KEGG Orthology (KO)

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 Metabolism
 
 Genetic Information Processing
 
 Environmental Information Processing
 
   Membrane transport
 
   Signal transduction
     02020 Two-component system [PATH:ko02020]
     02022 Two-component system [BR:ko02022]
     04014 Ras signaling pathway [PATH:ko04014]
     04015 Rap1 signaling pathway [PATH:ko04015]
       K04353  RAP1A; Ras-related protein Rap-1A
       K07836  RAP1B; Ras-related protein Rap-1B
       K07831  MRAS; Ras-related protein M-Ras
       K08019  RAPGEF5; Rap guanine nucleotide exchange factor 5
       K17697  DOCK4; dedicator of cytokinesis protein 4
       K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
       K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
       K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
       K02183  CALM; calmodulin
       K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
       K04236  F2RL3, PAR4; coagulation factor II (thrombin) receptor-like 3
       K04270  P2RY1; purinergic receptor P2Y, G protein-coupled, 1
       K04172  FPR1; formyl peptide receptor 1
       K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
       K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
       K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
       K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
       K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
       K04266  ADORA2A, ADOR; adenosine receptor A2a
       K04267  ADORA2B; adenosine receptor A2b
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
       K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K12362  RASGRP3; RAS guanyl-releasing protein 3
       K12361  RASGRP2; RAS guanyl-releasing protein 2
       K04357  EGF; epidermal growth factor
       K04358  FGF; fibroblast growth factor
       K05451  NGFA; nerve growth factor, alpha
       K02582  NGFB; nerve growth factor, beta
       K04526  INS; insulin
       K05459  IGF1; insulin-like growth factor 1
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K05450  PDGFC_D; platelet derived growth factor C/D
       K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
       K05461  KITLG; KIT ligand
       K05448  VEGFA; vascular endothelial growth factor A
       K16858  VEGFB; vascular endothelial growth factor B
       K16859  PGF; placenta growth factor
       K05449  VEGFC_D; vascular endothelial growth factor C/D
       K05460  HGF; hepatocyte growth factor
       K05465  ANGPT1; angiopoietin 1
       K05466  ANGPT2; angiopoietin 2
       K05467  ANGPT4; angiopoietin 4
       K05462  EFNA; ephrin-A
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K04362  FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K05093  FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
       K05094  FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
       K05095  FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
       K02583  NGFR; nerve growth factor receptor (TNFR superfamily member 16)
       K04527  INSR; insulin receptor [EC:2.7.10.1]
       K05087  IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K04363  PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K05090  CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
       K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
       K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
       K05098  KDR, VEGFR2; kinase insert domain protein receptor [EC:2.7.10.1]
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
       K05121  TEK, TIE2; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]
       K05103  EPHA2, ECK; Eph receptor A2 [EC:2.7.10.1]
       K04438  CRK, CRKII; proto-oncogene C-crk
       K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
       K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
       K05689  CDHE, CDH1; cadherin 1, type 1, E-cadherin
       K02105  CTNNB1; catenin beta 1
       K05631  AIP3, WWP3, BAIAP1; atrophin-1 interacting protein 3 (BAI1-associated protein 1)
       K05629  AIP1; atrophin-1 interacting protein 1
       K06112  MAGI3; membrane-associated guanylate kinase-related
       K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2
       K08020  RAPGEF6, PDZGEF2; Rap guanine nucleotide exchange factor 6
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K07362  LAT; linker for activation of T cells
       K17698  FYB, ADAP; FYN binding protein
       K07361  LCP2; lymphocyte cytosolic protein 2
       K17699  SKAP1, SKAP55; src kinase associated phosphoprotein 1
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
       K06070  PKD; protein kinase D [EC:2.7.11.13]
       K04145  DRD2; dopamine receptor D2
       K04277  CNR1; cannabinoid receptor 1
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
       K17700  RAP1GAP, RAPGAP; RAP1 GTPase activating protein 1
       K17701  SIPA1L1, E6TP1; signal-induced proliferation-associated 1 like protein 1
       K08013  SIPA1; signal-induced proliferation-associated gene 1
       K17702  SIPA1L2, SPAL2; signal-induced proliferation-associated 1 like protein 2
       K17703  SIPA1L3, SPAL3; signal-induced proliferation-associated 1 like protein 3
       K04680  ID1; DNA-binding protein inhibitor ID1
       K16857  THBS1; thrombospondin 1
       K08732  RALGDS; ral guanine nucleotide dissociation stimulator
       K07834  RALA; Ras-related protein Ral-A
       K07835  RALB; Ras-related protein Ral-B
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K17704  APBB1IP, RIAM; amyloid beta A4 precursor protein-binding family B member 1-interacting protein
       K06271  TLN; talin
       K06476  ITGA2B; integrin alpha 2B
       K06493  ITGB3; integrin beta 3
       K05759  PFN; profilin
       K06274  VASP; vasodilator-stimulated phosphoprotein
       K05692  ACTB_G1; actin beta/gamma 1
       K12490  ARAP3; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
       K04513  RHOA; Ras homolog gene family, member A
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K06082  FARP2, FRG; FERM, RhoGEF and pleckstrin domain protein 2
       K04393  CDC42; cell division control protein 42
       K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
       K04237  PARD3; partitioning defective protein 3
       K06093  PARD6; partitioning defective protein 6
       K06069  APKC; atypical protein kinase C [EC:2.7.11.13]
       K05702  AF6, MLLT4; afadin
       K05690  CTNND1; catenin (cadherin-associated protein), delta 1
       K17705  KRIT1; Krev interaction trapped protein 1
       K17706  RGS14; regulator of G-protein signaling 14
       K08015  RASSF5, RAPL; Ras association domain-containing protein 5
       K05718  ITGAL; integrin alpha L
       K06461  ITGAM; integrin alpha M
       K06464  ITGB2; integrin beta 2
       K05719  ITGB1; integrin beta 1
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
       K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K05860  PLCE; phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K07829  RRAS; Ras-related protein R-Ras
     04010 MAPK signaling pathway [PATH:ko04010]
     04013 MAPK signaling pathway - fly [PATH:ko04013]
     04011 MAPK signaling pathway - yeast [PATH:ko04011]
     04012 ErbB signaling pathway [PATH:ko04012]
     04310 Wnt signaling pathway [PATH:ko04310]
     04330 Notch signaling pathway [PATH:ko04330]
     04340 Hedgehog signaling pathway [PATH:ko04340]
     04350 TGF-beta signaling pathway [PATH:ko04350]
     04390 Hippo signaling pathway [PATH:ko04390]
     04391 Hippo signaling pathway -fly [PATH:ko04391]
     04370 VEGF signaling pathway [PATH:ko04370]
     04630 Jak-STAT signaling pathway [PATH:ko04630]
     04064 NF-kappa B signaling pathway [PATH:ko04064]
     04668 TNF signaling pathway [PATH:ko04668]
     04066 HIF-1 signaling pathway [PATH:ko04066]
     04068 FoxO signaling pathway [PATH:ko04068]
     04020 Calcium signaling pathway [PATH:ko04020]
     04070 Phosphatidylinositol signaling system [PATH:ko04070]
     04022 cGMP - PKG signaling pathway [PATH:ko04022]
     04151 PI3K-Akt signaling pathway [PATH:ko04151]
     04152 AMPK signaling pathway [PATH:ko04152]
     04150 mTOR signaling pathway [PATH:ko04150]
     04075 Plant hormone signal transduction [PATH:ko04075]
 
   Signaling molecules and interaction
 
 Cellular Processes
 
   Transport and catabolism
 
   Cell motility
     02030 Bacterial chemotaxis [PATH:ko02030]
     02035 Bacterial motility proteins [BR:ko02035]
     02040 Flagellar assembly [PATH:ko02040]
     04810 Regulation of actin cytoskeleton [PATH:ko04810]
       K01313  F2; coagulation factor II (thrombin) [EC:3.4.21.5]
       K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
       K04391  CD14; CD14 antigen
       K04526  INS; insulin
       K04357  EGF; epidermal growth factor
       K04358  FGF; fibroblast growth factor
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K05450  PDGFC_D; platelet derived growth factor C/D
       K05086  INSRR; insulin receptor-related receptor [EC:2.7.10.1]
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K04362  FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K05093  FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
       K05094  FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
       K05095  FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
       K04363  PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K05717  FN1; fibronectin 1
       K06480  ITGA1; integrin alpha 1
       K06481  ITGA2; integrin alpha 2
       K06476  ITGA2B; integrin alpha 2B
       K06482  ITGA3; integrin alpha 3
       K06483  ITGA4; integrin alpha 4
       K06484  ITGA5; integrin alpha 5
       K06485  ITGA6; integrin alpha 6
       K06583  ITGA7; integrin alpha 7
       K06584  ITGA8; integrin alpha 8
       K06585  ITGA9; integrin alpha 9
       K06586  ITGA10; integrin alpha 10
       K06587  ITGA11; integrin alpha 11
       K06487  ITGAV; integrin alpha V
       K05718  ITGAL; integrin alpha L
       K06461  ITGAM; integrin alpha M
       K06462  ITGAX; integrin alpha X
       K06594  ITGAD; integrin alpha D
       K06524  ITGAE; integrin alpha E
       K05719  ITGB1; integrin beta 1
       K06464  ITGB2; integrin beta 2
       K06493  ITGB3; integrin beta 3
       K06525  ITGB4; integrin beta 4
       K06588  ITGB5; integrin beta 5
       K06589  ITGB6; integrin beta 6
       K06590  ITGB7; integrin beta 7
       K06591  ITGB8; integrin beta 8
       K03915  BDKRB1; bradykinin receptor B1
       K03916  BDKRB2; bradykinin receptor B2
       K04129  CHRM1; muscarinic acetylcholine receptor M1
       K04130  CHRM2; muscarinic acetylcholine receptor M2
       K04131  CHRM3; muscarinic acetylcholine receptor M3
       K04132  CHRM4; muscarinic acetylcholine receptor M4
       K04133  CHRM5; muscarinic acetylcholine receptor M5
       K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
       K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K05720  FGD1; FYVE, RhoGEF and PH domain containing 1
       K05722  FGD3; FYVE, RhoGEF and PH domain containing 3
       K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
       K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
       K04438  CRK, CRKII; proto-oncogene C-crk
       K13708  DOCK1; dedicator of cytokinesis protein 1
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K07829  RRAS; Ras-related protein R-Ras
       K07830  RRAS2, TC21; Ras-related protein R-Ras2
       K07831  MRAS; Ras-related protein M-Ras
       K05729  ARHGEF6, PIXA; Rho guanine nucleotide exchange factor 6
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K05730  VAV; guanine nucleotide exchange factor VAV
       K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04367  MOS; proto-oncogene serine/threonine-protein kinase mos [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
       K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
       K05732  GRLF1; glucocorticoid receptor DNA-binding factor 1
       K04513  RHOA; Ras homolog gene family, member A
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K04393  CDC42; cell division control protein 42
       K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
       K04410  PAK2; p21-activated kinase 2 [EC:2.7.11.1]
       K05733  PAK3, MRX30; p21-activated kinase 3 [EC:2.7.11.1]
       K05734  PAK4; p21-activated kinase 4 [EC:2.7.11.1]
       K05735  PAK6; p21-activated kinase 6 [EC:2.7.11.1]
       K05736  PAK7; p21-activated kinase 7 [EC:2.7.11.1]
       K13710  ARHGEF7, PIXB; Rho guanine nucleotide exchange factor 7
       K05737  GIT1; G protein-coupled receptor kinase interactor 1
       K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
       K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
       K00907  MYLK; myosin-light-chain kinase [EC:2.7.11.18]
       K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
       K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
       K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
       K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
       K10351  MYL2; myosin regulatory light chain 2
       K12753  MYL5; myosin regulatory light chain 5
       K12754  MYL7; myosin regulatory light chain 7
       K12755  MYL9; myosin regulatory light chain 9
       K12756  MYL10; myosin regulatory light chain 10
       K12757  MYL12; myosin regulatory light chain 12
       K12758  MYLPF; fast skeletal myosin light chain 2
       K05740  DIAPH1; diaphanous 1
       K05741  DIAPH2; diaphanous 2
       K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
       K00889  E2.7.1.68, PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
       K00920  E2.7.1.149, PIP4K; 1-phosphatidylinositol-5-phosphate 4-kinase [EC:2.7.1.149]
       K00921  PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
       K05743  LIMK1; LIM domain kinase 1 [EC:2.7.11.1]
       K05744  LIMK2; LIM domain kinase 2 [EC:2.7.11.1]
       K05745  DIAPH3, DRF3; diaphanous 3
       K05627  BAIAP2, IRSP53; BAI1-associated protein 2
       K05746  ENAH, MENA; enabled
       K05747  WAS; Wiskott-Aldrich syndrome protein
       K05748  WASF2; WAS protein family, member 2
       K05749  CYFIP; cytoplasmic FMR1 interacting protein
       K05750  NCKAP1, NAP125; NCK-associated protein 1
       K05751  ABI2; abl interactor 2
       K05752  C3ORF10, HSPC300; chromosome 3 open reading frame 10
       K05753  WASF1; WAS protein family, member 1
       K05754  ARPC5; actin related protein 2/3 complex, subunit 5
       K05755  ARPC4; actin related protein 2/3 complex, subunit 4
       K05756  ARPC3; actin related protein 2/3 complex, subunit 3
       K05757  ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
       K05758  ARPC2; actin related protein 2/3 complex, subunit 2
       K05692  ACTB_G1; actin beta/gamma 1
       K05759  PFN; profilin
       K05760  PXN; paxillin
       K08007  VIL2; villin 2 (ezrin)
       K05762  RDX; radixin
       K05763  MSN; moesin
       K05764  TMSB4; thymosin, beta 4
       K05765  CFL; cofilin
       K05766  SSH; protein phosphatase slingshot [EC:3.1.3.16 3.1.3.48]
       K05700  VCL; vinculin
       K16848  IQGAP1; Ras GTPase-activating-like protein IQGAP1
       K05767  IQGAP2_3; Ras GTPase-activating-like protein IQGAP2/3
       K05768  GSN; gelsolin
       K05699  ACTN; actinin alpha
       K02085  APC; adenomatosis polyposis coli protein
       K05769  ARHGEF4, ASEF; Rho guanine nucleotide exchange factor 4
     04812 Cytoskeleton proteins [BR:ko04812]
 
   Cell growth and death
 
   Cell communication
 
 Organismal Systems
 
 Human Diseases
 
   Cancers
 
   Immune diseases
 
   Neurodegenerative diseases
 
   Substance dependence
 
   Cardiovascular diseases
 
   Endocrine and metabolic diseases
 
   Infectious diseases
     05110 Vibrio cholerae infection [PATH:ko05110]
     05111 Vibrio cholerae pathogenic cycle [PATH:ko05111]
     05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
     05130 Pathogenic Escherichia coli infection [PATH:ko05130]
     05132 Salmonella infection [PATH:ko05132]
       K04391  CD14; CD14 antigen
       K10160  TLR4; toll-like receptor 4
       K05399  LBP; lipopolysaccharide-binding protein
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K13285  sipB, ipaB, bipB; invasin B
       K13286  sipC, ipaC, bipC; invasin C
       K13287  sipD, ipaD, bipD; invasin D
       K02406  fliC; flagellin
       K10168  TLR5; toll-like receptor 5
       K12805  NLRC4, CARD12; NLR family CARD domain-containing protein 4
       K12799  PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD
       K01370  CASP1; caspase 1 [EC:3.4.22.36]
       K13741  sopE; guanine nucleotide exchange factor SopE
       K13085  ipgD, sopB; phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78]
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K04393  CDC42; cell division control protein 42
       K07863  RHOG; Ras homolog gene family, member G
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K04379  FOS; proto-oncogene protein c-fos
       K04448  JUN; transcription factor AP-1
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K05482  IL18, IL1F4; interleukin 18
       K04519  IL1B; interleukin 1 beta
       K04383  IL1A; interleukin 1 alpha
       K05405  IL6; interleukin 6
       K10030  IL8, CXCL8; interleukin 8
       K05408  CCL3; C-C motif chemokine 3
       K12964  CCL4; C-C motif chemokine 4
       K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
       K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
       K05753  WASF1; WAS protein family, member 1
       K05748  WASF2; WAS protein family, member 2
       K05747  WAS; Wiskott-Aldrich syndrome protein
       K05754  ARPC5; actin related protein 2/3 complex, subunit 5
       K05755  ARPC4; actin related protein 2/3 complex, subunit 4
       K05756  ARPC3; actin related protein 2/3 complex, subunit 3
       K05757  ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
       K05758  ARPC2; actin related protein 2/3 complex, subunit 2
       K05701  TJP1, ZO1; tight junction protein 1
       K05692  ACTB_G1; actin beta/gamma 1
       K13284  sipA, ipaA; invasin A
       K13740  sptP; secreted effector protein SptP
       K08598  yopJ; YopJ protease family
       K15343  sspH1; E3 ubiquitin-protein ligase SspH1 [EC:6.3.2.19]
       K06071  PKN; protein kinase N [EC:2.7.11.13]
       K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
       K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
       K15344  sseB; secreted effector protein SseB
       K15345  sseC; secreted effector protein SseC
       K15346  sseD; secreted effector protein SseD
       K15347  sifA; secreted effector protein SifA
       K15348  PLEKHM2, SKIP; pleckstrin homology domain-containing family M member 2
       K10407  KLC; kinesin light chain
       K07897  RAB7A; Ras-related protein Rab-7A
       K07898  RAB7B; Ras-related protein Rab-7B
       K13883  RILP; Rab-interacting lysosomal protein
       K15349  sseJ; secreted effector protein SseJ
       K15350  sseF; secreted effector protein SseF
       K15351  sseG; secreted effector protein SseG
       K10413  DYNC1H; dynein heavy chain 1, cytosolic
       K10414  DYNC2H, DNCH2; dynein heavy chain 2, cytosolic
       K10415  DYNC1I, DNCI; dynein intermediate chain, cytosolic
       K10416  DYNC1LI, DNCLI; dynein light intermediate chain 1, cytosolic
       K15352  pipB2; secreted effector protein PipB2
       K15353  sspH2; E3 ubiquitin-protein ligase SspH2 [EC:6.3.2.19]
       K15354  sseI, srfH; secreted effector protein SseI
       K05759  PFN; profilin
       K04437  FLNA; filamin
       K15366  spvB; salmonella plasmid virulence protein B
       K04687  IFNG; interferon gamma
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
       K12266  norR; anaerobic nitric oxide reductase transcription regulator
       K12264  norV; anaerobic nitric oxide reductase flavorubredoxin
       K12265  norW; nitric oxide reductase FlRd-NAD(+) reductase [EC:1.18.1.-]
       K13771  nsrR; Rrf2 family transcriptional regulator, nitric oxide-sensitive transcriptional repressor
       K05916  hmp, YHB1; nitric oxide dioxygenase [EC:1.14.12.17]
       K03385  nrfA; nitrite reductase (cytochrome c-552) [EC:1.7.2.2]
     05131 Shigellosis [PATH:ko05131]
       K13287  sipD, ipaD, bipD; invasin D
       K13286  sipC, ipaC, bipC; invasin C
       K13285  sipB, ipaB, bipB; invasin B
       K06484  ITGA5; integrin alpha 5
       K05719  ITGB1; integrin beta 1
       K06256  CD44; CD44 antigen
       K13742  ipgB1; protein IpgB1
       K07863  RHOG; Ras homolog gene family, member G
       K12366  ELMO1, CED12; engulfment and cell motility protein 1
       K13708  DOCK1; dedicator of cytokinesis protein 1
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K05753  WASF1; WAS protein family, member 1
       K05748  WASF2; WAS protein family, member 2
       K05754  ARPC5; actin related protein 2/3 complex, subunit 5
       K05755  ARPC4; actin related protein 2/3 complex, subunit 4
       K05756  ARPC3; actin related protein 2/3 complex, subunit 3
       K05757  ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
       K05758  ARPC2; actin related protein 2/3 complex, subunit 2
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K06106  CTTN, EMS1; cortactin
       K06619  ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
       K04438  CRK, CRKII; proto-oncogene C-crk
       K04393  CDC42; cell division control protein 42
       K12785  espG, virA; LEE-encoded effector EspG
       K13284  sipA, ipaA; invasin A
       K05700  VCL; vinculin
       K13085  ipgD, sopB; phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78]
       K13743  ipgB2; protein IpgB2
       K05740  DIAPH1; diaphanous 1
       K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
       K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
       K12679  icsA, virG; outer membrane protein IcsA
       K13790  icsB, bopA; virulence protein IcsB
       K05747  WAS; Wiskott-Aldrich syndrome protein
       K05692  ACTB_G1; actin beta/gamma 1
       K05759  PFN; profilin
       K08339  ATG5; autophagy-related protein 5
       K08727  NOD1, CARD4; nucleotide-binding oligomerization domain-containing protein 1
       K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
       K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K02581  NFKBIB; NF-kappa-B inhibitor beta
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K10030  IL8, CXCL8; interleukin 8
       K13450  ospF, mkaD; phosphothreonine lyase [EC:4.2.3.-]
       K13791  ipaH9.8; invasion plasmid antigen
       K12836  U2AF1; splicing factor U2AF 35 kDa subunit
       K13792  ospG; secreted effector OspG
       K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
       K13728  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B
       K13793  ospE, espO; secreted effector OspE
       K11006  stxA; shiga toxin subunit A
       K11007  stxB; shiga toxin subunit B
       K11011  set1A; enterotoxin Set1A
       K11012  set1B; enterotoxin Set1B
     05133 Pertussis [PATH:ko05133]
     05134 Legionellosis [PATH:ko05134]
     05150 Staphylococcus aureus infection [PATH:ko05150]
     05152 Tuberculosis [PATH:ko05152]
     05100 Bacterial invasion of epithelial cells [PATH:ko05100]
     05166 HTLV-I infection [PATH:ko05166]
     05162 Measles [PATH:ko05162]
     05164 Influenza A [PATH:ko05164]
     05161 Hepatitis B [PATH:ko05161]
     05160 Hepatitis C [PATH:ko05160]
     05168 Herpes simplex infection [PATH:ko05168]
     05169 Epstein-Barr virus infection [PATH:ko05169]
     05146 Amoebiasis [PATH:ko05146]
     05144 Malaria [PATH:ko05144]
     05145 Toxoplasmosis [PATH:ko05145]
     05140 Leishmaniasis [PATH:ko05140]
     05142 Chagas disease (American trypanosomiasis) [PATH:ko05142]
     05143 African trypanosomiasis [PATH:ko05143]
 
   Drug resistance

[ BRITE | KEGG2 | KEGG ]
Last updated: July 22, 2014