG; KIT ligand
       K05454  FLT3LG; fms-related tyrosine kinase 3 ligand
       K05448  VEGFA; vascular endothelial growth factor A
       K16858  VEGFB; vascular endothelial growth factor B
       K16859  PGF; placenta growth factor
       K05449  VEGFC_D; vascular endothelial growth factor C/D
       K05460  HGF; hepatocyte growth factor
       K05465  ANGPT1; angiopoietin 1
       K05466  ANGPT2; angiopoietin 2
       K05467  ANGPT4; angiopoietin 4
       K05462  EFNA; ephrin-A
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K04362  FGFR1, CD331; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K05093  FGFR2, CD332; fibroblast growth factor receptor 2 [EC:2.7.10.1]
       K05094  FGFR3, CD333; fibroblast growth factor receptor 3 [EC:2.7.10.1]
       K05095  FGFR4, CD334; fibroblast growth factor receptor 4 [EC:2.7.10.1]
       K02583  NGFR, CD271; nerve growth factor receptor (TNFR superfamily member 16)
       K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
       K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]
       K04527  INSR, CD220; insulin receptor [EC:2.7.10.1]
       K05087  IGF1R, CD221; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
       K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3 [EC:2.7.10.1]
       K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
       K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
       K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor [EC:2.7.10.1]
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
       K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]
       K05103  EPHA2, ECK; Eph receptor A2 [EC:2.7.10.1]
       K04364  GRB2; growth factor receptor-binding protein 2
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K16172  IRS1; insulin receptor substrate 1
       K10159  TLR2, CD282; toll-like receptor 2
       K10160  TLR4, CD284; toll-like receptor 4
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K06856  IGH; immunoglobulin heavy chain
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K06465  CD19; B-lymphocyte antigen CD19
       K12230  PIK3AP1, BCAP; phosphoinositide 3-kinase adapter protein 1
       K05438  GH; growth hormone
       K05439  PRL; prolactin
       K05418  OSM; oncostatin M
       K05429  IL2; interleukin 2
       K04736  IL3; interleukin 3
       K05405  IL6; interleukin 6
       K05430  IL4; interleukin 4
       K05431  IL7; interleukin 7
       K05414  IFNA; interferon alpha
       K05415  IFNB; interferon beta
       K05437  EPO; erythropoietin
       K05423  CSF3, GCSF; granulocyte colony-stimulating factor
       K05080  GHR; growth hormone receptor
       K05081  PRLR; prolactin receptor
       K05057  OSMR; oncostatin M receptor
       K05068  IL2RA, CD25; interleukin 2 receptor alpha
       K05069  IL2RB, CD122; interleukin 2 receptor beta
       K05070  IL2RG, CD132; interleukin 2 receptor gamma
       K04737  IL3RA, CD123; interleukin 3 receptor alpha
       K05055  IL6R, CD126; interleukin 6 receptor
       K05071  IL4R, CD124; interleukin 4 receptor
       K05072  IL7R, CD127; interleukin 7 receptor
       K05130  IFNAR1; interferon receptor 1
       K05131  IFNAR2; interferon receptor 2
       K05079  EPOR; erythropoietin receptor
       K05061  CSF3R, CD114; granulocyte colony-stimulating factor receptor
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
       K11218  JAK3; Janus kinase 3 [EC:2.7.10.2]
       K06236  COL1A; collagen, type I, alpha
       K19719  COL2A; collagen, type II, alpha
       K06237  COL4A; collagen, type IV, alpha
       K06238  COL6A; collagen, type VI, alpha
       K08131  COL9A; collagen, type IX, alpha
       K05637  LAMA1_2; laminin, alpha 1/2
       K06240  LAMA3_5; laminin, alpha 3/5
       K06241  LAMA4; laminin, alpha 4
       K05636  LAMB1; laminin, beta 1
       K06243  LAMB2; laminin, beta 2
       K06244  LAMB3; laminin, beta 3
       K06245  LAMB4; laminin, beta 4
       K05635  LAMC1; laminin, gamma 1
       K06246  LAMC2; laminin, gamma 2
       K06247  LAMC3; laminin, gamma 3
       K06248  CHAD; chondroadherin
       K06249  RELN; reelin [EC:3.4.21.-]
       K16857  THBS1; thrombospondin 1
       K04659  THBS2S; thrombospondin 2/3/4/5
       K05717  FN1; fibronectin 1
       K06250  SPP1, BNSP, OPN; secreted phosphoprotein 1
       K06251  VTN; vitronectin
       K06252  TN; tenascin
       K03900  VWF; von Willebrand factor
       K06253  IBSP; integrin binding sialoprotein
       K06480  ITGA1, CD49a; integrin alpha 1
       K06481  ITGA2, CD49b; integrin alpha 2
       K06476  ITGA2B, CD41; integrin alpha 2B
       K06482  ITGA3, CD49c; integrin alpha 3
       K06483  ITGA4, CD49d; integrin alpha 4
       K06484  ITGA5, CD49e; integrin alpha 5
       K06485  ITGA6, CD49f; integrin alpha 6
       K06583  ITGA7; integrin alpha 7
       K06584  ITGA8; integrin alpha 8
       K06585  ITGA9; integrin alpha 9
       K06586  ITGA10; integrin alpha 10
       K06587  ITGA11; integrin alpha 11
       K06487  ITGAV, CD51; integrin alpha V
       K05719  ITGB1, CD29; integrin beta 1
       K06493  ITGB3, CD61; integrin beta 3
       K06525  ITGB4, CD104; integrin beta 4
       K06588  ITGB5; integrin beta 5
       K06589  ITGB6; integrin beta 6
       K06590  ITGB7; integrin beta 7
       K06591  ITGB8; integrin beta 8
       K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
       K04129  CHRM1; muscarinic acetylcholine receptor M1
       K04130  CHRM2; muscarinic acetylcholine receptor M2
       K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
       K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
       K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
       K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
       K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
       K04273  LPAR6, P2RY5; lysophosphatidic acid receptor 6
       K04536  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
       K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
       K07825  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
       K04538  GNB4; guanine nucleotide-binding protein subunit beta-4
       K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
       K07826  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
       K04540  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
       K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
       K04542  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
       K04543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
       K04544  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
       K04545  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
       K04546  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K04547  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
       K04548  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
       K04549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
       K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]
       K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
       K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
       K07298  STK11, LKB1; serine/threonine-protein kinase 11 [EC:2.7.11.1]
       K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
       K08270  DDIT4, REDD1; DNA-damage-inducible transcript 4
       K07206  TSC1; tuberous sclerosis 1
       K07207  TSC2; tuberous sclerosis 2
       K07208  RHEB; Ras homolog enriched in brain
       K08266  MLST8, GBL; target of rapamycin complex subunit LST8
       K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
       K07204  RAPTOR; regulatory associated protein of mTOR
       K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
       K03259  EIF4E; translation initiation factor 4E
       K04688  RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
       K03258  EIF4B; translation initiation factor 4B
       K02991  RP-S6e, RPS6; small subunit ribosomal protein S6e
       K02677  PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
       K06071  PKN; protein kinase N [EC:2.7.11.13]
       K13302  SGK1; serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
       K13303  SGK2; serum/glucocorticoid-regulated kinase 2 [EC:2.7.11.1]
       K13304  SGK3; serum/glucocorticoid-regulated kinase 3 [EC:2.7.11.1]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
       K16339  THEM4, CTMP; thioesterase superfamily member 4
       K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
       K03456  PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
       K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
       K11583  PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
       K11584  PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
       K04079  HSP90A, htpG; molecular chaperone HtpG
       K09487  HSP90B, TRA1; heat shock protein 90kDa beta
       K09554  CDC37; cell division cycle protein 37
       K16333  CRTC2, TORC2; CREB-regulated transcription coactivator 2
       K16340  PHLPP; PH domain and leucine-rich repeat-containing protein phosphatase [EC:3.1.3.16]
       K10167  TCL1A; T-cell leukemia/lymphoma 1A
       K16836  TCL1B; T-cell leukemia/lymphoma 1B
       K16837  MTCP1; mature T-cell proliferation-1 type B1
       K13242  NOS3; nitric-oxide synthase, endothelial [EC:1.14.13.39]
       K10605  BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K00693  GYS; glycogen synthase [EC:2.4.1.11]
       K01596  E4.1.1.32, pckA, PCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
       K01084  G6PC; glucose-6-phosphatase [EC:3.1.3.9]
       K04377  MYC; Myc proto-oncogene protein
       K04503  CCND1; G1/S-specific cyclin-D1
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K10151  CCND2; G1/S-specific cyclin-D2
       K10152  CCND3; G1/S-specific cyclin-D3
       K06626  CCNE; G1/S-specific cyclin-E1
       K09408  FOXO3; forkhead box protein O3
       K16332  RBL2; retinoblastoma-like protein 2
       K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
       K16341  BCL2L11, BIM; Bcl-2-like protein 11
       K16197  YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
       K06630  YWHAE; 14-3-3 protein epsilon
       K16198  YWHAG_H; 14-3-3 protein gamma/eta
       K02158  BAD; Bcl-2-antagonist of cell death
       K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
       K02161  BCL2; apoptosis regulator Bcl-2
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1
       K08524  RXRA, NR2B1; retinoid X receptor alpha
       K04465  NR4A1, HMR; nuclear receptor subfamily 4 group A member 1
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K04735  RELA; transcription factor p65
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K09420  MYB, C-MYB; transcriptional activator Myb
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
       K04451  TP53, P53; tumor protein p53
     04152 AMPK signaling pathway [PATH:ko04152]
     04150 mTOR signaling pathway [PATH:ko04150]
     04075 Plant hormone signal transduction [PATH:ko04075]
 
   Signaling molecules and interaction
 
 Cellular Processes
 
 Organismal Systems
 
 Human Diseases
 
   Cancers
 
   Immune diseases
 
   Neurodegenerative diseases
 
   Substance dependence
 
   Cardiovascular diseases
 
   Endocrine and metabolic diseases
 
   Infectious diseases
     05110 Vibrio cholerae infection [PATH:ko05110]
     05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
     05130 Pathogenic Escherichia coli infection [PATH:ko05130]
     05132 Salmonella infection [PATH:ko05132]
     05131 Shigellosis [PATH:ko05131]
     05133 Pertussis [PATH:ko05133]
     05134 Legionellosis [PATH:ko05134]
     05150 Staphylococcus aureus infection [PATH:ko05150]
     05152 Tuberculosis [PATH:ko05152]
     05100 Bacterial invasion of epithelial cells [PATH:ko05100]
     05166 HTLV-I infection [PATH:ko05166]
     05162 Measles [PATH:ko05162]
     05164 Influenza A [PATH:ko05164]
     05161 Hepatitis B [PATH:ko05161]
     05160 Hepatitis C [PATH:ko05160]
     05168 Herpes simplex infection [PATH:ko05168]
     05167 Kaposi's sarcoma-associated herpesvirus infection [PATH:ko05167]
       K21649  ORF4; complement control protein
       K03990  C3; complement component 3
       K05401  TLR3, CD283; toll-like receptor 3
       K05842  TRIF; toll-like receptor adapter molecule 1
       K03174  TRAF3; TNF receptor-associated factor 3
       K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
       K05410  TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
       K09447  IRF7; interferon regulatory factor 7
       K21650  KIE1, ORF50; KSHV transcription activator ORF50
       K21859  KIE2, ORF45; KSHV transcription activator ORF45
       K21652  vIRF3; KSHV interferon regulatory factor-like protein 3
       K05414  IFNA; interferon alpha
       K05411  IRF3; interferon regulatory factor 3
       K21653  vIRF1, K9; KSHV interferon regulatory factor-like protein 1
       K21654  vIRF2, K11; KSHV interferon regulatory factor-like protein 2
       K21655  K8; KSHV E3 SUMO-protein ligase K-bZIP
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K05415  IFNB; interferon beta
       K05130  IFNAR1; interferon receptor 1
       K05131  IFNAR2; interferon receptor 2
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K11219  TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
       K11220  STAT1; signal transducer and activator of transcription 1
       K11221  STAT2; signal transducer and activator of transcription 2
       K04693  IRF9, ISGF3G, P48; interferon regulatory factor 9
       K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
       K21656  K12; protein K12
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
       K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
       K15308  TTP; tristetraprolin
       K05405  IL6; interleukin 6
       K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
       K21657  K4; viral macrophage inflammatory protein 2
       K04178  CCR3, CD193; C-C chemokine receptor type 3
       K04180  CCR5, CD195; C-C chemokine receptor type 5
       K04176  CCR1, CD191; C-C chemokine receptor type 1
       K21658  K4.1; protein vCCL3
       K04179  CCR4, CD194; C-C chemokine receptor type 4
       K21659  K6; protein K6
       K04183  CCR8, CDw198; C-C chemokine receptor type 8
       K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K04726  BID; BH3 interacting domain death agonist
       K21660  vBCL2, ORF16; KSHV apoptosis regulator BCL2 homolog
       K02159  BAX; apoptosis regulator BAX
       K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
       K08738  CYC; cytochrome c
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K21661  vIAP, K7; KSHV inhibitor of apoptosis protein
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
       K21662  vFLIP, K13, ORF71; KSHV FLICE inhibitory protein
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K21651  K15; signal transducing membrane protein
       K04451  TP53, P53; tumor protein p53
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K21663  vCyclin, ORF72; KSHV cyclin homolog
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K06618  RB1; retinoblastoma-associated protein
       K17454  E2F1; transcription factor E2F1
       K09389  E2F2; transcription factor E2F2
       K06620  E2F3; transcription factor E2F3
       K21664  vLANA, ORF73; KSHV latency-associated nuclear antigen
       K06751  MHC1; major histocompatibility complex, class I
       K21665  MIR1, K3; KSHV E3 ubiquitin-protein ligase MIR1 [EC:2.3.2.27]
       K21666  MIR2, K5; KSHV E3 ubiquitin-protein ligase MIR2 [EC:2.3.2.27]
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K06490  ICAM1, CD54; intercellular adhesion molecule 1
       K05413  CD86; CD86 antigen
       K07985  MIC; MHC class I-related protein
       K10071  CLEC2B; C-type lectin domain family 2 member B
       K04551  UBB; ubiquitin B
       K08334  BECN, VPS30, ATG6; beclin
       K17889  ATG14L, ATG14; beclin 1-associated autophagy-related key regulator
       K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
       K08343  ATG3; ubiquitin-like-conjugating enzyme ATG3
       K08341  GABARAP, ATG8, LC3; GABA(A) receptor-associated protein
       K21667  vGPCR; viral G-protein coupled receptor
       K04536  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
       K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
       K07825  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
       K04538  GNB4; guanine nucleotide-binding protein subunit beta-4
       K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
       K07826  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
       K04540  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
       K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
       K04542  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
       K04543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
       K04544  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
       K04545  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
       K04546  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K04547  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
       K04548  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
       K04549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K08268  HIF1A; hypoxia-inducible factor 1 alpha
       K04448  JUN; transcription factor AP-1
       K04379  FOS; proto-oncogene protein c-fos
       K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]
       K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
       K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
       K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
       K12365  PREX1; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger 1 protein
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K21668  CD200R1; cell surface glycoprotein CD200 receptor 1
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K21669  K1; protein K1
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K08893  HCK; hemopoietic cell kinase [EC:2.7.10.2]
       K05854  LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
       K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
       K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K02183  CALM; calmodulin
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
       K17332  NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2
       K17333  NFATC3, NFAT4; nuclear factor of activated T-cells, cytoplasmic 3
       K17334  NFATC4, NFAT3; nuclear factor of activated T-cells, cytoplasmic 4
       K10030  IL8, CXCL8; interleukin 8
       K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
       K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
       K17901  RCAN1, MCIP1; calcipressin-1
       K18497  FGF2; fibroblast growth factor 2
       K05448  VEGFA; vascular endothelial growth factor A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K21670  K2; viral interleukin-6
       K05466  ANGPT2; angiopoietin 2
       K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
       K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
       K04692  STAT3; signal transducer and activator of transcription 3
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K02105  CTNNB1; catenin beta 1
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04503  CCND1; G1/S-specific cyclin-D1
       K04377  MYC; Myc proto-oncogene protein
     05169 Epstein-Barr virus infection [PATH:ko05169]
     05165 Human papillomavirus infection [PATH:ko05165]
     05146 Amoebiasis [PATH:ko05146]
     05144 Malaria [PATH:ko05144]
     05145 Toxoplasmosis [PATH:ko05145]
     05140 Leishmaniasis [PATH:ko05140]
     05142 Chagas disease (American trypanosomiasis) [PATH:ko05142]
     05143 African trypanosomiasis [PATH:ko05143]
 
   Drug resistance

[ KO | BRITE | KEGG2 | KEGG ]
Last updated: November 18, 2017