KEGG Orthology (KO)

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 Metabolism
 
 Genetic Information Processing
 
 Environmental Information Processing
 
   Membrane transport
 
   Signal transduction
     02020 Two-component system [PATH:ko02020]
     02022 Two-component system [BR:ko02022]
     04014 Ras signaling pathway [PATH:ko04014]
     04015 Rap1 signaling pathway [PATH:ko04015]
     04010 MAPK signaling pathway [PATH:ko04010]
     04013 MAPK signaling pathway - fly [PATH:ko04013]
     04011 MAPK signaling pathway - yeast [PATH:ko04011]
     04012 ErbB signaling pathway [PATH:ko04012]
     04310 Wnt signaling pathway [PATH:ko04310]
     04330 Notch signaling pathway [PATH:ko04330]
     04340 Hedgehog signaling pathway [PATH:ko04340]
     04350 TGF-beta signaling pathway [PATH:ko04350]
     04390 Hippo signaling pathway [PATH:ko04390]
     04391 Hippo signaling pathway -fly [PATH:ko04391]
     04370 VEGF signaling pathway [PATH:ko04370]
     04630 Jak-STAT signaling pathway [PATH:ko04630]
     04064 NF-kappa B signaling pathway [PATH:ko04064]
     04668 TNF signaling pathway [PATH:ko04668]
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K03158  TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
       K09558  BAG4; BCL2-associated athanogene 4
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K03173  TRAF2; TNF receptor-associated factor 2
       K09849  TRAF5; TNF receptor-associated factor 5
       K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
       K16060  BIRC2_3; baculoviral IAP repeat-containing protein 2/3
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K04403  MAP3K7IP1, TAB1; TAK1-binding protein 1
       K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
       K12793  MAP3K7IP3, TAB3; TAK1-binding protein 3
       K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
       K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K04448  JUN; transcription factor AP-1
       K05632  AIP4, ITCH; atrophin-1 interacting protein 4 [EC:6.3.2.19]
       K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
       K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
       K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K10048  CEBPB; CCAAT/enhancer binding protein (C/EBP), beta
       K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
       K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K04735  RELA; transcription factor p65
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04415  MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8 [EC:2.7.11.25]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04445  MSK1, RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
       K16510  MSK2, RPS6KA4; ribosomal protein S6 kinase alpha-4 [EC:2.7.11.1]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [EC:2.7.11.1]
       K08849  MLKL; mixed lineage kinase domain-like [EC:2.7.11.1]
       K15637  PGAM5; serine/threonine-protein phosphatase PGAM5 [EC:3.1.3.16]
       K17065  DNM1L; dynamin 1-like protein [EC:3.6.5.5]
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K04400  CASP10; caspase 10 [EC:3.4.22.63]
       K04397  CASP7; caspase 7 [EC:3.4.22.60]
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K14624  CCL2, MCP1; C-C motif chemokine 2
       K12499  CCL5; C-C motif chemokine 5
       K14625  CCL20; C-C motif chemokine 20
       K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
       K12671  CXCL10, IP10; C-X-C motif chemokine 10
       K05508  CX3CL1, NTT; C-X3-C motif chemokine 1
       K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
       K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
       K04390  TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
       K05173  IL18R1, IL1RRP; interleukin 18 receptor 1
       K04519  IL1B; interleukin 1 beta
       K05405  IL6; interleukin 6
       K05433  IL15; interleukin 15
       K05419  LIF; leukemia inhibitory factor
       K05468  LTA, TNFB; lymphotoxin alpha (TNF superfamily, member 1)
       K09258  BCL3; B-cell CLL/lymphoma protein 3
       K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
       K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3 [EC:3.4.19.12 6.3.2.19]
       K03172  TRAF1; TNF receptor-associated factor 1
       K17072  IFI47; interferon gamma inducible protein 47
       K04379  FOS; proto-oncogene protein c-fos
       K09028  JUNB; transcription factor jun-B
       K01394  MMP3; matrix metalloproteinase-3 (stromelysin 1, progelatinase) [EC:3.4.24.17]
       K01403  MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
       K07763  MMP14; matrix metalloproteinase-14 (membrane-inserted) [EC:3.4.24.80]
       K16366  EDN1; endothelin-1
       K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
       K06490  ICAM1; intercellular adhesion molecule 1
       K06494  SELE; selectin, endothelial cell
       K06527  VCAM1; vascular cell adhesion molecule 1
       K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
       K05141  TNFRSF1B, TNFR2; tumor necrosis factor receptor superfamily member 1B
       K03174  TRAF3; TNF receptor-associated factor 3
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K05629  AIP1; atrophin-1 interacting protein 1
     04066 HIF-1 signaling pathway [PATH:ko04066]
     04068 FoxO signaling pathway [PATH:ko04068]
     04020 Calcium signaling pathway [PATH:ko04020]
     04070 Phosphatidylinositol signaling system [PATH:ko04070]
     04024 cAMP signaling pathway [PATH:ko04024]
       K05250  FSH; follicle stimulating hormone
       K04141  ADRB1; adrenergic receptor beta-1
       K04144  DRD1; dopamine receptor D1
       K05840  DRD5; dopamine receptor D5
       K04266  ADORA2A, ADOR; adenosine receptor A2a
       K04160  HTR4; 5-hydroxytryptamine receptor 4
       K04162  HTR6; 5-hydroxytryptamine receptor 6
       K04259  PTGER2; prostaglandin E receptor 2
       K04587  ADCYAP1R1, PACAPRI; pituitary adenylate cyclase-activating polypeptide type I receptor
       K04590  VIPR2; vasoactive intestinal peptide receptor 2
       K04249  TSHR; thyroid stimulating hormone receptor
       K04200  MC2R; melanocortin 2 receptor
       K04581  GLP1R; glucagon-like peptide 1 receptor
       K04580  GIPR; gastric inhibitory polypeptide receptor
       K08424  GPR119; G protein-coupled receptor 119
       K04247  FSHR; follicle stimulating hormone receptor
       K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A [EC:4.6.1.2]
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K05232  NPY; neuropeptide Y
       K05254  GHRL; ghrelin
       K04142  ADRB2; adrenergic receptor beta-2
       K04153  HTR1; 5-hydroxytryptamine receptor 1
       K04129  CHRM1; muscarinic acetylcholine receptor M1
       K04130  CHRM2; muscarinic acetylcholine receptor M2
       K04145  DRD2; dopamine receptor D2
       K04615  GABBR; gamma-aminobutyric acid type B receptor
       K04265  ADORA1; adenosine A1 receptor
       K04197  EDNRA; endothelin receptor type A
       K04204  NPY1R; neuropeptide Y receptor type 1
       K04217  SSTR1; somatostatin receptor 1
       K04218  SSTR2; somatostatin receptor 2
       K04221  SSTR5; somatostatin receptor 5
       K08401  GPR81; G protein-coupled receptor 81
       K08402  GPR109; G protein-coupled receptor 109
       K04328  FFAR2, GPR43; free fatty acid receptor 2
       K10042  SUCNR1, GPR91; succinate receptor 1
       K04260  PTGER3; prostaglandin E receptor 3
       K04229  OXTR; oxytocin receptor
       K04284  GHSR; growth hormone secretagogue receptor
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K11265  ADCY10; adenylate cyclase 10 [EC:4.6.1.1]
       K04955  HCN2; hyperpolarization activated cyclic nucleotide-gated potassium channel 2
       K04957  HCN4; hyperpolarization activated cyclic nucleotide-gated potassium channel 4
       K04948  CNGA1; cyclic nucleotide gated channel alpha 1
       K04949  CNGA2; cyclic nucleotide gated channel alpha 2
       K04950  CNGA3; cyclic nucleotide gated channel alpha 3
       K04951  CNGA4; cyclic nucleotide gated channel alpha 4
       K04952  CNGB1; cyclic nucleotide gated channel beta 1
       K04953  CNGB3; cyclic nucleotide gated channel beta 3
       K02183  CALM; calmodulin
       K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
       K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]
       K05673  ABCC4; ATP-binding cassette, subfamily C (CFTR/MRP), member 4
       K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
       K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
       K07829  RRAS; Ras-related protein R-Ras
       K07830  RRAS2, TC21; Ras-related protein R-Ras2
       K01115  PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
       K05860  PLCE; phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K04353  RAP1A; Ras-related protein Rap-1A
       K07836  RAP1B; Ras-related protein Rap-1B
       K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
       K05730  VAV; guanine nucleotide exchange factor VAV
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
       K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
       K12490  ARAP3; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
       K04513  RHOA; Ras homolog gene family, member A
       K05702  AF6, MLLT4; afadin
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K15494  PPP1R1B, DARPP32; protein phosphatase 1 regulatory subunit 1B
       K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K04355  BDNF; brain-derived neurotrophic factor
       K04379  FOS; proto-oncogene protein c-fos
       K04448  JUN; transcription factor AP-1
       K06230  GLI3; zinc finger protein GLI3
       K16797  GLI1; zinc finger protein GLI1
       K06225  PTCH1; patched 1
       K06231  HHIP; hedgehog interacting protein
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K18435  SOX9; transcription factor SOX9 (SOX group E)
       K04665  AMH; anti-mullerian hormone
       K07294  NR1C1, PPARA; peroxisome proliferator-activated receptor alpha
       K00232  E1.3.3.6, ACOX1, ACOX3; acyl-CoA oxidase [EC:1.3.3.6]
       K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
       K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
       K02158  BAD; BCL2-antagonist of cell death
       K07188  LIPE, HSL; hormone-sensitive lipase [EC:3.1.1.79]
       K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
       K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
       K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
       K12755  MYL9; myosin regulatory light chain 9
       K12044  TNNI3; troponin I, cardiac muscle
       K05852  PLN; phospholamban
       K04962  RYR2; ryanodine receptor 2
       K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
       K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
       K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
       K05211  GRIN2C; glutamate receptor ionotropic, NMDA 2C
       K05212  GRIN2D; glutamate receptor ionotropic, NMDA 2D
       K05213  GRIN3A; glutamate receptor ionotropic, NMDA 3A
       K05214  GRIN3B; glutamate receptor ionotropic, NMDA 3B
       K05197  GRIA1; glutamate receptor 1
       K05198  GRIA2; glutamate receptor 2
       K05199  GRIA3; glutamate receptor 3
       K05200  GRIA4; glutamate receptor 4
       K05031  CFTR; cystic fibrosis transmembrane conductance regulator [EC:3.6.3.49]
       K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]
       K01540  ATP1B; sodium/potassium-transporting ATPase subunit beta
       K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
       K13360  FXYD1, PLM; FXYD domain-containing ion transport regulator 1
       K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
       K16056  ORAI1; calcium release-activated calcium channel protein 1
       K05850  ATP2B; Ca2+ transporting ATPase, plasma membrane [EC:3.6.3.8]
       K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
       K04851  CACNA1D; voltage-dependent calcium channel L type alpha-1D
       K04853  CACNA1F; voltage-dependent calcium channel L type alpha-1F
       K04857  CACNA1S; voltage-dependent calcium channel L type alpha-1S
       K13296  PDE3; cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17]
       K13293  PDE4; cAMP-specific phosphodiesterase 4 [EC:3.1.4.53]
     04022 cGMP - PKG signaling pathway [PATH:ko04022]
       K04166  AGTR1; angiotensin II receptor type 1
       K04197  EDNRA; endothelin receptor type A
       K04198  EDNRB; endothelin receptor type B
       K04135  ADRA1A; adrenergic receptor alpha-1A
       K04136  ADRA1B; adrenergic receptor alpha-1B
       K04137  ADRA1D; adrenergic receptor alpha-1D
       K04138  ADRA2A; adrenergic receptor alpha-2A
       K04139  ADRA2B; adrenergic receptor alpha-2B
       K04140  ADRA2C; adrenergic receptor alpha-2C
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
       K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
       K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
       K04969  TRPC6; transient receptor potential cation channel subfamily C member 6
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K09260  MEF2A; MADS-box transcription enhancer factor 2A
       K09261  MEF2B; MADS-box transcription enhancer factor 2B
       K04454  MEF2C; MADS-box transcription enhancer factor 2C
       K09262  MEF2D; MADS-box transcription enhancer factor 2D
       K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
       K17332  NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2
       K17333  NFATC3, NFAT4; nuclear factor of activated T-cells, cytoplasmic 3
       K17334  NFATC4, NFAT3; nuclear factor of activated T-cells, cytoplasmic 4
       K04378  SRF; serum response factor
       K09183  GATA4; GATA-binding protein 4
       K12335  NPPB; natriuretic peptide B
       K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A [EC:4.6.1.2]
       K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B [EC:4.6.1.2]
       K07376  PRKG; protein kinase, cGMP-dependent [EC:2.7.11.12]
       K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
       K04851  CACNA1D; voltage-dependent calcium channel L type alpha-1D
       K04853  CACNA1F; voltage-dependent calcium channel L type alpha-1F
       K04857  CACNA1S; voltage-dependent calcium channel L type alpha-1S
       K04936  KCNMA1; potassium large conductance calcium-activated channel subfamily M alpha member 1
       K05274  KCNMA3; potassium large conductance calcium-activated channel subfamily M alpha member 3
       K04937  KCNMB1; potassium large conductance calcium-activated channel subfamily M beta member 1
       K04938  KCNMB2; potassium large conductance calcium-activated channel subfamily M beta member 2
       K04939  KCNMB3; potassium large conductance calcium-activated channel subfamily M beta member 3
       K04941  KCNMB4; potassium large conductance calcium-activated channel subfamily M beta member 4
       K05849  SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)
       K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]
       K01540  ATP1B; sodium/potassium-transporting ATPase subunit beta
       K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
       K05850  ATP2B; Ca2+ transporting ATPase, plasma membrane [EC:3.6.3.8]
       K18154  RGS2; regulator of G-protein signaling 2
       K03121  TFII-I, GTF2I; transcription initiation factor TFII-I
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K12337  MRVI1, IRAG; inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate
       K05852  PLN; phospholamban
       K05853  ATP2A; Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum [EC:3.6.3.8]
       K04513  RHOA; Ras homolog gene family, member A
       K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
       K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
       K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
       K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
       K02183  CALM; calmodulin
       K00907  MYLK; myosin-light-chain kinase [EC:2.7.11.18]
       K12755  MYL9; myosin regulatory light chain 9
       K04948  CNGA1; cyclic nucleotide gated channel alpha 1
       K04952  CNGB1; cyclic nucleotide gated channel beta 1
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K18283  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [EC:3.1.4.17]
       K13296  PDE3; cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17]
       K13762  PDE5; cGMP-specific 3',5'-cyclic phosphodiesterase [EC:3.1.4.35]
       K12318  GUCY1A; guanylate cyclase soluble subunit alpha [EC:4.6.1.2]
       K12319  GUCY1B; guanylate cyclase soluble subunit beta [EC:4.6.1.2]
       K03916  BDKRB2; bradykinin receptor B2
       K04213  OPRD1; delta-type opioid receptor
       K04265  ADORA1; adenosine A1 receptor
       K04268  ADORA3; adenosine A3 receptor
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K04526  INS; insulin
       K04527  INSR; insulin receptor [EC:2.7.10.1]
       K16172  IRS1; insulin receptor substrate 1
       K07187  IRS2; insulin receptor substrate 2
       K17445  IRS3; insulin receptor substrate 3
       K17446  IRS4; insulin receptor substrate 4
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K13242  NOS3; nitric-oxide synthase, endothelial [EC:1.14.13.39]
       K04141  ADRB1; adrenergic receptor beta-1
       K04142  ADRB2; adrenergic receptor beta-2
       K04143  ADRB3; adrenergic receptor beta-3
       K18050  PRKCE; novel protein kinase C epsilon type [EC:2.7.11.13]
       K05001  KCNJ8; potassium inwardly-rectifying channel subfamily J member 8
       K05862  VDAC1; voltage-dependent anion channel protein 1
       K15040  VDAC2; voltage-dependent anion channel protein 2
       K15041  VDAC3; voltage-dependent anion channel protein 3
       K05863  SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31
       K09565  PPIF; peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K02158  BAD; BCL2-antagonist of cell death
       K06274  VASP; vasodilator-stimulated phosphoprotein
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
     04151 PI3K-Akt signaling pathway [PATH:ko04151]
       K04357  EGF; epidermal growth factor
       K18496  FGF1; fibroblast growth factor 1
       K18497  FGF2; fibroblast growth factor 2
       K04358  FGF; fibroblast growth factor
       K05451  NGFA; nerve growth factor, alpha
       K02582  NGFB; nerve growth factor, beta
       K04526  INS; insulin
       K05459  IGF1; insulin-like growth factor 1
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K05450  PDGFC_D; platelet derived growth factor C/D
       K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
       K05461  KITLG; KIT ligand
       K05448  VEGFA; vascular endothelial growth factor A
       K16858  VEGFB; vascular endothelial growth factor B
       K16859  PGF; placenta growth factor
       K05449  VEGFC_D; vascular endothelial growth factor C/D
       K05460  HGF; hepatocyte growth factor
       K05465  ANGPT1; angiopoietin 1
       K05466  ANGPT2; angiopoietin 2
       K05467  ANGPT4; angiopoietin 4
       K05462  EFNA; ephrin-A
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K04362  FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K05093  FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
       K05094  FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]
       K05095  FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]
       K02583  NGFR; nerve growth factor receptor (TNFR superfamily member 16)
       K04527  INSR; insulin receptor [EC:2.7.10.1]
       K05087  IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K04363  PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K05090  CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
       K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
       K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
       K05098  KDR, VEGFR2; kinase insert domain protein receptor [EC:2.7.10.1]
       K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
       K05121  TEK, TIE2; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]
       K05103  EPHA2, ECK; Eph receptor A2 [EC:2.7.10.1]
       K04364  GRB2; growth factor receptor-binding protein 2
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K16172  IRS1; insulin receptor substrate 1
       K10159  TLR2; toll-like receptor 2
       K10160  TLR4; toll-like receptor 4
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K06856  IGH; immunoglobulin heavy chain
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K06465  CD19; CD19 antigen
       K12230  PIK3AP1, BCAP; phosphoinositide 3-kinase adapter protein 1
       K05438  GH; growth hormone
       K05439  PRL; prolactin
       K05418  OSM; oncostatin M
       K05429  IL2; interleukin 2
       K04736  IL3; interleukin 3
       K05405  IL6; interleukin 6
       K05430  IL4; interleukin 4
       K05431  IL7; interleukin 7
       K05414  IFNA; interferon alpha
       K05415  IFNB; interferon beta
       K05437  EPO; erythropoietin
       K05423  CSF3, GCSF; granulocyte colony-stimulating factor
       K05080  GHR; growth hormone receptor
       K05081  PRLR; prolactin receptor
       K05057  OSMR; oncostatin M receptor
       K05068  IL2RA, CD25; interleukin 2 receptor alpha
       K05069  IL2RB; interleukin 2 receptor beta
       K05070  IL2RG; interleukin 2 receptor gamma
       K04737  IL3RA; interleukin 3 receptor alpha
       K05055  IL6R; interleukin 6 receptor
       K05071  IL4R; interleukin 4 receptor
       K05072  IL7R; interleukin 7 receptor
       K05130  IFNAR1; interferon receptor 1
       K05131  IFNAR2; interferon receptor 2
       K05079  EPOR; erythropoietin receptor
       K05061  CSF3R; granulocyte colony-stimulating factor receptor
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
       K11218  JAK3; Janus kinase 3 [EC:2.7.10.2]
       K06236  COL1AS; collagen, type I/II/III/V/XI/XXIV/XXVII, alpha
       K06237  COL4A; collagen, type IV, alpha
       K06238  COL6A; collagen, type VI, alpha
       K05637  LAMA1_2; laminin, alpha 1/2
       K06240  LAMA3_5; laminin, alpha 3/5
       K06241  LAMA4; laminin, alpha 4
       K05636  LAMB1; laminin, beta 1
       K06243  LAMB2; laminin, beta 2
       K06244  LAMB3; laminin, beta 3
       K06245  LAMB4; laminin, beta 4
       K05635  LAMC1; laminin, gamma 1
       K06246  LAMC2; laminin, gamma 2
       K06247  LAMC3; laminin, gamma 3
       K06248  CHAD; chondroadherin
       K06249  RELN; reelin [EC:3.4.21.-]
       K16857  THBS1; thrombospondin 1
       K04659  THBS2S; thrombospondin 2/3/4/5
       K05717  FN1; fibronectin 1
       K06250  SPP1, BNSP, OPN; secreted phosphoprotein 1
       K06251  VTN; vitronectin
       K06252  TN; tenascin
       K03900  VWF; von Willebrand factor
       K06253  IBSP; integrin binding sialoprotein
       K06480  ITGA1; integrin alpha 1
       K06481  ITGA2; integrin alpha 2
       K06476  ITGA2B; integrin alpha 2B
       K06482  ITGA3; integrin alpha 3
       K06483  ITGA4; integrin alpha 4
       K06484  ITGA5; integrin alpha 5
       K06485  ITGA6; integrin alpha 6
       K06583  ITGA7; integrin alpha 7
       K06584  ITGA8; integrin alpha 8
       K06585  ITGA9; integrin alpha 9
       K06586  ITGA10; integrin alpha 10
       K06587  ITGA11; integrin alpha 11
       K06487  ITGAV; integrin alpha V
       K05719  ITGB1; integrin beta 1
       K06493  ITGB3; integrin beta 3
       K06525  ITGB4; integrin beta 4
       K06588  ITGB5; integrin beta 5
       K06589  ITGB6; integrin beta 6
       K06590  ITGB7; integrin beta 7
       K06591  ITGB8; integrin beta 8
       K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
       K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
       K04129  CHRM1; muscarinic acetylcholine receptor M1
       K04130  CHRM2; muscarinic acetylcholine receptor M2
       K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
       K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
       K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
       K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
       K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
       K04273  LPAR6, P2RY5; lysophosphatidic acid receptor 6
       K04536  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
       K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
       K07825  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
       K04538  GNB4; guanine nucleotide-binding protein subunit beta-4
       K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
       K07826  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
       K04540  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
       K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
       K04542  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
       K04543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
       K04544  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
       K04545  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
       K04546  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K04547  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
       K04548  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
       K04549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
       K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
       K07298  STK11, LKB1; serine/threonine-protein kinase 11
       K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
       K08270  DDIT4, REDD1; DNA-damage-inducible transcript 4
       K07206  TSC1; tuberous sclerosis 1
       K07207  TSC2; tuberous sclerosis 2
       K07208  RHEB; Ras homolog enriched in brain
       K08266  GBL; G protein beta subunit-like
       K07203  FRAP; FKBP12-rapamycin complex-associated protein
       K07204  RAPTOR; regulatory associated protein of mTOR
       K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
       K03259  EIF4E; translation initiation factor 4E
       K04688  RPS6KB; p70 ribosomal S6 kinase [EC:2.7.11.1]
       K03258  EIF4B; translation initiation factor 4B
       K02991  RP-S6e, RPS6; small subunit ribosomal protein S6e
       K06071  PKN; protein kinase N [EC:2.7.11.13]
       K13302  SGK1; serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
       K13303  SGK2; serum/glucocorticoid-regulated kinase 2 [EC:2.7.11.1]
       K13304  SGK3; serum/glucocorticoid-regulated kinase 3 [EC:2.7.11.1]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
       K16339  THEM4, CTMP; thioesterase superfamily member 4
       K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
       K03456  PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
       K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
       K11583  PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
       K11584  PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
       K04079  htpG, HSP90A; molecular chaperone HtpG
       K09487  HSP90B, TRA1; heat shock protein 90kDa beta
       K09554  CDC37; cell division cycle protein 37
       K16333  CRTC2, TORC2; CREB-regulated transcription coactivator 2
       K16340  PHLPP; PH domain and leucine-rich repeat-containing protein phosphatase [EC:3.1.3.16]
       K10167  TCL1A; T-cell leukemia/lymphoma 1A
       K16836  TCL1B; T-cell leukemia/lymphoma 1B
       K16837  MTCP1; mature T-cell proliferation-1 type B1
       K13242  NOS3; nitric-oxide synthase, endothelial [EC:1.14.13.39]
       K10605  BRCA1; breast cancer type 1 susceptibility protein
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K00693  GYS; glycogen(starch) synthase [EC:2.4.1.11]
       K01596  E4.1.1.32, pckA, PEPCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
       K01084  G6PC; glucose-6-phosphatase [EC:3.1.3.9]
       K04377  MYC; Myc proto-oncogene protein
       K04503  CCND1; cyclin D1
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K10151  CCND2; cyclin D2
       K10152  CCND3; cyclin D3
       K06626  CCNE; cyclin E
       K09408  FOXO3; forkhead box protein O3
       K16332  RBL2; retinoblastoma-like protein 2
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K16341  BCL2L11, BIM; Bcl-2-like protein 11
       K16197  YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
       K06630  YWHAE; 14-3-3 protein epsilon
       K16198  YWHAG_H; 14-3-3 protein gamma/eta
       K02158  BAD; BCL2-antagonist of cell death
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K02161  BCL2; apoptosis regulator BCL-2
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1
       K08524  NR2B1, RXRA; retinoid X receptor alpha
       K04465  NR4A1, HMR; nuclear receptor subfamily 4 group A member 1
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K04735  RELA; transcription factor p65
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K09420  MYB; myb proto-oncogene protein
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
       K04451  TP53, P53; tumor protein p53
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
     04152 AMPK signaling pathway [PATH:ko04152]
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K07298  STK11, LKB1; serine/threonine-protein kinase 11
       K08272  CAB39, MO25; calcium binding protein 39
       K08271  STRADA, LYK5; STE20-related kinase adapter protein alpha
       K17532  STRADB; STE20-related kinase adapter protein beta
       K05424  LEP; leptin
       K05062  LEPR; leptin receptor
       K07359  CAMKK; calcium/calmodulin-dependent protein kinase kinase [EC:2.7.11.17]
       K04135  ADRA1A; adrenergic receptor alpha-1A
       K07296  ACDC; adiponectin
       K07297  ADIPOR; adiponectin receptor
       K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
       K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
       K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
       K01103  PFKFB; 6-phosphofructo-2-kinase / fructose-2,6-bisphosphatase [EC:2.7.1.105 3.1.3.46]
       K03841  FBP, fbp; fructose-1,6-bisphosphatase I [EC:3.1.3.11]
       K00850  pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]
       K07292  NR2A1, HNF4A; hepatocyte nuclear factor 4-alpha
       K01084  G6PC; glucose-6-phosphatase [EC:3.1.3.9]
       K01596  E4.1.1.32, pckA, PEPCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
       K16333  CRTC2, TORC2; CREB-regulated transcription coactivator 2
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K07202  PPARGC1A, PGC1A; alpha peroxisome proliferator-activated receptor gamma coactivator 1-alpha
       K13088  ELAVL1, HUR; ELAV-like protein 1
       K04503  CCND1; cyclin D1
       K06627  CCNA; cyclin A
       K08292  EEF2K; elongation factor 2 kinase [EC:2.7.11.20]
       K03234  EEF2; elongation factor 2
       K07201  FOXO1; forkhead box protein O1
       K09408  FOXO3; forkhead box protein O3
       K11411  SIRT1, SIR2L1; NAD-dependent deacetylase sirtuin 1 [EC:3.5.1.-]
       K07191  SLC2A4, GLUT4; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 4
       K00693  GYS; glycogen(starch) synthase [EC:2.4.1.11]
       K07188  LIPE, HSL; hormone-sensitive lipase [EC:3.1.1.79]
       K00021  HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34]
       K07197  SREBP1, SREBF1; sterol regulatory element-binding transcription factor 1
       K00665  FASN; fatty acid synthase, animal type [EC:2.3.1.85]
       K11262  ACAC; acetyl-CoA carboxylase / biotin carboxylase [EC:6.4.1.2 6.3.4.14]
       K00507  SCD, desC; stearoyl-CoA desaturase (delta-9 desaturase) [EC:1.14.19.1]
       K01578  MLYCD; malonyl-CoA decarboxylase [EC:4.1.1.9]
       K08765  CPT1; carnitine O-palmitoyltransferase 1 [EC:2.3.1.21]
       K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
       K03456  PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
       K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
       K11583  PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
       K11584  PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
       K18341  TBC1D1; TBC1 domain family member 1
       K07877  RAB2A; Ras-related protein Rab-2A
       K07901  RAB8A, MEL; Ras-related protein Rab-8A
       K07903  RAB10; Ras-related protein Rab-10
       K07905  RAB11B; Ras-related protein Rab-11B
       K07881  RAB14; Ras-related protein Rab-14
       K05031  CFTR; cystic fibrosis transmembrane conductance regulator [EC:3.6.3.49]
       K06259  CD36; CD36 antigen
       K05459  IGF1; insulin-like growth factor 1
       K05087  IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K04526  INS; insulin
       K04527  INSR; insulin receptor [EC:2.7.10.1]
       K16172  IRS1; insulin receptor substrate 1
       K07187  IRS2; insulin receptor substrate 2
       K17445  IRS3; insulin receptor substrate 3
       K17446  IRS4; insulin receptor substrate 4
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K07207  TSC2; tuberous sclerosis 2
       K07206  TSC1; tuberous sclerosis 1
       K07208  RHEB; Ras homolog enriched in brain
       K07203  FRAP; FKBP12-rapamycin complex-associated protein
       K07204  RAPTOR; regulatory associated protein of mTOR
       K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
       K04688  RPS6KB; p70 ribosomal S6 kinase [EC:2.7.11.1]
       K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
       K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
     04150 mTOR signaling pathway [PATH:ko04150]
     04075 Plant hormone signal transduction [PATH:ko04075]
 
   Signaling molecules and interaction
 
 Cellular Processes
 
 Organismal Systems
 
   Immune system
     04640 Hematopoietic cell lineage [PATH:ko04640]
     04610 Complement and coagulation cascades [PATH:ko04610]
     04611 Platelet activation [PATH:ko04611]
     04620 Toll-like receptor signaling pathway [PATH:ko04620]
     04621 NOD-like receptor signaling pathway [PATH:ko04621]
     04622 RIG-I-like receptor signaling pathway [PATH:ko04622]
     04623 Cytosolic DNA-sensing pathway [PATH:ko04623]
     04650 Natural killer cell mediated cytotoxicity [PATH:ko04650]
     04612 Antigen processing and presentation [PATH:ko04612]
       K04687  IFNG; interferon gamma
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K06696  PSME1; proteasome activator subunit 1 (PA28 alpha)
       K06697  PSME2; proteasome activator subunit 2 (PA28 beta)
       K06698  PSME3; proteasome activator subunit 3 (PA28 gamma)
       K03283  HSPA1_8; heat shock 70kDa protein 1/8
       K09489  HSPA4; heat shock 70kDa protein 4
       K04079  htpG, HSP90A; molecular chaperone HtpG
       K06751  MHC1; major histocompatibility complex, class I
       K08054  CANX; calnexin
       K08055  B2M; beta-2-microglobulin
       K08056  PDIA3, GRP58; protein disulfide isomerase family A, member 3 [EC:5.3.4.1]
       K08057  CALR; calreticulin
       K08058  TAPBP; TAP binding protein (tapasin)
       K05653  ABCB2, TAP1; ATP-binding cassette, subfamily B (MDR/TAP), member 2
       K05654  ABCB3, TAP2; ATP-binding cassette, subfamily B (MDR/TAP), member 3
       K06458  CD8A; CD8A antigen, alpha polypeptide
       K06459  CD8B; CD8B antigen, beta polypeptide
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K07980  KIR3DL; killer cell immunoglobulin-like receptor 3DL
       K07981  KIR2DL; killer cell immunoglobulin-like receptor 2DL
       K06541  KLRC; killer cell lectin-like receptor subfamily C
       K06516  KLRD1, CD94; killer cell lectin-like receptor subfamily D member 1
       K07982  KIR2DS; killer cell immunoglobulin-like receptor 2DS
       K08059  IFI30, GILT; interferon, gamma-inducible protein 30
       K01369  LGMN; legumain [EC:3.4.22.34]
       K01363  CTSB; cathepsin B [EC:3.4.22.1]
       K06752  MHC2; major histocompatibility complex, class II
       K06505  CD74, DHLAG; CD74 antigen
       K01365  CTSL; cathepsin L [EC:3.4.22.15]
       K01368  CTSS; cathepsin S [EC:3.4.22.27]
       K06454  CD4; CD4 antigen
       K08060  CIITA; class II, major histocompatibility complex, transactivator
       K08061  RFX5; regulatory factor X 5
       K08062  RFXANK; regulatory factor X-associated ankyrin-containing protein
       K08063  RFXAP; regulatory factor X-associated protein
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K08064  NFYA; nuclear transcription factor Y, alpha
       K08065  NFYB; nuclear transcription Y subunit beta
       K08066  NFYC; nuclear transcription factor Y, gamma
     04660 T cell receptor signaling pathway [PATH:ko04660]
     04662 B cell receptor signaling pathway [PATH:ko04662]
     04664 Fc epsilon RI signaling pathway [PATH:ko04664]
     04666 Fc gamma R-mediated phagocytosis [PATH:ko04666]
     04670 Leukocyte transendothelial migration [PATH:ko04670]
     04672 Intestinal immune network for IgA production [PATH:ko04672]
     04062 Chemokine signaling pathway [PATH:ko04062]
 
   Endocrine system
     04911 Insulin secretion [PATH:ko04911]
       K07299  SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
       K07593  SLC2A2, GLUT2; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 2
       K12407  GCK; glucokinase [EC:2.7.1.2]
       K04979  TRPM4; transient receptor potential cation channel subfamily M member 4
       K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]
       K01540  ATP1B; sodium/potassium-transporting ATPase subunit beta
       K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
       K05032  ABCC8, SUR1; ATP-binding cassette subfamily C (CFTR/MRP) member 8
       K05004  KCNJ11; potassium inwardly-rectifying channel subfamily J member 11
       K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
       K04851  CACNA1D; voltage-dependent calcium channel L type alpha-1D
       K04853  CACNA1F; voltage-dependent calcium channel L type alpha-1F
       K04857  CACNA1S; voltage-dependent calcium channel L type alpha-1S
       K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
       K04936  KCNMA1; potassium large conductance calcium-activated channel subfamily M alpha member 1
       K05274  KCNMA3; potassium large conductance calcium-activated channel subfamily M alpha member 3
       K04937  KCNMB1; potassium large conductance calcium-activated channel subfamily M beta member 1
       K04938  KCNMB2; potassium large conductance calcium-activated channel subfamily M beta member 2
       K04939  KCNMB3; potassium large conductance calcium-activated channel subfamily M beta member 3
       K04941  KCNMB4; potassium large conductance calcium-activated channel subfamily M beta member 4
       K04942  KCNN1; potassium intermediate/small conductance calcium-activated channel subfamily N member 1
       K04943  KCNN2; potassium intermediate/small conductance calcium-activated channel subfamily N member 2
       K04944  KCNN3; potassium intermediate/small conductance calcium-activated channel subfamily N member 3
       K04945  KCNN4; potassium intermediate/small conductance calcium-activated channel subfamily N member 4
       K05325  KCNNN; potassium intermediate/small conductance calcium-activated channel subfamily N, invertebrate
       K05259  GCG; glucagon
       K04581  GLP1R; glucagon-like peptide 1 receptor
       K05258  GIP; gastric inhibitory polypeptide
       K08424  GPR119; G protein-coupled receptor 119
       K05262  ADCYAP; adenylate cyclase activating polypeptide
       K04587  ADCYAP1R1, PACAPRI; pituitary adenylate cyclase-activating polypeptide type I receptor
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K07594  IPF1, PDX1; insulin promoter factor 1
       K04526  INS; insulin
       K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
       K15297  RIMS2, RIM2; regulating synaptic membrane exocytosis protein 2
       K16882  PCLO; protein piccolo
       K07882  RAB3A; Ras-related protein Rab-3A
       K04194  CCKAR; cholecystokinin A receptor
       K04131  CHRM3; muscarinic acetylcholine receptor M3
       K04325  FFAR1, GPR40; free fatty acid receptor 1
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K04962  RYR2; ryanodine receptor 2
       K13504  VAMP2; vesicle-associated membrane protein 2
       K04560  STX1A; syntaxin 1A
       K18211  SNAP25; synaptosomal-associated protein 25
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
     04910 Insulin signaling pathway [PATH:ko04910]
     04920 Adipocytokine signaling pathway [PATH:ko04920]
     03320 PPAR signaling pathway [PATH:ko03320]
     04912 GnRH signaling pathway [PATH:ko04912]
     04913 Ovarian Steroidogenesis [PATH:ko04913]
     04915 Estrogen signaling pathway [PATH:ko04915]
       K08550  NR3A1, ESR1; estrogen receptor alpha
       K08551  NR3A2, ESR2; estrogen receptor beta
       K04079  htpG, HSP90A; molecular chaperone HtpG
       K09487  HSP90B, TRA1; heat shock protein 90kDa beta
       K09571  FKBP4_5; FK506-binding protein 4/5 [EC:5.2.1.8]
       K03283  HSPA1_8; heat shock 70kDa protein 1/8
       K04379  FOS; proto-oncogene protein c-fos
       K04448  JUN; transcription factor AP-1
       K04684  SP1; transcription factor Sp1
       K04246  GPR30; G protein-coupled receptor 30
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K01398  MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
       K01403  MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
       K08523  HBEGF; heparin-binding EGF-like growth factor
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K06279  SHC1; SHC- transforming protein 1
       K17447  SHC2; SHC- transforming protein 2
       K17448  SHC3; SHC- transforming protein 3
       K17449  SHC4; SHC- transforming protein 4
       K04364  GRB2; growth factor receptor-binding protein 2
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04615  GABBR; gamma-aminobutyric acid type B receptor
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
       K04997  KCNJ3; potassium inwardly-rectifying channel subfamily J member 3
       K05000  KCNJ6; potassium inwardly-rectifying channel subfamily J member 6
       K05002  KCNJ9; potassium inwardly-rectifying channel subfamily J member 9
       K04999  KCNJ5; potassium inwardly-rectifying channel subfamily J member 5
       K04215  OPRM1; mu-type opioid receptor
       K06068  PRKCD; novel protein kinase C delta type [EC:2.7.11.13]
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K02183  CALM; calmodulin
       K13242  NOS3; nitric-oxide synthase, endothelial [EC:1.14.13.39]
       K04603  GRM1; metabotropic glutamate receptor 1
     04914 Progesterone-mediated oocyte maturation [PATH:ko04914]
     04917 Prolactin signaling pathway [PATH:ko04917]
     04921 Oxytocin signaling pathway [PATH:ko04921]
     04918 Thyroid hormone synthesis [PATH:ko04918]
       K05251  TSHB; thyroid stimulating hormone, beta
       K08522  CGA; glycoprotein hormones, alpha polypeptide
       K04249  TSHR; thyroid stimulating hormone receptor
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
       K15225  TTF1; transcription termination factor 1
       K15173  TTF2; transcription termination factor 2 [EC:3.6.4.-]
       K09293  PAX8; paired box protein 8
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K10809  TG; thyroglobulin
       K09490  HSPA5, BIP; heat shock 70kDa protein 5
       K09487  HSP90B, TRA1; heat shock protein 90kDa beta
       K08054  CANX; calnexin
       K09582  PDIA4, ERP72; protein disulfide-isomerase A4 [EC:5.3.4.1]
       K10063  ASGR1; asialoglycoprotein receptor 1
       K10064  ASGR2; asialoglycoprotein receptor 2
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K14385  SLC5A5, NIS; solute carrier family 5 (sodium/iodide cotransporter), member 5
       K14702  SLC26A4, PDS; solute carrier family 26 (sodium-independent chloride/iodide transporter), member 4
       K00431  TPO; thyroid peroxidase [EC:1.11.1.8]
       K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]
       K01540  ATP1B; sodium/potassium-transporting ATPase subunit beta
       K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
       K17231  IYD, DEHAL1; iodotyrosine deiodinase [EC:1.22.1.1]
       K17232  DUOXA2; dual oxidase maturation factor 2
       K00432  E1.11.1.9; glutathione peroxidase [EC:1.11.1.9]
       K00383  GSR, gor; glutathione reductase (NADPH) [EC:1.8.1.7]
       K06233  LRP2; low density lipoprotein-related protein 2
     04919 Thyroid hormone signaling pathway [PATH:ko04919]
     04916 Melanogenesis [PATH:ko04916]
       K05228  POMC; proopiomelanocortin
       K08725  ASIP; agouti signaling protein
       K04199  MC1R; melanocortin 1 receptor
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K09455  MITF; microphthalmia-associated transcription factor
       K03209  WNT1; wingless-type MMTV integration site family, member 1
       K00182  WNT2; wingless-type MMTV integration site family, member 2
       K00312  WNT3; wingless-type MMTV integration site family, member 3
       K00408  WNT4; wingless-type MMTV integration site family, member 4
       K00444  WNT5; wingless-type MMTV integration site family, member 5
       K00445  WNT6; wingless-type MMTV integration site family, member 6
       K00572  WNT7; wingless-type MMTV integration site family, member 7
       K00714  WNT8; wingless-type MMTV integration site family, member 8
       K01064  WNT9; wingless-type MMTV integration site family, member 9
       K01357  WNT10; wingless-type MMTV integration site family, member 10
       K01384  WNT11; wingless-type MMTV integration site family, member 11
       K01558  WNT16; wingless-type MMTV integration site family, member 16
       K02432  FZD1_7, fz; frizzled 1/7
       K02235  FZD2; frizzled 2
       K02329  FZD3; frizzled 3
       K02354  FZD4, fz4; frizzled 4
       K02375  FZD5_8, fz2; frizzled 5/8
       K02376  FZD6; frizzled 6
       K02842  FZD9_10; frizzled 9/10
       K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K02353  DVL; segment polarity protein dishevelled
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K02105  CTNNB1; catenin beta 1
       K02620  TCF7; transcription factor 7
       K04490  TCF7L1; transcription factor 7-like 1
       K04491  TCF7L2; transcription factor 7-like 2
       K04492  LEF1; lymphoid enhancer-binding factor 1
       K05461  KITLG; KIT ligand
       K05091  KIT, SCFR; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K00505  TYR; tyrosinase [EC:1.14.18.1]
       K00506  TYRP1; tyrosinase-related protein 1 [EC:1.14.18.-]
       K01827  DCT; dopachrome tautomerase [EC:5.3.3.12]
       K16366  EDN1; endothelin-1
       K04198  EDNRB; endothelin receptor type B
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K02183  CALM; calmodulin
       K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
     04614 Renin-angiotensin system [PATH:ko04614]
 
   Circulatory system
     04260 Cardiac muscle contraction [PATH:ko04260]
     04261 Adrenergic signaling in cardiomyocytes [PATH:ko04261]
       K04141  ADRB1; adrenergic receptor beta-1
       K04142  ADRB2; adrenergic receptor beta-2
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]
       K01540  ATP1B; sodium/potassium-transporting ATPase subunit beta
       K01538  FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
       K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
       K04926  KCNQ1; potassium voltage-gated channel KQT-like subfamily member 1
       K04894  KCNE1; potassium voltage-gated channel Isk-related subfamily E member 1
       K05850  ATP2B; Ca2+ transporting ATPase, plasma membrane [EC:3.6.3.8]
       K04838  SCN5A; voltage-gated sodium channel type V alpha
       K04839  SCN7A, SCN6A; voltage-gated sodium channel type VII alpha
       K04845  SCN1B; voltage-gated sodium channel type I beta
       K04848  SCN4B; voltage-gated sodium channel type IV beta
       K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
       K04851  CACNA1D; voltage-dependent calcium channel L type alpha-1D
       K04853  CACNA1F; voltage-dependent calcium channel L type alpha-1F
       K04857  CACNA1S; voltage-dependent calcium channel L type alpha-1S
       K04862  CACNB1; voltage-dependent calcium channel beta-1
       K04863  CACNB2; voltage-dependent calcium channel beta-2
       K04864  CACNB3; voltage-dependent calcium channel beta-3
       K04865  CACNB4; voltage-dependent calcium channel beta-4
       K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
       K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
       K04860  CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3
       K04861  CACNA2D4; voltage-dependent calcium channel alpha-2/delta-4
       K04866  CACNG1; voltage-dependent calcium channel gamma-1
       K04867  CACNG2; voltage-dependent calcium channel gamma-2
       K04868  CACNG3; voltage-dependent calcium channel gamma-3
       K04869  CACNG4; voltage-dependent calcium channel gamma-4
       K04870  CACNG5; voltage-dependent calcium channel gamma-5
       K04871  CACNG6; voltage-dependent calcium channel gamma-6
       K04872  CACNG7; voltage-dependent calcium channel gamma-7
       K04873  CACNG8; voltage-dependent calcium channel gamma-8
       K02183  CALM; calmodulin
       K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
       K04962  RYR2; ryanodine receptor 2
       K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
       K03456  PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
       K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
       K11583  PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
       K11584  PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
       K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
       K05865  TNNC1; troponin C, slow skeletal and cardiac muscles
       K12044  TNNI3; troponin I, cardiac muscle
       K12045  TNNT2; troponin T, cardiac muscle
       K10373  TPM1; tropomyosin 1
       K10374  TPM2; tropomyosin 2
       K09290  TPM3; tropomyosin 3
       K10375  TPM4; tropomyosin 4
       K12314  ACTC1; actin, alpha cardiac muscle
       K17751  MYH6_7; myosin heavy chain 6/7
       K10351  MYL2; myosin regulatory light chain 2
       K12749  MYL3; myosin light chain 3
       K12750  MYL4; myosin light chain 4
       K05852  PLN; phospholamban
       K04166  AGTR1; angiotensin II receptor type 1
       K04167  AGTR2; angiotensin II receptor type 2
       K04135  ADRA1A; adrenergic receptor alpha-1A
       K04136  ADRA1B; adrenergic receptor alpha-1B
       K04137  ADRA1D; adrenergic receptor alpha-1D
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K08050  PPP1R1A; protein phosphatase 1 regulatory subunit 1A
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04445  MSK1, RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K09052  CREM; cAMP response element modulator
       K02161  BCL2; apoptosis regulator BCL-2
       K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
       K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
     04270 Vascular smooth muscle contraction [PATH:ko04270]
 
   Digestive system
 
   Excretory system
     04962 Vasopressin-regulated water reabsorption [PATH:ko04962]
       K05242  AVP; arginine vasopressin
       K04228  AVPR2; arginine vasopressin receptor 2
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K12462  ARHGDI, RHOGDI; Rho GDP-dissociation inhibitor
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09865  AQP2; aquaporin-2
       K07904  RAB11A; Ras-related protein Rab-11A
       K07905  RAB11B; Ras-related protein Rab-11B
       K10413  DYNC1H; dynein heavy chain 1, cytosolic
       K10414  DYNC2H, DNCH2; dynein heavy chain 2, cytosolic
       K10415  DYNC1I, DNCI; dynein intermediate chain, cytosolic
       K10416  DYNC1LI, DNCLI; dynein light intermediate chain 1, cytosolic
       K10417  DYNC2LI; dynein light intermediate chain 2, cytosolic
       K10418  DYNLL; dynein light chain LC8-type
       K04648  DCTN1; dynactin 1
       K10424  DCTN2; dynactin 2
       K10426  DCTN4; dynactin 4
       K10427  DCTN5; dynactin 5
       K10428  DCTN6; dynactin 6
       K13504  VAMP2; vesicle-associated membrane protein 2
       K06027  NSF; vesicle-fusing ATPase [EC:3.6.4.6]
       K13502  STX4; syntaxin 4
       K07887  RAB5A; Ras-related protein Rab-5A
       K07888  RAB5B; Ras-related protein Rab-5B
       K07889  RAB5C; Ras-related protein Rab-5C
       K09866  AQP4; aquaporin-4
       K09876  AQP3; aquaporin-3
     04960 Aldosterone-regulated sodium reabsorption [PATH:ko04960]
     04961 Endocrine and other factor-regulated calcium reabsorption [PATH:ko04961]
     04964 Proximal tubule bicarbonate reclamation [PATH:ko04964]
     04966 Collecting duct acid secretion [PATH:ko04966]
 
   Nervous system
     04724 Glutamatergic synapse [PATH:ko04724]
     04727 GABAergic synapse [PATH:ko04727]
     04725 Cholinergic synapse [PATH:ko04725]
       K00623  CHAT; choline O-acetyltransferase [EC:2.3.1.6]
       K01049  ACHE; acetylcholinesterase [EC:3.1.1.7]
       K14636  SLC18A3, VACHT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular acetylcholine transporter), member 3
       K04129  CHRM1; muscarinic acetylcholine receptor M1
       K04131  CHRM3; muscarinic acetylcholine receptor M3
       K04133  CHRM5; muscarinic acetylcholine receptor M5
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
       K04926  KCNQ1; potassium voltage-gated channel KQT-like subfamily member 1
       K04927  KCNQ2; potassium voltage-gated channel KQT-like subfamily member 2
       K04928  KCNQ3; potassium voltage-gated channel KQT-like subfamily member 3
       K04929  KCNQ4; potassium voltage-gated channel KQT-like subfamily member 4
       K04930  KCNQ5; potassium voltage-gated channel KQT-like subfamily member 5
       K04996  KCNJ2; potassium inwardly-rectifying channel subfamily J member 2
       K05005  KCNJ12; potassium inwardly-rectifying channel subfamily J member 12
       K04998  KCNJ4; potassium inwardly-rectifying channel subfamily J member 4
       K05007  KCNJ14; potassium inwardly-rectifying channel subfamily J member 14
       K04130  CHRM2; muscarinic acetylcholine receptor M2
       K04132  CHRM4; muscarinic acetylcholine receptor M4
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
       K04536  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
       K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
       K07825  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
       K04538  GNB4; guanine nucleotide-binding protein subunit beta-4
       K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
       K07826  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
       K04540  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
       K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
       K04542  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
       K04543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
       K04544  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
       K04545  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
       K04546  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K04547  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
       K04548  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
       K04549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
       K04997  KCNJ3; potassium inwardly-rectifying channel subfamily J member 3
       K05000  KCNJ6; potassium inwardly-rectifying channel subfamily J member 6
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04379  FOS; proto-oncogene protein c-fos
       K04809  CHRNA7; nicotinic acetylcholine receptor alpha-7
       K04806  CHRNA4; nicotinic acetylcholine receptor alpha-4
       K04813  CHRNB2; nicotinic acetylcholine receptor beta-2
       K04805  CHRNA3; nicotinic acetylcholine receptor alpha-3
       K04815  CHRNB4; nicotinic acetylcholine receptor beta-4
       K04808  CHRNA6; nicotinic acetylcholine receptor alpha-6
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
       K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]
       K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
       K05703  FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K02161  BCL2; apoptosis regulator BCL-2
       K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
       K04849  CACNA1B; voltage-dependent calcium channel N type alpha-1B
       K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
       K04851  CACNA1D; voltage-dependent calcium channel L type alpha-1D
       K04853  CACNA1F; voltage-dependent calcium channel L type alpha-1F
       K04857  CACNA1S; voltage-dependent calcium channel L type alpha-1S
       K14387  SLC5A7, CHT1; solute carrier family 5 (high affinity choline transporter), member 7
     04728 Dopaminergic synapse [PATH:ko04728]
       K00501  TH; tyrosine 3-monooxygenase [EC:1.14.16.2]
       K01593  DDC; aromatic-L-amino-acid decarboxylase [EC:4.1.1.28]
       K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
       K04144  DRD1; dopamine receptor D1
       K05840  DRD5; dopamine receptor D5
       K15493  CALY; neuron-specific vesicular protein calcyon
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K02183  CALM; calmodulin
       K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
       K04379  FOS; proto-oncogene protein c-fos
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K15494  PPP1R1B, DARPP32; protein phosphatase 1 regulatory subunit 1B
       K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
       K04833  SCN1A; voltage-gated sodium channel type I alpha
       K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
       K04851  CACNA1D; voltage-dependent calcium channel L type alpha-1D
       K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
       K04849  CACNA1B; voltage-dependent calcium channel N type alpha-1B
       K04997  KCNJ3; potassium inwardly-rectifying channel subfamily J member 3
       K05000  KCNJ6; potassium inwardly-rectifying channel subfamily J member 6
       K05002  KCNJ9; potassium inwardly-rectifying channel subfamily J member 9
       K04999  KCNJ5; potassium inwardly-rectifying channel subfamily J member 5
       K04146  DRD3; dopamine receptor D3
       K04147  DRD4; dopamine receptor D4
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
       K04536  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
       K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
       K07825  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
       K04538  GNB4; guanine nucleotide-binding protein subunit beta-4
       K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
       K07826  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
       K04540  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
       K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
       K04542  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
       K04543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
       K04544  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
       K04545  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
       K04546  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K04547  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
       K04548  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
       K04549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
       K04145  DRD2; dopamine receptor D2
       K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
       K03456  PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
       K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
       K11583  PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
       K11584  PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K08822  GSK3A; glycogen synthase kinase 3 alpha [EC:2.7.11.26]
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
       K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
       K05197  GRIA1; glutamate receptor 1
       K05198  GRIA2; glutamate receptor 2
       K05199  GRIA3; glutamate receptor 3
       K05200  GRIA4; glutamate receptor 4
       K10396  KIF5; kinesin family member 5
       K02223  CLOCK, KAT13D; circadian locomoter output cycles kaput protein [EC:2.3.1.48]
       K02296  ARNTL, BMAL1, CYC; aryl hydrocarbon receptor nuclear translocator-like protein 1
       K05036  SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
       K00274  MAO, aofH; monoamine oxidase [EC:1.4.3.4]
       K00545  COMT; catechol O-methyltransferase [EC:2.1.1.6]
     04726 Serotonergic synapse [PATH:ko04726]
     04720 Long-term potentiation [PATH:ko04720]
     04730 Long-term depression [PATH:ko04730]
     04723 Retrograde endocannabinoid signaling [PATH:ko04723]
     04721 Synaptic vesicle cycle [PATH:ko04721]
     04722 Neurotrophin signaling pathway [PATH:ko04722]
 
   Sensory system
 
   Development
     04320 Dorso-ventral axis formation [PATH:ko04320]
     04360 Axon guidance [PATH:ko04360]
     04380 Osteoclast differentiation [PATH:ko04380]
       K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
       K05090  CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K04364  GRB2; growth factor receptor-binding protein 2
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04687  IFNG; interferon gamma
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K11220  STAT1; signal transducer and activator of transcription 1
       K04383  IL1A; interleukin 1 alpha
       K04519  IL1B; interleukin 1 beta
       K04386  IL1R1; interleukin 1 receptor type I
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K03158  TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K05473  TNFSF11, RANKL; tumor necrosis factor ligand superfamily member 11
       K05147  TNFRSF11A, RANK; tumor necrosis factor receptor superfamily member 11A
       K05148  TNFRSF11B, OPG; tumor necrosis factor receptor superfamily member 11B
       K03173  TRAF2; TNF receptor-associated factor 2
       K03175  TRAF6; TNF receptor-associated factor 6
       K05856  LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
       K05703  FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]
       K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K09253  RELB; transcription factor RelB
       K04469  NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K04403  MAP3K7IP1, TAB1; TAK1-binding protein 1
       K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K04735  RELA; transcription factor p65
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K17332  NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2
       K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
       K05415  IFNB; interferon beta
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K04379  FOS; proto-oncogene protein c-fos
       K09029  FOSB; protein FosB
       K09030  FOSL2; fos-like antigen 2
       K04502  FOSL1; fos-like antigen 1
       K04448  JUN; transcription factor AP-1
       K04449  JUND; transcription factor jun-D
       K09028  JUNB; transcription factor jun-B
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K08008  NOX, GP91; NADPH oxidase
       K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
       K08010  NCF2, P67PHOX; neutrophil cytosolic factor 2
       K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
       K08012  NCF4, P40PHOX; neutrophil cytosolic factor 4
       K07370  BTK; Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]
       K07364  TEC; tyrosine-protein kinase Tec [EC:2.7.10.2]
       K14377  OSCAR; osteoclast-associated immunoglobulin-like receptor
       K06512  LILR; leukocyte immunoglobulin-like receptor
       K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
       K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc region receptor II-a
       K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc region receptor II-b
       K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc region receptor II-c
       K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
       K14378  TREM2; triggering receptor expressed on myeloid cells 2
       K06551  SIRPA_B1_G; signal-regulatory protein alpha/beta1/gamma
       K07992  TYROBP, DAP12; TYRO protein tyrosine kinase binding protein
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K07371  BLNK; B-cell linker protein
       K07361  LCP2; lymphocyte cytosolic protein 2
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K09438  SPI1; transcription factor PU.1
       K09455  MITF; microphthalmia-associated transcription factor
       K01371  CTSK; cathepsin K [EC:3.4.22.38]
       K14379  ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]
       K04576  CALCR; calcitonin receptor
       K06493  ITGB3; integrin beta 3
       K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
       K05130  IFNAR1; interferon receptor 1
       K05131  IFNAR2; interferon receptor 2
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K11219  TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
       K11221  STAT2; signal transducer and activator of transcription 2
       K04693  IRF9, ISGF3G, P48; interferon regulatory factor 9
       K04694  SOCS1, JAB; suppressor of cytokine signaling 1
       K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
       K08091  GAB2; growth factor receptor bound protein 2-associated protein 2
       K14380  FHL2; four and a half LIM domains protein 2
       K08601  CYLD, USLP2; ubiquitin thioesterase CYLD [EC:3.1.2.15]
       K14381  SQSTM1; sequestosome 1
 
   Environmental adaptation
     04710 Circadian rhythm [PATH:ko04710]
       K08959  CSNK1D; casein kinase 1, delta [EC:2.7.11.1]
       K08960  CSNK1E; casein kinase 1, epsilon [EC:2.7.11.1]
       K02633  PER; period circadian protein
       K02295  CRY; cryptochrome
       K02296  ARNTL, BMAL1, CYC; aryl hydrocarbon receptor nuclear translocator-like protein 1
       K02223  CLOCK, KAT13D; circadian locomoter output cycles kaput protein [EC:2.3.1.48]
       K09026  NPAS2; neuronal PAS domain-containing protein 2
       K03728  NR1D1; nuclear receptor subfamily 1 group D member 1
       K08532  NR1F1, RORA; RAR-related orphan receptor alpha
       K08533  NR1F2, RORB; RAR-related orphan receptor beta
       K08534  NR1F3, RORC; RAR-related orphan receptor gamma
       K03729  BHLHB2, DEC1; class B basic helix-loop-helix protein 2
       K03730  BHLHB3, DEC2; class B basic helix-loop-helix protein 3
       K03868  RBX1, ROC1; RING-box protein 1
       K03347  CUL1, CDC53; cullin 1
       K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
       K03362  FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
       K10269  FBXL3; F-box and leucine-rich repeat protein 3
       K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
       K07199  PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit
       K07200  PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
     04713 Circadian entrainment [PATH:ko04713]
       K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
       K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
       K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
       K05211  GRIN2C; glutamate receptor ionotropic, NMDA 2C
       K05212  GRIN2D; glutamate receptor ionotropic, NMDA 2D
       K02183  CALM; calmodulin
       K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
       K13240  NOS1; nitric-oxide synthase, brain [EC:1.14.13.39]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04445  MSK1, RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K04961  RYR1; ryanodine receptor 1
       K04962  RYR2; ryanodine receptor 2
       K04963  RYR3; ryanodine receptor 3
       K16513  NOS1AP, CAPON; carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
       K07843  RASD1; RAS, dexamethasone-induced Ras-related protein 1
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
       K04536  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
       K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
       K07825  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
       K04538  GNB4; guanine nucleotide-binding protein subunit beta-4
       K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
       K07826  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
       K04540  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
       K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
       K04542  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
       K04543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
       K04544  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
       K04545  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
       K04546  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K04547  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
       K04548  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
       K04549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
       K05197  GRIA1; glutamate receptor 1
       K05198  GRIA2; glutamate receptor 2
       K05199  GRIA3; glutamate receptor 3
       K05200  GRIA4; glutamate receptor 4
       K04854  CACNA1G; voltage-dependent calcium channel T type alpha-1G
       K04855  CACNA1H; voltage-dependent calcium channel T type alpha-1H
       K04856  CACNA1I; voltage-dependent calcium channel T type alpha-1I
       K04587  ADCYAP1R1, PACAPRI; pituitary adenylate cyclase-activating polypeptide type I receptor
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K11265  ADCY10; adenylate cyclase 10 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K12318  GUCY1A; guanylate cyclase soluble subunit alpha [EC:4.6.1.2]
       K12319  GUCY1B; guanylate cyclase soluble subunit beta [EC:4.6.1.2]
       K07376  PRKG; protein kinase, cGMP-dependent [EC:2.7.11.12]
       K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
       K04851  CACNA1D; voltage-dependent calcium channel L type alpha-1D
       K04286  MTNR1B; melatonin receptor type 1B
       K04285  MTNR1A; melatonin receptor type 1A
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
       K04997  KCNJ3; potassium inwardly-rectifying channel subfamily J member 3
       K04999  KCNJ5; potassium inwardly-rectifying channel subfamily J member 5
       K05000  KCNJ6; potassium inwardly-rectifying channel subfamily J member 6
       K05002  KCNJ9; potassium inwardly-rectifying channel subfamily J member 9
       K02633  PER; period circadian protein
       K04379  FOS; proto-oncogene protein c-fos
     04711 Circadian rhythm - fly [PATH:ko04711]
     04712 Circadian rhythm - plant [PATH:ko04712]
     04626 Plant-pathogen interaction [PATH:ko04626]
 
 Human Diseases
 
   Cancers
     05200 Pathways in cancer [PATH:ko05200]
     05202 Transcriptional misregulation in cancers [PATH:ko05202]
     05206 MicroRNAs in cancer [PATH:ko05206]
     05205 Proteoglycans in cancer [PATH:ko05205]
     05204 Chemical carcinogenesis [PATH:ko05204]
     05203 Viral carcinogenesis [PATH:ko05203]
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K10610  DDB1; DNA damage-binding protein 1
       K16197  YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
       K06630  YWHAE; 14-3-3 protein epsilon
       K16198  YWHAG_H; 14-3-3 protein gamma/eta
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K04692  STAT3; signal transducer and activator of transcription 3
       K11223  STAT5A; signal transducer and activator of transcription 5A
       K11224  STAT5B; signal transducer and activator of transcription 5B
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K08665  HPN; hepsin (transmembrane protease, serine 1) [EC:3.4.21.-]
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04735  RELA; transcription factor p65
       K09254  REL; c-Rel proto-oncogene protein
       K04469  NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04451  TP53, P53; tumor protein p53
       K06626  CCNE; cyclin E
       K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
       K12496  EGR2; early growth response protein 2
       K12497  EGR3; early growth response protein 3
       K15041  VDAC3; voltage-dependent anion channel protein 3
       K03159  TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3
       K15413  SP100; nuclear autoantigen Sp-100
       K12886  HNRNPK; heterogeneous nuclear ribonucleoprotein K
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K11594  DDX3X, bel; ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]
       K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K11252  H2B; histone H2B
       K11254  H4; histone H4
       K02159  BAX; apoptosis regulator BAX
       K04364  GRB2; growth factor receptor-binding protein 2
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K02087  CDK1, CDC2; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
       K03120  TBP, tbp; transcription initiation factor TFIID TATA-box-binding protein
       K11838  USP7, UBP15; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.1.2.15]
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
       K06053  RBPSUH, RBPJK; recombining binding protein suppressor of hairless
       K06063  SNW1, SKIIP, SKIP; SNW domain-containing protein 1
       K03141  TFIIH1, GTF2H1, TFB1; transcription initiation factor TFIIH subunit 1
       K03142  TFIIH2, GTF2H2, SSL1; transcription initiation factor TFIIH subunit 2
       K03143  TFIIH3, GTF2H3, TFB4; transcription initiation factor TFIIH subunit 3
       K03144  TFIIH4, GTF2H4, TFB2; transcription initiation factor TFIIH subunit 4
       K03136  TFIIE1, GTF2E1, TFA1, tfe; transcription initiation factor TFIIE subunit alpha
       K03137  TFIIE2, GTF2E2, TFA2; transcription initiation factor TFIIE subunit beta
       K15979  SND1; staphylococcal nuclease domain-containing protein 1
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K03124  TFIIB, GTF2B, SUA7, tfb; transcription initiation factor TFIIB
       K04503  CCND1; cyclin D1
       K10151  CCND2; cyclin D2
       K10152  CCND3; cyclin D3
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K06627  CCNA; cyclin A
       K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
       K16174  MRPS18B, MRPS18-2; small subunit ribosomal protein S18b, mitochondrial
       K03172  TRAF1; TNF receptor-associated factor 1
       K03173  TRAF2; TNF receptor-associated factor 2
       K03174  TRAF3; TNF receptor-associated factor 3
       K09849  TRAF5; TNF receptor-associated factor 5
       K11218  JAK3; Janus kinase 3 [EC:2.7.10.2]
       K05854  LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K02146  ATPeV0D, ATP6D; V-type H+-transporting ATPase subunit d
       K10587  UBE3A, E6AP; ubiquitin-protein ligase E3 A [EC:6.3.2.19]
       K12076  DLG1; disks large protein 1
       K16175  SCRIB; protein scribble
       K05760  PXN; paxillin
       K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
       K05411  IRF3; interferon regulatory factor 3
       K03062  PSMC1, RPT2; 26S proteasome regulatory subunit T2
       K06618  RB1; retinoblastoma-associated protein
       K04681  RBL1; retinoblastoma-like protein 1
       K16332  RBL2; retinoblastoma-like protein 2
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K10691  UBR4, ZUBR1; E3 ubiquitin-protein ligase UBR4 [EC:6.3.2.19]
       K04448  JUN; transcription factor AP-1
       K11643  CHD4, MI2B; chromodomain-helicase-DNA-binding protein 4 [EC:3.6.4.12]
       K06067  HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
       K11404  HDAC3; histone deacetylase 3 [EC:3.5.1.98]
       K11406  HDAC4_5; histone deacetylase 4/5 [EC:3.5.1.98]
       K11407  HDAC6_10; histone deacetylase 6/10 [EC:3.5.1.98]
       K11408  HDAC7; histone deacetylase 7 [EC:3.5.1.98]
       K11405  HDAC8; histone deacetylase 8 [EC:3.5.1.98]
       K11409  HDAC9; histone deacetylase 9 [EC:3.5.1.98]
       K11418  HDAC11; histone deacetylase 11 [EC:3.5.1.98]
       K00873  PK, pyk; pyruvate kinase [EC:2.7.1.40]
       K04693  IRF9, ISGF3G, P48; interferon regulatory factor 9
       K09504  DNAJA3; DnaJ homolog subfamily A member 3
       K06062  PCAF, KAT2, GCN5; histone acetyltransferase [EC:2.3.1.48]
       K03122  TFIIA1, GTF2A1, TOA1; transcription initiation factor TFIIA large subunit
       K03123  TFIIA2, GTF2A2, TOA2; transcription initiation factor TFIIA small subunit
       K04378  SRF; serum response factor
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K08053  RASA2, GAP1M; Ras GTPase-activating protein 2
       K04393  CDC42; cell division control protein 42
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K04513  RHOA; Ras homolog gene family, member A
       K05768  GSN; gelsolin
       K05699  ACTN; actinin alpha
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
       K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
       K02216  CHK1; serine/threonine-protein kinase Chk1 [EC:2.7.11.1]
       K03363  CDC20; cell division cycle 20, cofactor of APC complex
       K06638  MAD1L; mitotic spindle assembly checkpoint protein MAD1
       K15305  VAC14, TAX1BP2; vacuole morphology and inheritance protein 14
       K15306  RANBP1; Ran-binding protein 1
       K02330  POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
       K09447  IRF7; interferon regulatory factor 7
       K05060  IL6ST, GP130; interleukin 6 signal transducer
       K04180  CCR5; C-C chemokine receptor type 5
       K04183  CCR8; C-C chemokine receptor type 8
       K04178  CCR3; C-C chemokine receptor type 3
       K04179  CCR4; C-C chemokine receptor type 4
       K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K02158  BAD; BCL2-antagonist of cell death
       K10131  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
       K03990  C3; complement component 3
       K06751  MHC1; major histocompatibility complex, class I
     05210 Colorectal cancer [PATH:ko05210]
     05212 Pancreatic cancer [PATH:ko05212]
     05214 Glioma [PATH:ko05214]
     05216 Thyroid cancer [PATH:ko05216]
     05221 Acute myeloid leukemia [PATH:ko05221]
     05220 Chronic myeloid leukemia [PATH:ko05220]
     05217 Basal cell carcinoma [PATH:ko05217]
     05218 Melanoma [PATH:ko05218]
     05211 Renal cell carcinoma [PATH:ko05211]
     05219 Bladder cancer [PATH:ko05219]
     05215 Prostate cancer [PATH:ko05215]
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
       K06626  CCNE; cyclin E
       K06618  RB1; retinoblastoma-associated protein
       K17454  E2F1; transcription factor E2F1
       K09389  E2F2; transcription factor E2F2
       K06620  E2F3; transcription factor E2F3
       K04526  INS; insulin
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K05450  PDGFC_D; platelet derived growth factor C/D
       K04357  EGF; epidermal growth factor
       K08774  TGFA; transforming growth factor, alpha
       K05459  IGF1; insulin-like growth factor 1
       K05086  INSRR; insulin receptor-related receptor [EC:2.7.10.1]
       K04363  PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K04362  FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]
       K05093  FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]
       K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
       K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
       K05087  IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
       K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
       K09348  NKX3-1; homeobox protein Nkx-3.1
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K02158  BAD; BCL2-antagonist of cell death
       K07201  FOXO1; forkhead box protein O1
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
       K04451  TP53, P53; tumor protein p53
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K02105  CTNNB1; catenin beta 1
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K02620  TCF7; transcription factor 7
       K04490  TCF7L1; transcription factor 7-like 1
       K04491  TCF7L2; transcription factor 7-like 2
       K04492  LEF1; lymphoid enhancer-binding factor 1
       K04503  CCND1; cyclin D1
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K02161  BCL2; apoptosis regulator BCL-2
       K07203  FRAP; FKBP12-rapamycin complex-associated protein
       K04364  GRB2; growth factor receptor-binding protein 2
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K12344  SRD5A2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2 [EC:1.3.1.22]
       K08557  NR3C4, AR; androgen receptor
       K04079  htpG, HSP90A; molecular chaperone HtpG
       K09487  HSP90B, TRA1; heat shock protein 90kDa beta
       K01351  KLK3; semenogelase [EC:3.4.21.77]
     05213 Endometrial cancer [PATH:ko05213]
     05222 Small cell lung cancer [PATH:ko05222]
     05223 Non-small cell lung cancer [PATH:ko05223]
 
   Immune diseases
 
   Neurodegenerative diseases
     05010 Alzheimer's disease [PATH:ko05010]
     05012 Parkinson's disease [PATH:ko05012]
     05014 Amyotrophic lateral sclerosis (ALS) [PATH:ko05014]
     05016 Huntington's disease [PATH:ko05016]
       K04644  CLTA, LCA; clathrin light chain A
       K04645  CLTB, LCB; clathrin light chain B
       K04646  CLTC; clathrin heavy chain
       K04559  HIP1; huntingtin interacting protein 1
       K11824  AP2A; AP-2 complex subunit alpha
       K11825  AP2B1; AP-2 complex subunit beta-1
       K11826  AP2M1; AP-2 complex subunit mu-1
       K11827  AP2S1; AP-2 complex subunit sigma-1
       K04533  HD; huntingtin
       K04638  ESRRBL1, HIPPI; estrogen-related receptor beta like 1
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K04604  GRM5; metabotropic glutamate receptor 5
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
       K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K11828  DLG4, PSD95; discs large protein 4
       K05625  TGM2; transglutaminase 2 [EC:2.3.2.13]
       K09222  REST; RE1-silencing transcription factor
       K11644  SIN3A; paired amphipathic helix protein Sin3a
       K11829  RCOR1, COREST; REST corepressor 1
       K06067  HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
       K03006  RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
       K03010  RPB2, POLR2B; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
       K03011  RPB3, POLR2C; DNA-directed RNA polymerase II subunit RPB3
       K03012  RPB4, POLR2D; DNA-directed RNA polymerase II subunit RPB4
       K03013  RPB5, POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1
       K03014  RPB6, POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2
       K03015  RPB7, POLR2G; DNA-directed RNA polymerase II subunit RPB7
       K03016  RPB8, POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3
       K03017  RPB9, POLR2I; DNA-directed RNA polymerase II subunit RPB9
       K03007  RPB10, POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5
       K03008  RPB11, POLR2J; DNA-directed RNA polymerase II subunit RPB11
       K03009  RPB12, POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4
       K04355  BDNF; brain-derived neurotrophic factor
       K04648  DCTN1; dynactin 1
       K10424  DCTN2; dynactin 2
       K10426  DCTN4; dynactin 4
       K04647  HAP1; huntingtin-associated protein 1
       K10408  DNAH; dynein heavy chain, axonemal
       K10410  DNALI; dynein light intermediate chain, axonemal
       K10409  DNAI1; dynein intermediate chain 1, axonemal
       K11143  DNAI2; dynein intermediate chain 2, axonemal
       K10411  DNAL1; dynein light chain 1, axonemal
       K10412  DNAL4; dynein light chain 4, axonemal
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K03129  TAF4; transcription initiation factor TFIID subunit 4
       K03120  TBP, tbp; transcription initiation factor TFIID TATA-box-binding protein
       K04684  SP1; transcription factor Sp1
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K07202  PPARGC1A, PGC1A; alpha peroxisome proliferator-activated receptor gamma coactivator 1-alpha
       K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
       K11830  TFAM, MTTFA; transcription factor A, mitochondrial
       K11831  NRF1; nuclear respiratory factor 1
       K04565  SOD1; superoxide dismutase, Cu-Zn family [EC:1.15.1.1]
       K04564  SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]
       K08769  UCP1, SLC25A7; solute carrier family 25 (mitochondrial uncoupling protein), member 7
       K04451  TP53, P53; tumor protein p53
       K02159  BAX; apoptosis regulator BAX
       K10132  BBC3, PUMA; BCL2-binding component 3
       K03942  NDUFV1; NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:1.6.5.3 1.6.99.3]
       K03943  NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:1.6.5.3 1.6.99.3]
       K03944  NDUFV3; NADH dehydrogenase (ubiquinone) flavoprotein 3
       K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
       K03946  NDUFA2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2
       K03947  NDUFA3; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3
       K03948  NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4
       K03949  NDUFA5; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5
       K03950  NDUFA6; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6
       K03951  NDUFA7; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7
       K03952  NDUFA8; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8
       K03953  NDUFA9; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9
       K03954  NDUFA10; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10
       K03955  NDUFAB1; NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1
       K03956  NDUFA11; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11
       K11352  NDUFA12; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12
       K11353  NDUFA13; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13
       K03957  NDUFB1; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 1
       K03958  NDUFB2; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 2
       K03959  NDUFB3; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3
       K03960  NDUFB4; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4
       K03961  NDUFB5; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5
       K03962  NDUFB6; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6
       K03963  NDUFB7; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7
       K03964  NDUFB8; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8
       K03965  NDUFB9; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9
       K03966  NDUFB10; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10
       K11351  NDUFB11; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11
       K03934  NDUFS1; NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:1.6.5.3 1.6.99.3]
       K03935  NDUFS2; NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:1.6.5.3 1.6.99.3]
       K03936  NDUFS3; NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:1.6.5.3 1.6.99.3]
       K03937  NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4
       K03938  NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5
       K03939  NDUFS6; NADH dehydrogenase (ubiquinone) Fe-S protein 6
       K03940  NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:1.6.5.3 1.6.99.3]
       K03941  NDUFS8; NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:1.6.5.3 1.6.99.3]
       K03967  NDUFC1; NADH dehydrogenase (ubiquinone) 1 subunit C1
       K03968  NDUFC2; NADH dehydrogenase (ubiquinone) 1 subunit C2
       K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
       K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
       K00236  SDHC, SDH3; succinate dehydrogenase (ubiquinone) cytochrome b560 subunit
       K00237  SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit
       K00411  UQCRFS1, RIP1, petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:1.10.2.2]
       K00412  CYTB, petB; ubiquinol-cytochrome c reductase cytochrome b subunit
       K00413  CYC1, CYT1, petC; ubiquinol-cytochrome c reductase cytochrome c1 subunit
       K00414  QCR1, UQCRC1; ubiquinol-cytochrome c reductase core subunit 1
       K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
       K00416  QCR6, UQCRH; ubiquinol-cytochrome c reductase subunit 6
       K00417  QCR7, UQCRB; ubiquinol-cytochrome c reductase subunit 7
       K00418  QCR8, UQCRQ; ubiquinol-cytochrome c reductase subunit 8
       K00419  QCR9, UCRC; ubiquinol-cytochrome c reductase subunit 9
       K00420  QCR10, UQCR; ubiquinol-cytochrome c reductase subunit 10
       K02262  COX3; cytochrome c oxidase subunit 3
       K02256  COX1; cytochrome c oxidase subunit 1 [EC:1.9.3.1]
       K02261  COX2; cytochrome c oxidase subunit 2
       K02263  COX4; cytochrome c oxidase subunit 4
       K02264  COX5A; cytochrome c oxidase subunit 5a
       K02265  COX5B; cytochrome c oxidase subunit 5b
       K02266  COX6A; cytochrome c oxidase subunit 6a
       K02267  COX6B; cytochrome c oxidase subunit 6b
       K02268  COX6C; cytochrome c oxidase subunit 6c
       K02270  COX7A; cytochrome c oxidase subunit 7a
       K02271  COX7B; cytochrome c oxidase subunit 7b
       K02272  COX7C; cytochrome c oxidase subunit 7c
       K02273  COX8; cytochrome c oxidase subunit 8
       K02132  ATPeF1A, ATP5A1, ATP1; F-type H+-transporting ATPase subunit alpha
       K02133  ATPeF1B, ATP5B, ATP2; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14]
       K02136  ATPeF1G, ATP5C1, ATP3; F-type H+-transporting ATPase subunit gamma
       K02134  ATPeF1D, ATP5D, ATP16; F-type H+-transporting ATPase subunit delta
       K02135  ATPeF1E, ATP5E, ATP15; F-type H+-transporting ATPase subunit epsilon
       K02126  ATPeF0A, MTATP6, ATP6; F-type H+-transporting ATPase subunit a
       K02127  ATPeF0B, ATP5F1, ATP4; F-type H+-transporting ATPase subunit b
       K02128  ATPeF0C, ATP5G, ATP9; F-type H+-transporting ATPase subunit c
       K02138  ATPeF0D, ATP5H, ATP7; F-type H+-transporting ATPase subunit d
       K02137  ATPeF0O, ATP5O, ATP5; F-type H+-transporting ATPase subunit O
       K02131  ATPeF0F6, ATP5J; F-type H+-transporting ATPase subunit 6
       K02125  ATPeF08, MTATP8, ATP8; F-type H+-transporting ATPase subunit 8
       K05862  VDAC1; voltage-dependent anion channel protein 1
       K15040  VDAC2; voltage-dependent anion channel protein 2
       K15041  VDAC3; voltage-dependent anion channel protein 3
       K05863  SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31
       K09565  PPIF; peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]
       K08738  CYC; cytochrome c
       K02084  APAF1; apoptotic protease-activating factor
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
     05020 Prion diseases [PATH:ko05020]
 
   Substance dependence
     05030 Cocaine addiction [PATH:ko05030]
       K00501  TH; tyrosine 3-monooxygenase [EC:1.14.16.2]
       K01593  DDC; aromatic-L-amino-acid decarboxylase [EC:4.1.1.28]
       K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
       K00274  MAO, aofH; monoamine oxidase [EC:1.4.3.4]
       K05036  SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
       K04144  DRD1; dopamine receptor D1
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K04605  GRM2_3; metabotropic glutamate receptor 2/3
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K04145  DRD2; dopamine receptor D2
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K15839  GPSM1, AGS3; G-protein signaling modulator 1
       K13765  RGS9; regulator of G-protein signaling 9
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K15840  PDYN, PENKB; prodynorphin
       K04355  BDNF; brain-derived neurotrophic factor
       K04448  JUN; transcription factor AP-1
       K09029  FOSB; protein FosB
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K02090  CDK5; cyclin-dependent kinase 5 [EC:2.7.11.22]
       K11716  CDK5R1; cyclin-dependent kinase 5 activator 1
       K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
       K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
       K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
       K05211  GRIN2C; glutamate receptor ionotropic, NMDA 2C
       K05212  GRIN2D; glutamate receptor ionotropic, NMDA 2D
       K05213  GRIN3A; glutamate receptor ionotropic, NMDA 3A
       K05214  GRIN3B; glutamate receptor ionotropic, NMDA 3B
       K11828  DLG4, PSD95; discs large protein 4
       K15494  PPP1R1B, DARPP32; protein phosphatase 1 regulatory subunit 1B
       K05198  GRIA2; glutamate receptor 2
     05031 Amphetamine addiction [PATH:ko05031]
       K00501  TH; tyrosine 3-monooxygenase [EC:1.14.16.2]
       K01593  DDC; aromatic-L-amino-acid decarboxylase [EC:4.1.1.28]
       K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
       K00274  MAO, aofH; monoamine oxidase [EC:1.4.3.4]
       K05036  SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
       K04850  CACNA1C; voltage-dependent calcium channel L type alpha-1C
       K04851  CACNA1D; voltage-dependent calcium channel L type alpha-1D
       K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
       K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
       K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
       K05211  GRIN2C; glutamate receptor ionotropic, NMDA 2C
       K05212  GRIN2D; glutamate receptor ionotropic, NMDA 2D
       K05213  GRIN3A; glutamate receptor ionotropic, NMDA 3A
       K05214  GRIN3B; glutamate receptor ionotropic, NMDA 3B
       K05197  GRIA1; glutamate receptor 1
       K05198  GRIA2; glutamate receptor 2
       K05199  GRIA3; glutamate receptor 3
       K05200  GRIA4; glutamate receptor 4
       K04144  DRD1; dopamine receptor D1
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
       K04560  STX1A; syntaxin 1A
       K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
       K02183  CALM; calmodulin
       K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K15494  PPP1R1B, DARPP32; protein phosphatase 1 regulatory subunit 1B
       K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K15840  PDYN, PENKB; prodynorphin
       K15867  ARC; activity-regulated cytoskeleton-associated protein
       K04379  FOS; proto-oncogene protein c-fos
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K04448  JUN; transcription factor AP-1
       K09029  FOSB; protein FosB
       K11411  SIRT1, SIR2L1; NAD-dependent deacetylase sirtuin 1 [EC:3.5.1.-]
     05032 Morphine addiction [PATH:ko05032]
     05033 Nicotine addiction [PATH:ko05033]
     05034 Alcoholism [PATH:ko05034]
       K00501  TH; tyrosine 3-monooxygenase [EC:1.14.16.2]
       K01593  DDC; aromatic-L-amino-acid decarboxylase [EC:4.1.1.28]
       K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
       K00274  MAO, aofH; monoamine oxidase [EC:1.4.3.4]
       K05036  SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
       K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
       K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
       K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
       K05211  GRIN2C; glutamate receptor ionotropic, NMDA 2C
       K05212  GRIN2D; glutamate receptor ionotropic, NMDA 2D
       K05213  GRIN3A; glutamate receptor ionotropic, NMDA 3A
       K05214  GRIN3B; glutamate receptor ionotropic, NMDA 3B
       K06067  HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
       K11404  HDAC3; histone deacetylase 3 [EC:3.5.1.98]
       K11406  HDAC4_5; histone deacetylase 4/5 [EC:3.5.1.98]
       K11407  HDAC6_10; histone deacetylase 6/10 [EC:3.5.1.98]
       K11408  HDAC7; histone deacetylase 7 [EC:3.5.1.98]
       K11405  HDAC8; histone deacetylase 8 [EC:3.5.1.98]
       K11409  HDAC9; histone deacetylase 9 [EC:3.5.1.98]
       K11418  HDAC11; histone deacetylase 11 [EC:3.5.1.98]
       K11251  H2A; histone H2A
       K11252  H2B; histone H2B
       K11253  H3; histone H3
       K11254  H4; histone H4
       K11303  HAT1, KAT1; histone acetyltransferase 1 [EC:2.3.1.48]
       K04144  DRD1; dopamine receptor D1
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K04145  DRD2; dopamine receptor D2
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
       K04536  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
       K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
       K07825  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
       K04538  GNB4; guanine nucleotide-binding protein subunit beta-4
       K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
       K07826  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
       K04540  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
       K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
       K04542  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
       K04543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
       K04544  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
       K04545  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
       K04546  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
       K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
       K04547  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
       K04548  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
       K04549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
       K04266  ADORA2A, ADOR; adenosine receptor A2a
       K04267  ADORA2B; adenosine receptor A2b
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K05256  CRH; corticotropin-releasing hormone
       K05232  NPY; neuropeptide Y
       K04355  BDNF; brain-derived neurotrophic factor
       K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]
       K06279  SHC1; SHC- transforming protein 1
       K17447  SHC2; SHC- transforming protein 2
       K17448  SHC3; SHC- transforming protein 3
       K17449  SHC4; SHC- transforming protein 4
       K04364  GRB2; growth factor receptor-binding protein 2
       K03099  SOS; son of sevenless
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K15840  PDYN, PENKB; prodynorphin
       K02183  CALM; calmodulin
       K07359  CAMKK; calcium/calmodulin-dependent protein kinase kinase [EC:2.7.11.17]
       K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]
       K09029  FOSB; protein FosB
       K15494  PPP1R1B, DARPP32; protein phosphatase 1 regulatory subunit 1B
       K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
       K15985  PKIA; cAMP-dependent protein kinase inhibitor alpha
 
   Cardiovascular diseases
 
   Endocrine and metabolic diseases
 
   Infectious diseases
     05110 Vibrio cholerae infection [PATH:ko05110]
     05111 Vibrio cholerae pathogenic cycle [PATH:ko05111]
     05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
     05130 Pathogenic Escherichia coli infection [PATH:ko05130]
     05132 Salmonella infection [PATH:ko05132]
     05131 Shigellosis [PATH:ko05131]
     05133 Pertussis [PATH:ko05133]
     05134 Legionellosis [PATH:ko05134]
     05150 Staphylococcus aureus infection [PATH:ko05150]
     05152 Tuberculosis [PATH:ko05152]
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K03158  TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K04400  CASP10; caspase 10 [EC:3.4.22.63]
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K04726  BID; BH3 interacting domain death agonist
       K02159  BAX; apoptosis regulator BAX
       K08738  CYC; cytochrome c
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K02084  APAF1; apoptotic protease-activating factor
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K02158  BAD; BCL2-antagonist of cell death
       K02161  BCL2; apoptosis regulator BCL-2
       K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
       K04687  IFNG; interferon gamma
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
       K11220  STAT1; signal transducer and activator of transcription 1
       K08060  CIITA; class II, major histocompatibility complex, transactivator
       K08061  RFX5; regulatory factor X 5
       K08062  RFXANK; regulatory factor X-associated ankyrin-containing protein
       K08063  RFXAP; regulatory factor X-associated protein
       K08064  NFYA; nuclear transcription factor Y, alpha
       K08065  NFYB; nuclear transcription Y subunit beta
       K08066  NFYC; nuclear transcription factor Y, gamma
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K06752  MHC2; major histocompatibility complex, class II
       K06505  CD74, DHLAG; CD74 antigen
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K05443  IL10, CSIF; interleukin 10
       K05134  IL10RA; interleukin 10 receptor alpha
       K05135  IL10RB; interleukin 10 receptor beta
       K01368  CTSS; cathepsin S [EC:3.4.22.27]
       K10059  CLEC4E; C-type lectin domain family 4 member E
       K07983  FCER1G; Fc receptor, IgE, high affinity I, gamma polypeptide
       K10074  CLEC7A; C-type lectin domain family 7 member A
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K12794  CARD9; caspase recruitment domain-containing protein 9
       K07369  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
       K07368  BCL10; B-cell CLL/lymphoma 10
       K14952  namH; UDP-MurNAc hydroxylase
       K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
       K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]
       K14953  lpqH; ipoprotein LpqH
       K14954  lprG; lipoprotein LprG
       K14955  lprA; lipoprotein LprA
       K02040  pstS; phosphate transport system substrate-binding protein
       K04043  dnaK; molecular chaperone DnaK
       K04077  groEL, HSPD1; chaperonin GroEL
       K14956  esxA, esat6; 6 kDa early secretory antigenic target
       K05399  LBP; lipopolysaccharide-binding protein
       K10159  TLR2; toll-like receptor 2
       K05398  TLR1; toll-like receptor 1
       K10169  TLR6; toll-like receptor 6
       K10160  TLR4; toll-like receptor 4
       K04391  CD14; CD14 antigen
       K05403  TIRAP; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K04730  IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
       K04731  IRAK2; interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1]
       K03175  TRAF6; TNF receptor-associated factor 6
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
       K05405  IL6; interleukin 6
       K05406  IL12A; interleukin 12A
       K05425  IL12B; interleukin 12B
       K05482  IL18, IL1F4; interleukin 18
       K05426  IL23A; interleukin 23, alpha subunit p19
       K04383  IL1A; interleukin 1 alpha
       K04519  IL1B; interleukin 1 beta
       K10048  CEBPB; CCAAT/enhancer binding protein (C/EBP), beta
       K10049  CEBPG; CCAAT/enhancer binding protein (C/EBP), gamma
       K10161  TLR9; toll-like receptor 9
       K05414  IFNA; interferon alpha
       K05415  IFNB; interferon beta
       K06563  CD209; CD209 antigen
       K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
       K04513  RHOA; Ras homolog gene family, member A
       K14957  LSP1; lymphocyte-specific protein 1
       K08862  PLK3, CNK; polo-like kinase 3 [EC:2.7.11.21]
       K14958  KSR1; kinase suppressor of Ras 1
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K07438  CYP27B; 25-hydroxyvitamin D3 1alpha-hydroxylase [EC:1.14.13.13]
       K08539  NR1I1, VDR; vitamin D3 receptor
       K13916  CAMP, LL37; cathelicidin antimicrobial peptide
       K03990  C3; complement component 3
       K04011  CR1, CD35; complement component (3b/4b) receptor 1
       K06462  ITGAX; integrin alpha X
       K06464  ITGB2; integrin beta 2
       K06461  ITGAM; integrin alpha M
       K06560  MRC; mannose receptor, C type
       K04718  SPHK; sphingosine kinase [EC:2.7.1.91]
       K02183  CALM; calmodulin
       K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
       K07887  RAB5A; Ras-related protein Rab-5A
       K07888  RAB5B; Ras-related protein Rab-5B
       K07889  RAB5C; Ras-related protein Rab-5C
       K12478  EEA1; early endosome antigen 1
       K07897  RAB7A; Ras-related protein Rab-7A
       K01379  CTSD; cathepsin D [EC:3.4.23.5]
       K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
       K02146  ATPeV0D, ATP6D; V-type H+-transporting ATPase subunit d
       K02144  ATPeV1H; V-type H+-transporting ATPase subunit H
       K03662  ATPeVS1, ATP6S1; V-type H+-transporting ATPase S1 subunit
       K02155  ATPeV0C, ATP6L; V-type H+-transporting ATPase 16kDa proteolipid subunit
       K03661  ATPeV0B, ATP6F; V-type H+-transporting ATPase 21kDa proteolipid subunit
       K06528  LAMP1_2, CD107; lysosomal-associated membrane protein 1/2
       K01078  E3.1.3.2; acid phosphatase [EC:3.1.3.2]
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K13882  CORO1A; coronin-1A
       K14949  pknG; serine/threonine-protein kinase PknG [EC:2.7.11.1]
       K06856  IGH; immunoglobulin heavy chain
       K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
       K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc region receptor II-a
       K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc region receptor II-b
       K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc region receptor II-c
       K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
     05100 Bacterial invasion of epithelial cells [PATH:ko05100]
     05166 HTLV-I infection [PATH:ko05166]
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K07299  SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
       K06724  NRP1; neuropilin 1
       K06527  VCAM1; vascular cell adhesion molecule 1
       K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
       K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
       K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
       K06490  ICAM1; intercellular adhesion molecule 1
       K05718  ITGAL; integrin alpha L
       K06464  ITGB2; integrin beta 2
       K06271  TLN; talin
       K04377  MYC; Myc proto-oncogene protein
       K08874  TRRAP; transformation/transcription domain-associated protein
       K11304  TIP60, KAT5, ESA1; histone acetyltransferase HTATIP [EC:2.3.1.48]
       K10151  CCND2; cyclin D2
       K15304  RANBP3; Ran-binding protein 3
       K07936  RAN; GTP-binding nuclear protein Ran
       K14290  XPO1, CRM1; exportin-1
       K06751  MHC1; major histocompatibility complex, class I
       K08057  CALR; calreticulin
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
       K17332  NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2
       K17333  NFATC3, NFAT4; nuclear factor of activated T-cells, cytoplasmic 3
       K17334  NFATC4, NFAT3; nuclear factor of activated T-cells, cytoplasmic 4
       K08054  CANX; calnexin
       K05069  IL2RB; interleukin 2 receptor beta
       K05070  IL2RG; interleukin 2 receptor gamma
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K11218  JAK3; Janus kinase 3 [EC:2.7.10.2]
       K11223  STAT5A; signal transducer and activator of transcription 5A
       K11224  STAT5B; signal transducer and activator of transcription 5B
       K00787  FDPS; farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K07829  RRAS; Ras-related protein R-Ras
       K07830  RRAS2, TC21; Ras-related protein R-Ras2
       K07831  MRAS; Ras-related protein M-Ras
       K05862  VDAC1; voltage-dependent anion channel protein 1
       K05863  SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31
       K15040  VDAC2; voltage-dependent anion channel protein 2
       K15041  VDAC3; voltage-dependent anion channel protein 3
       K05770  BZRP; benzodiazapine receptor
       K15305  VAC14, TAX1BP2; vacuole morphology and inheritance protein 14
       K15306  RANBP1; Ran-binding protein 1
       K06679  MAD1; mitotic spindle assembly checkpoint protein MAD1
       K02537  MAD2; mitotic spindle assembly checkpoint protein MAD2
       K06637  BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [EC:2.7.11.1]
       K02180  BUB3; cell cycle arrest protein BUB3
       K03363  CDC20; cell division cycle 20, cofactor of APC complex
       K03348  APC1; anaphase-promoting complex subunit 1
       K03349  APC2; anaphase-promoting complex subunit 2
       K03350  APC3, CDC27; anaphase-promoting complex subunit 3
       K03351  APC4; anaphase-promoting complex subunit 4
       K03352  APC5; anaphase-promoting complex subunit 5
       K03353  APC6, CDC16; anaphase-promoting complex subunit 6
       K03354  APC7; anaphase-promoting complex subunit 7
       K03355  APC8, CDC23; anaphase-promoting complex subunit 8
       K03356  APC9; anaphase-promoting complex subunit 9
       K03357  APC10, DOC1; anaphase-promoting complex subunit 10
       K03358  APC11; anaphase-promoting complex subunit 11
       K03359  APC12, CDC26; anaphase-promoting complex subunit 12
       K12416  SWM1, APC13; anaphase-promoting complex subunit SWM1
       K06635  PTTG; securin
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K04802  PCNA; proliferating cell nuclear antigen
       K02327  POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
       K02328  POLD2; DNA polymerase delta subunit 2
       K03504  POLD3; DNA polymerase delta subunit 3
       K03505  POLD4; DNA polymerase delta subunit 4
       K02324  POLE1; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
       K02325  POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
       K02326  POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
       K03506  POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
       K04503  CCND1; cyclin D1
       K10152  CCND3; cyclin D3
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K06618  RB1; retinoblastoma-associated protein
       K17454  E2F1; transcription factor E2F1
       K09389  E2F2; transcription factor E2F2
       K06620  E2F3; transcription factor E2F3
       K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
       K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
       K03209  WNT1; wingless-type MMTV integration site family, member 1
       K00182  WNT2; wingless-type MMTV integration site family, member 2
       K00312  WNT3; wingless-type MMTV integration site family, member 3
       K00408  WNT4; wingless-type MMTV integration site family, member 4
       K00444  WNT5; wingless-type MMTV integration site family, member 5
       K00445  WNT6; wingless-type MMTV integration site family, member 6
       K00572  WNT7; wingless-type MMTV integration site family, member 7
       K00714  WNT8; wingless-type MMTV integration site family, member 8
       K01064  WNT9; wingless-type MMTV integration site family, member 9
       K01357  WNT10; wingless-type MMTV integration site family, member 10
       K01384  WNT11; wingless-type MMTV integration site family, member 11
       K01558  WNT16; wingless-type MMTV integration site family, member 16
       K02432  FZD1_7, fz; frizzled 1/7
       K02235  FZD2; frizzled 2
       K02329  FZD3; frizzled 3
       K02354  FZD4, fz4; frizzled 4
       K02375  FZD5_8, fz2; frizzled 5/8
       K02376  FZD6; frizzled 6
       K02842  FZD9_10; frizzled 9/10
       K04690  FZDN, fz3; frizzled
       K02353  DVL; segment polarity protein dishevelled
       K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
       K02105  CTNNB1; catenin beta 1
       K02085  APC; adenomatosis polyposis coli protein
       K12076  DLG1; disks large protein 1
       K04359  PDGFA; platelet-derived growth factor subunit A
       K17386  PDGFB; platelet-derived growth factor subunit B
       K04363  PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
       K05089  PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K03158  TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
       K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
       K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
       K04448  JUN; transcription factor AP-1
       K15307  GPS2; G protein pathway suppressor 2
       K04386  IL1R1; interleukin 1 receptor type I
       K04387  IL1R2; interleukin 1 receptor type II
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K03159  TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3
       K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
       K05151  TNFRSF13C, BAFFR; tumor necrosis factor receptor superfamily member 13C
       K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
       K09253  RELB; transcription factor RelB
       K04469  NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
       K05429  IL2; interleukin 2
       K05068  IL2RA, CD25; interleukin 2 receptor alpha
       K05433  IL15; interleukin 15
       K05074  IL15RA; interleukin 15 receptor alpha
       K05405  IL6; interleukin 6
       K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
       K05468  LTA, TNFB; lymphotoxin alpha (TNF superfamily, member 1)
       K04570  BCL2L1, bcl-xL; BCL2-like 1 (apoptosis regulator Bcl-X)
       K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP
       K15308  TTP; tristetraprolin
       K08065  NFYB; nuclear transcription Y subunit beta
       K06752  MHC2; major histocompatibility complex, class II
       K04378  SRF; serum response factor
       K04376  ELK4, SAP1; ETS domain-containing protein Elk-4
       K04375  ELK1; ETS domain-containing protein Elk-1
       K09438  SPI1; transcription factor PU.1
       K02678  ETS, pnt; c-ets proto-oncogene protein
       K03120  TBP, tbp; transcription initiation factor TFIID TATA-box-binding protein
       K04379  FOS; proto-oncogene protein c-fos
       K09203  EGR1; early growth response protein 1
       K12496  EGR2; early growth response protein 2
       K04502  FOSL1; fos-like antigen 1
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K09052  CREM; cAMP response element modulator
       K09053  ATF1; activating transcription factor 1
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K09032  ATF3, LRF1; activating transcription factor 3
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09027  XBP1; X box-binding protein 1
       K15309  CRTC1, TORC1; CREB-regulated transcription coactivator 1
       K16333  CRTC2, TORC2; CREB-regulated transcription coactivator 2
       K16334  CRTC3, TORC3; CREB-regulated transcription coactivator 3
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K06062  PCAF, KAT2, GCN5; histone acetyltransferase [EC:2.3.1.48]
       K09063  TCF3, E2A; transcription factor E2-alpha
       K02330  POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
       K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
       K05856  LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
       K11126  TERT, EST2; telomerase reverse transcriptase [EC:2.7.7.49]
       K09420  MYB; myb proto-oncogene protein
       K09421  MYBL; myb-related protein
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
       K04501  SMAD4; mothers against decapentaplegic homolog 4
       K04728  ATM, TEL1; ataxia telangiectasia mutated family protein [EC:2.7.11.1]
       K06640  ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
       K02216  CHK1; serine/threonine-protein kinase Chk1 [EC:2.7.11.1]
       K06641  CHK2; serine/threonine-protein kinase Chk2 [EC:2.7.11.1]
       K04451  TP53, P53; tumor protein p53
       K02159  BAX; apoptosis regulator BAX
       K15310  TP53INP1; tumor protein p53-inducible nuclear protein 1
       K09341  MSX; homeobox protein MSX
     05162 Measles [PATH:ko05162]
     05164 Influenza A [PATH:ko05164]
     05161 Hepatitis B [PATH:ko05161]
       K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
       K04377  MYC; Myc proto-oncogene protein
       K12496  EGR2; early growth response protein 2
       K12497  EGR3; early growth response protein 3
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K04389  TNFSF6, FASL; tumor necrosis factor ligand superfamily member 6
       K04390  TNFRSF6, FAS; tumor necrosis factor receptor superfamily member 6
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K04400  CASP10; caspase 10 [EC:3.4.22.63]
       K10610  DDB1; DNA damage-binding protein 1
       K10140  DDB2; DNA damage-binding protein 2
       K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
       K16197  YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
       K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K01403  MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
       K02161  BCL2; apoptosis regulator BCL-2
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K02158  BAD; BCL2-antagonist of cell death
       K04451  TP53, P53; tumor protein p53
       K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
       K04741  CASP12; caspase 12 [EC:3.4.22.-]
       K02084  APAF1; apoptotic protease-activating factor
       K16344  HBXIP; hepatitis B virus X-interacting protein
       K08731  BIRC5; baculoviral IAP repeat-containing protein 5
       K02159  BAX; apoptosis regulator BAX
       K08738  CYC; cytochrome c
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K15041  VDAC3; voltage-dependent anion channel protein 3
       K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
       K17332  NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2
       K17333  NFATC3, NFAT4; nuclear factor of activated T-cells, cytoplasmic 3
       K17334  NFATC4, NFAT3; nuclear factor of activated T-cells, cytoplasmic 4
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K05871  PTK2B, FAK2; focal adhesion kinase 2 [EC:2.7.10.2]
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K04364  GRB2; growth factor receptor-binding protein 2
       K02833  HRAS; GTPase HRas
       K07827  KRAS, KRAS2; GTPase KRas
       K07828  NRAS; GTPase NRas
       K04448  JUN; transcription factor AP-1
       K04501  SMAD4; mothers against decapentaplegic homolog 4
       K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
       K10030  IL8, CXCL8; interleukin 8
       K04802  PCNA; proliferating cell nuclear antigen
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K11220  STAT1; signal transducer and activator of transcription 1
       K11221  STAT2; signal transducer and activator of transcription 2
       K04692  STAT3; signal transducer and activator of transcription 3
       K11222  STAT4; signal transducer and activator of transcription 4
       K11223  STAT5A; signal transducer and activator of transcription 5A
       K11224  STAT5B; signal transducer and activator of transcription 5B
       K11225  STAT6; signal transducer and activator of transcription 6
       K03662  ATPeVS1, ATP6S1; V-type H+-transporting ATPase S1 subunit
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K09048  CREB3; cyclic AMP-responsive element-binding protein 3
       K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
       K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
       K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
       K04379  FOS; proto-oncogene protein c-fos
       K04375  ELK1; ETS domain-containing protein Elk-1
       K11594  DDX3X, bel; ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]
       K05414  IFNA; interferon alpha
       K05130  IFNAR1; interferon receptor 1
       K05401  TLR3; toll-like receptor 3
       K05842  TRIF; toll-like receptor adapter molecule 1
       K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58 [EC:3.6.3.14]
       K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13]
       K12648  MAVS, IPS1; mitochondrial antiviral-signaling protein
       K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
       K05410  TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
       K05411  IRF3; interferon regulatory factor 3
       K09447  IRF7; interferon regulatory factor 7
       K10160  TLR4; toll-like receptor 4
       K05409  TIRP, TRAM; TRIF-related adaptor molecule
       K05415  IFNB; interferon beta
       K10159  TLR2; toll-like receptor 2
       K05403  TIRAP; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K05405  IL6; interleukin 6
       K04503  CCND1; cyclin D1
       K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
       K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
       K06618  RB1; retinoblastoma-associated protein
       K17454  E2F1; transcription factor E2F1
       K09389  E2F2; transcription factor E2F2
       K06620  E2F3; transcription factor E2F3
       K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
       K06626  CCNE; cyclin E
       K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
       K06627  CCNA; cyclin A
     05160 Hepatitis C [PATH:ko05160]
     05168 Herpes simplex infection [PATH:ko05168]
     05169 Epstein-Barr virus infection [PATH:ko05169]
     05146 Amoebiasis [PATH:ko05146]
     05144 Malaria [PATH:ko05144]
     05145 Toxoplasmosis [PATH:ko05145]
     05140 Leishmaniasis [PATH:ko05140]
     05142 Chagas disease (American trypanosomiasis) [PATH:ko05142]
     05143 African trypanosomiasis [PATH:ko05143]
 
   Drug resistance

[ BRITE | KEGG2 | KEGG ]
Last updated: August 31, 2014