KEGG Orthology (KO)

[ Brite menu | Organism menu | Download htext ]
    

1st Level  2nd Level  3rd Level  4th Level 

 Metabolism
 
 Genetic Information Processing
 
 Environmental Information Processing
 
 Cellular Processes
 
   Transport and catabolism
     04144 Endocytosis [PATH:ko04144]
     04147 Exosome [BR:ko04147]
     04145 Phagosome [PATH:ko04145]
       K13505  VAMP3; vesicle-associated membrane protein 3
       K13813  STX12, STX13; syntaxin 12/13
       K08488  STX7; syntaxin 7
       K05692  ACTB_G1; actin beta/gamma 1
       K13882  CORO1A; coronin-1A
       K08492  STX18; syntaxin 18
       K08517  SEC22; vesicle transport protein SEC22
       K06751  MHC1; major histocompatibility complex, class I
       K06752  MHC2; major histocompatibility complex, class II
       K07887  RAB5A; Ras-related protein Rab-5A
       K07888  RAB5B; Ras-related protein Rab-5B
       K07889  RAB5C; Ras-related protein Rab-5C
       K12478  EEA1; early endosome antigen 1
       K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
       K06503  TFRC, CD71; transferrin receptor
       K12182  HGS, HRS, VPS27; hepatocyte growth factor-regulated tyrosine kinase substrate
       K02145  ATPeV1A, ATP6A; V-type H+-transporting ATPase subunit A [EC:3.6.3.14]
       K02147  ATPeV1B, ATP6B; V-type H+-transporting ATPase subunit B
       K02148  ATPeV1C, ATP6C; V-type H+-transporting ATPase subunit C
       K02149  ATPeV1D, ATP6M; V-type H+-transporting ATPase subunit D
       K02150  ATPeV1E, ATP6E; V-type H+-transporting ATPase subunit E
       K02151  ATPeV1F, ATP6S14; V-type H+-transporting ATPase subunit F
       K02152  ATPeV1G, ATP6G; V-type H+-transporting ATPase subunit G
       K02153  ATPeV0E, ATP6H; V-type H+-transporting ATPase subunit e
       K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
       K02146  ATPeV0D, ATP6D; V-type H+-transporting ATPase subunit d
       K02144  ATPeV1H; V-type H+-transporting ATPase subunit H
       K02155  ATPeV0C, ATP6L; V-type H+-transporting ATPase 16kDa proteolipid subunit
       K03661  ATPeV0B, ATP6F; V-type H+-transporting ATPase 21kDa proteolipid subunit
       K03662  ATPeVS1, ATP6S1; V-type H+-transporting ATPase S1 subunit
       K07897  RAB7A; Ras-related protein Rab-7A
       K07898  RAB7B; Ras-related protein Rab-7B
       K13883  RILP; Rab-interacting lysosomal protein
       K10413  DYNC1H; dynein heavy chain 1, cytosolic
       K10414  DYNC2H, DNCH2; dynein heavy chain 2, cytosolic
       K10415  DYNC1I, DNCI; dynein intermediate chain, cytosolic
       K10416  DYNC1LI, DNCLI; dynein light intermediate chain 1, cytosolic
       K07374  TUBA; tubulin alpha
       K07375  TUBB; tubulin beta
       K06528  LAMP1_2, CD107; lysosomal-associated membrane protein 1/2
       K00921  PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
       K10089  M6PR; cation-dependent mannose-6-phosphate receptor
       K13240  NOS1; nitric-oxide synthase, brain [EC:1.14.13.39]
       K10789  MPO; myeloperoxidase [EC:1.11.2.2]
       K01365  CTSL; cathepsin L [EC:3.4.22.15]
       K01368  CTSS; cathepsin S [EC:3.4.22.27]
       K10956  SEC61A; protein transport protein SEC61 subunit alpha
       K09481  SEC61B, SBH2; protein transport protein SEC61 subunit beta
       K07342  SEC61G, SSS1, secE; protein transport protein SEC61 subunit gamma and related proteins
       K05653  ABCB2, TAP1; ATP-binding cassette, subfamily B (MDR/TAP), member 2
       K05654  ABCB3, TAP2; ATP-binding cassette, subfamily B (MDR/TAP), member 3
       K08057  CALR; calreticulin
       K08054  CANX; calnexin
       K06513  FCAR, CD89; CD89 antigen
       K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
       K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc region receptor II-a
       K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc region receptor II-b
       K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc region receptor II-c
       K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
       K06856  IGH; immunoglobulin heavy chain
       K01330  C1R; complement component 1, r subcomponent [EC:3.4.21.41]
       K06461  ITGAM; integrin alpha M
       K06464  ITGB2; integrin beta 2
       K03990  C3; complement component 3
       K10066  COLEC11; collectin sub-family member 11
       K10062  COLEC12; collectin sub-family member 12
       K03991  MBL; mannose-binding lectin
       K10067  SFTPA; pulmonary surfactant-associated protein A
       K10068  SFTPD, SFTP4; pulmonary surfactant-associated protein D
       K06487  ITGAV; integrin alpha V
       K06481  ITGA2; integrin alpha 2
       K06484  ITGA5; integrin alpha 5
       K05719  ITGB1; integrin beta 1
       K06493  ITGB3; integrin beta 3
       K06588  ITGB5; integrin beta 5
       K16857  THBS1; thrombospondin 1
       K04659  THBS2S; thrombospondin 2/3/4/5
       K10159  TLR2; toll-like receptor 2
       K10169  TLR6; toll-like receptor 6
       K10160  TLR4; toll-like receptor 4
       K04391  CD14; CD14 antigen
       K06560  MRC; mannose receptor, C type
       K06563  CD209; CD209 antigen
       K10074  CLEC7A; C-type lectin domain family 7 member A
       K06558  MSR1; macrophage scavenger receptor 1
       K13884  MARCO; macrophage receptor with collagenous structure
       K08763  OLR1; oxidised low-density lipoprotein receptor 1
       K13885  SCARB1; scavenger receptor class B, member 1
       K06259  CD36; CD36 antigen
       K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
       K08008  NOX, GP91; NADPH oxidase
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
       K08010  NCF2, P67PHOX; neutrophil cytosolic factor 2
       K08012  NCF4, P40PHOX; neutrophil cytosolic factor 4
     04142 Lysosome [PATH:ko04142]
     04146 Peroxisome [PATH:ko04146]
     04140 Regulation of autophagy [PATH:ko04140]
 
   Cell motility
 
   Cell growth and death
 
   Cellular commiunity
 
 Organismal Systems
 
   Immune system
     04640 Hematopoietic cell lineage [PATH:ko04640]
     04610 Complement and coagulation cascades [PATH:ko04610]
     04611 Platelet activation [PATH:ko04611]
       K04264  TBXA2R; thromboxane A2 receptor
       K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
       K04236  F2RL3, PAR4; coagulation factor II (thrombin) receptor-like 3
       K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
       K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
       K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
       K04513  RHOA; Ras homolog gene family, member A
       K04514  ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]
       K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]
       K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
       K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
       K12757  MYL12; myosin regulatory light chain 12
       K05215  P2RX1; P2X purinoceptor 1
       K16056  ORAI1; calcium release-activated calcium channel protein 1
       K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
       K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
       K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
       K16059  STIM1; stromal interaction molecule 1
       K00907  MYLK; myosin-light-chain kinase [EC:2.7.11.18]
       K04270  P2RY1; purinergic receptor P2Y, G protein-coupled, 1
       K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
       K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
       K06069  APKC; atypical protein kinase C [EC:2.7.11.13]
       K04350  RASGRP1; RAS guanyl-releasing protein 1
       K12361  RASGRP2; RAS guanyl-releasing protein 2
       K04353  RAP1A; Ras-related protein Rap-1A
       K07836  RAP1B; Ras-related protein Rap-1B
       K17704  APBB1IP, RIAM; amyloid beta A4 precursor protein-binding family B member 1-interacting protein
       K06271  TLN; talin
       K06476  ITGA2B; integrin alpha 2B
       K06493  ITGB3; integrin beta 3
       K17084  FERMT3, KIND3; kindlin 3
       K03903  FGA; fibrinogen alpha chain
       K03904  FGB; fibrinogen beta chain
       K03905  FGG; fibrinogen gamma chain
       K04298  P2RY12; purinergic receptor P2Y, G protein-coupled, 12
       K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
       K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
       K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
       K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
       K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
       K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
       K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
       K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
       K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
       K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
       K04263  PTGIR; prostacyclin receptor
       K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04345  PKA; protein kinase A [EC:2.7.11.11]
       K06274  VASP; vasodilator-stimulated phosphoprotein
       K05692  ACTB_G1; actin beta/gamma 1
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K05732  GRLF1; glucocorticoid receptor DNA-binding factor 1
       K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc region receptor II-a
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K06236  COL1AS; collagen, type I/II/III/V/XI/XXIV/XXVII, alpha
       K06264  GP6; platelet glycoprotein VI
       K07983  FCER1G; Fc receptor, IgE, high affinity I, gamma polypeptide
       K05854  LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
       K05703  FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]
       K06481  ITGA2; integrin alpha 2
       K05719  ITGB1; integrin beta 1
       K07361  LCP2; lymphocyte cytosolic protein 2
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K07370  BTK; Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]
       K03900  VWF; von Willebrand factor
       K06260  GP5; platelet glycoprotein V
       K06261  GP1BA; platelet glycoprotein Ib alpha chain
       K06262  GP1BB; platelet glycoprotein Ib beta chain
       K06263  GP9; platelet glycoprotein IX
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K13242  NOS3; nitric-oxide synthase, endothelial [EC:1.14.13.39]
       K12318  GUCY1A; guanylate cyclase soluble subunit alpha [EC:4.6.1.2]
       K12319  GUCY1B; guanylate cyclase soluble subunit beta [EC:4.6.1.2]
       K07376  PRKG; protein kinase, cGMP-dependent [EC:2.7.11.12]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K16342  PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]
       K00509  PTGS1, COX1; prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1]
       K01832  TBXAS1, CYP5A; thromboxane-A synthase [EC:5.3.99.5]
       K08508  SNAP23; synaptosomal-associated protein 23
       K08512  VAMP8; vesicle-associated membrane protein 8
     04620 Toll-like receptor signaling pathway [PATH:ko04620]
     04621 NOD-like receptor signaling pathway [PATH:ko04621]
     04622 RIG-I-like receptor signaling pathway [PATH:ko04622]
     04623 Cytosolic DNA-sensing pathway [PATH:ko04623]
     04650 Natural killer cell mediated cytotoxicity [PATH:ko04650]
     04612 Antigen processing and presentation [PATH:ko04612]
     04660 T cell receptor signaling pathway [PATH:ko04660]
     04662 B cell receptor signaling pathway [PATH:ko04662]
     04664 Fc epsilon RI signaling pathway [PATH:ko04664]
     04666 Fc gamma R-mediated phagocytosis [PATH:ko04666]
       K06856  IGH; immunoglobulin heavy chain
       K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
       K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc region receptor II-a
       K06478  PTPRC, CD45; receptor-type tyrosine-protein phosphatase C [EC:3.1.3.48]
       K08893  HCK; hemopoietic cell kinase [EC:2.7.10.2]
       K05854  LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04688  RPS6KB; p70 ribosomal S6 kinase [EC:2.7.11.1]
       K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K06068  PRKCD; novel protein kinase C delta type [EC:2.7.11.13]
       K18050  PRKCE; novel protein kinase C epsilon type [EC:2.7.11.13]
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K12561  MARCKS; myristoylated alanine-rich C-kinase substrate
       K13536  MARCKSL1, MRP; MARCKS-related protein
       K01115  PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
       K01080  PPAP2; phosphatidate phosphatase [EC:3.1.3.4]
       K04718  SPHK; sphingosine kinase [EC:2.7.1.91]
       K02677  CPKC; classical protein kinase C [EC:2.7.11.13]
       K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
       K05768  GSN; gelsolin
       K05730  VAV; guanine nucleotide exchange factor VAV
       K04393  CDC42; cell division control protein 42
       K05747  WAS; Wiskott-Aldrich syndrome protein
       K06274  VASP; vasodilator-stimulated phosphoprotein
       K05754  ARPC5; actin related protein 2/3 complex, subunit 5
       K05755  ARPC4; actin related protein 2/3 complex, subunit 4
       K05756  ARPC3; actin related protein 2/3 complex, subunit 3
       K05757  ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
       K05758  ARPC2; actin related protein 2/3 complex, subunit 2
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
       K05753  WASF1; WAS protein family, member 1
       K05748  WASF2; WAS protein family, member 2
       K06083  WASF3; WAS protein family, member 3
       K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
       K05743  LIMK1; LIM domain kinase 1 [EC:2.7.11.1]
       K05744  LIMK2; LIM domain kinase 2 [EC:2.7.11.1]
       K05765  CFL; cofilin
       K00889  E2.7.1.68, PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
       K07941  ARF6; ADP-ribosylation factor 6
       K04438  CRK, CRKII; proto-oncogene C-crk
       K12367  DOCK2; dedicator of cytokinesis protein 2
       K12488  ASAP; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein
       K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc region receptor II-b
       K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
       K15909  SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
       K08091  GAB2; growth factor receptor bound protein 2-associated protein 2
       K07362  LAT; linker for activation of T cells
       K12562  AMPH; amphiphysin
       K12559  MYO10; myosin X
     04670 Leukocyte transendothelial migration [PATH:ko04670]
     04672 Intestinal immune network for IgA production [PATH:ko04672]
     04062 Chemokine signaling pathway [PATH:ko04062]
 
   Endocrine system
 
   Circulatory system
 
   Digestive system
 
   Excretory system
 
   Nervous system
 
   Sensory system
 
   Development
     04320 Dorso-ventral axis formation [PATH:ko04320]
     04360 Axon guidance [PATH:ko04360]
     04380 Osteoclast differentiation [PATH:ko04380]
       K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
       K05090  CSF1R, FMS; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
       K04364  GRB2; growth factor receptor-binding protein 2
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
       K02649  PIK3R; phosphoinositide-3-kinase, regulatory subunit
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K04687  IFNG; interferon gamma
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K11220  STAT1; signal transducer and activator of transcription 1
       K04383  IL1A; interleukin 1 alpha
       K04519  IL1B; interleukin 1 beta
       K04386  IL1R1; interleukin 1 receptor type I
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K03158  TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
       K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
       K05473  TNFSF11, RANKL; tumor necrosis factor ligand superfamily member 11
       K05147  TNFRSF11A, RANK; tumor necrosis factor receptor superfamily member 11A
       K05148  TNFRSF11B, OPG; tumor necrosis factor receptor superfamily member 11B
       K03173  TRAF2; TNF receptor-associated factor 2
       K03175  TRAF6; TNF receptor-associated factor 6
       K05856  LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
       K05703  FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]
       K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
       K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
       K09253  RELB; transcription factor RelB
       K04469  NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K04403  MAP3K7IP1, TAB1; TAK1-binding protein 1
       K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
       K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
       K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K04735  RELA; transcription factor p65
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K17332  NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2
       K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
       K05415  IFNB; interferon beta
       K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
       K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K04379  FOS; proto-oncogene protein c-fos
       K09029  FOSB; protein FosB
       K09030  FOSL2; fos-like antigen 2
       K04502  FOSL1; fos-like antigen 1
       K04448  JUN; transcription factor AP-1
       K04449  JUND; transcription factor jun-D
       K09028  JUNB; transcription factor jun-B
       K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
       K08008  NOX, GP91; NADPH oxidase
       K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
       K08010  NCF2, P67PHOX; neutrophil cytosolic factor 2
       K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
       K08012  NCF4, P40PHOX; neutrophil cytosolic factor 4
       K07370  BTK; Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]
       K07364  TEC; tyrosine-protein kinase Tec [EC:2.7.10.2]
       K14377  OSCAR; osteoclast-associated immunoglobulin-like receptor
       K06512  LILR; leukocyte immunoglobulin-like receptor
       K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
       K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc region receptor II-a
       K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc region receptor II-b
       K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc region receptor II-c
       K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
       K14378  TREM2; triggering receptor expressed on myeloid cells 2
       K06551  SIRPA_B1_G; signal-regulatory protein alpha/beta1/gamma
       K07992  TYROBP, DAP12; TYRO protein tyrosine kinase binding protein
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K07371  BLNK; B-cell linker protein
       K07361  LCP2; lymphocyte cytosolic protein 2
       K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K05869  CAMK4; calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K09438  SPI1; transcription factor PU.1
       K09455  MITF; microphthalmia-associated transcription factor
       K01371  CTSK; cathepsin K [EC:3.4.22.38]
       K14379  ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]
       K04576  CALCR; calcitonin receptor
       K06493  ITGB3; integrin beta 3
       K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
       K05130  IFNAR1; interferon receptor 1
       K05131  IFNAR2; interferon receptor 2
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K11219  TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
       K11221  STAT2; signal transducer and activator of transcription 2
       K04693  IRF9, ISGF3G, P48; interferon regulatory factor 9
       K04694  SOCS1, JAB; suppressor of cytokine signaling 1
       K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
       K08091  GAB2; growth factor receptor bound protein 2-associated protein 2
       K14380  FHL2; four and a half LIM domains protein 2
       K08601  CYLD, USLP2; ubiquitin thioesterase CYLD [EC:3.4.19.12]
       K14381  SQSTM1; sequestosome 1
 
   Environmental adaptation
 
 Human Diseases
 
   Cancers
 
   Immune diseases
     05310 Asthma [PATH:ko05310]
     05322 Systemic lupus erythematosus [PATH:ko05322]
       K03986  C1QA; complement C1q subcomponent subunit A
       K03987  C1QB; complement C1q subcomponent subunit B
       K03988  C1QG; complement C1q subcomponent subunit C
       K01332  C2; complement component 2 [EC:3.4.21.43]
       K03989  C4; complement component 4
       K11251  H2A; histone H2A
       K11252  H2B; histone H2B
       K11253  H3; histone H3
       K11254  H4; histone H4
       K11086  SNRPB, SMB; small nuclear ribonucleoprotein B and B'
       K11087  SNRPD1, SMD1; small nuclear ribonucleoprotein D1
       K11088  SNRPD3, SMD3; small nuclear ribonucleoprotein D3
       K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
       K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
       K10651  TRIM21, SSA1; tripartite motif-containing protein 21 [EC:6.3.2.19]
       K11089  TROVE2, SSA2; 60 kDa SS-A/Ro ribonucleoprotein
       K11090  LA, SSB; lupus La protein
       K05699  ACTN; actinin alpha
       K06752  MHC2; major histocompatibility complex, class II
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K05412  CD80; CD80 antigen
       K05413  CD86; CD86 antigen
       K06470  CD28; CD28 antigen
       K03161  TNFSF5, CD40L; tumor necrosis factor ligand superfamily member 5
       K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K04687  IFNG; interferon gamma
       K05443  IL10, CSIF; interleukin 10
       K06856  IGH; immunoglobulin heavy chain
       K01330  C1R; complement component 1, r subcomponent [EC:3.4.21.41]
       K01331  C1S; complement component 1, s subcomponent [EC:3.4.21.42]
       K03990  C3; complement component 3
       K03994  C5; complement component 5
       K03995  C6; complement component 6
       K03996  C7; complement component 7
       K03997  C8A; complement component 8 subunit alpha
       K03998  C8B; complement component 8 subunit beta
       K03999  C8G; complement component 8 subunit gamma
       K04000  C9; complement component 9
       K01319  CTSG; cathepsin G [EC:3.4.21.20]
       K01327  ELANE; leukocyte elastase [EC:3.4.21.37]
       K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
       K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc region receptor II-a
       K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
     05323 Rheumatoid arthritis [PATH:ko05323]
     05320 Autoimmune thyroid disease [PATH:ko05320]
     05321 Inflammatiory bowel disease (IBD) [PATH:ko05321]
     05330 Allograft rejection [PATH:ko05330]
     05332 Graft-versus-host disease [PATH:ko05332]
     05340 Primary immunodeficiency [PATH:ko05340]
 
   Neurodegenerative diseases
 
   Substance dependence
 
   Cardiovascular diseases
 
   Endocrine and metabolic diseases
 
   Infectious diseases
     05110 Vibrio cholerae infection [PATH:ko05110]
     05111 Vibrio cholerae pathogenic cycle [PATH:ko05111]
     05120 Epithelial cell signaling in Helicobacter pylori infection [PATH:ko05120]
     05130 Pathogenic Escherichia coli infection [PATH:ko05130]
     05132 Salmonella infection [PATH:ko05132]
     05131 Shigellosis [PATH:ko05131]
     05133 Pertussis [PATH:ko05133]
     05134 Legionellosis [PATH:ko05134]
     05150 Staphylococcus aureus infection [PATH:ko05150]
       K14192  clfB; clumping factor B
       K03905  FGG; fibrinogen gamma chain
       K14193  isdA; iron-regulated surface determinant protein A
       K14194  sdrC_D_E; serine-aspartate repeat-containing protein C/D/E
       K14195  sasG; surface protein G
       K03990  C3; complement component 3
       K01335  CFB; component factor B [EC:3.4.21.47]
       K01334  CFD; component factor D [EC:3.4.21.46]
       K04004  HF1; complement factor H
       K03991  MBL; mannose-binding lectin
       K03992  MASP1; mannan-binding lectin serine protease 1 [EC:3.4.21.-]
       K03993  MASP2; mannan-binding lectin serine protease 2 [EC:3.4.21.104]
       K06856  IGH; immunoglobulin heavy chain
       K03986  C1QA; complement C1q subcomponent subunit A
       K03987  C1QB; complement C1q subcomponent subunit B
       K03988  C1QG; complement C1q subcomponent subunit C
       K01330  C1R; complement component 1, r subcomponent [EC:3.4.21.41]
       K01331  C1S; complement component 1, s subcomponent [EC:3.4.21.42]
       K01332  C2; complement component 2 [EC:3.4.21.43]
       K03989  C4; complement component 4
       K03994  C5; complement component 5
       K04009  C3AR1; C3a anaphylatoxin chemotactic receptor
       K04010  C5AR1; C5a anaphylatoxin chemotactic receptor
       K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
       K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc region receptor II-a
       K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc region receptor II-b
       K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc region receptor II-c
       K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
       K06513  FCAR, CD89; CD89 antigen
       K04173  FPRL; formyl peptide receptor-like
       K04172  FPR1; formyl peptide receptor 1
       K01315  PLG; plasminogen [EC:3.4.21.7]
       K01333  CFI; complement factor I [EC:3.4.21.45]
       K14196  spa; immunoglobulin G-binding protein A
       K14197  sbi; immunoglobulin G-binding protein Sbi
       K14198  sak; staphylokinase
       K14199  scn, scin; staphylococcal complement inhibitor
       K14200  fib, efb; fibrinogen-binding protein
       K14201  clfA; clumping factor A
       K14202  chp, chips; chemotaxis inhibitory protein
       K14203  flr, flipr; FPRL1 inhibitory protein
       K06544  SELPLG; selectin P ligand
       K06496  SELP; selectin, platele
       K14204  eap, map; protein Map
       K06490  ICAM1; intercellular adhesion molecule 1
       K05718  ITGAL; integrin alpha L
       K06461  ITGAM; integrin alpha M
       K06464  ITGB2; integrin beta 2
       K11631  bceA; bacitracin transport system ATP-binding protein
       K11632  bceB; bacitracin transport system permease protein
       K03367  dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]
       K03739  dltB; membrane protein involved in D-alanine export
       K14188  dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]
       K03740  dltD; D-alanine transfer protein
       K14205  mprF, fmtC; phosphatidylglycerol lysyltransferase [EC:2.3.2.3]
       K01401  aur; aureolysin [EC:3.4.24.29]
       K11038  hlg, luk; leukocidin/hemolysin toxin family protein
       K11040  se; staphylococcal enterotoxin
       K11043  tst; toxic shock syndrome toxin-1
       K11041  eta; exfoliative toxin A/B
       K07596  DSG1; desmoglein 1
       K10784  TRAV; T cell receptor alpha chain V region
       K10785  TRBV; T-cell receptor beta chain V region
       K06752  MHC2; major histocompatibility complex, class II
       K04279  PTAFR; platelet-activating factor receptor
       K05443  IL10, CSIF; interleukin 10
     05152 Tuberculosis [PATH:ko05152]
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K03158  TNFRSF1A, TNFR1; tumor necrosis factor receptor superfamily member 1A
       K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
       K02373  FADD; FAS-associated death domain protein
       K04398  CASP8; caspase 8 [EC:3.4.22.61]
       K04400  CASP10; caspase 10 [EC:3.4.22.63]
       K02187  CASP3; caspase 3 [EC:3.4.22.56]
       K04726  BID; BH3 interacting domain death agonist
       K02159  BAX; apoptosis regulator BAX
       K08738  CYC; cytochrome c
       K04399  CASP9; caspase 9 [EC:3.4.22.62]
       K02084  APAF1; apoptotic protease-activating factor
       K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
       K02158  BAD; BCL2-antagonist of cell death
       K02161  BCL2; apoptosis regulator BCL-2
       K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
       K04687  IFNG; interferon gamma
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
       K11220  STAT1; signal transducer and activator of transcription 1
       K08060  CIITA; class II, major histocompatibility complex, transactivator
       K08061  RFX5; regulatory factor X 5
       K08062  RFXANK; regulatory factor X-associated ankyrin-containing protein
       K08063  RFXAP; regulatory factor X-associated protein
       K08064  NFYA; nuclear transcription factor Y, alpha
       K08065  NFYB; nuclear transcription Y subunit beta
       K08066  NFYC; nuclear transcription factor Y, gamma
       K05870  CREB1; cyclic AMP-responsive element-binding protein 1
       K06752  MHC2; major histocompatibility complex, class II
       K06505  CD74, DHLAG; CD74 antigen
       K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
       K05443  IL10, CSIF; interleukin 10
       K05134  IL10RA; interleukin 10 receptor alpha
       K05135  IL10RB; interleukin 10 receptor beta
       K01368  CTSS; cathepsin S [EC:3.4.22.27]
       K10059  CLEC4E; C-type lectin domain family 4 member E
       K07983  FCER1G; Fc receptor, IgE, high affinity I, gamma polypeptide
       K10074  CLEC7A; C-type lectin domain family 7 member A
       K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
       K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
       K12794  CARD9; caspase recruitment domain-containing protein 9
       K07369  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
       K07368  BCL10; B-cell CLL/lymphoma 10
       K14952  namH; UDP-MurNAc hydroxylase
       K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
       K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]
       K14953  lpqH; ipoprotein LpqH
       K14954  lprG; lipoprotein LprG
       K14955  lprA; lipoprotein LprA
       K02040  pstS; phosphate transport system substrate-binding protein
       K04043  dnaK; molecular chaperone DnaK
       K04077  groEL, HSPD1; chaperonin GroEL
       K14956  esxA, esat6; 6 kDa early secretory antigenic target
       K05399  LBP; lipopolysaccharide-binding protein
       K10159  TLR2; toll-like receptor 2
       K05398  TLR1; toll-like receptor 1
       K10169  TLR6; toll-like receptor 6
       K10160  TLR4; toll-like receptor 4
       K04391  CD14; CD14 antigen
       K05403  TIRAP; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K04730  IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
       K04731  IRAK2; interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1]
       K03175  TRAF6; TNF receptor-associated factor 6
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04440  JNK; c-Jun N-terminal kinase [EC:2.7.11.24]
       K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
       K05405  IL6; interleukin 6
       K05406  IL12A; interleukin 12A
       K05425  IL12B; interleukin 12B
       K05482  IL18, IL1F4; interleukin 18
       K05426  IL23A; interleukin 23, alpha subunit p19
       K04383  IL1A; interleukin 1 alpha
       K04519  IL1B; interleukin 1 beta
       K10048  CEBPB; CCAAT/enhancer binding protein (C/EBP), beta
       K10049  CEBPG; CCAAT/enhancer binding protein (C/EBP), gamma
       K10161  TLR9; toll-like receptor 9
       K05414  IFNA; interferon alpha
       K05415  IFNB; interferon beta
       K06563  CD209; CD209 antigen
       K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
       K04513  RHOA; Ras homolog gene family, member A
       K14957  LSP1; lymphocyte-specific protein 1
       K08862  PLK3, CNK; polo-like kinase 3 [EC:2.7.11.21]
       K14958  KSR1; kinase suppressor of Ras 1
       K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K07438  CYP27B; 25-hydroxyvitamin D3 1alpha-hydroxylase [EC:1.14.13.13]
       K08539  NR1I1, VDR; vitamin D3 receptor
       K13916  CAMP, LL37; cathelicidin antimicrobial peptide
       K03990  C3; complement component 3
       K04011  CR1, CD35; complement component (3b/4b) receptor 1
       K06462  ITGAX; integrin alpha X
       K06464  ITGB2; integrin beta 2
       K06461  ITGAM; integrin alpha M
       K06560  MRC; mannose receptor, C type
       K04718  SPHK; sphingosine kinase [EC:2.7.1.91]
       K02183  CALM; calmodulin
       K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
       K07887  RAB5A; Ras-related protein Rab-5A
       K07888  RAB5B; Ras-related protein Rab-5B
       K07889  RAB5C; Ras-related protein Rab-5C
       K12478  EEA1; early endosome antigen 1
       K07897  RAB7A; Ras-related protein Rab-7A
       K01379  CTSD; cathepsin D [EC:3.4.23.5]
       K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
       K02146  ATPeV0D, ATP6D; V-type H+-transporting ATPase subunit d
       K02144  ATPeV1H; V-type H+-transporting ATPase subunit H
       K03662  ATPeVS1, ATP6S1; V-type H+-transporting ATPase S1 subunit
       K02155  ATPeV0C, ATP6L; V-type H+-transporting ATPase 16kDa proteolipid subunit
       K03661  ATPeV0B, ATP6F; V-type H+-transporting ATPase 21kDa proteolipid subunit
       K06528  LAMP1_2, CD107; lysosomal-associated membrane protein 1/2
       K01078  E3.1.3.2; acid phosphatase [EC:3.1.3.2]
       K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
       K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
       K13882  CORO1A; coronin-1A
       K14949  pknG; serine/threonine-protein kinase PknG [EC:2.7.11.1]
       K06856  IGH; immunoglobulin heavy chain
       K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
       K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc region receptor II-a
       K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc region receptor II-b
       K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc region receptor II-c
       K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
     05100 Bacterial invasion of epithelial cells [PATH:ko05100]
     05166 HTLV-I infection [PATH:ko05166]
     05162 Measles [PATH:ko05162]
     05164 Influenza A [PATH:ko05164]
     05161 Hepatitis B [PATH:ko05161]
     05160 Hepatitis C [PATH:ko05160]
     05168 Herpes simplex infection [PATH:ko05168]
     05169 Epstein-Barr virus infection [PATH:ko05169]
     05146 Amoebiasis [PATH:ko05146]
     05144 Malaria [PATH:ko05144]
     05145 Toxoplasmosis [PATH:ko05145]
     05140 Leishmaniasis [PATH:ko05140]
       K10159  TLR2; toll-like receptor 2
       K10160  TLR4; toll-like receptor 4
       K04729  MYD88; myeloid differentiation primary response protein MyD88
       K04730  IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
       K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
       K03175  TRAF6; TNF receptor-associated factor 6
       K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
       K04403  MAP3K7IP1, TAB1; TAK1-binding protein 1
       K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
       K02581  NFKBIB; NF-kappa-B inhibitor beta
       K04734  NFKBIA; NF-kappa-B inhibitor alpha
       K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
       K04735  RELA; transcription factor p65
       K04383  IL1A; interleukin 1 alpha
       K04519  IL1B; interleukin 1 beta
       K05406  IL12A; interleukin 12A
       K05425  IL12B; interleukin 12B
       K03156  TNFA; tumor necrosis factor superfamily, member 2
       K05430  IL4; interleukin 4
       K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
       K05443  IL10, CSIF; interleukin 10
       K13375  TGFB1; transforming growth factor beta-1
       K13376  TGFB2; transforming growth factor beta-2
       K13377  TGFB3; transforming growth factor beta-3
       K03990  C3; complement component 3
       K04011  CR1, CD35; complement component (3b/4b) receptor 1
       K06461  ITGAM; integrin alpha M
       K06464  ITGB2; integrin beta 2
       K06856  IGH; immunoglobulin heavy chain
       K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
       K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc region receptor II-a
       K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc region receptor II-c
       K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
       K01404  GP63; leishmanolysin [EC:3.4.24.36]
       K06483  ITGA4; integrin alpha 4
       K05719  ITGB1; integrin beta 1
       K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
       K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
       K08010  NCF2, P67PHOX; neutrophil cytosolic factor 2
       K08012  NCF4, P40PHOX; neutrophil cytosolic factor 4
       K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
       K04371  MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
       K04375  ELK1; ETS domain-containing protein Elk-1
       K04379  FOS; proto-oncogene protein c-fos
       K04448  JUN; transcription factor AP-1
       K04441  P38; p38 MAP kinase [EC:2.7.11.24]
       K04687  IFNG; interferon gamma
       K05132  IFNGR1, CD119; interferon gamma receptor 1
       K05133  IFNGR2; interferon gamma receptor 2
       K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
       K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
       K11220  STAT1; signal transducer and activator of transcription 1
       K06752  MHC2; major histocompatibility complex, class II
       K13536  MARCKSL1, MRP; MARCKS-related protein
       K13537  CPB; cysteine peptidase B [EC:3.4.22.-]
       K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]
     05142 Chagas disease (American trypanosomiasis) [PATH:ko05142]
     05143 African trypanosomiasis [PATH:ko05143]
 
   Drug resistance

[ BRITE | KEGG2 | KEGG ]
Last updated: November 27, 2014